Skip Navigation
Skip to contents

JMD : Journal of Movement Disorders

OPEN ACCESS
SEARCH
Search

Accepted articles

Page Path
HOME > Browse Articles > Accepted articles
9 Accepted articles
Filter
Filter
Article category
Keywords
Authors
Original Articles
Retinal Thinning as a Marker of Disease Severity in Progressive Supranuclear Palsy
Yueting Chen, Haotian Wang, Bo Wang, Wenbo Li, Panpan Ye, Wen Xu, Peng Liu, Xinhui Chen, Zhidong Cen, Zhiyuan Ouyang, Sheng Wu, Xiaofeng Dou, Yi Liao, Hong Zhang, Mei Tian, Wei Luo
Received May 21, 2023  Accepted September 25, 2023  Published online September 26, 2023  
DOI: https://doi.org/10.14802/jmd.23102    [Accepted]
  • 103 View
  • 6 Download
AbstractAbstract PDF
Objective
Progressive supranuclear palsy (PSP) involves a variety of visual symptoms that are thought to be partly caused by structural abnormalities of the retina. However, the relationship between retinal structural changes, disease severity, and intracranial alterations remains unknown. We investigated distinct retinal thinning patterns and their relationship with clinical severity and intracranial alteration in a PSP cohort.
Methods
We enrolled 19 patients with PSP (38 eyes) and 20 age-matched healthy controls (40 eyes). All participants underwent peripapillary and macular optical coherence tomography. Brain 11C-2β-carbomethoxy-3β-(4-fluorophenyl) tropane (11C-CFT) and 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography imaging were also performed in patients with PSP. We investigated the association between retinal thickness changes and clinical features, striatal dopamine transporter availability, and cerebral glucose metabolism.
Results
The peripapillary retinal nerve fiber layer (pRNFL) and macula were significantly thinner in patients with PSP than in controls. The thickness of the superior sector of the pRNFL showed a significant negative relationship with the Movement Disorder Society-Unified Parkinson's Disease Rating Scale part III and Hoehn and Yahr staging scale scores. A significant negative correlation was found between outer inferior macular thickness and disease duration. Outer temporal macular thickness was positively correlated with Montreal Cognitive Assessment scores. In PSP, lower outer temporal macular thickness was also positively correlated with decreased dopamine transporter binding in the caudate.
Conclusions
The pRNFL and macular thinning may be candidate markers for monitoring disease severity. Additionally, macular thinning may be an in vivo indicator of nigrostriatal dopaminergic cell degeneration in PSP patients.
Emotion Recognition in Multiple System Atrophy – An exploratory Eye-Tracking Study
Victoria Sidoroff, Federico Carbone, Philipp Ellmerer, Stefanie Bair, Alexandra Hoffmann, Thomas Maran, Florian Krismer, Philipp Mahlknecht, Katherina Mair, Cecilia Raccagni, Jean-Pierre Ndayisaba, Klaus Seppi, Gregor K. Wenning, Atbin Djamshidian
Received May 1, 2023  Accepted September 24, 2023  Published online September 26, 2023  
DOI: https://doi.org/10.14802/jmd.23090    [Accepted]
  • 97 View
  • 9 Download
AbstractAbstract PDF
Objectives
Emotional processing is a core feature of social interactions and has been well studied in patients with idiopathic Parkinson’s disease (PD) with contradictory results. However, these studies excluded patients with atypical parkinsonism such as multiple system atrophy (MSA). The objective of this exploratory study was to get better insights into emotion processing in patients with MSA using an Eye-Tracker.
Methods
We included 21 MSA patients, 15 PD patients and 19 matched controls into this study. A dynamic and a static emotion recognition task was performed and fixations were analysed for different areas of interest. Participants underwent neuropsychological testing, and assessment of depression and alexithymia.
Results
MSA patients recognized anger less accurately than controls (p=0.02) and had overall less fixations compared to controls (p=0.001). In the static task, MSA had less fixations (p<0.001) and a longer time to first fixation (p=0.026) on the eye region. Furthermore, MSA had an overall longer fixation duration compared to PD (p=0.004) and longer fixation on the nose compared to controls (p=0.005). Alexithymia-scores were higher in MSA versus controls (p=0.038).
Conclusion
This study demonstrated an impaired recognition of anger in MSA compared to HCs. Fewer and later fixations to the eyes together with a centre bias suggest clinically avoidance of eye contact, which may be a characteristic gaze behaviour for MSA.
Hair loss, old and uninterested nonmotor symptom in Parkinson’s disease during dopaminergic therapy
Jungyeun Lee, Hwa Jung Ryu, Soon Young Hwang, Seong-Beom Koh
Received May 1, 2023  Accepted September 24, 2023  Published online September 26, 2023  
DOI: https://doi.org/10.14802/jmd.23088    [Accepted]
  • 87 View
  • 5 Download
AbstractAbstract PDF
Background
Hair loss has been reported to occur during dopaminergic therapy in Parkinson’s disease. The mechanism by which dopaminergic therapy induces hair loss is not well understood. Dopamine receptors are present in the hair follicle where they regulate melanin production. However, the role of dopamine receptors in hair growth is still not well understood. Objective: This study aimed to evaluate the prevalence of hair loss and identify factors associated with complaint of hair loss in Parkinson’s disease.
Methods
A cross-sectional design was applied, involving 495 Parkinson’s disease patients to evaluate hair loss status. Patients completed a questionnaire and scalp/hair examinations were performed. Patients with underlying conditions that could affect hair loss and those prescribed medications known to increase the risk of hair loss were excluded. Finally, 291 patients (58.8%) were included for analysis.
Results
Among the total of 495 patients, 138 (27.9%) reported hair loss. Interestingly, more than half of the patients who complained of hair loss (79 out of 138) did not utilize treatments such as hair products, massage, diet modifications, or alopecia medication. Hair inspection by a single investigator revealed objective hair loss in 263 patients (53.1%). Analysis of factors associated with hair loss complaints showed that the intake of dopaminergic medication with a levodopa-equivalent daily dose >448 mg was associated with complaint of hair loss.
Conclusions
Dopaminergic medication is associated hair loss complaints in Parkinson’s disease patients.
Caregiver burden of patients with Huntington’s disease in South Korea
Chan Young Lee, Chaewon Shin, Yun Su Hwang, Eungseok Oh, Manho Kim, Hyun Sook Kim, Sun Ju Chung, Young Hee Sung, Won Tae Yoon, Jin Whan Cho, Jae-Hyeok Lee, Han-Joon Kim, Hee Jin Chang, Beomseok Jeon, Kyung Ah Woo, Seong-Beom Koh, Kyum-Yil Kwon, Jangsup Moon, Young Eun Kim, Jee-Young Lee
Received July 19, 2023  Accepted September 8, 2023  Published online September 11, 2023  
DOI: https://doi.org/10.14802/jmd.23134    [Accepted]
  • 207 View
  • 20 Download
AbstractAbstract PDF
Purpose
This is the first prospective cohort study of Huntington’s disease (HD) in Korea. This study aimed to investigate caregiver burden in relation to the characteristics of patients and caregivers.
Methods
From August 2020 to February 2022, we enrolled patients with HD from 13 university hospitals in Korea. We collected the 12-item Zarit Burden Interview (ZBI-12) to evaluate the caregiver burden. We evaluated the clinical associates of the ZBI-12 scores by the linear regression analysis and investigated the difference between the low and high burden groups.
Results
Sixty-five patients with HD and 45 caregivers have been enrolled in this cohort study so far. The average onset of motor symptoms was 49.3±12.3 years with the average (CAG)n of 42.9±4.0 (38-65). The ZBI-12 score in our caregivers were 17.6±14.2. The higher caregiver burden was associated with the more severe Shoulson and Fahn stages (p-value=0.038) of the patients. The higher ZBI-12 score was also associated with the lower independence scale (B=-0.154, p-value=0.006) and the functional capacity (B=-1.082, p-value=0.002) of patients. The caregiving duration was longer in the high than the low burden groups. Caregivers’ demographic, blood-relation, and marital and social status did not affect the burden significantly.
Conclusion
HD patient’s neurological status exerts huge impact on the caregiver burden regardless of the demographic or social status of the caregiver. This study emphasizes the need of establishing optimal support system to HD family in Korea. A future longitudinal analysis could help us understand how disease progression aggravate the caregiver burden throughout the entire disease course.
Letters to the editor
Factors associated with anticholinergic-induced oral-buccal-lingual dyskinesia in Parkinson’s disease
Joonyoung Ha, Suk Yun Kang, Kyoungwon Baik, Young H. Sohn, Phil Hyu Lee, Min Seok Baek, Jin Yong Hong
Received April 8, 2023  Accepted September 22, 2023  Published online September 22, 2023  
DOI: https://doi.org/10.14802/jmd.23069    [Accepted]
  • 95 View
  • 14 Download
PDF
Jaw Opening Myoclonus in Subacute Sclerosing Panencephalitis: A new phenotypic observation
Divyani Garg, Vanshika Kakkar, Suvasini Sharma
Received August 7, 2023  Accepted September 14, 2023  Published online September 14, 2023  
DOI: https://doi.org/10.14802/jmd.23158    [Accepted]
  • 379 View
  • 56 Download
PDF
A novel pathogenic PSEN1 variant in a patient with dystonia-parkinsonism without dementia
Maria Chiara Malaguti, Alessio di Fonzo, Chiara Longo, Raffaella Di Giacopo, Costanza Papagno, Davide Donner, Umberto Rozzanigo, Edoardo Monfrini
Received June 30, 2023  Accepted September 13, 2023  Published online September 14, 2023  
DOI: https://doi.org/10.14802/jmd.23125    [Accepted]
  • 182 View
  • 16 Download
PDF
“Face of the giant panda” sign and bilateral thalamic hyperintensity in isoniazid-included ataxia
Vikram V Holla, Manjunath Netravathi, Nitish Kamble, Jitender Saini, Pramod Kumar Pal
Received June 4, 2023  Accepted August 2, 2023  Published online August 2, 2023  
DOI: https://doi.org/10.14802/jmd.23112    [Accepted]
  • 187 View
  • 27 Download
PDF
Brief communication
A survey on the patients’ perspective on the telemedicine for patients with Parkinson’s disease
Jae Young Joo, Ji Young Yun, Young Eun Kim, Yu Jin Jung, Ryul Kim, Hui-Jun Yang, Woong-Woo Lee, Aryun Kim, Han Joon Kim
Received July 12, 2023  Accepted August 21, 2023  Published online August 22, 2023  
DOI: https://doi.org/10.14802/jmd.23130    [Accepted]
  • 255 View
  • 27 Download
AbstractAbstract PDF
Objective
PD patients often find it difficult to visit hospitals because of the motor symptoms, distance to the hospital, or absence of caregivers. Telemedicine is one way to solve this problem.
Methods
We surveyed 554 PD patients from eight university hospitals in Korea. The questionnaire consisted of clinical characteristics of participants, possible teleconferencing methods, and preference of telemedicine.
Results
A total of 385 patients (70%) had interest to receive telemedicine. Among them, 174 preferred telemedicine whereas 211 preferred in-person visit. The longer the duration of disease, and the longer the time required to visit the hospital, the more the patients have interest to receive telemedicine.
Conclusion
This is the first study on PD patients' preference for telemedicine in Korea. Although the majority of patients with PD have a positive perspective on telemedicine, their interest to receive telemedicine depends on their different circumstance.

JMD : Journal of Movement Disorders