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Case Report
- Suppression of Myoclonus in Corticobasal Degeneration by Levetiracetam
- Jae Wook Cho, Jae Hyeok Lee
- J Mov Disord. 2014;7(1):28-30. Published online April 30, 2014
- DOI: https://doi.org/10.14802/jmd.14007
- 10,588 View
- 103 Download
- 12 Web of Science
- 11 Crossref
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Abstract
PDF - Myoclonus in corticobasal degeneration (CBD) has often been associated with severe and difficult to treat disabilities. Levetiracetam is a new antiepileptic agent with antimyoclonic effects. Herein, we present a 72-year-old woman with clinically probable CBD and with spontaneous rhythmic myoclonus in the right foot, which was markedly ameliorated through treatment with levetiracetam. The effect of levetiracetam was associated with the decreased amplitude of enlarged cortical somatosensory evoked potentials. This result suggests that the antimyoclonic effect of levetiracetam might be mediated through the suppression of increased cortical excitability.
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Citations
Citations to this article as recorded by
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Ruth Lamb, Jonathan D. Rohrer, Andrew J. Lees, Huw R. Morris
Current Treatment Options in Neurology.2016;[Epub] CrossRef - An Update and Review of the Treatment of Myoclonus
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Current Neurology and Neuroscience Reports.2015;[Epub] CrossRef
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