Jinse Park, Jin Whan Cho, Jinyoung Youn, Engseok Oh, Wooyoung Jang, Joong-Seok Kim, Yoon-Sang Oh, Hyungyoung Hwang, Chang-Hwan Ryu, Jin-Young Ahn, Jee-Young Lee, Seong-Beom Koh, Jae H. Park, Hee-Tae Kim
J Mov Disord. 2023;16(1):86-90. Published online December 20, 2022
Objective The International Cooperative Ataxia Rating Scale (ICARS) is a semiquantitative clinical scale for ataxia that is widely used in numerous countries. The purpose of this study was to investigate the validity and reliability of the Korean-translated version of the ICARS.
Methods Eighty-eight patients who presented with cerebellar ataxia were enrolled. We investigated the construct validity using exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). We also investigated the internal consistency using Cronbach’s α and intrarater and interrater reliability using intraclass correlation coefficients.
Results The Korean-translated ICARS showed satisfactory construct validity using EFA and CFA. It also revealed good interrater and intrarater reliability and showed acceptable internal consistency. However, subscale 4 for assessing oculomotor disorder showed moderate internal consistency.
Conclusion This is the first report to investigate the validity and reliability of the Korean-translated ICARS. Our results showed excellent construct and convergent validity. The reliability is also acceptable.
Objective
To evaluate the accuracy and quality of Korean videos associated with restless legs syndrome (RLS) on YouTube.
Methods
A YouTube search was performed on April 1, 2020 using the term “restless legs syndrome” in the Korean language. Two reviewers coded the source, content, and demographics of the included videos. Video quality was assessed using the modified DISCERN (mDISCERN) instrument.
Results
Among the 80 videos analyzed, 44 (55.0%) were reliable, and 36 (45.0%) were misleading. There was a trend toward a higher number of mean daily views in the misleading videos than in the reliable videos. Most of the misleading videos (72.2%) advocated complementary and alternative medicine as a primary treatment for RLS. Although the reliable videos had higher mDISCERN scores than the misleading videos, the overall quality of the reliable videos was low.
Conclusion
Many Korean videos regarding RLS on YouTube involve a risk of exposure to misinformation and are of unsatisfactory quality.
Citations
Citations to this article as recorded by
Quality and reliability of YouTube videos as a source of information on pulmonary rehabilitation Aytül COŞAR ERTEM, Uğur ERTEM The European Research Journal.2023; 9(5): 992. CrossRef
The portrayal of hearing loss information in online Mandarin videos Chandan H. Suresh, Kiara Leng, Nilesh J. Washnik, Satyabrata Parida Journal of Otology.2023; 18(3): 152. CrossRef
YouTube as an information source for pulmonary rehabilitation in patients with COVID-19: A Cross-Sectional Study Çağlar KARABAŞ, Yıldız Gonca DOĞRU Genel Tıp Dergisi.2022; 32(3): 259. CrossRef
F-box only protein 7 (FBXO7) is a rare monogenic cause of hereditary Parkinson’s disease (PD) with an autosomal recessive mode of inheritance and a broad spectrum of clinical manifestations. Here, we report a de novo PD patient with onset at the age of 28 with novel compound heterozygous variants in the FBXO7 gene (c.1162C>T, p.Gln388X; c.80G>A, p.Arg27His). The clinical features of the patient were problematic impulse control disorder behaviors and pyromania, and pyramidal signs were negative. We describe the novel pathogenic variants of the FBXO7 gene with detailed clinical pictures to report the expanding genotypes and phenotypes of FBXO7-associated parkinsonism.
Citations
Citations to this article as recorded by
Global prevalence and incidence of Young Onset Parkinson’s disease: A systematic review and meta-analysis Fardin Nabizadeh, Homa Seyedmirzaei, Nazanin Rafiei, Seyedeh Maryam Vafaei, Dorsa Shekouh, Ehsan Mehrtabar, Ehsan Mirzaaghazadeh, Zahra Mirzaasgari Journal of Clinical Neuroscience.2024; 125: 59. CrossRef
Study of an FBXO7 patient mutation reveals Fbxo7 and PI31 co‐regulate proteasomes and mitochondria Sara Al Rawi, Lorna Simpson, Guðrún Agnarsdóttir, Neil Q. McDonald, Veronika Chernuha, Orly Elpeleg, Massimo Zeviani, Roger A. Barker, Ronen Spiegel, Heike Laman The FEBS Journal.2024; 291(12): 2565. CrossRef
Loss of the parkinsonism‐associated protein FBXO7 in glutamatergic forebrain neurons in mice leads to abnormal motor behavior and synaptic defects Jingbo Wang, Sabitha Joseph, Siv Vingill, Ekrem Dere, Lars Tatenhorst, Anja Ronnenberg, Paul Lingor, Christian Preisinger, Hannelore Ehrenreich, Jörg B. Schulz, Judith Stegmüller Journal of Neurochemistry.2023; 167(2): 296. CrossRef
Nearly Abolished Dopamine Transporter Uptake in a Patient With a Novel FBXO7 Mutation Eun Young Kim, Seon Young Kim, Youngduk Seo, Chaewon Shin Journal of Movement Disorders.2022; 15(3): 269. CrossRef
Objective
Many people dealing with Parkinson’s disease (PD) turn to complementary and alternative medicine when searching for a cure or relief from symptoms. Acupuncture is widely used in the Korean PD population to alleviate symptoms and in hopes of curing the illness. However, acupuncture use for PD patients has only recently begun to be studied scientifically and is still considered an unproven treatment for PD. Therefore, there is an urgent need for acupuncture to be studied, validated and used for PD. Thus, our study’s aim is to examine how many acupuncture studies in PD are registered and reported in Korea.
Methods
The registries Clinicaltrials.gov and the Clinical Research Information Service (CRIS) and the search engine PubMed were searched to find relevant human clinical studies involving acupuncture therapy in PD patients. We examined the registration of trials, the posting and publication of results, and whether published articles were registered.
Results
In Clinicaltrials.gov, one completed trial was found with published results. In CRIS, one completed trial was found with published results. A total of 6 publications were found in our study: 2 articles were registered, but only 1 had the registered trial number listed in the article.
Conclusion
Acupuncture is popular among the PD population in Korea regardless of its unproven safety and efficacy. Despite the pressing need for clinical trials, the number of studies listed in the registries was small, and only a few publications were registered. More effort and rigor are needed to validate the efficacy and safety of acupuncture for PD.
Ji-Young Kim, In-Uk Song, Seong-Beom Koh, Tae-Beom Ahn, Sang Jin Kim, Sang-Myung Cheon, Jin Whan Cho, Yun Joong Kim, Hyeo-Il Ma, Mee-Young Park, Jong Sam Baik, Phil Hyu Lee, Sun Ju Chung, Jong-Min Kim, Han-Joon Kim, Young-Hee Sung, Do Young Kwon, Jae-Hyeok Lee, Jee-Young Lee, Ji Sun Kim, Ji Young Yun, Hee Jin Kim, Jin Young Hong, Mi-Jung Kim, Jinyoung Youn, Ji Seon Kim, Eung Seok Oh, Hui-Jun Yang, Won Tae Yoon, Sooyeoun You, Kyum-Yil Kwon, Hyung-Eun Park, Su-Yun Lee, Younsoo Kim, Hee-Tae Kim, Joong-Seok Kim
J Mov Disord. 2017;10(1):29-34. Published online January 18, 2017
Objective
Autonomic symptoms are commonly observed in patients with Parkinson’s disease (PD) and often limit the activities of daily living. The Scale for Outcomes in Parkinson’s disease-Autonomic (SCOPA-AUT) was developed to evaluate and quantify autonomic symptoms in PD. The goal of this study was to translate the original SCOPA-AUT, which was written in English, into Korean and to evaluate its reliability and validity for Korean PD patients.
Methods
For the translation, the following processes were performed: forward translation, backward translation, expert review, pretest of the pre-final version and development of the final Korean version of SCOPA-AUT (K-SCOPA-AUT). In total, 127 patients with PD from 31 movement disorder clinics of university-affiliated hospitals in Korea were enrolled in this study. All patients were assessed using the K-SCOPA-AUT and other motor, non-motor, and quality of life scores. Test-retest reliability for the K-SCOPA-AUT was assessed over a time interval of 10−14 days.
Results
The internal consistency and reliability of the K-SCOPA-AUT was 0.727 as measured by the mean Cronbach’s α-coefficient. The test-retest correlation reliability was 0.859 by the Guttman split-half coefficient. The total K-SCOPA-AUT score showed a positive correlation with other non-motor symptoms [the Korean version of non-motor symptom scale (K-NMSS)], activities of daily living (Unified Parkinson’s Disease Rating Scale part II) and quality of life [the Korean version of Parkinson’s Disease Quality of Life 39 (K-PDQ39)].
Conclusion
The K-SCOPA-AUT had good reliability and validity for the assessment of autonomic dysfunction in Korean PD patients. Autonomic symptom severities were associated with many other motor and non-motor impairments and influenced quality of life.
Citations
Citations to this article as recorded by
Baseline prevalence and longitudinal assessment of autonomic dysfunction in early Parkinson’s disease Lanqing Yang, Huan Gao, Min Ye Journal of Neural Transmission.2024; 131(2): 127. CrossRef
Association Between Gait and Dysautonomia in Patients With De Novo Parkinson’s Disease: Forward Gait Versus Backward Gait Seon-Min Lee, Mina Lee, Eun Ji Lee, Rae On Kim, Yongduk Kim, Kyum-Yil Kwon Journal of Movement Disorders.2023; 16(1): 59. CrossRef
Beyond shallow feelings of complex affect: Non-motor correlates of subjective emotional experience in Parkinson’s disease Claudia Carricarte Naranjo, Claudia Sánchez Luaces, Ivonne Pedroso Ibáñez, Andrés Machado, Hichem Sahli, María Antonieta Bobes, Vincenzo De Luca PLOS ONE.2023; 18(2): e0281959. CrossRef
Autonomic function and motor subtypes in Parkinson’s disease: a multicentre cross-sectional study Si-Chun Gu, Rong Shi, Chen Gao, Xiao-Lei Yuan, You Wu, Zhen-Guo Liu, Chang-De Wang, Shao-Rong Zhao, Xiqun Chen, Can-Xing Yuan, Qing Ye Scientific Reports.2023;[Epub] CrossRef
Clinical manifestation of patients with isolated rapid eye movement sleep behavior disorder after modest-to-long disease duration Jung Kyung Hong, Jong-Min Kim, Ki-woong Kim, Ji Won Han, Soyeon Ahn, In-Young Yoon Sleep.2022;[Epub] CrossRef
Associations of cognitive dysfunction with motor and non-motor symptoms in patients with de novo Parkinson’s disease Kyum-Yil Kwon, Suyeon Park, Rae On Kim, Eun Ji Lee, Mina Lee Scientific Reports.2022;[Epub] CrossRef
Autonomic dysfunction in Parkinson's disease: Results from the Faroese Parkinson's disease cohort Aksel Berg, Sára Bech, Jan Aasly, Matthew J. Farrer, Maria Skaalum Petersen Neuroscience Letters.2022; 785: 136789. CrossRef
Prevalence of lower urinary tract symptoms, urinary incontinence and retention in Parkinson's disease: A systematic review and meta-analysis Fang-Fei Li, Yu-Sha Cui, Rui Yan, Shuang-Shuang Cao, Tao Feng Frontiers in Aging Neuroscience.2022;[Epub] CrossRef
White matter tract-specific microstructural disruption is associated with depressive symptoms in isolated RBD Jung-Ick Byun, Seunghwan Oh, Jun-Sang Sunwoo, Jung-Won Shin, Tae-Joon Kim, Jin-Sun Jun, Han-Joon Kim, Won Chul Shin, Joon-Kyung Seong, Ki-Young Jung NeuroImage: Clinical.2022; 36: 103186. CrossRef
Comparison of disease progression between brain-predominant Parkinson's disease versus Parkinson's disease with body-involvement phenotypes Dong-Woo Ryu, Sang-Won Yoo, Yoon-Sang Oh, Kwang-Soo Lee, Seunggyun Ha, Joong-Seok Kim Neurobiology of Disease.2022; 174: 105883. CrossRef
Corneal confocal microscopy differentiates patients with Parkinson’s disease with and without autonomic involvement Ning-Ning Che, Shuai Chen, Qiu-Huan Jiang, Si-Yuan Chen, Zhen-Xiang Zhao, Xue Li, Rayaz A. Malik, Jian-Jun Ma, Hong-Qi Yang npj Parkinson's Disease.2022;[Epub] CrossRef
Association of Nucleus Basalis of Meynert Functional Connectivity and Cognition in Idiopathic Rapid-Eye-Movement Sleep Behavior Disorder Jung-Ick Byun, Kwang Su Cha, Minah Kim, Woo-Jin Lee, Han Sang Lee, Jun-Sang Sunwoo, Jung-Won Shin, Tae-Joon Kim, Jin-Sun Jun, Han-Joon Kim, Won Chul Shin, Carlos H. Schenck, Sang Kun Lee, Ki-Young Jung Journal of Clinical Neurology.2022; 18(5): 562. CrossRef
White Matter Tract-Specific Microstructural Disruption is Associated with Depressive Symptoms in Isolated Rbd Jung-Ick Byun, Seunghwan Oh, Jun-Sang Sunwoo, Jung-Won Shin, Tae-Joon Kim, Jin-Sun Jun, Han-Joon Kim, Won Chul Shin, Joon-Kyung Seong, Ki-Young Jung SSRN Electronic Journal .2022;[Epub] CrossRef
Altered insular functional connectivity in isolated REM sleep behavior disorder: a data-driven functional MRI study Jung-Ick Byun, Kwang Su Cha, Minah Kim, Woo-Jin Lee, Han Sang Lee, Jun-Sang Sunwoo, Jung-Won Shin, Tae-Joon Kim, Jangsup Moon, Soon-Tae Lee, Keun-Hwa Jung, Kon Chu, Man-Ho Kim, Han-Joon Kim, Won Chul Shin, Sang Kun Lee, Ki-Young Jung Sleep Medicine.2021; 79: 88. CrossRef
Association of fall risk factors and non-motor symptoms in patients with early Parkinson’s disease Kyum-Yil Kwon, Suyeon Park, Eun Ji Lee, Mina Lee, Hyunjin Ju Scientific Reports.2021;[Epub] CrossRef
Impact of motor subtype on non‐motor symptoms and fall‐related features in patients with early Parkinson's disease Kyum‐Yil Kwon, Eun Ji Lee, Mina Lee, Hyunjin Ju, Kayeong Im Geriatrics & Gerontology International.2021; 21(5): 416. CrossRef
Extra-basal ganglia iron content and non-motor symptoms in drug-naïve, early Parkinson’s disease Minkyeong Kim, Seulki Yoo, Doyeon Kim, Jin Whan Cho, Ji Sun Kim, Jong Hyun Ahn, Jun Kyu Mun, Inyoung Choi, Seung-Kyun Lee, Jinyoung Youn Neurological Sciences.2021; 42(12): 5297. CrossRef
Clinical Assessment Scales in Autonomic Nervous System Disorders Eun Bin Cho, Ki-Jong Park Journal of the Korean Neurological Association.2021; 39(2 Suppl): 60. CrossRef
Cardiac sympathetic burden reflects Parkinson disease burden, regardless of high or low orthostatic blood pressure changes Sang-Won Yoo, Joong-Seok Kim, Yoon-Sang Oh, Dong-Woo Ryu, Seunggyun Ha, Ji-Yeon Yoo, Kwang-Soo Lee npj Parkinson's Disease.2021;[Epub] CrossRef
Understanding fatigue in progressive supranuclear palsy Jong Hyeon Ahn, Joomee Song, Dong Yeong Lee, Jinyoung Youn, Jin Whan Cho Scientific Reports.2021;[Epub] CrossRef
Validation of the Korean version of the composite autonomic symptom scale 31 in patients with Parkinson’s disease Jong Hyeon Ahn, Jin Myoung Seok, Jongkyu Park, Heejeong Jeong, Younsoo Kim, Joomee Song, Inyoung Choi, Jin Whan Cho, Ju-Hong Min, Byoung Joon Kim, Jinyoung Youn, Antonina Luca PLOS ONE.2021; 16(10): e0258897. CrossRef
Cardiac Autonomic Dysfunction Is Associated with Severity of REM Sleep without Atonia in Isolated REM Sleep Behavior Disorder Sooyeoun You, Kyoung Sook Won, Keun Tae Kim, Hyang Woon Lee, Yong Won Cho Journal of Clinical Medicine.2021; 10(22): 5414. CrossRef
Characteristics of Autonomic Dysfunction in Parkinson’s Disease: A Large Chinese Multicenter Cohort Study Zhou Zhou, Xiaoting Zhou, Xiaoxia Zhou, Yaqin Xiang, Liping Zhu, Lixia Qin, Yige Wang, Hongxu Pan, Yuwen Zhao, Qiying Sun, Qian Xu, Xinyin Wu, Xinxiang Yan, Jifeng Guo, Beisha Tang, Zhenhua Liu Frontiers in Aging Neuroscience.2021;[Epub] CrossRef
Autonomic Dysfunction in Parkinson's Disease: Results from the Faroese Parkinson's Disease Cohort Aksel Kambsskarð Berg, Sára Bech, Jan O. Aasly, Matthew J. Farrer, Maria Skaalum Petersen SSRN Electronic Journal .2021;[Epub] CrossRef
Subtypes of Sleep Disturbance in Parkinson's Disease Based on the Cross-Culturally Validated Korean Version of Parkinson's Disease Sleep Scale-2 Hui-Jun Yang, Han-Joon Kim, Seong-Beom Koh, Joong-Seok Kim, Tae-Beom Ahn, Sang-Myung Cheon, Jin Whan Cho, Yoon-Joong Kim, Hyeo-Il Ma, Mee Young Park, Jong Sam Baik, Phil Hyu Lee, Sun Ju Chung, Jong-Min Kim, In-Uk Song, Ji-Young Kim, Young-Hee Sung, Do You Journal of Clinical Neurology.2020; 16(1): 66. CrossRef
Risk Factors for Falls in Patients with de novo Parkinson’s Disease: A Focus on Motor and Non-Motor Symptoms Kyum-Yil Kwon, Mina Lee, Hyunjin Ju, Kayeong Im Journal of Movement Disorders.2020; 13(2): 142. CrossRef
Peripheral Blood Inflammatory Cytokines in Idiopathic REM Sleep Behavior Disorder Ryul Kim, Jin‐Sun Jun, Han‐Joon Kim, Ki‐Young Jung, Yong‐Won Shin, Tae‐Won Yang, Keun Tae Kim, Tae‐Joon Kim, Jung‐Ick Byun, Jun‐Sang Sunwoo, Beomseok Jeon Movement Disorders.2019; 34(11): 1739. CrossRef
Urinary Dysfunctions and Post-Void Residual Urine in Typical and Atypical Parkinson Diseases Yang-Hyun Lee, Jee-Eun Lee, Dong-Woo Ryu, Yoon-Sang Oh, Kwang-Soo Lee, Sung-Hoo Hong, Joong-Seok Kim Journal of Parkinson's Disease.2018; 8(1): 145. CrossRef
Rasch Analysis of the Clinimetric Properties of the Korean Dizziness Handicap Inventory in Patients with Parkinson Disease Da-Young Lee, Hui-Jun Yang, Dong-Seok Yang, Jin-Hyuk Choi, Byoung-Soo Park, Ji-Yun Park Research in Vestibular Science.2018; 17(4): 152. CrossRef
Clinical Characteristics of Parkinson’s Disease Developed from Essential Tremor Dong-Woo Ryu, Si-Hoon Lee, Yoon-Sang Oh, Jae-Young An, Jeong-Wook Park, In-Uk Song, Kwang-Soo Lee, Joong-Seok Kim Journal of Parkinson's Disease.2017; 7(2): 369. CrossRef
Objective The survival of Huntington’s disease (HD) patients is reported to be 15–20 years. However, most studies on the survival of HD have been conducted in patients without genetic confirmation with the possible inclusion of non-HD patients, and all studies have been conducted in Western countries. The survival of patients with HD in East Asia, where its prevalence is 10–50-fold lower compared with Western populations, has not yet been reported.
Methods Forty-seven genetically confirmed Korean HD patients from independent families were included in this retrospective medical record review study.
Results The mean age at onset among the 47 patients was 46.1 ± 14.0 years. At the time of data collection, 25 patients had died, and these patients had a mean age at death of 57.8 ± 13.7 years. The Kaplan-Meier estimate of the median survival from onset in the 47 patients was 14.5 years (95% confidence interval: 12.3–16.6). None of the following factors were associated with the survival time in the univariate Cox regression analysis: gender, age at onset, normal CAG repeat size, mutant CAG repeat size, and the absence or presence of non-motor symptoms at onset.
Conclusion This is the first Asian study on survival in HD patients. Survival in Korean HD patients may be shorter than that reported for Western populations, or at least is in the lower range of expected survival. A larger longitudinal observation study is needed to confirm the results found in this study.
Citations
Citations to this article as recorded by
Analysis of HTT CAG repeat expansion among healthy individuals and patients with chorea in Korea Ryul Kim, Moon-Woo Seong, Bumjo Oh, Ho Seop Shin, Jee-Soo Lee, Sangmin Park, Mihee Jang, Beomseok Jeon, Han-Joon Kim, Jee-Young Lee Parkinsonism & Related Disorders.2024; 118: 105930. CrossRef
Clinical and Genetic Characteristics Associated With Survival Outcome in Late-Onset Huntington’s Disease in South Korea Yun Su Hwang, Sungyang Jo, Gu-Hwan Kim, Jee-Young Lee, Ho-Sung Ryu, Eungseok Oh, Seung-Hwan Lee, Young Seo Kim, Sun Ju Chung Journal of Clinical Neurology.2024; 20(4): 394. CrossRef
A Practical Guide for Clinical Approach to Patients With Huntington’s Disease in Korea Chaewon Shin, Ryul Kim, Dallah Yoo, Eungseok Oh, Jangsup Moon, Minkyeong Kim, Jee-Young Lee, Jong-Min Kim, Seong-Beom Koh, Manho Kim, Beomseok Jeon Journal of Movement Disorders.2024; 17(2): 138. CrossRef
Increased 10-Year Prevalence of Huntington’s Disease in South Korea: An Analysis of Medical Expenditure Through the National Healthcare System Chan Young Lee, Jun-soo Ro, Hyemin Jung, Manho Kim, Beomseok Jeon, Jee-Young Lee Journal of Clinical Neurology.2023; 19(2): 147. CrossRef
Clustering and prediction of disease progression trajectories in Huntington's disease: An analysis of Enroll-HD data using a machine learning approach Jinnie Ko, Hannah Furby, Xiaoye Ma, Jeffrey D. Long, Xiao-Yu Lu, Diana Slowiejko, Rita Gandhy Frontiers in Neurology.2023;[Epub] CrossRef
Survival in Huntington’s disease and other young‐onset dementias Samantha M. Loi, Paraskevi Tsoukra, Emily Sun, Zhibin Chen, Pierre Wibawa, Maria di Biase, Sarah Farrand, Dhamidhu Eratne, Wendy Kelso, Andrew Evans, Mark Walterfang, Dennis Velakoulis International Journal of Geriatric Psychiatry.2023;[Epub] CrossRef
Functional Intercellular Transmission of miHTT via Extracellular Vesicles: An In Vitro Proof-of-Mechanism Study Roberto D. V. S. Morais, Marina Sogorb-González, Citlali Bar, Nikki C. Timmer, M. Leontien Van der Bent, Morgane Wartel, Astrid Vallès Cells.2022; 11(17): 2748. CrossRef
Huntington's disease: Mortality and risk factors in an Australian cohort Emily Sun, Matthew Kang, Pierre Wibawa, Vivian Tsoukra, Zhibin Chen, Sarah Farrand, Dhamidhu Eratne, Wendy Kelso, Andrew Evans, Mark Walterfang, Dennis Velakoulis, Samantha M. Loi Journal of the Neurological Sciences.2022; 442: 120437. CrossRef
Huntington’s disease in Turkey: genetic counseling, clinical features, and outcome Yesim Sucullu Karadag, Busranur Erozan Cavdarli, Rabia Nazik Yuksel Neurological Research.2021; 43(5): 381. CrossRef
Validation of diagnostic codes and epidemiologic trends of Huntington disease: a population-based study in Navarre, Spain Esther Vicente, Ainara Ruiz de Sabando, Fermín García, Itziar Gastón, Eva Ardanaz, María A. Ramos-Arroyo Orphanet Journal of Rare Diseases.2021;[Epub] CrossRef
Epidemiology of Huntington disease in Cyprus: A 20‐year retrospective study C.A. Demetriou, A. Heraclides, C. Salafori, G.A. Tanteles, K. Christodoulou, Y. Christou, E. Zamba‐Papanicolaou Clinical Genetics.2018; 93(3): 656. CrossRef
Population-specific genetic modification of Huntington's disease in Venezuela Michael J. Chao, Kyung-Hee Kim, Jun Wan Shin, Diane Lucente, Vanessa C. Wheeler, Hong Li, Jared C. Roach, Leroy Hood, Nancy S. Wexler, Laura B. Jardim, Peter Holmans, Lesley Jones, Michael Orth, Seung Kwak, Marcy E. MacDonald, James F. Gusella, Jong-Min L PLOS Genetics.2018; 14(5): e1007274. CrossRef
Hereditary ataxia is a heterogeneous disorder characterized by progressive ataxia combined with/without peripheral neuropathy, extrapyramidal symptoms, pyramidal symptoms, seizure, and multiple systematic involvements. More than 35 autosomal dominant cerebellar ataxias have been designated as spinocerebellar ataxia, and there are 55 recessive ataxias that have not been named systematically. Conducting genetic sequencing to confirm a diagnosis is difficult due to the large amount of subtypes with phenotypic overlap. The prevalence of hereditary ataxia can vary among countries, and estimations of prevalence and subtype frequencies are necessary for planning a diagnostic strategy in a specific population. This review covers the various hereditary ataxias reported in the Korean population with a focus on the prevalence and subtype frequencies as the clinical characteristics of the various subtypes.
Citations
Citations to this article as recorded by
MRl and MRS hints for the differentiation of cerebellar multiple system atrophy from spinocerebellar ataxia type II Hung-Chieh Chen, Li-Hua Lee, Jiing-Feng Lirng, Bing-wen Soong Heliyon.2024; 10(7): e29265. CrossRef
Discovery of a de novo ITPR1 missense mutation in a patient with early‐onset cerebellar ataxia: A rare case report of spinocerebellar ataxia 29 Jae In Lee, Ja Young Choi, Shin‐Seung Yang Molecular Genetics & Genomic Medicine.2024;[Epub] CrossRef
Placebo response in degenerative cerebellar ataxias: a descriptive review of randomized, placebo-controlled trials Ji-Hyun Choi, Chaewon Shin, Han-Joon Kim, Beomseok Jeon Journal of Neurology.2022; 269(1): 62. CrossRef
New Perspectives of Gene Therapy on Polyglutamine Spinocerebellar Ataxias: From Molecular Targets to Novel Nanovectors Fabiola V. Borbolla-Jiménez, María Luisa Del Prado-Audelo, Bulmaro Cisneros, Isaac H. Caballero-Florán, Gerardo Leyva-Gómez, Jonathan J. Magaña Pharmaceutics.2021; 13(7): 1018. CrossRef
Serum neurofilament light chain as a severity marker for spinocerebellar ataxia Hye-Rim Shin, Jangsup Moon, Woo-Jin Lee, Han Sang Lee, Eun Young Kim, Seoyi Shin, Soon-Tae Lee, Keun-Hwa Jung, Kyung-Il Park, Ki-Young Jung, Sang Kun Lee, Kon Chu Scientific Reports.2021;[Epub] CrossRef
Essential tremor: the most common form of cerebellar degeneration? Elan D. Louis, Phyllis L. Faust Cerebellum & Ataxias.2020;[Epub] CrossRef
Identifying SYNE1 ataxia and extending the mutational spectrum in Korea Ji Sun Kim, Ah Reum Kim, Jinyoung Youn, Chung Lee, Nam-Soon Kim, Woong-Yang Park, Jong Kyu Park, Nayoung K.D. Kim, Jin Whan Cho Parkinsonism & Related Disorders.2019; 58: 74. CrossRef
Association of ATXN2 intermediate-length CAG repeats with amyotrophic lateral sclerosis correlates with the distributions of normal CAG repeat alleles among individual ethnic populations Hiroya Naruse, Takashi Matsukawa, Hiroyuki Ishiura, Jun Mitsui, Yuji Takahashi, Hiroki Takano, Jun Goto, Tatsushi Toda, Shoji Tsuji neurogenetics.2019; 20(2): 65. CrossRef
Heterogeneous nonataxic phenotypes of spinocerebellar ataxia in a Taiwanese population Szu‐Ju Chen, Ni‐Chung Lee, Yin‐Hsiu Chien, Wuh‐Liang Hwu, Chin‐Hsien Lin Brain and Behavior.2019;[Epub] CrossRef
Differential value of brain magnetic resonance imaging in multiple system atrophy cerebellar phenotype and spinocerebellar ataxias Minkyeong Kim, Jong Hyeon Ahn, Yoonsu Cho, Ji Sun Kim, Jinyoung Youn, Jin Whan Cho Scientific Reports.2019;[Epub] CrossRef
The Etiologies of Chronic Progressive Cerebellar Ataxia in a Korean Population Ji Sun Kim, Soonwook Kwon, Chang-Seok Ki, Jinyoung Youn, Jin Whan Cho Journal of Clinical Neurology.2018; 14(3): 374. CrossRef
Cross-cultural adaptation and validation of the International Cooperative Ataxia Rating Scale (ICARS) to Brazilian Portuguese Fernanda Aparecida Maggi, Pedro Braga-Neto, Hsin Fen Chien, Maria Thereza Drumond Gama, Flávio Moura Rezende Filho, Maria Luiza Saraiva-Pereira, Laura Bannach Jardim, Mariana Callil Voos, José Luiz Pedroso, Orlando Graziani Povoas Barsottini Arquivos de Neuro-Psiquiatria.2018; 76(10): 674. CrossRef
The c-Abl inhibitor, nilotinib, as a potential therapeutic agent for chronic cerebellar ataxia Woo-Jin Lee, Jangsup Moon, Tae-Joon Kim, Jin-Sun Jun, Han Sang Lee, Young Jin Ryu, Soon-Tae Lee, Keun-Hwa Jung, Kyung-Il Park, Ki-Young Jung, Manho Kim, Sang Kun Lee, Kon Chu Journal of Neuroimmunology.2017; 309: 82. CrossRef
Genetic Variants Associated with Episodic Ataxia in Korea Kwang-Dong Choi, Ji-Soo Kim, Hyo-Jung Kim, Ileok Jung, Seong-Hae Jeong, Seung-Han Lee, Dong Uk Kim, Sang-Ho Kim, Seo Young Choi, Jin-Hong Shin, Dae-Seong Kim, Kyung-Pil Park, Hyang-Sook Kim, Jae-Hwan Choi Scientific Reports.2017;[Epub] CrossRef
Ataxia with Oculomotor Apraxia Type 1 without Oculomotor Apraxia: A Case Report Minwoo Lee, Nan Young Kim, Jin Young Huh, Young Eun Kim, Yun Joong Kim Journal of Clinical Neurology.2016; 12(1): 126. CrossRef
The prevalence of Parkinson’s disease (PD) appears to be lower in Asia compared to the Western world. It is unclear if this is related to the ubiquitous use of traditional medicine in Eastern healthcare, but the use of complementary and alternative medicine (CAM) modalities in countries like Korea may be as high as 76%. Among patients with PD, herbal medicines, health supplement foods, and acupuncture are interventions which are increasingly used throughout the world. Countries like Korea, China, India, and Japan have long embraced and incorporated traditional medicine into modern management of conditions such as PD, but research into various CAM modalities remains in its infancy limiting evidence-based recommendations for many treatments. We reviewed the literature on CAM treatments for PD, focusing on mind-body interventions and natural products. Based on evidence limited to randomized-controlled trials we found that mind-body interventions are generally effective forms of physical activity that are likely to foster good adherence and may reduce disability associated with PD. Based on the current data, modalities like Tai Chi and dance are safe and beneficial in PD, but better studies are needed to assess the effects of other frequently used modalities such as yoga and acupuncture. Furthermore, despite centuries of experience using medicinal herbs and plants in Eastern countries, and despite substantial preclinical data on the beneficial effects of nutritional antioxidants as neuroprotective agents in PD, there is insufficient clinical evidence that any vitamin, food additive, or supplement, can improve motor function or delay disease progression in PD.
Citations
Citations to this article as recorded by
Challenges in Managing Nonmotor Symptoms of Parkinson's Disease in Low‐Resourced Settings with Unavailability of Newer Drugs Zakiyah Aldaajani, Hanan Khalil Movement Disorders Clinical Practice.2024; 11(2): 123. CrossRef
Effectiveness and Safety of Meridian Activation Remedy System for Alleviating Motor Symptoms in Parkinson’s Disease: an Observational Study InWoo Choi, Sangsoo Park, Seung Hyun Lee, Jeong-Woo Seo, In-Chan Seol, Yoon-Sik Kim, Miso S. Park, Horyong Yoo Journal of Acupuncture and Meridian Studies.2024; 17(2): 55. CrossRef
Wellness in Parkinson’s Disease: A Framework for Management Using a Holistic Culturally Sensitive Approach Indu Subramanian, Kate Perepezko, Britt Stone, Ray K Chaudhuri, Gregory M Pontone US Neurology.2023; 19(1): 8. CrossRef
A novel decision making technique based on spherical hesitant fuzzy Yager aggregation information: application to treat Parkinson's disease Muhammad Naeem, Aziz Khan, Shahzaib Ashraf, Saleem Abdullah, Muhammad Ayaz, Nejib Ghanmi AIMS Mathematics.2022; 7(2): 1678. CrossRef
A Case Report of Acupuncture Treatment in a Patient with Parkinson’s Disease Tremor Hagdong Kim, Daewon Shin Journal of Korean Medical Society of Acupotomology.2022; 6(1): 81. CrossRef
Effectiveness and safety of herbal medicine Ukgansan for clinical symptoms in Parkinson's disease: A pilot, randomized, assessor-blinded clinical trial Chul Jin, Ki-Ho Cho, Seungwon Kwon, Han-Gyul Lee, Tae-Hun Kim, Woo-Sang Jung, Sang-Kwan Moon, Seung-Yeon Cho, Byoung-Kab Kang, Jung-Mi Park, Hi-Joon Park, Chang-Nam Ko Frontiers in Neurology.2022;[Epub] CrossRef
Quantitative analysis of cerebrovascular characteristics of Parkinson’s disease treated with acupuncture based on magnetic resonance angiography Yuan Yang, Le He, Suhua Miao, Rongsong Zhou, Yuqi Zhang, Yu Ma Brain Science Advances.2021; 7(2): 141. CrossRef
Mind the gap: Inequalities in mental health care and lack of social support in Parkinson disease Indu Subramanian, Jared T. Hinkle, K. Ray Chaudhuri, Zoltan Mari, Hubert H. Fernandez, Gregory M. Pontone Parkinsonism & Related Disorders.2021; 93: 97. CrossRef
Review of Studies on Clinical Trials of Acupuncture Treatment for Parkinson’s Disease Using Neuroimaging Methods Dong Hyuk Lee The Journal of Internal Korean Medicine.2020; 41(1): 59. CrossRef
Effects of Acupuncture Treatment on Functional Brain Networks of Parkinson’s Disease Patients during Treadmill Walking: An fNIRS Study Seung Hyun Lee, Sang-Soo Park, Jung-hee Jang, Sang Hyeon Jin, Young-Soo Baik, Ho-Ryong Yoo Applied Sciences.2020; 10(24): 8954. CrossRef
Effectiveness of Integrative Therapy for Parkinson’s Disease Management Yeonju Woo, Min Kyung Hyun Frontiers in Aging Neuroscience.2019;[Epub] CrossRef
Treatment of psychiatric disturbances in hypokinetic movement disorders Isabella Berardelli, Daniele Belvisi, Massimo Pasquini, Andrea Fabbrini, Federica Petrini, Giovanni Fabbrini Expert Review of Neurotherapeutics.2019; 19(10): 965. CrossRef
The effect of Tai Chi and Qigong on health-related quality of life in Parkinson’s disease: a systematic review and meta-analysis of systematic reviews Oznur Fidan, Gulce Kallem Seyyar, Bahar Aras, Ertugrul Colak, Ozgen Aras International Journal of Rehabilitation Research.2019; 42(3): 196. CrossRef
Forestalling the Epidemics of Parkinson's Disease Through Plant-Based Remedies Ines Banjari, Tihana Marček, Svetlana Tomić, Viduranga Y. Waisundara Frontiers in Nutrition.2018;[Epub] CrossRef
Novel Neuroprotective Effects of Melanin-Concentrating Hormone in Parkinson’s Disease Ji-Yeun Park, Seung-Nam Kim, Junsang Yoo, Jaehwan Jang, Ahreum Lee, Ju-Young Oh, Hongwon Kim, Seung Tack Oh, Seong-Uk Park, Jongpil Kim, Hi-Joon Park, Songhee Jeon Molecular Neurobiology.2017; 54(10): 7706. CrossRef
Ethnobiological treatments of neurological conditions in the Chota Nagpur Plateau, India Abhijit Dey, Partha Gorai, Anuradha Mukherjee, Raghunath Dhan, Biplob Kumar Modak Journal of Ethnopharmacology.2017; 198: 33. CrossRef
Acacetin inhibits neuronal cell death induced by 6-hydroxydopamine in cellular Parkinson’s disease model Sang Min Kim, Yong Joo Park, Myoung-Sook Shin, Ha-Ryong Kim, Min Jae Kim, Sang Hun Lee, Seung Pil Yun, Seung-Hwan Kwon Bioorganic & Medicinal Chemistry Letters.2017; 27(23): 5207. CrossRef
The Effects of Whole Body Periodic Acceleration on Non-Motor Symptoms in Persons with Parkinson’s disease: A Pilot Study Southard Veronica Journal of Novel Physiotherapy and Physical Rehabilitation.2017; : 077. CrossRef
The effects of a mindfulness-based lifestyle program for adults with Parkinson’s disease: a mixed methods, wait list controlled randomised control study Jenny Advocat, Joanne Enticott, Brooke Vandenberg, Craig Hassed, Jennifer Hester, Grant Russell BMC Neurology.2016;[Epub] CrossRef
A Clinical Study of Integrating Acupuncture and Western Medicine in Treating Patients with Parkinson's Disease Fang-Pey Chen, Ching-Mao Chang, Jing-Huei Shiu, Jen-Hwey Chiu, Ta-Peng Wu, Jen-Lin Yang, Yen-Ying Kung, Fun-Jou Chen, Chang-Ming Chern, Shinn-Jang Hwang The American Journal of Chinese Medicine.2015; 43(03): 407. CrossRef
Levodopa in Mucuna pruriens and its degradation Haridas Pulikkalpura, Rajani Kurup, Paravanparampil Jacob Mathew, Sabulal Baby Scientific Reports.2015;[Epub] CrossRef