Approximately 30% of primary intraspinal tumors originate from Schwann cells. While both schwannomas and neurofibromas are derived from Schwann cells, they show some distinguishing characteristics. They are usually solitary lesions, except in Von Recklinghausen’s disease. Schwannomas are usually solid or heterogeneously solid tumors and are commonly observed as intradural extramedullary spinal tumors.
3,4 We have described a case of lobulated Schwannoma in the cervical region that intradurally extended over a long segment from C2 to C7 and also showed extradural extension. Schwannomas are benign tumors with a slow growth rate, the diagnosis of extracranial schwannomas may pose a challenge to neurologists. Patients with such schwannomas rarely show pain and neurological symptoms, and these symptoms become evident only at the advanced stages.
4 This case showed a striking paucity of symptoms in spite of the large size of the tumor. Preoperative diagnosis is sometimes difficult and differential diagnoses are widely variable. Surgical treatment does not always fully eliminate the tumor, the possibility of neurological sequelae should be explained to the patient during the preoperative interview.
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Clonus, presented behaviorally as rhythmic distal joints oscillation, is a common pathology that occurs secondary to spinal cord injury and other neurological disabilities.
5 The underlying mechanism of clonus is therefore still unclear and controversial. The prevailing one is that clonus results from recurrent activation of stretch reflexes. Szumski et al. demonstrated that unsustained clonus could be prolonged by Jendrassik’s maneuver.
6 They concluded that in clonus the spindles were abnormally sensitive and that the motoneurons particularly important for manifesting clonus were the dynamic fusimotor neurons. Hagbarth et al. demonstrated that Ia afferent discharges precede clonic EMG bursts but were not activated during muscle contraction.
7 They concluded that as the muscle relaxes, muscles spindle stretches and regenerates EMG activity resulting in repeated oscillatory movement. Rack et al. also supported the notion that clonus is caused by self-sustaining oscillation of a stretch reflex pathway because the frequency of clonus may be altered by changing the mechanical load acting at the joint.
8 An alternative hypothesis is that clonus results from the action of central oscillator. Walsh and Wright have reported similar frequencies of clonus among ankle, knee, and wrist muscles.
9 Dimitrijevic et al. reported that ankle clonus frequency was unchanged by altering the frequency of tendon taps, cooling, adding a mass to the foot, moving the foot through viscous solution, and direct movement opposition.
2 This study suggested clonus to be primarily dependent on the activity of a central generator within spinal cord which rhythmically activates the alpha motoneurones. The other study showed the mechanism underlying clonus after spinal cord injury is not solely related to recurrent muscle stretch. They concluded that clonus is the frequent presentation of intrinsic oscillating spinal neuronal networks after chronic loss of supraspinal input and diminution of load-related sensory input.
5 Therefore, we also suggest that the cervical schwannoma observed in our case could be responsible for deprivation of supraspinal control of the stretch reflex loops.
The symptoms in this patient were considered similar to action tremors in which rhythmic oscillations of a limb occur spontaneously during voluntary movement. Although action tremors are usually observed in cerebellar, task-specific, dystonic, or Holmes tremor, and they may be rarely associated with partial lesions in the descending motor pathways.
10 However, our patient had spasticity in the upper limbs with exaggerated tendon jerks and passive stretch-induced clonus. The case we report is very similar to the description of “action induced clonus mimicking tremor” by Fravix et al.
10 However, in our case, duration of the symptom was as long as the essential tremor. This point induced a clinician to insufficient neurologic examination and misdiagnosis. Usually clonus is rarely misinterpreted as tremor. On clinical examination, passive stretching of the muscles increases the force of clonus but not of tremor.
12 Even though essential tremor is a common disease, clinician have to do sufficient neurologic examination considering differential diagnosis.