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JMD : Journal of Movement Disorders



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Hypomania Induced by Subthalamic Nucleus Stimulation in a Parkinson’s Disease Patient: Does It Suggest a Dysfunction of the Limbic Circuit?
Ji Seon Kim, Hee Jin Kim, Ji-Young Lee, Jong Min Kim, Ji Young Yun, Beom S. Jeon
J Mov Disord. 2012;5(1):14-17.
  • 13,380 View
  • 68 Download
  • 7 Crossref
AbstractAbstract PDF

The aim of this report was to describe a case of hypomania after deep brain stimulation of the subthalamic nucleus (STN DBS) in a Parkinson’s disease (PD) patient. 59-year-old man with a 15-year history of PD underwent bilateral implantation of electrodes to the STN. Immediately after surgery, his motor function was markedly improved and his mood was elevated to hypomania. Fusion images of the preoperative MRI and postoperative CT scan showed that the electrodes were located in the medial portion of the STN. In this case, behavioral mood change was related to the deep brain stimulation. Moreover, the anatomical location and the functional alteration of the STN after the DBS surgery might be related to the regulatory system of the associative and limbic cortico-subcortical circuits.


Citations to this article as recorded by  
  • Architecture of the subthalamic nucleus
    Asheeta A. Prasad, Åsa Wallén-Mackenzie
    Communications Biology.2024;[Epub]     CrossRef
  • Treating addiction with deep brain stimulation: Ethical and legal considerations
    Clara Lo, Mansee Mane, Jee Hyun Kim, Michael Berk, Richard R. Sharp, Kendall H. Lee, Jason Yuen
    International Journal of Drug Policy.2023; 113: 103964.     CrossRef
  • The anatomo-functional organization of the hyperdirect cortical pathway to the subthalamic area using in vivo structural connectivity imaging in humans
    Gizem Temiz, Sophie B. Sébille, Chantal Francois, Eric Bardinet, Carine Karachi
    Brain Structure and Function.2020; 225(2): 551.     CrossRef
  • Hypomania and saccadic changes in Parkinson’s disease: influence of D2 and D3 dopaminergic signalling
    Esther A. Pelzer, Barbara Dillenburger, Sophie Grundmann, Vladimir Iliaev, Sophie Aschenberg, Corina Melzer, Martin Hess, Gereon R. Fink, Carsten Eggers, Marc Tittgemeyer, Lars Timmermann
    npj Parkinson's Disease.2020;[Epub]     CrossRef
  • Overlapping and distinct neural metabolic patterns related to impulsivity and hypomania in Parkinson’s disease
    Frank Schwartz, Masoud Tahmasian, Franziska Maier, Luisa Rochhausen, Kim L. Schnorrenberg, Fateme Samea, Joseph Seemiller, Mojtaba Zarei, Christian Sorg, Alexander Drzezga, Lars Timmermann, Thomas D. Meyer, Thilo van Eimeren, Carsten Eggers
    Brain Imaging and Behavior.2019; 13(1): 241.     CrossRef
  • Affective modulation of the associative-limbic subthalamic nucleus: deep brain stimulation in obsessive–compulsive disorder
    Mircea Polosan, Fabien Droux, Astrid Kibleur, Stephan Chabardes, Thierry Bougerol, Olivier David, Paul Krack, Valerie Voon
    Translational Psychiatry.2019;[Epub]     CrossRef
  • Beyond Emotions: Oscillations of the Amygdala and Their Implications for Electrical Neuromodulation
    Lisa-Maria Schönfeld, Lars Wojtecki
    Frontiers in Neuroscience.2019;[Epub]     CrossRef
Restlessness with Manic Episodes due to Right Parietal Infarction
Suk Yun Kang, Jong Won Paik, Young Ho Sohn
J Mov Disord. 2010;3(1):22-24.
  • 15,363 View
  • 94 Download
  • 4 Crossref
AbstractAbstract PDF

Mood disorders following acute stroke are relatively common. However, restlessness with manic episodes has rarely been reported. Lesions responsible for post-stroke mania can be located in the thalamus, caudate nucleus, and temporal and frontal lobes. We present a patient who exhibited restlessness with manic episodes after an acute infarction in the right parietal lobe, and summarize the case reports involving post-stroke mania. The right parietal stroke causing mania in our case is a novel observation that may help us to understand the mechanisms underlying restlessness with mania following acute stroke.


Citations to this article as recorded by  
  • Restlessness with manic episodes induced by right-sided multiple strokes after COVID-19 infection: A case report
    Takahiko Nagamine
    Brain Circulation.2023; 9(2): 112.     CrossRef
  • Poststroke Mania During the COVID-19 Pandemic
    Takahiko Nagamine
    Journal of Nervous & Mental Disease.2023; 211(12): 979.     CrossRef
  • Management of psychiatric disorders in patients with stroke and traumatic brain injury
    Gautam Saha, Kaustav Chakraborty, Amrit Pattojoshi
    Indian Journal of Psychiatry.2022; 64(8): 344.     CrossRef
  • Post stroke delirium
    M. A. Savina
    Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova.2014; 114(12. Vyp. 2): 19.     CrossRef

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