aDepartments of Neurology, Inje University College of Medicine, Busan, Korea
bRadiology, Pusan Paik Hospital, Inje University College of Medicine, Busan, Korea
cClinical Trial Center, Inje University, Pusan Paik Hospital, Busan, Korea
Copyright © 2009 The Korean Movement Disorder Society
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Dorsal putamen | Middle cerebellar peduncle | |
---|---|---|
PD | 0.80 ± 0.08 | 0.69 ± 0.08 |
MSA-p | 0.9 ± 0.13 | 0.98 ± 0.17 |
NC | 0.76 ± 0.04 | 0.75 ± 0.06 |
PD versus MSA-p (*p) | 0.03 | 0.0001 |
MSA-p versus NC (*p) | 0.005 | 0.001 |
PD versus NC (*p) | 0.7 | 0.66 |
% | Sensitivity | Specificity | PPV | NPV |
---|---|---|---|---|
DP rADC | 66.67 | 80 | 80 | 66.67 |
MCP rADC | 91.67 | 100 | 100 | 90.91 |
optimal cut off level of DP rADC≥0. 8225×10−3 mm2/s; optimal cut off level of MCP rADC ≥0.834×10−3 mm2/s. NPV: negative-predictive value, DWI: diffusion-weighted imaging, MSA-p: Parkinson variant of multiple system atrophy, PD: Parkinson’s disease, PPV: positive predictive value, DP: dorsal putamen, rADC: regional apparent diffusion coefficient, NPV: negative predictive value, MCP: middle cerebellar peduncles.
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PD | MSA-p | NC | p | |
---|---|---|---|---|
Sex (M/F) | 5/7 | 5/5 | 4/6 | 0.09 |
Age (year) | 65.7 ± 10.88 | 63.6 ± 8.25 | 62.1 ± 9.77 | 0.715 |
Onset age (year) | 63.2 ± 10.55 | 61.7 ± 1.78 | 0.458 | |
Disease duration (mo) | 30.4 ± 22.03 | 23.6 ± 12.82 | 0.148 | |
UPDRS scores | 32.7 ± 15.42 | 30.3 ± 12.26 | 0.636 | |
H & Y stage | 2.0 ± 0.78 | 2.5 ± 0.97 | 0.262 |
Dorsal putamen | Middle cerebellar peduncle | |
---|---|---|
PD | 0.80 ± 0.08 | 0.69 ± 0.08 |
MSA-p | 0.9 ± 0.13 | 0.98 ± 0.17 |
NC | 0.76 ± 0.04 | 0.75 ± 0.06 |
PD versus MSA-p ( |
0.03 | 0.0001 |
MSA-p versus NC ( |
0.005 | 0.001 |
PD versus NC ( |
0.7 | 0.66 |
% | Sensitivity | Specificity | PPV | NPV |
---|---|---|---|---|
DP rADC | 66.67 | 80 | 80 | 66.67 |
MCP rADC | 91.67 | 100 | 100 | 90.91 |
Comparison | PD | MSA-p |
---|---|---|
DP rADC versus | ||
| ||
Onset age | r=0.196, p=0.564 | r=0.163, p=0.652 |
Disease duration | r=0.252, p=0.454 | r=0.444, p=0.199 |
UPDRS scores | r=0.467, p=0.147 | r=−0.593, p=0.137 |
H &Y stage | r=0.216, p=0.524 | r=−0.272, p=0.447 |
Rigidity | r=0.609, p=0.057 | r=−0.654, p=0.06 |
Rest tremor | r=−0.403, p=0.219 | r=−0.022, p=0.952 |
Bradykinesia | r=0.567, p=0.069 | r=−0.02, p=0.956 |
Axial symptoms | ||
Speech | r=0.293, p=0.382 | r=−0.346, p=0.327 |
Facial expression | r=0.434, p=0.183 | r=−0.216, p=0.548 |
Arise from chair | r=0.469, p=0.146 | r=−0.216, p=0.548 |
Posture | r=0.17, p=0.617 | r=−0.416, p=0.232 |
Gait | r=0.627, p=0.059 | r=−0.196, p=0.587 |
Postural reflex | r=0.362, p=0.274 | r=−0.214, p=0.554 |
| ||
MCP rADC versus | ||
| ||
Onset age | r=−0.16, p=0.639 | r=−0.502, p=0.139 |
Disease duration | r=0.659, p=0.057 | r=−0.178, p=0.623 |
H &Y stage | r=−0.52, p=0.101 | r=−0.272, p=0.448 |
UPDRS scores | r=−0.418, p=0.2 | r=−0.364, p=0.3 |
Rigidity | r=−0.209, p=0.536 | r=−0.419, p=0.228 |
Rest tremor | r=−0.424, p=0.194 | r=−0.17, p=0.639 |
Bradykinesia | r=−0.215, p=0.525 | r=−0.362, p=0.304 |
Axial symptoms | ||
Speech | r=−0.23, p=0.497 | r=0.318, p=0.371 |
Facial expression | r=−0.399, p=0.224 | r=−0.291, p=0.415 |
Arise from chair | r=−0.507, p=0.111 | r=−0.19, p=0.599 |
Posture | r=−0.254, p=0.452 | r=−0.462, p=0.179 |
Gait | r=−0.314, p=0.347 | r=−0.407, p=0.243 |
Postural reflex | r=0.765, p=0.06 | r=−0.492, p=0.148 |
PD: Parkinson’s disease, MSA-p: Parkinson variant of multiple system atrophy, NC: normal control, UPDRS: United Parkinson’s Disease Rating Scale.
rADC values (×10−3 mm2/s) are reported as mean value. significance (p) for pair-wise comparison between groups was corrected by Bonferroni. rADC: regional apparent diffusion coefficient, MSA-p: Parkinson variant of multiple system atrophy, PD: Parkinson’s disease, NC: normal control.
optimal cut off level of DP rADC≥0. 8225×10−3 mm2/s; optimal cut off level of MCP rADC ≥0.834×10−3 mm2/s. NPV: negative-predictive value, DWI: diffusion-weighted imaging, MSA-p: Parkinson variant of multiple system atrophy, PD: Parkinson’s disease, PPV: positive predictive value, DP: dorsal putamen, rADC: regional apparent diffusion coefficient, NPV: negative predictive value, MCP: middle cerebellar peduncles.
The Spearman correlation was used.