Pre-DBS modified Tremor/Postural instability and gait difficulty score ratio as indicator of short-term outcome of subthalamic nucleus DBS in Parkinson’s disease

Chakradhar Reddy; Kanchana Pillai; Shejoy Joshua; Anup Nair; Harshad Chavotiya; Manas Chacko; Asha Kishore

doi:10.14802/jmd.24175

Brief communication Pre-DBS modified Tremor/Postural instability and gait difficulty score ratio as indicator of short-term outcome of subthalamic nucleus DBS in Parkinson’s disease: Chakradhar Reddy¹, Kanchana Pillai¹, Shejoy Joshua¹, Anup Nair¹, Harshad Chavotiya¹, Manas Chacko¹, Asha Kishore¹; DOI: https://doi.org/10.14802/jmd.24175 [Accepted]
Published online: January 2, 2025

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Parkinson and Movement Disorder Centre, Centre of Excellence in Neurosciences, Aster Medcity, Kochi, India

Corresponding author: Asha Kishore,
Email: asha.kishore@asterdmhealthcare.com

Received: 5 August 2024 • Revised: 8 November 2024 • Accepted: 2 January 2025

Abstract

Purpose
-The outcomes of motor and non-motor features of Parkinson’s disease (PD) following DBS vary among its subtypes. We tested whether pre-operative motor subtyping using the modified Tremor/PIGD ratio, could indicate the short-term motor, non-motor and quality of life (QOL) outcomes of STN-DBS.
Method
In this prospective study, 39 consecutive STN-DBS cases were assessed in Drug-OFF state before surgery and subtyped using the ratio of tremor and PIGD scores (T/P ratio). 6 months after surgery patients were reassessed in Stimulation ON-Drug OFF state and the percentage change in motor, non-motor and QOL scores (PDQ39) was calculated.
Results
The modified T/P ratio had a moderate, positive correlation with the percentage change in scores of UPDRS III in OFF, sum of cardinal motor signs, non-motor symptoms scale (NMSS) and quality of life (PDQ39).
Conclusion
Preoperative PD motor subtyping can be used as an indicator of the short-term, outcomes of STN-DBS in PD.