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Brief communication Efficacy and safety of zolpidem for musician’s dystonia
Shiro Horisawa1corresp_icon, Kilsoo Kim1, Masato Murakami1, Masahiko Nishitani1, Takakazu Kawamata1, Takaomi Taira1

DOI: https://doi.org/10.14802/jmd.24121 [Accepted]
Published online: July 1, 2024
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Department of Neurosurgery, Tokyo Women’s Medical University, Tokyo, Japan
Corresponding author:  Shiro Horisawa, Tel: +81-3-3353-8111, 
Email: neurosurgery21@yahoo.co.jp
Received: 20 May 2024   • Revised: 10 June 2024   • Accepted: 28 June 2024

Background
The efficacy and safety of zolpidem in treating musician’s dystonia are not well understood.
Objective
We aimed to retrospectively investigate the efficacy and safety of zolpidem for musician’s dystonia.
Methods
We retrospectively reviewed medical records between January 2021 and December 2023 to identify patients with musician’s dystonia who had been prescribed zolpidem. The Tubiana’s musician’s dystonia rating scale (range, 1-5; lower scores indicating greater severity) was used to evaluate musician’s dystonia.
Results
Fifteen patients were included in this study. The mean effective dose of zolpidem was 5.3±2.0 mg. The mean effective duration of zolpidem was 4.3±1.2 h. With zolpidem administration, the Tubiana’s musician’s dystonia rating scale score significantly improved from 2.2±1.0 to 4.3±0.8 (48.9% improvement, p<0.001). Two patients (13.3%) discontinued the drug owing to unsatisfactory results or sleepiness.
Conclusion
This study suggests that zolpidem may be an alternative treatment option for musician’s dystonia.

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