1Department of Neurology, Yongin Severance Hospital, Yonsei University Health System, Yongin, Korea
2Department of Neurology, Yonsei University College of Medicine, Seoul, Korea
3Department of Laboratory Medicine, Yongin Severance Hospital, Yonsei University Health System, Yongin, Korea
Copyright © 2024 The Korean Movement Disorder Society
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Ethics Statement
This study was performed in accordance with the tenets of the Declaration of Helsinki after being approved by the Institutional Review Board and Ethics Committee of the Yongin Severance Hospital (9-2024-0012). Informed consent was obtained from the patient.
Conflicts of Interest
The authors have no financial conflicts of interest.
Funding Statement
This research was supported by a grant of the Korea Health Technology R&D Project through the Korean Healthy Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: RS-2023-00265377).
Author Contributions
Conceptualization: Yun Joong Kim. Data curation: Yeo Jun Yoon, Yun Joong Kim. Formal analysis: Jin Ju Kim, Chan Wook Park, Seok Jong Chung, Yun Joong Kim. Funding acquisition: Yun Joong Kim. Investigation: Chan Wook Park, Yun Joong Kim. Methodology: Chan Wook Park, Yun Joong Kim. Project administration: Yun Joong Kim. Resources: Yun Joong Kim. Software: Chan Wook Park, Jin Ju Kim. Supervision: Yun Joong Kim. Validation: Chan Wook Park, Yun Joong Kim. Visualization: Yeo Jun Yoon, Chan Wook Park. Writing—original draft: Yeo Jun Yoon. Writing—review & editing: Jin Ju Kim, Chan Wook Park, Seok Jong Chung, Yun Joong Kim.
Pasanen et al., [5] 2014 | Martikainen et al., [8] 2015 | Picillo et al., [7] 2018 | Our case | |
---|---|---|---|---|
Ethnicity/nation | Finnish/Finland | Finnish/Finland | Mixed Dutch, Scottish, and Irish/Canada | Korean/Korea |
Haplotype analysis | Common founder (Finnish) | Common founder (Finnish) | Independent founder | Not analyzed yet |
Family history of PD | Yes | Yes | Yes | Yes |
Age-at-onset (yr) | 32, 36, 62 | 25, 42 | 25, 37, 58 | 55 |
Levodopa responsiveness | Yes | Yes | Yes | Yes |
Dyskinesia | Not available | Yes | Yes | Yes (mild) |
Cognitive impairment | Not available | Not available | Yes | Yes |
Psychiatric disturbances | Insomnia, anxiety, panic | Panic, depression | Psychosis | Psychosis, anxiety, depression |
Myoclonus | Yes | Not available | Yes | No |
Clinical diagnosis | Atypical PD | IPD | MSA | IPD/PDD early converter |
Neuropathology | LB pathology & GCI in oligodendrocyte pTDP-43(+), p62(+), tau(+) | Not available | Not available | Not available |
Comments on this article
Pasanen et al., [5] 2014 | Martikainen et al., [8] 2015 | Picillo et al., [7] 2018 | Our case | |
---|---|---|---|---|
Ethnicity/nation | Finnish/Finland | Finnish/Finland | Mixed Dutch, Scottish, and Irish/Canada | Korean/Korea |
Haplotype analysis | Common founder (Finnish) | Common founder (Finnish) | Independent founder | Not analyzed yet |
Family history of PD | Yes | Yes | Yes | Yes |
Age-at-onset (yr) | 32, 36, 62 | 25, 42 | 25, 37, 58 | 55 |
Levodopa responsiveness | Yes | Yes | Yes | Yes |
Dyskinesia | Not available | Yes | Yes | Yes (mild) |
Cognitive impairment | Not available | Not available | Yes | Yes |
Psychiatric disturbances | Insomnia, anxiety, panic | Panic, depression | Psychosis | Psychosis, anxiety, depression |
Myoclonus | Yes | Not available | Yes | No |
Clinical diagnosis | Atypical PD | IPD | MSA | IPD/PDD early converter |
Neuropathology | LB pathology & GCI in oligodendrocyte pTDP-43(+), p62(+), tau(+) | Not available | Not available | Not available |
PD, Parkinson’s disease; LB, Lewy body; GCI, glial cytoplasmic inclusion; IPD, idiopathic Parkinson’s disease; MSA, multiple system atrophy; PDD, Parkinson’s disease dementia.