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JMD > Epub ahead of print
   [Epub ahead of print]
Evidence of Inflammation in Parkinson’s Disease and Its Contribution to Synucleinopathy
Thuy Thi Lai1,2, Yun Joong Kim3, Hyeo-il Ma1,2, Young Eun Kim1,2
1Department of Neurology, Hallym University Sacred Heart Hospital, Hallym University, Anyang, Korea
2Hallym Neurological Institute, Hallym University, Korea
3Department of Neurology, Yonsei University College of Medicine, Yongin, Korea
Corresponding Author: Young Eun Kim ,Email: yekneurology@hallym.or.kr
Received: June 5, 2021;   Revised: July 12, 2021;   Accepted: August 4, 2021.
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ABSTRACT
Accumulation of alpha-synuclein (αSyn) protein in neurons is a renowned pathological hallmark of Parkinson’s disease (PD). In addition, accumulating evidence indicates that activated inflammatory responses are involved in the pathogenesis of PD. Thus, achieving a better understanding of the interaction between inflammation and synucleinopathy in relation to the PD process will facilitate the development of promising disease-modifying therapies. In this review, the evidence of inflammation in PD is discussed, and human, animal, and laboratory studies relevant to the relationship between inflammation and αSyn are explored as well as new therapeutic targets associated with this relationship.
Key Words: Alpha-synuclein; Astrocyte; Inflammation; Lymphocyte; Microglia; Parkinson’s disease
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