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Original Article
Clinical Milestones Preceding the Diagnosis of Multiple System Atrophy and Progressive Supranuclear Palsy: A Retrospective Cohort Study
Louise Wiblin1orcid, Rory Durcan2, Brook Galna2, Mark Lee3, David Burn2
Journal of Movement Disorders 2019;12(3):177-183.
Published online: August 9, 2019

1Department of Neurosciences, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK

2Institute of Neuroscience, Newcastle University, Newcastle-upon-Tyne, UK

3St. Benedict’s Hospice, Sunderland, UK

Corresponding author: Louise Wiblin, MRCP, MD Department of Neurosciences, Royal Victoria Infirmary, Queen Victoria Rd, Newcastle-upon-Tyne NE1 4LP, UK / Tel: +44-0191-233-6161 / E-mail:
• Received: January 30, 2019   • Revised: April 1, 2019   • Accepted: April 29, 2019

Copyright © 2019 The Korean Movement Disorder Society

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • Objective
    Multiple System Atrophy (MSA) and progressive supranuclear palsy (PSP) are rapidly progressive forms of degenerative Parkinsonism. The difficulties of diagnosing MSA and PSP in their early stages may lead to delayed referral to appropriate specialists and distress to patients, as well as delaying symptomatic treatment and participation in clinical trials. This work aimed to describe the symptoms that patients with MSA and PSP developed and plot their emergence relative to final diagnosis using a median onset in months.
  • Methods
    Forty-seven patients from the United Kingdom with MSA or PSP diagnosed by a movement disorder specialist were interviewed with carers or relatives to establish milestone onset. This was corroborated using clinical notes and letters.
  • Results
    In the MSA cohort (n = 23), autonomic symptoms (median 5.5 months before diagnosis) and falls (median 1 month before diagnosis) were the two clinical milestones which occurred before diagnosis. In the PSP cohort (n = 24), falling was the only milestone which occurred before diagnosis (median of 18.5 months).
  • Conclusion
    This Study Shows That Psp Patients Experience Falling More Than A Year And A Half An Average Before Receiving A Diagnosis And Although Msa Patients Also Tended To Fall, This Was Much Closer To The Time Of Diagnosis. Further Work With Larger Cohorts May Illustrate Whether These Preliminary Findings Can Be Generalised To Guide Diagnosis And Management.
Multiple System Atrophy (MSA) and progressive supranuclear palsy (PSP) are sporadic, atypical parkinsonian disorders. Patients with these disorders have an aggressive course, respond more poorly to dopaminergic therapy and have a reduced survival compared with patients with Parkinson’s disease (PD) [1,2]. MSA is characterized by predominant Parkinsonism (MSA-P) or cerebellar signs (MSA-C) with autonomic dysfunction. It has a mean survival time of between 6 and 10 years, and the subtype does not appear to affect survival [3]. PSP was, until recently, defined as the presence of a supranuclear gaze palsy or slow vertical saccades and postural instability with falls within the first year of onset [National Institute of Neurological Disorders and Stroke and the Society for PSP (NINDS-SPSP) criteria]. Two subtypes were described: Richardson’s syndrome with prominent axial rigidity, postural instability and ocular motor dysfunction and a parkinsonian form, PD-like in the early stages but with features of falls, poor levodopa response and eye movement problems emerging later [1,4]. More recently (after these data were collected), Movement Disorder Society-Progressive Supranuclear Palsy criteria have been proposed that comprise four key features (ocular motor function, cognitive function, postural instability and akinesia) [5]. The mean survival of PSP is 7.1 years from onset according to one study in a southern Italian population [6], with a recent meta-analysis in 2017 suggesting a median survival of between 5.3 and 10.2 years from symptom onset [7].
The process of reaching a diagnosis of MSA or PSP can be protracted. This is in part due to possible similarities in the early stages of disease to more common conditions such as PD. These conditions can be heterogeneous in appearance, with a varied constellation of symptoms resulting in referrals to other specialties (such as ophthalmology in PSP and urology in MSA) first. In some cases, diagnosis is only reached after postmortem examination [7,8]. It is therefore helpful to consider whether certain symptoms may precede others from the patient’s point of view. The patient’s account and that of their relatives may provide a clinical history that enables appropriate referral and facilitates a timelier diagnosis.
Although the progression and trajectory of each patient’s disease will be individual, a better understanding of the evolution of symptoms, the order in which they arise and their time of onset would be valuable for clinical decision-making and advance care planning (ACP). For instance, swallowing dysfunction may trigger a discussion about whether the patient would accept percutaneous endoscopic gastrostomy (PEG) feeding, if appropriate. Accumulating speech problems might add urgency to future planning (as might accumulating cognitive decline) so that patients can make the most informed decisions possible and have the opportunity to communicate their wishes, with the support of their relatives.
This retrospective study aimed to describe the onset of key symptoms in MSA and PSP in relation to their diagnosis, which may help delineate the symptoms of disease that patients and carers become aware of early on and when particular milestones tend to manifest relative to diagnosis.
Patient recruitment and inclusion
Forty-seven patients were recruited from the north-east of England, 23 with a diagnosis of MSA and 24 with PSP. All patients were diagnosed by a neurologist specializing in movement disorders and fulfilled the Second Consensus Criteria for the diagnosis of MSA or the NINDS-SPSP criteria for PSP where appropriate [9,10]. The Höglinger Criteria for PSP was released after the close of the study but was imposed afterwards for consistency to check the accuracy of diagnosis, as the Höglinger Criteria are more sensitive and specific for progressive supranuclear palsy-Parkinsonism (PSP-P) and other forms such as pure akinesia with gait freezing (PAGF) (Table 1 and 2) [5]. The study aimed to recruit a minimum of 20 patients with MSA and 20 with PSP as part of a wider study looking at the trajectory of diagnosis, symptom onset and a number of other variables such as quality of life. There was no upper limit for recruitment. Sample size was determined on the basis of obtaining meaningful pilot data and the population of patients within the geographical region [11]. Patients were approached by their neurologist within the movement disorder clinic in Newcastle, Sunderland or Middlesbrough in the UK, which were participant recruitment centers. It was made explicit to all patients that electing not to take part would have no impact upon their clinical care.
Data collection
Ten key clinical milestones were selected after a review of the literature (Table 3 and 4) [1]. These were the onset of falls, autonomic dysfunction (here defined as orthostatic hypotension and urinary dysfunction), the need for a wheelchair, speech problems, swallowing difficulty, acute admission as a consequence of atypical Parkinsonism, catheterization, PEG insertion, tracheostomy and admission to a care facility. These milestones were selected on the basis of clinical utility. They reflect important markers of disease progression, tend to be noticeable when they occur, are readily recalled by the patient or carer, and thus are more likely to be documented in medical notes or clinical letters. These milestones were defined using the same wording and definitions for consistency between participants (e.g., definition of dysarthria was ‘the point at which it was felt that you were difficult to understand by others’). The median time to onset for each milestone within the MSA and PSP groups was calculated relative to the time of diagnosis.
If a participant reached a milestone that was attributable to another established condition or cause, they were excluded from the analysis of that clinical milestone only. This was the case for one participant with MSA who received a catheter following surgery for prostate cancer 26 years prior to the interview and a participant with PSP who used a wheelchair due to a spinal injury incurred 11 years before the diagnosis of PSP.
Milestone-onset was corroborated by the carer/relative, medical notes and clinical letters. All participants’ interviews were cross-checked with their notes and clinical letters, and all but one patient in the PSP group had a carer to corroborate patient accounts (this carer planned to attend the research facility but failed to do so). The onset of each milestone was recorded in months and compared with the date of diagnosis with MSA or PSP (for consistency, the time of diagnosis was defined as the revised diagnosis of MSA or PSP rather than an earlier misdiagnosis of PD, for example).
Statistical analysis was carried out with IBM SPSS version 23 (IBM Corp., Armonk, NY, USA). Milestones, such as speech problems, were reviewed and plotted on graphs to visually represent their onset relative to diagnosis (‘-’ numbers signifying before diagnosis and ‘+’ after) Each milestone was then analyzed within disease groups for its median-onset relative to the point of diagnosis. These values were then plotted to determine the temporal sequence of onset compared to other milestones and the time of diagnosis (Figure 1 and 2). Median scores were used to describe these onset times as their distributions were not normal on visual inspection of histograms and on the basis of the results of Shapiro-Wilk tests.
Ethical statement
All procedures performed in studies involving human participants were conducted in accordance with the ethical standards of Newcastle University and the Humber-Leeds/Bradford branch of the UK Ethics Committee. These assess the compliance of studies with the 1975 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all the patients included in the study. Permissions were given by Yorkshire and the Humber-Leeds/Bradford Regional Ethics Committee (REC), study number 15/YH/0459.
Of the 47 patients, 23 had received a prior diagnosis before it was revised to MSA or PSP. In the MSA group, 11 out of 23 had a prior diagnosis (10 MSA-P, 1 MSA-C), all of which were PD. The median time to the revision of the diagnosis was 41 months. In the PSP group, 12 out of 24 had a prior diagnosis. Nine patients were originally diagnosed with PD, 7 of which were later revised to PSP-P. The remaining 2 were rediagnosed as having progressive supranuclear palsy-Richardson’s syndrome (PSPRS). Three patients received prior diagnoses other than PD: frontotemporal dementia, ‘mixed dementia’ and ‘stroke disease’ These latter three patients were all rediagnosed as having PSPRS; however, it should be noted that in those cases, the original diagnoses were not made by a neurologist or movement disorder specialist. The median time to rediagnosis in the PSP group was also a median of 41 months.
Of the 23 MSA patients, 11 were male and 12 were female. The mean age for patients with MSA was 64.6 years (SD 10.1), and the median disease duration was 33 months (IQR: 29 months, range 5–105 months). Sixteen patients had MSA-P, and 7 had MSA-C. Using the Second Consensus Criteria, 17 patients had probable MSA, and 6 had possible MSA [9].
Of the 24 patients with PSP, 10 were female and 14 were male. The mean age was 71.6 years (SD 6.8), and the median disease duration was 25.5 months (IQR 30.8, range 9–215 months). Of the 24 patients with PSP, 13 had PSP-RS, 10 had PSP-P and one had PSP-PAGF. Using the NINDS-SPSP Criteria in use at the time of the study, 16 patients had probable PSP, and 7 had possible PSP [the remaining patient had progressive supranuclear palsy-progressive akinesia with gait freezing (PSP-PAGF), which is not well identified using the NINDS criteria]. After the release of the Höglinger Criteria, the examination findings were compared: 19 had probable PSP and 5 had possible PSP. The improvement is likely due to the better detection of subtypes such as PSP-P and PAGF using these new criteria.
Overall, the most prevalent milestones in MSA were autonomic symptoms (20/23, 87%), speech disturbance (21/23, 91%) and falls (19/23, 83%). Three patients (13%) denied autonomic symptoms; however, one patient had well-documented erectile dysfunction and urinary incontinence, although during the research consultation, they declined to discuss or acknowledge this, likely due to embarrassment. The remaining two patients had objective abnormalities on autonomic function tests though they denied experiencing any subjective symptoms. Therefore, all MSA participants had autonomic dysfunction. Meanwhile, among the patients with PSP, the most prevalent milestones were falls (22/24, 92%), speech disturbance (18/24, 75%) and acute admissions (13/24, 54%).
The most frequently occurring first milestones in patients with MSA were falls and autonomic dysfunction, with 10 patients reporting falls as their first milestone and 10 patients reporting autonomic symptoms as their first milestone (10/23, 43%); one patient had falls and autonomic symptoms with simultaneous onset as a joint first milestone. Speech disturbance was the first reported milestone in five patients in the MSA group (in one case reported at the same time as autonomic symptoms and in another at the same time as falls), while three PSP patients reported speech disturbance as their first (or joint first) milestone. Overall, the prevalence of speech disturbance was high among both the MSA (91.3%) and PSP groups (75%). The predominant first milestone in patients with PSP was falling: 19 of the 24 (79%) patients had falling as their first clinical milestone. Two patients reported speech disturbance as the first symptom noted, and 1 patient had speech disturbance and falls with onset at the same time (13%).
The milestones with a median time of onset preceding a diagnosis of MSA were autonomic symptoms [median onset -5.5 months (range -79 to 33 months), IQR 55.5] and falls [-1 month (range -93 to 34 months), IQR 30.0].
In patients with PSP, only falls had a median time of onset preceding a diagnosis, at -18.5 months [(range -145 to 4 months), IQR 49.8]. Need for a wheelchair occurred at a median of 12 months (range 2 to 113 months, IQR 50.3) after diagnosis in patients with MSA and 16 months (range 1 to 132 months, IQR 20.5) in patients with PSP (Figure 1 and 2).
In terms of falling, when patients with MSA were split into subgroups, the MSA-P group fell a median of 3 months after diagnosis, whereas the MSA-C group fell a median of 19 months prior to diagnosis. There were no significant differences between the subtypes according to the Mann-Whitney U test (p = 0.097). The reason for this may be greater unsteadiness in the MSA-C group due to added ataxia combined with autonomic dysfunction. However, it is possible that the MSA-C group was diagnosed later after the onset of symptoms because the cerebellar form of MSA is less common in European populations, therefore experiencing a comparatively greater lag in reaching a movement disorder specialist [12].
When the PSP group was divided into subtypes, the PSP-RS group fell a median of 36 months prior to diagnosis, whereas the PSP-P group fell a median of 7 months prior to diagnosis. There was no significant difference between the groups according to the Mann-Whitney U test (p = 0.071), which may be due to the small sample size. An earlier onset of falling in the RS subgroup of PSP would be expected from previous work suggesting a more rapid decline in the RS subtype [13].
The time difference between the onset of the first milestone and diagnosis was compared using Mood’s Median test between the two disease groups, and there were no significant differences. Furthermore, there were no differences overall in the time difference from the onset of the first milestone to diagnosis among the three groups; with autonomic dysfunction as the first milestone, speech as the first milestone, and falls as the first milestone, according to Kruskal Wallis tests.
This pilot study has some important implications, both for research purposes and in terms of clinical considerations. The ability to predict the disease type more accurately in the prediagnostic phase may have implications for earlier diagnosis, effective referral (which also helps patient uncertainty, a known burden), palliative care and ACP [14]. Identifying patient cohorts in the early stages of disease who are eligible for novel drug trials is also increasingly important. In this discussion, the findings of the study are considered in light of the possible implications and the work that needs to be done in the future.
The first milestone perceived by MSA patients in this cohort before diagnosis was autonomic dysfunction, specifically orthostatic hypotension and urinary symptoms, with a median onset of 5.5 months prior to diagnosis. Falls were the only other milestone that had a median onset prior to diagnosis (1 month). Speech problems, autonomic symptoms and then falling were the most common milestones reached overall. In the PSP group, falls were the only milestone with a median onset prior to diagnosis at -18.5 months. In the PSP group, the three milestones with the highest overall incidence were falls, speech dysfunction and acute admissions, largely due to injuries sustained during falling.
What are the ramifications of these findings and how might they relate to the issues surrounding MSA and PSP in practice? One of the current challenges posed by MSA and PSP is accurately diagnosis in the early stages; this encompasses not only the specialist differentiating between types of atypical parkinsonism but also general practitioners being able to identify patients needing a referral to a movement disorder specialist. It is these generalists who see the patients in the prediagnostic phase, and knowing which symptoms patients become aware of early on may allow us to guide generalists to refer these patients appropriately for a more rapid diagnosis.
This pilot work also describes the onset of certain symptoms, such as dysphagia and speech difficulty, relative to the time of diagnosis. Having an idea of average disease trajectories is valuable to the clinician caring for these patients and their families. It can allow frank discussions and planning, incorporating ACP. Many patients wish to know how their disease will progress, and when they might expect particular issues to occur, such as loss of mobility. This can have implications for whether they can remain at home and which adaptations may be required to permit this.
In addition to practical planning, a key part of caring for patients with neurodegenerative conditions such as MSA and PSP is discussing issues such as resuscitation and which treatments would be acceptable to patients while they are still able to communicate intelligibly. Having a guide as to when this may become problematic for the patient is helpful.
Although this is a small sample population, and the clinical milestones were determined largely from retrospective history (albeit with corroboration from clinical notes and letters when possible), the onset of memorable symptoms and how they relate to the time of diagnosis is clinically useful. For example, if a patient with atypical parkinsonism (type not yet clear) has sustained falls for a year or more (not clearly related to hypotension), then according to the results of this study, it might be inferred that the patient will subsequently be diagnosed with PSP. The subjective perspective of patients and carers may also be helpful, as individuals often detect problems with normal functioning before they are ascribed to a unifying problem by clinicians.
The limitations of this work are the small sample size, possibilities of recall bias on the part of participants, especially if reliable clinical documentation dating certain milestones was absent, and the cross-sectional nature of the study. Unfortunately, contemporaneous data collection of symptoms and signs prior to a rare diagnosis are unlikely, as population studies would not contain enough subjects likely to develop PSP or MSA. Large longitudinal studies are being conducted, but symptoms occurring before a diagnosis is made must be determined retrospectively. All participants were under the care of a specialist movement disorder neurologist, which adds bias; undiagnosed patients with MSA and PSP or patients who may be receiving care from nonspecialists and have not been referred to the movement disorder specialist services may well have a longer lag time to diagnosis, but these patients could not be easily identified within the limitations of the recruitment process. Patients were diagnosed according to the recommended criteria, but the gold standard of diagnosis in these conditions is an autopsy postmortem, which was beyond the scope of this study. Although the range of disease duration was large, the median disease duration was fairly short. The strengths of this study are its inclusiveness, the use of multiple sources to try and verify the timing of symptoms and the presentation of symptom trajectories relative to the point at which the patient was diagnosed; this study was a pragmatic attempt to delineate what patients experience before they achieve a diagnosis of atypical parkinsonism and how we may use this knowledge in the future to diagnose these patients earlier.
There are large cohorts with MSA and PSP in observational studies, such as the PROgressive Supranuclear Palsy CorTico-Basal Syndrome Multiple System Atrophy Longitudinal Study UK (PROSPECT) study being conducted in the UK, which are exploring prediagnostic symptoms and will also follow patients over a number of years to produce a trajectory of disease progression [15]. Larger studies such as these may verify our findings of falls as a key prediagnostic symptom, with falls in PSP occurring more distantly from the time of diagnosis to MSA.
This is a small pilot study that has shown that in a cohort of 47 patients with atypical parkinsonism, the MSA group of 23 patients had two key symptom milestones that arose before diagnosis: falls (1 month before) and autonomic symptoms (5.5 months before). In the PSP group (24 patients), only one milestone on average predated diagnosis, namely, falls, which occurred an average of 18.5 months before diagnosis.
There may be a significant finding here that could be helpful in discriminating between MSA and PSP in the early phase of disease. This is important not only for addressing patient uncertainty and clinical planning for the future but also in selecting patients with early disease for trials and eventually, potentially disease-modifying treatments, as research continues to seek agents that are neuroprotective or interfere with disease progression.

Conflicts of Interest

None of the authors have any financial disclosures to disclose related to this work. Louise Wiblin, Rory Durcan and David Burn were involved in patient recruitment and data collection for the PROSPECT study cited in the references, although this study is not connected to that work. Otherwise, there are no declarations of conflicts of interest.

Figure 1.
Schematic drawing showing the onset of clinical milestones relative to the diagnosis of Multiple System Atrophy (MSA). Each individual’s onset is represented by a circle.
Figure 2.
Schematic drawing showing the onset of clinical milestones relative to the diagnosis of progressive supranuclear palsy (PSP). Each individual’s onset is represented by a circle.
Table 1.
Characteristics of MSA cohort including demographics, probability of diagnosis using Second Consensus Criteria, disease and follow-up duration (in months)
Characteristics of the MSA group
Number 23
Sex (female) 12
Age (years) 64.6 (SD 10.1)
 MSA-P 16
 MSA-C 7
Second Consensus Criteria
 Probable 17
 Possible 6
Median duration of disease (months) 33.0 (IQR 29.0)
 MSA-P 29.0 (IQR 28.8)
 MSA-C 34.0 (IQR 59.0)
Median duration of follow-up (months) 53.0 (IQR 21.0)
 MSA-P 51.0 (IQR 19.3)
 MSA-C 55.0 (IQR 60.0)

MSA: Multiple System Atrophy, MSA-P: predominant Parkinsonism, MSA-C: cerebellar signs, IQR: interquartile range.

Table 2.
Characteristics of PSP cohort including demographics, probability of diagnosis using NINDS-SPSP, disease and follow-up duration (in months)
Characteristics of the PSP group
Number 24
Sex (female) 14
Age (years) 71.6 (SD 6.8)
Subtype (n)
 PSP-RS 13
 PSP-P 10
NINDS-SPSP (1996) [10]/Höglinger (2017) [5] (n)
 Probable 16/19
 Possible 7/5
Median duration of disease (months) 25.5 (IQR 30.8) overall
 PSP-RS 21.0 (IQR 53.0)
 PSP-P 34.0 (IQR 59.0)
 PSP-PAGF 51.0 (IQR -)
Median duration of follow-up (months) 51.0 (IQR 37.0)
 PSP-RS 49 (IQR 49.5)
 PSP-P 56.5 (IQR 48.8)

PSP: progressive supranuclear palsy, NINDS-SPSP: National Institute of Neurological Disorders and Stroke and the Society for PSP criteria, IQR: interquartile range, PSP-RS: progressive supranuclear palsy-Richardson’s syndrome, PSP-P: progressive supranuclear palsy-Parkinsonism, PSP-PAGF: progressive supranuclear palsy-progressive akinesia with gait freezing.

Table 3.
Details of the incidence of clinical milestones, whether the onset preceded diagnosis and the median onset of symptoms relative to diagnosis of Multiple System Atrophy
Milestone Milestone present (n) Onset prior to diagnosis (n) Median onset before and after diagnosis (months)
Falls 18 11 -1
Autonomic 20 11 -5.5
Speech 21 7 10
Acute admissions 11 4 4
Catheter 8 2 21
Wheelchair 12 2 14.5
Swallowing 7 0 23
Institutionalization 3 0 46
PEG insertion 0 (2 pending) - -
Tracheostomy 0 - -

PEG: percutaneous endoscopic gastrostomy.

Table 4.
Details of the incidence of clinical milestones, whether the onset preceded diagnosis and the median onset of symptoms relative to diagnosis of progressive supranuclear palsy
Milestone Milestone present (n) Onset prior to diagnosis (n) Median onset before and after diagnosis (months)
Falls 22 18 -18.5
Speech 18 8 4
Acute admissions 13 6 0
Wheelchair 13 2 16
Swallowing 12 1 12.5
Autonomic 2 1 -
Catheter 4 0 31
Tracheostomy 0 - -
Institutionalization 1 0 -
PEG insertion 0 - -

PEG: percutaneous endoscopic gastrostomy.

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