KMDS
E-submission
Search
- Page Path
- HOME > Search
Review Article
- MRI-Guided Focused Ultrasound in Parkinson’s Disease and Essential Tremor: Incisionless but Invasive. A Narrative Review
- Vinod Metta, Hani Taha Sherif Benamer, Georgios Kapsas, Rukmini Mridula, Rajesh Alugolu, Hasna Hussain, Afsal Nalarakettil, Sampath Kumar Natuva Sai, Mohamed Elmahdy, Rupam Borgohain, Kallol Ray Chaudhuri
- J Mov Disord. 2025;18(4):289-303. Published online June 4, 2025
- DOI: https://doi.org/10.14802/jmd.25042
- 3,324 View
- 334 Download
- 1 Web of Science
- 1 Crossref
-
Abstract
PDF - Magnetic resonance-guided focused ultrasound (MRgFUS) is an emerging and promising technology for treating movement disorders, such as essential tremors and tremor-dominant Parkinson’s disease. MRgFUS utilizes advanced ultrasound transducer emitters to condense sound waves at a precisely defined point. This technology can target various brain areas, such as the pallidothalamic tract, thalamus, and pallidum, to ameliorate some of the symptoms of Parkinson’s disease and other movement disorders, such as dystonic and action-induced tremors. We review the current status of preclinical and clinical trials on the clinical use, treatment outcomes, and indications of MRgFUS.
-
Citations
Citations to this article as recorded by
- Tremor: Clinical Frameworks, Network Dysfunction and Therapeutics
Emmanuel Ortega-Robles, Oscar Arias-Carrión
Brain Sciences.2025; 15(8): 799. CrossRef
- Tremor: Clinical Frameworks, Network Dysfunction and Therapeutics
Brief communication
- Modified Ratio of Tremor/Postural Instability Gait Difficulty Score as an Indicator of Short-Term Outcomes of Subthalamic Nucleus Deep Brain Stimulation in Parkinson’s Disease
- Chakradhar Reddy, Kanchana Pillai, Shejoy Joshua, Anup Nair, Harshad Chavotiya, Manas Chacko, Asha Kishore
- J Mov Disord. 2025;18(2):165-169. Published online January 2, 2025
- DOI: https://doi.org/10.14802/jmd.24175
- 2,209 View
- 65 Download
-
Abstract
PDF
Supplementary Material - Objective
The outcomes of motor and nonmotor features of Parkinson’s disease (PD) following deep brain stimulation (DBS) vary among its subtypes. We tested whether preoperative motor subtyping using the modified tremor/postural instability and gait difficulty ratio (T/P ratio) could indicate the short-term motor, nonmotor and quality of life (QOL) outcomes of subthalamic nucleus (STN) DBS.
Methods
In this prospective study, 39 consecutive STN DBS patients were assessed in the drug-OFF state before surgery and subtyped according to the T/P ratio. Patients were reassessed 6 months after surgery in the stimulation ON-drug-OFF state, and the percentage changes in motor, nonmotor and QOL scores (Parkinson’s Disease Quality of Life Questionnaire [PDQ-39]) were calculated.
Results
The modified T/P ratio was moderately and positively correlated with the percentage change in the Unified Parkinson’s Disease Rating Scale III score in the OFF state, the sum of cardinal motor signs, the Non-Motor Symptom Scale score, and QOL (PDQ-39).
Conclusion
Preoperative PD motor subtyping can be used as an indicator of the short-term outcomes of STN DBS in PD patients.
Original Articles
- Polysomnographic Evaluation of Sleep Disorders in Essential Tremor and Essential Tremor Plus: A Comparison With Healthy Controls
- Ravi Prakash Singh, Mythirayee S, Doniparthi Venkata Seshagiri, Gulshan Kumar, Rohan Mohale, Pramod Kumar Pal, Bindu M Kutty, Jitender Saini, Nitish L Kamble, Vikram Holla, Ravi Yadav
- J Mov Disord. 2025;18(1):45-54. Published online October 28, 2024
- DOI: https://doi.org/10.14802/jmd.24191
- 4,827 View
- 130 Download
-
Abstract
PDF
- Objective
To explore sleep patterns in individuals with essential tremor (ET) and essential tremor plus (ET-Plus) compared with healthy controls and assess differences between ET and ET-Plus, given the lack of established polysomnography (PSG) data on these groups and the potential for sleep disturbances to serve as clinical markers.
Methods
We conducted a prospective cross-sectional study at National Institute of Mental Health and Neurosciences, Bengaluru, from November 2021 to August 2023 on 45 patients (26 ET, 19 ET-Plus) and 45 controls. Tremor severity was assessed using The Essential Tremor Rating Assessment Scale (TETRAS) and Fahn‐Tolosa‐Marin Clinical Rating Scale (FTMRS). Sleep symptoms were assessed via the Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, Mayo Sleep Questionnaire, restless legs syndrome questionnaire, Berlin questionnaire, Generalized Anxiety Disorder Scale 7, and Patient Health Questionnaire-9. All patients and controls underwent overnight video PSG. Sleep scoring was manually performed by a trained sleep research technician and the first author following the American Academy of Sleep Medicine (2017) guidelines, with data analyzed using R studio.
Results
Compared with ET-Plus patients, ET patients had a younger onset age (46.8±11.1 years versus 30.8±16.7 years, respectively). Compared with ET patients, ET-Plus patients had higher TETRAS and FTMRS scores (p<0.005). Compared with controls, both ET patients and ET-Plus patients presented poorer sleep quality, excessive daytime sleepiness, rapid eye movement (REM) sleep behavior disorder, and restless legs syndrome symptoms. PSG findings supported these clinical observations, showing an elevated apnea‒hypopnea index, reduced total sleep time, prolonged REM latency, decreased sleep efficiency, increased N1 stage duration, and reduced N2/N3 durations and percentages in patients versus controls.
Conclusion
The study highlights significant sleep architecture abnormalities in both ET and ET-Plus patients compared with healthy controls, with no differences between the ET groups.
- Analysis of Semiology, Lesion Topography and Treatment Outcomes: A Prospective Study on Post Thalamic Stroke Holmes Tremor
- Amlan Kusum Datta, Adreesh Mukherjee, Sudeshna Malakar, Atanu Biswas
- J Mov Disord. 2024;17(1):71-81. Published online October 20, 2023
- DOI: https://doi.org/10.14802/jmd.23095
- 5,765 View
- 508 Download
- 1 Web of Science
- 1 Crossref
-
Abstract
PDFSupplementary Material
- Objective
Holmes tremor (HT) comprises rest, postural and intention tremor subtypes, usually involving both proximal and distal musculature. Perturbations of nigro-striatal pathways might be fundamental in the pathogenesis of HT along with cerebello-thalamic connections.
Methods
Nine patients with an HT phenotype secondary to thalamic stroke were included. Epidemiological and clinical records were obtained. Structural and functional brain imaging were performed with magnetic resonance imaging (MRI) or computed tomography (CT) and positron emission tomography (PET), respectively. Levodopa was administered in sequentially increasing dosage, with various other drugs in case of inadequate response. Longitudinal follow-up was performed for at least three months. The essential tremor rating assessment scale (TETRAS) was used for assessment.
Results
The mean latency from stroke to tremor onset was 50.4 ± 30.60 days (range 21–90 days). Dystonia was the most frequently associated hyperkinetic movement (88.8%). Tremor was bilateral in 22.2% of participants. Clinical response was judged based on a reduction in the TETRAS score by a prefixed value (≥ 30%), pertaining to which 55.5% (n = 5) of subjects were classified as responders and the rest as non-responders. The responders showed improvement with significantly lower doses of levodopa than the remaining nonresponders (240 ± 54.7 mg vs. 400 ± 40.8 mg; p = 0.012).
Conclusion
Although levodopa is useful in HT, augmenting the dosage of levodopa beyond a certain point might not benefit patients clinically. Topography of vascular lesions within the thalamus might additionally influence the phenomenology of HT. -
Citations
Citations to this article as recorded by- Holmes Tremor with Dystonia after Parietal and Premotor Ischemic Stroke in an Essential Tremor Patient: A Case Report
Luca Angelini, Rick C.G. Helmich
Movement Disorders Clinical Practice.2026;[Epub] CrossRef
- Holmes Tremor with Dystonia after Parietal and Premotor Ischemic Stroke in an Essential Tremor Patient: A Case Report
Review Articles
- Adult-Onset Genetic Leukoencephalopathies With Movement Disorders
- Mu-Hui Fu, Yung-Yee Chang
- J Mov Disord. 2023;16(2):115-132. Published online March 7, 2023
- DOI: https://doi.org/10.14802/jmd.22127
-
Abstract
PDF
- Genetic leukoencephalopathies (GLEs) are a group of white matter abnormalities with heterogeneous radiological and phenotypic features. Although these conditions have mostly been described in children, adult-onset cases are increasingly recognized owing to the widespread use of neuroimaging and advances in molecular genetic testing. The disease course is often progressive with a varied spectrum of presentations, trapping neurologists in the dilemma of differential diagnosis. Movement disorders are among the most common symptoms, and their diversity makes diagnosis challenging. In this review, we focus on adult-onset GLEs with movement disorders and offer a step-by-step diagnostic approach by clarifying the phenomenology of movement, advising investigations for acquired causes, describing the clinical and radiological clues to each disease, emphasizing the limitations of advanced molecular testing, and discussing the future application of artificial intelligence. We provide a list summarizing the leukoencephalopathies associated with different categories of movement disorders. In addition to guiding clinicians on how to narrow the list of differential diagnoses with the tools currently available, another aim of this review is to emphasize the inevitable trend toward applying advanced technology in diagnosing these difficult diseases.
-
Citations
Citations to this article as recorded by- A rare case of adult-onset vanishing white matter leukoencephalopathy with movement disorder, expressing homozygous EIF2B3 and PRKN pathogenic variants
Bashar Kamal Ali Douden, Yazan Mohammad Abdullah Abufara, Mahmood Fayez Ali Aldrabeeh, Naela Ramadan Mohammad Tell, Ismail Abudaya
BMC Neurology.2025;[Epub] CrossRef
- A rare case of adult-onset vanishing white matter leukoencephalopathy with movement disorder, expressing homozygous EIF2B3 and PRKN pathogenic variants
- Movement Disorders Associated With Radiotherapy and Surgical Procedures
- Bharath Kumar Surisetti, Shweta Prasad, Vikram Venkappayya Holla, Nitish Kamble, Ravi Yadav, Pramod Kumar Pal
- J Mov Disord. 2023;16(1):42-51. Published online January 12, 2023
- DOI: https://doi.org/10.14802/jmd.22092
- 8,281 View
- 224 Download
- 4 Web of Science
- 4 Crossref
-
Abstract
PDF
- Occasionally, movement disorders can occur following interventional procedures including but not limited to radiotherapy, dental procedures, and cardiac, cerebral and spinal surgeries. The majority of these disorders tend to be unexpected sequelae with variable phenomenology and latency, and they can often be far more disabling than the primary disease for which the procedure was performed. Owing to poor knowledge and awareness of the problem, delays in diagnosing the condition are common, as are misdiagnoses as functional movement disorders. This narrative review discusses the phenomenology, pathophysiology, and potential treatments of various movement disorders caused by interventional procedures such as radiotherapy and neurological and non-neurological surgeries and procedures.
-
Citations
Citations to this article as recorded by- Delayed Holm’s tremor complicated by contralateral midbrain metastasis: A nigrostriatal subtype
Sang-Won Yoo, Hyochun Lee, Joong-Seok Kim
Neurological Sciences.2025; 46(5): 2329. CrossRef - Cancer-related movement disorders: A scoping review and diagnostic approach
Laura E Schroeder, Ethan Snow, Casandra Chen, Amy Addo, Nahid Mohammadzadeh, Lawrence Recht, Saud Alhusaini
Neuro-Oncology Practice.2025; 12(6): 970. CrossRef - Myoclonus: an update
Betsy Thomas, Steven J. Frucht
Current Opinion in Neurology.2024; 37(4): 421. CrossRef - Biofeedback Endurance Training for Gait Rehabilitation in Parkinson’s Disease: a Non-Randomized Controlled Study
Olga V. Guseva, Natalia G. Zhukova
Bulletin of Rehabilitation Medicine.2023; 22(6): 21. CrossRef
- Delayed Holm’s tremor complicated by contralateral midbrain metastasis: A nigrostriatal subtype
Case Report
- Deep Brain Stimulation for Cockayne Syndrome-Associated Movement Disorder
- Joseph S. Domino, Rose Gelineau-Morel, Christian Kaufman
- J Mov Disord. 2022;15(1):62-65. Published online November 3, 2021
- DOI: https://doi.org/10.14802/jmd.21005
- 5,816 View
- 258 Download
- 2 Web of Science
- 3 Crossref
-
Abstract
PDFSupplementary Material
- Cockayne syndrome (CS) is a rare progeroid disorder characterized by multisystem degeneration, including neurological dysfunction, for which deep brain stimulation (DBS) is a proposed treatment. This study represents only the third case of DBS for CS-associated movement disorder and the first in which both proposed targets had devices implanted, allowing for direct comparison. A case of DBS for CS-associated movement disorder is presented. Previous literature documents two cases with one targeting the ventral intermediate nucleus of the thalamus (VIM) and the other targeting the globus pallidus interna (GPi). Our patient underwent stimulation of GPi nuclei followed by repositioning to VIM nuclei with improved symptom control using VIM stimulation. In all cases, there was a significant clinical benefit without off-target effects. CS-associated movement disorder exhibits phenotypic variability for which DBS is a viable treatment. Target selection should be driven by clinical phenotype.
-
Citations
Citations to this article as recorded by- Simultaneous, dual-target, bilateral deep brain stimulation for treatment of galactosemia-induced dystonia and tremor in a pediatric patient
Adip G. Bhargav, Paige A. Lundy, Keith A. Coffman, Christian B. Kaufman
Child's Nervous System.2025;[Epub] CrossRef - Cockayne syndrome type 3 with dystonia‐ataxia and clicking blinks
Özge Berna Gültekin‐Zaim, Gül Yalçın‐Çakmaklı, Ayşe İlksen Çolpak, Pelin Özlem Şimşek‐Kiper, Gülen Eda Utine, Bülent Elibol
Movement Disorders Clinical Practice.2023;[Epub] CrossRef - Hypomyelinating leukodystrophy and movement disorders
Jacky Ganguly, Jigyasha Sinha, Purba Basu, Anushree Pal, Banashree Mondal, Mona Tiwari, Hrishikesh Kumar
Annals of Movement Disorders.2023; 6(2): 58. CrossRef
- Simultaneous, dual-target, bilateral deep brain stimulation for treatment of galactosemia-induced dystonia and tremor in a pediatric patient
Brief communication
- Phonatory Characteristics of Male Patients with Classic Essential Tremor
- Preetie Shetty Akkunje, Belur Keshavaprasad Yamini, Ravi Yadav, Nagarajarao Shivashankar, Palash Kumar Malo, Kandavel Thennarasu, Shantala Hegde, Pramod Kumar Pal
- J Mov Disord. 2021;14(3):226-230. Published online August 18, 2021
- DOI: https://doi.org/10.14802/jmd.21010
- 6,775 View
- 109 Download
- 3 Web of Science
- 3 Crossref
-
Abstract
PDFSupplementary Material
- Objective
Voice tremor (VT) is one of the characteristics of essential tremor (ET). This study was designed to describe the group and phonatory characteristics of classic ET patients with VT.
Methods
This retrospective case-control study compared classic ET patients with age and sex-matched controls. The ET population was subgrouped based on auditory perceptual voice analysis. Electroglottography and acoustic voice samples obtained from both groups were analyzed for contact quotient (CQ) and multidimensional voice program parameters, i.e., fundamental frequency (F0), perturbation, noise, and tremor parameters.
Results
The CQ, F0, perturbation, noise, and tremor characteristics significantly increased from the moderate VT group to the severe VT group.
Conclusion
The CQ, F0, and noise characteristics reflected the vocal folds’ functionality. The perturbation and tremor parameters variation were reasoned considering the tremor-related changes occurring in the laryngeal, vocal tract, and expiratory muscles in patients with ET. Thus, phonatory analysis may help in monitoring the progression of ET. -
Citations
Citations to this article as recorded by- Voice Analysis in Patients with Essential Tremor
Hakan Silek, Muzeyyen Dogan
Journal of Voice.2025; 39(5): 1414.e9. CrossRef - Central auditory processing deficits in essential tremor
Preetie Shetty Akkunje, Belur Keshavaprasad Yamini, Ravi Yadav, Shantala Hegde, Aravind Kumar Rajasekaran, Pradeep Yuvaraj, Prashasti Prakash Poovaiah, Parthipulli Vasuki Prathyusha, Kandavel Thennarasu, Nagarajarao Shivashankar, Pramod Kumar Pal
Clinical Neurophysiology.2025; 176: 2110764. CrossRef - Exploiting speech tremors: machine learning for early diagnosis of amyotrophic lateral sclerosis
Ritu Chauhan, Urvashi Sharma
Engineering Research Express.2024; 6(4): 045224. CrossRef
- Voice Analysis in Patients with Essential Tremor
Case Report
- Involuntary Movements Following Administration of Hydroxychloroquine for COVID-19 Pneumonia
- Emmaline Zantua Fernando, Jeryl Ritzi Tan Yu, Salvador Miclat Abad Santos, Roland Dominic Go Jamora
- J Mov Disord. 2021;14(1):75-77. Published online December 7, 2020
- DOI: https://doi.org/10.14802/jmd.20091
- 8,125 View
- 126 Download
- 4 Web of Science
- 2 Crossref
-
Abstract
PDFSupplementary Material
- Hydroxychloroquine (HCQ) has been used as an investigational drug for patients with moderate to severe coronavirus disease 2019 (COVID-19). There have been concerns of potential harms from side effects of the drug. We present a case of a 38-year-old male who was started on HCQ for COVID-19 pneumonia. He was referred for evaluation of myoclonus of all extremities, which resolved after discontinuation of HCQ. The involuntary movements were first reported after the initiation of HCQ, persisted despite improvement in inflammatory and radiologic parameters and eventually resolved after HCQ discontinuation. This supports a possible causality related to adverse drug reactions from HCQ that have not been commonly reported.
-
Citations
Citations to this article as recorded by- Safety profile of COVID-19 drugs in a real clinical setting
Mei Nee Chiu, Maitry Bhardwaj, Sangeeta Pilkhwal Sah
European Journal of Clinical Pharmacology.2022; 78(5): 733. CrossRef - Eventos adversos no sistema nervoso central potencialmente relacionados aos medicamentos utilizados na COVID-19: revisão de escopo
Vinícius de Mello, Vinícius de Paula Pereira, João Paulo Vilela Rodrigues, Suelem Tavares da Silva Penteado, Leonardo Régis Leira Pereira, Fabiana Rossi Varallo
Revista Panamericana de Salud Pública.2022; 46: 1. CrossRef
- Safety profile of COVID-19 drugs in a real clinical setting
Review Article
- Principles of Electrophysiological Assessments for Movement Disorders
- Kai-Hsiang Stanley Chen, Robert Chen
- J Mov Disord. 2020;13(1):27-38. Published online January 31, 2020
- DOI: https://doi.org/10.14802/jmd.19064
- 25,173 View
- 2,034 Download
- 43 Web of Science
- 44 Crossref
-
Abstract
PDFSupplementary Material
- Electrophysiological studies can provide objective and quantifiable assessments of movement disorders. They are useful in the diagnosis of hyperkinetic movement disorders, particularly tremors and myoclonus. The most commonly used measures are surface electromyography (sEMG), electroencephalography (EEG) and accelerometry. Frequency and coherence analyses of sEMG signals may reveal the nature of tremors and the source of the tremors. The effects of voluntary tapping, ballistic movements and weighting of the limbs can help to distinguish between organic and functional tremors. The presence of Bereitschafts-potentials and beta-band desynchronization recorded by EEG before movement onset provide strong evidence for functional movement disorders. EMG burst durations, distributions and muscle recruitment orders may identify and classify myoclonus to cortical, subcortical or spinal origins and help in the diagnosis of functional myoclonus. Organic and functional cervical dystonia can potentially be distinguished by EMG power spectral analysis. Several reflex circuits, such as the long latency reflex, blink reflex and startle reflex, can be elicited with different types of external stimuli and are useful in the assessment of myoclonus, excessive startle and stiff person syndrome. However, limitations of the tests should be recognized, and the results should be interpreted together with clinical observations.
-
Citations
Citations to this article as recorded by- A review of treatment methods for movement disorders
Mahdi Khezri, Shakiba Afsar
Behavioural Brain Research.2026; 500: 115979. CrossRef - Central and peripheral excitability in restless limbs syndrome
Amedeo De Grado, Gaia Fanella, James Howells, Benjamin Yamin Ali Khan, Anna Bystrup Jacobsen, Bülent Cengiz, Gintaute Samusyte, Marit Otto, Paola Lanteri, Ambra Stefani, Hatice Tankisi
Brain Communications.2026;[Epub] CrossRef - Diagnostic Value of Bereitschaftspotential in People With Functional Seizures
Christoph S. Dietze, Dieke van Waart-Houtman, Anne Marthe Meppelink, Mireille Bourez-Swart, Job van der Palen, Maeike Zijlmans, Sandra M. A. van der Salm
Journal of Clinical Neurophysiology.2025; 42(4): 331. CrossRef - Diagnostic Utility of Clinical Neurophysiology in Jerky Movement Disorders: A Review from the MDS Clinical Neurophysiology Study Group
Anna Latorre, Christos Ganos, Masashi Hamada, Nicolas Phielipp, Lorenzo Rocchi, Shabbir Merchant, Marina A. Tijssen, Sterre van der Veen, Robert Chen
Movement Disorders Clinical Practice.2025; 12(3): 272. CrossRef - Utility and Value of Movement Recording with Combined EEG-EMG Monitoring in the Intensive Care Unit
Julie Lévi-Strauss, Clémence Marois, Yulia Worbe, Laurine Bedoucha, Raouf Benchikh Lehocine, Benjamin Rohaut, Nicolas Weiss, Sophie Demeret, Emmanuelle Apartis, Virginie Lambrecq
Neurocritical Care.2025; 43(1): 333. CrossRef - Application of surface electromyography in dentistry for diagnosis and treatment evaluation
So Ra Kim, Yeong-Gwan Im
Journal of Korean Dental Association.2025; 63(3): 64. CrossRef - Advances in sciatic nerve regeneration: A review of contemporary techniques
Sardar Ali, Ming Sun, Muhammad Nadeem Khan, Fang Qiang
Regenerative Therapy.2025; 29: 563. CrossRef - Surface‐electromyography characteristics of clonic seizures with no scalp‐EEG correlate: A comparative analysis with tremors
Veena V. Kumar, Akshaya R. Sivaji, Shwetank Singh, Zachary Scicchitano, Brandy Woods, Roohi Katyal, Neel Fotedar
Epileptic Disorders.2025; 27(4): 609. CrossRef - Impact of clinical neurophysiological assessment on diagnosis and management of tremor disorders
Katherine Longardner, Yasoda Satpathy, Irene Litvan, Dietrich Haubenberger
Clinical Neurophysiology Practice.2025; 10: 188. CrossRef - Hyperkinetic movement disorder analysis using multidimensional projections
Andressa Silva da Silva, Eduardo F. Ribeiro, Jelle R. Dalenberg, Alexandru C. Telea, Marina A.J. Tijssen, João Luiz Dihl Comba
Computers & Graphics.2025; 131: 104276. CrossRef - A Dynamic Current Pulsing Technique to Improve the Noise Efficiency Factor of Neural Recording Amplifiers
Yujia Huo, Roy H. Olsson
Journal of Low Power Electronics and Applications.2025; 15(4): 67. CrossRef - Surface electromyography for evaluating patients with oromandibular dystonia
Jae-Hyung Kim, Byung-Gook Kim, Yeong-Gwan Im
CRANIO®.2024; 42(3): 316. CrossRef - Clinical neurophysiology of functional motor disorders: IFCN Handbook Chapter
M.J. Edwards, L.H. Koens, J. Liepert, J. Nonnekes, P. Schwingenschuh, A.M.M. van de Stouwe, F. Morgante
Clinical Neurophysiology Practice.2024; 9: 69. CrossRef - Multimodal imaging and electrophysiological study in the differential diagnosis of rest tremor
Federica Aracri, Andrea Quattrone, Maria Giovanna Bianco, Alessia Sarica, Marida De Maria, Camilla Calomino, Marianna Crasà, Rita Nisticò, Jolanda Buonocore, Basilio Vescio, Maria Grazia Vaccaro, Aldo Quattrone
Frontiers in Neurology.2024;[Epub] CrossRef - Simple biomarkers to distinguish Parkinson’s disease from its mimics in clinical practice: a comprehensive review and future directions
Andrea Quattrone, Mario Zappia, Aldo Quattrone
Frontiers in Neurology.2024;[Epub] CrossRef - Substantiating the Short Burst Duration in Cortical Myoclonus
Sterre van der Veen, Amber Maliepaard, Madelein van der Stouwe, Jelle Dalenberg, Inge Tuitert, Jan Willem J. Elting, Marina A.J. Tijssen
Movement Disorders.2024; 39(12): 2275. CrossRef - Asterixis of peripheral origin: isolated lower limb asterixis in Guillain–Barre syndrome
Boby Varkey Maramattom
Acta Neurologica Belgica.2023; 123(3): 1095. CrossRef - Moving Beyond Movement: Diagnosing Functional Movement Disorder
Gabriela S. Gilmour, Sarah C. Lidstone
Seminars in Neurology.2023; 43(01): 106. CrossRef - Neurophysiology of Brain Networks Underlies Symptoms of Parkinson’s Disease: A Basis for Diagnosis and Management
Martha Teresa Acosta-Mejia, Nelson Villalobos
Diagnostics.2023; 13(14): 2394. CrossRef - Utility of Neurophysiological Evaluation in Movement Disorders Clinical Practice
Talyta Grippe, Robert Chen
Movement Disorders Clinical Practice.2023; 10(11): 1599. CrossRef - Development of a New Wearable Device for the Characterization of Hand Tremor
Basilio Vescio, Marida De Maria, Marianna Crasà, Rita Nisticò, Camilla Calomino, Federica Aracri, Aldo Quattrone, Andrea Quattrone
Bioengineering.2023; 10(9): 1025. CrossRef - Electrophysiology in Functional Movement Disorders: An Update
Nitish Kamble, Pramod Kumar Pal
Tremor and Other Hyperkinetic Movements.2023;[Epub] CrossRef - The clinical and electrophysiological investigation of tremor
Günther Deuschl, Jos S. Becktepe, Michiel Dirkx, Dietrich Haubenberger, Anhar Hassan, Rick C. Helmich, Muthuraman Muthuraman, Pattamon Panyakaew, Petra Schwingenschuh, Kirsten E. Zeuner, Rodger J. Elble
Clinical Neurophysiology.2022; 136: 93. CrossRef - Remote measurement and home monitoring of tremor
Zoltan Mari, Dietrich Haubenberger
Journal of the Neurological Sciences.2022; 435: 120201. CrossRef - Functional tremor
Petra Schwingenschuh, Alberto J. Espay
Journal of the Neurological Sciences.2022; 435: 120208. CrossRef - Speech-induced action myoclonus
Hugh D. Simpson, Joseph R. Duffy, Julie A.G. Stierwalt, J. Eric Ahlskog, Anhar Hassan
Parkinsonism & Related Disorders.2022; 98: 41. CrossRef - Simulation of the physical process of neural electromagnetic signal generation based on a simple but functional bionic Na+ channel
Fan Wang, Jingjing Xu, Yanbin Ge, Shengyong Xu, Yanjun Fu, Caiyu Shi, Jianming Xue
Chinese Physics B.2022; 31(6): 068701. CrossRef - Functional Patients Referred for Deep Brain Stimulation: How Common Is it?
Carolina Gorodetsky, Paula Azevedo, Alfonso Fasano
Movement Disorders Clinical Practice.2022; 9(6): 841. CrossRef - Myoclonus and other jerky movement disorders
Sterre van der Veen, John N. Caviness, Yasmine E.M. Dreissen, Christos Ganos, Abubaker Ibrahim, Johannes H.T.M. Koelman, Ambra Stefani, Marina A.J. Tijssen
Clinical Neurophysiology Practice.2022; 7: 285. CrossRef - Posthypoxic Segmental Spinal “Flutter”-Like Myoclonus
Boby V Maramattom
Neurology India.2022; 70(5): 2202. CrossRef - Contemporary clinical neurophysiology applications in dystonia
Petr Kaňovský, Raymond Rosales, Pavel Otruba, Martin Nevrlý, Lenka Hvizdošová, Robert Opavský, Michaela Kaiserová, Pavel Hok, Kateřina Menšíková, Petr Hluštík, Martin Bareš
Journal of Neural Transmission.2021; 128(4): 509. CrossRef - Suggestibility as a valuable criterion for laboratory-supported definite functional movement disorders
Gerard Saranza, Daniel Vargas-Mendez, Anthony E. Lang, Robert Chen
Clinical Neurophysiology Practice.2021; 6: 103. CrossRef - Peribuccal and pharyngeal myorhythmia as a presenting symptom of hypertrophic olivary degeneration: Expert commentary
Robert Chen
Parkinsonism & Related Disorders.2021; 85: 144. CrossRef - Nano‐dielectrics in biosystems
Jingjing Xu, Fan Wang, Yihan Song, Song Ge, Shengyong Xu
IET Nanodielectrics.2021; 4(4): 179. CrossRef - Jaw Pain and Oromandibular Dysfunction After a Complex Hospital Course
Sarah Smith, Ny-Ying Lam
American Journal of Physical Medicine & Rehabilitation.2021; 100(5): e62. CrossRef - Factors Influencing the Surgical Decision in Dystonia Patients Referred for Deep Brain Stimulation
Carolina Gorodetsky, Paula Azevedo, Carolina Candeias da Silva, Alfonso Fasano
Toxins.2021; 13(8): 511. CrossRef - Tremor Syndromes: An Updated Review
Abhishek Lenka, Joseph Jankovic
Frontiers in Neurology.2021;[Epub] CrossRef - The diagnostic value of clinical neurophysiology in hyperkinetic movement disorders: A systematic review
S. van der Veen, M.R. Klamer, J.W.J. Elting, J.H.T.M. Koelman, A.M.M. van der Stouwe, M.A.J. Tijssen
Parkinsonism & Related Disorders.2021; 89: 176. CrossRef - Wearable monitoring of positive and negative myoclonus in progressive myoclonic epilepsy type 1
Saara M. Rissanen, Jelena Hyppönen, Katri Silvennoinen, Laura Säisänen, Pasi A. Karjalainen, Esa Mervaala, Reetta Kälviäinen
Clinical Neurophysiology.2021; 132(10): 2464. CrossRef - Evaluation of movement and brain activity
Mark Hallett, Lourdes M. DelRosso, Rodger Elble, Raffaele Ferri, Fay B. Horak, Stephan Lehericy, Martina Mancini, Masao Matsuhashi, Riki Matsumoto, Muthuraman Muthuraman, Jan Raethjen, Hiroshi Shibasaki
Clinical Neurophysiology.2021; 132(10): 2608. CrossRef - Clinical and Psychological Aspects of Myoclonus in Different age Periods
Т.А. Литовченко, О.Ю. Сухоносова
Психиатрия, психотерапия и клиническая психология.2021; (2): 303. CrossRef - FEATURES OF EPILEPTIC MYOCLONIC SEIZURES IN PATIENTS AT DIFFERENT AGE PERIODS
T. A. Litovchenko, O. Yu. Sukhonosova, A. I. Ekzarkhova, S. M. Korenev, V. V. Salnikova, V. B. Olenich
International Medical Journal.2021; (4(108)): 61. CrossRef - Minimum Electromyographic Burst Duration in Healthy Controls: Implications for Electrodiagnosis in Movement Disorders
Alexis F. Collins, Steven T.R. Brown, Mark R. Baker
Movement Disorders Clinical Practice.2020; 7(7): 827. CrossRef - Physiology-Based Treatment of Myoclonus
Ashley B. Pena, John N. Caviness
Neurotherapeutics.2020; 17(4): 1665. CrossRef
- A review of treatment methods for movement disorders
Case Report
- Treatment of Hemichoreoathetosis with Arrhythmic Proximal Tremor after Stroke: The Role of Zona Incerta as a Target for Deep Brain Stimulation
- Andrei Koerbel, Augusto Radünz do Amaral, Helena Bedatti Zeh, Eduardo Wollmann, Renata Fabiola Heil Koerbel, Carla Moro, Alexandre Luiz Longo
- J Mov Disord. 2019;12(1):47-51. Published online January 30, 2019
- DOI: https://doi.org/10.14802/jmd.18032
- 9,687 View
- 125 Download
- 5 Web of Science
- 4 Crossref
-
Abstract
PDFSupplementary Material
- Deep brain stimulation (DBS) of the zona incerta has shown promising results in the reduction of medically refractory movement disorders. However, evidence supporting its efficacy in movement disorders secondary to hemorrhagic stroke or hemichoreoathetosis is limited. We describe a 48-year-old man who developed progressive hemichoreoathetosis with an arrhythmic, proximal tremor in his right arm following a thalamic hemorrhagic stroke. Pharmacological treatment was carried out with no change in the Abnormal Involuntary Movement Scale (AIMS) score after 4 weeks (14). After six sessions of botulinum toxin treatment, a subtle improvement in the AIMS score (13) was registered, but no clinical improvement was noted. The arrhythmic proximal movements were significantly improved after DBS of the zona incerta with a major decrease in the patient’s AIMS score (8). The response to DBS occurring after the failure of pharmacological and botulinum toxin treatments suggests that zona incerta DBS may be an alternative for postthalamic hemorrhage movement disorders.
-
Citations
Citations to this article as recorded by- Efficacy and safety of deep brain stimulation in mesencephalic locomotor region for motor function in patients with post-stroke hemiplegia: a study protocol for a multi-center double-blind crossover randomized controlled trial
Junpeng Xu, Bin Liu, Shuzhen Liu, Zhebin Feng, Yanyang Zhang, Di Liu, Qing Chang, Haonan Yang, Yuhan Chen, Xinguang Yu, Zhiqi Mao
Frontiers in Neurology.2024;[Epub] CrossRef - Deep brain stimulation for movement disorders after stroke: a systematic review of the literature
Mitch R. Paro, Michal Dyrda, Srinath Ramanan, Grant Wadman, Stacey-Ann Burke, Isabella Cipollone, Cory Bosworth, Sarah Zurek, Patrick B. Senatus
Journal of Neurosurgery.2022; : 1. CrossRef - Deep brain stimulation for post-thalamic stroke complex movement disorders
A. Macerollo, B. Hammersley, M. Bonello, J. Somerset, D. Bhargava, K. Das, J. Osman-Farah, P. R. Eldridge, S. H. Alusi
Neurological Sciences.2021; 42(1): 337. CrossRef - Neurologic Manifestations of Systemic Disease: Movement Disorders
Giulietta M. Riboldi, Steven J. Frucht
Current Treatment Options in Neurology.2021;[Epub] CrossRef
- Efficacy and safety of deep brain stimulation in mesencephalic locomotor region for motor function in patients with post-stroke hemiplegia: a study protocol for a multi-center double-blind crossover randomized controlled trial
Original Article
- Clinical Characteristics of Involuntary Movement in Hospitalized Patients
- Kyum-Yil Kwon, Hye Mi Lee, Seon-Min Lee, Seong-Beom Koh
- J Mov Disord. 2019;12(1):31-36. Published online December 20, 2018
- DOI: https://doi.org/10.14802/jmd.18040
- 9,899 View
- 237 Download
- 2 Web of Science
- 2 Crossref
-
Abstract
PDF
- Objective
Neurological symptoms in hospitalized patients are not rare, and neurological consultation for movement disorders is especially important in evaluating or managing those with various movement disorders. Therefore, we investigated a clinical pattern of in-hospital consultations for various movement disorders in a tertiary care university hospital.
Methods
Over two years, a total of 202 patients (70.7 ± 11.8 years of age) presenting with movement disorders referred to movement disorder specialists were investigated.
Results
The main symptoms referred by nonneurologists were tremor (56.9%), parkinsonism (16.8%), and gait disturbance (8.9%). The most frequent diagnostic category was toxic/metabolic-caused movement disorder (T/MCMD) (35%) with regard to medications, followed by Parkinson’s disease (PD) (16%). Regarding the mode of onset, T/MCMD was the leading cause for acute (68%) and subacute onset (46%), while PD was the leading disorder (31%) for chronic onset.
Conclusion
The current study showed a characteristic pattern of inpatients presenting with movement disorders. Furthermore, our findings highlighted the clinical significance of drug use or metabolic problems for treating this patient population. -
Citations
Citations to this article as recorded by- Pattern and frequency of involuntary movements: hospital-based study
H. N. El Tallawy, A. S. Shalash, M. A. Abdelhamed, R. E. Elsabrout
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery.2023;[Epub] CrossRef - Clinical Spectrum of Movement Disorders in Neurology Inpatients in a Tertiary Care Centre
Shabeer Ahmad Paul, Gouranga Prasad Mondal, Ramesh Bhattacharyya, Kartik Chandra Ghosh, Sarbajit Das, Suman Das, Hema Krishna, Chandrakanta Patra
Journal of Neurosciences in Rural Practice.2021; 12: 581. CrossRef
- Pattern and frequency of involuntary movements: hospital-based study
Case Report
- Holmes’ Tremor with Shoulder Pain Treated by Deep Brain Stimulation of Unilateral Ventral Intermediate Thalamic Nucleus and Globus Pallidus Internus
- Sabri Aydın, Huseyin Canaz, Ezgi Tuna Erdogan, Nazlı Durmaz, Barıs Topcular
- J Mov Disord. 2017;10(2):92-95. Published online April 18, 2017
- DOI: https://doi.org/10.14802/jmd.16051
- 9,998 View
- 129 Download
- 5 Web of Science
- 5 Crossref
-
Abstract
PDF
- A 21-year-old male was admitted with severe right arm and hand tremors after a thalamic hemorrhage caused by a traffic accident. He was also suffering from agonizing pain in his right shoulder that manifested after the tremor. Neurologic examination revealed a disabling, severe, and irregular kinetic and postural tremor in the right arm during target-directed movements. There was also an irregular ipsilateral rest tremor and dystonic movements in the distal part of the right arm. The amplitude was moderate at rest and extremely high during kinetic and intentional movements. The patient underwent left globus pallidum internus and ventral intermediate thalamic nucleus deep brain stimulation. The patient improved by more than 80% as rated by the Fahn-Tolosa-Marin Tremor Rating Scale and Visual Analog Scale six months after surgery.
-
Citations
Citations to this article as recorded by- Efficacy and safety of multiple-target deep brain stimulation in non-parkinsonian movement disorders: a systematic review
Evangelos Kalogirou, Spyridon Voulgaris, George A Alexiou
Neurosurgical Review.2025;[Epub] CrossRef - Holmes tremor: an updated review
Efstratios-Stylianos Pyrgelis, Eleni Agapiou, Efthalia Angelopoulou
Neurological Sciences.2022; 43(12): 6731. CrossRef - Deep brain stimulation of the posterior subthalamic area as an alternative strategy for management of Holmes tremor: A case report and review of the literature
Omid Yousefi, Mojtaba Dayyani, Razieh Rezaei, Hooman Kamran, Ali Razmkon
Surgical Neurology International.2022; 13: 489. CrossRef - Vim stereotactic radiosurgical thalamotomy for drug-resistant idiopathic Holmes tremor: a case report
Manjul Tripathi, Sahil Mehta, Raghav Singla, Chirag K. Ahuja, Naresh Tandalya, Constantin Tuleasca, Aman Batish, Sandeep Mohindra, Abhinav Agrahari, Rupinder Kaur
Acta Neurochirurgica.2021; 163(7): 1867. CrossRef - Deep brain stimulation in uncommon tremor disorders: indications, targets, and programming
Carlo Alberto Artusi, Ashar Farooqi, Alberto Romagnolo, Luca Marsili, Roberta Balestrino, Leonard L. Sokol, Lily L. Wang, Maurizio Zibetti, Andrew P. Duker, George T. Mandybur, Leonardo Lopiano, Aristide Merola
Journal of Neurology.2018; 265(11): 2473. CrossRef
- Efficacy and safety of multiple-target deep brain stimulation in non-parkinsonian movement disorders: a systematic review
Original Articles
- Movement Disorders in Non-Wilsonian Hepatic Cirrhotic Patients: The Subgroup Analysis of Various Phenotypes and Associated Risk Factors
- Kulthida Methawasin, Piyanant Chonmaitree, Chatchawan Wongjitrat, Suthee Rattanamongkolgul, Thanin Asawavichienjinda
- J Mov Disord. 2016;9(2):104-113. Published online March 28, 2016
- DOI: https://doi.org/10.14802/jmd.15047
- 21,466 View
- 98 Download
- 1 Web of Science
- 1 Crossref
-
Abstract
PDF
- Objective
The aim of this subgroup analysis was to identify the risk factors associated with the development of various movement disorder phenotypes.
Methods
Eighty-three non-Wilsonian cirrhotic patients with abnormal movements were allocated into the following groups: intention tremor, bradykinesia, Parkinsonism, and abnormal ocular movements. These movement types were considered the primary outcomes as there was a sufficient sample size. Researchers took into consideration the gender, etiologies of cirrhosis, cirrhosis-related complications, hepatic encephalopathy, medical illness, and some neurological deficits as potential factors associated with these movement disorders.
Results
The male gender (p = 0.002) and alcoholic cirrhosis (p = 0.005) were significant factors for the prevalence of intention tremors. In bradykinesia, hepatic encephalopathy was highly statistically significant (p < 0.001), and females more commonly developed bradykinesia (p = 0.04). The Parkinsonism features in this study were confounded by hyperlipidemia (p = 0.04) and motor or sensory deficits (p = 0.02). Jerky pursuits and a horizontal nystagmus were detected. Jerky pursuits were significantly related to hepatic encephalopathy (p = 0.003) and bradykinesia, but there were no factors associated with the prevalence of nystagmus other than an intention tremor.
Conclusions
The association of alcoholic cirrhosis with the development of intention tremor indicates that the persistent cerebellar malfunction in cirrhotic patients is due to alcohol toxicity. The slowness of finger tapping and jerky pursuit eye movements are significantly associated with hepatic encephalopathy. Thus, further studies are needed to evaluate the diagnostic value of these two signs for an early detection of mild hepatic encephalopathy. -
Citations
Citations to this article as recorded by- Unveiling the link: hepatitis C virus and Parkinson’s disease
Rasha Eletreby, Eman Elhady, Shaimaa Shaheen, Iman Hamza, Ahmed Hashem
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery.2024;[Epub] CrossRef
- Unveiling the link: hepatitis C virus and Parkinson’s disease
- Movement Disorders in Non-Wilsonian Cirrhotic Patients: A Report of the Prevalence and Risk Factors from a Study Done in a Medical School in an Agricultural-Based Community
- Kulthida Methawasin, Piyanant Chonmaitree, Chatchawan Wongjitrat, Suthee Rattanamongkolgul, Thanin Asawavichienjinda
- J Mov Disord. 2016;9(1):28-34. Published online December 3, 2015
- DOI: https://doi.org/10.14802/jmd.15034
- 21,935 View
- 86 Download
- 2 Crossref
-
Abstract
PDF
- Objective
Parkinsonism and other movement disorders have previously been reported in the acquired hepatocerebral degeneration associated with portosystemic shunting. However, there is no study to date about their prevalence as has been noted in general practice.
Methods
One hundred and forty-three patients with hepatic cirrhosis from the gastroenterology clinic and internal medicine wards were enrolled. Liver data included the diagnoses, etiologies, assessments of complications, and treatments for cirrhosis. Hepatic encephalopathy was classified with regard to the West Haven criteria for semi-quantitative grading for mental status. Neurological examination results and abnormal involuntary movements were recorded as primary outcomes. Neuro-radiology was used for the detection of severe brain lesions.
Results
Alcoholism was the most common cause of liver cirrhosis. Eighty-three patients (58%) presented with movement disorders. Asterixis was found in one of the cases. The most common movement disorder seen was an intentional tremor at 37.1%, which was followed by bradykinesia, Parkinsonism, and postural tremors at 29.4%, 10.5%, and 6.3%, respectively. The prevalence of movement disorders simultaneously increased with a high Child-Turcotte-Pugh score. The hepatic encephalopathy was grade 1 and 2. With the inclusion of age-range adjustments, we found that alcoholic cirrhosis and hepatic encephalopathy are statistically significant factors [p < 0.05, odds ratio (OR) = 6.41, 95% confidence interval (CI) 1.38–29.71 and p < 0.001, OR = 13.65, 95% CI 4.71–39.54] for the development of movement disorders in non-Wilsonian cirrhotic patients. Conclusions Intentional tremor is a common abnormal movement. Alcoholic cirrhosis and hepatic encephalopathy are significant risk factors in the development of movement disorders in non-Wilsonian cirrhotic patients. -
Citations
Citations to this article as recorded by- Investigating the Relationship between Chronic Liver Cirrhosis and Parkinsonism: A Comparative Analysis and a Suggested Diagnostic Scheme
Tal Sigawi, Omer Hamtzany, Noa Hurvitz, Yuval Ishay, Roy Dayan, David Arkadir, Yaron Ilan
Clinics and Practice.2024; 14(4): 1375. CrossRef - A Prospective Study of the Prevalence of Parkinsonism in Patients With Liver Cirrhosis
Diana Apetauerova, Peter Hildebrand, Stephanie Scala, Janet W. Zani, LeeAnne Lipert, Erin Clark, Tanya Fennell, Fredric D. Gordon
Hepatology Communications.2021; 5(2): 323. CrossRef
- Investigating the Relationship between Chronic Liver Cirrhosis and Parkinsonism: A Comparative Analysis and a Suggested Diagnostic Scheme
Case Reports
- Giant Middle Fossa Epidermoid Presenting as Holmes’ Tremor Syndrome
- Bindu Menon, P Sasikala, Amit Agrawal
- J Mov Disord. 2014;7(1):22-24. Published online April 30, 2014
- DOI: https://doi.org/10.14802/jmd.14005
- 12,074 View
- 68 Download
- 4 Web of Science
- 2 Crossref
-
Abstract
PDF
- Intracranial dermoids may gradually reach an enormous size before the onset of symptoms. Common clinical presentations of intracranial epidermoid include headache and seizures. We present a case of a 35-year female patient with giant middle fossa epidermoid that presented with Holmes’ tremor syndrome, and we review the relevant literature. To the best of our knowledge, such a presentation has not previously been described in the literature.
-
Citations
Citations to this article as recorded by- Holmes tremor
Gabriela B. Raina, Maria G. Cersosimo, Silvia S. Folgar, Juan C. Giugni, Cristian Calandra, Juan P. Paviolo, Veronica A. Tkachuk, Carlos Zuñiga Ramirez, Andrea L. Tschopp, Daniela S. Calvo, Luis A. Pellene, Marcela C. Uribe Roca, Miriam Velez, Rolando J.
Neurology.2016; 86(10): 931. CrossRef - Movement Disorders Following Cerebrovascular Lesions: Etiology, Treatment Options and Prognosis
Do-Young Kwon
Journal of Movement Disorders.2016; 9(2): 63. CrossRef
- Holmes tremor
- A Case of Intractable Psychogenic Essential Palatal Tremor
- Eun Joo Chung, Hyun Jung, Sang Jin Kim
- J Mov Disord. 2012;5(2):55-56.
- DOI: https://doi.org/10.14802/jmd.12013
- 15,004 View
- 81 Download
- 2 Crossref
-
Abstract
PDF
Essential palatal tremor (EPT) is a rare disorder which shows rhythmic involuntary movement of the muscles of soft palate, especially tensor veli palatini muscle. EPT is classified by two subtypes, which is primary and secondary EPT. Secondary EPT includes psychogenic type. We describe a case of intractable psychogenic EPT.
-
Citations
Citations to this article as recorded by- Essential palatal myoclonus with spontaneous resolution: a rare case report
Prakriti Lamichhane, Dirishya Bishowkarma, Saral Lamichhane, Shanti Sharma, Shankar Rimal
Annals of Medicine & Surgery.2025; 87(11): 7719. CrossRef - Botulinum toxin treatment for essential palatal tremors presenting with nasal clicks instead of pulsatile tinnitus: a case report
Yufeng Ye, Shiyu Liao, Baozhen Luo, Liyan Ni
Head & Face Medicine.2016;[Epub] CrossRef
- Essential palatal myoclonus with spontaneous resolution: a rare case report
- Dopa Responsive Slow Orthostatic Tremor in Parkinson’s Disease
- Suk Yoon Lee, Eun Joo Chung, Yeo Jung Kim, Sang Jin Kim
- J Mov Disord. 2011;4(2):82-84.
- DOI: https://doi.org/10.14802/jmd.11019
- 19,383 View
- 89 Download
- 7 Crossref
-
Abstract
PDF
Slow orthostatic tremor (OT) occurred to longer and lower frequency regular rhythmic bursts in leg muscle upon standing. The slow OT was often able to clinically confused with orthostatic myoclonus. We described a Parkinson’s disease patient with levodopa responsive slow OT. She showed abnormal movements of more regular rhythms and stable frequency on both legs on standing. These symptoms were aggravated at off state and improved by increasing levodopa.
-
Citations
Citations to this article as recorded by- Three hertz orthostatic tremor as "red flag sign" candidate for multiple system atrophy
Yuzhou Wang, Churong Liu, Wenhua Zheng, Mengyun Li, Xiaodi Li
Neurological Sciences.2025; 46(3): 1217. CrossRef - Orthostatic Tremor
José Fidel Baizabal-Carvallo, Joseph Jankovic
Seminars in Neurology.2025;[Epub] CrossRef - Tremor in Parkinson's Disease
Bart E. K. S. Swinnen, Arthur W. G. Buijink, Alberto J. Espay, Rob M. A. de Bie
Seminars in Neurology.2025;[Epub] CrossRef - Orthostatic myoclonus – A retrospective study of Asian patients
Yi-Cheng Tai, Hung-Chang Kuo, Yihui Wu, Shih-Pin Hsu
Journal of the Formosan Medical Association.2022; 121(7): 1310. CrossRef - Therapeutic Devices for Motor Symptoms in Parkinson’s Disease: Current Progress and a Systematic Review of Recent Randomized Controlled Trials
Joji Fujikawa, Ryoma Morigaki, Nobuaki Yamamoto, Teruo Oda, Hiroshi Nakanishi, Yuishin Izumi, Yasushi Takagi
Frontiers in Aging Neuroscience.2022;[Epub] CrossRef - Unilateral Pseudo-Orthostatic Tremor Provoked by a Remote Limb Movement in Parkinson’s Disease
Sang-Won Yoo, Youngje Heo, Joong-Seok Kim, Kwang-Soo Lee
Journal of Movement Disorders.2020; 13(1): 69. CrossRef - Levodopa-Responsive Primary Slow Orthostatic Tremor: A Premotor Sign of Parkinson’s Disease?
Fumihito Yoshii, Wakoh Takahashi, Koji Aono
Case Reports in Neurology.2020; 12(1): 1. CrossRef
- Three hertz orthostatic tremor as "red flag sign" candidate for multiple system atrophy
Original Articles
- Lateralized Effects of Unilateral Thalamotomy and Thalamic Stimulation in Patients with Essential Tremor
- Mi J. Kim, Sang R. Jeon, Sung R. Kim, Myoung C. Lee, Sun J. Chung
- J Mov Disord. 2011;4(2):64-67.
- DOI: https://doi.org/10.14802/jmd.11013
- 19,780 View
- 81 Download
- 9 Crossref
-
Abstract
PDF
Background and Purpose Stereotactic thalamotomy has been an effective surgical procedure in the treatment of medically refractory essential tremor (ET), however, little is known about the bilateral effects of unilateral ventralis intermedius (Vim) thalamotomy and Vim deep brain stimulation (DBS). We studied the lateralized effects of unilateral Vim thalamotomy and Vim DBS in ET patients.
Methods Vim thalamotomy was performed in 6 patients and Vim DBS in 6. Patients were evaluated preoperatively and at 3 and 6 months postoperatively using the Clinical Rating Scale for Tremor (CRST).
Results The contralateral Part A (tremor localization/severity rating) and Part B (specific motor tasks/function rating) subscores, and axial subscores of CRST significantly improved after unilateral Vim thalamotomy or Vim DBS. On the side ipsilateral to surgery, ET patients demonstrated no significant improvements in the Part A and Part B subscores of CRST. The Part C (functional disabilities resulting from tremor) subscores and total scores of CRST were significantly improved after surgery.
Conclusions Vim thalamotomy and DBS may be equally effective for the management of contralateral and axial tremor in ET patients, but both interventions may not improve tremor on the side ipsilateral to surgery.
-
Citations
Citations to this article as recorded by- Wearable peripheral nerve stimulator reduces essential tremor symptoms through targeted brain modulation
Cuong P. Luu, Jordan Ranum, Youngwon Youn, Jennifer L. Perrault, Bryan M. Krause, Matthew I. Banks, Laura Buyan-Dent, Kip A. Ludwig, Wendell B. Lake, Aaron J. Suminski
Brain Stimulation.2025; 18(4): 1162. CrossRef - Outcomes of stereotactic thalamotomy in patients of essential tremor: A systematic review
Sagun Ghimire, Bibechan Thapa, Durga Neupane, Pashupati Pokharel
Journal of Clinical Neuroscience.2024; 126: 38. CrossRef - Displaced center of pressure on the treated side in individuals with essential tremor after radiofrequency ablation: a longitudinal case–control study
Atsuya Sato, Takaomi Taira, Kazuya Kitada, Toshiki Ando, Toyohiro Hamaguchi, Michiko Konno, Yoshinori Kitabatake, Toshiyuki Ishioka
Frontiers in Neurology.2023;[Epub] CrossRef - Commentary on: A Network Approach to Understanding the Effects of Focused Ultrasound for Essential Tremor: Insights into Pathophysiology, Treatment, and Imaging Biomarkers
Prashin Unadkat, David Eidelberg
Neurotherapeutics.2022; 19(6): 1883. CrossRef - Deep Brain Stimulation for Tremor: Update on Long-Term Outcomes, Target Considerations and Future Directions
Naomi I. Kremer, Rik W. J. Pauwels, Nicolò G. Pozzi, Florian Lange, Jonas Roothans, Jens Volkmann, Martin M. Reich
Journal of Clinical Medicine.2021; 10(16): 3468. CrossRef - Clinical improvement associated with targeted interruption of the cerebellothalamic tract following MR-guided focused ultrasound for essential tremor
J. Levi Chazen, Harini Sarva, Philip E. Stieg, Robert J. Min, Douglas J. Ballon, Kane O. Pryor, Paul M. Riegelhaupt, Michael G. Kaplitt
Journal of Neurosurgery.2018; 129(2): 315. CrossRef - Innovations in Functional Neurosurgery and Anesthetic Implications
Lauren K. Dunn, Marcel E. Durieux, W. Jeffrey Elias, Edward C. Nemergut, Bhiken I. Naik
Journal of Neurosurgical Anesthesiology.2018; 30(1): 18. CrossRef - Surgical treatments for essential tremor
Rodger J. Elble, Ludy Shih, Jeffrey W. Cozzens
Expert Review of Neurotherapeutics.2018; 18(4): 303. CrossRef - The Current Status of Deep Brain Stimulation for the Treatment of Parkinson Disease in the Republic of Korea
Jung-Il Lee
Journal of Movement Disorders.2015; 8(3): 115. CrossRef
- Wearable peripheral nerve stimulator reduces essential tremor symptoms through targeted brain modulation
- Four Cases with Peripheral Trauma Induced Involuntary Movements
- Eun Joo Chung, Sang Jin Kim, Won Yong Lee, Jong Seok Bae, Eung Gyu Kim, Sung Hwa Pang
- J Mov Disord. 2010;3(2):39-41.
- DOI: https://doi.org/10.14802/jmd.10010
- 11,987 View
- 68 Download
- 3 Crossref
-
Abstract
PDF
Background and Purpose Although peripheral trauma induced movement disorders have been rarely reported, diagnostic criteria for peripherally induced movement disorders (PIMD) have been established. Because preexisting subclinical movement disorders, or secondary gain for compensation and legal purposes are difficult to confirm, differential diagnosis for physicians still remains difficult.
Case Reports We present four patients developed movement disorders after relatively various intervals after traffic accident. Three patients of them showed tremor and one patient presented propriospinal myoclonus. In this report, we investigate whether peripheral trauma can lead to movement disorders and describe the relationship between peripheral injury and movement disorders in four cases.
Conclusions Injury was serious enough to develop involuntary abnormal movements with pain and the latency between injury and the onset of movements in all of cases was less than 1 year. Thus, our cases showed temporal and anatomical correlation between injury and the onset of movement disorder, strongly supporting the cause-and-effect relationship by previous diagnostic criteria for peripherally induced movement disorders.
-
Citations
Citations to this article as recorded by- Diagnostic Utility of Clinical Neurophysiology in Jerky Movement Disorders: A Review from the MDS Clinical Neurophysiology Study Group
Anna Latorre, Christos Ganos, Masashi Hamada, Nicolas Phielipp, Lorenzo Rocchi, Shabbir Merchant, Marina A. Tijssen, Sterre van der Veen, Robert Chen
Movement Disorders Clinical Practice.2025; 12(3): 272. CrossRef - Early onset of propriospinal-like myoclonus in a child following a vertebral fracture
Carlotta Facini, Marina Barsacchi, Benedetta Piccolo, Emanuela Claudia Turco, Francesco Pisani
Neurology.2016; 87(9): 956. CrossRef - Propriospinal myoclonus: The spectrum of clinical and neurophysiological phenotypes
E. Antelmi, F. Provini
Sleep Medicine Reviews.2014;[Epub] CrossRef
- Diagnostic Utility of Clinical Neurophysiology in Jerky Movement Disorders: A Review from the MDS Clinical Neurophysiology Study Group
Case Reports
- Action Tremor Associated with Lamotrigine Monotherapy
- Ji-Hye Yang, Sung-Woo Chung, Joong-Seok Kim
- J Mov Disord. 2010;3(1):18-19.
- DOI: https://doi.org/10.14802/jmd.10005
- 11,996 View
- 81 Download
- 6 Crossref
-
Abstract
PDF
Lamotrigine (LTG) is associated with a tremor when given in combination with valproic acid; however, a tremor associated with lamotrigine monotherapy is rare. Here, we report a case of positional and action tremor associated with lamotrigine use. Based on the temporal relationship, it is conceivable that lamotrigine increases serotonin transmission or affects basal ganglia dopamine activity, thereby causing the tremor.
-
Citations
Citations to this article as recorded by- Tremor as an intrinsic feature of juvenile myoclonic epilepsy
Alessia Giugno, Francesco Fortunato, Ilaria Sammarra, Miriam Sturniolo, Enrico Fratto, Iolanda Martino, Rita Nisticò, Antonio Gambardella
Epilepsia.2025;[Epub] CrossRef - Drug-induced tremor
T. M. Ostroumova, V. A. Tolmacheva, O. D. Ostroumova
Neurology, Neuropsychiatry, Psychosomatics.2022; 14(2): 4. CrossRef - Movement disorders associated with antiseizure medications: A systematic review
Daniel J. Zhou, Spriha Pavuluri, Isha Snehal, Cynthia M. Schmidt, Miguel Situ-Kcomt, Olga Taraschenko
Epilepsy & Behavior.2022; 131: 108693. CrossRef - Antiseizure Drugs and Movement Disorders
Michel Sáenz-Farret, Marina A. J. Tijssen, Dawn Eliashiv, Robert S. Fisher, Kapil Sethi, Alfonso Fasano
CNS Drugs.2022; 36(8): 859. CrossRef - Akinetisch-rigide Bewegungsstörungen unter Antikonvulsiva
K. Kohlhase, S. Knake, L. Timmermann, F. Rosenow, A. Strzelczyk
DGNeurologie.2019; 2(4): 287. CrossRef - An Unusual Etiology of Vocal Tremor in a Professional Singer
Bridget L. Hopewell, Cristen Paige, David O. Francis
Journal of Voice.2019; 33(5): 730. CrossRef
- Tremor as an intrinsic feature of juvenile myoclonic epilepsy
- A Cerebellar Tremor in a Patient with Human Immunodeficiency Virus-1 Associated with Progressive Multifocal Leukoencephalopathy
- Hee-Jin Kim, Jae-Jung Lee, Phil Hyu Lee
- J Mov Disord. 2009;2(2):88-90.
- DOI: https://doi.org/10.14802/jmd.09024
- 65,535 View
- 48 Download
- 2 Crossref
-
Abstract
PDF
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system (CNS) caused by JC virus infection in oligodendrocytes, especially in patients with acquired immunodeficiency syndrome (AIDS). Movement disorders associated with PML are very rare. Here, we report a case of PML in an AIDS patient who presented with a cerebellar tremor, caused by lesions in the cerebellar outflow tract. A cerebellar tremor can be a rare clinical manifestation in patients with PML.
-
Citations
Citations to this article as recorded by- Holmes tremor in progressive multifocal leukoencephalopathy: A video case report
Takako Matsushima, Ryotaro Ikeguchi, Mutsumi Iijima, Ayato Shimomura, Shuntaro Takahashi, Kazuo Nakamichi, Yuko Shimizu, Kazuo Kitagawa
Clinical and Experimental Neuroimmunology.2024; 15(2): 101. CrossRef - Holmes tremor caused by a natalizumab-related progressive multifocal leukoencephalopathy: a case report and brief review of the literature
Luca Magistrelli, Domizia Vecchio, Paola Naldi, Cristoforo Comi, Roberto Cantello
Neurological Sciences.2019; 40(9): 1943. CrossRef
- Holmes tremor in progressive multifocal leukoencephalopathy: A video case report
- Disabling Head Tremor in a Patient with DYT1 Mutation
- Jae-Hyeok Lee, Dae-Seong Kim, Jae-Wook Cho, Kyung-Pil Park
- J Mov Disord. 2009;2(2):86-87.
- DOI: https://doi.org/10.14802/jmd.09023
- 62,066 View
- 41 Download
- 1 Crossref
-
Abstract
PDF
Dystonic head tremor is known to be a feature in some patients with DYT1 mutation. However, isolated tremor of the head without relevant cervical dystonia has rarely been described. We report here a patient with the three-bp GAG deletion in the DYT1 gene (904_906delGAG) who had severe head tremor in the frame of a generalized limb dystonia.
-
Citations
Citations to this article as recorded by- Head tremor at disease onset: an ataxic phenotype of cervical dystonia
Aristide Merola, Alok K. Dwivedi, Aasef G. Shaikh, Tamour Khan Tareen, Gustavo A. Da Prat, Marcelo A. Kauffman, Jennie Hampf, Abhimanyu Mahajan, Luca Marsili, Joseph Jankovic, Cynthia L. Comella, Brian D. Berman, Joel S. Perlmutter, Hyder A. Jinnah, Alber
Journal of Neurology.2019; 266(8): 1844. CrossRef
- Head tremor at disease onset: an ataxic phenotype of cervical dystonia
Original Article
- Unilateral Standing Leg Tremor as the Initial Manifestation of Parkinson Disease
- Suk Yun Kang, Sook-Keun Song, Jin-Soo Kim, Young Ho Sohn
- J Mov Disord. 2009;2(1):29-32.
- DOI: https://doi.org/10.14802/jmd.09007
- 14,933 View
- 105 Download
- 4 Crossref
-
Abstract
PDF
Background: The aim of this study was to analyze the different forms of leg tremors exhibited while standing in patients with Parkinson disease (PD), and to determine if the type of leg tremor exhibited is indicative of prognosis or treatment response in PD patients.
Methods: We studied the clinical characteristics of five PD patients (all women; mean age, 59 years, range, 53–64 years) with unilateral standing leg tremor as the initial manifestation of PD, including their electrophysiological findings and the results of long-term follow-up.
Results: For each patient, parkinsonism either existed at the time of onset of the initial symptoms or developed later. Patient responses to drugs were generally good, but one patient showed a poor response to drugs, even though she had only a low frequency leg tremor. For two patients whom we could observe during the 10-year follow-up period, neither the leg tremor nor parkinsonism was aggravated.
Conclusions: There are two forms of unilateral standing leg tremor in PD. One form is high frequency, similar to the primary orthostatic tremor. The other is low frequency and similar to the parkinsonian resting tremor. Based on these observations, it appears that progression might be slow if PD patients have standing leg tremor as the initial manifestation.
-
Citations
Citations to this article as recorded by- Tremor in Parkinson's Disease
Bart E. K. S. Swinnen, Arthur W. G. Buijink, Alberto J. Espay, Rob M. A. de Bie
Seminars in Neurology.2025;[Epub] CrossRef - Orthostatic tremor as initial presentation of Parkinson’s disease
Y R Chiew
QJM: An International Journal of Medicine.2023; 116(7): 549. CrossRef - The ‘Postural Rhythm’ of the Ground Reaction Force during Upright Stance and Its Conversion to Body Sway—The Effect of Vision, Support Surface and Adaptation to Repeated Trials
Stefania Sozzi, Shashank Ghai, Marco Schieppati
Brain Sciences.2023; 13(7): 978. CrossRef - An unusual initial presentation of Parkinson’s disease: unilateral standing leg tremor
Jasem Yousef Al-Hashel, Walaa Ahmed Kamel, Philippe Damier, Ahmad Jasem Abdulsalam
Acta Neurologica Belgica.2020; 120(2): 415. CrossRef
- Tremor in Parkinson's Disease
Review Article
- Electrophysiologic Assessments of Involuntary Movements: Tremor and Myoclonus
- Hyun-Dong Park, Hee-Tae Kim
- J Mov Disord. 2009;2(1):14-17.
- DOI: https://doi.org/10.14802/jmd.09004
- 20,508 View
- 289 Download
- 6 Crossref
-
Abstract
PDF
Tremor is defined as a rhythmical, involuntary oscillatory movement of a body part. Although neurological examination reveals information regarding its frequency, regularity, amplitude, and activation conditions, the electrophysiological investigations help in confirming the tremor, in differentiating it from other hyperkinetic disorders like myoclonus, and may provide etiological clues. Accelerometer with surface electromyogram (EMG) can be used to document the dominant frequency of a tremor, which may be useful as certain frequencies are more characteristic of specific etiologies than others hyperkinetic disorders. It may show rhythmic bursts, duration and activation pattern (alternating or synchronous). Myoclonus is a quick, involuntary movement. Electrophysiological studies may helpful in the evaluation of myoclonus, not only for confirming the clinical diagnosis but also for understanding the underlying physiological mechanisms. Electroencephalogram (EEG)-EMG correlates can give us important information about myoclonus. Jerk-locked back-averaging and evoked potentials with recording of the long-latency, long-loop reflexes are currently available to study the pathophysiology of myoclonus.
-
Citations
Citations to this article as recorded by- Adaptation of Transcortical Responses in Upper Extremity Movements During an Elbow Visuomotor Tracking Task in Humans
Olga Dubey, Michael A. Petrie, Richard K. Shields
Journal of Functional Morphology and Kinesiology.2025; 10(4): 368. CrossRef - DBS in tremor with dystonia: VIM, GPi or both? A review of the literature and considerations from a single-center experience
Davide Paoli, Russell Mills, Una Brechany, Nicola Pavese, Claire Nicholson
Journal of Neurology.2023; 270(4): 2217. CrossRef - Posthypoxic Segmental Spinal “Flutter”-Like Myoclonus
Boby V Maramattom
Neurology India.2022; 70(5): 2202. CrossRef - The diagnostic value of clinical neurophysiology in hyperkinetic movement disorders: A systematic review
S. van der Veen, M.R. Klamer, J.W.J. Elting, J.H.T.M. Koelman, A.M.M. van der Stouwe, M.A.J. Tijssen
Parkinsonism & Related Disorders.2021; 89: 176. CrossRef - How can neurophysiological studies help with movement disorders characterization in clinical practice? A review
Talyta GRIPPE, Natalia Spinola Costa da CUNHA, Pedro Renato de Paula BRANDÃO, Rubens Nelson Morato FERNANDEZ, Francisco Eduardo Costa CARDOSO
Arquivos de Neuro-Psiquiatria.2020; 78(8): 512. CrossRef - Epileptic and non-epileptic paroxysmal motor phenomena in newborns
Carlotta Facini, Carlotta Spagnoli, Francesco Pisani
The Journal of Maternal-Fetal & Neonatal Medicine.2016; 29(22): 3652. CrossRef
- Adaptation of Transcortical Responses in Upper Extremity Movements During an Elbow Visuomotor Tracking Task in Humans
Case Report
- A Case of Familial Cortical Myoclonic Tremor With Epilepsy
- Kang-Ho Choi, Tai-Seung Nam, Seong-Min Choi
- J Mov Disord. 2008;1(2):93-96.
- DOI: https://doi.org/10.14802/jmd.08018
- 13,016 View
- 73 Download
-
Abstract
PDF
Familial cortical myoclonic tremor with epilepsy (FCMTE) is a rare disorder characterized by irregular postural tremor of the limbs, family history of seizures, autosomal dominant inheritance, and a rather benign course. A 23 year-old man who had a history of seizure attack since age 16 showed postural and kinetic tremor and mental retardation (MR). His older sister as well as his mother had similar clinical feature. We report the first case of FCMTE in Korea.
First
Prev
