Objective
To explore the central aortic pressure in patients with Parkinson’s disease (PD).
Methods
We investigated central arterial stiffness by measurement of the augmentation index (AIx) in PD patients. Patients were eligible for the study if they were de novo PD and 45 years of age or older. The patients’ demographics, vascular risk factors, and neurologic examinations were collected at baseline. The AIx was measured by applanation tonometry.
Results
A total of 147 subjects (77 in control and 70 in PD groups) were enrolled in the study. While there was no significant difference in peripheral systolic blood pressure (SBP), diastolic blood pressure (DBP), or mean arterial pressure between groups, peripheral pulse pressure (PP) was significantly lower in the PD group than in the control group (p = 0.012). Regarding central pressure, aortic DBP was significantly higher and PP was significantly lower in the PD group (p = 0.001, < 0.0001). Although there was no significant difference in the AIx between the groups, a trend toward a lower AIx was observed in the PD group (31.2% vs. 28.1%, p = 0.074).
Conclusion
This study showed that peripheral and central PP was significantly lower in the PD group than in the control group. Our study suggests that PD patients may have a low risk of a cardiovascular event by reason of a lower PP.
Citations
Citations to this article as recorded by
Central Aortic Pressure and Arterial Stiffness in Parkinson’s Disease: A Comparative Study Mehmet Balal, Meltem Demirkiran, Saime Paydas, Seyed-Mohammad Fereshtehnejad Parkinson's Disease.2022; 2022: 1. CrossRef
Selected autonomic signs and symptoms as risk markers for phenoconversion and functional dependence in prodromal Parkinson’s disease Cameron Miller-Patterson, Jesse Y. Hsu, Lana M. Chahine, James F. Morley, Allison W. Willis Clinical Autonomic Research.2022; 32(6): 463. CrossRef
VEGF Signaling in Neurological Disorders Joon Shim, Joseph Madsen International Journal of Molecular Sciences.2018; 19(1): 275. CrossRef