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Original Article
A Comparative Study of Central Hemodynamics in Parkinson’s Disease
Joong Hyun Park, Sang Won Han, Jong Sam Baik
J Mov Disord. 2017;10(3):135-139.   Published online August 31, 2017
DOI: https://doi.org/10.14802/jmd.17035
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  • 3 Web of Science
  • 3 Crossref
AbstractAbstract PDF
Objective
To explore the central aortic pressure in patients with Parkinson’s disease (PD).
Methods
We investigated central arterial stiffness by measurement of the augmentation index (AIx) in PD patients. Patients were eligible for the study if they were de novo PD and 45 years of age or older. The patients’ demographics, vascular risk factors, and neurologic examinations were collected at baseline. The AIx was measured by applanation tonometry.
Results
A total of 147 subjects (77 in control and 70 in PD groups) were enrolled in the study. While there was no significant difference in peripheral systolic blood pressure (SBP), diastolic blood pressure (DBP), or mean arterial pressure between groups, peripheral pulse pressure (PP) was significantly lower in the PD group than in the control group (p = 0.012). Regarding central pressure, aortic DBP was significantly higher and PP was significantly lower in the PD group (p = 0.001, < 0.0001). Although there was no significant difference in the AIx between the groups, a trend toward a lower AIx was observed in the PD group (31.2% vs. 28.1%, p = 0.074).
Conclusion
This study showed that peripheral and central PP was significantly lower in the PD group than in the control group. Our study suggests that PD patients may have a low risk of a cardiovascular event by reason of a lower PP.

Citations

Citations to this article as recorded by  
  • Central Aortic Pressure and Arterial Stiffness in Parkinson’s Disease: A Comparative Study
    Mehmet Balal, Meltem Demirkiran, Saime Paydas, Seyed-Mohammad Fereshtehnejad
    Parkinson's Disease.2022; 2022: 1.     CrossRef
  • Selected autonomic signs and symptoms as risk markers for phenoconversion and functional dependence in prodromal Parkinson’s disease
    Cameron Miller-Patterson, Jesse Y. Hsu, Lana M. Chahine, James F. Morley, Allison W. Willis
    Clinical Autonomic Research.2022; 32(6): 463.     CrossRef
  • VEGF Signaling in Neurological Disorders
    Joon Shim, Joseph Madsen
    International Journal of Molecular Sciences.2018; 19(1): 275.     CrossRef

JMD : Journal of Movement Disorders