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Original Article
Comparison of Pallidal and Subthalamic Deep Brain Stimulation in Parkinson’s Disease: Therapeutic and Adverse Effects
Ho-Sung Ryu, Mi-Sun Kim, Sooyeoun You, Mi-Jung Kim, Young Jin Kim, Juyeon Kim, Kiju Kim, Sun Ju Chung
J Mov Disord. 2017;10(2):80-86.   Published online May 8, 2017
DOI: https://doi.org/10.14802/jmd.17001
  • 8,264 View
  • 253 Download
  • 6 Web of Science
  • 7 Crossref
AbstractAbstract PDFSupplementary Material
Objective
To compare the therapeutic and adverse effects of globus pallidus interna (GPi) and subthalamic nucleus (STN) deep brain stimulation (DBS) for the treatment of advanced Parkinson’s disease (PD).
Methods
We retrospectively analyzed the clinical data of patients with PD who underwent GPi (n = 14) or STN (n = 28) DBS surgery between April 2002 and May 2014. The subjects were matched for age at surgery and disease duration. The Unified Parkinson’s Disease Rating Scale (UPDRS) scores and levodopa equivalent dose (LED) at baseline and 12 months after surgery were used to assess the therapeutic effects of DBS. Adverse effects were also compared between the two groups.
Results
At 12 months, the mean changes in the UPDRS total and part I–IV scores did not differ significantly between the two groups. However, the subscores for gait disturbance/postural instability and dyskinesia were significantly more improved after GPi DBS than those after STN DBS (p = 0.024 and 0.016, respectively). The LED was significantly more reduced in patients after STN DBS than that after GPi DBS (p = 0.004). Serious adverse effects did not differ between the two groups (p = 0.697).
Conclusion
The patients with PD showed greater improvement in gait disturbance/postural instability and dyskinesia after GPi DBS compared with those after STN DBS, although the patients had a greater reduction in LED after STN DBS. These results may provide useful information for optimal target selection for DBS in PD.

Citations

Citations to this article as recorded by  
  • Long-term motor outcomes of deep brain stimulation of the globus pallidus interna in Parkinson's disease patients: Five-year follow-up
    Yun Su Hwang, Sungyang Jo, Seung Hyun Lee, Nayoung Kim, Mi-Sun Kim, Sang Ryong Jeon, Sun Ju Chung
    Journal of the Neurological Sciences.2023; 444: 120484.     CrossRef
  • The Role of Microelectrode Recording in Deep Brain Stimulation Surgery for Parkinson’s Disease: A Systematic Review and Meta-Analysis
    R. Saman Vinke, Martin Geerlings, Ashok K. Selvaraj, Dejan Georgiev, Bastiaan R. Bloem, Rianne A.J. Esselink, Ronald H.M.A. Bartels
    Journal of Parkinson's Disease.2022; 12(7): 2059.     CrossRef
  • Motor Thalamic Deep Brain Stimulation Alters Cortical Activity and Shows Therapeutic Utility for Treatment of Parkinson’s Disease Symptoms in a Rat Model
    Heidi R. Tucker, Emily Mahoney, Kainat Akhtar, Tzu-Jen Kao, Gianna Mamone, Saisree Mikkilineni, Maya Ravi, Hanel Watkins, Danielle-Lee Terrelonge, Caryn Martin, Kristen Unger, Gabrielle Kim, Kyra Fiber, Megan Gupta, Jonathan Indajang, Eliyahu M. Kochman,
    Neuroscience.2021; 460: 88.     CrossRef
  • Current Knowledge on the Background, Pathophysiology and Treatment of Levodopa-Induced Dyskinesia—Literature Review
    Michał Hutny, Jagoda Hofman, Aleksandra Klimkowicz-Mrowiec, Agnieszka Gorzkowska
    Journal of Clinical Medicine.2021; 10(19): 4377.     CrossRef
  • Estimating Risk for Future Intracranial, Fully Implanted, Modular Neuroprosthetic Systems: A Systematic Review of Hardware Complications in Clinical Deep Brain Stimulation and Experimental Human Intracortical Arrays
    Autumn J. Bullard, Brianna C. Hutchison, Jiseon Lee, Cynthia A. Chestek, Parag G. Patil
    Neuromodulation: Technology at the Neural Interface.2020; 23(4): 411.     CrossRef
  • Long-term Effects of Bilateral Subthalamic Deep Brain Stimulation on Postural Instability and Gait Difficulty in Patients with Parkinson’s Disease
    Hae-Won Shin, Mi Sun Kim, Sung Reul Kim, Sang Ryong Jeon, Sun Ju Chung
    Journal of Movement Disorders.2020; 13(2): 127.     CrossRef
  • Treatment strategies in advanced Parkinson's disease: Review of the literature
    Yıldız Değirmenci
    Cumhuriyet Medical Journal.2017; 39(3): 509.     CrossRef
Case Report
Globus Pallidus Interna Deep Brain Stimulation in a Patient with Medically Intractable Meige Syndrome
Dae-Woong Bae, Byung-chul Son, Joong-Seok Kim
J Mov Disord. 2014;7(2):92-94.   Published online October 30, 2014
DOI: https://doi.org/10.14802/jmd.14013
  • 13,324 View
  • 101 Download
  • 6 Web of Science
  • 7 Crossref
AbstractAbstract PDF
Medical therapies in patients with Meige syndrome, including botulinum toxin injection, have been limited because of incomplete response or adverse side effects. We evaluated a patient with Meige syndrome who was successfully treated with deep brain stimulation (DBS) in the globus pallidus interna (GPi). This case report and other previous reports suggest that bilateral GPi DBS may be an effective treatment for medically refractory Meige syndrome, without significant adverse effects.

Citations

Citations to this article as recorded by  
  • Pallidal versus subthalamic deep brain stimulation for Meige syndrome: A systematic review and meta-analysis
    Xin Wu, Tao Xue, Shiqing Pan, Weikang Xing, Chuanjun Huang, Jianguo Zhang, Guozheng Zhao
    Heliyon.2024; 10(6): e27945.     CrossRef
  • Bilateral pallidal DBS for blepharospasm: A case report and review of the literature
    Joshua Lucas, Dorian Kusyk, Donald Whiting
    Surgical Neurology International.2022; 13: 200.     CrossRef
  • Blepharospasm, Oromandibular Dystonia, and Meige Syndrome: Clinical and Genetic Update
    Hongying Ma, Jian Qu, Liangjun Ye, Yi Shu, Qiang Qu
    Frontiers in Neurology.2021;[Epub]     CrossRef
  • Pallidal versus subthalamic deep-brain stimulation for meige syndrome: a retrospective study
    Jiayu Liu, Hu Ding, Ke Xu, Ruen Liu, Dongliang Wang, Jia Ouyang, Zhi Liu, Zeyu Miao
    Scientific Reports.2021;[Epub]     CrossRef
  • Predictive factors for long-term clinical outcomes of deep brain stimulation in the treatment of primary Meige syndrome
    Xin Wang, Zhiqi Mao, Zhiqiang Cui, Xin Xu, Longsheng Pan, Shuli Liang, Zhipei Ling, Xinguang Yu
    Journal of Neurosurgery.2020; 132(5): 1367.     CrossRef
  • Long-Term Efficacy of Deep Brain Stimulation of Bilateral Globus Pallidus Internus in Primary Meige Syndrome
    Hong Tian, Yanbing Yu, Xueke Zhen, Li Zhang, Yue Yuan, Bo Zhang, Liang Wang
    Stereotactic and Functional Neurosurgery.2019; 97(5-6): 356.     CrossRef
  • Meige's syndrome: History, epidemiology, clinical features, pathogenesis and treatment
    Sanjay Pandey, Soumya Sharma
    Journal of the Neurological Sciences.2017; 372: 162.     CrossRef

JMD : Journal of Movement Disorders