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- Efficacy and safety of zolpidem for musician’s dystonia
- Shiro Horisawa, Kilsoo Kim, Masato Murakami, Masahiko Nishitani, Takakazu Kawamata, Takaomi Taira
- Received May 20, 2024 Accepted June 28, 2024 Published online July 1, 2024
- DOI: https://doi.org/10.14802/jmd.24121 [Accepted]
- 965 View
- 65 Download
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Abstract
PDF - Background
The efficacy and safety of zolpidem in treating musician’s dystonia are not well understood.
Objective
We aimed to retrospectively investigate the efficacy and safety of zolpidem for musician’s dystonia.
Methods
We retrospectively reviewed medical records between January 2021 and December 2023 to identify patients with musician’s dystonia who had been prescribed zolpidem. The Tubiana’s musician’s dystonia rating scale (range, 1-5; lower scores indicating greater severity) was used to evaluate musician’s dystonia.
Results
Fifteen patients were included in this study. The mean effective dose of zolpidem was 5.3±2.0 mg. The mean effective duration of zolpidem was 4.3±1.2 h. With zolpidem administration, the Tubiana’s musician’s dystonia rating scale score significantly improved from 2.2±1.0 to 4.3±0.8 (48.9% improvement, p<0.001). Two patients (13.3%) discontinued the drug owing to unsatisfactory results or sleepiness.
Conclusion
This study suggests that zolpidem may be an alternative treatment option for musician’s dystonia.
Case Report
- A Case with Improvement of Blepharospasm by Zolpidem
- Munkyung Sunwoo, Junghee Cho, Jun Hong Lee, Gyu Sik Kim, Jong Hun Kim, Sun-Ah Choi
- J Mov Disord. 2011;4(1):53-54.
- DOI: https://doi.org/10.14802/jmd.11010
- 21,616 View
- 65 Download
- 3 Crossref
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Abstract
PDF
Zolpidem is usually used for the treatment of insomnia as a hypnotic drug. It was also suggested to be effective in the treatment of dystonia in some studies. A 74-year-old woman had been suffering from frequent and intense bilateral spasms of the eyelids for 20 years. She has been treated with botulinum toxin injection and taken some medications. But, she experienced a little effect and was not satisfied with those treatments. Her symptom was improved after taking Zolpidem which had been prescribed for insomnia by her primary physician. She did not show any improvement after placebo injection and neostigmine test. This is the first report which shows improvement of isolated blepharospasm by Zolpidem in Korea. Zolpidem can be one of useful alternative pharmacological treatments for blepharospasm. Further randomized, blinded, placebo-controlled studies are needed to validate this finding.
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Citations
Citations to this article as recorded by
- Zolpidem for the Treatment of Dystonia
Stephanie Patricia J. Badillo, Roland Dominic G. Jamora
Frontiers in Neurology.2019;[Epub] CrossRef - Can a Positive Allosteric Modulation of GABAergic Receptors Improve Motor Symptoms in Patients with Parkinson’s Disease? The Potential Role of Zolpidem in the Treatment of Parkinson’s Disease
Antonio Daniele, Francesco Panza, Antonio Greco, Giancarlo Logroscino, Davide Seripa
Parkinson's Disease.2016; 2016: 1. CrossRef - Medical treatment of dystonia
Pichet Termsarasab, Thananan Thammongkolchai, Steven J. Frucht
Journal of Clinical Movement Disorders.2016;[Epub] CrossRef
- Zolpidem for the Treatment of Dystonia
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