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Brief communication
COVID-19 Vaccine-Related Movement Disorders: A Systematic Review
Grace Elysse D. Angeles, Lowrence Precious C. Dichoso, Roland Dominic G. Jamora
Received January 2, 2024  Accepted March 18, 2024  Published online March 19, 2024  
DOI:    [Epub ahead of print]
  • 1,142 View
  • 79 Download
AbstractAbstract PDFSupplementary Material
Since the release of vaccines against coronavirus disease 2019 (COVID-19), there have been reports of vaccine-related neurologic complications. This study aimed to perform a descriptive systematic review of movement disorders associated with COVID-19 vaccines.
We described the demographics, clinical presentation, management, outcomes, and proposed pathomechanism of the patients. A systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A standardized tool was used to assess the quality of the cases.
We identified 8 articles that met our inclusion criteria; these articles included 10 patients who developed movement disorders after vaccination. The majority were males (n = 8), with a median age of 64.5 years. The most common movement disorder was hemichorea. The rest presented with generalized chorea with myoclonus, cervical dystonia, and akathisia. Most patients respond to immunotherapy. The standardized tool used showed that most studies had a low risk of bias.
The reported incidence of vaccine-related movement disorders was low based on available published cases.
Review Article
Management of Parkinson’s Disease in the COVID-19 Pandemic and Future Perspectives in the Era of Vaccination
Yue Hui Lau, Keng Ming Lau, Norlinah Mohamed Ibrahim
J Mov Disord. 2021;14(3):177-183.   Published online July 29, 2021
  • 6,955 View
  • 156 Download
  • 11 Web of Science
  • 7 Crossref
AbstractAbstract PDF
The current coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARSCoV- 2) has led to a serious global health crisis. Increasing evidence suggests that elderly individuals with underlying chronic diseases, including Parkinson’s disease (PD), are particularly vulnerable to this infection. Changes in the routine care of PD patients should be implemented carefully without affecting the quality provided. The utilization of telemedicine for clinical consultation, assessment and rehabilitation has also been widely recommended. Therefore, the aim of this review is to provide recommendations in the management of PD during the pandemic as well as in the early phase of vaccination programs to highlight the potential sequelae and future perspectives of vaccination and further research in PD. Even though a year has passed since COVID- 19 emerged, most of us are still facing great challenges in providing a continuum of care to patients with chronic neurological disorders. However, we should regard this health crisis as an opportunity to change our routine approach in managing PD patients and learn more about the impact of SARS-CoV-2. Hopefully, PD patients can be vaccinated promptly, and more detailed research related to PD in COVID-19 can still be carried out.


Citations to this article as recorded by  
  • Increasing exercise with a mobile app in people with Parkinson’s disease: a pilot study
    Jong Hyeon Ahn, Dongrul Shin, Dongyeong Lee, Hye Young Kim, Jinyoung Youn, Jin Whan Cho, Suzanne Kuys
    Brain Impairment.2024;[Epub]     CrossRef
  • Potential convergence of olfactory dysfunction in Parkinson’s disease and COVID-19: The role of neuroinflammation
    Hui Li, Junliang Qian, Youcui Wang, Juan Wang, Xiaoqing Mi, Le Qu, Ning Song, Junxia Xie
    Ageing Research Reviews.2024; 97: 102288.     CrossRef
  • A large survey on COVID-19 vaccination in patients with Parkinson’s disease and healthy population
    Chao Han, Zhen Zhen Zhao, Piu Chan, Fang Li, Chun Ling Chi, Xin Zhang, Yan Zhao, Jing Chen, Jing Hong Ma
    Vaccine.2023; 41(43): 6483.     CrossRef
  • Role of SARS-CoV-2 in Modifying Neurodegenerative Processes in Parkinson’s Disease: A Narrative Review
    Jeremy M. Morowitz, Kaylyn B. Pogson, Daniel A. Roque, Frank C. Church
    Brain Sciences.2022; 12(5): 536.     CrossRef
  • Deep Learning Paradigm for Cardiovascular Disease/Stroke Risk Stratification in Parkinson’s Disease Affected by COVID-19: A Narrative Review
    Jasjit S. Suri, Mahesh A. Maindarkar, Sudip Paul, Puneet Ahluwalia, Mrinalini Bhagawati, Luca Saba, Gavino Faa, Sanjay Saxena, Inder M. Singh, Paramjit S. Chadha, Monika Turk, Amer Johri, Narendra N. Khanna, Klaudija Viskovic, Sofia Mavrogeni, John R. Lai
    Diagnostics.2022; 12(7): 1543.     CrossRef
  • Movement disorders in COVID-19 times: impact on care in movement disorders and Parkinson disease
    Sabrina Poonja, K. Ray Chaudhuri, Janis M. Miyasaki
    Current Opinion in Neurology.2022; 35(4): 494.     CrossRef
  • Viruses, parkinsonism and Parkinson’s disease: the past, present and future
    Valentina Leta, Daniele Urso, Lucia Batzu, Yue Hui Lau, Donna Mathew, Iro Boura, Vanessa Raeder, Cristian Falup-Pecurariu, Daniel van Wamelen, K. Ray Chaudhuri
    Journal of Neural Transmission.2022; 129(9): 1119.     CrossRef
Case Report
An Elderly Case of Acute Cerebellitis after Alleged Vaccination
Kang Min Park, Si Eun Kim, Sung Eun Kim
J Mov Disord. 2012;5(1):21-23.
  • 13,103 View
  • 64 Download
  • 2 Crossref
AbstractAbstract PDF

Acute cerebellitis (AC) is a benign and self-limiting inflammatory disease. It typically occurs as a primary infectious or postinfectious disorder. Although AC mostly presents in early childhood, it can appear in adult. A 66-year-old man admitted to our hospital because of limb and gait ataxia. Three weeks ago, he took an influenza vaccination. There was no abnormality on brain MRI with contrast enhancement, but Technetium-99m hexamethyl propylene amine oxime-single photon emission computed tomography (HMPAO-SPECT) showed markedly cerebellar asymmetry, suggesting hypoperfusion in the right cerebellum. Influenza vaccination can cause AC in the elderly and brain HMPAO-SPECT imaging is more useful than MRI in identifying patients with AC.


Citations to this article as recorded by  
  • Acute cerebellitis following COVID‐19 vaccination: A case report
    Seyedehnarges Tabatabaee, Fahimeh H. Akhoundi, Afsaneh Khobeydeh, Seyed Mohammad Tabatabaei, Bahram Haghi Ashtiani
    Clinical Case Reports.2023;[Epub]     CrossRef
  • Advanced neuroimaging findings of pseudotumoral hemicerebellitis in an elderly male requiring surgical decompression
    Rajesh Gupta, Pejman J. Maralani, Sanjeev Chawla, Pallavi P. Gopal, Suyash Mohan
    Journal of Neurosurgery.2014; 120(2): 522.     CrossRef
Original Article
Psychogenic Gait Disorders after Mass School Vaccination of Influenza A
Jung Ho Ryu, Jong Sam Baik
J Mov Disord. 2010;3(1):15-17.
  • 8,047 View
  • 34 Download
  • 5 Crossref
AbstractAbstract PDF
Background and Purpose

Psychogenic movement disorders (PMD) after war or mass vaccination was reported and well known disease entity already. However, we have seldom been met those patients because we don’t have any chance to experience of those events. Recently, influenza A (H1N1) spreads around world, and many countries have a program of mass vaccination of H1N1. Although PMD in adult is well characterized, childhood-onset PMD has not been extensively studied.

Case Reports

We present four children of psychogenic gait disorders (PGDs) after mass school vaccination of H1N1. They had fluctuating weakness and their prognosis was good. We confirmed all patients as PGD by placebo.


Our four cases have two common characteristics. One is that all were young and their prognosis was good. And the other is that all were induced their abnormal gait symptoms after mass school vaccination. We observed that mass PMD has a different characteristics comparing to personal PMD, and PMD in children is differ from adult onset PMD.


Citations to this article as recorded by  
  • Diagnosing Common Movement Disorders in Children
    Jennifer A. O’Malley
    CONTINUUM: Lifelong Learning in Neurology.2022; 28(5): 1476.     CrossRef
  • Immunization stress-related responses: Implications for vaccination hesitancy and vaccination processes during the COVID-19 pandemic
    Steven Taylor, Gordon J.G. Asmundson
    Journal of Anxiety Disorders.2021; 84: 102489.     CrossRef
  • Functional Neurological Disorder after Vaccination: A Balanced Approach Informed by History
    Stefanie C Linden, Alan J Carson, Simon Wessely
    Journal of the Royal College of Physicians of Edinburgh.2021; 51(4): 330.     CrossRef
  • Psychogenic Gait Disorder Complicating Recovery after Concussion: A Case Series
    Scott I. Otallah
    Pediatric Neurology.2020;[Epub]     CrossRef
  • Psychogenic movement disorders in children and adolescents: an update
    Susan R. Harris
    European Journal of Pediatrics.2019; 178(4): 581.     CrossRef

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