Objective aaThe aim of this study was to investigate frontal N30 status in Parkinson’s disease (PD) and to examine the correlation between the amplitude of frontal N30 and the severity of motor deficits.
Methods aaThe frontal N30 was compared between 17 PD patients and 18 healthy volunteers. Correlations between the amplitude of frontal N30 and the Unified Parkinson’s Disease Rating Scale (UPDRS) motor score of the more severely affected side was examined.
Results aaThe mean latency of the N30 was not significantly different between patients and healthy volunteers (p = 0.981), but the mean amplitude was lower in PD patients (p < 0.025). There was a significant negative correlation between the amplitude of N30 and the UPDRS motor score (r = -0.715, p = 0.013).
Conclusions The frontal N30 status indicates the motor severity of PD. It can be a useful biomarker reflecting dopaminergic deficits and an objective measurement for monitoring the clinical severity of PD.
Citations
Citations to this article as recorded by
A Comparison of Sensorimotor Integration and Motor Fitness Components between Collegiate Athletes with and without Long COVID: A Cross-Sectional Study with Pair-Matched Controls Ibrahim M. Moustafa, Amal Ahbouch, Raheesa P. Kader, Tamer Mohamed Shousha, Abdulla Alrahoomi Journal of Clinical Medicine.2024; 13(9): 2469. CrossRef
The Effects of Chiropractic Spinal Adjustment on EEG in Adults with Alzheimer's and Parkinson's Disease: A Pilot Randomised Cross-over Trial Muhammad Samran Navid, Imran Khan Niazi, Kelly Holt, Rasmus Bach Nedergaard, Imran Amjad, Usman Ghani, Nitika Kumari, Muhammad Shafique, Jenna Duehr, Robert J. Trager, Heidi Haavik Journal of Integrative Neuroscience.2024;[Epub] CrossRef
Spatial discrimination in patients with MSA, PSP, DIP, and VP with pain Min Seung Kim, Jaeho Kim, Suk Yun Kang Scientific Reports.2024;[Epub] CrossRef
Clinical factors affecting evoked magnetic fields in patients with Parkinson's disease Ryoji Naganuma, Ichiro Yabe, Megumi Takeuchi, Kirari Morishita, Shingo Nakane, Ryoken Takase, Ikuko Takahashi-Iwata, Masaaki Matsushima, Mika Otsuki, Hideaki Shiraishi, Hidenao Sasaki, Wing-ho Yung PLOS ONE.2020; 15(9): e0232808. CrossRef
Short-Term Effects of Thoracic Spine Manipulation on the Biomechanical Organisation of Gait Initiation: A Randomized Pilot Study Sébastien Ditcharles, Eric Yiou, Arnaud Delafontaine, Alain Hamaoui Frontiers in Human Neuroscience.2017;[Epub] CrossRef