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1 "Unified Parkinson’s Disease Rating Scale"
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Original Article
Rapid Eye Movement Sleep Behavior Disorder in Parkinson’s Disease: A Preliminary Study
Chang Soo Kim, Young Hee Sung, Min Ju Kang, Kee Hyung Park
J Mov Disord. 2016;9(2):114-119.   Published online March 2, 2016
DOI: https://doi.org/10.14802/jmd.15039
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  • 8 Citations
AbstractAbstract PDF
Objective
Rapid eye movement sleep behavior disorder (RBD) is associated with α-synucleinopathies, such as Parkinson’s disease (PD). We aimed to assess the differences in the clinical characteristics of PD with and without RBD.
Methods
Forty-two patients previously diagnosed with PD were evaluated for clinical history, motor and cognitive functioning using the Unified Parkinson’s Disease Rating Scale (UPDRS) and Mini-Mental State Examination (MMSE), autonomic symptoms, sleep characteristics using the Pittsburg Sleep Quality Index (PSQI), and the presence of RBD using the Korean version of the RBD screening questionnaire (RBDSQ). The prevalence of RBD and the patients’ demographic features were evaluated. The patients were classified into two groups, PD with RBD and PD without RBD, based on the RBDSQ scores. The motor and cognitive functions, as well as other clinical features of the two groups were compared.
Results
A total of 42 PD patients were enrolled. Eighteen patients were classified as PD with RBD. Compared to PD without RBD, PD with RBD showed higher scores of rigidity in the UPDRS subscale. Regarding sleep problems, PD with RBD revealed higher sleep disturbance, lower sleep efficiency, and lower overall sleep quality in the PSQI. There was no difference in cognitive dysfunction between the two groups according to the Korean version of the MMSE.
Conclusions
PD with RBD was associated with poorer sleep and motor symptoms. Therefore, RBD symptoms in PD are possibly poor prognostic markers.

Citations

Citations to this article as recorded by  
  • Cerebellar Microstructural Abnormalities in Parkinson’s Disease: a Systematic Review of Diffusion Tensor Imaging Studies
    Maryam Haghshomar, Parnian Shobeiri, Seyed Arsalan Seyedi, Fatemeh Abbasi-Feijani, Amirhossein Poopak, Houman Sotoudeh, Arash Kamali, Mohammad Hadi Aarabi
    The Cerebellum.2022; 21(4): 545.     CrossRef
  • A data-driven system to identify REM sleep behavior disorder and to predict its progression from the prodromal stage in Parkinson's disease
    Matteo Cesari, Julie A.E. Christensen, Maria-Lucia Muntean, Brit Mollenhauer, Friederike Sixel-Döring, Helge B.D. Sorensen, Claudia Trenkwalder, Poul Jennum
    Sleep Medicine.2021; 77: 238.     CrossRef
  • Impact of Obstructive Sleep Apnea on Cognitive and Motor Functions in Parkinson's Disease
    Mohamed Elfil, Eshak I. Bahbah, Mahmoud M. Attia, Mohamed Eldokmak, Brian B. Koo
    Movement Disorders.2021; 36(3): 570.     CrossRef
  • Sleep Disorders and Cognitive Dysfunctions in Parkinson’s Disease: A Meta-Analytic Study
    Gianpaolo Maggi, Luigi Trojano, Paolo Barone, Gabriella Santangelo
    Neuropsychology Review.2021; 31(4): 643.     CrossRef
  • Risk stratification for REM sleep behavior disorder in patients with Parkinson’s disease: A PRISMA-compliant meta-analysis and systematic review
    Chengjuan Xie, Mingyu Zhu, Ying Hu
    Clinical Neurology and Neurosurgery.2021; 202: 106484.     CrossRef
  • REM sleep behavior disorder portends poor prognosis in Parkinson’s disease: A systematic review
    Yoon Kim, Young Eun Kim, Eun Ok Park, Chae Won Shin, Han-Joon Kim, Beomseok Jeon
    Journal of Clinical Neuroscience.2018; 47: 6.     CrossRef
  • Prevalence of rapid eye movement sleep behavior disorder (RBD) in Parkinson’s disease: a meta and meta-regression analysis
    Xiaona Zhang, Xiaoxuan Sun, Junhong Wang, Liou Tang, Anmu Xie
    Neurological Sciences.2017; 38(1): 163.     CrossRef
  • Clinical variations in Parkinson’s disease patients with or without REM sleep behaviour disorder: a meta-analysis
    Ruo-lin Zhu, Cheng-juan Xie, Pan-pan Hu, Kai Wang
    Scientific Reports.2017;[Epub]     CrossRef

JMD : Journal of Movement Disorders