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Original Articles
- The Association between the Triglyceride-Glucose Index and the Incidence Risk of Parkinson’s Disease: A Nationwide Cohort Study
- Yoonkyung Chang, Ju-young Park, Ji Young Yun, Tae-Jin Song
- J Mov Disord. 2025;18(2):138-148. Published online February 27, 2025
- DOI: https://doi.org/10.14802/jmd.24131
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- 110 Download
- 5 Web of Science
- 5 Crossref
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Abstract
PDF
Supplementary Material - Objective
We aimed to investigate the associations of the triglyceride-glucose index, which measures insulin resistance, and the incidence of Parkinson’s disease.
Methods
Our study used the Health Screening Cohort database of the National Health Insurance Service of South Korea (2002–2019). We included 310,021 participants who had no previous history of Parkinson’s disease and for whom more than 3 triglyceride-glucose index measurements were available. A diagnosis of Parkinson’s disease was determined via the International Classification of Diseases Tenth edition (G20) with a specific reimbursement code for rare intractable diseases and a history of prescriptions for anti-Parkinsonism drugs.
Results
During a median of 9.64 years (interquartile range 8.72–10.53), 4,587 individuals (1.5%) had Parkinson’s disease. Based on a multivariable time-dependent Cox proportional hazards model, a per-unit increase in triglyceride-glucose index score was associated with a significantly increased risk of Parkinson’s disease (hazard ratio [HR]: 1.062; 95% confidence interval [CI] 1.007–1.119). In a sensitivity analysis, the triglyceride-glucose index was associated with the incidence of Parkinson’s disease in a non–diabetes mellitus cohort (HR: 1.093; 95% CI 1.025–1.165), but not in the diabetes mellitus cohort (HR: 0.990; 95% CI 0.902–1.087). In a restricted cubic spline analysis, the association between the triglyceride-glucose index and the incidence risk of Parkinson’s disease showed a nonlinear increasing (J-shaped) trend.
Conclusion
Our study demonstrated that higher triglyceride-glucose index scores were associated with the incidence of Parkinson’s disease in the general population, particularly in a nondiabetic mellitus cohort. -
Citations
Citations to this article as recorded by
- Association between the triglyceride-glucose frailty index and Parkinson's disease in middle-aged and older adults: a comparative cross-national analysis of NHANES and CHARLS
Changze Ou, Binbin Chen, Haidong Yu, Jun Deng, Huajun Long
Parkinsonism & Related Disorders.2026; 145: 108240. CrossRef - Insulin Resistance Surrogates and Cognitive Impairment in Parkinson’s Disease: A Cross-Sectional Study with Interpretable Machine Learning
Hongming Liang, Yuru Jia, Hui Zhang, Danlei Wang, Haoheng Yu, Yongwen Yan, Jingyi Li, Liangkai Chen, Zheng Xue
Biomedicines.2026; 14(3): 493. CrossRef - The interplay between obesity and triglyceride-glucose index in modulating Parkinson's disease risk: A cross-sectional NHANES study of middle-aged and young adults
Jincheng Ma, Mimi Li, Zhendong Lei
Parkinsonism & Related Disorders.2025; 140: 108070. CrossRef - Revisiting the Triglyceride–Glucose Index in Parkinson’s Disease: Risk Ractor or Disease Marker?
Shweta Prasad, Tarunya Nagaraj, Shubha GS Bhat, Mahima Bhardwaj, Pooja Mailankody, Rohan R Mahale, Nitish Kamble, Vikram Venkappayya Holla, Ravi Yadav, Pramod Kumar Pal
Journal of Movement Disorders.2025; 18(4): 389. CrossRef - Association of triglyceride glucose-waist to height ratio index with Parkinson’s disease and the mediating role of systemic inflammatory response index: A cross-sectional study
Keyu Shi, Zikai Pei, Sijie Quan, Yue Shi, Yi Zhou
Medicine.2025; 104(52): e46737. CrossRef
- Association between the triglyceride-glucose frailty index and Parkinson's disease in middle-aged and older adults: a comparative cross-national analysis of NHANES and CHARLS
- Efficacy and Safety of Taltirelin Hydrate in Patients With Ataxia Due to Spinocerebellar Degeneration
- Jin Whan Cho, Jee-Young Lee, Han-Joon Kim, Joong-Seok Kim, Kun-Woo Park, Seong-Min Choi, Chul Hyoung Lyoo, Seong-Beom Koh
- J Mov Disord. 2025;18(1):35-44. Published online October 21, 2024
- DOI: https://doi.org/10.14802/jmd.24127
- Correction in: https://doi.org/
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Abstract
PDFSupplementary Material
- Objective
We conducted this study to assess the efficacy and safety of taltirelin hydrate (TH) in patients with ataxia due to spinocerebellar degeneration (SCD).
Methods
Patients were randomly assigned to either the taltirelin group (5 mg orally, twice daily) or the control group. The primary endpoint was the change in the Korean version of the Scale for the Assessment and Rating of Ataxia (K-SARA) score at 24 weeks. The secondary endpoints included changes in the K-SARA score at 4 and 12 weeks as well as the Clinical Global Impression Scale, the five-level version of the EuroQol five-dimensional questionnaire, the Tinetti balance test, and gait analysis at 4, 12, and 24 weeks.
Results
A total of 149 patients (hereditary:nonhereditary=86:63) were enrolled. There were significant differences in the change in the K-SARA score at 24 weeks from baseline between the taltirelin group and the control group (-0.51±2.79 versus 0.36±2.62, respectively; p=0.0321). For the K-SARA items, the taltirelin group had significantly lower “Stance” and “Speech disturbance” subscores than the control group (-0.04±0.89 versus 0.23±0.79 and -0.07±0.74 versus 0.18±0.67; p=0.0270 and 0.0130, respectively). However, there were no significant differences in changes in other secondary efficacy outcome measures at 24 weeks from baseline between the two treatment arms (p>0.05).
Conclusion
Clinicians might consider the use of TH in the treatment of patients with ataxia due to SCD. -
Citations
Citations to this article as recorded by- Taltirelin treatment alleviates PTSD-like symptoms and restores neural oscillations in male mice receiving single prolonged stress
Keke Ding, Zhengrong Zhang, Jingwen Niu, Mingyue Zhu, Junjie Zhang, Lixia Chen, Shaojie Yang, Jingji Wang, Guoqi Zhu
Neuropharmacology.2026; 284: 110791. CrossRef - Long-term efficacy and disease-specific responsiveness to protirelin in patients with spinocerebellar degeneration: A retrospective study
Shohei Okusa, Toshiki Tezuka, Jin Nakahara, Morinobu Seki
Parkinsonism & Related Disorders.2026; 145: 108238. CrossRef
- Taltirelin treatment alleviates PTSD-like symptoms and restores neural oscillations in male mice receiving single prolonged stress
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