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Original Article
- Taltirelin Hydrate in Patients with Ataxia Due to Spinocerebellar Degeneration
- Jin Whan Cho, Jee-Young Lee, Han-Joon Kim, Joong-Seok Kim, Kun-Woo Park, Seong-Min Choi, Chul Hyoung Lyoo, Seong-Beom Koh
- Received May 28, 2024 Accepted October 18, 2024 Published online October 21, 2024
- DOI: https://doi.org/10.14802/jmd.24127 [Accepted]
- 465 View
- 85 Download
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Abstract
PDF - Objective
We conducted this study to assess the efficacy and safety of taltirelin hydrate (TH) in spinocerebellar degeneration (SCD).
Methods
Patients were randomly assigned to either the taltirelin group (5 mg orally, twice daily) or the control group. The primary endpoint was changes in the Korean version of Scale for the Assessment and Rating of Ataxia (K-SARA) scores at 24 weeks. The secondary endpoints include changes in the K-SARA scores at 4 and 12 weeks, the Clinical Global Impression, Five-level version of the EuroQol five-dimensional questionnaire, Tinetti balance test and gait analysis at 4, 12 and 24 weeks.
Results
A total of 149 patients (hereditary:non-hereditary = 86:63) were enrolled. There were significant differences in changes in K-SARA scores at 24 weeks from baseline between the taltirelin group and the control group (-0.51 ± 2.79 versus 0.36 ± 2.62, respectively; p = 0.0321). Of the K-SARA items, both ‘Stance’ and ‘Speech disturbance’ had significantly lower subscores in the taltirelin group as compared with the control group (-0.04 ± 0.89 versus 0.23 ± 0.79 and -0.07 ± 0.74 versus 0.18 ± 0.67; p = 0.0270 and 0.0130, respectively). But there were no significant differences in changes in other secondary efficacy outcome measures at 24 weeks from baseline between the two treatment arms (p > 0.05).
Conclusion
Clinicians might consider using TH in the treatment of ataxia due to SCD.
Case Report
- Jaw Dystonia Induced by Speaking
- Jong-Sam Baik, Jae-Hyeon Park, Jeong-Yeon Kim, Sang-Won Han
- J Mov Disord. 2008;1(1):55-57.
- DOI: https://doi.org/10.14802/jmd.08010
- 17,203 View
- 88 Download
- 1 Crossref
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Abstract
PDF
We describe a 43-year-old housewife who presented with dysarthria suddenly because her masseter muscles contracted bilaterally, when she was speaking. Brain MRI showed focal signal change on midbrain. Jaw dystonia induced by speaking is very rare and we chose an anticholinergic medication, rather than botulinumtoxin injection. Her condition was markedly improved after medication. We suspected that her symptoms were related with focal lesion, so she had secondary jaw dystonia induced by speaking.
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Citations
Citations to this article as recorded by
- Non-occupational task-specific masticatory dystonia
Sang-Won Yoo, In-Seok Park, Hyung-Eun Park, Joong-Seok Kim
Neurological Sciences.2015; 36(2): 339. CrossRef
- Non-occupational task-specific masticatory dystonia
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