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Review Article
- Environmental Risk Factors for Progressive Supranuclear Palsy
- Hee Kyung Park, Sindana D. Ilango, Irene Litvan
- J Mov Disord. 2021;14(2):103-113. Published online May 26, 2021
- DOI: https://doi.org/10.14802/jmd.20173
- 10,053 View
- 275 Download
- 5 Web of Science
- 7 Crossref
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Abstract
PDF - Typically, progressive supranuclear palsy (PSP) is clinically characterized by slow vertical saccades or supranuclear gaze palsy, levodopa-resistant parkinsonism with predominant axial symptoms, and cognitive executive impairment. Over the past decades, various PSP phenotypes, including PSP with predominant parkinsonism, PSP with corticobasal syndrome, PSP with progressive gait freezing, and PSP with predominant frontal dysfunction, have been identified from pathologically confirmed cases. Expanding knowledge led to new diagnostic criteria for PSP that with increased disease awareness led to increased PSP prevalence estimates. The identification of environmental and modifiable risk factors creates an opportunity to intervene and delay the onset of PSP or slow disease progression. To date, despite the increasing number of publications assessing risk factors for PSP, few articles have focused on environmental and lifestyle risk factors for this disorder. In this article, we reviewed the literature investigating the relationship between PSP and several environmental and other modifiable lifestyle risk factors. In our review, we found that exposures to toxins related to diet, metals, well water, and hypertension were associated with increased PSP risk. In contrast, higher education and statins may be protective. Further case-control studies are encouraged to determine the exact role of these factors in the etiopathogenesis of PSP, which in turn would inform strategies to prevent and reduce the burden of PSP.
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Citations
Citations to this article as recorded by
- Parkinson’s Disease is Predominantly a Genetic Disease
Shen-Yang Lim, Christine Klein
Journal of Parkinson's Disease.2024; : 1. CrossRef - Progressive supranuclear palsy’s economical burden: the use and costs of healthcare resources in a large health provider in Israel
Yael Barer, Raanan Cohen, Meital Grabarnik-John, Xiaolan Ye, Jorge Zamudio, Tanya Gurevich, Gabriel Chodick
Journal of Neurology.2023; 270(8): 3770. CrossRef - The Pesticide Chlordecone Promotes Parkinsonism-like Neurodegeneration with Tau Lesions in Midbrain Cultures and C. elegans Worms
Valeria Parrales-Macias, Patrick P. Michel, Aurore Tourville, Rita Raisman-Vozari, Stéphane Haïk, Stéphane Hunot, Nicolas Bizat, Annie Lannuzel
Cells.2023; 12(9): 1336. CrossRef - The prevalence and incidence of progressive supranuclear palsy and corticobasal syndrome: a systematic review and meta-analysis
Shane Lyons, Dominic Trépel, Tim Lynch, Richard Walsh, Sean O’Dowd
Journal of Neurology.2023; 270(9): 4451. CrossRef - Analysis of Genetic and MRI Changes, Blood Markers, and Risk Factors in a Twin Pair Discordant of Progressive Supranuclear Palsy
Aliz Persely, Beatrix Beszedics, Krisztina Paloczi, Marton Piroska, Amirreza Alijanpourotaghsara, David Strelnikov, Arsalan Vessal, Helga Szabo, Anita Hernyes, Luca Zoldi, Zsofia Jokkel, Andrea Fekete, Janos Juhasz, Nora Makra, Dora Szabo, Edit Buzas, Ada
Medicina.2023; 59(10): 1696. CrossRef - Dementia Prevention in Clinical Practice
Kellyann Niotis, Kiarra Akiyoshi, Caroline Carlton, Richard Isaacson
Seminars in Neurology.2022; 42(05): 525. CrossRef - Progressive Supranuclear Palsy in 2022: recent developments and an eye to the future
Shane Lyons, Sean O'Dowd, Richard Walsh, Tim Lynch
Advances in Clinical Neuroscience & Rehabilitation.2022;[Epub] CrossRef
- Parkinson’s Disease is Predominantly a Genetic Disease
Brief communication
- Risk Factors for Falls in Patients with de novo Parkinson’s Disease: A Focus on Motor and Non-Motor Symptoms
- Kyum-Yil Kwon, Mina Lee, Hyunjin Ju, Kayeong Im
- J Mov Disord. 2020;13(2):142-145. Published online May 29, 2020
- DOI: https://doi.org/10.14802/jmd.20009
- 5,406 View
- 181 Download
- 7 Web of Science
- 7 Crossref
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Abstract
PDF
- Objective
We aimed to identify risk factors for falls in patients with de novo Parkinson’s disease (PD). Methods Forty-six patients with de novo PD were retrospectively included in the study. We assessed details on the patients’ motor symptoms as well as non-motor symptoms using several representative scales for global cognition, depression, fatigue, and dysautonomia. Fallers and non-fallers were identified according to their history of falls during the preceding year. Results Twenty-two patients (45.8%) with de novo PD had a history of falls. Compared with the non-faller group, the faller group exhibited higher scores for postural instability/gait difficulty (PIGD), anxiety, fatigue, total dysautonomia, gastrointestinal dysfunction, and thermoregulatory dysfunction. Moreover, logistic regression analysis showed that falling was positively correlated with anxiety and gastrointestinal symptoms but negatively associated with the tremor scores. Conclusion Our findings suggest that falling in patients with de novo PD is significantly associated with PIGD/non-tremor symptoms, anxiety, and gastrointestinal dysfunction. -
Citations
Citations to this article as recorded by- Association Between Gait and Dysautonomia in Patients With De Novo Parkinson’s Disease: Forward Gait Versus Backward Gait
Seon-Min Lee, Mina Lee, Eun Ji Lee, Rae On Kim, Yongduk Kim, Kyum-Yil Kwon
Journal of Movement Disorders.2023; 16(1): 59. CrossRef - Fluctuations in Upper and Lower Body Movement during Walking in Normal Pressure Hydrocephalus and Parkinson’s Disease Assessed by Motion Capture with a Smartphone Application, TDPT-GT
Chifumi Iseki, Shou Suzuki, Tadanori Fukami, Shigeki Yamada, Tatsuya Hayasaka, Toshiyuki Kondo, Masayuki Hoshi, Shigeo Ueda, Yoshiyuki Kobayashi, Masatsune Ishikawa, Shigenori Kanno, Kyoko Suzuki, Yukihiko Aoyagi, Yasuyuki Ohta
Sensors.2023; 23(22): 9263. CrossRef - Associations of cognitive dysfunction with motor and non-motor symptoms in patients with de novo Parkinson’s disease
Kyum-Yil Kwon, Suyeon Park, Rae On Kim, Eun Ji Lee, Mina Lee
Scientific Reports.2022;[Epub] CrossRef - Initial Vestibular Function May Be Associated with Future Postural Instability in Parkinson’s Disease
Jeong Ho Park, Min Seung Kim, Suk Yun Kang
Journal of Clinical Medicine.2022; 11(19): 5608. CrossRef - Association of fall risk factors and non-motor symptoms in patients with early Parkinson’s disease
Kyum-Yil Kwon, Suyeon Park, Eun Ji Lee, Mina Lee, Hyunjin Ju
Scientific Reports.2021;[Epub] CrossRef - Understanding the influence of pain and fatigue on physical performance, fear of falling and falls in people with Parkinson’s disease: a pilot study
Hanan Khalil, Nesreen Alissa, Alham Al-Sharman, Islam E’leimat, Majdi Al Qawasmeh, Khalid El-Salem
Neurodegenerative Disease Management.2021; 11(2): 113. CrossRef - Assessment of Risk Factors for Falls among Patients with Parkinson’s Disease
Jacek Wilczyński, Magdalena Ścipniak, Kacper Ścipniak, Kamil Margiel, Igor Wilczyński, Rafał Zieliński, Piotr Sobolewski, Stefano Brunelli
BioMed Research International.2021; 2021: 1. CrossRef
- Association Between Gait and Dysautonomia in Patients With De Novo Parkinson’s Disease: Forward Gait Versus Backward Gait
Original Article
- Falls and Their Associated Risks in Parkinson’s Disease Patients in Nigeria
- Temitope Hannah Farombi, Mayowa O Owolabi, Adesola Ogunniyi
- J Mov Disord. 2016;9(3):160-165. Published online September 21, 2016
- DOI: https://doi.org/10.14802/jmd.16011
- 18,568 View
- 232 Download
- 17 Web of Science
- 15 Crossref
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Abstract
PDF
- Objective
Falls are a devastating consequence of Parkinson’s disease (PD) and are due to motor imbalance. However, the frequency of falls and their risk factors among Nigerians with PD is not known despite the significant increase in PD cases in the country. To assess fall risk factors and frequency in Nigerian PD patients.
Methods
Using an analytical design to compare falling versus non-falling patients, 81 PD patients were assessed for clinical factors, frequency of falls, and candidate risk factors for falls according to the Tinetti Balance and Gait, Unified Parkinson’s Disease Rating Scale subsection 1, and Timed Up and Go Tests. Descriptive, bivariate, and multivariate analyses were performed at the 95% confidence level.
Results
The mean age of participants was 65.6 ± 9.7 years. Falls were about three times (p < 0.001) more common in PD patients. Of the falling patients, 67.7% sustained injuries, 67.7% had recurrent falls and 44.9% admitted to having a fear of falling. The independent statistical predictors of fall were fear of falling [odds ratio (OR): 3.86], disease severity (OR: 1.09) and disease duration (OR: 1.01).
Conclusion
The frequency of falls in PD patients was significantly higher when compared with the healthy adult population, and the modifiable predictor was fear of falling with a potential to significantly reduce falls when strategically addressed. -
Citations
Citations to this article as recorded by- Concept Mapping to Define Components for an Occupation-Based Intervention for Parkinson’s Disease and Anxiety
Christopher J. Lovegrove, Ingrid H.W.M. Sturkenboom, Jonathan Marsden, Katrina Bannigan
Journal of Parkinson's Disease.2024; 14(1): 181. CrossRef - α‐Synuclein aggregation causes muscle atrophy through neuromuscular junction degeneration
Qiumei Yang, Yanyan Wang, Chunsong Zhao, Shimin Pang, Jing Lu, Piu Chan
Journal of Cachexia, Sarcopenia and Muscle.2023; 14(1): 226. CrossRef - Toxin Induced Parkinsonism and Hospitalization Related Adverse Outcome Mitigation for Parkinson’s Disease: A Comprehensive Review
Kenneth R. Dalton, Charles J. Kidd, Nawaz Hack
Journal of Clinical Medicine.2023; 12(3): 1074. CrossRef - Smart Assistance to Reduce the Fear of Falling in Parkinson Patients Using IoT
Pratik Bhattacharjee, Suparna Biswas, Samiran Chattopadhyay, Sandip Roy, Sandip Chakraborty
Wireless Personal Communications.2023; 130(1): 281. CrossRef - PRIORITIZING FALL RISK MANAGEMENT: IRRESPECTIVE OF PARKINSON’S DISEASE PROGRESSION DURING REHABILITATION
Fakhir Ansari
Pakistan Journal of Rehabilitation.2023; 12(1): 84. CrossRef - Frequency, pattern and predictors of cognitive impairments in patients with Parkinson’s disease using the Community Screening Instrument for Dementia
Ewere Marie Ogbimi, Fatai Momodu Akemokwe, Olubunmi Ogunrin
Frontiers in Human Neuroscience.2023;[Epub] CrossRef - Cognitive status and sleep quality can explain the fear of falling and fall history in people with Parkinson’s disease
Nesreen Alissa, Reem Rehan, Alham Al-Sharman, Mariem Latrous, Ala’ S Aburub, Khalid El-Salem, Linzette Morris, Hanan Khalil
International Journal of Rehabilitation Research.2023; 46(4): 338. CrossRef - Clinical Disease Severity Mediates the Relationship between Stride Length and Speed and the Risk of Falling in Parkinson’s Disease
Yun-Ru Lai, Chia-Yi Lien, Chih-Cheng Huang, Wei-Che Lin, Yueh-Sheng Chen, Chiun-Chieh Yu, Ben-Chung Cheng, Chia-Te Kung, Chien-Feng Kung, Yi-Fang Chiang, Yun-Ting Hung, Hsueh-Wen Chang, Cheng-Hsien Lu
Journal of Personalized Medicine.2022; 12(2): 192. CrossRef - Avaliação do risco de quedas entre pessoas com doença de Parkinson
Franciny da Silva, Angela Maria Alvarez, Simony Fabíola Lopes Nunes, Maria Eduarda Massari Silva, Silvia Maria Azevedo Dos Santos
Escola Anna Nery.2022;[Epub] CrossRef - Sarcopenia in Patients With Parkinson's Disease: A Systematic Review and Meta-Analysis
Yingying Cai, Fei Feng, Qianqian Wei, Zheng Jiang, Ruwei Ou, Huifang Shang
Frontiers in Neurology.2021;[Epub] CrossRef - Peripheral vestibular system: Age-related vestibular loss and associated deficits
Jennifer Coto, Carmen L. Alvarez, Ivette Cejas, Brett M. Colbert, Bonnie E. Levin, Joshua Huppert, Tatjana Rundek, Carey Balaban, Susan H. Blanton, David J. Lee, David Loewenstein, Michael Hoffer, Xue Zhong Liu
Journal of Otology.2021; 16(4): 258. CrossRef - Clinical correlates of sarcopenia and falls in Parkinson’s disease
Danielle Pessoa Lima, Samuel Brito de Almeida, Janine de Carvalho Bonfadini, João Rafael Gomes de Luna, Madeleine Sales de Alencar, Edilberto Barreira Pinheiro-Neto, Antonio Brazil Viana-Júnior, Samuel Ranieri Oliveira Veras, Manoel Alves Sobreira-Neto, J
PLOS ONE.2020; 15(3): e0227238. CrossRef - Parkinson's Disease Research on the African Continent: Obstacles and Opportunities
Marieke C. J. Dekker, Toumany Coulibaly, Soraya Bardien, Owen A. Ross, Jonathan Carr, Morenikeji Komolafe
Frontiers in Neurology.2020;[Epub] CrossRef - Parkinson's disease in Nigeria: A review of published studies and recommendations for future research
Oluwafemi G. Oluwole, Helena Kuivaniemi, Jonathan A. Carr, Owen A. Ross, Matthew O.B. Olaogun, Soraya Bardien, Morenikeji A. Komolafe
Parkinsonism & Related Disorders.2019; 62: 36. CrossRef - Predictive Factors of Concerns about Falling in People with Parkinson’s Disease: A 3-Year Longitudinal Study
Magnus Lindh-Rengifo, Stina B. Jonasson, Niklas Mattsson, Susann Ullén, Maria H. Nilsson
Parkinson's Disease.2019; 2019: 1. CrossRef
- Concept Mapping to Define Components for an Occupation-Based Intervention for Parkinson’s Disease and Anxiety
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