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- Maladaptive Reward-Learning and Impulse Control Disorders in Patients with Parkinson’s Disease: A Clinical Overview and Pathophysiology Update
- Jee-Young Lee, Beom Seok Jeon
- J Mov Disord. 2014;7(2):67-76. Published online October 30, 2014
- DOI: https://doi.org/10.14802/jmd.14010
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- 124 Download
- 9 Web of Science
- 9 Crossref
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Abstract
PDF - Impulse control disorders (ICD) in Parkinson’s disease (PD) are a disabling non-motor symptom with frequencies of 13–35% among patients receiving dopamine replacement therapy. ICD in PD is strongly associated with dopaminergic drug use, especially non-ergot dopamine agonists (DA). However, individual susceptibility and disease-related neural changes are also important contributors to the development of ICD. Discrepancies between nigrostriatal and mesolimbic dopaminergic degeneration and non-physiological administration of dopaminergic drugs may induce abnormal ’hyperstimulation’ of the mesolimbic system, which alters reward-learning behaviors in PD patients. In addition, DA can make patients more impulsive during decision-making and seek risk-taking behaviors. DA intake is also related to the biased representation of rewards. Ultimately, loss of negative feedback control due to dysfunctional frontostriatal connections is necessary for the establishment of ICD in PD. The subsequent behavioral and neural changes are affected by PD treatment and disease progression; thus, proper treatment guidelines for physicians are needed to prevent the development of ICD. Future studies aimed at producing novel therapeutics to control the risk factors for ICD or treat ICD behaviors in PD are warranted. This review summarizes recent advances from epidemiological and pathophysiological studies on ICD in PD. Management principles and limitations of current therapeutics are briefly discussed.
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Citations
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- Quantitative and qualitative sex difference in habenula-induced inhibition of midbrain dopamine neurons in the rat
Dana Bell, Vaughn J. Waldron, P. Leon Brown
Frontiers in Behavioral Neuroscience.2023;[Epub] CrossRef - No Higher Risk-Seeking Tendencies or Altered Self-Estimation in a Social Decision-Making Task in Patients with Parkinson’s Disease
Alexandra C. Zapf, Ann-Kristin Folkerts, Larissa Kahler, Alfons Schnitzler, Paul Reker, Michael T. Barbe, Esther Florin, Elke Kalbe
Journal of Parkinson's Disease.2022; 12(3): 1045. CrossRef - Reckless Generosity, Parkinson's Disease and Dopamine: A Case Series and Literature Review
Deborah Amstutz, Joan Philipp Michelis, Ines Debove, Marie Elise Maradan‐Gachet, Martin Lenard Lachenmayer, Julia Muellner, Kyrill Schwegler, Paul Krack
Movement Disorders Clinical Practice.2021; 8(3): 469. CrossRef - Behavioural and trait changes in parkinsonian patients with impulse control disorder after switching from dopamine agonist to levodopa therapy: results of REIN-PD trial
Jee-Young Lee, Beomseok Jeon, Seong-Beom Koh, Won Tae Yoon, Ho-Won Lee, Oh Dae Kwon, Jae Woo Kim, Jong-Min Kim, Hyeo-Il Ma, Hee-Tae Kim, Jong Sam Baik, Jinwhan Cho
Journal of Neurology, Neurosurgery & Psychiatry.2019; 90(1): 30. CrossRef - Impulse control disorders in Parkinson disease: A cross-sectional study in Morocco
H. El Otmani, F.Z. Mouni, Z. Abdulhakeem, Z. Attar, L. Rashad, I. Saali, B. El Moutawakil, M.A. Rafai, I. Slassi, S. Nadifi
Revue Neurologique.2019; 175(4): 233. CrossRef - Dopamine Agonists and Impulse Control Disorders: A Complex Association
Marie Grall-Bronnec, Caroline Victorri-Vigneau, Yann Donnio, Juliette Leboucher, Morgane Rousselet, Elsa Thiabaud, Nicolas Zreika, Pascal Derkinderen, Gaëlle Challet-Bouju
Drug Safety.2018; 41(1): 19. CrossRef - Mesocorticolimbic hemodynamic response in Parkinson's disease patients with compulsive behaviors
Daniel O. Claassen, Adam J. Stark, Charis A. Spears, Kalen J. Petersen, Nelleke C. van Wouwe, Robert M. Kessler, David H. Zald, Manus J. Donahue
Movement Disorders.2017; 32(11): 1574. CrossRef - Stress-Induced Executive Dysfunction in GDNF-Deficient Mice, A Mouse Model of Parkinsonism
Mona Buhusi, Kaitlin Olsen, Benjamin Z. Yang, Catalin V. Buhusi
Frontiers in Behavioral Neuroscience.2016;[Epub] CrossRef - Patients’ Reluctance to undergo Deep Brain Stimulation for Parkinson’s Disease
Mi-Ryoung Kim, Ji Young Yun, Beomseok Jeon, Yong Hoon Lim, Kyung Ran Kim, Hui-Jun Yang, Sun Ha Paek
Parkinsonism & Related Disorders.2015;[Epub] CrossRef
- Quantitative and qualitative sex difference in habenula-induced inhibition of midbrain dopamine neurons in the rat
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