Huntington’s disease (HD) is a neurodegenerative disorder characterized by motor, behavioral, and cognitive impairments and significant impacts on patient quality of life. This evidence-based review, conducted by the Korean Huntington Disease Society task force, systematically examines current pharmacological and nonpharmacological interventions for symptomatic management of HD. Following PRISMA guidelines, databases were searched for studies up to August 2022 that focused on 23 symptoms across four domains: motor, neuropsychological, cognition, and others. This review provides a comprehensive and systematic approach to the management of HD, highlighting the need for more high-quality clinical trials to develop robust evidence-based guidelines.
Citations
Citations to this article as recorded by
A review of treatment methods for movement disorders Mahdi Khezri, Shakiba Afsar Behavioural Brain Research.2026; 500: 115979. CrossRef
Revisiting an immunoneuropsychiatry classic: Sydenham’s chorea Antonio L. Teixeira, Debora P. Maia, Maria Carmo Pereira Nunes, Gabriel A. de Erausquin, Cristian P. Zeni, Aline S. Miranda Expert Review of Clinical Immunology.2026; 22(3): 263. CrossRef
A Practical Guide for Diagnostic Investigations and Special Considerations in Patients With Huntington’s Disease in Korea Jangsup Moon, Eungseok Oh, Minkyeong Kim, Ryul Kim, Dallah Yoo, Chaewon Shin, Jee-Young Lee, Jong-Min Kim, Seong-Beom Koh, Manho Kim, Beomseok Jeon Journal of Movement Disorders.2025; 18(1): 17. CrossRef
Psychosis in Huntington's disease: A systematic review of case reports Aliu Opeyemi Yakubu, Oluwakemi Eunice Olalude, Olorungbami Kolade Anifalaje, Moses Gregory Effiong, Francess Oluwaferanmi Adeyemi, Maryam Abubakar General Hospital Psychiatry.2025; 97: 82. CrossRef