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Original Article
- Reduced Neck Muscle Strength and Altered Muscle Mechanical Properties in Cervical Dystonia Following Botulinum Neurotoxin Injections: A Prospective Study
- Sirpa Mustalampi, Jari Ylinen, Katariina Korniloff, Adam Weir, Arja H?kkinen
- J Mov Disord. 2016;9(1):44-49. Published online January 25, 2016
- DOI: https://doi.org/10.14802/jmd.15035
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- 3 Web of Science
- 2 Crossref
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Abstract
PDF - Objective
To evaluate changes in the strength and mechanical properties of neck muscles and disability in patients with cervical dystonia (CD) during a 12-week period following botulinum neurotoxin (BoNT) injections.
Methods
Eight patients with CD volunteered for this prospective clinical cohort study. Patients had received BoNT injections regularly in neck muscles at three-month intervals for several years. Maximal isometric neck strength was measured by a dynamometer, and the mechanical properties of the splenius capitis were evaluated using two myotonometers. Clinical assessment was performed using the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) before and at 2, 4, 8, and 12 weeks after the BoNT injections.
Results
Mean maximal isometric neck strength at two weeks after the BoNT injections decreased by 28% in extension, 25% in rotation of the affected side and 17% in flexion. At four weeks, muscle stiffness of the affected side decreased by 17% and tension decreased by 6%. At eight weeks, the muscle elasticity on the affected side increased by 12%. At two weeks after the BoNT injections, the TWSTRS-severity and TWSTRS-total scores decreased by 4.3 and 6.4, respectively. The strength, muscle mechanical properties and TWSTRS scores returned to baseline values at 12 weeks.
Conclusions
Although maximal neck strength and muscle tone decreased after BoNT injections, the disability improved. The changes observed after BoNT injections were temporary and returned to pre-injection levels within twelve weeks. Despite having a possible negative effect on function and decreasing neck strength, the BoNT injections improved the patients reported disability. -
Citations
Citations to this article as recorded by
- Paravertebral Muscle Mechanical Properties and Spinal Range of Motion in Patients with Acute Neck or Low Back Pain: A Case-Control Study
Sandra Alcaraz-Clariana, Lourdes García-Luque, Juan Luis Garrido-Castro, César Fernández-de-las-Peñas, Cristina Carmona-Pérez, Daiana Priscila Rodrigues-de-Souza, Francisco Alburquerque-Sendín
Diagnostics.2021; 11(2): 352. CrossRef - Paravertebral Muscle Mechanical Properties in Patients with Axial Spondyloarthritis or Low Back Pain: A Case-Control Study
Sandra Alcaraz-Clariana, Lourdes García-Luque, Juan Luis Garrido-Castro, I. Concepción Aranda-Valera, Lourdes Ladehesa-Pineda, María Ángeles Puche-Larrubia, Cristina Carmona-Pérez, Daiana Priscila Rodrigues-de-Souza, Francisco Alburquerque-Sendín
Diagnostics.2021; 11(10): 1898. CrossRef
- Paravertebral Muscle Mechanical Properties and Spinal Range of Motion in Patients with Acute Neck or Low Back Pain: A Case-Control Study
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