Skip Navigation
Skip to contents

JMD : Journal of Movement Disorders

OPEN ACCESS
SEARCH
Search

Search

Page Path
HOME > Search
2 "Impulsivity"
Filter
Filter
Article category
Keywords
Publication year
Authors
Funded articles
Original Article
The Impact of Impulsivity on Quality of Life in Early Drug-Naïve Parkinson’s Disease Patients
Dong-Woo Ryu, Joong-Seok Kim, Sang-Won Yoo, Yoon-Sang Oh, Kwang-Soo Lee
J Mov Disord. 2019;12(3):172-176.   Published online August 9, 2019
DOI: https://doi.org/10.14802/jmd.19004
Correction in: J Mov Disord 2021;14(2):176
  • 3,899 View
  • 100 Download
  • 4 Citations
AbstractAbstract PDF
Objective
Impulse control disorders (ICDs) in Parkinson’s disease (PD) are mostly related to dopamine replacement therapy (DRT); however, drug-naïve PD patients have also frequently experienced impulsivity. This phenomenon makes clinicians hesitate treating patients with DRT. In this study, we assessed the effect of impulsivity on quality of life (QOL) in drug-naïve PD patients.
Methods
Two hundred three newly diagnosed, nonmedicated PD patients were enrolled, and they received structured clinical interviews, physical examinations and validated questionnaires to evaluate motor and nonmotor symptoms and QOL. Impulsivity was evaluated using the Questionnaire for Impulsive-Compulsive Disorders in Parkinson’s Disease-Rating Scale (QUIP-RS).
Results
Thirty-eight patients (18.7%) had impulsivity with QUIP-RS scores ≥ 1 and 4 patients (2.0%) were diagnosed with combined ICDs. Motor and nonmotor symptoms were significantly correlated with the Parkinson’s Disease Questionnaire-39 summary index. Female sex and QUIP-RS scores were also correlated with QOL in drug-naïve PD patients.
Conclusion
The results of the present study showed that impulsivity negatively influences QOL in early drug-naïve PD patients. In addition, more severe motor and nonmotor symptoms were also associated with lower QOL. Such findings complicate treatment but provide valuable information for managing early PD.

Citations

Citations to this article as recorded by  
  • Neuropsychiatric Symptoms in Parkinson's Disease After Subthalamic Nucleus Deep Brain Stimulation
    Weibing Liu, Tatsuya Yamamoto, Yoshitaka Yamanaka, Masato Asahina, Tomoyuki Uchiyama, Shigeki Hirano, Keisuke Shimizu, Yoshinori Higuchi, Satoshi Kuwabara
    Frontiers in Neurology.2021;[Epub]     CrossRef
  • Dopamine genetic risk score predicts impulse control behaviors in Parkinson’s disease
    Alison Hall, Samuel R. Weaver, Lindsey J. Compton, Winston D. Byblow, Ned Jenkinson, Hayley J. MacDonald
    Clinical Parkinsonism & Related Disorders.2021; 5: 100113.     CrossRef
  • A Review of the Concept of Impulsivity
    Mohammed Munther Al-Hammouri, Jehad A. Rababah, Celeste Shawler
    Advances in Nursing Science.2021; 44(4): 357.     CrossRef
  • Assessment of therapeutic strategies for management of impulse control disorder in Parkinson’s disease
    Mayela Rodríguez-Violante, Yazmín Ríos-Solís, Oscar Esquivel-Zapata, Fanny Herrera, Susana López-Alamillo, Cynthia Sarabia-Tapia, Amin Cervantes-Arriaga
    Arquivos de Neuro-Psiquiatria.2021; 79(11): 989.     CrossRef
Review Article
Maladaptive Reward-Learning and Impulse Control Disorders in Patients with Parkinson’s Disease: A Clinical Overview and Pathophysiology Update
Jee-Young Lee, Beom Seok Jeon
J Mov Disord. 2014;7(2):67-76.   Published online October 30, 2014
DOI: https://doi.org/10.14802/jmd.14010
  • 36,775 View
  • 120 Download
  • 8 Citations
AbstractAbstract PDF
Impulse control disorders (ICD) in Parkinson’s disease (PD) are a disabling non-motor symptom with frequencies of 13–35% among patients receiving dopamine replacement therapy. ICD in PD is strongly associated with dopaminergic drug use, especially non-ergot dopamine agonists (DA). However, individual susceptibility and disease-related neural changes are also important contributors to the development of ICD. Discrepancies between nigrostriatal and mesolimbic dopaminergic degeneration and non-physiological administration of dopaminergic drugs may induce abnormal ’hyperstimulation’ of the mesolimbic system, which alters reward-learning behaviors in PD patients. In addition, DA can make patients more impulsive during decision-making and seek risk-taking behaviors. DA intake is also related to the biased representation of rewards. Ultimately, loss of negative feedback control due to dysfunctional frontostriatal connections is necessary for the establishment of ICD in PD. The subsequent behavioral and neural changes are affected by PD treatment and disease progression; thus, proper treatment guidelines for physicians are needed to prevent the development of ICD. Future studies aimed at producing novel therapeutics to control the risk factors for ICD or treat ICD behaviors in PD are warranted. This review summarizes recent advances from epidemiological and pathophysiological studies on ICD in PD. Management principles and limitations of current therapeutics are briefly discussed.

Citations

Citations to this article as recorded by  
  • No Higher Risk-Seeking Tendencies or Altered Self-Estimation in a Social Decision-Making Task in Patients with Parkinson’s Disease
    Alexandra C. Zapf, Ann-Kristin Folkerts, Larissa Kahler, Alfons Schnitzler, Paul Reker, Michael T. Barbe, Esther Florin, Elke Kalbe
    Journal of Parkinson's Disease.2022; 12(3): 1045.     CrossRef
  • Reckless Generosity, Parkinson's Disease and Dopamine: A Case Series and Literature Review
    Deborah Amstutz, Joan Philipp Michelis, Ines Debove, Marie Elise Maradan‐Gachet, Martin Lenard Lachenmayer, Julia Muellner, Kyrill Schwegler, Paul Krack
    Movement Disorders Clinical Practice.2021; 8(3): 469.     CrossRef
  • Behavioural and trait changes in parkinsonian patients with impulse control disorder after switching from dopamine agonist to levodopa therapy: results of REIN-PD trial
    Jee-Young Lee, Beomseok Jeon, Seong-Beom Koh, Won Tae Yoon, Ho-Won Lee, Oh Dae Kwon, Jae Woo Kim, Jong-Min Kim, Hyeo-Il Ma, Hee-Tae Kim, Jong Sam Baik, Jinwhan Cho
    Journal of Neurology, Neurosurgery & Psychiatry.2019; 90(1): 30.     CrossRef
  • Impulse control disorders in Parkinson disease: A cross-sectional study in Morocco
    H. El Otmani, F.Z. Mouni, Z. Abdulhakeem, Z. Attar, L. Rashad, I. Saali, B. El Moutawakil, M.A. Rafai, I. Slassi, S. Nadifi
    Revue Neurologique.2019; 175(4): 233.     CrossRef
  • Dopamine Agonists and Impulse Control Disorders: A Complex Association
    Marie Grall-Bronnec, Caroline Victorri-Vigneau, Yann Donnio, Juliette Leboucher, Morgane Rousselet, Elsa Thiabaud, Nicolas Zreika, Pascal Derkinderen, Gaëlle Challet-Bouju
    Drug Safety.2018; 41(1): 19.     CrossRef
  • Mesocorticolimbic hemodynamic response in Parkinson's disease patients with compulsive behaviors
    Daniel O. Claassen, Adam J. Stark, Charis A. Spears, Kalen J. Petersen, Nelleke C. van Wouwe, Robert M. Kessler, David H. Zald, Manus J. Donahue
    Movement Disorders.2017; 32(11): 1574.     CrossRef
  • Stress-Induced Executive Dysfunction in GDNF-Deficient Mice, A Mouse Model of Parkinsonism
    Mona Buhusi, Kaitlin Olsen, Benjamin Z. Yang, Catalin V. Buhusi
    Frontiers in Behavioral Neuroscience.2016;[Epub]     CrossRef
  • Patients’ Reluctance to undergo Deep Brain Stimulation for Parkinson’s Disease
    Mi-Ryoung Kim, Ji Young Yun, Beomseok Jeon, Yong Hoon Lim, Kyung Ran Kim, Hui-Jun Yang, Sun Ha Paek
    Parkinsonism & Related Disorders.2015;[Epub]     CrossRef

JMD : Journal of Movement Disorders