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Original Article
- Parkinson’s Disease, Impulsive-Compulsive Behaviors, and Health-Related Quality of Life
- Marie Grall-Bronnec, Audrey Verholleman, Caroline Victorri-Vigneau, Juliette Leboucher, Elsa Thiabaud, Jean-Benoit Hardouin, Benoit Schreck, Tiphaine Rouaud, Monica Roy, Pascal Derkinderen, Gaëlle Challet-Bouju
- J Mov Disord. 2024;17(1):82-88. Published online November 6, 2023
- DOI: https://doi.org/10.14802/jmd.23042
- 864 View
- 74 Download
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Abstract
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Supplementary Material - Objective
A large body of literature has examined the links between the use of dopamine replacement therapy (DRT) in Parkinson’s disease (PD) and the development of “impulsive-compulsive behaviors (ICBs).” Little is known regarding the link between the development of ICBs and health-related quality of life (HRQOL). We aimed to explore the factors that are associated with poorer HRQOL, especially in relation to DRT-induced ICBs, in a sample of PD patients.
Methods
This PARKADD (PARK: PARKinson’s disease; ADD: behavioral ADDictions) study was a prospective case‒control study initially designed to assess the factors associated with ICBs in PD patients. A prospective clinical follow-up was added, aiming to capture the long-term evolution of HRQOL in relation to ICBs occurring or worsening after the beginning of PD. We focused on sociodemographic and PD characteristics and the history or presence of ICBs. HRQOL was measured using the Parkinson’s Disease Questionnaire-8. A multivariate linear regression was performed to identify factors related to poorer HRQOL.
Results
A total of 169 patients were eligible for the follow-up study. The presence of an ICB, a higher levodopa equivalent daily dose (LEDD) and a longer PD duration were significantly associated with poorer HRQOL, with an interaction between LEDD and PD duration.
Conclusion
The presence of an ICB was related to poorer HRQOL and should be considered a crucial factor for the management of PD patients. Several studies were recently published that provide guidelines for the management of these patients, with recommendations based on two key principles: prevention and specific treatment.
Case Report
- Young-Onset Parkinson’s Disease with Impulse Control Disorder Due to Novel Variants of F-Box Only Protein 7
- Dallah Yoo, Ji-Hyun Choi, Jin-Hee Im, Man Jin Kim, Han-Joon Kim, Sung Sup Park, Beomseok Jeon
- J Mov Disord. 2020;13(3):225-228. Published online September 9, 2020
- DOI: https://doi.org/10.14802/jmd.20026
- 4,957 View
- 115 Download
- 3 Web of Science
- 3 Crossref
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Abstract
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- F-box only protein 7 (FBXO7) is a rare monogenic cause of hereditary Parkinson’s disease (PD) with an autosomal recessive mode of inheritance and a broad spectrum of clinical manifestations. Here, we report a de novo PD patient with onset at the age of 28 with novel compound heterozygous variants in the FBXO7 gene (c.1162C>T, p.Gln388X; c.80G>A, p.Arg27His). The clinical features of the patient were problematic impulse control disorder behaviors and pyromania, and pyramidal signs were negative. We describe the novel pathogenic variants of the FBXO7 gene with detailed clinical pictures to report the expanding genotypes and phenotypes of FBXO7-associated parkinsonism.
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Citations
Citations to this article as recorded by
- Study of an FBXO7 patient mutation reveals Fbxo7 and PI31 co‐regulate proteasomes and mitochondria
Sara Al Rawi, Lorna Simpson, Guðrún Agnarsdóttir, Neil Q. McDonald, Veronika Chernuha, Orly Elpeleg, Massimo Zeviani, Roger A. Barker, Ronen Spiegel, Heike Laman
The FEBS Journal.2024;[Epub] CrossRef - Loss of the parkinsonism‐associated protein FBXO7 in glutamatergic forebrain neurons in mice leads to abnormal motor behavior and synaptic defects
Jingbo Wang, Sabitha Joseph, Siv Vingill, Ekrem Dere, Lars Tatenhorst, Anja Ronnenberg, Paul Lingor, Christian Preisinger, Hannelore Ehrenreich, Jörg B. Schulz, Judith Stegmüller
Journal of Neurochemistry.2023; 167(2): 296. CrossRef - Nearly Abolished Dopamine Transporter Uptake in a Patient With a Novel FBXO7 Mutation
Eun Young Kim, Seon Young Kim, Youngduk Seo, Chaewon Shin
Journal of Movement Disorders.2022; 15(3): 269. CrossRef
- Study of an FBXO7 patient mutation reveals Fbxo7 and PI31 co‐regulate proteasomes and mitochondria
Original Article
- The Impact of Impulsivity on Quality of Life in Early Drug-Naïve Parkinson’s Disease Patients
- Dong-Woo Ryu, Joong-Seok Kim, Sang-Won Yoo, Yoon-Sang Oh, Kwang-Soo Lee
- J Mov Disord. 2019;12(3):172-176. Published online August 9, 2019
- DOI: https://doi.org/10.14802/jmd.19004
- Correction in: J Mov Disord 2021;14(2):176
- 5,270 View
- 107 Download
- 7 Web of Science
- 6 Crossref
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Abstract
PDF
- Objective
Impulse control disorders (ICDs) in Parkinson’s disease (PD) are mostly related to dopamine replacement therapy (DRT); however, drug-naïve PD patients have also frequently experienced impulsivity. This phenomenon makes clinicians hesitate treating patients with DRT. In this study, we assessed the effect of impulsivity on quality of life (QOL) in drug-naïve PD patients.
Methods
Two hundred three newly diagnosed, nonmedicated PD patients were enrolled, and they received structured clinical interviews, physical examinations and validated questionnaires to evaluate motor and nonmotor symptoms and QOL. Impulsivity was evaluated using the Questionnaire for Impulsive-Compulsive Disorders in Parkinson’s Disease-Rating Scale (QUIP-RS).
Results
Thirty-eight patients (18.7%) had impulsivity with QUIP-RS scores ≥ 1 and 4 patients (2.0%) were diagnosed with combined ICDs. Motor and nonmotor symptoms were significantly correlated with the Parkinson’s Disease Questionnaire-39 summary index. Female sex and QUIP-RS scores were also correlated with QOL in drug-naïve PD patients.
Conclusion
The results of the present study showed that impulsivity negatively influences QOL in early drug-naïve PD patients. In addition, more severe motor and nonmotor symptoms were also associated with lower QOL. Such findings complicate treatment but provide valuable information for managing early PD. -
Citations
Citations to this article as recorded by- Frequency of Impulsive-Compulsive Behavior and Associated Psychological Factors in Parkinson’s Disease: Lack of Control or Too Much of It?
Alexandros Kapsomenakis, Dimitrios Kasselimis, Emily Vaniotis, Anastasia Bougea, Christos Koros, Athina Maria Simitsi, Leonidas Stefanis, Constantin Potagas
Medicina.2023; 59(11): 1942. CrossRef - Locus Coeruleus Integrity Is Linked to Response Inhibition Deficits in Parkinson's Disease and Progressive Supranuclear Palsy
Rong Ye, Frank H. Hezemans, Claire O'Callaghan, Kamen A. Tsvetanov, Catarina Rua, P. Simon Jones, Negin Holland, Maura Malpetti, Alexander G. Murley, Roger A. Barker, Caroline H. Williams-Gray, Trevor W. Robbins, Luca Passamonti, James B. Rowe
The Journal of Neuroscience.2023; 43(42): 7028. CrossRef - Neuropsychiatric Symptoms in Parkinson's Disease After Subthalamic Nucleus Deep Brain Stimulation
Weibing Liu, Tatsuya Yamamoto, Yoshitaka Yamanaka, Masato Asahina, Tomoyuki Uchiyama, Shigeki Hirano, Keisuke Shimizu, Yoshinori Higuchi, Satoshi Kuwabara
Frontiers in Neurology.2021;[Epub] CrossRef - Dopamine genetic risk score predicts impulse control behaviors in Parkinson’s disease
Alison Hall, Samuel R. Weaver, Lindsey J. Compton, Winston D. Byblow, Ned Jenkinson, Hayley J. MacDonald
Clinical Parkinsonism & Related Disorders.2021; 5: 100113. CrossRef - A Review of the Concept of Impulsivity
Mohammed Munther Al-Hammouri, Jehad A. Rababah, Celeste Shawler
Advances in Nursing Science.2021; 44(4): 357. CrossRef - Assessment of therapeutic strategies for management of impulse control disorder in Parkinson’s disease
Mayela Rodríguez-Violante, Yazmín Ríos-Solís, Oscar Esquivel-Zapata, Fanny Herrera, Susana López-Alamillo, Cynthia Sarabia-Tapia, Amin Cervantes-Arriaga
Arquivos de Neuro-Psiquiatria.2021; 79(11): 989. CrossRef
- Frequency of Impulsive-Compulsive Behavior and Associated Psychological Factors in Parkinson’s Disease: Lack of Control or Too Much of It?
Review Article
- Maladaptive Reward-Learning and Impulse Control Disorders in Patients with Parkinson’s Disease: A Clinical Overview and Pathophysiology Update
- Jee-Young Lee, Beom Seok Jeon
- J Mov Disord. 2014;7(2):67-76. Published online October 30, 2014
- DOI: https://doi.org/10.14802/jmd.14010
- 37,933 View
- 124 Download
- 9 Web of Science
- 9 Crossref
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Abstract
PDF
- Impulse control disorders (ICD) in Parkinson’s disease (PD) are a disabling non-motor symptom with frequencies of 13–35% among patients receiving dopamine replacement therapy. ICD in PD is strongly associated with dopaminergic drug use, especially non-ergot dopamine agonists (DA). However, individual susceptibility and disease-related neural changes are also important contributors to the development of ICD. Discrepancies between nigrostriatal and mesolimbic dopaminergic degeneration and non-physiological administration of dopaminergic drugs may induce abnormal ’hyperstimulation’ of the mesolimbic system, which alters reward-learning behaviors in PD patients. In addition, DA can make patients more impulsive during decision-making and seek risk-taking behaviors. DA intake is also related to the biased representation of rewards. Ultimately, loss of negative feedback control due to dysfunctional frontostriatal connections is necessary for the establishment of ICD in PD. The subsequent behavioral and neural changes are affected by PD treatment and disease progression; thus, proper treatment guidelines for physicians are needed to prevent the development of ICD. Future studies aimed at producing novel therapeutics to control the risk factors for ICD or treat ICD behaviors in PD are warranted. This review summarizes recent advances from epidemiological and pathophysiological studies on ICD in PD. Management principles and limitations of current therapeutics are briefly discussed.
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Citations
Citations to this article as recorded by- Quantitative and qualitative sex difference in habenula-induced inhibition of midbrain dopamine neurons in the rat
Dana Bell, Vaughn J. Waldron, P. Leon Brown
Frontiers in Behavioral Neuroscience.2023;[Epub] CrossRef - No Higher Risk-Seeking Tendencies or Altered Self-Estimation in a Social Decision-Making Task in Patients with Parkinson’s Disease
Alexandra C. Zapf, Ann-Kristin Folkerts, Larissa Kahler, Alfons Schnitzler, Paul Reker, Michael T. Barbe, Esther Florin, Elke Kalbe
Journal of Parkinson's Disease.2022; 12(3): 1045. CrossRef - Reckless Generosity, Parkinson's Disease and Dopamine: A Case Series and Literature Review
Deborah Amstutz, Joan Philipp Michelis, Ines Debove, Marie Elise Maradan‐Gachet, Martin Lenard Lachenmayer, Julia Muellner, Kyrill Schwegler, Paul Krack
Movement Disorders Clinical Practice.2021; 8(3): 469. CrossRef - Behavioural and trait changes in parkinsonian patients with impulse control disorder after switching from dopamine agonist to levodopa therapy: results of REIN-PD trial
Jee-Young Lee, Beomseok Jeon, Seong-Beom Koh, Won Tae Yoon, Ho-Won Lee, Oh Dae Kwon, Jae Woo Kim, Jong-Min Kim, Hyeo-Il Ma, Hee-Tae Kim, Jong Sam Baik, Jinwhan Cho
Journal of Neurology, Neurosurgery & Psychiatry.2019; 90(1): 30. CrossRef - Impulse control disorders in Parkinson disease: A cross-sectional study in Morocco
H. El Otmani, F.Z. Mouni, Z. Abdulhakeem, Z. Attar, L. Rashad, I. Saali, B. El Moutawakil, M.A. Rafai, I. Slassi, S. Nadifi
Revue Neurologique.2019; 175(4): 233. CrossRef - Dopamine Agonists and Impulse Control Disorders: A Complex Association
Marie Grall-Bronnec, Caroline Victorri-Vigneau, Yann Donnio, Juliette Leboucher, Morgane Rousselet, Elsa Thiabaud, Nicolas Zreika, Pascal Derkinderen, Gaëlle Challet-Bouju
Drug Safety.2018; 41(1): 19. CrossRef - Mesocorticolimbic hemodynamic response in Parkinson's disease patients with compulsive behaviors
Daniel O. Claassen, Adam J. Stark, Charis A. Spears, Kalen J. Petersen, Nelleke C. van Wouwe, Robert M. Kessler, David H. Zald, Manus J. Donahue
Movement Disorders.2017; 32(11): 1574. CrossRef - Stress-Induced Executive Dysfunction in GDNF-Deficient Mice, A Mouse Model of Parkinsonism
Mona Buhusi, Kaitlin Olsen, Benjamin Z. Yang, Catalin V. Buhusi
Frontiers in Behavioral Neuroscience.2016;[Epub] CrossRef - Patients’ Reluctance to undergo Deep Brain Stimulation for Parkinson’s Disease
Mi-Ryoung Kim, Ji Young Yun, Beomseok Jeon, Yong Hoon Lim, Kyung Ran Kim, Hui-Jun Yang, Sun Ha Paek
Parkinsonism & Related Disorders.2015;[Epub] CrossRef
- Quantitative and qualitative sex difference in habenula-induced inhibition of midbrain dopamine neurons in the rat
Case Report
- Dopaminergic Medication-Related Repetitive Behaviors in Parkinson’s Disease
- Jong Sam Baik, Sang Won Han, Jeong Yeon Kim, Jae Hyeon Park
- J Mov Disord. 2008;1(2):101-103.
- DOI: https://doi.org/10.14802/jmd.08020
- 15,751 View
- 140 Download
- 1 Crossref
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Abstract
PDF
A set of impulse control and repetitive behaviors presumed to be related to dopaminergic medications has been recognized in Parkinson’s disease (PD). A 68-year-old man presented with compulsive gathering of new towels for 8 months after increasing his medication dosage. After we reduced a dose of Sinemet® and ropinirole as before, and added amantadine, his repetitive behavior was gone and dyskinesia was improved.
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Citations
Citations to this article as recorded by- A Case of Dopamine Dysregulation Syndrome and Repetitive Behavior Caused by Levodopa in Parkinson's Disease
So Young Huh, Min Jeong Kim
Journal of the Korean Geriatrics Society.2010; 14(3): 171. CrossRef
- A Case of Dopamine Dysregulation Syndrome and Repetitive Behavior Caused by Levodopa in Parkinson's Disease
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