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1 "Glial fibrillary acidic protein (GFAP)"
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Case Report
Parainfectious Anti-Glial Fibrillary Acidic Protein-Associated Meningoencephalitis
Jae Young Joo, Dallah Yoo, Tae-Beom Ahn
J Mov Disord. 2022;15(1):66-70.   Published online November 25, 2021
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AbstractAbstract PDFSupplementary Material
Movement disorders associated with glial fibrillary acidic protein (GFAP) autoantibodies have rarely been reported as ataxia or tremors. A 32-year-old man with headache and fever, initially diagnosed with viral meningoencephalitis, showed gradual improvement with empirical treatment. Two weeks after the illness, he suddenly developed orofacial, tongue, and neck dyskinesia accompanied by oculomotor abnormalities, which developed into severe generalized choreoballism. Brain magnetic resonance imaging (fluid-attenuated inversion recovery) showed signal hyperintensities in the bilateral globus pallidus interna. The clinical picture suggested an acute inflammatory trigger of secondary autoimmune encephalitis. The autoimmune antibody test was positive for GFAP, with the strongest reactivity in the cerebrospinal fluid (CSF) before treatment and decreased reactivity in serial CSF examinations during immunotherapy. Dyskinesia gradually improved to the extent that it could be controlled with only oral medications. This patient presented with parainfectious GFAP meningoencephalitis with distinctive clinical features and imaging findings.


Citations to this article as recorded by  
  • Relapsing Autoimmune GFAP Astrocytopathy: Case Report
    Ekaterina O. Chekanova, Аlla А. Shabalina, Taras O. Simaniv, Rodion N. Konovalov, Larisa A. Dobrynina, Lyudmila A. Kalashnikova, Maria V. Gubanova, Maria N. Zakharova
    Annals of Clinical and Experimental Neurology.2024; 17(4): 89.     CrossRef
  • Comment on “Parainfectious Anti-Glial Fibrillary Acidic Protein-Associated Meningoencephalitis”
    Byoung June Ahn, Kyum-Yil Kwon
    Journal of Movement Disorders.2022; 15(2): 187.     CrossRef
  • Re: Comment on “Parainfectious Anti-Glial Fibrillary Acidic Protein-Associated Meningoencephalitis”
    Dallah Yoo, Tae-Beom Ahn
    Journal of Movement Disorders.2022; 15(2): 189.     CrossRef

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