Journal of Movement Disorders

Review Article

Parkinson’s Disease in Sub-Saharan Africa: A Review of Epidemiology, Genetics and Access to Care: Uduak Williams, Oliver Bandmann, Richard Walker; J Mov Disord. 2018;11(2):53-64. Published online May 30, 2018; DOI: https://doi.org/10.14802/jmd.17028

15,264 View
232 Download
36 Web of Science
37 Crossref

A low prevalence of Parkinson’s disease (PD) has been reported in the Sub-Saharan Africa (SSA) region. The genetic causes and clinical features of PD in this region have been poorly described. Very few reports have examined the availability and access to evidence-based quality care for people living with PD in this region. We reviewed all publications focusing on idiopathic PD from SSA published up to May 2016 and observed a prevalence of PD ranging from 7/100,000 in Ethiopia to 67/100,000 in Nigeria. The most recent community-based study reported a mean age at onset of 69.4 years. The infrequent occurrence of mutations in established PD genes was also observed in the region. Treatments were non-existent or at best irregular. Additionally, there is a lack of well-trained medical personnel and multidisciplinary teams in most countries in this region. Drugs for treating PD are either not available or unaffordable. Large-scale genetic and epidemiological studies are therefore needed in SSA to provide further insights into the roles of genetics and other etiological factors in the pathogenesis of PD. The quality of care also requires urgent improvement to meet the basic level of care required by PD patients.

Citations

Citations to this article as recorded by

Delivery of Allied Health Therapies to People with Parkinson’s Disease in Africa
Roberto Cilia, Marieke C.J. Dekker, Esther Cubo, Mary W. Agoriwo, Elke Kalbe, Bastiaan R. Bloem, Lorraine V. Kalia, Alice Nieuwboer
Journal of Parkinson's Disease.2024; 14(s1): S227. CrossRef
The Role of Diet in Parkinson’s Disease
Kira N. Tosefsky, Julie Zhu, Yolanda N. Wang, Joyce S.T. Lam, Amanda Cammalleri, Silke Appel-Cresswell, Elke Kalbe, Bastiaan R. Bloem, Lorraine V. Kalia, Alice Nieuwboer
Journal of Parkinson's Disease.2024; 14(s1): S21. CrossRef
Advancing genetic testing for neurological disorders in Tanzania: importance, challenges, and strategies for implementation
Mohamed Zahir Alimohamed, Angela Augustine Siima, Mohamed Manji
Frontiers in Neuroscience.2024;[Epub] CrossRef
Epidemiology of Parkinson’s Disease: An Update
Juan R Deliz, Caroline M. Tanner, Paulina Gonzalez-Latapi
Current Neurology and Neuroscience Reports.2024; 24(6): 163. CrossRef
Spondias mombin flavonoids showed super-binder ability with downstream molecular targets of Parkinson's disease: A structural study
John A. Olanrewaju, Leviticus O. Arietarhire, Oladimeji E. Soremekun, Ezekiel A. Olugbogi, Toluwanimi O. Afolabi, Precious O. Aribisala, Pelumi E. Alege, Abayomi O. Sodipo, Babatunji E. Oyinloye, Olaposi I. Omotuyi
Informatics in Medicine Unlocked.2024; 49: 101543. CrossRef
Breaking barriers in Parkinson’s care: the multidisciplinary team approach
Zvezdan Pirtošek
Journal of Neural Transmission.2024; 131(11): 1349. CrossRef
Structure and process of Parkinson's disease rehabilitation in the southern sector of Ghana: A cross‐sectional survey
Mary W. Agoriwo, Conran Joseph, Erika Franzén, Marianne Unger
Journal of Evaluation in Clinical Practice.2024;[Epub] CrossRef
Phytoconstituents of Datura metel extract improved motor coordination in haloperidol-induced cataleptic mice: Dual-target molecular docking and behavioural studies
Bilqis Abiola Lawal, Yusuf Oloruntoyin Ayipo, Abisola Oyindamola Adekunle, Mohammed Otuofu Amali, Umar Muhammad Badeggi, Waleed A. Alananzeh, Mohd Nizam Mordi
Journal of Ethnopharmacology.2023; 300: 115753. CrossRef
Particularités de la Maladie de Parkinson de la personne âgée : expérience du service de gériatrie de Fann à Dakar (Sénégal)
A. Sall, M. Ba, R. Djajheté, D. Ba, S. Zaki, M. Coumé
NPG Neurologie - Psychiatrie - Gériatrie.2023; 23(134): 85. CrossRef
The Gaps and Prospects of Movement Disorders Education and Research in Africa: A Continental Survey
Eman Hamid, Kigocha Okengo, Biniyam A. Ayele, Daniel Gams Massi, Samia Ben Sassi, Houyam Tibar, Sarah Misbah El‐Sadig, Soulaimane Mahoui, Julien Razafimahefa, Ange Eric Kouame‐Assouan, Djibrilla Ben‐Adji, Lengane Y.T. Modeste, Muhyadin Hassan Mohamed, Nes
Movement Disorders.2023; 38(2): 178. CrossRef
Transforming Parkinson's Care in Africa (TraPCAf): protocol for a multimethodology National Institute for Health and Care Research Global Health Research Group project
R. Walker, N. Fothergill-Misbah, S. Kariuki, O. Ojo, R. Cilia, M. C. J. Dekker, O. Agabi, A. Akpalu, F. Amod, M. Breckons, M. Cham, S. Del Din, C. Dotchin, S. Guggsa, J. Kwasa, D. Mushi, F. O. Nwaokorie, T. Park, L. Rochester, J. Rogathi, F. S. Sarfo, A.
BMC Neurology.2023;[Epub] CrossRef
Exploring the levodopa-paradox of freezing of gait in dopaminergic medication-naïve Parkinson’s disease populations
Jamie A. F. Jansen, Tamine T. C. Capato, Sirwan K. L. Darweesh, Egberto R. Barbosa, Rogier Donders, Bastiaan R. Bloem, Jorik Nonnekes
npj Parkinson's Disease.2023;[Epub] CrossRef
The intestinal luminal sources of α-synuclein: a gastroenterologist perspective
Aaron Lerner
Nutrition Reviews.2022; 80(2): 282. CrossRef
Surveying Global Availability of Parkinson’s Disease Treatment
Zhao H.K. Goh, Julia L.Y. Cheong, Connie Marras, Caroline M. Tanner, Meike Kasten, Amos D. Korczyn, Lana Chahine, Raymond Lo, Alastair J. Noyce
Journal of Parkinson's Disease.2022; 12(3): 1023. CrossRef
Current Status of Next-Generation Sequencing Approaches for Candidate Gene Discovery in Familial Parkinson´s Disease
Nikita Simone Pillay, Owen A. Ross, Alan Christoffels, Soraya Bardien
Frontiers in Genetics.2022;[Epub] CrossRef
Utility of 18F FDG-PET in Parkinsonism in an African population
Ferzana Hassan Amod, Ahmed Iqbal Bhigjee, Nozipho Nyakale
eNeurologicalSci.2022; 27: 100399. CrossRef
A Narrative Review of Specialist Parkinson’s Nurses: Evolution, Evidence and Expectation
Emma Tenison, Alice James, Louise Ebenezer, Emily J. Henderson
Geriatrics.2022; 7(2): 46. CrossRef
Treatment with bark extracts of Voacanga africana attenuates motor coordination deficit, depressive-like behavior and microglial reaction, in a mouse model of early Parkinson's disease
Salimata Diagne Houndjo, Christophe Melon, Pascal Salin, Abdoulaye Samb, Fatou Bintou Sarr, Lydia Kerkerian-Le Goff, Sylviane Lortet
Phytomedicine Plus.2022; 2(3): 100297. CrossRef
Polygenic risk prediction and SNCA haplotype analysis in a Latino Parkinson's disease cohort
Douglas P. Loesch, Andrea R.V.R. Horimoto, Elif Irem Sarihan, Miguel Inca-Martinez, Emily Mason, Mario Cornejo-Olivas, Luis Torres, Pilar Mazzetti, Carlos Cosentino, Elison Sarapura-Castro, Andrea Rivera-Valdivia, Angel C. Medina, Elena Dieguez, Victor Ra
Parkinsonism & Related Disorders.2022; 102: 7. CrossRef
The impact of COVID‐19 on patients with neurological disorders and their access to healthcare in Africa: A review of the literature
Olivier Uwishema, Kristian Steen Frederiksen, Inês F. Silva Correia, Ashraf Mahmoud, Helen Onyeaka, Burhan Dost
Brain and Behavior.2022;[Epub] CrossRef
Perspective: Low Risk of Parkinson's Disease in Quasi-Vegan Cultures May Reflect GCN2-Mediated Upregulation of Parkin
Mark F McCarty, Aaron Lerner
Advances in Nutrition.2021; 12(2): 355. CrossRef
A Rapid Motor Task-Based Screening Tool for Parkinsonism in Community-Based Studies
Wendy W. Dlamini, Searles Nielsen, Mwiza Ushe, Gill Nelson, Brad A. Racette
Frontiers in Neurology.2021;[Epub] CrossRef
Parkinson disease-associated cognitive impairment
Dag Aarsland, Lucia Batzu, Glenda M. Halliday, Gert J. Geurtsen, Clive Ballard, K. Ray Chaudhuri, Daniel Weintraub
Nature Reviews Disease Primers.2021;[Epub] CrossRef
Probing the Pre-diagnostic Phase of Parkinson's Disease in Population-Based Studies
Lisanne J. Dommershuijsen, Agnita J. W. Boon, M. Kamran Ikram
Frontiers in Neurology.2021;[Epub] CrossRef
Medicinal plants for anti-neurodegenerative diseases in West Africa
Emmanuel Ayodeji Ayeni, Yuzhou Gong, Hao Yuan, Yikao Hu, Xiaolin Bai, Xun Liao
Journal of Ethnopharmacology.2021; : 114468. CrossRef
Mapping the Diverse and Inclusive Future of Parkinson’s Disease Genetics and Its Widespread Impact
Inas Elsayed, Alejandro Martinez-Carrasco, Mario Cornejo-Olivas, Sara Bandres-Ciga
Genes.2021; 12(11): 1681. CrossRef
Parkinson’s disease – a review of pathogenesis, recent advances in management, and challenges of care in sub-Saharan Africa
Akintomiwa I. Makanjuola, Funmilola T. Taiwo, Joseph O. Yaria, Rufus O. Akinyemi, Adesola Ogunniyi
Journal of Global Medicine.2021; : e35. CrossRef
Genetics of Parkinson's disease: An introspection of its journey towards precision medicine
Sara Bandres-Ciga, Monica Diez-Fairen, Jonggeol Jeff Kim, Andrew B. Singleton
Neurobiology of Disease.2020; 137: 104782. CrossRef
Targeted next-generation sequencing identifies novel variants in candidate genes for Parkinson’s disease in Black South African and Nigerian patients
Oluwafemi G. Oluwole, Helena Kuivaniemi, Shameemah Abrahams, William L. Haylett, Alvera A. Vorster, Carel J. van Heerden, Colin P. Kenyon, David L. Tabb, Michael B. Fawale, Taofiki A. Sunmonu, Abiodun Ajose, Matthew O. Olaogun, Anastasia C. Rossouw, Ludo
BMC Medical Genetics.2020;[Epub] CrossRef
Translation, Validation, Diagnostic Accuracy, and Reliability of Screening Questionnaire for Parkinsonism in Three African Countries
Ali Shalash, Njideka U. Okubadejo, Jacques Doumbe, Oluwadamilola O. Ojo, Eman Hamid, Callixte Kuate, Sara Calvo, Asmaa Helmi, Osigwe P. Agabi, Mohamed Essam, Laura Aguado, Hanan Elrassas, Tamer Roushdy, Caroline M. Tanner, Esther Cubo
Journal of Parkinson's Disease.2020; 10(3): 1113. CrossRef
Parkinson's Disease Research on the African Continent: Obstacles and Opportunities
Marieke C. J. Dekker, Toumany Coulibaly, Soraya Bardien, Owen A. Ross, Jonathan Carr, Morenikeji Komolafe
Frontiers in Neurology.2020;[Epub] CrossRef
Chitosan-Coated Hydroxypropylmethyl Cellulose Microparticles of Levodopa (and Carbidopa): In Vitro and Rat Model Kinetic Characteristics
Benedicta Obenewaa Dankyi, Seth Kwabena Amponsah, Grace Lovia Allotey-Babington, Ismaila Adams, Nana Aboadwe Goode, Henry Nettey
Current Therapeutic Research.2020; 93: 100612. CrossRef
Parkinson's disease in Nigeria: A review of published studies and recommendations for future research
Oluwafemi G. Oluwole, Helena Kuivaniemi, Jonathan A. Carr, Owen A. Ross, Matthew O.B. Olaogun, Soraya Bardien, Morenikeji A. Komolafe
Parkinsonism & Related Disorders.2019; 62: 36. CrossRef
Clinical series of Parkinson's disease in KwaZulu-Natal, South Africa: Retrospective chart review
Ferzana Hassan Amod, Ahmed Iqbal Bhigjee
Journal of the Neurological Sciences.2019; 401: 62. CrossRef
Frequency of the LRRK2 G2019S mutation in South African patients with Parkinson’s disease
Nicola du Toit, Riaan van Coller, David G. Anderson, Jonathan Carr, Soraya Bardien
neurogenetics.2019; 20(4): 215. CrossRef
Leucine rich repeat kinase 2 (LRRK2) GLY2019SER mutation is absent in a second cohort of Nigerian Africans with Parkinson disease
Njideka U. Okubadejo, Mie Rizig, Oluwadamilola O. Ojo, Hallgeir Jonvik, Olajumoke Oshinaike, Emmeline Brown, Henry Houlden, Hiroyoshi Ariga
PLOS ONE.2018; 13(12): e0207984. CrossRef
Motor Symptoms of Parkinson’s Disease – A Review Literature
Hilda Aboagyewaa Agyekum
Neurophysiology and Rehabilitation.2018; : 38. CrossRef

Original Articles

Ataxia with Vitamin E Deficiency in Norway: Areej Elkamil, Krisztina K. Johansen, Jan Aasly; J Mov Disord. 2015;8(1):33-36. Published online January 31, 2015; DOI: https://doi.org/10.14802/jmd.14030

13,753 View
183 Download
20 Web of Science
18 Crossref

Abstract PDF

Objective Ataxia with vitamin E deficiency (AVED) is a rare autosomal recessive neurological disorder which usually starts in childhood. The clinical presentation is very similar to Friedreich ataxia, most patients have progressive truncal and extremity ataxia, areflexia, positive Babinski sign, dysarthria and sensory neuropathy.
Methods We made an inquiry to our colleagues in Norway, we included information from a prevalence study published southern Norway and added data from our own known case.
Results A newly published prevalence study of hereditary ataxias (total of 171 subjects) found only one subject with AVED in Southeast Norway. We describe two more patients, one from the Central part and one from the Northern part of Norway. All 3 cases had age of onset in early childhood (age of 4–5 years) and all experienced gait ataxia and dysarthria. The genetic testing confirmed that they had pathogenic mutations in the α-tocopherol transfer protein gene (TTPA). All were carriers of the non-sense c.400C > T mutation, one was homozygous for that mutation and the others were compound heterozygous, either with c.358G > A or c.513_514insTT. The homozygous carrier was by far the most severely affected case.
Conclusions We estimate the occurrence of AVED in Norway to be at least 0.6 per million inhabitants. We emphasize that all patients who develop ataxia in childhood should be routinely tested for AVED to make an early diagnosis for initiating treatment with high dose vitamin E to avoid severe neurological deficits.

Citations

Citations to this article as recorded by

A subtle presentation of a treatable cause of predominant hemidystonia with minimal ataxia
S.M. Wrigley, S.S. O'Sullivan, A.M. Ryan
Parkinsonism & Related Disorders.2023; 107: 104909. CrossRef
Genetic heterogeneity within a consanguineous family involving TTPA and SETX genes
Cyrine Jeridi, Amine Rachdi, Fatma Nabli, Zacharia Saied, Rania Zouari, Dina Ben Mohamed, Mariem Ben Said, Saber Masmoudi, Samia Ben Sassi, Rim Amouri
Journal of Neurogenetics.2023; 37(4): 124. CrossRef
Vitamin E – a scoping review for Nordic Nutrition Recommendations 2023
Essi Hantikainen, Ylva Trolle Lagerros
Food & Nutrition Research.2023;[Epub] CrossRef
Autosomal recessive adult onset ataxia
Nataša Dragašević-Mišković, Iva Stanković, Andona Milovanović, Vladimir S. Kostić
Journal of Neurology.2022; 269(1): 504. CrossRef
Vitamin E in foodstuff: Nutritional, analytical, and food technology aspects
Farah Zaaboul, YuanFa Liu
Comprehensive Reviews in Food Science and Food Safety.2022; 21(2): 964. CrossRef
Discovery of Therapeutics Targeting Oxidative Stress in Autosomal Recessive Cerebellar Ataxia: A Systematic Review
Sze Yuen Lew, Michael Weng Lok Phang, Pit Shan Chong, Jaydeep Roy, Chi Him Poon, Wing Shan Yu, Lee Wei Lim, Kah Hui Wong
Pharmaceuticals.2022; 15(6): 764. CrossRef
Clinical and genetic study of ataxia with vitamin E deficiency: A case report
Lin-Wei Zhang, Bing Liu, Dan-Tao Peng
World Journal of Clinical Cases.2022; 10(23): 8271. CrossRef
Fat-soluble vitamins: updated review of their role and orchestration in human nutrition throughout life cycle with sex differences
Rana A. Youness, Alyaa Dawoud, Omar ElTahtawy, Mohamed A. Farag
Nutrition & Metabolism.2022;[Epub] CrossRef
Treatable Ataxias: How to Find the Needle in the Haystack?
Albert Stezin, Pramod Kumar Pal
Journal of Movement Disorders.2022; 15(3): 206. CrossRef
Ataxia with vitamin E deficiency in the Philippines : A case report of two siblings
Ma. Daisy Tabuena, Ryoma Morigaki, Ryosuke Miyamoto, Hideo Mure, Nobuaki Yamamoto, Kazuhisa Miyake, Taku Matsuda, Yuishin Izumi, Yasushi Takagi, Rollin P. Tabuena, Toshitaka Kawarai
The Journal of Medical Investigation.2021; 68(3.4): 400. CrossRef
Essential tremor: the most common form of cerebellar degeneration?
Elan D. Louis, Phyllis L. Faust
Cerebellum & Ataxias.2020;[Epub] CrossRef
Nutrition Can Help DNA Repair in the Case of Aging
Julia Kaźmierczak-Barańska, Karolina Boguszewska, Boleslaw T. Karwowski
Nutrients.2020; 12(11): 3364. CrossRef
Two infants with abetalipoproteinemia: Classic versus atypical presentation
Noparat Prachasitthisak, Pornthep Tanpowpong, Thipwimol Tim‐Aroon, Suporn Treepongkaruna, Nalinee Chongviriyaphan, Niyada Vithayasai, Orawan Iamopas, Duangrurdee Wattanasirichaigoon
Pediatrics International.2019; 61(5): 508. CrossRef
A clinical diagnostic algorithm for early onset cerebellar ataxia
R. Brandsma, C.C. Verschuuren-Bemelmans, D. Amrom, N. Barisic, P. Baxter, E. Bertini, L. Blumkin, V. Brankovic-Sreckovic, O.F. Brouwer, K. Bürk, C.E. Catsman-Berrevoets, D. Craiu, I.F.M. de Coo, J. Gburek, C. Kennedy, T.J. de Koning, H.P.H. Kremer, R. Kum
European Journal of Paediatric Neurology.2019; 23(5): 692. CrossRef
Subacute combined degeneration associated with vitamin E deficiency due to small bowel obstruction
Jong Burm Jung, Yuntae Kim, Kiyoung Oh, Soo A Kim, Joung Hyun Doh, Hye Jeong Oh, Jin Myoung Seok
Medicine.2019; 98(36): e17052. CrossRef
A Review on the Relationship between Tocotrienol and Alzheimer Disease
Kok-Yong Chin, Shu Shen Tay
Nutrients.2018; 10(7): 881. CrossRef
Neurodegeneration bei Vitamin-E-Mangel
S. Neudecker
DGNeurologie.2018; 1(2): 115. CrossRef
Ataxia in children: think about vitamin E deficiency ! (comment on: ataxia in children: early recognition and clinical evaluation)
H. Rahmoune, N. Boutrid, M. Amrane, M. C. Chekkour, B. Bioud
Italian Journal of Pediatrics.2017;[Epub] CrossRef

Botulinum Toxin Clinic-Based Epidemiologic Survey of Adults with Primary Dystonia in East China: Li Wang, Xingyue Hu, Chunfeng Liu, Yiwen Wu, Changqing Wang, Zhiqiang Wang, Jun Chen; J Mov Disord. 2012;5(1):9-13.; DOI: https://doi.org/10.14802/jmd.12003

13,927 View
67 Download
3 Crossref

Abstract PDF

Background and Purpose:

Primary focal or segmental dystonia is a rare clinical condition. The clinical features of dystonia have not been evaluated in China. We performed a study to investigate the epidemiology of primary dystonia and its clinical variants in an adult population.

Methods:

A Botulinum Toxin Clinic-based study was conducted in the period 18 May through 8 October 2010 in East China. We identified 523 dystonia patients from the Movement disorders and Botulinum Toxin clinic Cases.

Results:

The most common focal dystonia were blepharospasm (59%), cervical dystonia (35%), limb dystonia (3%), oromandibular dystonia (2%) and laryngeal dystonia (1%). Males with primary dystonia were noted to have earlier age of onset. A female predominance was noted for most of the primary dystonias with a male to female ratio (M : F) ranging from 1 : 1.48 to 1 : 3.

Conclusions:

The epidemiological features of dystonia in East China we collected were similar to the report in Japan which contrasts partly with that reported in Europe.

Citations

Citations to this article as recorded by

Dystonia: A Leading Neurological Movement Disorder
Md. Tanvir Kabir, Hasina Yasmin, Umme Salma Khanam, Mohd. Raeed Jamiruddin, Md. Sahab Uddin, Mohamed M. Abdel-Daim
Journal of Intellectual Disability - Diagnosis and Treatment.2018; 6(3): 63. CrossRef
Late-onset primary dystonia in Zhejiang province of China: a service-based epidemiological study
Li Wang, Yin Chen, Beibei Hu, Xingyue Hu
Neurological Sciences.2016; 37(1): 111. CrossRef
Tätigkeitsbezogene primäre fokale Dystonien außerhalb der Musikermedizin und ihre Bedeutung für die Arbeitswelt
F. Sladeczek
Zentralblatt für Arbeitsmedizin, Arbeitsschutz und Ergonomie.2015; 65(1): 31. CrossRef

First
Prev
Page of 1
Next
Last

Search