Skip Navigation
Skip to contents

JMD : Journal of Movement Disorders

OPEN ACCESS
SEARCH
Search

Search

Page Path
HOME > Search
3 "Epidemiology"
Filter
Filter
Article category
Keywords
Publication year
Authors
Review Article
Parkinson’s Disease in Sub-Saharan Africa: A Review of Epidemiology, Genetics and Access to Care
Uduak Williams, Oliver Bandmann, Richard Walker
J Mov Disord. 2018;11(2):53-64.   Published online May 30, 2018
DOI: https://doi.org/10.14802/jmd.17028
  • 13,229 View
  • 214 Download
  • 30 Web of Science
  • 31 Crossref
AbstractAbstract PDF
A low prevalence of Parkinson’s disease (PD) has been reported in the Sub-Saharan Africa (SSA) region. The genetic causes and clinical features of PD in this region have been poorly described. Very few reports have examined the availability and access to evidence-based quality care for people living with PD in this region. We reviewed all publications focusing on idiopathic PD from SSA published up to May 2016 and observed a prevalence of PD ranging from 7/100,000 in Ethiopia to 67/100,000 in Nigeria. The most recent community-based study reported a mean age at onset of 69.4 years. The infrequent occurrence of mutations in established PD genes was also observed in the region. Treatments were non-existent or at best irregular. Additionally, there is a lack of well-trained medical personnel and multidisciplinary teams in most countries in this region. Drugs for treating PD are either not available or unaffordable. Large-scale genetic and epidemiological studies are therefore needed in SSA to provide further insights into the roles of genetics and other etiological factors in the pathogenesis of PD. The quality of care also requires urgent improvement to meet the basic level of care required by PD patients.

Citations

Citations to this article as recorded by  
  • Phytoconstituents of Datura metel extract improved motor coordination in haloperidol-induced cataleptic mice: Dual-target molecular docking and behavioural studies
    Bilqis Abiola Lawal, Yusuf Oloruntoyin Ayipo, Abisola Oyindamola Adekunle, Mohammed Otuofu Amali, Umar Muhammad Badeggi, Waleed A. Alananzeh, Mohd Nizam Mordi
    Journal of Ethnopharmacology.2023; 300: 115753.     CrossRef
  • Particularités de la Maladie de Parkinson de la personne âgée : expérience du service de gériatrie de Fann à Dakar (Sénégal)
    A. Sall, M. Ba, R. Djajheté, D. Ba, S. Zaki, M. Coumé
    NPG Neurologie - Psychiatrie - Gériatrie.2023; 23(134): 85.     CrossRef
  • The Gaps and Prospects of Movement Disorders Education and Research in Africa: A Continental Survey
    Eman Hamid, Kigocha Okengo, Biniyam A. Ayele, Daniel Gams Massi, Samia Ben Sassi, Houyam Tibar, Sarah Misbah El‐Sadig, Soulaimane Mahoui, Julien Razafimahefa, Ange Eric Kouame‐Assouan, Djibrilla Ben‐Adji, Lengane Y.T. Modeste, Muhyadin Hassan Mohamed, Nes
    Movement Disorders.2023; 38(2): 178.     CrossRef
  • Transforming Parkinson's Care in Africa (TraPCAf): protocol for a multimethodology National Institute for Health and Care Research Global Health Research Group project
    R. Walker, N. Fothergill-Misbah, S. Kariuki, O. Ojo, R. Cilia, M. C. J. Dekker, O. Agabi, A. Akpalu, F. Amod, M. Breckons, M. Cham, S. Del Din, C. Dotchin, S. Guggsa, J. Kwasa, D. Mushi, F. O. Nwaokorie, T. Park, L. Rochester, J. Rogathi, F. S. Sarfo, A.
    BMC Neurology.2023;[Epub]     CrossRef
  • Exploring the levodopa-paradox of freezing of gait in dopaminergic medication-naïve Parkinson’s disease populations
    Jamie A. F. Jansen, Tamine T. C. Capato, Sirwan K. L. Darweesh, Egberto R. Barbosa, Rogier Donders, Bastiaan R. Bloem, Jorik Nonnekes
    npj Parkinson's Disease.2023;[Epub]     CrossRef
  • Delivery of Allied Health Therapies to People with Parkinson’s Disease in Africa
    Roberto Cilia, Marieke C.J. Dekker, Esther Cubo, Mary W. Agoriwo
    Journal of Parkinson's Disease.2023; : 1.     CrossRef
  • The intestinal luminal sources of α-synuclein: a gastroenterologist perspective
    Aaron Lerner
    Nutrition Reviews.2022; 80(2): 282.     CrossRef
  • Surveying Global Availability of Parkinson’s Disease Treatment
    Zhao H.K. Goh, Julia L.Y. Cheong, Connie Marras, Caroline M. Tanner, Meike Kasten, Amos D. Korczyn, Lana Chahine, Raymond Lo, Alastair J. Noyce
    Journal of Parkinson's Disease.2022; 12(3): 1023.     CrossRef
  • Current Status of Next-Generation Sequencing Approaches for Candidate Gene Discovery in Familial Parkinson´s Disease
    Nikita Simone Pillay, Owen A. Ross, Alan Christoffels, Soraya Bardien
    Frontiers in Genetics.2022;[Epub]     CrossRef
  • Utility of 18F FDG-PET in Parkinsonism in an African population
    Ferzana Hassan Amod, Ahmed Iqbal Bhigjee, Nozipho Nyakale
    eNeurologicalSci.2022; 27: 100399.     CrossRef
  • A Narrative Review of Specialist Parkinson’s Nurses: Evolution, Evidence and Expectation
    Emma Tenison, Alice James, Louise Ebenezer, Emily J. Henderson
    Geriatrics.2022; 7(2): 46.     CrossRef
  • Treatment with bark extracts of Voacanga africana attenuates motor coordination deficit, depressive-like behavior and microglial reaction, in a mouse model of early Parkinson's disease
    Salimata Diagne Houndjo, Christophe Melon, Pascal Salin, Abdoulaye Samb, Fatou Bintou Sarr, Lydia Kerkerian-Le Goff, Sylviane Lortet
    Phytomedicine Plus.2022; 2(3): 100297.     CrossRef
  • Polygenic risk prediction and SNCA haplotype analysis in a Latino Parkinson's disease cohort
    Douglas P. Loesch, Andrea R.V.R. Horimoto, Elif Irem Sarihan, Miguel Inca-Martinez, Emily Mason, Mario Cornejo-Olivas, Luis Torres, Pilar Mazzetti, Carlos Cosentino, Elison Sarapura-Castro, Andrea Rivera-Valdivia, Angel C. Medina, Elena Dieguez, Victor Ra
    Parkinsonism & Related Disorders.2022; 102: 7.     CrossRef
  • The impact of COVID‐19 on patients with neurological disorders and their access to healthcare in Africa: A review of the literature
    Olivier Uwishema, Kristian Steen Frederiksen, Inês F. Silva Correia, Ashraf Mahmoud, Helen Onyeaka, Burhan Dost
    Brain and Behavior.2022;[Epub]     CrossRef
  • Perspective: Low Risk of Parkinson's Disease in Quasi-Vegan Cultures May Reflect GCN2-Mediated Upregulation of Parkin
    Mark F McCarty, Aaron Lerner
    Advances in Nutrition.2021; 12(2): 355.     CrossRef
  • A Rapid Motor Task-Based Screening Tool for Parkinsonism in Community-Based Studies
    Wendy W. Dlamini, Searles Nielsen, Mwiza Ushe, Gill Nelson, Brad A. Racette
    Frontiers in Neurology.2021;[Epub]     CrossRef
  • Parkinson disease-associated cognitive impairment
    Dag Aarsland, Lucia Batzu, Glenda M. Halliday, Gert J. Geurtsen, Clive Ballard, K. Ray Chaudhuri, Daniel Weintraub
    Nature Reviews Disease Primers.2021;[Epub]     CrossRef
  • Probing the Pre-diagnostic Phase of Parkinson's Disease in Population-Based Studies
    Lisanne J. Dommershuijsen, Agnita J. W. Boon, M. Kamran Ikram
    Frontiers in Neurology.2021;[Epub]     CrossRef
  • Medicinal plants for anti-neurodegenerative diseases in West Africa
    Emmanuel Ayodeji Ayeni, Yuzhou Gong, Hao Yuan, Yikao Hu, Xiaolin Bai, Xun Liao
    Journal of Ethnopharmacology.2021; : 114468.     CrossRef
  • Mapping the Diverse and Inclusive Future of Parkinson’s Disease Genetics and Its Widespread Impact
    Inas Elsayed, Alejandro Martinez-Carrasco, Mario Cornejo-Olivas, Sara Bandres-Ciga
    Genes.2021; 12(11): 1681.     CrossRef
  • Parkinson’s disease – a review of pathogenesis, recent advances in management, and challenges of care in sub-Saharan Africa
    Akintomiwa I. Makanjuola, Funmilola T. Taiwo, Joseph O. Yaria, Rufus O. Akinyemi, Adesola Ogunniyi
    Journal of Global Medicine.2021; : e35.     CrossRef
  • Genetics of Parkinson's disease: An introspection of its journey towards precision medicine
    Sara Bandres-Ciga, Monica Diez-Fairen, Jonggeol Jeff Kim, Andrew B. Singleton
    Neurobiology of Disease.2020; 137: 104782.     CrossRef
  • Targeted next-generation sequencing identifies novel variants in candidate genes for Parkinson’s disease in Black South African and Nigerian patients
    Oluwafemi G. Oluwole, Helena Kuivaniemi, Shameemah Abrahams, William L. Haylett, Alvera A. Vorster, Carel J. van Heerden, Colin P. Kenyon, David L. Tabb, Michael B. Fawale, Taofiki A. Sunmonu, Abiodun Ajose, Matthew O. Olaogun, Anastasia C. Rossouw, Ludo
    BMC Medical Genetics.2020;[Epub]     CrossRef
  • Translation, Validation, Diagnostic Accuracy, and Reliability of Screening Questionnaire for Parkinsonism in Three African Countries
    Ali Shalash, Njideka U. Okubadejo, Jacques Doumbe, Oluwadamilola O. Ojo, Eman Hamid, Callixte Kuate, Sara Calvo, Asmaa Helmi, Osigwe P. Agabi, Mohamed Essam, Laura Aguado, Hanan Elrassas, Tamer Roushdy, Caroline M. Tanner, Esther Cubo
    Journal of Parkinson's Disease.2020; 10(3): 1113.     CrossRef
  • Parkinson's Disease Research on the African Continent: Obstacles and Opportunities
    Marieke C. J. Dekker, Toumany Coulibaly, Soraya Bardien, Owen A. Ross, Jonathan Carr, Morenikeji Komolafe
    Frontiers in Neurology.2020;[Epub]     CrossRef
  • Chitosan-Coated Hydroxypropylmethyl Cellulose Microparticles of Levodopa (and Carbidopa): In Vitro and Rat Model Kinetic Characteristics
    Benedicta Obenewaa Dankyi, Seth Kwabena Amponsah, Grace Lovia Allotey-Babington, Ismaila Adams, Nana Aboadwe Goode, Henry Nettey
    Current Therapeutic Research.2020; 93: 100612.     CrossRef
  • Parkinson's disease in Nigeria: A review of published studies and recommendations for future research
    Oluwafemi G. Oluwole, Helena Kuivaniemi, Jonathan A. Carr, Owen A. Ross, Matthew O.B. Olaogun, Soraya Bardien, Morenikeji A. Komolafe
    Parkinsonism & Related Disorders.2019; 62: 36.     CrossRef
  • Clinical series of Parkinson's disease in KwaZulu-Natal, South Africa: Retrospective chart review
    Ferzana Hassan Amod, Ahmed Iqbal Bhigjee
    Journal of the Neurological Sciences.2019; 401: 62.     CrossRef
  • Frequency of the LRRK2 G2019S mutation in South African patients with Parkinson’s disease
    Nicola du Toit, Riaan van Coller, David G. Anderson, Jonathan Carr, Soraya Bardien
    neurogenetics.2019; 20(4): 215.     CrossRef
  • Leucine rich repeat kinase 2 (LRRK2) GLY2019SER mutation is absent in a second cohort of Nigerian Africans with Parkinson disease
    Njideka U. Okubadejo, Mie Rizig, Oluwadamilola O. Ojo, Hallgeir Jonvik, Olajumoke Oshinaike, Emmeline Brown, Henry Houlden, Hiroyoshi Ariga
    PLOS ONE.2018; 13(12): e0207984.     CrossRef
  • Motor Symptoms of Parkinson’s Disease – A Review Literature
    Hilda Aboagyewaa Agyekum
    Neurophysiology and Rehabilitation.2018; : 38.     CrossRef
Original Articles
Ataxia with Vitamin E Deficiency in Norway
Areej Elkamil, Krisztina K. Johansen, Jan Aasly
J Mov Disord. 2015;8(1):33-36.   Published online January 31, 2015
DOI: https://doi.org/10.14802/jmd.14030
  • 12,575 View
  • 174 Download
  • 19 Web of Science
  • 18 Crossref
AbstractAbstract PDF
Objective Ataxia with vitamin E deficiency (AVED) is a rare autosomal recessive neurological disorder which usually starts in childhood. The clinical presentation is very similar to Friedreich ataxia, most patients have progressive truncal and extremity ataxia, areflexia, positive Babinski sign, dysarthria and sensory neuropathy.
Methods We made an inquiry to our colleagues in Norway, we included information from a prevalence study published southern Norway and added data from our own known case.
Results A newly published prevalence study of hereditary ataxias (total of 171 subjects) found only one subject with AVED in Southeast Norway. We describe two more patients, one from the Central part and one from the Northern part of Norway. All 3 cases had age of onset in early childhood (age of 4–5 years) and all experienced gait ataxia and dysarthria. The genetic testing confirmed that they had pathogenic mutations in the α-tocopherol transfer protein gene (TTPA). All were carriers of the non-sense c.400C > T mutation, one was homozygous for that mutation and the others were compound heterozygous, either with c.358G > A or c.513_514insTT. The homozygous carrier was by far the most severely affected case.
Conclusions We estimate the occurrence of AVED in Norway to be at least 0.6 per million inhabitants. We emphasize that all patients who develop ataxia in childhood should be routinely tested for AVED to make an early diagnosis for initiating treatment with high dose vitamin E to avoid severe neurological deficits.

Citations

Citations to this article as recorded by  
  • A subtle presentation of a treatable cause of predominant hemidystonia with minimal ataxia
    S.M. Wrigley, S.S. O'Sullivan, A.M. Ryan
    Parkinsonism & Related Disorders.2023; 107: 104909.     CrossRef
  • Genetic heterogeneity within a consanguineous family involving TTPA and SETX genes
    Cyrine Jeridi, Amine Rachdi, Fatma Nabli, Zacharia Saied, Rania Zouari, Dina Ben Mohamed, Mariem Ben Said, Saber Masmoudi, Samia Ben Sassi, Rim Amouri
    Journal of Neurogenetics.2023; : 1.     CrossRef
  • Vitamin E – a scoping review for Nordic Nutrition Recommendations 2023
    Essi Hantikainen, Ylva Trolle Lagerros
    Food & Nutrition Research.2023;[Epub]     CrossRef
  • Autosomal recessive adult onset ataxia
    Nataša Dragašević-Mišković, Iva Stanković, Andona Milovanović, Vladimir S. Kostić
    Journal of Neurology.2022; 269(1): 504.     CrossRef
  • Vitamin E in foodstuff: Nutritional, analytical, and food technology aspects
    Farah Zaaboul, YuanFa Liu
    Comprehensive Reviews in Food Science and Food Safety.2022; 21(2): 964.     CrossRef
  • Discovery of Therapeutics Targeting Oxidative Stress in Autosomal Recessive Cerebellar Ataxia: A Systematic Review
    Sze Yuen Lew, Michael Weng Lok Phang, Pit Shan Chong, Jaydeep Roy, Chi Him Poon, Wing Shan Yu, Lee Wei Lim, Kah Hui Wong
    Pharmaceuticals.2022; 15(6): 764.     CrossRef
  • Clinical and genetic study of ataxia with vitamin E deficiency: A case report
    Lin-Wei Zhang, Bing Liu, Dan-Tao Peng
    World Journal of Clinical Cases.2022; 10(23): 8271.     CrossRef
  • Fat-soluble vitamins: updated review of their role and orchestration in human nutrition throughout life cycle with sex differences
    Rana A. Youness, Alyaa Dawoud, Omar ElTahtawy, Mohamed A. Farag
    Nutrition & Metabolism.2022;[Epub]     CrossRef
  • Treatable Ataxias: How to Find the Needle in the Haystack?
    Albert Stezin, Pramod Kumar Pal
    Journal of Movement Disorders.2022; 15(3): 206.     CrossRef
  • Ataxia with vitamin E deficiency in the Philippines : A case report of two siblings
    Ma. Daisy Tabuena, Ryoma Morigaki, Ryosuke Miyamoto, Hideo Mure, Nobuaki Yamamoto, Kazuhisa Miyake, Taku Matsuda, Yuishin Izumi, Yasushi Takagi, Rollin P. Tabuena, Toshitaka Kawarai
    The Journal of Medical Investigation.2021; 68(3.4): 400.     CrossRef
  • Essential tremor: the most common form of cerebellar degeneration?
    Elan D. Louis, Phyllis L. Faust
    Cerebellum & Ataxias.2020;[Epub]     CrossRef
  • Nutrition Can Help DNA Repair in the Case of Aging
    Julia Kaźmierczak-Barańska, Karolina Boguszewska, Boleslaw T. Karwowski
    Nutrients.2020; 12(11): 3364.     CrossRef
  • Two infants with abetalipoproteinemia: Classic versus atypical presentation
    Noparat Prachasitthisak, Pornthep Tanpowpong, Thipwimol Tim‐Aroon, Suporn Treepongkaruna, Nalinee Chongviriyaphan, Niyada Vithayasai, Orawan Iamopas, Duangrurdee Wattanasirichaigoon
    Pediatrics International.2019; 61(5): 508.     CrossRef
  • A clinical diagnostic algorithm for early onset cerebellar ataxia
    R. Brandsma, C.C. Verschuuren-Bemelmans, D. Amrom, N. Barisic, P. Baxter, E. Bertini, L. Blumkin, V. Brankovic-Sreckovic, O.F. Brouwer, K. Bürk, C.E. Catsman-Berrevoets, D. Craiu, I.F.M. de Coo, J. Gburek, C. Kennedy, T.J. de Koning, H.P.H. Kremer, R. Kum
    European Journal of Paediatric Neurology.2019; 23(5): 692.     CrossRef
  • Subacute combined degeneration associated with vitamin E deficiency due to small bowel obstruction
    Jong Burm Jung, Yuntae Kim, Kiyoung Oh, Soo A Kim, Joung Hyun Doh, Hye Jeong Oh, Jin Myoung Seok
    Medicine.2019; 98(36): e17052.     CrossRef
  • A Review on the Relationship between Tocotrienol and Alzheimer Disease
    Kok-Yong Chin, Shu Tay
    Nutrients.2018; 10(7): 881.     CrossRef
  • Neurodegeneration bei Vitamin-E-Mangel
    S. Neudecker
    DGNeurologie.2018; 1(2): 115.     CrossRef
  • Ataxia in children: think about vitamin E deficiency ! (comment on: ataxia in children: early recognition and clinical evaluation)
    H. Rahmoune, N. Boutrid, M. Amrane, M. C. Chekkour, B. Bioud
    Italian Journal of Pediatrics.2017;[Epub]     CrossRef
Botulinum Toxin Clinic-Based Epidemiologic Survey of Adults with Primary Dystonia in East China
Li Wang, Xingyue Hu, Chunfeng Liu, Yiwen Wu, Changqing Wang, Zhiqiang Wang, Jun Chen
J Mov Disord. 2012;5(1):9-13.
DOI: https://doi.org/10.14802/jmd.12003
  • 13,015 View
  • 66 Download
  • 2 Crossref
AbstractAbstract PDF
Background and Purpose:

Primary focal or segmental dystonia is a rare clinical condition. The clinical features of dystonia have not been evaluated in China. We performed a study to investigate the epidemiology of primary dystonia and its clinical variants in an adult population.

Methods:

A Botulinum Toxin Clinic-based study was conducted in the period 18 May through 8 October 2010 in East China. We identified 523 dystonia patients from the Movement disorders and Botulinum Toxin clinic Cases.

Results:

The most common focal dystonia were blepharospasm (59%), cervical dystonia (35%), limb dystonia (3%), oromandibular dystonia (2%) and laryngeal dystonia (1%). Males with primary dystonia were noted to have earlier age of onset. A female predominance was noted for most of the primary dystonias with a male to female ratio (M : F) ranging from 1 : 1.48 to 1 : 3.

Conclusions:

The epidemiological features of dystonia in East China we collected were similar to the report in Japan which contrasts partly with that reported in Europe.

Citations

Citations to this article as recorded by  
  • Late-onset primary dystonia in Zhejiang province of China: a service-based epidemiological study
    Li Wang, Yin Chen, Beibei Hu, Xingyue Hu
    Neurological Sciences.2016; 37(1): 111.     CrossRef
  • Tätigkeitsbezogene primäre fokale Dystonien außerhalb der Musikermedizin und ihre Bedeutung für die Arbeitswelt
    F. Sladeczek
    Zentralblatt für Arbeitsmedizin, Arbeitsschutz und Ergonomie.2015; 65(1): 31.     CrossRef

JMD : Journal of Movement Disorders