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Review Article
- Cell Therapy Strategies vs. Paracrine Effect in Huntington’s Disease
- Wooseok Im, Manho Kim
- J Mov Disord. 2014;7(1):1-6. Published online April 30, 2014
- DOI: https://doi.org/10.14802/jmd.14001
- 14,792 View
- 88 Download
- 6 Web of Science
- 5 Crossref
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Abstract
PDF - Huntington’s disease (HD) is a genetic neurodegenerative disorder. The most common symptom of HD is abnormal involuntary writhing movements, called chorea. Antipsychotics and tetrabenazine are used to alleviate the signs and symptoms of HD. Stem cells have been investigated for use in neurodegenerative disorders to develop cell therapy strategies. Recent evidence indicates that the beneficial effects of stem cell therapies are actually mediated by secretory molecules, as well as cell replacement. Although stem cell studies show that cell transplantation provides cellular improvement around lesions in in vivo models, further work is required to elucidate some issues before the clinical application of stem cells. These issues include the precise mechanism of action, delivery method, toxicity and safety. With a focus on HD, this review summarizes cell therapy strategies and the paracrine effect of stem cells.
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Citations
Citations to this article as recorded by
- Current Understanding of Stem Cell and Secretome Therapies in Liver Diseases
Dongkyu Kim, Gun-Sik Cho, Choongseong Han, Dong-Hyuk Park, Hee-Kyung Park, Dong-Hun Woo, Jong-Hoon Kim
Tissue Engineering and Regenerative Medicine.2017; 14(6): 653. CrossRef - Induced Pluripotent Stem Cells in Huntington’s Disease: Disease Modeling and the Potential for Cell-Based Therapy
Ling Liu, Jin-Sha Huang, Chao Han, Guo-Xin Zhang, Xiao-Yun Xu, Yan Shen, Jie Li, Hai-Yang Jiang, Zhi-Cheng Lin, Nian Xiong, Tao Wang
Molecular Neurobiology.2016; 53(10): 6698. CrossRef - Stem Cells in Neurological Disorders: Emerging Therapy with Stunning Hopes
Ghanshyam Upadhyay, Sharmila Shankar, Rakesh K. Srivastava
Molecular Neurobiology.2015; 52(1): 610. CrossRef - Genome Modification Leads to Phenotype Reversal in Human Myotonic Dystrophy Type 1 Induced Pluripotent Stem Cell-Derived Neural Stem Cells
Guangbin Xia, Yuanzheng Gao, Shouguang Jin, S.H. Subramony, Naohiro Terada, Laura P.W. Ranum, Maurice S. Swanson, Tetsuo Ashizawa
Stem Cells.2015; 33(6): 1829. CrossRef - Glycogen synthase kinase 3β inhibition enhanced proliferation, migration and functional re-endothelialization of endothelial progenitor cells in hypercholesterolemia microenvironment
Bin Cui, Jun Jin, Xiaohan Ding, Mengyang Deng, Shiyong Yu, MingBao Song, Yang Yu, Xiaohui Zhao, Jianfei Chen, Lan Huang
Experimental Biology and Medicine.2015; 240(12): 1752. CrossRef
- Current Understanding of Stem Cell and Secretome Therapies in Liver Diseases
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