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Original Articles
Impact of Upper Eyelid Surgery on Symptom Severity and Frequency in Benign Essential Blepharospasm
Hannah Mary Timlin, Kailun Jiang, Daniel George Ezra
J Mov Disord. 2021;14(1):53-59.   Published online January 12, 2021
DOI: https://doi.org/10.14802/jmd.20075
  • 4,957 View
  • 105 Download
  • 1 Web of Science
  • 2 Crossref
AbstractAbstract PDF
Objective
To assess the impact of periocular surgery, other than orbicularis stripping, on the severity and frequency of blepharospasm symptoms.
Methods
Consecutive patients with benign essential blepharospasm (BEB) who underwent eyelid/eyebrow surgery with the aim of improving symptoms were retrospectively reviewed over a 5-year period. Patients who had completed the Jankovic Rating Scale (JRS) and Blepharospasm Disability Index (BDI) pre- and at least 3 months postoperatively were included.
Results
Twenty-four patients were included. JRS scores significantly improved from 7.0 preoperatively to 4.1 postoperatively (p < 0.001), and BDI scores significantly improved from 18.4 preoperatively to 12.7 postoperatively (p < 0.001); the mean percentage improvements were 41% and 30%, respectively. Patients were followed for a median of 24 months postoperatively.
Conclusion
Periocular surgery significantly reduced BEB symptoms in the majority (83%) of patients by an average of 33% and may therefore be offered for suitable patients. An important minority (17%) of patients experienced symptom worsening.

Citations

Citations to this article as recorded by  
  • The long-term response to botulinum toxin injections in patients with blepharospasm undergoing upper eyelid surgery
    Assunta Trinchillo, Nunzia Cuomo, Francesco Habetswallner, Marcello Esposito
    Parkinsonism & Related Disorders.2024; 119: 105958.     CrossRef
  • Blepharospasm Secondary to Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson Disease: Clinical Characteristics and Management Outcomes
    Michelle A. Ting, Alexandra I. Manta, Emma Samia-Aly, Michelle Lai, Emanuel R. de Carvalho, Philip Buttery, Daniel G. Ezra
    Journal of Neuro-Ophthalmology.2023;[Epub]     CrossRef
Sensory Trick Frames: A New Device for Blepharospasm Patients
Daniele Lorenzano, Steven Tansley, Daniel G. Ezra
J Mov Disord. 2019;12(1):22-26.   Published online January 16, 2019
DOI: https://doi.org/10.14802/jmd.18010
  • 8,706 View
  • 184 Download
  • 6 Web of Science
  • 7 Crossref
AbstractAbstract PDF
Objective
To determine whether the use of unique customized spectacles provided with modified side arms may be helpful in reducing benign essential blepharospasm (BEB) in patients describing periocular sensory tricks (ST).
Methods
A prospective descriptive study of patients with BEB with positive periocular or temporal region ST phenomenon response under the care of the Botox Clinic at Moorfields Eye Hospital, London, UK. Nine consecutive patients with BEB describing ST were recruited, and the disease frequency and severity were assessed with the Jankovic Rating Scale (JRS) and the Blepharospasm Disability Index (BSDI) before and after the use of the sensory trick frames (STF).
Results
A reduction in the score was noted in both severity (p = 0.0115) and frequency patterns (p = 0.0117) in the JRS in patients using the STF. A significant reduction of the BSDI score was also observed (p = 0.0314).
Conclusion
All the patients selected and fitted with the STF had a reduction in spasms and related symptoms. This new device may be helpful in some selected BEB patients who previously responded positively to periocular pressure alleviating maneuvers.

Citations

Citations to this article as recorded by  
  • Electrically Induced Sensory Trick in a Patient with Musician’s Dystonia: A Case Report
    Daisuke Nishida, Katsuhiro Mizuno, Osamu Takahashi, Meigen Liu, Tetsuya Tsuji
    Brain Sciences.2023; 13(2): 223.     CrossRef
  • Evaluation of Blepharoptosis in Patients With Refractory Blepharospasm by VISA—Video Recordings, Idiosyncratic Expressions, Sensory Tricks, and Ancillary Procedures
    Chung-Sheng Lai, Savitha Ramachandran, Chia-Chen Lee, Ya-Wei Lai, Yang-Pei Chang, Shu-Hung Huang
    Annals of Plastic Surgery.2023; 90(5S): S172.     CrossRef
  • Variability of Movement Disorders: The Influence of Sensation, Action, Cognition, and Emotions
    Rok Berlot, John C. Rothwell, Kailash P. Bhatia, Maja Kojović
    Movement Disorders.2021; 36(3): 581.     CrossRef
  • Impact of Upper Eyelid Surgery on Symptom Severity and Frequency in Benign Essential Blepharospasm
    Hannah Mary Timlin, Kailun Jiang, Daniel George Ezra
    Journal of Movement Disorders.2021; 14(1): 53.     CrossRef
  • Benign essential blepharospasm: epidemiology, clinical manifestations, pathophysiology, botulinum toxin therapy
    Z. A. Zalyalova
    Neurology, Neuropsychiatry, Psychosomatics.2021; 13(1): 119.     CrossRef
  • Best Practices in the Clinical Management of Progressive Supranuclear Palsy and Corticobasal Syndrome: A Consensus Statement of the CurePSP Centers of Care
    Brent Bluett, Alexander Y. Pantelyat, Irene Litvan, Farwa Ali, Diana Apetauerova, Danny Bega, Lisa Bloom, James Bower, Adam L. Boxer, Marian L. Dale, Rohit Dhall, Antoine Duquette, Hubert H. Fernandez, Jori E. Fleisher, Murray Grossman, Michael Howell, Di
    Frontiers in Neurology.2021;[Epub]     CrossRef
  • Ocular motor manifestations of movement disorders
    Grace F. Crotty, Bart K. Chwalisz
    Current Opinion in Ophthalmology.2019; 30(6): 443.     CrossRef
Case Report
A Case with Improvement of Blepharospasm by Zolpidem
Munkyung Sunwoo, Junghee Cho, Jun Hong Lee, Gyu Sik Kim, Jong Hun Kim, Sun-Ah Choi
J Mov Disord. 2011;4(1):53-54.
DOI: https://doi.org/10.14802/jmd.11010
  • 21,134 View
  • 62 Download
  • 3 Crossref
AbstractAbstract PDF

Zolpidem is usually used for the treatment of insomnia as a hypnotic drug. It was also suggested to be effective in the treatment of dystonia in some studies. A 74-year-old woman had been suffering from frequent and intense bilateral spasms of the eyelids for 20 years. She has been treated with botulinum toxin injection and taken some medications. But, she experienced a little effect and was not satisfied with those treatments. Her symptom was improved after taking Zolpidem which had been prescribed for insomnia by her primary physician. She did not show any improvement after placebo injection and neostigmine test. This is the first report which shows improvement of isolated blepharospasm by Zolpidem in Korea. Zolpidem can be one of useful alternative pharmacological treatments for blepharospasm. Further randomized, blinded, placebo-controlled studies are needed to validate this finding.

Citations

Citations to this article as recorded by  
  • Zolpidem for the Treatment of Dystonia
    Stephanie Patricia J. Badillo, Roland Dominic G. Jamora
    Frontiers in Neurology.2019;[Epub]     CrossRef
  • Can a Positive Allosteric Modulation of GABAergic Receptors Improve Motor Symptoms in Patients with Parkinson’s Disease? The Potential Role of Zolpidem in the Treatment of Parkinson’s Disease
    Antonio Daniele, Francesco Panza, Antonio Greco, Giancarlo Logroscino, Davide Seripa
    Parkinson's Disease.2016; 2016: 1.     CrossRef
  • Medical treatment of dystonia
    Pichet Termsarasab, Thananan Thammongkolchai, Steven J. Frucht
    Journal of Clinical Movement Disorders.2016;[Epub]     CrossRef

JMD : Journal of Movement Disorders