Skip Navigation
Skip to contents

JMD : Journal of Movement Disorders

OPEN ACCESS
SEARCH
Search

Search

Page Path
HOME > Search
1 "Atypical parkinsonism"
Filter
Filter
Article category
Keywords
Publication year
Authors
Funded articles
Review Article
Clinical Approach to Progressive Supranuclear Palsy
Helen Ling
J Mov Disord. 2016;9(1):3-13.   Published online January 25, 2016
DOI: https://doi.org/10.14802/jmd.15060
  • 34,429 View
  • 1,246 Download
  • 51 Web of Science
  • 47 Crossref
AbstractAbstract PDF
Sixty years ago, Steele, Richardson and Olszewski designated progressive supranuclear palsy (PSP) as a new clinicopathological entity in their seminal paper. Since then, in addition to the classic Richardson’s syndrome (RS), different clinical phenotypic presentations have been linked with this four-repeat tauopathy. The clinical heterogeneity is associated with variability of regional distribution and severity of abnormal tau accumulation and neuronal loss. In PSP subtypes, the presence of certain clinical pointers may be useful for antemortem prediction of the underlying PSP-tau pathology. Midbrain atrophy on conventional MRI correlates with the clinical phenotype of RS but is not predictive of PSP pathology. Cerebrospinal fluid biomarkers and tau ligand positron emission tomography are promising biomarkers of PSP. A multidisciplinary approach to meet the patients’ complex needs is the current core treatment strategy for this devastating disorder.

Citations

Citations to this article as recorded by  
  • PSP-Richardson syndrome mimics: An overview and pragmatic approach
    J. Necpál, M. Borsek, B. Jeleňová
    Revue Neurologique.2024; 180(1-2): 12.     CrossRef
  • Mechanisms linking cerebrovascular dysfunction and tauopathy: Adding a layer of epiregulatory complexity
    Yoon A. Kim, Marian Mellen, Caghan Kizil, Ismael Santa‐Maria
    British Journal of Pharmacology.2024; 181(6): 879.     CrossRef
  • Concomitant Medications for Progressive Supranuclear Palsy
    Jay M. Iyer, Douglas Gunzler, Anthony E. Lang, Lawrence I. Golbe, Alexander Pantelyat, Adam L. Boxer, Anne-Marie Wills
    JAMA Neurology.2024; 81(3): 295.     CrossRef
  • Existing statistical measures and techniques in detecting and evaluating progressive supranuclear palsy, its phenotypes by using MRI modalities: A Review
    Nirmal Adam Sait, J Kathirvelan
    Materials Today: Proceedings.2023; 80: 2000.     CrossRef
  • The role of magnetic resonance imaging in the diff erential diagnosis of Parkinson’s disease
    A. A. Tappakhov, T. E. Popova
    Russian neurological journal.2023; 28(1): 5.     CrossRef
  • Clinical features of progressive supranuclear palsy
    Yafei Wen, Qijie Yang, Bin Jiao, Weiwei Zhang, Jingyi Lin, Yuan Zhu, Qian Xu, Hui Zhou, Ling Weng, Xinxin Liao, Yafang Zhou, Junling Wang, Jifeng Guo, Xinxiang Yan, Hong Jiang, Beisha Tang, Lu Shen
    Frontiers in Aging Neuroscience.2023;[Epub]     CrossRef
  • Midbrain area and the hummingbird sign from brain MRI in progressive supranuclear palsy and idiopathic normal pressure hydrocephalus
    Johan Virhammar, Harald Blohmé, Dag Nyholm, Charalampos Georgiopoulos, David Fällmar
    Journal of Neuroimaging.2022; 32(1): 90.     CrossRef
  • Cognitive, Psychiatric, and Motor Symptoms–Based Algorithmic Approach to Differentiate Among Various Types of Dementia Syndromes
    Rehab Magdy, Mona Hussein
    Journal of Nervous & Mental Disease.2022; 210(2): 129.     CrossRef
  • Idiopathic normal pressure hydrocephalus-like MRI features in patients with progressive supranuclear palsy: a comparative case-control study
    Halil Onder, Bilge Kocer, Selcuk Comoglu
    Neurological Research.2022; 44(9): 807.     CrossRef
  • Targeting alpha-synuclein or tau for treating neurodegenerative movement disorders
    M. Lopez-Cuina, W.G. Meissner
    Revue Neurologique.2022; 178(5): 460.     CrossRef
  • Clinical Aspects of the Differential Diagnosis of Parkinson’s Disease and Parkinsonism
    Hae-Won Shin, Sang-Wook Hong, Young Chul Youn
    Journal of Clinical Neurology.2022; 18(3): 259.     CrossRef
  • Dopamine transporter imaging in progressive supranuclear palsy: Severe but nonspecific to subtypes
    Qi‐Si Chen, Xin‐Yi Li, Ling Li, Jia‐Ying Lu, Yi‐Min Sun, Feng‐Tao Liu, Chuan‐Tao Zuo, Jian Wang
    Acta Neurologica Scandinavica.2022; 146(3): 237.     CrossRef
  • CSF tau microtubule-binding region identifies pathological changes in primary tauopathies
    Kanta Horie, Nicolas R. Barthélemy, Salvatore Spina, Lawren VandeVrede, Yingxin He, Ross W. Paterson, Brenton A. Wright, Gregory S. Day, Albert A. Davis, Celeste M. Karch, William W. Seeley, Richard J. Perrin, Rama K. Koppisetti, Faris Shaikh, Argentina L
    Nature Medicine.2022; 28(12): 2547.     CrossRef
  • Role of Multivoxel MR Spectroscopy Progressive Supranuclear Palsy – A Preliminary Study
    Sandhya Mangalore, Manoj Kumar, Pramod Pal, Jitender Saini, Shaik Pasha, Ravi Yadav
    Neurology India.2022; 70(6): 2388.     CrossRef
  • Genetics of Progressive Supranuclear Palsy: A Review
    Yafei Wen, Yafang Zhou, Bin Jiao, Lu Shen
    Journal of Parkinson's Disease.2021; 11(1): 93.     CrossRef
  • Disease course and treatment patterns in progressive supranuclear palsy: A real-world study
    John C. Morgan, Xiaolan Ye, Jennifer A. Mellor, Keisha J. Golden, Jorge Zamudio, Louis A. Chiodo, Yanjun Bao, Tao Xie
    Journal of the Neurological Sciences.2021; 421: 117293.     CrossRef
  • Central nystagmus in progressive supranuclear palsy: A neglected clinical feature?
    Maja Klarendic, Manja Hribar, Nina Bozanic Urbancic, Nina Zupancic, Milica G. Kramberger, Maja Trost, Saba Battelino, Diego Kaski, Maja Kojovic
    Parkinsonism & Related Disorders.2021; 84: 15.     CrossRef
  • Safety and efficacy of tilavonemab in progressive supranuclear palsy: a phase 2, randomised, placebo-controlled trial
    Günter U Höglinger, Irene Litvan, Nuno Mendonca, Deli Wang, Hui Zheng, Beatrice Rendenbach-Mueller, Hoi-Kei Lon, Ziyi Jin, Nahome Fisseha, Kumar Budur, Michael Gold, Davis Ryman, Hana Florian, Anwar Ahmed, Ikuko Aiba, Alberto Albanese, Kelly Bertram, Yvet
    The Lancet Neurology.2021; 20(3): 182.     CrossRef
  • A Study on the Essential and Parkinson’s Arm Tremor Classification
    Vasileios Skaramagkas, George Andrikopoulos, Zinovia Kefalopoulou, Panagiotis Polychronopoulos
    Signals.2021; 2(2): 201.     CrossRef
  • Progressive Supranuclear Palsy: Improvement in Cognitive-Behavioral Disturbances and Motor-Function Disabilities Following Treatment With Antidepressants and Cholinesterase Inhibitors
    Michelle Oyeka, Terngu Ibilah, Jacob Israel, Jose Gavito-Higuera, Ricardo Salazar
    Cureus.2021;[Epub]     CrossRef
  • Progressive supranuclear palsy
    N.V. Fedorova, E.V. Bril, T.K. Kulua, A.D. Mikhaylova
    Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova.2021; 121(5): 111.     CrossRef
  • Best Practices in the Clinical Management of Progressive Supranuclear Palsy and Corticobasal Syndrome: A Consensus Statement of the CurePSP Centers of Care
    Brent Bluett, Alexander Y. Pantelyat, Irene Litvan, Farwa Ali, Diana Apetauerova, Danny Bega, Lisa Bloom, James Bower, Adam L. Boxer, Marian L. Dale, Rohit Dhall, Antoine Duquette, Hubert H. Fernandez, Jori E. Fleisher, Murray Grossman, Michael Howell, Di
    Frontiers in Neurology.2021;[Epub]     CrossRef
  • The Genetic Landscape of Parkinsonism-Related Dystonias and Atypical Parkinsonism-Related Syndromes
    Monica Diez-Fairen, Pilar Alvarez Jerez, Joos Berghausen, Sara Bandres-Ciga
    International Journal of Molecular Sciences.2021; 22(15): 8100.     CrossRef
  • MAPT R406W increases tau T217 phosphorylation in absence of amyloid pathology
    Chihiro Sato, Nipun Mallipeddi, Nupur Ghoshal, Brenton A. Wright, Gregory S. Day, Albert A. Davis, Albert H. Kim, Gregory J. Zipfel, Randall J. Bateman, Audrey Gabelle, Nicolas R. Barthélemy
    Annals of Clinical and Translational Neurology.2021; 8(9): 1817.     CrossRef
  • “Parkinson’s disease” on the way to progressive supranuclear palsy: a review on PSP-parkinsonism
    Ján Necpál, Miroslav Borsek, Bibiána Jeleňová
    Neurological Sciences.2021; 42(12): 4927.     CrossRef
  • Estimation and discussion of prognosis in neurologic practice. Communication issues with patient with neurological disease
    E. V. Bril, A. V. Khasina, F. A. Abbasov, O. S. Zimnyakova, N. V. Fedorova
    Medical alphabet.2021; (22): 55.     CrossRef
  • The Progressive Supranuclear Palsy: Past and Present Aspects
    Theodore P. Parthimos, Kleopatra H. Schulpis
    Clinical Gerontologist.2020; 43(2): 155.     CrossRef
  • Machine Learning Techniques to Identify Dementia
    Nivedita Manohar Mathkunti, Shanta Rangaswamy
    SN Computer Science.2020;[Epub]     CrossRef
  • My dad and progressive supranuclear palsy (PSP)
    Heather Angus-Leppan
    Practical Neurology.2020; 20(3): 263.     CrossRef
  • Tauopathy and Movement Disorders—Unveiling the Chameleons and Mimics
    Jacky Ganguly, Mandar Jog
    Frontiers in Neurology.2020;[Epub]     CrossRef
  • A Home-Based, Music-Cued Movement Program Is Feasible and May Improve Gait in Progressive Supranuclear Palsy
    Joanne E. Wittwer, Margaret Winbolt, Meg E. Morris
    Frontiers in Neurology.2019;[Epub]     CrossRef
  • Association of autonomic symptoms with disease progression and survival in progressive supranuclear palsy
    Marcos C B Oliveira, Helen Ling, Andrew J Lees, Janice L Holton, Eduardo De Pablo-Fernandez, Thomas T Warner
    Journal of Neurology, Neurosurgery & Psychiatry.2019; 90(5): 555.     CrossRef
  • Revisiting the diagnostic value of Evans’ index: lessons from an unusual case of normal pressure hydrocephalus with Evans’ index less than 0.3
    Jung E. Park, Hyunjin Ju, Kayeong Im, Kyum-Yil Kwon
    Neurological Sciences.2019; 40(12): 2637.     CrossRef
  • Progressive supranuclear palsy as differential diagnosis of Parkinson's disease in the elderly
    Ricardo Fernández-Ferreira, Raúl Anwar García-Santos, Mayela Rodríguez-Violante, Coral López-Martínez, Ivonne Karina Becerra-Laparra, María Eugenia Torres-Pérez
    Revista Española de Geriatría y Gerontología.2019; 54(5): 251.     CrossRef
  • Neuroinflammation as a Common Feature of Neurodegenerative Disorders
    Leonardo Guzman-Martinez, Ricardo B. Maccioni, Víctor Andrade, Leonardo Patricio Navarrete, María Gabriela Pastor, Nicolas Ramos-Escobar
    Frontiers in Pharmacology.2019;[Epub]     CrossRef
  • On the journey to uncover the causes of selective cellular and regional vulnerability in neurodegeneration
    Zane Jaunmuktane, Sebastian Brandner
    Acta Neuropathologica.2019; 138(5): 677.     CrossRef
  • Clinical Milestones Preceding the Diagnosis of Multiple System Atrophy and Progressive Supranuclear Palsy: A Retrospective Cohort Study
    Louise Wiblin, Rory Durcan, Brook Galna, Mark Lee, David Burn
    Journal of Movement Disorders.2019; 12(3): 177.     CrossRef
  • Prediction of the Clinical Severity of Progressive Supranuclear Palsy by Diffusion Tensor Imaging
    Yao-Liang Chen, Xiang-An Zhao, Shu-Hang Ng, Chin-Song Lu, Yu-Chun Lin, Jur-Shan Cheng, Chih-Chien Tsai, Jiun-Jie Wang
    Journal of Clinical Medicine.2019; 9(1): 40.     CrossRef
  • Tauopathy with hippocampal 4‐repeat tau immunoreactive spherical inclusions: a report of three cases
    Gabor G. Kovacs, Linda K. Kwong, Murray Grossman, David J. Irwin, Edward B. Lee, John L. Robinson, Eunran Suh, Vivianna M. Van Deerlin, Virginia M. Lee, John Q. Trojanowski
    Brain Pathology.2018; 28(2): 274.     CrossRef
  • A case of spinal anesthesia in a patient with progressive supranuclear palsy
    Momoka Tonan, Moritoki Egi, Nana Furushima, Satoshi Mizobuchi
    JA Clinical Reports.2018;[Epub]     CrossRef
  • Is it Useful to Classify PSP and CBD as Different Disorders? Yes
    Helen Ling, Antonella Macerollo
    Movement Disorders Clinical Practice.2018; 5(2): 145.     CrossRef
  • Difficulties in the diagnosis of four repeats (4R) tauopathic parkinsonian syndromes
    Piotr Alster, Ewa Krzyżanowska, Dariusz Koziorowski, Stanisław Szlufik, Dorota Różański, Joanna Noskowska, Justyna Mianowicz, Adrian Michno, Leszek Królicki, Andrzej Friedman
    Neurologia i Neurochirurgia Polska.2018; 52(4): 459.     CrossRef
  • Neuro-ophthalmology of movement disorders
    Olga Waln, Joseph Jankovic
    Expert Review of Ophthalmology.2018; 13(5): 283.     CrossRef
  • Role of Neuroimaging on Differentiation of Parkinson’s Disease and Its Related Diseases
    Toshihide Ogawa, Shinya Fujii, Keita Kuya, Shin-ichiro Kitao, Yuki Shinohara, Mana Ishibashi, Yoshio Tanabe
    Yonago Acta Medica.2018; 61(3): 145.     CrossRef
  • Gait disorders in adults and the elderly
    Walter Pirker, Regina Katzenschlager
    Wiener klinische Wochenschrift.2017; 129(3-4): 81.     CrossRef
  • Transcranial Magnetic Stimulation for the Assessment of Neurodegenerative Disease
    Steve Vucic, Matthew C. Kiernan
    Neurotherapeutics.2017; 14(1): 91.     CrossRef
  • Advances in progressive supranuclear palsy: new diagnostic criteria, biomarkers, and therapeutic approaches
    Adam L Boxer, Jin-Tai Yu, Lawrence I Golbe, Irene Litvan, Anthony E Lang, Günter U Höglinger
    The Lancet Neurology.2017; 16(7): 552.     CrossRef

JMD : Journal of Movement Disorders