Cortical mean diffusivity is reliable in measuring brain abnormalities in drug-naïve essential tremor patients Eek-Sung Lee, Peter Lee, Min Seung Kim, Suk Ki Chang, Sang Won Jo, Seun Ah Lee, Suk Yun Kang Clinical Neurology and Neurosurgery.2023; 230: 107796. CrossRef
Neurotechnological Approaches to the Diagnosis and Treatment of Alzheimer’s Disease Shen Ning, Mehdi Jorfi, Shaun R. Patel, Doo Yeon Kim, Rudolph E. Tanzi Frontiers in Neuroscience.2022;[Epub] CrossRef
Transcranial Magnetic Stimulation in the Treatment of Neurological Diseases Fahad A. Somaa, Tom A. de Graaf, Alexander T. Sack Frontiers in Neurology.2022;[Epub] CrossRef
Tapping the Potential of Multimodal Non-invasive Brain Stimulation to Elucidate the Pathophysiology of Movement Disorders Sakshi Shukla, Nivethida Thirugnanasambandam Frontiers in Human Neuroscience.2021;[Epub] CrossRef
Objective The long-term efficacy of deep brain stimulation (DBS) for motor fluctuations in advanced Parkinson’s disease (PD) has been well established; however, motor fluctuations may recur over time despite multiple adjustments of DBS settings and medications.
Methods We conducted a retrospective chart review of three patients for whom levodopa-carbidopa intestinal gel (LCIG) was additionally administered as a rescue therapy for secondary DBS failure due to the recurrence of motor fluctuations.
Results The three patients had advanced PD with a disease duration of 14–19 years, and had undergone DBS for motor fluctuations refractory to standard medical management. LCIG was administered to the patients because of symptom recurrence years after DBS and provided complementary effects in all patients.
Conclusion The cases presented here show that rescue LCIG therapy may be a complementary treatment option for patients with post-DBS advanced PD who have a recurrence of troublesome motor complications.
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