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Erratum
Modeling α-Synuclein Propagation with Preformed Fibril Injections
Hyun Kyung Chung, Hoang-Anh Ho, Dayana Pérez-Acuña, Seung-Jae Lee
J Mov Disord. 2020;13(1):77-79.   Published online October 14, 2019
DOI: https://doi.org/10.14802/jmd.19046.e
Corrects: J Mov Disord 2019;12(3):139
  • 5,865 View
  • 138 Download
  • 8 Web of Science
  • 8 Crossref
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Citations

Citations to this article as recorded by  
  • Experimental models of Parkinson's disease: Challenges and Opportunities
    Roshan Lal, Aditi singh, Shivam watts, Kanwaljit Chopra
    European Journal of Pharmacology.2024; 980: 176819.     CrossRef
  • Unconventional secretion of α-synuclein mediated by palmitoylated DNAJC5 oligomers
    Shenjie Wu, Nancy C Hernandez Villegas, Daniel W Sirkis, Iona Thomas-Wright, Richard Wade-Martins, Randy Schekman
    eLife.2023;[Epub]     CrossRef
  • Endothelial LRP1-ICD Accelerates Cognition-Associated Alpha-Synuclein Pathology and Neurodegeneration through PARP1 Activation in a Mouse Model of Parkinson’s Disease
    Rui Huang, Yuyuan Gao, Qingrui Duan, Qingxi Zhang, Peikun He, Jianing Chen, Guixian Ma, Limin Wang, Yuhu Zhang, Kun Nie, Lijuan Wang
    Molecular Neurobiology.2023; 60(2): 979.     CrossRef
  • Impaired dopamine release in Parkinson’s disease
    Kaitlyn M L Cramb, Dayne Beccano-Kelly, Stephanie J Cragg, Richard Wade-Martins
    Brain.2023; 146(8): 3117.     CrossRef
  • Traumatic brain injury and the development of parkinsonism: Understanding pathophysiology, animal models, and therapeutic targets
    Smrithi Padmakumar, Praveen Kulkarni, Craig F. Ferris, Benjamin S. Bleier, Mansoor M. Amiji
    Biomedicine & Pharmacotherapy.2022; 149: 112812.     CrossRef
  • Neuroprotective Effects of a Novel Demeclocycline Derivative Lacking Antibiotic Activity: From a Hit to a Promising Lead Compound
    Rodrigo Tomas-Grau, Florencia González-Lizárraga, Diego Ploper, César L. Avila, Sergio B. Socías, Pierre Besnault, Aurore Tourville, Rosa M. Mella, Patricia Villacé, Clarisa Salado, Clémence Rose, Blandine Seon-Méniel, Jean-Michel Brunel, Laurent Ferrié,
    Cells.2022; 11(17): 2759.     CrossRef
  • Intracranial administration of alpha-synuclein fibrils in A30P-synuclein transgenic mice causes robust synucleinopathy and microglial induction
    Renee C Gentzel, Dawn Toolan, Sarah Jinn, Joel B Schachter, Lei Ma, Philipp J Kahle, Sean M Smith, Jacob N Marcus
    Neurobiology of Aging.2021; 106: 12.     CrossRef
  • Functions of Intracellular Alpha-Synuclein in Microglia: Implications for Parkinson’s Disease Risk
    Alix Booms, Gerhard A. Coetzee
    Frontiers in Cellular Neuroscience.2021;[Epub]     CrossRef
Review Articles
Article image
Modeling α-Synuclein Propagation with Preformed Fibril Injections
Hyun Kyung Chung, Hoang-Anh Ho, Dayana Pérez-Acuña, Seung-Jae Lee
J Mov Disord. 2019;12(3):139-151.   Published online September 30, 2019
DOI: https://doi.org/10.14802/jmd.19046
Correction in: J Mov Disord 2020;13(1):77
  • 18,528 View
  • 932 Download
  • 62 Web of Science
  • 57 Crossref
AbstractAbstract PDF
The aggregation of α-synuclein (α-syn) has been implicated in the pathogenesis of many neurodegenerative disorders, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). Postmortem analyses of α-syn pathology, especially that of PD, have suggested that aggregates progressively spread from a few discrete locations to wider brain regions. The neuron-to-neuron propagation of α-syn has been suggested to be the underlying mechanism by which aggregates spread throughout the brain. Many cellular and animal models has been created to study cell-to-cell propagation. Recently, it has been shown that a single injection of preformed fibrils (PFFs) made of recombinant α-syn proteins into various tissues and organs of many different animal species results in widespread α-syn pathology in the central nervous system (CNS). These PFF models have been extensively used to study the mechanism by which aggregates spread throughout the brain. Here, we review what we have learned from PFF models, describe the nature of PFFs and the neuropathological features, neurophysiological characteristics, and behavioral outcomes of the models.

Citations

Citations to this article as recorded by  
  • Glial senescence enhances α-synuclein pathology owing to its insufficient clearance caused by autophagy dysfunction
    Bin Hong, Yosuke Ohtake, Takahide Itokazu, Toshihide Yamashita
    Cell Death Discovery.2024;[Epub]     CrossRef
  • A Surface Imprinted Polymer EIS Sensor for Detecting Alpha-Synuclein, a Parkinson’s Disease Biomarker
    Roslyn Simone Massey, Rishabh Ramesh Appadurai, Ravi Prakash
    Micromachines.2024; 15(2): 273.     CrossRef
  • Dysbiosis of the gut microbiota and its effect on α-synuclein and prion protein misfolding: consequences for neurodegeneration
    Nasir Uddin Mahbub, Md Minarul Islam, Seong-Tshool Hong, Hea-Jong Chung
    Frontiers in Cellular and Infection Microbiology.2024;[Epub]     CrossRef
  • Neuropathogenesis-on-chips for neurodegenerative diseases
    Sarnai Amartumur, Huong Nguyen, Thuy Huynh, Testaverde S. Kim, Ran-Sook Woo, Eungseok Oh, Kyeong Kyu Kim, Luke P. Lee, Chaejeong Heo
    Nature Communications.2024;[Epub]     CrossRef
  • Systemic inflammation activates coagulation and immune cell infiltration pathways in brains with propagating α-synuclein fibril aggregates
    Anne-Line Strange Laursen, Mikkel Vestergaard Olesen, Jonas Folke, Tomasz Brudek, Luisa Harriet Knecht, Florence Sotty, Kate Lykke Lambertsen, Karina Fog, Louise Torp Dalgaard, Susana Aznar
    Molecular and Cellular Neuroscience.2024; 129: 103931.     CrossRef
  • Comparison of Aptamer and Antibody Bioreceptors in the OEGFET Biosensor Platform for Detecting α-Synuclein, a Parkinson's Biomarker
    Roslyn S. Massey, Srishti Johri, Dennis Chan, Matthew R. Holahan, Ravi Prakash
    IEEE Sensors Letters.2024; 8(7): 1.     CrossRef
  • Cognitive dysfunction in animal models of human lewy-body dementia
    Caroline Haikal, Graham M. Winston, Michael G. Kaplitt
    Frontiers in Aging Neuroscience.2024;[Epub]     CrossRef
  • Non-invasive Monitoring of α-Synuclein in Saliva for Parkinson’s Disease Using Organic Electrolyte-Gated FET Aptasensor
    Roslyn S. Massey, Erin M. McConnell, Dennis Chan, Matthew R. Holahan, Maria C. DeRosa, Ravi Prakash
    ACS Sensors.2023; 8(8): 3116.     CrossRef
  • CSF-derived extracellular vesicles from patients with Parkinson’s disease induce symptoms and pathology
    Shay Herman, Ruth Djaldetti, Brit Mollenhauer, Daniel Offen
    Brain.2023; 146(1): 209.     CrossRef
  • Overexpression-Induced α-Synuclein Brain Spreading
    Rita Pinto-Costa, Eugenia Harbachova, Pietro La Vitola, Donato A. Di Monte
    Neurotherapeutics.2023; 20(1): 83.     CrossRef
  • The Role of α-Synuclein in the Regulation of Serotonin System: Physiological and Pathological Features
    Lluis Miquel-Rio, Unai Sarriés-Serrano, Rubén Pavia-Collado, J Javier Meana, Analia Bortolozzi
    Biomedicines.2023; 11(2): 541.     CrossRef
  • α‐Synuclein decoy peptide protects mice against α‐synuclein‐induced memory loss
    Qingyun Guo, Ichiro Kawahata, Wenbin Jia, Haoyang Wang, An Cheng, Yasushi Yabuki, Norifumi Shioda, Kohji Fukunaga
    CNS Neuroscience & Therapeutics.2023; 29(6): 1547.     CrossRef
  • Duodenal alpha‐Synuclein Pathology and Enteric Gliosis in Advanced Parkinson's Disease
    Aron Emmi, Michele Sandre, Francesco Paolo Russo, Giulia Tombesi, Federica Garrì, Marta Campagnolo, Miryam Carecchio, Roberta Biundo, Gaya Spolverato, Veronica Macchi, Edoardo Savarino, Fabio Farinati, Piero Parchi, Andrea Porzionato, Luigi Bubacco, Raffa
    Movement Disorders.2023; 38(5): 885.     CrossRef
  • Retina-to-brain spreading of α-synuclein after intravitreal injection of preformed fibrils
    Dayana Pérez-Acuña, Ka Hyun Rhee, Soo Jean Shin, Jeeyun Ahn, Jee-Young Lee, Seung-Jae Lee
    Acta Neuropathologica Communications.2023;[Epub]     CrossRef
  • Apathy in Parkinson’s Disease: Clinical Patterns and Neurobiological Basis
    Matthieu Béreau, Vincent Van Waes, Mathieu Servant, Eloi Magnin, Laurent Tatu, Mathieu Anheim
    Cells.2023; 12(12): 1599.     CrossRef
  • Translating Pathological Brain Activity Primers in Parkinson’s Disease Research
    Daniela Mirzac, Svenja L. Kreis, Heiko J. Luhmann, Gabriel Gonzalez-Escamilla, Sergiu Groppa
    Research.2023;[Epub]     CrossRef
  • Animal models of Parkinson’s disease: bridging the gap between disease hallmarks and research questions
    Axelle Dovonou, Cyril Bolduc, Victoria Soto Linan, Charles Gora, Modesto R. Peralta III, Martin Lévesque
    Translational Neurodegeneration.2023;[Epub]     CrossRef
  • The Poly-Arginine Peptide R18D Interferes with the Internalisation of α-Synuclein Pre-Formed Fibrils in STC-1 Enteroendocrine Cells
    Anastazja M. Gorecki, Holly Spencer, Bruno P. Meloni, Ryan S. Anderton
    Biomedicines.2023; 11(8): 2089.     CrossRef
  • Alpha‐synuclein fibrils amplified from multiple system atrophy and Parkinson's disease patient brain spread after intracerebral injection into mouse brain
    Shuyu Zhang, Karina Dauer, Timo Strohäker, Lars Tatenhorst, Lucas Caldi Gomes, Simon Mayer, Byung Chul Jung, Woojin S. Kim, Seung‐Jae Lee, Stefan Becker, Friederike Liesche‐Starnecker, Markus Zweckstetter, Paul Lingor
    Brain Pathology.2023;[Epub]     CrossRef
  • Aging, Parkinson’s Disease, and Models: What Are the Challenges?
    Emily Rocha, Manish Chamoli, Shankar J. Chinta, Julie K. Andersen, Ruby Wallis, Erwan Bezard, Matt Goldberg, Tim Greenamyre, Warren Hirst, We-Li Kuan, Deniz Kirik, Laura Niedernhofer, Irit Rappley, Shalini Padmanabhan, Louis-Eric Trudeau, Maria Spillantin
    Aging Biology.2023; 1(1): 20230010.     CrossRef
  • A Novel NOX Inhibitor Alleviates Parkinson’s Disease Pathology in PFF-Injected Mice
    Kwadwo Ofori, Anurupa Ghosh, Dinesh Kumar Verma, Darice Wheeler, Gabriela Cabrera, Jong-Bok Seo, Yong-Hwan Kim
    International Journal of Molecular Sciences.2023; 24(18): 14278.     CrossRef
  • Cortical Lewy body injections induce long-distance pathogenic alterations in the non-human primate brain
    Margaux Teil, Sandra Dovero, Mathieu Bourdenx, Marie-Laure Arotcarena, Morgane Darricau, Gregory Porras, Marie-Laure Thiolat, Inés Trigo-Damas, Celine Perier, Cristina Estrada, Nuria Garcia-Carrillo, María Trinidad Herrero, Miquel Vila, José A. Obeso, Erw
    npj Parkinson's Disease.2023;[Epub]     CrossRef
  • Immunization Effects of a Novel α-Synuclein-Based Peptide Epitope Vaccine in Parkinson’s Disease-Associated Pathology
    Jun Sung Park, Riaz Ahmad, Kyonghwan Choe, Min Hwa Kang, Tae Ju Park, Myeong Ok Kim
    Vaccines.2023; 11(12): 1820.     CrossRef
  • Ellagic Acid Prevents α-Synuclein Spread and Mitigates Toxicity by Enhancing Autophagic Flux in an Animal Model of Parkinson’s Disease
    Nada Radwan, Engila Khan, Mustafa T. Ardah, Tohru Kitada, M. Emdadul Haque
    Nutrients.2023; 16(1): 85.     CrossRef
  • DA-9805 protects dopaminergic neurons from endoplasmic reticulum stress and inflammation
    Sora Kang, Ying Piao, Young Cheol Kang, Suyeol Lim, Youngmi Kim Pak
    Biomedicine & Pharmacotherapy.2022; 145: 112389.     CrossRef
  • Endogenous Levels of Alpha-Synuclein Modulate Seeding and Aggregation in Cultured Cells
    Eftychia Vasili, Antonio Dominguez-Meijide, Manuel Flores-León, Mohammed Al-Azzani, Angeliki Kanellidi, Ronald Melki, Leonidas Stefanis, Tiago Fleming Outeiro
    Molecular Neurobiology.2022; 59(2): 1273.     CrossRef
  • Phosphorylation of endogenous α-synuclein induced by extracellular seeds initiates at the pre-synaptic region and spreads to the cell body
    Shiori Awa, Genjiro Suzuki, Masami Masuda-Suzukake, Takashi Nonaka, Minoru Saito, Masato Hasegawa
    Scientific Reports.2022;[Epub]     CrossRef
  • Evidence of Inflammation in Parkinson’s Disease and Its Contribution to Synucleinopathy
    Thuy Thi Lai, Yun Joong Kim, Hyeo-il Ma, Young Eun Kim
    Journal of Movement Disorders.2022; 15(1): 1.     CrossRef
  • α-Synuclein in Parkinson's disease and advances in detection
    Rong Chen, Xuan Gu, Xiaoying Wang
    Clinica Chimica Acta.2022; 529: 76.     CrossRef
  • Neurons with Cat’s Eyes: A Synthetic Strain of α-Synuclein Fibrils Seeding Neuronal Intranuclear Inclusions
    Francesca De Giorgi, Muhammed Bilal Abdul-Shukkoor, Marianna Kashyrina, Leslie-Ann Largitte, Francesco De Nuccio, Brice Kauffmann, Alons Lends, Florent Laferrière, Sébastien Bonhommeau, Dario Domenico Lofrumento, Luc Bousset, Erwan Bezard, Thierry Buffete
    Biomolecules.2022; 12(3): 436.     CrossRef
  • A Novel NOX Inhibitor Treatment Attenuates Parkinson’s Disease-Related Pathology in Mouse Models
    Anurupa A. Ghosh, Dinesh Kumar Verma, Gabriela Cabrera, Kwadwo Ofori, Karina Hernandez-Quijada, Jae-Kwan Kim, Joo Hee Chung, Michael Moore, Sung Hwan Moon, Jong Bok Seo, Yong-Hwan Kim
    International Journal of Molecular Sciences.2022; 23(8): 4262.     CrossRef
  • Do Naturally Occurring Antioxidants Protect Against Neurodegeneration of the Dopaminergic System? A Systematic Revision in Animal Models of Parkinson's Disease
    Carmen Costas, Lilian R.F. Faro
    Current Neuropharmacology.2022; 20(2): 432.     CrossRef
  • NXP031 prevents dopaminergic neuronal loss and oxidative damage in the AAV-WT-α-synuclein mouse model of Parkinson’s disease
    Min Kyung Song, Levi Adams, Joo Hee Lee, Yoon-Seong Kim, Hemant K. Paudel
    PLOS ONE.2022; 17(7): e0272085.     CrossRef
  • Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo
    Rachel E. Lackie, Aline S. de Miranda, Mei Peng Lim, Vladislav Novikov, Nimrod Madrer, Nadun C. Karunatilleke, Benjamin S. Rutledge, Stephanie Tullo, Anne Brickenden, Matthew E. R. Maitland, David Greenberg, Daniel Gallino, Wen Luo, Anoosha Attaran, Irina
    Acta Neuropathologica.2022; 144(5): 881.     CrossRef
  • Nanomedicine in the Face of Parkinson’s Disease: From Drug Delivery Systems to Nanozymes
    Francisco J. Padilla-Godínez, Leonardo I. Ruiz-Ortega, Magdalena Guerra-Crespo
    Cells.2022; 11(21): 3445.     CrossRef
  • Animal Models of Metabolic Disorders in the Study of Neurodegenerative Diseases: An Overview
    Andreza Fabro de Bem, Rachel Krolow, Hémelin Resende Farias, Victória Linden de Rezende, Daniel Pens Gelain, José Cláudio Fonseca Moreira, João Miguel das Neves Duarte, Jade de Oliveira
    Frontiers in Neuroscience.2021;[Epub]     CrossRef
  • Role of Liver Growth Factor (LGF) in Parkinson’s Disease: Molecular Insights and Therapeutic Opportunities
    Efthalia Angelopoulou, Yam Nath Paudel, Christina Piperi
    Molecular Neurobiology.2021; 58(7): 3031.     CrossRef
  • Trans-synaptic spreading of alpha-synuclein pathology through sensory afferents leads to sensory nerve degeneration and neuropathic pain
    Nelson Ferreira, Nádia Pereira Gonçalves, Asad Jan, Nanna Møller Jensen, Amelia van der Laan, Simin Mohseni, Christian Bjerggaard Vægter, Poul Henning Jensen
    Acta Neuropathologica Communications.2021;[Epub]     CrossRef
  • Pharmacological Inhibition of Brain EGFR Activation By a BBB-penetrating Inhibitor, AZD3759, Attenuates α-synuclein Pathology in a Mouse Model of α-Synuclein Propagation
    Omid Tavassoly, Esther del Cid Pellitero, Frederique Larroquette, Eddie Cai, Rhalena A. Thomas, Vincent Soubannier, Wen Luo, Thomas M. Durcan, Edward A. Fon
    Neurotherapeutics.2021; 18(2): 979.     CrossRef
  • The Future of Incretin-Based Approaches for Neurodegenerative Diseases in Older Adults: Which to Choose? A Review of their Potential Efficacy and Suitability
    Christine Girges, Nirosen Vijiaratnam, Dilan Athauda, Grace Auld, Sonia Gandhi, Thomas Foltynie
    Drugs & Aging.2021; 38(5): 355.     CrossRef
  • Prodromal neuroinvasion of pathological α-synuclein in brainstem reticular nuclei and white matter lesions in a model of α-synucleinopathy
    Nelson Ferreira, Mette Richner, Amelia van der Laan, Ida Bergholdt Jul Christiansen, Christian B Vægter, Jens R Nyengaard, Glenda M Halliday, Joachim Weis, Benoit I Giasson, Ian R Mackenzie, Poul H Jensen, Asad Jan
    Brain Communications.2021;[Epub]     CrossRef
  • Impact of the apelin/APJ axis in the pathogenesis of Parkinson’s disease with therapeutic potential
    Efthalia Angelopoulou, Yam Nath Paudel, Anastasia Bougea, Christina Piperi
    Journal of Neuroscience Research.2021; 99(9): 2117.     CrossRef
  • Adenovirus-induced Reactive Astrogliosis Exacerbates the Pathology of Parkinson’s Disease
    Heeyoung An, Hyowon Lee, Seulkee Yang, Woojin Won, C. Justin Lee, Min-Ho Nam
    Experimental Neurobiology.2021; 30(3): 222.     CrossRef
  • Brain iron enrichment attenuates α‐synuclein spreading after injection of preformed fibrils
    Karina Dauer née Joppe, Lars Tatenhorst, Lucas Caldi Gomes, Shuyu Zhang, Mojan Parvaz, Eleonora Carboni, Anna‐Elisa Roser, Hazem El DeBakey, Mathias Bähr, Katarina Vogel‐Mikuš, Chi Wang Ip, Stefan Becker, Markus Zweckstetter, Paul Lingor
    Journal of Neurochemistry.2021; 159(3): 554.     CrossRef
  • Increased oscillatory power in a computational model of the olfactory bulb due to synaptic degeneration
    J. Kendall Berry, Daniel Cox
    Physical Review E.2021;[Epub]     CrossRef
  • Combining Automated Organoid Workflows with Artificial Intelligence‐Based Analyses: Opportunities to Build a New Generation of Interdisciplinary High‐Throughput Screens for Parkinson's Disease and Beyond
    Henrik Renner, Hans R. Schöler, Jan M. Bruder
    Movement Disorders.2021; 36(12): 2745.     CrossRef
  • Is Multiple System Atrophy a Prion-like Disorder?
    Kurt A. Jellinger, Gregor K. Wenning, Nadia Stefanova
    International Journal of Molecular Sciences.2021; 22(18): 10093.     CrossRef
  • Cortical alpha-synuclein preformed fibrils do not affect interval timing in mice
    Qiang Zhang, Hisham Abdelmotilib, Travis Larson, Cameron Keomanivong, Mackenzie Conlon, Georgina M. Aldridge, Nandakumar S. Narayanan
    Neuroscience Letters.2021; 765: 136273.     CrossRef
  • Temporal Evolution of Inflammation and Neurodegeneration With Alpha-Synuclein Propagation in Parkinson's Disease Mouse Model
    Thuy Thi Lai, Yun Joong Kim, Phuong Thi Nguyen, Young Ho Koh, Tinh Thi Nguyen, Hyeo-il Ma, Young Eun Kim
    Frontiers in Integrative Neuroscience.2021;[Epub]     CrossRef
  • The Concept of α-Synuclein Strains and How Different Conformations May Explain Distinct Neurodegenerative Disorders
    Katja Malfertheiner, Nadia Stefanova, Antonio Heras-Garvin
    Frontiers in Neurology.2021;[Epub]     CrossRef
  • A historical review of multiple system atrophy with a critical appraisal of cellular and animal models
    David J. Marmion, Wouter Peelaerts, Jeffrey H. Kordower
    Journal of Neural Transmission.2021; 128(10): 1507.     CrossRef
  • Exploring the Etiological Links behind Neurodegenerative Diseases: Inflammatory Cytokines and Bioactive Kynurenines
    Masaru Tanaka, József Toldi, László Vécsei
    International Journal of Molecular Sciences.2020; 21(7): 2431.     CrossRef
  • Modeling Parkinson’s Disease With the Alpha-Synuclein Protein
    Mónica Gómez-Benito, Noelia Granado, Patricia García-Sanz, Anne Michel, Mireille Dumoulin, Rosario Moratalla
    Frontiers in Pharmacology.2020;[Epub]     CrossRef
  • Enhanced Susceptibility of PINK1 Knockout Rats to α-Synuclein Fibrils
    Rose B. Creed, Matthew S. Goldberg
    Neuroscience.2020; 437: 64.     CrossRef
  • Pathogenic Mutations Differentially Regulate Cell-to-Cell Transmission of α-Synuclein
    Yuan Guan, Xiaofang Zhao, Fengwei Liu, Shuxin Yan, Yalong Wang, Cuilian Du, Xiuyu Cui, Rena Li, Claire Xi Zhang
    Frontiers in Cellular Neuroscience.2020;[Epub]     CrossRef
  • Dopamine, Alpha-Synuclein, and Mitochondrial Dysfunctions in Parkinsonian Eyes
    Alessia Indrieri, Rocco Pizzarelli, Brunella Franco, Elvira De Leonibus
    Frontiers in Neuroscience.2020;[Epub]     CrossRef
  • Classic and evolving animal models in Parkinson's disease
    Tanvi Pingale, Girdhari Lal Gupta
    Pharmacology Biochemistry and Behavior.2020; 199: 173060.     CrossRef
Article image
Mechanism of Anti-α-Synuclein Immunotherapy
Jun Sung Lee, Seung-Jae Lee
J Mov Disord. 2016;9(1):14-19.   Published online January 25, 2016
DOI: https://doi.org/10.14802/jmd.15059
  • 26,318 View
  • 344 Download
  • 37 Web of Science
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AbstractAbstract PDF
Immunization therapy targeting α-synuclein has emerged as a promising approach for Parkinson’s disease and perhaps for other synucleinopathies. Several antibodies have shown therapeutic effects in mouse models of synucleinopathies and have alleviated the pathological and behavioral phenotypes of these mice. The mechanisms through which the immunization therapy works were initially puzzling, especially given that α-synuclein is a typical cytosolic protein. Recent studies, however, suggested that extracellular α-synuclein is an important pathogenic entity, and hence, a target for immunotherapy. Here, we review the literature describing immunization therapy for synucleinopathies in mouse models and provide current thoughts on the potential mechanisms underlying the therapeutic effects of α-synuclein immunotherapy.

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  • Aggregation-Induced Emission Luminogens: A New Possibility for Efficient Visualization of RNA in Plants
    Zheng-Chao Yang, Li-Xiang Zhao, Yu-Qi Sang, Xin Huang, Xuan-Chen Lin, Zhi-Ming Yu
    Plants.2024; 13(5): 743.     CrossRef
  • Oxidative Stress and Dopaminergic Metabolism: A Major PD Pathogenic Mechanism and Basis of Potential Antioxidant Therapies
    Aamir Rasool, Robina Manzoor, Kaleem Ullah, Ramsha Afzal, Asad Ul-Haq, Hadia Imran, Imdad Kaleem, Tanveer Akhtar, Anum Farrukh, Sahir Hameed, Shahid Bashir
    CNS & Neurological Disorders - Drug Targets.2024; 23(7): 852.     CrossRef
  • Effectiveness of Flavonoid-Rich Diet in Alleviating Symptoms of Neurodegenerative Diseases
    Aneta Szulc, Karolina Wiśniewska, Magdalena Żabińska, Lidia Gaffke, Maria Szota, Zuzanna Olendzka, Grzegorz Węgrzyn, Karolina Pierzynowska
    Foods.2024; 13(12): 1931.     CrossRef
  • Immunisation with UB-312 in the Thy1SNCA mouse prevents motor performance deficits and oligomeric α-synuclein accumulation in the brain and gut
    Jacqui T. Nimmo, Harry Smith, Chang Yi Wang, Jessica L. Teeling, James A. R. Nicoll, Ajay Verma, Jean-Cosme Dodart, Zhi Liu, Feng Lin, Roxana O. Carare
    Acta Neuropathologica.2022; 143(1): 55.     CrossRef
  • Autophagy-Related Pathways in Vesicular Unconventional Protein Secretion
    Shin Hye Noh, Ye Jin Kim, Min Goo Lee
    Frontiers in Cell and Developmental Biology.2022;[Epub]     CrossRef
  • Targeting Macroautophagy as a Therapeutic Opportunity to Treat Parkinson’s Disease
    Irene Sanchez-Mirasierra, Saurav Ghimire, Sergio Hernandez-Diaz, Sandra-Fausia Soukup
    Frontiers in Cell and Developmental Biology.2022;[Epub]     CrossRef
  • A quantitative systems pharmacology model for simulating OFF-Time in augmentation trials for Parkinson’s disease: application to preladenant
    Rachel Rose, Emma Mitchell, Piet Van Der Graaf, Daisuke Takaichi, Jun Hosogi, Hugo Geerts
    Journal of Pharmacokinetics and Pharmacodynamics.2022; 49(6): 593.     CrossRef
  • Neuroimmune crosstalk and evolving pharmacotherapies in neurodegenerative diseases
    Falguni Baidya, Mariya Bohra, Aishika Datta, Deepaneeta Sarmah, Birva Shah, Priya Jagtap, Swapnil Raut, Ankan Sarkar, Upasna Singh, Kiran Kalia, Anupom Borah, Xin Wang, Kunjan R. Dave, Dileep R. Yavagal, Pallab Bhattacharya
    Immunology.2021; 162(2): 160.     CrossRef
  • Electrogastrography for diagnosis of early-stage Parkinson's disease
    Nobuyuki Araki, Yoshitaka Yamanaka, Anupama Poudel, Yoshikatsu Fujinuma, Akira Katagiri, Satoshi Kuwabara, Masato Asahina
    Parkinsonism & Related Disorders.2021; 86: 61.     CrossRef
  • Natural Alkaloid Compounds as Inhibitors for Alpha-Synuclein Seeded Fibril Formation and Toxicity
    Simona S. Ghanem, Hend S. Fayed, Qi Zhu, Jia-Hong Lu, Nishant N. Vaikath, Janarthanan Ponraj, Said Mansour, Omar M. A. El-Agnaf
    Molecules.2021; 26(12): 3736.     CrossRef
  • Tat-p27 Ameliorates Neuronal Damage Reducing α-Synuclein and Inflammatory Responses in Motor Neurons After Spinal Cord Ischemia
    Woosuk Kim, Hyun Jung Kwon, Hyo Young Jung, Kyu Ri Hahn, Seung Myung Moon, Yeo Sung Yoon, In Koo Hwang, Soo Young Choi, Dae Won Kim
    Neurochemical Research.2021; 46(12): 3123.     CrossRef
  • Immunotherapies for Parkinson’s Disease: Progression of Clinical Development
    Jet Shee Teng, Yin Yin Ooi, Soi Moi Chye, Anna Pick Kiong Ling, Rhun Yian Koh
    CNS & Neurological Disorders - Drug Targets.2021; 20(9): 802.     CrossRef
  • Parkinson Disease: Translating Insights from Molecular Mechanisms to Neuroprotection
    Sheila K. Pirooznia, Liana S. Rosenthal, Valina L. Dawson, Ted M. Dawson, Eric Barker
    Pharmacological Reviews.2021; 73(4): 1204.     CrossRef
  • Anti-inflammatory and Neuroprotective Agents in Clinical Trials for CNS Disease and Injury: Where Do We Go From Here?
    Khalil Mallah, Christine Couch, Davis M. Borucki, Amer Toutonji, Mohammed Alshareef, Stephen Tomlinson
    Frontiers in Immunology.2020;[Epub]     CrossRef
  • Targeting α-synuclein by PD03 AFFITOPE® and Anle138b rescues neurodegenerative pathology in a model of multiple system atrophy: clinical relevance
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    Alzheimer's & Dementia.2019; 15(9): 1133.     CrossRef
  • Translational therapies for multiple system atrophy: Bottlenecks and future directions
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    Redox Biology.2018; 14: 600.     CrossRef
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    Journal of Neuroimmunology.2018; 315: 33.     CrossRef
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    Frontiers in Neuroscience.2018;[Epub]     CrossRef
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    Nature Reviews Drug Discovery.2018; 17(9): 641.     CrossRef
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    Scientific Reports.2017;[Epub]     CrossRef
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    Progress in Neurobiology.2017; 157: 2.     CrossRef
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    Current Opinion in Neurology.2016; 29(4): 459.     CrossRef

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