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- Absence of Alpha-Synuclein Pathology in the Stomach of a Patient With Prodromal Dementia With Lewy Bodies
- Chaewon Shin, Seong-Ik Kim, Sung-Hye Park, Jung Hwan Shin, Chan Young Lee, Han-Joon Kim, Hyuk-Joon Lee, Seong-Ho Kong, Yun-Suhk Suh, Han-Kwang Yang, Beomseok Jeon
- J Mov Disord. 2023;16(2):213-216. Published online April 26, 2023
- DOI: https://doi.org/10.14802/jmd.22219
- 2,714 View
- 78 Download
Brief communication
- Sensitivity of Detecting Alpha-Synuclein Accumulation in the Gastrointestinal Tract and Tissue Volume Examined
- Chaewon Shin, Seong-Ik Kim, Sung-Hye Park, Jung Hwan Shin, Chan Young Lee, Han-Kwang Yang, Hyuk-Joon Lee, Seong-Ho Kong, Yun-Suhk Suh, Han-Joon Kim, Beomseok Jeon
- J Mov Disord. 2022;15(3):264-268. Published online July 26, 2022
- DOI: https://doi.org/10.14802/jmd.22042
- 5,926 View
- 125 Download
- 3 Web of Science
- 3 Crossref
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Abstract
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Supplementary Material - Objective
This study aimed to evaluate whether a larger tissue volume increases the sensitivity of detecting alpha-synuclein (AS) pathology in the gastrointestinal (GI) tract.
Methods
Nine patients with Parkinson’s disease (PD) or idiopathic rapid eye movement sleep disorder (iRBD) who underwent GI operation and had full-depth intestinal blocks were included. All patients were selected from our previous study population. A total of 10 slides (5 serial sections from the proximal and distal blocks) per patient were analyzed.
Results
In previous studies, pathologic evaluation revealed phosphorylated AS (+) in 5/9 patients (55.6%) and in 1/5 controls (20.0%); in this extensive examination, this increased to 8/9 patients (88.9%) but remained the same in controls (20.0%). The severity and distribution of positive findings were similar between patients with iRBD and PD.
Conclusion
Examining a large tissue volume increased the sensitivity of detecting AS accumulation in the GI tract. -
Citations
Citations to this article as recorded by
- Gut-initiated alpha synuclein fibrils drive parkinsonism phenotypes: temporal mapping of REM sleep behavior disorder-like and other non-motor symptoms
Daniel Dautan, Wojciech Paslawski, Sergio G. Montejo, Daniel C. Doyon, Valentina I. Brioschi, Roberta Marongiu, Michael G. Kaplitt, Rong Chen, Valina L. Dawson, Xiaoqun Zhang, Ted M. Dawson, Per Svenningsson
Translational Neurodegeneration.2026;[Epub] CrossRef - Tracking prodromal Parkinson’s disease: a five-year follow-up of the PARCAS cohort
Kristina Kulcsarova, Petronela Christova, Martina Bekeova, Sona Muranska, Sona Mrazova, Zuzana Mrazova, Barbora Zecova, Filip Faglic, Simona Suvakova, Norbert Lesko, Laura Gombosova, Zuzana Gdovinova, Matej Skorvanek
Frontiers in Neurology.2025;[Epub] CrossRef - Symmetric and Profound Monoaminergic Degeneration in Parkinson’s Disease with Premotor REM Sleep Behavior Disorder
Kyung Ah Woo, Han-Joon Kim, Jung Hwan Shin, Kangyoung Cho, Hongyoon Choi, Beomseok Jeon
Journal of Parkinson’s Disease.2024; 14(4): 823. CrossRef
- Gut-initiated alpha synuclein fibrils drive parkinsonism phenotypes: temporal mapping of REM sleep behavior disorder-like and other non-motor symptoms
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