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Original Article
Correlation of Sleep Disturbance and Cognitive Impairment in Patients with Parkinson’s Disease
Eun Ja Kim, Joon Hyun Baek, Dong Jin Shin, Hyeon-Mi Park, Yeong-Bae Lee, Kee-Hyung Park, Dong Hoon Shin, Young Noh, Young Hee Sung
J Mov Disord. 2014;7(1):13-18.   Published online April 30, 2014
DOI: https://doi.org/10.14802/jmd.14003
  • 13,475 View
  • 112 Download
  • 10 Web of Science
  • 11 Crossref
AbstractAbstract PDF
Objective: Cognitive impairment is a common nonmotor symptom of Parkinson’s disease (PD) and is associated with high mortality, caregiver distress, and nursing home placement. The risk factors for cognitive decline in PD patients include advanced age, longer disease duration, rapid eye movement sleep behavior disorder, hallucinations, excessive daytime sleepiness, and nontremor symptoms including bradykinesia, rigidity, postural instability, and gait disturbance. We conducted a cross-sectional study to determine which types of sleep disturbances are related to cognitive function in PD patients.
Methods: A total of 71 PD patients (29 males, mean age 66.46 ± 8.87 years) were recruited. All patients underwent the Mini- Mental State Examination (MMSE) and the Korean Version of the Montreal Cognitive Assessments (MoCA-K) to assess global cognitive function. Sleep disorders were evaluated with the Stanford Sleepiness Scale, Epworth Sleepiness Scale, Insomnia Severity Index (ISI), Pittsburg Sleep Quality Index, and Parkinson’s Disease Sleep Scale in Korea (PDSS).
Results: The ISI was correlated with the MMSE, and total PDSS scores were correlated with the MMSE and the MoCA-K. In each item of the PDSS, nocturnal restlessness, vivid dreams, hallucinations, and nocturnal motor symptoms were positively correlated with the MMSE, and nocturnal restlessness and vivid dreams were significantly related to the MoCA-K. Vivid dreams and nocturnal restlessness are considered the most powerful correlation factors with global cognitive function, because they commonly had significant correlation to cognition assessed with both the MMSE and the MoCA-K.

Conclusions: We found a correlation between global cognitive function and sleep disturbances, including vivid dreams and nocturnal restlessness, in PD patients.

Citations

Citations to this article as recorded by  
  • Assessing the Safety and Therapeutic Efficacy of Cannabidiol Lipid Nanoparticles in Alleviating Metabolic and Memory Impairments and Hippocampal Histopathological Changes in Diabetic Parkinson’s Rats
    Sarawut Lapmanee, Sakkarin Bhubhanil, Prapimpun Wongchitrat, Natthawut Charoenphon, Anjaree Inchan, Thitaphat Ngernsutivorakul, Piroonrat Dechbumroong, Mattaka Khongkow, Katawut Namdee
    Pharmaceutics.2024; 16(4): 514.     CrossRef
  • Evaluation and validation of a patient-reported quality-of-life questionnaire for Parkinson’s disease
    Pantelis Stathis, George Papadopoulos
    Journal of Patient-Reported Outcomes.2022;[Epub]     CrossRef
  • Poor sleep quality is associated with fatigue and depression in early Parkinson's disease: A longitudinal study in the PALS cohort
    Matthew Rui En Koh, Cong Yang Chua, Samuel Yong-Ern Ng, Nicole Shuang-Yu Chia, Seyed Ehsan Saffari, Regina Yu-Ying Chen, Xinyi Choi, Dede Liana Heng, Shermyn Xiumin Neo, Kay Yaw Tay, Wing Lok Au, Eng-King Tan, Louis Chew-Seng Tan, Zheyu Xu
    Frontiers in Neurology.2022;[Epub]     CrossRef
  • Dream Content Predicts Motor and Cognitive Decline in Parkinson's Disease
    Abidemi I. Otaiku
    Movement Disorders Clinical Practice.2021; 8(7): 1041.     CrossRef
  • The impact of clinical scales in Parkinson’s disease: a systematic review
    Nikita Aggarwal, Barjinder Singh Saini, Savita Gupta
    The Egyptian Journal of Neurology, Psychiatry and Neurosurgery.2021;[Epub]     CrossRef
  • Depressive symptoms effect subjective sleep quality in Chinese patients with Parkinson’s disease
    Jun Zhu, Min Zhong, Jun Yan, Zhuang Wu, Yang Pan, Bo Shen, Jingde Dong, Li Zhang
    Clinical Neurology and Neurosurgery.2020; 195: 105950.     CrossRef
  • Effects of agomelatine in rotenone-induced Parkinson’s disease in rats
    Caner Günaydın, Bahattin Avcı, Ayhan Bozkurt, Mehmet Emin Önger, Hakan Balcı, S. Sırrı Bilge
    Neuroscience Letters.2019; 699: 71.     CrossRef
  • Sleep quality is associated with the severity of clinical symptoms in Parkinson’s disease
    Bruno T. Junho, Arthur Kummer, Francisco E. Cardoso, Antonio L. Teixeira, Natalia P. Rocha
    Acta Neurologica Belgica.2018; 118(1): 85.     CrossRef
  • Circadian Rest‐Activity Rhythms Predict Cognitive Function in Early Parkinson's Disease Independently of Sleep
    Jade Q. Wu, Peng Li, Karina Stavitsky Gilbert, Kun Hu, Alice Cronin‐Golomb
    Movement Disorders Clinical Practice.2018; 5(6): 614.     CrossRef
  • Sleep Disturbance May Alter White Matter and Resting State Functional Connectivities in Parkinson’s Disease
    Seok Jong Chung, Yong-Ho Choi, Hunki Kwon, Yeong-Hun Park, Hyuk Jin Yun, Han Soo Yoo, Seock Hyeon Moon, Byoung Seok Ye, Young H. Sohn, Jong-Min Lee, Phil Hyu Lee
    Sleep.2017;[Epub]     CrossRef
  • Schlaf und Schlafstörungen bei alten Menschen
    Jeanina Schlitzer, Helmut Frohnhofen
    DNP - Der Neurologe und Psychiater.2015; 16(4): 53.     CrossRef
Case Reports
Novel Compound Heterozygous Mutations in the Pantothenate Kinase 2 Gene in a Korean Patient with Atypical Pantothenate Kinase Associated Neurodegeneration
Sung-Hyouk Kim, Young-Hee Sung, Kee-Hyung Park, Yeung-Bae Lee, Hyeon-Mi Park, Dong Jin Shin, Gu-Hwan Kim
J Mov Disord. 2009;2(1):45-47.
DOI: https://doi.org/10.14802/jmd.09012
  • 21,528 View
  • 80 Download
  • 2 Crossref
AbstractAbstract PDF

Pantothenate kinase-associated neurodegeneration (PKAN) is an autosomal recessive disorder that is characterized by mutations in the pantothenate kinase 2 gene (PANK2) and typical magnetic resonance imaging findings. We report a case of atypical PKAN presenting with generalized dystonia. Our patient had compound heterozygous mutations in the PANK2 gene, including mutation in exon 3 (p.D268G) and exon 4 (p.R330P). To our knowledge, this patient is the first to have the p.R330P mutation and the second to have the p.D268G mutation.

Citations

Citations to this article as recorded by  
  • Atypical pantothenate kinase-associated neurodegeneration: Clinical description of two brothers and a review of the literature
    S. Mahoui, A. Benhaddadi, W. Ameur El Khedoud, M. Abada Bendib, M. Chaouch
    Revue Neurologique.2017; 173(10): 658.     CrossRef
  • Clinical Heterogeneity of Atypical Pantothenate Kinase-Associated Neurodegeneration in Koreans
    Jae-Hyeok Lee, Jongkyu Park, Ho-Sung Ryu, Hyeyoung Park, Young Eun Kim, Jin Yong Hong, Sang Ook Nam, Young-Hee Sung, Seung-Hwan Lee, Jee-Young Lee, Myung Jun Lee, Tae-Hyoung Kim, Chul Hyoung Lyoo, Sun Ju Chung, Seong Beom Koh, Phil Hyu Lee, Jin Whan Cho,
    Journal of Movement Disorders.2016; 9(1): 20.     CrossRef
A Case of Chorea as the Initial Manifestation of SLE Triggered by Estrogen
Su-Hyun Kim, Dong-Jin Shin, Hyeon-Mi Park, Yeong-Bae Lee, Kee-Hyung Park, Young-Hee Sung
J Mov Disord. 2008;1(2):86-89.
DOI: https://doi.org/10.14802/jmd.08016
  • 9,043 View
  • 47 Download
AbstractAbstract PDF

Neurological complications of systemic lupus erythematosus (SLE) are relatively common, but chorea as the initial manifestation of SLE unmasked by exogenous estrogen is very rare. A-46-year old right handed woman presented with generalized chorea since 2 weeks ago. Her medical records revealed that the chorea had appeared within one month after estrogen medication. The laboratory test revealed positive antinuclear antibody (ANA), positive anti-dsDNA and positive anti-histone antibody. After discontinuation of estrogen, her choreic movement was not diminished. We report a case of newly diagnosed SLE attribute to chorea which triggered by estrogen.


JMD : Journal of Movement Disorders