Parkinson’s disease (PD), the second most common neurodegenerative disorder after Alzheimer’s disease, is characterized by the loss of nigral dopaminergic neurons. PD leads to a series of clinical symptoms, including motor and non-motor disturbances. α-synuclein, the major component of Lewy bodies, is a hallmark lesion in PD. In this review, we concentrate on presenting the latest research on the structure, distribution, and function of α-synuclein, and its interactions with PD. We also summarize the clinic applications of α-synuclein, which suggest its use as a biomarker, and the latest progress in α-synuclein therapy.
Citations
Citations to this article as recorded by
Mitochondrial DNA Leakage and cGas/STING Pathway in Microglia: Crosstalk Between Neuroinflammation and Neurodegeneration Yuqian Liu, Bohan Zhang, Ruonan Duan, Yiming Liu Neuroscience.2024; 548: 1. CrossRef
Positron Emission Tomography with [18F]ROStrace Reveals Progressive Elevations in Oxidative Stress in a Mouse Model of Alpha-Synucleinopathy Evan Gallagher, Catherine Hou, Yi Zhu, Chia-Ju Hsieh, Hsiaoju Lee, Shihong Li, Kuiying Xu, Patrick Henderson, Rea Chroneos, Malkah Sheldon, Shaipreeah Riley, Kelvin C. Luk, Robert H. Mach, Meagan J. McManus International Journal of Molecular Sciences.2024; 25(9): 4943. CrossRef
Aggregation-resistant alpha-synuclein tetramers are reduced in the blood of Parkinson’s patients Laura de Boni, Amber Wallis, Aurelia Hays Watson, Alejandro Ruiz-Riquelme, Louise-Ann Leyland, Thomas Bourinaris, Naomi Hannaway, Ullrich Wüllner, Oliver Peters, Josef Priller, Björn H Falkenburger, Jens Wiltfang, Mathias Bähr, Inga Zerr, Katharina Bürger EMBO Molecular Medicine.2024; 16(7): 1657. CrossRef
Navigating the Gene Co-Expression Network and Drug Repurposing Opportunities for Brain Disorders Associated with Neurocognitive Impairment Mathew Timothy Artuz Manuel, Lemmuel L. Tayo Brain Sciences.2023; 13(11): 1564. CrossRef
Glymphatic Magnetic Resonance Imaging: Part II—Applications in Sleep and Neurodegenerative Diseases Hyochul Lee, Roh-Eul Yoo, Seung Hong Choi Investigative Magnetic Resonance Imaging.2023; 27(4): 208. CrossRef
An Enlarged Perivascular Space: Clinical Relevance and the Role of Imaging in Aging and Neurologic Disorders Younghee Yim, Won-Jin Moon Journal of the Korean Society of Radiology.2022; 83(3): 538. CrossRef
Studying the effect of alpha-synuclein and Parkinson’s disease linked mutants on inter pathway connectivities Sagnik Sen, Ashmita Dey, Ujjwal Maulik Scientific Reports.2021;[Epub] CrossRef
A novel role of NLRP3-generated IL-1β in the acute-chronic transition of peripheral lipopolysaccharide-elicited neuroinflammation: implications for sepsis-associated neurodegeneration Zhan Zhao, Yubao Wang, Ran Zhou, Yi Li, Yun Gao, Dezhen Tu, Belinda Wilson, Sheng Song, Jing Feng, Jau-Shyong Hong, Jerrel L. Yakel Journal of Neuroinflammation.2020;[Epub] CrossRef
Different Perivascular Space Burdens in Idiopathic Rapid Eye Movement Sleep Behavior Disorder and Parkinson’s Disease Xiao-li Si, Lu-yan Gu, Zhe Song, Cheng Zhou, Yi Fang, Chong-yao Jin, Jing-jing Wu, Ting Gao, Tao Guo, Xiao-jun Guan, Xiao-jun Xu, Xin-zhen Yin, Ya-ping Yan, Min-min Zhang, Jia-li Pu Frontiers in Aging Neuroscience.2020;[Epub] CrossRef
Central Nervous System-Derived Exosomal Alpha-Synuclein in Serum May Be a Biomarker in Parkinson’s Disease Xiaoli Si, Jun Tian, Yanxing Chen, Yaping Yan, Jiali Pu, Baorong Zhang Neuroscience.2019; 413: 308. CrossRef
Brain and Peripheral Atypical Inflammatory Mediators Potentiate Neuroinflammation and Neurodegeneration Duraisamy Kempuraj, Ramasamy Thangavel, Govindhasamy P. Selvakumar, Smita Zaheer, Mohammad E. Ahmed, Sudhanshu P. Raikwar, Haris Zahoor, Daniyal Saeed, Prashant A. Natteru, Shankar Iyer, Asgar Zaheer Frontiers in Cellular Neuroscience.2017;[Epub] CrossRef