Skip Navigation
Skip to contents

JMD : Journal of Movement Disorders

OPEN ACCESS
SEARCH
Search

Search

Page Path
HOME > Search
1 "Jae-Young An"
Filter
Filter
Article category
Keywords
Publication year
Authors
Funded articles
Original Article
Cardiovascular Autonomic Dysfunction in Mild and Advanced Parkinson’s Disease
Joong-Seok Kim, Si-Hoon Lee, Yoon-Sang Oh, Jeong-Wook Park, Jae-Young An, Sung-Kyung Park, Si-Ryung Han, Kwang-Soo Lee
J Mov Disord. 2016;9(2):97-103.   Published online March 28, 2016
DOI: https://doi.org/10.14802/jmd.16001
  • 17,311 View
  • 194 Download
  • 25 Citations
AbstractAbstract PDF
Objective
The purpose of the present study was to investigate cardiovascular autonomic dysfunction in patients with Parkinson’s disease (PD) with mild to severe stages of motor symptoms and to compare cardiovascular autonomic dysfunction between drug-naïve and dopaminergic drug-treated groups.
Methods
This study included 188 PD patients and 25 age-matched healthy controls who underwent head-up tilt-testing, 24-h ambulatory blood pressure (BP) monitoring and 24-h Holter monitoring. Autonomic function test results were evaluated among groups categorized by motor symptom severities (mild vs. moderate vs. severe) and treatment (drug-naïve or dopaminergic drug treatment).
Results
Orthostatic hypotension and supine hypertension were more frequent in patients with PD than in healthy controls. The frequencies of orthostatic hypotension, supine hypertension, nocturnal hypertension and non-dipping were not different among groups. Additionally, no significant differences were detected in supine BP, orthostatic BP change, nighttime BP, nocturnal BP dipping, or heart rate variabilities among groups.
Conclusions
Cardiovascular autonomic dysfunction is not confined to moderate to severe PD patients, and starts early in the course of the disease in a high proportion of PD patients. In addition, dopaminergic drug treatments do not affect cardiovascular autonomic function.

Citations

Citations to this article as recorded by  
  • Central Aortic Pressure and Arterial Stiffness in Parkinson’s Disease: A Comparative Study
    Mehmet Balal, Meltem Demirkiran, Saime Paydas, Seyed-Mohammad Fereshtehnejad
    Parkinson's Disease.2022; 2022: 1.     CrossRef
  • Blood Pressure Patterns in Patients with Parkinson’s Disease: A Systematic Review
    Delia Tulbă, Liviu Cozma, Paul Bălănescu, Adrian Buzea, Cristian Băicuș, Bogdan Ovidiu Popescu
    Journal of Personalized Medicine.2021; 11(2): 129.     CrossRef
  • Inverted circadian variation of arterial pressure in a geriatric patient: an indicator of autonomic dysfunction
    Siddhartha Lieten, Aziz Debain, Bert Bravenboer, Tony Mets
    BMC Geriatrics.2021;[Epub]     CrossRef
  • Autonomic dysfunction and heart rate variability with Holter monitoring: a diagnostic look at autonomic regulation
    Beatrice De Maria, Laura Adelaide Dalla Vecchia, Alberto Porta, Maria Teresa La Rovere
    Herzschrittmachertherapie + Elektrophysiologie.2021; 32(3): 315.     CrossRef
  • Heart Rate Variability Analyses in Parkinson’s Disease: A Systematic Review and Meta-Analysis
    Konstantin G. Heimrich, Thomas Lehmann, Peter Schlattmann, Tino Prell
    Brain Sciences.2021; 11(8): 959.     CrossRef
  • Association of orthostatic hypotension with Parkinson’s disease: a meta-analysis
    Feifei Mu, Qian Jiao, Xixun Du, Hong Jiang
    Neurological Sciences.2020; 41(6): 1419.     CrossRef
  • Dizziness in patients with early stages of Parkinson's disease: Prevalence, clinical characteristics and implications
    Kyum‐Yil Kwon, Suyeon Park, Mina Lee, Hyunjin Ju, Kayeong Im, Byung‐Euk Joo, Kyung Bok Lee, Hakjae Roh, Moo‐Young Ahn
    Geriatrics & Gerontology International.2020; 20(5): 443.     CrossRef
  • The Dysfunctional Autonomic Function and “Dysfunctional” Fatigue in Drug Naïve Parkinson’s Disease
    Jong Hyeon Ahn, Minkyeong Kim, Jun Kyu Mun, Yoonsu Cho, Ji Sun Kim, Jinyoung Youn, Joong-Seok Kim, Jin Whan Cho
    Journal of Parkinson's Disease.2020; 10(2): 605.     CrossRef
  • Clinical Perspectives of Parkinson's Disease for Ophthalmologists, Otorhinolaryngologists, Cardiologists, Dentists, Gastroenterologists, Urologists, Physiatrists, and Psychiatrists
    Ji-Hyun Choi, Jong-Min Kim, Hee Kyung Yang, Hyo-Jung Lee, Cheol Min Shin, Seong Jin Jeong, Won-Seok Kim, Ji Won Han, In-Young Yoon, Yoo Sung Song, Yun Jung Bae
    Journal of Korean Medical Science.2020;[Epub]     CrossRef
  • Autonomic Dysfunction in Parkinson’s Disease
    Ronald F. Pfeiffer
    Neurotherapeutics.2020; 17(4): 1464.     CrossRef
  • Dysautonomia Is Linked to Striatal Dopamine Deficits and Regional Cerebral Perfusion in Early Parkinson Disease
    Hae-Won Shin, Seok Jong Chung, Sangwon Lee, Jungho Cha, Young H. Sohn, Mijin Yun, Phil Hyu Lee
    Clinical Nuclear Medicine.2020; 45(8): e342.     CrossRef
  • Characteristics of the 24-h ambulatory blood pressure monitoring in patients with Parkinson's disease – the SFC BP multicentre study in China
    Shi-Wu Chen, Yu-Kai Wang, Rong-Hua Dou, Xin-Yi Xie, Yong-Bo Hu, Nan Ding, Guo-Hua Zhang, Hai-Fang Jing, Wei-Dong Zhao, Yan Xue, Yan Li, Gang Wang
    Journal of Hypertension.2020; 38(11): 2270.     CrossRef
  • Parkinson’s disease with orthostatic hypotension: analyses of clinical characteristics and influencing factors
    Lixia Li, Peng Guo, Duyu Ding, Tenghong Lian, Lijun Zuo, Fenghe Du, Wei Zhang
    Neurological Research.2019; 41(8): 734.     CrossRef
  • Neurogenic Orthostatic Hypotension in Parkinson Disease: A Primer
    Jeremy K. Cutsforth-Gregory, Phillip A. Low
    Neurology and Therapy.2019; 8(2): 307.     CrossRef
  • Increased markers of cardiac vagal activity in leucine-rich repeat kinase 2-associated Parkinson’s disease
    Claudia Carricarte Naranjo, Connie Marras, Naomi P. Visanji, David J. Cornforth, Lazaro Sanchez-Rodriguez, Birgitt Schüle, Samuel M. Goldman, Mario Estévez, Phyllis K. Stein, Anthony E. Lang, Herbert F. Jelinek, Andrés Machado
    Clinical Autonomic Research.2019; 29(6): 603.     CrossRef
  • Considerations before initiating therapy in Parkinsonism: basing on the quality of life
    Shu-Jin He, Zhen-Yang Liu, Yu-Jie Yang, Cong Shen, Yu-Jie Du, Xin-Yue Zhou, Jue Zhao, Yi-Min Sun, Ke Yang, Jian-Jun Wu, Feng-Tao Liu, Jian Wang
    Journal of Neurology.2019; 266(12): 3119.     CrossRef
  • Increased risk of all‐cause mortality associated with domperidone use in Parkinson's patients: a population‐based cohort study in the UK
    Marina Simeonova, Frank Vries, Sander Pouwels, Johanna H. M. Driessen, Hubert G.M. Leufkens, Suzanne M. Cadarette, Andrea M. Burden
    British Journal of Clinical Pharmacology.2018; 84(11): 2551.     CrossRef
  • Validation of the Korean Version of the Scale for Outcomes in Parkinson’s Disease-Autonomic
    Ji-Young Kim, In-Uk Song, Seong-Beom Koh, Tae-Beom Ahn, Sang Jin Kim, Sang-Myung Cheon, Jin Whan Cho, Yun Joong Kim, Hyeo-Il Ma, Mee-Young Park, Jong Sam Baik, Phil Hyu Lee, Sun Ju Chung, Jong-Min Kim, Han-Joon Kim, Young-Hee Sung, Do Young Kwon, Jae-Hyeo
    Journal of Movement Disorders.2017; 10(1): 29.     CrossRef
  • Cardiovascular Autonomic Dysfunction in Patients with Drug-Induced Parkinsonism
    Joong-Seok Kim, Dong-Woo Ryu, Ju-Hee Oh, Yang-Hyun Lee, Sung-Jin Park, Kipyung Jeon, Jong-Yun Lee, Seong Hee Ho, Jungmin So, Jin Hee Im, Kwang-Soo Lee
    Journal of Clinical Neurology.2017; 13(1): 15.     CrossRef
  • Normal ‘heart’ in Parkinson's disease: is this a distinct clinical phenotype?
    J.-S. Kim, H.-E. Park, I.-S. Park, Y.-S. Oh, D.-W. Ryu, I.-U. Song, Y.-A. Jung, I. R. Yoo, H.-S. Choi, P. H. Lee, K.-S. Lee
    European Journal of Neurology.2017; 24(2): 349.     CrossRef
  • The composite autonomic symptom scale 31 is a useful screening tool for patients with Parkinsonism
    Younsoo Kim, Jin Myoung Seok, Jongkyu Park, Kun-Hyun Kim, Ju-Hong Min, Jin Whan Cho, Suyeon Park, Hyun-jin Kim, Byoung Joon Kim, Jinyoung Youn, Pedro Gonzalez-Alegre
    PLOS ONE.2017; 12(7): e0180744.     CrossRef
  • Cardiac sympathetic denervation predicts PD in at-risk individuals
    David S. Goldstein, Courtney Holmes, Grisel J. Lopez, Tianxia Wu, Yehonatan Sharabi
    Parkinsonism & Related Disorders.2017;[Epub]     CrossRef
  • Loss of cutaneous large and small fibers in naive and l-dopa–treated PD patients
    Maria Nolano, Vincenzo Provitera, Fiore Manganelli, Rosa Iodice, Annamaria Stancanelli, Giuseppe Caporaso, Annamaria Saltalamacchia, Francesca Califano, Bernardo Lanzillo, Marina Picillo, Paolo Barone, Lucio Santoro
    Neurology.2017; 89(8): 776.     CrossRef
  • Arterial Stiffness and Cardiovascular Autonomic Dysfunction in Patients with Parkinson's Disease
    Joong-Seok Kim, Si-Hoon Lee, Yoon-Sang Oh, Jeong-Wook Park, Jae-Young An, Hyun-Seok Choi, Kwang-Soo Lee
    Neurodegenerative Diseases.2017; 17(2-3): 89.     CrossRef
  • Prevalence and Prescribed Treatments of Orthostatic Hypotension in Institutionalized Patients with Parkinson’s Disease
    ALAJ Hommel, MJ Faber, NJ Weerkamp, JG van Dijk, BR Bloem, RT Koopmans
    Journal of Parkinson's Disease.2016; 6(4): 805.     CrossRef

JMD : Journal of Movement Disorders