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Original Article
- Correlation of Sleep Disturbance and Cognitive Impairment in Patients with Parkinson’s Disease
- Eun Ja Kim, Joon Hyun Baek, Dong Jin Shin, Hyeon-Mi Park, Yeong-Bae Lee, Kee-Hyung Park, Dong Hoon Shin, Young Noh, Young Hee Sung
- J Mov Disord. 2014;7(1):13-18. Published online April 30, 2014
- DOI: https://doi.org/10.14802/jmd.14003
- 14,227 View
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- 11 Web of Science
- 11 Crossref
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Abstract
PDF - Objective: Cognitive impairment is a common nonmotor symptom of Parkinson’s disease (PD) and is associated with high mortality, caregiver distress, and nursing home placement. The risk factors for cognitive decline in PD patients include advanced age, longer disease duration, rapid eye movement sleep behavior disorder, hallucinations, excessive daytime sleepiness, and nontremor symptoms including bradykinesia, rigidity, postural instability, and gait disturbance. We conducted a cross-sectional study to determine which types of sleep disturbances are related to cognitive function in PD patients.
Methods: A total of 71 PD patients (29 males, mean age 66.46 ± 8.87 years) were recruited. All patients underwent the Mini- Mental State Examination (MMSE) and the Korean Version of the Montreal Cognitive Assessments (MoCA-K) to assess global cognitive function. Sleep disorders were evaluated with the Stanford Sleepiness Scale, Epworth Sleepiness Scale, Insomnia Severity Index (ISI), Pittsburg Sleep Quality Index, and Parkinson’s Disease Sleep Scale in Korea (PDSS).
Results: The ISI was correlated with the MMSE, and total PDSS scores were correlated with the MMSE and the MoCA-K. In each item of the PDSS, nocturnal restlessness, vivid dreams, hallucinations, and nocturnal motor symptoms were positively correlated with the MMSE, and nocturnal restlessness and vivid dreams were significantly related to the MoCA-K. Vivid dreams and nocturnal restlessness are considered the most powerful correlation factors with global cognitive function, because they commonly had significant correlation to cognition assessed with both the MMSE and the MoCA-K.
Conclusions: We found a correlation between global cognitive function and sleep disturbances, including vivid dreams and nocturnal restlessness, in PD patients. -
Citations
Citations to this article as recorded by
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Pharmaceutics.2024; 16(4): 514. CrossRef - Evaluation and validation of a patient-reported quality-of-life questionnaire for Parkinson’s disease
Pantelis Stathis, George Papadopoulos
Journal of Patient-Reported Outcomes.2022;[Epub] CrossRef - Poor sleep quality is associated with fatigue and depression in early Parkinson's disease: A longitudinal study in the PALS cohort
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Frontiers in Neurology.2022;[Epub] CrossRef - Dream Content Predicts Motor and Cognitive Decline in Parkinson's Disease
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Clinical Neurology and Neurosurgery.2020; 195: 105950. CrossRef - Effects of agomelatine in rotenone-induced Parkinson’s disease in rats
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Neuroscience Letters.2019; 699: 71. CrossRef - Sleep quality is associated with the severity of clinical symptoms in Parkinson’s disease
Bruno T. Junho, Arthur Kummer, Francisco E. Cardoso, Antonio L. Teixeira, Natalia P. Rocha
Acta Neurologica Belgica.2018; 118(1): 85. CrossRef - Circadian Rest‐Activity Rhythms Predict Cognitive Function in Early Parkinson's Disease Independently of Sleep
Jade Q. Wu, Peng Li, Karina Stavitsky Gilbert, Kun Hu, Alice Cronin‐Golomb
Movement Disorders Clinical Practice.2018; 5(6): 614. CrossRef - Sleep Disturbance May Alter White Matter and Resting State Functional Connectivities in Parkinson’s Disease
Seok Jong Chung, Yong-Ho Choi, Hunki Kwon, Yeong-Hun Park, Hyuk Jin Yun, Han Soo Yoo, Seock Hyeon Moon, Byoung Seok Ye, Young H. Sohn, Jong-Min Lee, Phil Hyu Lee
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