Journal of Movement Disorders

Brief communication

Pre-DBS modified Tremor/Postural instability and gait difficulty score ratio as indicator of short-term outcome of subthalamic nucleus DBS in Parkinson’s disease: Chakradhar Reddy, Kanchana Pillai, Shejoy Joshua, Anup Nair, Harshad Chavotiya, Manas Chacko, Asha Kishore; Received August 5, 2024 Accepted January 2, 2025 Published online January 2, 2025; DOI: https://doi.org/10.14802/jmd.24175 [Accepted]

192 View
11 Download

Abstract PDF: Purpose
-The outcomes of motor and non-motor features of Parkinson’s disease (PD) following DBS vary among its subtypes. We tested whether pre-operative motor subtyping using the modified Tremor/PIGD ratio, could indicate the short-term motor, non-motor and quality of life (QOL) outcomes of STN-DBS.
Method
In this prospective study, 39 consecutive STN-DBS cases were assessed in Drug-OFF state before surgery and subtyped using the ratio of tremor and PIGD scores (T/P ratio). 6 months after surgery patients were reassessed in Stimulation ON-Drug OFF state and the percentage change in motor, non-motor and QOL scores (PDQ39) was calculated.
Results
The modified T/P ratio had a moderate, positive correlation with the percentage change in scores of UPDRS III in OFF, sum of cardinal motor signs, non-motor symptoms scale (NMSS) and quality of life (PDQ39).
Conclusion
Preoperative PD motor subtyping can be used as an indicator of the short-term, outcomes of STN-DBS in PD.

Original Articles

Video-oculography for enhancing the diagnostic accuracy of early oculomotor dysfunction in Progressive Supranuclear Palsy: Harshad Chovatiya, Kanchana Pillai, Chakradhar Reddy, Amiya Thalakkattu, Ayana Avarachan, Manas Chacko, Asha Kishore; Received August 1, 2024 Accepted December 8, 2024 Published online December 9, 2024; DOI: https://doi.org/10.14802/jmd.24171 [Accepted]

385 View
22 Download

Abstract PDF: Background
Oculomotor impairment is an important diagnostic feature of Progressive Supranuclear Palsy (PSP) and PSP subtypes.
Objectives
We assessed the role of video oculography (VOG) in confirming clinically suspected slow saccades in PSP and differentiating PSP from Parkinson’s disease (PD). We also measured the correlation of both saccadic velocity and latency in PSP with scores in PSP rating scale, Montreal Cognitive Assessment (MoCA) and Frontal assessment battery (FAB). We assessed the frequency of apraxia of eyelid opening (ALO) and reflex blepharospasm in PSP and PD.
Method
112 PSP cases with slow saccades but not gaze palsy, 50 PD and 50 healthy controls (HC) were recruited. MDS task force-PSP and PD criteria were used respectively, for the diagnoses. All subjects underwent VOG.
Result
Horizontal and vertical saccadic velocities and latencies differentiated PSP from PD and HC (p<0.001). Vertical saccadic velocity and latency accurately differentiated PSP-P from PD (p<0.001 and 0.003 respectively). Vertical and horizontal saccadic velocities differentiated PSP- RS and PSP- P (p=0.026 and 0.036 respectively). In vertical gaze, the mean velocity cut-off showed good sensitivity and specificity in differentiating PSP from HC and PD. Prolonged horizontal gaze latency was associated with more severe PSP and worse global cognitive and frontal dysfunction. ALO and reflex blepharospasm were only seen in PSP.
Conclusion
VOG is useful for confirming slow saccades in PSP-RS and PSP-P and in differentiating PSP-P from PD. Prolonged horizontal gaze latency was associated with more severe PSP and worse cognitive dysfunction. ALO and reflex blepharospasm were seen only in PSP.

Asymptomatic Hearing Impairment Frequently Occurs in Early-Onset Parkinson’s Disease: Kuldeep Shetty, Syam Krishnan, Jissa Vinoda Thulaseedharan, Manju Mohan, Asha Kishore; J Mov Disord. 2019;12(2):84-90. Published online April 5, 2019; DOI: https://doi.org/10.14802/jmd.18048

14,497 View
282 Download
21 Web of Science
17 Crossref

Abstract PDF

Objective
Recent reports of hearing impairment in Parkinson’s disease (PD) have suggested that auditory dysfunction could be a non-motor manifestation of PD. These reports were based on observations of elderly patients for whom presbycusis may, to some extent, have contributed to hearing dysfunction. Therefore, we aimed to explore the auditory functions in younger patients with PD. Methods We conducted a case-control study in a relatively younger (< 55 years of age at study time) population of PD patients and healthy volunteers to test whether auditory dysfunction is a significant non-motor dysfunction in PD. Pure tone audiometry (PTA) and brainstem evoked response audiometry (BERA) were performed in all participants. Results None of the patients or controls reported hearing deficits. Fifty-one patients with PD and 50 healthy volunteers who were age- and gender-matched to the patients participated. PTA-detected hearing impairment was found in 64.7% of patients and 28% of controls (p < 0.001) for both low-mid and/or high frequencies. Hearing impairment was more frequent in the younger subgroups of patients than age-matched controls, while the frequency of hearing impairment was similar in older groups of subjects. BERA was not different between patients and controls. Conclusion Asymptomatic auditory dysfunction is a common non-motor manifestation of early-onset PD and more frequent in younger patients, indicating that it may be independent of aging. The mechanism underlying this dysfunction appears to be peripheral, although a central dysfunction cannot be ruled out based on the findings of this study.

Citations

Citations to this article as recorded by

Hearing dysfunction heralds an increase in non-motor burden and a worse quality of life in Parkinson’s disease: new insights from non-motor spectrum
Elena Garasto, Alessandro Stefani, Mariangela Pierantozzi, Matteo Conti, Arturo Moleti, Renata Sisto, Andrea Viziano, Claudio Liguori, Tommaso Schirinzi, Nicola Biagio Mercuri, Rocco Cerroni
Neurological Sciences.2024; 45(9): 4299. CrossRef
Relationship of Hearing Loss to Parkinson’s Disease, Dementia, and APOE Genotype in Adults
Chih-Hung Cha, Tsu-Kung Lin, Ching-Nung Wu, Chao-Hui Yang, Yi-Wen Huang, Chung-Feng Hwang
Medicina.2024; 60(5): 703. CrossRef
Disturbance in the protein landscape of cochlear perilymph in an Alzheimer’s disease mouse model
Masatoshi Fukuda, Hiroki Okanishi, Daisuke Ino, Kazuya Ono, Satoru Kawamura, Eri Wakai, Tsuyoshi Miyoshi, Takashi Sato, Yumi Ohta, Takashi Saito, Takaomi C. Saido, Hidenori Inohara, Yoshikatsu Kanai, Hiroshi Hibino, Abdelwahab Omri
PLOS ONE.2024; 19(5): e0303375. CrossRef
Peripheral hearing in Parkinson’s disease: a systematic review
Mariana S. Leme, Seisse G. G. Sanches, Renata M. M. Carvallo
International Journal of Audiology.2023; 62(9): 805. CrossRef
(Zu-)Hören mit alterndem Gehirn – eine kognitive Herausforderung
Wilma Großmann
Laryngo-Rhino-Otologie.2023; 102(S 01): S12. CrossRef
Is Hearing Loss a Risk Factor for Idiopathic Parkinson’s Disease? An English Longitudinal Study of Ageing Analysis
Megan Rose Readman, Fang Wan, Ian Fairman, Sally A. Linkenauger, Trevor J. Crawford, Christopher J. Plack
Brain Sciences.2023; 13(8): 1196. CrossRef
Hearing Loss and Disorders: The Repercussions of Climate Change
Sue Sherratt
American Journal of Audiology.2023; 32(4): 793. CrossRef
Association between hearing sensitivity and dopamine transporter availability in Parkinson’s disease
Elena Garasto, Alessandro Stefani, Mariangela Pierantozzi, Rocco Cerroni, Matteo Conti, Simone Maranesi, Nicola B Mercuri, Agostino Chiaravalloti, Orazio Schillaci, Andrea Viziano, Arturo Moleti, Renata Sisto
Brain Communications.2023;[Epub] CrossRef
The Anatomy and Clinical Significance of Sensory Disturbance in Parkinson's Disease
Benxu Ma, Jianying Zhang, Yanlei Cui, Huanmin Gao
Journal of Integrative Neuroscience.2023;[Epub] CrossRef
Identifying Parkinson Risk Markers in Primary Care—Old Associations and New Insights
Bhavana Patel, Shannon Chiu, Melissa J. Armstrong
JAMA Neurology.2022; 79(4): 331. CrossRef
Assessment of Risk Factors and Early Presentations of Parkinson Disease in Primary Care in a Diverse UK Population
Cristina Simonet, Jonathan Bestwick, Mark Jitlal, Sheena Waters, Aaron Ben-Joseph, Charles R. Marshall, Ruth Dobson, Soha Marrium, John Robson, Benjamin M. Jacobs, Daniel Belete, Andrew J. Lees, Gavin Giovannoni, Jack Cuzick, Anette Schrag, Alastair J. No
JAMA Neurology.2022; 79(4): 359. CrossRef
Auditory impairment in H‐ABC tubulinopathy
Alejandra Lopez‐Juarez, Arturo Gonzalez‐Vega, Anke Kleinert‐Altamirano, Valeria Piazza, Angeles Garduno‐Robles, Milvia Alata, Carlos Villaseñor‐Mora, Jose R. Eguibar, Carmen Cortes, Luis Carlos Padierna, Victor H. Hernandez
Journal of Comparative Neurology.2021; 529(5): 957. CrossRef
The Effect of Parkinson's Disease on Otoacoustic Emissions and Efferent Suppression of Transient Evoked Otoacoustic Emissions
Evelien De Groote, Annelies Bockstael, Dick Botteldooren, Patrick Santens, Miet De Letter
Journal of Speech, Language, and Hearing Research.2021; 64(4): 1354. CrossRef
Hearing Loss in Neurological Disorders
Siyu Li, Cheng Cheng, Ling Lu, Xiaofeng Ma, Xiaoli Zhang, Ao Li, Jie Chen, Xiaoyun Qian, Xia Gao
Frontiers in Cell and Developmental Biology.2021;[Epub] CrossRef
Age-Related Changes in the Cochlea and Vestibule: Shared Patterns and Processes
Vasiliki Paplou, Nick M. A. Schubert, Sonja J. Pyott
Frontiers in Neuroscience.2021;[Epub] CrossRef
Auditory Dysfunction in Parkinson's Disease
Zahra Jafari, Bryan E. Kolb, Majid H. Mohajerani
Movement Disorders.2020; 35(4): 537. CrossRef
Future Perspectives on the Relevance of Auditory Markers in Prodromal Parkinson's Disease
Evelien De Groote, Kim De Keyser, Patrick Santens, Durk Talsma, Annelies Bockstael, Dick Botteldooren, Miet De Letter
Frontiers in Neurology.2020;[Epub] CrossRef

First
Prev
Page of 1
Next
Last

Search