Skip Navigation
Skip to contents

JMD : Journal of Movement Disorders

OPEN ACCESS
SEARCH
Search
Advanced Search
mobile menu button

Most cited

Page Path
HOME > Browse Articles > Most cited
328 Most cited
Filter
Filter
Article category
More +
Keywords
More +
Publication year
More +
Authors
More +
Funded articles
More +
Cited by list download Download
Review Articles
Functional Neuroanatomy for Posture and Gait Control
Kaoru Takakusaki
J Mov Disord. 2017;10(1):1-17.   Published online January 18, 2017
DOI: https://doi.org/10.14802/jmd.16062
  • 62,197 View
  • 4,124 Download
  • 380 Citations
AbstractAbstract PDF
Here we argue functional neuroanatomy for posture- gait control. Multi-sensory information such as somatosensory, visual and vestibular sensation act on various areas of the brain so that adaptable posture- gait control can be achieved. Automatic process of gait, which is steady-state stepping movements associating with postural reflexes including headeye coordination accompanied by appropriate alignment of body segments and optimal level of postural muscle tone, is mediated by the descending pathways from the brainstem to the spinal cord. Particularly, reticulospinal pathways arising from the lateral part of the mesopontine tegmentum and spinal locomotor network contribute to this process. On the other hand, walking in unfamiliar circumstance requires cognitive process of postural control, which depends on knowledges of self-body, such as body schema and body motion in space. The cognitive information is produced at the temporoparietal association cortex, and is fundamental to sustention of vertical posture and construction of motor programs. The programs in the motor cortical areas run to execute anticipatory postural adjustment that is optimal for achievement of goal-directed movements. The basal ganglia and cerebellum may affect both the automatic and cognitive processes of posturegait control through reciprocal connections with the brainstem and cerebral cortex, respectively. Consequently, impairments in cognitive function by damages in the cerebral cortex, basal ganglia and cerebellum may disturb posture-gait control, resulting in falling.

Citations

Citations to this article as recorded by  
  • Young adults who improve performance during dual-task walking show more flexible reallocation of cognitive resources: a mobile brain-body imaging (MoBI) study
    Eleni Patelaki, John J Foxe, Kevin A Mazurek, Edward G Freedman
    Cerebral Cortex.2023; 33(6): 2573.     CrossRef
  • Midfrontal theta dynamics index the monitoring of postural stability
    Mitchel Stokkermans, Teodoro Solis-Escalante, Michael X Cohen, Vivian Weerdesteyn
    Cerebral Cortex.2023; 33(7): 3454.     CrossRef
  • The Instrumented Stand and Walk (ISAW) test to predict falls in older men
    Fay B. Horak, Amy Laird, Patricia Carlson-Kuhta, Melanie Abrahamson, Martina Mancini, Eric S. Orwoll, Jodi A. Lapidus, Vrutangkumar V. Shah
    GeroScience.2023; 45(2): 823.     CrossRef
  • Turning and multitask gait unmask gait disturbance in mild‐to‐moderate multiple sclerosis: Underlying specific cortical thinning and connecting fibers damage
    Qingmeng Chen, Takaaki Hattori, Hiroshi Tomisato, Masahiro Ohara, Kosei Hirata, Takanori Yokota
    Human Brain Mapping.2023; 44(3): 1193.     CrossRef
  • Altered brain function in patients with vestibular migraine: a study on resting state functional connectivity
    Zhengwei Chen, Liangqun Rong, Lijie Xiao, Quan Wang, Yueji Liu, Cunxin Lin, Jianing Wang, Haiyan Liu, Xiu-e Wei
    Neuroradiology.2023; 65(3): 579.     CrossRef
  • Assessment of balance in people with mild traumatic brain injury using a balance systems model approach
    Kody R. Campbell, Kathleen T. Scanlan, Jennifer L. Wilhelm, Barbara H. Brumbach, Natalie C. Pettigrew, Akira Neilson, Lucy Parrington, Laurie A. King
    Gait & Posture.2023; 100: 107.     CrossRef
  • Relationship between lower limb muscle activity and cortical activation among elderly people during walking: Effects of fast speed and cognitive dual task
    Jinuk Kim, Jungsoo Lee, Gihyoun Lee, Won Hyuk Chang, Myoung-Hwan Ko, Woo-Kyoung Yoo, Gyu-Ha Ryu, Yun-Hee Kim
    Frontiers in Aging Neuroscience.2023;[Epub]     CrossRef
  • Mental states and personality based on real-time physical activity and facial expression recognition
    Yating Huang, Dengyue Zhai, Jingze Song, Xuanheng Rao, Xiao Sun, Jin Tang
    Frontiers in Psychiatry.2023;[Epub]     CrossRef
  • Sensorimotor recalibration of postural control strategies occurs after whole body vibration
    Isotta Rigoni, Giulio Degano, Mahmoud Hassan, Antonio Fratini
    Scientific Reports.2023;[Epub]     CrossRef
  • A neuroergonomic approach to assessing motor performance in stroke patients using fNIRS and behavioral data
    Lingguo Bu, Jing Qu, Lei Zhao, Yanjie Zhang, Yonghui Wang
    Applied Ergonomics.2023; 109: 103979.     CrossRef
  • Case report: A novel approach of closed-loop brain stimulation combined with robot gait training in post-stroke gait disturbance
    Atsushi Shima, Tomoaki Miyake, Kazuki Tanaka, Akari Ogawa, Erika Omae, Yui Nagamori, Yusuke Miyata, Koji Ohata, Takakuni Maki, Yumie Ono, Tatsuya Mima, Ryosuke Takahashi, Satoko Koganemaru
    Frontiers in Human Neuroscience.2023;[Epub]     CrossRef
  • Cognitive and emotional factors influence specific domains of postural control in individuals with moderate-to-severe Parkinson’s disease
    Claudia Eunice Neves de Oliveira, Daniel Boari Coelho, Caroline Ribeiro de Souza, Alana Xavier Batista, Raquel Marquesini, Acácio Moreira-Neto, Carla Silva-Batista, Adriana Tanigawa Bitiati, Luis Augusto Teixeira, Andrea Cristina de Lima-Pardini
    Gait & Posture.2023; 101: 66.     CrossRef
  • Developmental changes in straight gait in childhood
    Saori Miyagishima, Hiroki Mani, Yui Sato, Takahiro Inoue, Tadayoshi Asaka, Naoki Kozuka, Dimitrios Sokratis Komaris
    PLOS ONE.2023; 18(2): e0281037.     CrossRef
  • Case report: Backward gait training combined with gait-synchronized cerebellar transcranial alternating current stimulation in progressive supranuclear palsy
    Atsushi Shima, Kazuki Tanaka, Akari Ogawa, Erika Omae, Tomoaki Miyake, Yui Nagamori, Yusuke Miyata, Koji Ohata, Yumie Ono, Tatsuya Mima, Ryosuke Takahashi, Satoko Koganemaru
    Frontiers in Human Neuroscience.2023;[Epub]     CrossRef
  • Cerebellar Transcranial Direct Current Stimulation Modulates Anticipatory Postural Adjustments in Healthy Adults
    Haian Mao, Wenwu Xiao, Zengming Hao, Shengjun Wen, Huaichun Yang, Fahad Sultan, Chuhuai Wang
    The Cerebellum.2023;[Epub]     CrossRef
  • Model of Gait Control in Parkinson’s Disease and Prediction of Robotic Assistance
    Clémence Vandamme, Virginie Otlet, Renaud Ronsse, Frédéric Crevecoeur
    IEEE Transactions on Neural Systems and Rehabilitation Engineering.2023; 31: 1374.     CrossRef
  • Sex-specific differences in resting-state functional brain activity in pediatric concussion
    Bhanu Sharma, Cameron Nowikow, Carol DeMatteo, Michael D. Noseworthy, Brian W. Timmons
    Scientific Reports.2023;[Epub]     CrossRef
  • Pain and Parkinson's disease: Current mechanism and management updates
    Frederic J. F. Viseux, Arnaud Delval, Martin Simoneau, Luc Defebvre
    European Journal of Pain.2023; 27(5): 553.     CrossRef
  • Increased Effective Connectivity of the Left Parietal Lobe During Walking Tasks in Parkinson’s Disease
    Yue Wang, Ningbo Yu, Jiewei Lu, Xinyuan Zhang, Jin Wang, Zhilin Shu, Yuanyuan Cheng, Zhizhong Zhu, Yang Yu, Peipei Liu, Jianda Han, Jialing Wu
    Journal of Parkinson's Disease.2023; 13(2): 165.     CrossRef
  • Imagined Timed Up and Go test (iTUG) in people with Parkinson’s Disease: test-retest reliability and validity
    Marcos Moreno-Verdú, María del Rosario Ferreira-Sánchez, Patricia Martín-Casas, María Ángeles Atín-Arratibel
    Disability and Rehabilitation.2023; : 1.     CrossRef
  • Cortical oscillations and interareal synchronization as a preparatory activity for postural response
    Kimiya Fujio, Hiroki Obata, Kenta Takeda, Noritaka Kawashima
    European Journal of Neuroscience.2023; 57(9): 1516.     CrossRef
  • Effects of wearable visual cueing on gait pattern and stability in patients with Parkinson’s disease
    Wei Zhang, Yun Han, Yuanyuan Shi, Shilei Yan, Wenjing Song, Guiyun Cui, Jie Xiang
    Frontiers in Neurology.2023;[Epub]     CrossRef
  • Modulating arousal to overcome gait impairments in Parkinson’s disease: how the noradrenergic system may act as a double-edged sword
    Anouk Tosserams, Bastiaan R. Bloem, Kaylena A. Ehgoetz Martens, Rick C. Helmich, Roy P. C. Kessels, James M. Shine, Natasha L. Taylor, Gabriel Wainstein, Simon J. G. Lewis, Jorik Nonnekes
    Translational Neurodegeneration.2023;[Epub]     CrossRef
  • Contrôle central de l’équilibre et prévention des chutes : impact sur la rééducation
    A.P. Yelnik
    Bulletin de l'Académie Nationale de Médecine.2023; 207(5): 649.     CrossRef
  • Cortical thickness is related to cognitive-motor automaticity and attention allocation in individuals with Alzheimer’s disease: a regions of interest study
    Jason K. Longhurst, Karthik R. Sreenivasan, Jemma Kim, Jeffrey L. Cummings, Samantha E. John, Brach Poston, Dietmar Cordes, John V. Rider, Merrill R. Landers
    Experimental Brain Research.2023; 241(6): 1489.     CrossRef
  • Structural-Functional Correlates of Response to Pedunculopontine Stimulation in a Randomized Clinical Trial for Axial Symptoms of Parkinson’s Disease
    Sorin Breit, Luka Milosevic, Georgios Naros, Idil Cebi, Daniel Weiss, Alireza Gharabaghi
    Journal of Parkinson's Disease.2023; : 1.     CrossRef
  • Interrelation between functional decline and dementia: The potential role of balance assessment
    Francesca Biasin, Chiara Ceolin, Silvia Celli, Camilla Terziotti, Cecilia Raffaelli, Cristiano Bontempi, Maria Devita, Marina De Rui, Giuseppe Sergi, Alessandra Coin
    Human Movement Science.2023; 89: 103095.     CrossRef
  • Trend Change Analysis as a New Tool to Complement the Evaluation of Human Body Balance in the Time and Frequency Domains
    Piotr Wodarski
    Journal of Human Kinetics.2023;[Epub]     CrossRef
  • Neural underpinnings of freezing-related dynamic balance control in people with Parkinson's disease
    Bauke W. Dijkstra, Moran Gilat, Nicholas D'Cruz, Demi Zoetewei, Alice Nieuwboer
    Parkinsonism & Related Disorders.2023; 112: 105444.     CrossRef
  • Electrocortical Dynamics of Usual Walking and the Planning to Step over Obstacles in Parkinson’s Disease
    Rodrigo Vitório, Ellen Lirani-Silva, Diego Orcioli-Silva, Victor Spiandor Beretta, Anderson Souza Oliveira, Lilian Teresa Bucken Gobbi
    Sensors.2023; 23(10): 4866.     CrossRef
  • Mental fatigue does not affect static balance under both single and dual task conditions in young adults
    Abubakar Tijjani Salihu, Jibrin Sammani Usman, Keith D. Hill, Maryam Zoghi, Shapour Jaberzadeh
    Experimental Brain Research.2023;[Epub]     CrossRef
  • Contribution of neural circuits tested by transcranial magnetic stimulation in corticomotor control of low back muscle: a systematic review
    Mikaël Desmons, Michael Theberge, Catherine Mercier, Hugo Massé-Alarie
    Frontiers in Neuroscience.2023;[Epub]     CrossRef
  • Separated center-of-pressure measurements reveal new characteristics of reduced anticipatory postural adjustments during gait initiation in patients with Parkinson’s disease
    Ryo Onuma, Tadashi Masuda, Fumihiko Hoshi, Tadamitsu Matsuda, Tomoko Sakai, Atsushi Okawa, Tetsuya Jinno
    Physiotherapy Theory and Practice.2022; 38(13): 2544.     CrossRef
  • Kyphosis and bizarre patterns impair spontaneous gait performance in end-of-life mice with Alzheimer's disease pathology while gait is preserved in normal aging
    Lidia Castillo-Mariqueo, Lydia Giménez-Llort
    Neuroscience Letters.2022; 767: 136280.     CrossRef
  • Brain network topology and future development of freezing of gait in Parkinson’s disease: a longitudinal study
    Nannan Li, Du Lei, Jiaxin Peng, Xueling Suo, Junying Li, Liren Duan, Chaolan Chen, Qiyong Gong, Rong Peng
    Journal of Neurology.2022; 269(5): 2503.     CrossRef
  • Changes of cerebral network activity after invasive stimulation of the mesencephalic locomotor region in a rat stroke model
    Stefanie D. Krämer, Michael K. Schuhmann, Fabian Schadt, Ina Israel, Samuel Samnick, Jens Volkmann, Felix Fluri
    Experimental Neurology.2022; 347: 113884.     CrossRef
  • Neuroticism and Extraversion Are Related to Changes in Postural Stability During Anatomically-Related Cognitive Tasks
    Christopher I. Higginson, Marisa Valenti, Karlie Ibrahim, Brian A. Knarr, Rob Ryan, Jill S. Higginson
    Journal of Motor Behavior.2022; 54(4): 401.     CrossRef
  • Wide-Field Calcium Imaging of Dynamic Cortical Networks during Locomotion
    Sarah L West, Justin D Aronson, Laurentiu S Popa, Kathryn D Feller, Russell E Carter, William M Chiesl, Morgan L Gerhart, Aditya C Shekhar, Leila Ghanbari, Suhasa B Kodandaramaiah, Timothy J Ebner
    Cerebral Cortex.2022; 32(12): 2668.     CrossRef
  • Longitudinal Relation Between Structural Network Efficiency, Cognition, and Gait in Cerebral Small Vessel Disease
    Mengfei Cai, Mina A Jacob, David G Norris, Frank-Erik de Leeuw, Anil M Tuladhar, Lewis A Lipsitz
    The Journals of Gerontology: Series A.2022; 77(3): 554.     CrossRef
  • Presence Hallucinations during Locomotion in Patients with Parkinson's Disease
    Jevita Potheegadoo, Herberto Dhanis, Judit Horvath, Pierre R. Burkhard, Olaf Blanke
    Movement Disorders Clinical Practice.2022; 9(1): 127.     CrossRef
  • Whole-body vibration exercise and training increase regional CBF in mild cognitive impairment with enhanced cognitive function
    Ikuo Odano, Fumio Maeyatsu, Mami Asari, Sayaka Yamaguchi, Tsukasa Miura, Yasuyuki Taki
    Annals of Nuclear Medicine.2022; 36(1): 82.     CrossRef
  • Visuomotor errors drive step length and step time adaptation during ‘virtual’ split-belt walking: the effects of reinforcement feedback
    Sumire Sato, Ashley Cui, Julia T. Choi
    Experimental Brain Research.2022; 240(2): 511.     CrossRef
  • Influence of controlled masticatory muscle activity on dynamic reactive balance
    Cagla Fadillioglu, Lisa Kanus, Felix Möhler, Steffen Ringhof, Hans J. Schindler, Thorsten Stein, Daniel Hellmann
    Journal of Oral Rehabilitation.2022; 49(3): 327.     CrossRef
  • Discussion of Research Priorities for Gait Disorders in Parkinson's Disease
    Nicolaas I. Bohnen, Rui M. Costa, William T. Dauer, Stewart A. Factor, Nir Giladi, Mark Hallett, Simon J.G. Lewis, Alice Nieuwboer, John G. Nutt, Kaoru Takakusaki, Un Jung Kang, Serge Przedborski, Stella M. Papa
    Movement Disorders.2022; 37(2): 253.     CrossRef
  • Analysis of the Stability of the Body in a Standing Position When Shooting at a Stationary Target―A Randomized Controlled Trial
    Marlena Krawczyk-Suszek, Blanka Martowska, Rafał Sapuła
    Sensors.2022; 22(1): 368.     CrossRef
  • Gaps and roadmap of novel neuromodulation targets for treatment of gait in Parkinson’s disease
    Rubens Gisbert Cury, Nicola Pavese, Tipu Z. Aziz, Joachim K. Krauss, Elena Moro
    npj Parkinson's Disease.2022;[Epub]     CrossRef
  • The Influence of Aging on the Functional Connectivity of the Human Basal Ganglia
    Clara Rodriguez-Sabate, Ingrid Morales, Manuel Rodriguez
    Frontiers in Aging Neuroscience.2022;[Epub]     CrossRef
  • Effects of task prioritization on a postural-motor task in early-stage Parkinson’s disease: EEG connectivity and clinical implication
    Cheng-Ya Huang, Liang-Chi Chen, Ruey-Meei Wu, Ing-Shiou Hwang
    GeroScience.2022; 44(4): 2061.     CrossRef
  • Effect of cognitive task complexity on dual task postural stability: a systematic review and meta-analysis
    Abubakar Tijjani Salihu, Keith D. Hill, Shapour Jaberzadeh
    Experimental Brain Research.2022; 240(3): 703.     CrossRef
  • Targeting Sensory and Motor Integration for Recovery of Movement After CNS Injury
    Ahmet S. Asan, James R. McIntosh, Jason B. Carmel
    Frontiers in Neuroscience.2022;[Epub]     CrossRef
  • Increased prefrontal activity during usual walking in aging
    I. Hoang, L. Paire-Ficout, R. Derollepot, S. Perrey, H. Devos, M. Ranchet
    International Journal of Psychophysiology.2022; 174: 9.     CrossRef
  • Effects of sling exercise therapy on post-stroke walking impairment: a systematic review and meta-analysis
    Junzi Long, Yasu Zhang, Xiaomin Liu, Xiaoqin Jin
    International Journal of Rehabilitation Research.2022; 45(1): 12.     CrossRef
  • Electromyographic responses to unexpected Achilles tendon vibration-induced perturbations during standing in young and older people
    Anastasia Papavasileiou, Lida Mademli, Vassilia Hatzitaki, Dimitrios A. Patikas
    Experimental Brain Research.2022; 240(4): 1017.     CrossRef
  • Do physical activity, cardiorespiratory fitness, and subcortical brain structures explain reduced walking performance in older adults with multiple sclerosis?
    Jessica F. Baird, Gary R. Cutter, Robert W. Motl
    Multiple Sclerosis and Related Disorders.2022; 60: 103702.     CrossRef
  • Gait and posture are correlated domains in Parkinson’s disease
    Thaisy Moraes Costa, Lucas Simieli, Felipe Marrese Bersotti, Luis Mochizuki, Fabio Augusto Barbieri, Daniel Boari Coelho
    Neuroscience Letters.2022; 775: 136537.     CrossRef
  • Why Should Constant Stimulation of Saccular Afferents Modify the Posture and Gait of Patients with Bilateral Vestibular Dysfunction? The Saccular Substitution Hypothesis
    Ian S. Curthoys, Paul F. Smith, Angel Ramos de Miguel
    Journal of Clinical Medicine.2022; 11(4): 1132.     CrossRef
  • A Neural Controller Model Considering the Vestibulospinal Tract in Human Postural Control
    Yuichiro Omura, Kohei Kaminishi, Ryosuke Chiba, Kaoru Takakusaki, Jun Ota
    Frontiers in Computational Neuroscience.2022;[Epub]     CrossRef
  • Fear of Falling Does Not Influence Dual-Task Gait Costs in People with Parkinson’s Disease: A Cross-Sectional Study
    Tino Prell, Manuela Uhlig, Steffen Derlien, Walter Maetzler, Hannah M. Zipprich
    Sensors.2022; 22(5): 2029.     CrossRef
  • Dynamics of cortical and corticomuscular connectivity during planning and execution of visually guided steps in humans
    Meaghan E Spedden, Mikkel M Beck, Timothy O West, Simon F Farmer, Jens B Nielsen, Jesper Lundbye-Jensen
    Cerebral Cortex.2022; 33(2): 258.     CrossRef
  • Combined Subthalamic and Nigral Stimulation Modulates Temporal Gait Coordination and Cortical Gait-Network Activity in Parkinson’s Disease
    Jonas R. Wagner, Miriam Schaper, Wolfgang Hamel, Manfred Westphal, Christian Gerloff, Andreas K. Engel, Christian K. E. Moll, Alessandro Gulberti, Monika Pötter-Nerger
    Frontiers in Human Neuroscience.2022;[Epub]     CrossRef
  • Variability of Postural Stability and Plantar Pressure Parameters in Healthy Subjects Evaluated by a Novel Pressure Plate
    Allegra Fullin, Paolo Caravaggi, Pietro Picerno, Massimiliano Mosca, Silvio Caravelli, Antonio De Luca, Angela Lucariello, Paolo De Blasiis
    International Journal of Environmental Research and Public Health.2022; 19(5): 2913.     CrossRef
  • How Does the Central Nervous System for Posture and Locomotion Cope With Damage-Induced Neural Asymmetry?
    Didier Le Ray, Mathias Guayasamin
    Frontiers in Systems Neuroscience.2022;[Epub]     CrossRef
  • Rodent models for gait network disorders in Parkinson's disease – a translational perspective
    Nikolaus Wenger, Arend Vogt, Matej Skrobot, Elisa L. Garulli, Burce Kabaoglu, Christina Salchow-Hömmen, Thomas Schauer, Daniel Kroneberg, Michael K. Schuhmann, Chi Wang Ip, Christoph Harms, Matthias Endres, Ioannis U. Isaias, Philip Tovote, Robert Blum
    Experimental Neurology.2022; 352: 114011.     CrossRef
  • Transcutaneous spinal stimulation alters cortical and subcortical activation patterns during mimicked-standing: A proof-of-concept fMRI study
    Gerome A. Manson, Darryn A. Atkinson, Zhaoyue Shi, Jony Sheynin, Christof Karmonik, Rachel L. Markley, Dimitry G. Sayenko
    Neuroimage: Reports.2022; 2(2): 100090.     CrossRef
  • Differential Relationships Between Brain Structure and Dual Task Walking in Young and Older Adults
    Kathleen E. Hupfeld, Justin M. Geraghty, Heather R. McGregor, C. J. Hass, Ofer Pasternak, Rachael D. Seidler
    Frontiers in Aging Neuroscience.2022;[Epub]     CrossRef
  • What Is the Brainstem Control of Locomotion?
    Farwa Ali, Eduardo Benarroch
    Neurology.2022; 98(11): 446.     CrossRef
  • The emerging postural instability phenotype in idiopathic Parkinson disease
    Frank M. Skidmore, William S. Monroe, Christopher P. Hurt, Anthony P. Nicholas, Adam Gerstenecker, Thomas Anthony, Leon Jololian, Gary Cutter, Adil Bashir, Thomas Denny, David Standaert, Elizabeth A. Disbrow
    npj Parkinson's Disease.2022;[Epub]     CrossRef
  • Brain Activation During Active Balancing and Its Behavioral Relevance in Younger and Older Adults: A Functional Near-Infrared Spectroscopy (fNIRS) Study
    Nico Lehmann, Yves-Alain Kuhn, Martin Keller, Norman Aye, Fabian Herold, Bogdan Draganski, Wolfgang Taube, Marco Taubert
    Frontiers in Aging Neuroscience.2022;[Epub]     CrossRef
  • Influence of Controlled Stomatognathic Motor Activity on Sway, Control and Stability of the Center of Mass During Dynamic Steady-State Balance—An Uncontrolled Manifold Analysis
    Cagla Fadillioglu, Lisa Kanus, Felix Möhler, Steffen Ringhof, Daniel Hellmann, Thorsten Stein
    Frontiers in Human Neuroscience.2022;[Epub]     CrossRef
  • Frequency‐dependent modulation of neural oscillations across the gait cycle
    Mingqi Zhao, Gaia Bonassi, Jessica Samogin, Gaia Amaranta Taberna, Elisa Pelosin, Alice Nieuwboer, Laura Avanzino, Dante Mantini
    Human Brain Mapping.2022; 43(11): 3404.     CrossRef
  • Gait subgroups among older adults with chronic pain differ in cerebellum and basal ganglia gray matter volumes
    Ania L. Lipat, David J. Clark, Chris J. Hass, Yenisel Cruz-Almeida
    Experimental Gerontology.2022; 163: 111773.     CrossRef
  • Restorative Action of Vitamin D3 on Motor Dysfunction Through Enhancement of Neurotrophins and Antioxidant Expression in the Striatum
    S.K.V. Manjari, Shuvadeep Maity, R. Poornima, Suk-Yu Yau, K. Vaishali, David Stellwagen, Pragya Komal
    Neuroscience.2022; 492: 67.     CrossRef
  • Consensus Paper: Ataxic Gait
    Pierre Cabaraux, Sunil K. Agrawal, Huaying Cai, Rocco Salvatore Calabro, Carlo Casali, Loic Damm, Sarah Doss, Christophe Habas, Anja K. E. Horn, Winfried Ilg, Elan D. Louis, Hiroshi Mitoma, Vito Monaco, Maria Petracca, Alberto Ranavolo, Ashwini K. Rao, Se
    The Cerebellum.2022; 22(3): 394.     CrossRef
  • Body Representation in Patients with Severe Spinal Cord Injury: A Pilot Study on the Promising Role of Powered Exoskeleton for Gait Training
    Maria Grazia Maggio, Antonino Naro, Rosaria De Luca, Desiree Latella, Tina Balletta, Lory Caccamo, Giovanni Pioggia, Daniele Bruschetta, Rocco Salvatore Calabrò
    Journal of Personalized Medicine.2022; 12(4): 619.     CrossRef
  • Parkinson’s Disease Symptoms Associated with Developing On-State Axial Symptoms Early after Subthalamic Deep Brain Stimulation
    Gustavo Fernández-Pajarín, Ángel Sesar, José Luis Relova, Begoña Ares, Isabel Jiménez, Miguel Gelabert-González, Eduardo Arán, Alfonso Castro
    Diagnostics.2022; 12(4): 1001.     CrossRef
  • Glycation modulates glutamatergic signaling and exacerbates Parkinson’s disease-like phenotypes
    Ana Chegão, Mariana Guarda, Bruno M. Alexandre, Liana Shvachiy, Mariana Temido-Ferreira, Inês Marques-Morgado, Bárbara Fernandes Gomes, Rune Matthiesen, Luísa V. Lopes, Pedro R. Florindo, Ricardo A. Gomes, Patrícia Gomes-Alves, Joana E. Coelho, Tiago Flem
    npj Parkinson's Disease.2022;[Epub]     CrossRef
  • The Association Between Gait Speed and Sleep Problems Among Chinese Adults Aged 50 and Greater
    Lili Wang, Benxu Zou
    Frontiers in Neuroscience.2022;[Epub]     CrossRef
  • Effect of optokinetic virtual reality scenes on a sitting-to-stand movement
    Akkradate Siriphorn, Chachane Jarudej, Nuttapong Ochaklin, Sarunyou Nuttawanlop, Theerapan Prasertteerapong
    Human Movement Science.2022; 83: 102956.     CrossRef
  • Neurophysiological mechanisms of gait disturbance in advanced Parkinson's disease patients
    Kaoru Takakusaki, Mirai Takahashi, Tomohiro Noguchi, Ryosuke Chiba
    Neurology and Clinical Neuroscience.2022;[Epub]     CrossRef
  • Is Balance Control Affected by Sleep Deprivation? A Systematic Review of the Impact of Sleep on the Control of Balance
    Guilherme Silva Umemura, Fabianne Furtado, Fabia Camile dos Santos, Bruno da Silva Brandão Gonçalves, Arturo Forner-Cordero
    Frontiers in Neuroscience.2022;[Epub]     CrossRef
  • Troubleshooting Gait Disturbances in Parkinson’s Disease With Deep Brain Stimulation
    Nicoló G. Pozzi, Chiara Palmisano, Martin M. Reich, Philip Capetian, Claudio Pacchetti, Jens Volkmann, Ioannis U. Isaias
    Frontiers in Human Neuroscience.2022;[Epub]     CrossRef
  • The functional and structural neural correlates of dynamic balance impairment and recovery in persons with acquired brain injury
    Katherin Joubran, Simona Bar-Haim, Lior Shmuelof
    Scientific Reports.2022;[Epub]     CrossRef
  • Motor imagery in amyotrophic lateral Sclerosis: An fMRI study of postural control
    Malek Abidi, Pierre-Francois Pradat, Nicolas Termoz, Annabelle Couillandre, Peter Bede, Giovanni de Marco
    NeuroImage: Clinical.2022; 35: 103051.     CrossRef
  • Brain and muscle activation patterns during postural control affect static postural control
    Ken Kumai, Yumi Ikeda, Katsuya Sakai, Keisuke Goto, Kenji Morikawa, Keiichirou Shibata
    Gait & Posture.2022; 96: 102.     CrossRef
  • Decoding neural activity preceding balance loss during standing with a lower-limb exoskeleton using an interpretable deep learning model
    Akshay Sujatha Ravindran, Christopher A Malaya, Isaac John, Gerard E Francisco, Charles Layne, Jose L Contreras-Vidal
    Journal of Neural Engineering.2022; 19(3): 036015.     CrossRef
  • Free-living gait does not differentiate chronic mTBI patients compared to healthy controls
    Dylan Powell, Alan Godfrey, Lucy Parrington, Kody R. Campbell, Laurie A. King, Sam Stuart
    Journal of NeuroEngineering and Rehabilitation.2022;[Epub]     CrossRef
  • The “Hand as Foot” teaching method in anatomy of the inner ear
    Meng Xu, Feifei Zhao, Yanlin Chen, Xiaobo Zhu
    Asian Journal of Surgery.2022; 45(11): 2451.     CrossRef
  • Assessing Neurokinematic and Neuromuscular Connectivity During Walking Using Mobile Brain-Body Imaging
    Mingqi Zhao, Gaia Bonassi, Jessica Samogin, Gaia Amaranta Taberna, Camillo Porcaro, Elisa Pelosin, Laura Avanzino, Dante Mantini
    Frontiers in Neuroscience.2022;[Epub]     CrossRef
  • Stabilometric Biofeedback Training in Cognitive and Affective Function Improvement. Contribution of the Russian Scientific School. Part II
    O. M. Bazanova, A. V. Kovaleva
    Human Physiology.2022; 48(3): 271.     CrossRef
  • Gait analysis under the lens of statistical physics
    Massimiliano Zanin, Felipe Olivares, Irene Pulido-Valdeolivas, Estrella Rausell, David Gomez-Andres
    Computational and Structural Biotechnology Journal.2022; 20: 3257.     CrossRef
  • Role of primary motor cortex in gait: automatic-voluntary dissociation seen in paretic leg of a patient who had a stroke
    Masanori Nagaoka, Yasuhiro Kumakura, Katsuyuki Inaba, Akira Ebihara, Miyu Usui
    BMJ Neurology Open.2022; 4(1): e000275.     CrossRef
  • Reliability and Validity of Mini-Balance Evaluation System Test in Type 2 Diabetic Patients with Peripheral Neuropathy
    Sitt Nyein Phyu, Punnee Peungsuwan, Rungthip Puntumetakul, Uraiwan Chatchawan
    International Journal of Environmental Research and Public Health.2022; 19(11): 6944.     CrossRef
  • Gray Matter Abnormalities in Myotonic Dystrophy Type 1: A Voxel-Wise Meta-Analysis
    Qirui Jiang, Junyu Lin, Chunyu Li, Yanbing Hou, Huifang Shang
    Frontiers in Neurology.2022;[Epub]     CrossRef
  • Association of Cervical Vestibular-Evoked Myogenic Potentials (VEMP) and Postural Instability in Patients with Parkinson’s Disease: A Cross-Sectional Study
    Archana Gaur, Ravichandran Rajamanickam, Chennappan Chinnathambi, Divya Selvaraju, Varatharajan Sakthivadivel
    Annals of Neurosciences.2022; 29(2-3): 137.     CrossRef
  • Neurodegenerative and Cerebrovascular Brain Pathologies Are Differentially Associated With Declining Grip Strength and Gait In Older Adults
    Shahram Oveisgharan, Lei Yu, Tianhao Wang, Julie A Schneider, David A Bennett, Aron S Buchman, Lewis A Lipsitz
    The Journals of Gerontology: Series A.2022;[Epub]     CrossRef
  • Resting state functional networks predict different aspects of postural control in Parkinson’s disease
    Anjanibhargavi Ragothaman, Martina Mancini, John G. Nutt, Damien A. Fair, Oscar Miranda-Dominguez, Fay B. Horak
    Gait & Posture.2022; 97: 122.     CrossRef
  • Cumulative additional information does not improve the neuromuscular control during postural responses to perturbations in postural instability/gait disorders subtype of Parkinson's disease
    Victor Spiandor Beretta, Paulo Cezar Rocha Santos, Diego Orcioli-Silva, Diego Alejandro Rojas Jaimes, Marcelo Pinto Pereira, Fabio Augusto Barbieri, Lilian Teresa Bucken Gobbi
    Experimental Gerontology.2022; 166: 111892.     CrossRef
  • Relation between Cortical Activation and Effort during Robot-Mediated Walking in Healthy People: A Functional Near-Infrared Spectroscopy Neuroimaging Study (fNIRS)
    Julien Bonnal, Fanny Monnet, Ba-Thien Le, Ophélie Pila, Anne-Gaëlle Grosmaire, Canan Ozsancak, Christophe Duret, Pascal Auzou
    Sensors.2022; 22(15): 5542.     CrossRef
  • Association of Genetic Variant Linked to Hemochromatosis With Brain Magnetic Resonance Imaging Measures of Iron and Movement Disorders
    Robert Loughnan, Jonathan Ahern, Cherisse Tompkins, Clare E. Palmer, John Iversen, Wesley K. Thompson, Ole Andreassen, Terry Jernigan, Leo Sugrue, Anders Dale, Mary E. T. Boyle, Chun Chieh Fan
    JAMA Neurology.2022; 79(9): 919.     CrossRef
  • Muscle Strength and Balance as Mediators in the Association between Physical Activity and Health-Related Quality of Life in Community-Dwelling Older Adults
    Marcelo de Maio Nascimento, Bruna R. Gouveia, Élvio Rúbio Gouveia, Pedro Campos, Adilson Marques, Andreas Ihle
    Journal of Clinical Medicine.2022; 11(16): 4857.     CrossRef
  • Spinal cord stimulation therapy for patients with Parkinson’s disease and gait problems (STEP-PD): study protocol for an exploratory, double-blind, randomised, placebo-controlled feasibility trial
    Victor S Hvingelby, Miriam Højholt Terkelsen, Erik L Johnsen, Mette Møller, Erik Hvid Danielsen, Tove Henriksen, Andreas Nørgaard Glud, Yen Tai, Anne Sofie Møller Andersen, Kaare Meier, Per Borghammer, Elena Moro, Jens Christian Hedemann Sørensen, Nicola
    BMJ Neurology Open.2022; 4(2): e000333.     CrossRef
  • Adaptations of postural sway dynamics and cortical response to unstable stance with stroboscopic vision in older adults
    Yi-Ying Tsai, Yi-Ching Chen, Chen-Guang Zhao, Ing-Shiou Hwang
    Frontiers in Physiology.2022;[Epub]     CrossRef
  • Blood pressure changes impact corticospinal integrity and downstream gait and balance control
    Elizabeth A. Coon, Anna M. Castillo, Timothy G. Lesnick, Sheelakumari Raghavan, Michelle M. Mielke, Robert I. Reid, B. Gwen Windham, Ronald C. Petersen, Clifford R. Jack, Jonathan Graff-Radford, Prashanthi Vemuri
    Neurobiology of Aging.2022; 120: 60.     CrossRef
  • Mobile Brain Imaging to Examine Task-Related Cortical Correlates of Reactive Balance: A Systematic Review
    Rudri Purohit, Tanvi Bhatt
    Brain Sciences.2022; 12(11): 1487.     CrossRef
  • Transcranial direct current stimulation for balance rehabilitation in neurological disorders: A systematic review and meta-analysis
    Victor Spiandor Beretta, Paulo Cezar Rocha Santos, Diego Orcioli-Silva, Vinicius Cavassano Zampier, Rodrigo Vitório, Lilian Teresa Bucken Gobbi
    Ageing Research Reviews.2022; 81: 101736.     CrossRef
  • Freezing of gait, gait initiation, and gait automaticity share a similar neural substrate in Parkinson's disease
    Acácio Moreira-Neto, Carlos Ugrinowitsch, Daniel Boari Coelho, Andrea Cristina de Lima-Pardini, Egberto Reis Barbosa, Luis Augusto Teixeira, Edson Amaro, Fay B. Horak, Martina Mancini, Mariana Penteado Nucci, Carla Silva-Batista
    Human Movement Science.2022; 86: 103018.     CrossRef
  • Association between Backward Walking and Cognition in Parkinson Disease: A Systematic Review
    Mathias Baptiste Correno, Clint Hansen, Matthias Chardon, Tracy Milane, Edoardo Bianchini, Nicolas Vuillerme
    International Journal of Environmental Research and Public Health.2022; 19(19): 12810.     CrossRef
  • The Effect of Dual-Task Motor-Cognitive Training in Adults with Neurological Diseases Who Are at Risk of Falling
    Barbara Spanò, Massimo De Tollis, Sara Taglieri, Alice Manzo, Claudia Ricci, Maria G. Lombardi, Lorenzo Polidori, Ivo A. Griffini, Marta Aloisi, Vincenzo Vinicola, Rita Formisano, Carlo Caltagirone, Roberta Annicchiarico
    Brain Sciences.2022; 12(9): 1207.     CrossRef
  • Connecting real-world digital mobility assessment to clinical outcomes for regulatory and clinical endorsement–the Mobilise-D study protocol
    A. Stefanie Mikolaizak, Lynn Rochester, Walter Maetzler, Basil Sharrack, Heleen Demeyer, Claudia Mazzà, Brian Caulfield, Judith Garcia-Aymerich, Beatrix Vereijken, Valdo Arnera, Ram Miller, Paolo Piraino, Nadir Ammour, Mark Forrest Gordon, Thierry Trooste
    PLOS ONE.2022; 17(10): e0269615.     CrossRef
  • Toxicity evaluation induced by single and 28-days repeated exposure of withametelin and daturaolone in Sprague Dawley rats
    Muhammad Waleed Baig, Muhammad Majid, Bakht Nasir, Syed Shams ul Hassan, Simona Bungau, Ihsan-ul Haq
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Cognitive Function and Postural Control Strategies in Relation to Disease Progression in Patients with Parkinson’s Disease
    Monika Zawadka-Kunikowska, Jacek J. Klawe, Małgorzata Tafil-Klawe, Monika Bejtka, Łukasz Rzepiński, Mirosława Cieślicka
    International Journal of Environmental Research and Public Health.2022; 19(19): 12694.     CrossRef
  • Effect of sports background on the visual and vestibular signal processing abilities of athletes
    F. Zsarnoczky-Dulhazi, A. Hegedus, P. Soldos, L. Trzaskoma, B. Kopper
    Science & Sports.2022; 37(8): 798.e1.     CrossRef
  • Abnormal neural oscillations during gait and dual-task in Parkinson’s disease
    Rachel O. Nwogo, Stefan Kammermeier, Arun Singh
    Frontiers in Systems Neuroscience.2022;[Epub]     CrossRef
  • Effects of different virtual reality technology driven dual-tasking paradigms on posture and saccadic eye movements in healthy older adults
    Yu Imaoka, Andri Flury, Laura Hauri, Eling D. de Bruin
    Scientific Reports.2022;[Epub]     CrossRef
  • Principles of gait encoding in the subthalamic nucleus of people with Parkinson’s disease
    Yohann Thenaisie, Kyuhwa Lee, Charlotte Moerman, Stefano Scafa, Andrea Gálvez, Elvira Pirondini, Morgane Burri, Jimmy Ravier, Alessandro Puiatti, Ettore Accolla, Benoit Wicki, André Zacharia, Mayte Castro Jiménez, Julien F. Bally, Grégoire Courtine, Jocel
    Science Translational Medicine.2022;[Epub]     CrossRef
  • Glutamatergic pedunculopontine tegmental neurons control wakefulness and locomotion via distinct axonal projections
    Daniel Kroeger, Jack Thundercliffe, Alex Phung, Roberto De Luca, Carolyn Geraci, Samuel Bragg, Kayleen J McCafferty, Sathyajit S Bandaru, Elda Arrigoni, Thomas E Scammell
    Sleep.2022;[Epub]     CrossRef
  • Exploring Mediation Effects of Gait Speed, Body Balance, and Falls in the Relationship between Physical Activity and Health-Related Quality of Life in Vulnerable Older Adults
    Marcelo de Maio Nascimento, Élvio Rúbio Gouveia, Bruna R. Gouveia, Adilson Marques, Cíntia França, Duarte L. Freitas, Pedro Campos, Andreas Ihle
    International Journal of Environmental Research and Public Health.2022; 19(21): 14135.     CrossRef
  • Fronto-parietal cortex activation during walking in patients with Parkinson's disease adopting different postural strategies
    Xinyuan Zhang, Yue Wang, Jiewei Lu, Jin Wang, Zhilin Shu, Yuanyuan Cheng, Zhizhong Zhu, PeiPei Liu, Yang Yu, Ningbo Yu, Jianda Han, Jialing Wu
    Frontiers in Neurology.2022;[Epub]     CrossRef
  • Perioperative Brain Function Monitoring with Electroencephalography in Horses Anesthetized with Multimodal Balanced Anesthetic Protocol Subjected to Surgeries
    Carla Murillo, Hsin-Yi Weng, Ann B. Weil, Matthias Kreuzer, Jeff C. Ko
    Animals.2022; 12(20): 2851.     CrossRef
  • Prediction of the gait function using the nigrostriatal and corticoreticulospinal tracts of the affected hemisphere in a cerebral infarct: A diffusion tensor imaging study
    Sung Ho Jang, Sang Seok Yeo, Min Jye Cho
    Medicine.2022; 101(39): e30788.     CrossRef
  • The Romberg's sign: from walking in the dark to tests on the force plate
    Anastasia I. Mezenchuk, Oleg V. Kubryak
    Almanac of Clinical Medicine.2022; 50(5): 335.     CrossRef
  • Role of Cervical Spinal Magnetic Stimulation in Improving Posture and Functional Ambulation of Patients with Relapsing Remitting Multiple Sclerosis
    Shereen I. Fawaz, Shin-Ichi Izumi, Soha M. Hamada, Abir A. Omara, Ghada O. Wassef, Heba Gamal Saber, Sherihan M. Salama, Cristina Fonte
    Rehabilitation Research and Practice.2022; 2022: 1.     CrossRef
  • The brain-body disconnect: A somatic sensory basis for trauma-related disorders
    Breanne E. Kearney, Ruth A. Lanius
    Frontiers in Neuroscience.2022;[Epub]     CrossRef
  • Neurophysiological mechanisms of gait disturbance in advanced Parkinson's disease patients
    Kaoru Takakusaki, Mirai Takahashi, Tomohiro Noguchi, Ryosuke Chiba
    Neurology and Clinical Neuroscience.2022;[Epub]     CrossRef
  • Dual-task walking improvement with enhanced kinesthetic awareness in Parkinson’s disease with mild gait impairment: EEG connectivity and clinical implication
    Cheng-Ya Huang, Yu-An Chen, Ruey-Meei Wu, Ing-Shiou Hwang
    Frontiers in Aging Neuroscience.2022;[Epub]     CrossRef
  • Trends in vestibular pathology: persistent postural perceptual dizziness (PPPD)
    Daniela Cîrpaciu, Vlad Andrei Budu, Cristina-Maria Goanţă
    ORL.ro.2022; 4(57): 14.     CrossRef
  • Biomechanical and Sensory Feedback Regularize the Behavior of Different Locomotor Central Pattern Generators
    Kaiyu Deng, Alexander J. Hunt, Nicholas S. Szczecinski, Matthew C. Tresch, Hillel J. Chiel, C. J. Heckman, Roger D. Quinn
    Biomimetics.2022; 7(4): 226.     CrossRef
  • Phase-dependent modulation of the vestibular–cerebellar network via combined alternating current stimulation influences human locomotion and posture
    Hisato Nakazono, Takanori Taniguchi, Tsubasa Mitsutake, Akinori Takeda, Emi Yamada, Katsuya Ogata
    Frontiers in Neuroscience.2022;[Epub]     CrossRef
  • Gait Recovery Characteristic According to the Injury Aspect of Descending Motor Pathway in a Chronic Stroke Patient: a Case Study
    Sang Seok Yeo
    The Journal of Korean Physical Therapy.2022; 34(6): 326.     CrossRef
  • Cortico-Subthalamic Field Potentials Support Classification of the Natural Gait Cycle in Parkinson’s Disease and Reveal Individualized Spectral Signatures
    Kenneth H. Louie, Ro’ee Gilron, Maria S. Yaroshinsky, Melanie A. Morrison, Julia Choi, Coralie de Hemptinne, Simon Little, Philip A. Starr, Doris D. Wang
    eneuro.2022; 9(6): ENEURO.0325-22.2022.     CrossRef
  • Test-retest reliability and minimal detectable change of the computerized dynamic posturography PROPRIO for adults with chronic traumatic brain injury
    Guilherme M. Cesar, Thad W. Buster, Judith M. Burnfield
    Disability and Rehabilitation.2021; 43(14): 2038.     CrossRef
  • Joint-Position Sense Accuracy Is Equally Affected by Vision among Children with and without Cerebral Palsy
    Flávia de Andrade e Souza Mazuchi, Luis Mochizuki, Joseph Hamill, Patricia Martins Franciulli, Aline Bigongiari, Isabella Tábata de Almeida Martins, Ulysses Fernandes Ervilha
    Journal of Motor Behavior.2021; 53(2): 209.     CrossRef
  • Cortical responses to whole‐body balance perturbations index perturbation magnitude and predict reactive stepping behavior
    Teodoro Solis‐Escalante, Mitchel Stokkermans, Michael X. Cohen, Vivian Weerdesteyn
    European Journal of Neuroscience.2021; 54(12): 8120.     CrossRef
  • White Matter Microstructure of the Cerebellar Peduncles Is Associated with Balance Performance during Sensory Re-Weighting in People with Multiple Sclerosis
    Arianna D. Odom, Sutton B. Richmond, Brett W. Fling
    The Cerebellum.2021; 20(1): 92.     CrossRef
  • Highly challenging balance and gait training for individuals with Parkinson’s disease improves pace, rhythm and variability domains of gait – A secondary analysis from a randomized controlled trial
    Linda Rennie, Arve Opheim, Espen Dietrichs, Niklas Löfgren, Erika Franzén
    Clinical Rehabilitation.2021; 35(2): 200.     CrossRef
  • Traumatic brain injury-induced cerebral microbleeds in the elderly
    Luca Toth, Andras Czigler, Peter Horvath, Balint Kornyei, Nikolett Szarka, Attila Schwarcz, Zoltan Ungvari, Andras Buki, Peter Toth
    GeroScience.2021; 43(1): 125.     CrossRef
  • Altered prefrontal cortex responses in older adults with subjective memory complaints and dementia during dual‐task gait: An fNIRS study
    Wei‐Peng Teo, Timo Rantalainen, Nathan Nuzum, Leah Valente, Helen Macpherson
    European Journal of Neuroscience.2021; 53(4): 1324.     CrossRef
  • Connectivity of the Cingulate Sulcus Visual Area (CSv) in Macaque Monkeys
    V De Castro, A T Smith, A L Beer, C Leguen, N Vayssière, Y Héjja-Brichard, P Audurier, B R Cottereau, J B Durand
    Cerebral Cortex.2021; 31(2): 1347.     CrossRef
  • Efficient Actor-Critic Reinforcement Learning With Embodiment of Muscle Tone for Posture Stabilization of the Human Arm
    Masami Iwamoto, Daichi Kato
    Neural Computation.2021; 33(1): 129.     CrossRef
  • Single-Session Cerebellar Transcranial Direct Current Stimulation Affects Postural Control Learning and Cerebellar Brain Inhibition in Healthy Individuals
    Natsuki Katagiri, Saki Kawakami, Sayuri Okuyama, Tadaki Koseki, Daisuke Kudo, Shigehiro Namba, Shigeo Tanabe, Tomofumi Yamaguchi
    The Cerebellum.2021; 20(2): 203.     CrossRef
  • Is freezing of gait correlated with postural control in patients with moderate‐to‐severe Parkinson’s disease?
    Daniel Boari Coelho, Caroline Ribeiro de Souza, Andrea Cristina de Lima‐Pardini, Renata de Castro Treza, Thiago Kenzo Fujioka Shida, Carla Silva‐Batista, Luis Augusto Teixeira, Yoland Smith
    European Journal of Neuroscience.2021; 53(4): 1189.     CrossRef
  • The use of Motor and Cognitive Dual-Task quantitative assessment on subjects with mild cognitive impairment: A systematic review
    Gianmaria Mancioppi, Laura Fiorini, Erika Rovini, Filippo Cavallo
    Mechanisms of Ageing and Development.2021; 193: 111393.     CrossRef
  • Functional Near-infrared Spectroscopy Reveals the Compensatory Potential of Pre-frontal Cortical Activity for Standing Balance in Young and Older Adults
    Rebecca J. St George, Mark R. Hinder, Rohan Puri, Eliza Walker, Michele L. Callisaya
    Neuroscience.2021; 452: 208.     CrossRef
  • Effects of Cognitive Over Postural Demands on Upright Standing Among Young Adults
    Kell Grandjean da Costa, Erika K. Hussey, Eduardo Bodnariuc Fontes, Alekya Menta, John W. Ramsay, Clifford L. Hancock, Kari L. Loverro, Elizabeth Marfeo, Nathan Ward
    Perceptual and Motor Skills.2021; 128(1): 80.     CrossRef
  • Asymmetry and Variability Should Be Included in the Assessment of Gait Function in Poststroke Hemiplegia With Independent Ambulation During Early Rehabilitation
    Woo-Sub Kim, Hanboram Choi, Jung-Woo Jung, Joon Sik Yoon, Ju Hyong Jeoung
    Archives of Physical Medicine and Rehabilitation.2021; 102(4): 611.     CrossRef
  • Electroencephalographic Study on Sensory Integration in Visually Induced Postural Sway
    Takahiro Kagawa, Scott Makeig, Makoto Miyakoshi
    Journal of Cognitive Neuroscience.2021; 33(3): 482.     CrossRef
  • Benefits of nonlinear analysis indices of walking stride interval in the evaluation of neurodegenerative diseases
    Frédéric Dierick, Charlotte Vandevoorde, Frédéric Chantraine, Olivier White, Fabien Buisseret
    Human Movement Science.2021; 75: 102741.     CrossRef
  • Freezing of Gait in Parkinson’s Disease: Invasive and Noninvasive Neuromodulation
    Shervin Rahimpour, Wendy Gaztanaga, Amol P. Yadav, Stephano J. Chang, Max O. Krucoff, Iahn Cajigas, Dennis A. Turner, Doris D. Wang
    Neuromodulation: Technology at the Neural Interface.2021; 24(5): 829.     CrossRef
  • Response Inhibition Deficits in Women with the FMR1 Premutation are Associated with Age and Fall Risk
    Carly Moser, Lyndsay Schmitt, Joseph Schmidt, Amanda Fairchild, Jessica Klusek
    Brain and Cognition.2021; 148: 105675.     CrossRef
  • The potential of noisy galvanic vestibular stimulation for optimizing and assisting human performance
    Kim Lajoie, Daniel S. Marigold, Bulmaro A. Valdés, Carlo Menon
    Neuropsychologia.2021; 152: 107751.     CrossRef
  • Evaluation of vestibular functions and balance in Edirne Band musicians
    Halit Selçuk, Sevgi Özdinç, Menekşe Karahan, Ayşe Zeynep Yılmazer Kayatekin, Enis Uluçam
    Work.2021; 68(2): 415.     CrossRef
  • A review of movement disorders in chemotherapy-induced neurotoxicity
    Allison B. Wang, Stephen N. Housley, Ann Marie Flores, Sheetal M. Kircher, Eric J. Perreault, Timothy C. Cope
    Journal of NeuroEngineering and Rehabilitation.2021;[Epub]     CrossRef
  • REM Sleep Without Atonia and Gait Impairment in People with Mild-to-Moderate Parkinson’s Disease
    Sommer L. Amundsen-Huffmaster, Matthew N. Petrucci, Maria E. Linn-Evans, Jae Woo Chung, Michael J. Howell, Aleksandar Videnovic, Paul J. Tuite, Scott E. Cooper, Colum D. MacKinnon
    Journal of Parkinson's Disease.2021; 11(2): 767.     CrossRef
  • Age-Related Changes in Presynaptic Inhibition During Gait Initiation
    Solival Santos Filho, Daniel Boari Coelho, Carlos Ugrinowitsch, Caroline Ribeiro de Souza, Fernando Henrique Magalhães, Andrea Cristina de Lima-Pardini, Éden Marcos Braga de Oliveira, Eugenia Mattos, Luis Augusto Teixeira, Carla Silva-Batista, David Le Co
    The Journals of Gerontology: Series A.2021; 76(4): 568.     CrossRef
  • A synthetic kinematic index of trunk displacement conveying the overall motor condition in Parkinson’s disease
    Emahnuel Troisi Lopez, Roberta Minino, Pierpaolo Sorrentino, Rosaria Rucco, Anna Carotenuto, Valeria Agosti, Domenico Tafuri, Valentino Manzo, Marianna Liparoti, Giuseppe Sorrentino
    Scientific Reports.2021;[Epub]     CrossRef
  • Gait in Benign Paroxysmal Positional Vertigo
    Yong-Hyun Lim, Kyunghun Kang, Ho-Won Lee, Ji-Soo Kim, Sung-Hee Kim
    Frontiers in Neurology.2021;[Epub]     CrossRef
  • Pigeon as a model to study peripheral projections from the horizontal semicircular canal vestibular apparatus to a brainstem target immunoreactive for AMPA
    João Roberto Rocha, Maria de Fátima Passetto, Julianne dos Santos Maldonado-Menetti, Ana Lúcia Beirão Cabral, Claudio Antônio Barbosa de Toledo, Marcia Koike
    Acta Cirúrgica Brasileira.2021;[Epub]     CrossRef
  • Center of pressure responses to unpredictable external perturbations indicate low accuracy in predicting fall risk in people with Parkinson’s disease
    Gabriel Antonio Gazziero Moraca, Victor Spiandor Beretta, Paulo Cezar Rocha Santos, Priscila Nóbrega‐Sousa, Diego Orcioli‐Silva, Rodrigo Vitório, Lilian Teresa Bucken Gobbi
    European Journal of Neuroscience.2021; 53(8): 2901.     CrossRef
  • Gait analysis in a rat model of traumatic brain injury
    John Reed, Antigone Grillakis, Alyssa Kline, Anwar E. Ahmed, Kimberly R. Byrnes
    Behavioural Brain Research.2021; 405: 113210.     CrossRef
  • Vitamin D, Falls and Balance Capacity Impacts in Older Adults: Update
    Ray Marks
    Journal of Aging Research and Healthcare.2021; 3(4): 22.     CrossRef
  • Coordinated features in jaw and neck muscle activities induced by chewing of soft and hard gum in healthy subjects
    Tomohiro Ishii, Noriyuki Narita, Hiroshi Endo, Masanobu Wakami, Masakazu Okubo, Takeshi Uchida, Ikuo Kantake, Koh Shibutani
    Clinical and Experimental Dental Research.2021; 7(5): 868.     CrossRef
  • Cortical activity and gait parameter characteristics in people with multiple sclerosis during unobstructed gait and obstacle avoidance
    Felipe Balistieri Santinelli, Emerson Sebastião, Marina Hiromi Kuroda, Vinicius Christianini Moreno, Julia Pilon, Luiz Henrique Palucci Vieira, Fabio Augusto Barbieri
    Gait & Posture.2021; 86: 226.     CrossRef
  • Distinct cortical thickness patterns link disparate cerebral cortex regions to select mobility domains
    Inbal Maidan, Anat Mirelman, Jeffrey M. Hausdorff, Yaakov Stern, Christian G. Habeck
    Scientific Reports.2021;[Epub]     CrossRef
  • Brain connectivity during simulated balance in older adults with and without Parkinson's disease
    Elizabeth P. Pasman, Martin J. McKeown, Saurabh Garg, Taylor W. Cleworth, Bastiaan R. Bloem, J. Timothy Inglis, Mark G. Carpenter
    NeuroImage: Clinical.2021; 30: 102676.     CrossRef
  • Innovative motor and cognitive dual-task approaches combining upper and lower limbs may improve dementia early detection
    Gianmaria Mancioppi, Laura Fiorini, Erika Rovini, Radia Zeghari, Auriane Gros, Valeria Manera, Philippe Robert, Filippo Cavallo
    Scientific Reports.2021;[Epub]     CrossRef
  • Cognition mediates the relation between structural network efficiency and gait in small vessel disease
    Mengfei Cai, Mina A. Jacob, David G. Norris, Marco Duering, Frank-Erik de Leeuw, Anil M. Tuladhar
    NeuroImage: Clinical.2021; 30: 102667.     CrossRef
  • Does the impaired postural control in Parkinson's disease affect the habituation to non-sequential external perturbation trials?
    Victor Spiandor Beretta, Mark Gregory Carpenter, Fabio Augusto Barbieri, Paulo Cezar Rocha Santos, Diego Orcioli-Silva, Marcelo Pinto Pereira, Lilian Teresa Bucken Gobbi
    Clinical Biomechanics.2021; 85: 105363.     CrossRef
  • A Neural Model of Intrinsic and Extrinsic Hippocampal Theta Rhythms: Anatomy, Neurophysiology, and Function
    Stephen Grossberg
    Frontiers in Systems Neuroscience.2021;[Epub]     CrossRef
  • A randomized sham-controlled trial on the effect of continuous positive airway pressure treatment on gait control in severe obstructive sleep apnea patients
    Sébastien Baillieul, Bernard Wuyam, Dominic Pérennou, Renaud Tamisier, Sébastien Bailly, Meriem Benmerad, Céline Piscicelli, Thibault Le Roux-Mallouf, Samuel Vergès, Jean-Louis Pépin
    Scientific Reports.2021;[Epub]     CrossRef
  • Detecting Depression Through Gait Data: Examining the Contribution of Gait Features in Recognizing Depression
    Yameng Wang, Jingying Wang, Xiaoqian Liu, Tingshao Zhu
    Frontiers in Psychiatry.2021;[Epub]     CrossRef
  • Effects of prolonged-release fampridine on multiple sclerosis-related gait impairments. A crossover, double-blinded, placebo-controlled study
    Maxime Valet, Souraya El Sankari, Vincent Van Pesch, Christine Detrembleur, Thierry Lejeune, Gaëtan Stoquart
    Clinical Biomechanics.2021; 86: 105382.     CrossRef
  • Gait Impairment and Upper Extremity Disturbance Are Associated With Total Magnetic Resonance Imaging Cerebral Small Vessel Disease Burden
    Yutong Hou, Yue Li, Shuna Yang, Wei Qin, Lei Yang, Wenli Hu
    Frontiers in Aging Neuroscience.2021;[Epub]     CrossRef
  • Long-Lasting Event-Related Beta Synchronizations of Electroencephalographic Activity in Response to Support-Surface Perturbations During Upright Stance: A Pilot Study Associating Beta Rebound and Active Monitoring in the Intermittent Postural Control
    Akihiro Nakamura, Yasuyuki Suzuki, Matija Milosevic, Taishin Nomura
    Frontiers in Systems Neuroscience.2021;[Epub]     CrossRef
  • Dual-task walking and automaticity after Stroke: Insights from a secondary analysis and imaging sub-study of a randomised controlled trial
    Johnny Collett, Melanie K Fleming, Daan Meester, Emad Al-Yahya, Derick T Wade, Andrea Dennis, Piergiorgio Salvan, Andrew Meaney, Janet Cockburn, Joanna Dawes, Heidi Johansen-Berg, Helen Dawes
    Clinical Rehabilitation.2021; 35(11): 1599.     CrossRef
  • Aerobic Exercise Combined With Transcranial Direct Current Stimulation Over the Prefrontal Cortex in Parkinson Disease: Effects on Cortical Activity, Gait, and Cognition
    Núbia Ribeiro Conceição, Lilian Teresa Bucken Gobbi, Priscila Nóbrega-Sousa, Diego Orcioli-Silva, Victor Spiandor Beretta, Ellen Lirani-Silva, Alexandre Hideki Okano, Rodrigo Vitório
    Neurorehabilitation and Neural Repair.2021; 35(8): 717.     CrossRef
  • Non-ambulatory measures of lower extremity sensorimotor function are associated with walking function in Multiple Sclerosis
    Sumire Sato, John Buonaccorsi, Jules D. Miehm, Jongil Lim, Caitlin Rajala, Farnaz Khalighinejad, Carolina Ionete, Jane A. Kent, Richard E.A. van Emmerik
    Multiple Sclerosis and Related Disorders.2021; 53: 103051.     CrossRef
  • Self-Perception of the Knee Is Associated with Joint Motion during the Loading Response in Individuals with Knee Osteoarthritis: A Pilot Cross-Sectional Study
    Haruki Toda, Tsubasa Maruyama, Koji Fujita, Yuki Yamauchi, Mitsunori Tada
    Sensors.2021; 21(12): 4009.     CrossRef
  • Fields of Forel Brain Stimulation Improves Levodopa-Unresponsive Gait and Balance Disorders in Parkinson's Disease
    Maria Sheila Guimarães Rocha, Julian Leticia de Freitas, Carlos Daniel Miranda Costa, Maira Okada de Oliveira, Paulo Roberto Terzian, João Welberthon Matos Queiroz, Jamana Barbosa Ferraz, João Fellipe Santos Tatsch, Diogo Coutinho Soriano, Clement Hamani,
    Neurosurgery.2021; 89(3): 450.     CrossRef
  • The effects of transcranial direct current stimulation on gait in patients with Parkinson’s disease: a systematic review
    Fateme Pol, Mohammad Ali Salehinejad, Hamzeh Baharlouei, Michael A. Nitsche
    Translational Neurodegeneration.2021;[Epub]     CrossRef
  • Cerebral Hemodynamic Responses to the Difficulty Level of Ambulatory Tasks in Patients With Parkinson’s Disease: A Systematic Review and Meta-Analysis
    Jin P. Lin, Hong S. Feng, Hua Zhai, Xia Shen
    Neurorehabilitation and Neural Repair.2021; 35(9): 755.     CrossRef
  • The Dendrite Arbor of Purkinje Cells Is Altered Following to Tail Regeneration in the Leopard Gecko
    Stefanie S Bradley, Erika Howe, Craig D C Bailey, Matthew K Vickaryous
    Integrative and Comparative Biology.2021; 61(2): 370.     CrossRef
  • The diagnosis of central vestibular disorder based on the complementary examination of the vestibulospinal reflex
    Stefani Maihoub, András Molnár, László Tamás, Ágnes Szirmai
    Journal of Otology.2021;[Epub]     CrossRef
  • Compromised Brain Activity With Age During a Game-Like Dynamic Balance Task: Single- vs. Dual-Task Performance
    Veerle de Rond, Diego Orcioli-Silva, Bauke Wybren Dijkstra, Jean-Jacques Orban de Xivry, Annette Pantall, Alice Nieuwboer
    Frontiers in Aging Neuroscience.2021;[Epub]     CrossRef
  • Cognitive and Motor Cortical Activity During Cognitively Demanding Stepping Tasks in Older People at Low and High Risk of Falling
    Paulo H. S. Pelicioni, Stephen R. Lord, Daina L. Sturnieks, Bethany Halmy, Jasmine C. Menant
    Frontiers in Medicine.2021;[Epub]     CrossRef
  • Uniqueness of gait kinematics in a cohort study
    Gunwoo Park, Kyoung Min Lee, Seungbum Koo
    Scientific Reports.2021;[Epub]     CrossRef
  • Visual Effect on Brain Connectome That Scales Feedforward and Feedback Processes of Aged Postural System During Unstable Stance
    Yi-Ching Chen, Chien-Chun Huang, Chen-Guang Zhao, Ing-Shiou Hwang
    Frontiers in Aging Neuroscience.2021;[Epub]     CrossRef
  • The Biology and Pathobiology of Glutamatergic, Cholinergic, and Dopaminergic Signaling in the Aging Brain
    Anna Gasiorowska, Malgorzata Wydrych, Patrycja Drapich, Maciej Zadrozny, Marta Steczkowska, Wiktor Niewiadomski, Grazyna Niewiadomska
    Frontiers in Aging Neuroscience.2021;[Epub]     CrossRef
  • Dual-Task Training Effect on Cognitive and Body Function, β-amyloid Levels in Alzheimer’s Dementia Patients: A Randomized Controlled Trial
    Seung-Min Nam, Seong-gil Kim
    The Journal of Korean Physical Therapy.2021; 33(3): 136.     CrossRef
  • Graph‐theoretical analysis of EEG functional connectivity during balance perturbation in traumatic brain injury: A pilot study
    Vikram Shenoy Handiru, Alaleh Alivar, Armand Hoxha, Soha Saleh, Easter S. Suviseshamuthu, Guang H. Yue, Didier Allexandre
    Human Brain Mapping.2021; 42(14): 4427.     CrossRef
  • Adapting Footfall Rhythmicity to Auditory Perturbations Affects Resilience of Locomotor Behavior: A Proof-of-Concept Study
    Deepak K. Ravi, Caroline C. Heimhofer, William R. Taylor, Navrag B. Singh
    Frontiers in Neuroscience.2021;[Epub]     CrossRef
  • Towards real-world generalizability of a circuit for action-stopping
    Ricci Hannah, Adam R. Aron
    Nature Reviews Neuroscience.2021; 22(9): 538.     CrossRef
  • Physiological and cognitive determinants of gait in middle-aged, older-aged and oldest-aged Asian adults – The Yishun study
    Lay Khoon Lau, Shiou Liang Wee, Jagadish Ullal Mallya, Philip Lin Kiat Yap, Wei Jun Benedict Pang, Kexun Kenneth Chen, Khalid Abdul Jabbar, Wei Ting Seah, Tze Pin Ng
    Aging and Health Research.2021; 1(3): 100030.     CrossRef
  • Amble Gait EEG Points at Complementary Cortical Networks Underlying Stereotypic Multi-Limb Co-ordination
    Joyce B. Weersink, Natasha M. Maurits, Bauke M. de Jong
    Frontiers in Human Neuroscience.2021;[Epub]     CrossRef
  • Age-Related Differences in Corticospinal Excitability and Anticipatory Postural Adjustments of the Trunk
    Rebecca S. Rowland, Ned Jenkinson, Shin-Yi Chiou
    Frontiers in Aging Neuroscience.2021;[Epub]     CrossRef
  • Postural sway in the moving room scenario: New evidence for functional dissociation between self-motion perception and postural control
    Kentaro Horiuchi, Kuniyasu Imanaka, Masami Ishihara, Manabu Sakakibara
    PLOS ONE.2021; 16(9): e0257212.     CrossRef
  • Altered Cortical Cholinergic Network in Parkinson’s Disease at Different Stage: A Resting-State fMRI Study
    Wenshuang Sheng, Tao Guo, Cheng Zhou, Jingjing Wu, Ting Gao, Jiali Pu, Baorong Zhang, Minming Zhang, Yunjun Yang, Xiaojun Guan, Xiaojun Xu
    Frontiers in Aging Neuroscience.2021;[Epub]     CrossRef
  • Gait phenotype in batten disease: A marker of disease progression
    John R. Ostergaard
    European Journal of Paediatric Neurology.2021;[Epub]     CrossRef
  • High Sensory Responsiveness in Older Adults is Associated with Walking Outside but Not Inside: Proof of Concept Study
    Maayan Agmon, Tami Bar-Shalita, Rachel Kizony
    Clinical Interventions in Aging.2021; Volume 16: 1651.     CrossRef
  • Association of Posture Instability with Dopamine Drop of Nigrostriatal System and Hypometabolism of Cerebral Cortex in Parkinson’s Disease
    Hongyan Wang, Hong-Yu Li, Xiuhai Guo, Yongtao Zhou
    Current Neurovascular Research.2021; 18(2): 244.     CrossRef
  • Does Subthalamic Deep Brain Stimulation Impact Asymmetry and Dyscoordination of Gait in Parkinson’s Disease?
    Deepak K. Ravi, Christian R. Baumann, Elena Bernasconi, Michelle Gwerder, Niklas K. Ignasiak, Mechtild Uhl, Lennart Stieglitz, William R. Taylor, Navrag B. Singh
    Neurorehabilitation and Neural Repair.2021; 35(11): 1020.     CrossRef
  • Any Behavioral Change May Have Physiological Significance: Benign Neglect In Tier I Neurotoxicity Testing
    David V. Gauvin, Zachary J. Zimmermann
    Current Opinion in Toxicology.2021;[Epub]     CrossRef
  • Impact of regional white matter hyperintensities on specific gait function in Alzheimer's disease and mild cognitive impairment
    Noriko Ogama, Hidetoshi Endo, Shosuke Satake, Shumpei Niida, Hidenori Arai, Takashi Sakurai
    Journal of Cachexia, Sarcopenia and Muscle.2021; 12(6): 2045.     CrossRef
  • The effects of different frequencies of rhythmic acoustic stimulation on gait stability in healthy elderly individuals: a pilot study
    Roberta Minino, Emahnuel Troisi Lopez, Pierpaolo Sorrentino, Rosaria Rucco, Anna Lardone, Matteo Pesoli, Domenico Tafuri, Laura Mandolesi, Giuseppe Sorrentino, Marianna Liparoti
    Scientific Reports.2021;[Epub]     CrossRef
  • Feasibility and tolerance of a robotic postural training to improve standing in a person with ambulatory spinal cord injury
    V. Santamaria, T. D. Luna, S. K. Agrawal
    Spinal Cord Series and Cases.2021;[Epub]     CrossRef
  • A Novel Viewpoint on the Anticipatory Postural Adjustments During Gait Initiation
    Veronica Farinelli, Francesco Bolzoni, Silvia Maria Marchese, Roberto Esposti, Paolo Cavallari
    Frontiers in Human Neuroscience.2021;[Epub]     CrossRef
  • Tai Chi and Yoga for Improving Balance on One Leg: A Neuroimaging and Biomechanics Study
    Xin-Peng Chen, Le-Jun Wang, Xiao-Qian Chang, Kuan Wang, Hui-Fang Wang, Ming Ni, Wen-Xin Niu, Ming Zhang
    Frontiers in Neurology.2021;[Epub]     CrossRef
  • Sleep deprivation affects gait control
    Guilherme S. Umemura, João Pedro Pinho, Jacques Duysens, Hermano Igo Krebs, Arturo Forner-Cordero
    Scientific Reports.2021;[Epub]     CrossRef
  • Postural Control Strategies and Balance-Related Factors in Individuals with Traumatic Transtibial Amputations
    Barbora Kolářová, Miroslav Janura, Zdeněk Svoboda, Petr Kolář, Dagmar Tečová, Milan Elfmark
    Sensors.2021; 21(21): 7284.     CrossRef
  • Walking While Talking and Prefrontal Oxygenation in Motoric Cognitive Risk Syndrome: Clinical and Pathophysiological Aspects
    Cristina Udina, Emmeline Ayers, Marco Inzitari, Joe Verghese, Marco Canevelli
    Journal of Alzheimer's Disease.2021; 84(4): 1585.     CrossRef
  • Cortical and Cerebellar Oscillatory Responses to Postural Instability in Parkinson's Disease
    Taylor J. Bosch, Stefan Kammermeier, Christopher Groth, Matt Leedom, Elizabeth K. Hanson, Patti Berg-Poppe, Arun Singh
    Frontiers in Neurology.2021;[Epub]     CrossRef
  • Circuits for State-Dependent Modulation of Locomotion
    Alejandro J. Pernía-Andrade, Nikolaus Wenger, Maria S. Esposito, Philip Tovote
    Frontiers in Human Neuroscience.2021;[Epub]     CrossRef
  • Postural and gait symptoms in de novo Parkinson's disease patients correlate with cholinergic white matter pathology
    Muhammad Nazmuddin, Jan-Willem van Dalen, Ronald J.H. Borra, Gilles N. Stormezand, Harm Jan van der Horn, Sygrid van der Zee, Jeffrey Boertien, Teus van Laar
    Parkinsonism & Related Disorders.2021; 93: 43.     CrossRef
  • Neurophysiological Support of Motor Control in “Hybrid” Postures. Literature Review
    N. D. Babanov, E. A. Biryukova
    Neuroscience and Behavioral Physiology.2021; 51(8): 1162.     CrossRef
  • A Narrative Review of Alternate Gait Training Using Knee-ankle-foot Orthosis in Stroke Patients with Severe Hemiparesis
    Hiroaki ABE, Kei KADOWAKI, Naohide TSUJIMOTO, Toru OKANUKA
    Physical Therapy Research.2021; 24(3): 195.     CrossRef
  • Intrinsic brainstem circuits comprised of Chx10-expressing neurons contribute to reticulospinal output in mice
    Jeremy W. Chopek, Ying Zhang, Robert M. Brownstone
    Journal of Neurophysiology.2021; 126(6): 1978.     CrossRef
  • Spinal Cord Circuits: Models and Reality
    Uwe Windhorst
    Neurophysiology.2021; 53(3-6): 142.     CrossRef
  • Cerebellar transcranial direct current stimulation modulates the effect of cerebellar transcranial magnetic stimulation on the excitability of spinal reflex
    Akiyoshi Matsugi, Yohei Okada
    Neuroscience Research.2020; 150: 37.     CrossRef
  • Dynamic running hexapod robot based on high-performance computing
    Xiaokun Leng, Songhao Piao, Lin Chang, Zhicheng He, Zheng Zhu
    The Journal of Supercomputing.2020; 76(2): 844.     CrossRef
  • Optic flow and attention alter locomotion differently in the young and old
    Kenneth S. Pechtl, J. Richard Jennings, Mark S. Redfern
    Gait & Posture.2020; 76: 1.     CrossRef
  • Axonal regeneration and functional recovery driven by endogenous Nogo receptor antagonist LOTUS in a rat model of unilateral pyramidotomy
    Ryu Ueno, Hajime Takase, Jun Suenaga, Masao Kishimoto, Yuji Kurihara, Kohtaro Takei, Nobutaka Kawahara, Tetsuya Yamamoto
    Experimental Neurology.2020; 323: 113068.     CrossRef
  • Local dynamic stability during long-fatiguing walks in people with multiple sclerosis
    I. Arpan, P.C. Fino, B.W. Fling, F. Horak
    Gait & Posture.2020; 76: 122.     CrossRef
  • Instrumental assessment of balance and gait in depression: A systematic review
    Martino Belvederi Murri, Federico Triolo, Alice Coni, Carlo Tacconi, Erika Nerozzi, Andrea Escelsior, Matteo Respino, Francesca Neviani, Marco Bertolotti, Klea Bertakis, Lorenzo Chiari, Stamatula Zanetidou, Mario Amore
    Psychiatry Research.2020; 284: 112687.     CrossRef
  • Baropodometric evaluation of foot load distribution during gait in the group of professionally active nurses
    Anna Kołcz, Natalia Główka, Mateusz Kowal, Małgorzata Paprocka‐Borowicz
    Journal of Occupational Health.2020;[Epub]     CrossRef
  • Effect of aging on H-reflex response to fatigue
    Andrew Philip Lavender, Sadik Balkozak, Mustafa Görkem Özyurt, Betilay Topkara, İlhan Karacan, İdil Bilici, Anne-Marie Hill, Kemal Sitki Türker
    Experimental Brain Research.2020; 238(2): 273.     CrossRef
  • The repeatability of the instrumented timed Up & Go test: The performance of older adults and parkinson’s disease patients under different conditions
    Slavka Viteckova, Radim Krupicka, Petr Dusek, Vaclav Cejka, Patrik Kutilek, Jan Novak, Zoltan Szabo, Evžen Růžička
    Biocybernetics and Biomedical Engineering.2020; 40(1): 363.     CrossRef
  • Cerebral Cortical Activity Following Non-invasive Cerebellar Stimulation—a Systematic Review of Combined TMS and EEG Studies
    Lara Fernandez, Nigel C. Rogasch, Michael Do, Gillian Clark, Brendan P. Major, Wei-Peng Teo, Linda K. Byrne, Peter G. Enticott
    The Cerebellum.2020; 19(2): 309.     CrossRef
  • Resting-state fMRI reveals increased functional connectivity in the cerebellum but decreased functional connectivity of the caudate nucleus in Parkinson’s disease
    Oliver Kaut, Clemens Mielacher, René Hurlemann, Ullrich Wüllner
    Neurological Research.2020; 42(1): 62.     CrossRef
  • Gait Generation and Its Energy Efficiency Based on Rat Neuromusculoskeletal Model
    Misaki Toeda, Shinya Aoi, Soichiro Fujiki, Tetsuro Funato, Kazuo Tsuchiya, Dai Yanagihara
    Frontiers in Neuroscience.2020;[Epub]     CrossRef
  • Cognitive and physical markers of prodromal dementia: A 12‐year‐long population study
    Giulia Grande, Debora Rizzuto, Davide L. Vetrano, Anna Marseglia, Nicola Vanacore, Erika J. Laukka, Anna‐Karin Welmer, Laura Fratiglioni
    Alzheimer's & Dementia.2020; 16(1): 153.     CrossRef
  • The sensory role of the sole of the foot: Review and update on clinical perspectives
    Frederic J.F. Viseux
    Neurophysiologie Clinique.2020; 50(1): 55.     CrossRef
  • Overactivity in Chronic Pain, the Role of Pain-related Endurance and Neuromuscular Activity
    Monika I. Hasenbring, Nicole E. Andrews, Gerold Ebenbichler
    The Clinical Journal of Pain.2020; 36(3): 162.     CrossRef
  • Motor tract integrity predicts walking recovery
    Julie Soulard, Coline Huber, Sebastien Baillieul, Antoine Thuriot, Felix Renard, Bérengère Aubert Broche, Alexandre Krainik, Nicolas Vuillerme, Assia Jaillard
    Neurology.2020; 94(6): e583.     CrossRef
  • Altered intra- and inter-network functional connectivity in patients with persistent postural-perceptual dizziness
    Kangzhi Li, Lihong Si, Bin Cui, Xia Ling, Bo Shen, Xu Yang
    NeuroImage: Clinical.2020; 26: 102216.     CrossRef
  • The role of physical exercise and rehabilitation in delirium
    N. Gual, M. García-Salmones, L. Brítez, N. Crespo, C. Udina, L. M. Pérez, M. Inzitari
    European Geriatric Medicine.2020; 11(1): 83.     CrossRef
  • Neural circuits of idiopathic Normal Pressure Hydrocephalus: A perspective review of brain connectivity and symptoms meta-analysis
    Alessandra Griffa, Dimitri Van De Ville, François R. Herrmann, Gilles Allali
    Neuroscience & Biobehavioral Reviews.2020; 112: 452.     CrossRef
  • Orbitrap mass spectrometry for monitoring the ganglioside pattern in human cerebellum development and aging
    Raluca Ica, Alina Petrut, Cristian V.A. Munteanu, Mirela Sarbu, Željka Vukelić, Ligia Petrica, Alina D. Zamfir
    Journal of Mass Spectrometry.2020; 55(5): e4502.     CrossRef
  • What are the association patterns between handgrip strength and adverse health conditions? A topical review
    Ryan McGrath, Nathaniel Johnson, Lukus Klawitter, Sean Mahoney, Kara Trautman, Caroline Carlson, Ella Rockstad, Kyle J Hackney
    SAGE Open Medicine.2020; 8: 205031212091035.     CrossRef
  • Cortical Oscillations during Gait: Wouldn’t Walking Be So Automatic?
    Arnaud Delval, Madli Bayot, Luc Defebvre, Kathy Dujardin
    Brain Sciences.2020; 10(2): 90.     CrossRef
  • Loss of presynaptic inhibition for step initiation in parkinsonian individuals with freezing of gait
    Jumes Leopoldino Oliveira Lira, Carlos Ugrinowitsch, Daniel Boari Coelho, Luis Augusto Teixeira, Andrea Cristina Lima‐Pardini, Fernando Henrique Magalhães, Egberto Reis Barbosa, Fay B. Horak, Carla Silva‐Batista
    The Journal of Physiology.2020; 598(8): 1611.     CrossRef
  • Which Effects on Neuroanatomy and Path-Integration Survive? Results of a Randomized Controlled Study on Intensive Balance Training
    Milos Dordevic, Marco Taubert, Patrick Müller, Martin Riemer, Jörn Kaufmann, Anita Hökelmann, Notger G. Müller
    Brain Sciences.2020; 10(4): 210.     CrossRef
  • Freezing of gait in Parkinson’s disease: pathophysiology, risk factors and treatments
    Chao Gao, Jun Liu, Yuyan Tan, Shengdi Chen
    Translational Neurodegeneration.2020;[Epub]     CrossRef
  • Clinical experience of comprehensive treatment on the balance function of Parkinsonʼs disease
    Haitao Li, Siquan Liang, Yang Yu, Yue Wang, Yuanyuan Cheng, Hechao Yang, Xiaoguang Tong
    Medicine.2020; 99(19): e20154.     CrossRef
  • Digital natives and dual task: Handling it but not immune against cognitive-locomotor interferences
    Frédéric Dierick, Fabien Buisseret, Mathieu Renson, Adèle Mae Luta, Slavko Rogan
    PLOS ONE.2020; 15(5): e0232328.     CrossRef
  • Functional neuroimaging of human postural control: A systematic review with meta-analysis
    Bauke W. Dijkstra, Esther M.J. Bekkers, Moran Gilat, Veerle de Rond, Robert M. Hardwick, Alice Nieuwboer
    Neuroscience & Biobehavioral Reviews.2020; 115: 351.     CrossRef
  • The neural correlates of falls: Alterations in large-scale resting-state networks in elderly fallers
    Inbal Maidan, Amgad Droby, Yael Jacob, Nir Giladi, Jeffrey M Hausdorff, Anat Mirelman
    Gait & Posture.2020; 80: 56.     CrossRef
  • Short rehabilitation training program may improve postural control in children with autism spectrum disorders: preliminary evidences
    Simona Caldani, Paola Atzori, Hugo Peyre, Richard Delorme, Maria Pia Bucci
    Scientific Reports.2020;[Epub]     CrossRef
  • Effects of injuries to descending motor pathways on restoration of gait in patients with pontine hemorrhage
    Sang Seok Yeo, Sung Ho Jang, Ga Young Park, Seunghue Oh
    Journal of Stroke and Cerebrovascular Diseases.2020; 29(7): 104857.     CrossRef
  • Handgrip strength accuracy as discriminator of functional independence in centenarian women
    Artur Rodrigues Fortunato, Raquel Ester Lima da Silva, Giovana Zarpellon Mazo
    Revista Brasileira de Cineantropometria & Desempenho Humano.2020;[Epub]     CrossRef
  • Assessing the effect of current steering on the total electrical energy delivered and ambulation in Parkinson’s disease
    Daphne Hui, Aditya A. Murgai, Greydon Gilmore, Shabna I. Mohideen, Andrew G. Parrent, Mandar S. Jog
    Scientific Reports.2020;[Epub]     CrossRef
  • Speech disorders and anxiety: interaction mechanisms and therapy potential
    E.E. Vasenina, O.S. Levin
    Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova.2020; 120(4): 136.     CrossRef
  • Progression of motor disability in cerebral palsy: The role of concomitant epilepsy
    Tomoyuki Takano, Anri Hayashi, Yuki Harada
    Seizure.2020; 80: 81.     CrossRef
  • Turning Characteristics of the More-Affected Side in Parkinson’s Disease Patients with Freezing of Gait
    Hwayoung Park, Changhong Youm, Myeounggon Lee, Byungjoo Noh, Sang-Myung Cheon
    Sensors.2020; 20(11): 3098.     CrossRef
  • Fifteen Years of Wireless Sensors for Balance Assessment in Neurological Disorders
    Alessandro Zampogna, Ilaria Mileti, Eduardo Palermo, Claudia Celletti, Marco Paoloni, Alessandro Manoni, Ivan Mazzetta, Gloria Dalla Costa, Carlos Pérez-López, Filippo Camerota, Letizia Leocani, Joan Cabestany, Fernanda Irrera, Antonio Suppa
    Sensors.2020; 20(11): 3247.     CrossRef
  • Muscle Synergies in Parkinson’s Disease
    Ilaria Mileti, Alessandro Zampogna, Alessandro Santuz, Francesco Asci, Zaccaria Del Prete, Adamantios Arampatzis, Eduardo Palermo, Antonio Suppa
    Sensors.2020; 20(11): 3209.     CrossRef
  • Transcranial direct current stimulation combined with physical or cognitive training in people with Parkinson’s disease: a systematic review
    Victor Spiandor Beretta, Núbia Ribeiro Conceição, Priscila Nóbrega-Sousa, Diego Orcioli-Silva, Luana Karla Braz Fonseca Dantas, Lilian Teresa Bucken Gobbi, Rodrigo Vitório
    Journal of NeuroEngineering and Rehabilitation.2020;[Epub]     CrossRef
  • Assessing the Temporal Organization of Walking Variability: A Systematic Review and Consensus Guidelines on Detrended Fluctuation Analysis
    Deepak K. Ravi, Vivien Marmelat, William R. Taylor, Karl M. Newell, Nick Stergiou, Navrag B. Singh
    Frontiers in Physiology.2020;[Epub]     CrossRef
  • Backward locomotor treadmill training combined with transcutaneous spinal direct current stimulation in stroke: a randomized pilot feasibility and safety study
    Oluwole O Awosika, Saira Matthews, Emily J Staggs, Pierce Boyne, Xiao Song, Bridget A Rizik, Heidi J Sucharew, Christina Zhang, Gabrielle Mungcal, Rohitha Moudgal, Amit Bhattacharya, Kari Dunning, Daniel Woo, Brett M Kissela
    Brain Communications.2020;[Epub]     CrossRef
  • Behavioural manifestations and associated non-motor features of freezing of gait: A narrative review and theoretical framework
    Kaylena A. Ehgoetz Martens, Daniel S. Peterson, Quincy J. Almeida, Simon J.G. Lewis, Jeffrey M. Hausdorff, Alice Nieuwboer
    Neuroscience & Biobehavioral Reviews.2020; 116: 350.     CrossRef
  • New insight into Parkinson’s disease‐related impairment of the automatic control of upright stance
    Cédrick T. Bonnet, Arnaud Delval, Tarkeshwar Singh, Yann‐Romain Kechabia, Luc Defebvre
    European Journal of Neuroscience.2020; 52(12): 4851.     CrossRef
  • Firing activity of locus coeruleus noradrenergic neurons decreases in necdin-deficient mice, an animal model of Prader–Willi syndrome
    Rui-Ni Wu, Wei-Chen Hung, Ching-Tsuey Chen, Li-Ping Tsai, Wen-Sung Lai, Ming-Yuan Min, Shi-Bing Wong
    Journal of Neurodevelopmental Disorders.2020;[Epub]     CrossRef
  • A functional observational battery for evaluation of neurological outcomes in a rat model of acute bacterial meningitis
    Jane Fisher, Chiara Pavan, Luisa S. Ohlmeier, Bo Nilson, Iben Lundgaard, Adam Linder, Peter Bentzer
    Intensive Care Medicine Experimental.2020;[Epub]     CrossRef
  • Impact of Extremity Manipulation on Postural Sway Characteristics: A Preliminary, Randomized Crossover Study
    Christopher A. Malaya, Joshua Haworth, Katherine A. Pohlman, Cody Powell, Dean L. Smith
    Journal of Manipulative and Physiological Therapeutics.2020; 43(5): 457.     CrossRef
  • Dissociated motor learning and de-adaptation in patients with functional gait disorders
    Denise Lin, Patricia Castro, Amy Edwards, Akila Sekar, Mark J Edwards, Jan Coebergh, Adolfo M Bronstein, Diego Kaski
    Brain.2020; 143(8): 2594.     CrossRef
  • Multicenter Validation of Metabolic Abnormalities Related to PSP According to the MDS‐PSP Criteria
    Gloria Martí‐Andrés, Liza Bommel, Sanne K. Meles, Mario Riverol, Rafael Valentí, Rosalie V. Kogan, Remco J. Renken, Vita Gurvits, Teus Laar, Marco Pagani, Elena Prieto, M. Rosario Luquin, Klaus L. Leenders, Javier Arbizu
    Movement Disorders.2020; 35(11): 2009.     CrossRef
  • Gait initiation in progressive supranuclear palsy: brain metabolic correlates
    Chiara Palmisano, Massimiliano Todisco, Giorgio Marotta, Jens Volkmann, Claudio Pacchetti, Carlo A. Frigo, Gianni Pezzoli, Ioannis U. Isaias
    NeuroImage: Clinical.2020; 28: 102408.     CrossRef
  • Altered Brain Function in Cerebral Small Vessel Disease Patients With Gait Disorders: A Resting-State Functional MRI Study
    Xia Zhou, Chao Zhang, Linlin Li, Yimei Zhang, Wei Zhang, Wenwen Yin, Xianfeng Yu, Xiaoqun Zhu, Yinfeng Qian, Zhongwu Sun
    Frontiers in Aging Neuroscience.2020;[Epub]     CrossRef
  • Lower Thalamic Blood Flow Is Associated With Slower Stride Velocity in Older Adults
    Noah D. Koblinsky, Sarah Atwi, Ellen Cohen, Nicole D. Anderson, Carol E. Greenwood, Bradley J. MacIntosh, Andrew D. Robertson
    Frontiers in Aging Neuroscience.2020;[Epub]     CrossRef
  • Gait-related frequency modulation of beta oscillatory activity in the subthalamic nucleus of parkinsonian patients
    Andrea Canessa, Chiara Palmisano, Ioannis U. Isaias, Alberto Mazzoni
    Brain Stimulation.2020;[Epub]     CrossRef
  • Immersive Virtual Reality to Restore Natural Long-Range Autocorrelations in Parkinson’s Disease Patients’ Gait During Treadmill Walking
    Alexis Lheureux, Julien Lebleu, Caroline Frisque, Corentin Sion, Gaëtan Stoquart, Thibault Warlop, Christine Detrembleur, Thierry Lejeune
    Frontiers in Physiology.2020;[Epub]     CrossRef
  • Non-pharmacological Treatment Challenges in Early Parkinson's Disease for Axial and Cognitive Symptoms: A Mini Review
    Gabriella Sharpe, Antonella Macerollo, Margherita Fabbri, Elina Tripoliti
    Frontiers in Neurology.2020;[Epub]     CrossRef
  • Genetic basis of falling risk susceptibility in the UK Biobank Study
    Katerina Trajanoska, Lotta J. Seppala, Carolina Medina-Gomez, Yi-Hsiang Hsu, Sirui Zhou, Natasja M. van Schoor, Lisette C. P. G. M. de Groot, David Karasik, J. Brent Richards, Douglas P. Kiel, Andre G. Uitterlinden, John R. B. Perry, Nathalie van der Veld
    Communications Biology.2020;[Epub]     CrossRef
  • Effect of Different Intensities of Transcranial Direct Current Stimulation on Postural Response to External Perturbation in Patients With Parkinson’s Disease
    Victor Spiandor Beretta, Rodrigo Vitório, Priscila Nóbrega-Sousa, Núbia Ribeiro Conceição, Diego Orcioli-Silva, Marcelo Pinto Pereira, Lilian Teresa Bucken Gobbi
    Neurorehabilitation and Neural Repair.2020; 34(11): 1009.     CrossRef
  • Adapting to the Mechanical Properties and Active Force of an Exoskeleton by Altering Muscle Synergies in Chronic Stroke Survivors
    Linda Rinaldi, Ling-Fung Yeung, Patrick Chi-Hong Lam, Marco Y. C. Pang, Raymond Kai-Yu Tong, Vincent C. K. Cheung
    IEEE Transactions on Neural Systems and Rehabilitation Engineering.2020; 28(10): 2203.     CrossRef
  • Brain networks associated with anticipatory postural adjustments in Parkinson’s disease patients with freezing of gait
    Andrea C. de Lima-Pardini, Daniel B. Coelho, Mariana P. Nucci, Catarina C. Boffino, Alana X. Batista, Raymundo M. de Azevedo Neto, Carla Silva-Batista, Egberto R. Barbosa, Rajal G. Cohen, Fay B. Horak, Luis A. Teixeira, Edson Amaro Jr
    NeuroImage: Clinical.2020; 28: 102461.     CrossRef
  • Rhythmic neural activity is comodulated with short-term gait modifications during first-time use of a dummy prosthesis: a pilot study
    Vera G. M. Kooiman, Helco G. van Keeken, Natasha M. Maurits, Vivian Weerdesteyn, Teodoro Solis-Escalante
    Journal of NeuroEngineering and Rehabilitation.2020;[Epub]     CrossRef
  • Deep brain stimulation: a review of the open neural engineering challenges
    Matteo Vissani, Ioannis U Isaias, Alberto Mazzoni
    Journal of Neural Engineering.2020; 17(5): 051002.     CrossRef
  • History of and Insights Into Spinal Cord Stimulation in Parkinson Disease
    Bruno Braz Garcia, Edson Ricardo Junior, Mariana Ferreira Pereira de Araújo, Hougelle Simplício
    Neurorehabilitation and Neural Repair.2020; 34(11): 967.     CrossRef
  • Influence of Robotic Mechanotherapy in Various Combinations with Non-Invasive Electrostimulation of Muscles and Spinal Cord on the Postural Balance in Children with Severe Forms of Cerebral Palsy
    I.E. Nikityuk, E.L. Kononova, G.A. Ikoeva, I.Yu Solokhina
    Bulletin of Restorative Medicine.2020; 98(4): 26.     CrossRef
  • Toward a Regulatory Qualification of Real-World Mobility Performance Biomarkers in Parkinson’s Patients Using Digital Mobility Outcomes
    Marco Viceconti, Sabina Hernandez Penna, Wilhelmus Dartee, Claudia Mazzà, Brian Caulfield, Clemens Becker, Walter Maetzler, Judith Garcia-Aymerich, Giorgio Davico, Lynn Rochester
    Sensors.2020; 20(20): 5920.     CrossRef
  • Brain Network Oscillations During Gait in Parkinson’s Disease
    Doris D. Wang, Julia T. Choi
    Frontiers in Human Neuroscience.2020;[Epub]     CrossRef
  • Disrupted white matter integrity and network connectivity are related to poor motor performance
    Feifei Zhai, Jie Liu, Ning Su, Fei Han, Lixin Zhou, Jun Ni, Ming Yao, Shuyang Zhang, Zhengyu Jin, Liying Cui, Feng Tian, Yicheng Zhu
    Scientific Reports.2020;[Epub]     CrossRef
  • Serotonergic Modulation of Locomotor Activity From Basal Vertebrates to Mammals
    Aurélie Flaive, Maxime Fougère, Cornelis Immanuel van der Zouwen, Dimitri Ryczko
    Frontiers in Neural Circuits.2020;[Epub]     CrossRef
  • Classification of Rhythmic Cortical Activity Elicited by Whole-Body Balance Perturbations Suggests the Cortical Representation of Direction-Specific Changes in Postural Stability
    Teodoro Solis-Escalante, Digna De Kam, Vivian Weerdesteyn
    IEEE Transactions on Neural Systems and Rehabilitation Engineering.2020; 28(11): 2566.     CrossRef
  • Executive Control of Walking in People With Parkinson’s Disease With Freezing of Gait
    Rodrigo Vitorio, Samuel Stuart, Martina Mancini
    Neurorehabilitation and Neural Repair.2020; 34(12): 1138.     CrossRef
  • Postural instability in Parkinson’s disease: Review and bottom-up rehabilitative approaches
    Frederic J.F. Viseux, Arnaud Delval, Luc Defebvre, Martin Simoneau
    Neurophysiologie Clinique.2020; 50(6): 479.     CrossRef
  • Can dual-task paradigms predict Falls better than single task? – A systematic literature review
    Madli Bayot, Kathy Dujardin, Lucile Dissaux, Céline Tard, Luc Defebvre, Cédrick T. Bonnet, Etienne Allart, Gilles Allali, Arnaud Delval
    Neurophysiologie Clinique.2020; 50(6): 401.     CrossRef
  • Neural Correlates of Freezing of Gait in Parkinson's Disease: An Electrophysiology Mini-Review
    J. Sebastian Marquez, S. M. Shafiul Hasan, Masudur R. Siddiquee, Corneliu C. Luca, Virendra R. Mishra, Zoltan Mari, Ou Bai
    Frontiers in Neurology.2020;[Epub]     CrossRef
  • Association of Postural Instability with Autonomic Dysfunction in Early Parkinson’s Disease
    Sooyeoun You, Hyun Ah Kim, Hyung Lee
    Journal of Clinical Medicine.2020; 9(11): 3786.     CrossRef
  • Neural Mechanisms for Locomotor and Postural Control in Man and Its Application to Neurorehabilitation
    Ichiro Miyai
    The Japanese Journal of Rehabilitation Medicine.2020; 57(10): 965.     CrossRef
  • A case of generalized tonic seizures related to acute myocarditis
    Jeong-Hwan Yang, Jae Yoon Na, Jinseok Lee, Da-Eun Kim, Jinyoung Song, I-Seok Kang, Hyeryun Yeh
    Pediatric Emergency Medicine Journal.2020; 7(2): 127.     CrossRef
  • Rapid and robust patterns of spontaneous locomotor deficits in mouse models of Huntington’s disease
    Taneli Heikkinen, Timo Bragge, Niina Bhattarai, Teija Parkkari, Jukka Puoliväli, Outi Kontkanen, Patrick Sweeney, Larry C. Park, Ignacio Munoz-Sanjuan, Yuqing Li
    PLOS ONE.2020; 15(12): e0243052.     CrossRef
  • The Relationship of Rapid Eye Movement Sleep Behavior Disorder and Freezing of Gait in Parkinson’s Disease
    Chelsea Mae N Nobleza, Mariah Siddiqui, Parth V Shah, Prachi Balani, Angel R Lopez, Safeera Khan
    Cureus.2020;[Epub]     CrossRef
  • Influence of Autocorrelated Rhythmic Auditory Stimulations on Parkinson’s Disease Gait Variability: Comparison With Other Auditory Rhythm Variabilities and Perspectives
    Alexis Lheureux, Thibault Warlop, Charline Cambier, Baptiste Chemin, Gaëtan Stoquart, Christine Detrembleur, Thierry Lejeune
    Frontiers in Physiology.2020;[Epub]     CrossRef
  • A Roadmap to Inform Development, Validation and Approval of Digital Mobility Outcomes: The Mobilise-D Approach
    Lynn Rochester, Claudia Mazzà, Arne Mueller, Brian Caulfield, Marie McCarthy, Clemens Becker, Ram Miller, Paolo Piraino, Marco Viceconti, Wilhelmus P. Dartee, Judith Garcia-Aymerich, Aida A. Aydemir, Beatrix Vereijken, Valdo Arnera, Nadir Ammour, Michael
    Digital Biomarkers.2020; 4(Suppl. 1): 13.     CrossRef
  • Cerebellar contribution to locomotor behavior: A neurodevelopmental perspective
    Aaron Sathyanesan, Vittorio Gallo
    Neurobiology of Learning and Memory.2019; 165: 106861.     CrossRef
  • A meta-analysis: Parkinson's disease and dual-task walking
    Tiphanie E. Raffegeau, Lisa M. Krehbiel, Nyeonju Kang, Frency J. Thijs, Lori J.P. Altmann, James H. Cauraugh, Chris J. Hass
    Parkinsonism & Related Disorders.2019; 62: 28.     CrossRef
  • Treadmill exercise intervention improves gait and postural control in alpha-synuclein mouse models without inducing cerebral autophagy
    Georgia Minakaki, Fabio Canneva, Frédéric Chevessier, Frederik Bode, Stefanie Menges, Ivanna K. Timotius, Liubov S. Kalinichenko, Holger Meixner, Christian P. Müller, Bjoern M. Eskofier, Nicolas Casadei, Olaf Riess, Rolf Schröder, Jürgen Winkler, Wei Xian
    Behavioural Brain Research.2019; 363: 199.     CrossRef
  • Acupuncture Enhances Communication between Cortices with Damaged White Matters in Poststroke Motor Impairment
    Xiao Han, Lijun Bai, Chuanzhu Sun, Xuan Niu, Yanzhe Ning, Zhen Chen, Yingying Li, Kuangshi Li, Diyang Lyu, Caihong Fu, Fangyuan Cui, Zhengguang Chen, Zhongjian Tan, Lixin Tang, Yihuai Zou
    Evidence-Based Complementary and Alternative Medicine.2019; 2019: 1.     CrossRef
  • Improvement of gait and balance by non-invasive brain stimulation: its use in rehabilitation
    Soumya Ghosh
    Expert Review of Neurotherapeutics.2019; 19(2): 133.     CrossRef
  • Neural Substrates of Cognitive Motor Interference During Walking; Peripheral and Central Mechanisms
    Emad Al-Yahya, Wala’ Mahmoud, Daan Meester, Patrick Esser, Helen Dawes
    Frontiers in Human Neuroscience.2019;[Epub]     CrossRef
  • Efficiency of Sensorimotor Networks: Posture and Gait in Young and Older Adults
    G. Di Scala, M. Dupuy, E. Guillaud, E. Doat, E. Barse, B. Dillhareguy, F.A.M. Jean, M. Audiffren, J.R. Cazalets, S. Chanraud
    Experimental Aging Research.2019; 45(1): 41.     CrossRef
  • Central pattern generators in the brainstem and spinal cord: an overview of basic principles, similarities and differences
    Inge Steuer, Pierre A. Guertin
    Reviews in the Neurosciences.2019; 30(2): 107.     CrossRef
  • The Effects of Dual‐Task Cognitive Interference and Environmental Challenges on Balance in Huntington's Disease
    Nicollette L. Purcell, Jennifer G. Goldman, Bichun Ouyang, Bryan Bernard, Joan A. O'Keefe
    Movement Disorders Clinical Practice.2019; 6(3): 202.     CrossRef
  • Descending dopaminergic control of brainstem locomotor circuits
    Maxime Fougère, Aurélie Flaive, Alain Frigon, Dimitri Ryczko
    Current Opinion in Physiology.2019; 8: 30.     CrossRef
  • Visual Fixation and Continuous Head Rotations Have Minimal Effect on Set-Point Adaptation to Magnetic Vestibular Stimulation
    Bryan K. Ward, David S. Zee, Dale C. Roberts, Michael C. Schubert, Nicolas Pérez-Fernández, Jorge Otero-Millan
    Frontiers in Neurology.2019;[Epub]     CrossRef
  • Computational modeling of brainstem circuits controlling locomotor frequency and gait
    Jessica Ausborn, Natalia A Shevtsova, Vittorio Caggiano, Simon M Danner, Ilya A Rybak
    eLife.2019;[Epub]     CrossRef
  • Structure and function of the mesencephalic locomotor region in normal and parkinsonian primates
    Brian Lau, Chantal François, Carine Karachi
    Current Opinion in Physiology.2019; 8: 121.     CrossRef
  • Ambulation Patterns Post-Discharge in Older Adults Identified as Fall Risk: A Descriptive Pilot Study
    Barbara J. King, Roger Brown, Linsey Steege, Haocen Wang, Fang-lin Kuo, Cynthia Brown
    Research in Gerontological Nursing.2019; 12(3): 113.     CrossRef
  • Quantification of trunk segmental coordination and head stability in laterally unstable sitting identifies aging and cerebellar ataxia
    Koshiro Haruyama, Kenji Kasai, Ryohei Makino, Fumihiko Hoshi, Ken Nishihara
    Clinical Biomechanics.2019; 63: 127.     CrossRef
  • Deterioration of Brain Neural Tracts in Elderly Women with Sarcopenia
    So Young Kwak, Sang Gyu Kwak, Tae Sang Yoon, Eun Jung Kong, Min Cheol Chang
    The American Journal of Geriatric Psychiatry.2019; 27(8): 774.     CrossRef
  • “Special K” Drug on Adolescent Rats: Oxidative Damage and Neurobehavioral Impairments
    Sabrina de Carvalho Cartágenes, Luanna Melo Pereira Fernandes, Taiana Cristina Vilhena Sarmento Carvalheiro, Thais Miranda de Sousa, Antônio Rafael Quadros Gomes, Marta Chagas Monteiro, Ricardo Sousa de Oliveira Paraense, Maria Elena Crespo-López, Rafael
    Oxidative Medicine and Cellular Longevity.2019; 2019: 1.     CrossRef
  • Current models of speech motor control: A control-theoretic overview of architectures and properties
    Benjamin Parrell, Adam C. Lammert, Gregory Ciccarelli, Thomas F. Quatieri
    The Journal of the Acoustical Society of America.2019; 145(3): 1456.     CrossRef
  • Falls and Fractures in Diabetes—More than Bone Fragility
    Nicklas Højgaard Rasmussen, Jakob Dal
    Current Osteoporosis Reports.2019; 17(3): 147.     CrossRef
  • Expression of aggressiveness modulates mesencephalic c-fos activation during a social interaction test in Japanese quail (Coturnix japonica)
    Jorge Martin Caliva, Fernando Falkenburger Melleu, Jose Marino-Neto, Raul Hector Marin, Jackelyn Melissa Kembro
    Behavioural Brain Research.2019; 367: 221.     CrossRef
  • Positive verbal suggestion optimizes postural control
    Bernardo Villa-Sánchez, Mehran Emadi Andani, Giulia Menegaldo, Michele Tinazzi, Mirta Fiorio
    Scientific Reports.2019;[Epub]     CrossRef
  • Neuromodulation to improve gait and balance function using a sensory neuroprosthesis in people who report insensate feet – A randomized control cross-over study
    Sara R. Koehler-McNicholas, Lori Danzl, Alana Y. Cataldo, Lars I. E. Oddsson, Alfonso Fasano
    PLOS ONE.2019; 14(4): e0216212.     CrossRef
  • Selective suppression of the vestibulo-ocular reflex during human locomotion
    Haike Dietrich, Max Wuehr
    Journal of Neurology.2019; 266(S1): 101.     CrossRef
  • Gait stride-to-stride variability and foot clearance pattern analysis in Idiopathic Parkinson’s Disease and Vascular Parkinsonism
    Flora Ferreira, Miguel F. Gago, Estela Bicho, Catarina Carvalho, Nafiseh Mollaei, Lurdes Rodrigues, Nuno Sousa, Pedro Pereira Rodrigues, Carlos Ferreira, João Gama
    Journal of Biomechanics.2019; 92: 98.     CrossRef
  • Von der Biomechanik zur Bioinformatik
    Philip Eckardt
    Osteopathische Medizin.2019; 20(2): 27.     CrossRef
  • Measuring gait speed to better identify prodromal dementia
    Giulia Grande, Federico Triolo, Arturo Nuara, Anna-Karin Welmer, Laura Fratiglioni, Davide L. Vetrano
    Experimental Gerontology.2019; 124: 110625.     CrossRef
  • Effects of transcranial direct current stimulation (tDCS) on balance improvement: a systematic review and meta-analysis
    Maria Clara D. Soares de Moura, Fuad A. Hazime, Luana V. Marotti Aparicio, Luanda A. C. Grecco, André R. Brunoni, Renata Hydeé Hasue
    Somatosensory & Motor Research.2019; 36(2): 122.     CrossRef
  • Long-Term Effects of Whole-Body Vibration on Human Gait: A Systematic Review and Meta-Analysis
    Matthieu Fischer, Thomas Vialleron, Guillaume Laffaye, Paul Fourcade, Tarek Hussein, Laurence Chèze, Paul-André Deleu, Jean-Louis Honeine, Eric Yiou, Arnaud Delafontaine
    Frontiers in Neurology.2019;[Epub]     CrossRef
  • Effective Parameters for Gait Analysis in Experimental Models for Evaluating Peripheral Nerve Injuries in Rats
    Ivair Matias Júnior, Priscila Medeiros, Renato Leonardo de Freita, Hilton Vicente-César, José Raniery Ferreira Junior, Hélio Rubens Machado, Rafael Menezes-Reis
    Neurospine.2019; 16(2): 305.     CrossRef
  • Freezing of gait in Parkinson’s disease reflects a sudden derangement of locomotor network dynamics
    Nicoló G Pozzi, Andrea Canessa, Chiara Palmisano, Joachim Brumberg, Frank Steigerwald, Martin M Reich, Brigida Minafra, Claudio Pacchetti, Gianni Pezzoli, Jens Volkmann, Ioannis U Isaias
    Brain.2019; 142(7): 2037.     CrossRef
  • Usual walking and obstacle avoidance are influenced by depressive and anxiety symptoms in patients with Parkinson's disease
    Priscila Nóbrega‐Sousa, Diego Orcioli‐Silva, Ellen Lirani‐Silva, Victor Spiandor Beretta, Rodrigo Vitório, Lilian Teresa Bucken Gobbi
    Geriatrics & Gerontology International.2019; 19(9): 868.     CrossRef
  • Complexity based measures of postural stability provide novel evidence of functional decline in fragile X premutation carriers
    Clodagh O’Keeffe, Laura P. Taboada, Niamh Feerick, Louise Gallagher, Timothy Lynch, Richard B. Reilly
    Journal of NeuroEngineering and Rehabilitation.2019;[Epub]     CrossRef
  • Motor-Cognitive Neural Network Communication Underlies Walking Speed in Community-Dwelling Older Adults
    Victoria N. Poole, On-Yee Lo, Thomas Wooten, Ikechukwu Iloputaife, Lewis A. Lipsitz, Michael Esterman
    Frontiers in Aging Neuroscience.2019;[Epub]     CrossRef
  • Programmable coupled oscillators for synchronized locomotion
    Sourav Dutta, Abhinav Parihar, Abhishek Khanna, Jorge Gomez, Wriddhi Chakraborty, Matthew Jerry, Benjamin Grisafe, Arijit Raychowdhury, Suman Datta
    Nature Communications.2019;[Epub]     CrossRef
  • Immediate effects of rhythmic auditory stimulation on gait kinematics in Parkinson’s disease ON/OFF medication
    Carmen Erra, Ilaria Mileti, Marco Germanotta, Martina Petracca, Isabella Imbimbo, Alessandro De Biase, Stefano Rossi, Diego Ricciardi, Alessandra Pacilli, Enrica Di Sipio, Eduardo Palermo, Anna Rita Bentivoglio, Luca Padua
    Clinical Neurophysiology.2019; 130(10): 1789.     CrossRef
  • Patterns of co‐altered brain structure and function underlying neurological soft signs in schizophrenia spectrum disorders
    Dusan Hirjak, Mahmoud Rashidi, Stefan Fritze, Alina L. Bertolino, Lena S. Geiger, Zhenxiang Zang, Katharina M. Kubera, Mike M. Schmitgen, Fabio Sambataro, Vince D. Calhoun, Matthias Weisbrod, Heike Tost, Robert C. Wolf
    Human Brain Mapping.2019; 40(17): 5029.     CrossRef
  • Spinal Cord Stimulation for Freezing of Gait: From Bench to Bedside
    Erich Talamoni Fonoff, Andrea C. de Lima-Pardini, Daniel Boari Coelho, Bernardo Assumpção Monaco, Birajara Machado, Carolina Pinto de Souza, Maria Gabriela dos Santos Ghilardi, Clement Hamani
    Frontiers in Neurology.2019;[Epub]     CrossRef
  • Head Anticipation During Locomotion With Auditory Instruction in the Presence and Absence of Visual Input
    Felix Dollack, Monica Perusquía-Hernández, Hideki Kadone, Kenji Suzuki
    Frontiers in Human Neuroscience.2019;[Epub]     CrossRef
  • Neuroplasticity Modifications Following a Lower‐Limb Amputation: A Systematic Review
    Francisco Molina‐Rueda, Cristian Navarro‐Fernández, Alicia Cuesta‐Gómez, Isabel M Alguacil‐Diego, Alberto Molero‐Sánchez, María Carratalá‐Tejada
    PM&R.2019; 11(12): 1326.     CrossRef
  • Correlation between selected gait variables and emotion using virtual reality
    Young Kim, JunYoung Moon, Nak-Jun Sung, Min Hong
    Journal of Ambient Intelligence and Humanized Computing.2019;[Epub]     CrossRef
  • Neural substrates of reduced walking activity after supratentorial stroke: A voxel-based lesion symptom mapping study
    Sébastien Baillieul, Charlotte Elsworth-Edelsten, Arnaud Saj, Gilles Allali
    Human Movement Science.2019; 67: 102517.     CrossRef
  • Olfactory Stimulation with Japanese Soy Sauce Improves Upper Limb Performance
    Yutaka Yano, Yoshihiro Murata, Mutsuo Taniguchi, Fumino Okutani, Masahiro Yamaguchi, Hideto Kaba
    Occupational Therapy International.2019; 2019: 1.     CrossRef
  • Botulinum toxin A injection into the entopeduncular nucleus improves dynamic locomotory parameters in hemiparkinsonian rats
    Adrianna R. Tsang, Nagalingam Rajakumar, Mandar S. Jog, David I. Finkelstein
    PLOS ONE.2019; 14(10): e0223450.     CrossRef
  • Functional and Brain Activation Changes Following Specialized Upper-Limb Exercise in Parkinson’s Disease
    Luca Valerio Messa, Federica Ginanneschi, Davide Momi, Lucia Monti, Carla Battisti, David Cioncoloni, Barbara Pucci, Emiliano Santarnecchi, Alessandro Rossi
    Frontiers in Human Neuroscience.2019;[Epub]     CrossRef
  • Neuroimaging advances in Parkinson's disease with freezing of gait: A systematic review
    Komal Bharti, Antonio Suppa, Silvia Tommasin, Alessandro Zampogna, Sara Pietracupa, Alfredo Berardelli, Patrizia Pantano
    NeuroImage: Clinical.2019; 24: 102059.     CrossRef
  • Effects of supraspinal feedback on human gait: rhythmic auditory distortion
    Arturo Forner-Cordero, João Pedro Pinho, Guilherme Umemura, João Carlos Lourenço, Bruno Mezêncio, Cinthia Itiki, Hermano Igo Krebs
    Journal of NeuroEngineering and Rehabilitation.2019;[Epub]     CrossRef
  • Cortical disconnection of the ipsilesional primary motor cortex is associated with gait speed and upper extremity motor impairment in chronic left hemispheric stroke
    Denise M. Peters, Julius Fridriksson, Jill C. Stewart, Jessica D. Richardson, Chris Rorden, Leonardo Bonilha, Addie Middleton, Ezequiel Gleichgerrcht, Stacy L. Fritz
    Human Brain Mapping.2018; 39(1): 120.     CrossRef
  • Effects of transcranial direct current stimulation over the supplementary motor area body weight-supported treadmill gait training in hemiparetic patients after stroke
    Atsushi Manji, Kazu Amimoto, Tadamitsu Matsuda, Yoshiaki Wada, Akira Inaba, Sangkyun Ko
    Neuroscience Letters.2018; 662: 302.     CrossRef
  • Gender-related differences in neural responses to gaming cues before and after gaming: implications for gender-specific vulnerabilities to Internet gaming disorder
    Guangheng Dong, Lingxiao Wang, Xiaoxia Du, Marc N Potenza
    Social Cognitive and Affective Neuroscience.2018; 13(11): 1203.     CrossRef
  • Stem Cell Transplantation and Physical Exercise in Parkinson’s Disease, a Literature Review of Human and Animal Studies
    Jaison Daniel Cucarián Hurtado, Jenny Paola Berrío Sánchez, Ramiro Barcos Nunes, Alcyr Alves de Oliveira
    Stem Cell Reviews and Reports.2018; 14(2): 166.     CrossRef
  • Postural control and the relation with cervical sensorimotor control in patients with idiopathic adult-onset cervical dystonia
    J. De Pauw, R. Mercelis, A. Hallemans, G. Van Gils, S. Truijen, P. Cras, W. De Hertogh
    Experimental Brain Research.2018; 236(3): 803.     CrossRef
  • Efecto de un programa de rehabilitación mediante entrenamiento en tapiz rodante con tareas duales en las alteraciones del equilibrio y la marcha en el daño cerebral adquirido
    Á. Aguilera-Rubio, P. Fernández-González, F. Molina-Rueda, A. Cuesta-Gómez
    Rehabilitación.2018; 52(2): 107.     CrossRef
  • Noisy vestibular stimulation increases gait speed in normals and in bilateral vestibulopathy
    Shinichi Iwasaki, Chisato Fujimoto, Naoya Egami, Makoto Kinoshita, Fumiharu Togo, Yoshiharu Yamamoto, Tatsuya Yamasoba
    Brain Stimulation.2018; 11(4): 709.     CrossRef
  • Paradoxical kinesia induced by appetitive 50-kHz ultrasonic vocalizations in rats depends on glutamatergic mechanisms in the inferior colliculus
    Luan Castro Tonelli, Markus Wöhr, Rainer Schwarting, Liana Melo-Thomas
    Neuropharmacology.2018; 135: 172.     CrossRef
  • Managing Gait, Balance, and Posture in Parkinson’s Disease
    Bettina Debû, Clecio De Oliveira Godeiro, Jarbas Correa Lino, Elena Moro
    Current Neurology and Neuroscience Reports.2018;[Epub]     CrossRef
  • Vestibular signals in primate cortex for self-motion perception
    Yong Gu
    Current Opinion in Neurobiology.2018; 52: 10.     CrossRef
  • What If Low Back Pain Is the Most Prevalent Parkinsonism in the World?
    Jesse V. Jacobs, Sharon M. Henry, Fay B. Horak
    Frontiers in Neurology.2018;[Epub]     CrossRef
  • The Dorsal Column Lesion Model of Spinal Cord Injury and Its Use in Deciphering the Neuron‐Intrinsic Injury Response
    Callan L. Attwell, Mike van Zwieten, Joost Verhaagen, Matthew R. J. Mason
    Developmental Neurobiology.2018; 78(10): 926.     CrossRef
  • Exergames Inherently Contain Cognitive Elements as Indicated by Cortical Processing
    Phillipp Anders, Tim Lehmann, Helen Müller, Karoline B. Grønvik, Nina Skjæret-Maroni, Jochen Baumeister, Beatrix Vereijken
    Frontiers in Behavioral Neuroscience.2018;[Epub]     CrossRef
  • Phase matters: A role for the subthalamic network during gait
    Gabriele Arnulfo, Nicolò Gabriele Pozzi, Chiara Palmisano, Alice Leporini, Andrea Canessa, Joachim Brumberg, Gianni Pezzoli, Cordula Matthies, Jens Volkmann, Ioannis Ugo Isaias, Nader Pouratian
    PLOS ONE.2018; 13(6): e0198691.     CrossRef
  • Social jetlag impairs balance control
    Guilherme Silva Umemura, João Pedro Pinho, Bruno da Silva Brandão Gonçalves, Fabianne Furtado, Arturo Forner-Cordero
    Scientific Reports.2018;[Epub]     CrossRef
  • The consequence of cerebral small vessel disease: Linking brain atrophy to motor impairment in the elderly
    Ning Su, Xinyu Liang, Fei‐Fei Zhai, Li‐Xin Zhou, Jun Ni, Ming Yao, Feng Tian, Shu‐Yang Zhang, Zheng‐Yu Jin, Li‐Ying Cui, Gaolang Gong, Yi‐Cheng Zhu
    Human Brain Mapping.2018; 39(11): 4452.     CrossRef
  • Extrapyramidal deficits in ALS: a combined biomechanical and neuroimaging study
    Maryse Feron, Annabelle Couillandre, Eya Mseddi, Nicolas Termoz, Malek Abidi, Eric Bardinet, Daniel Delgadillo, Timothée Lenglet, Giorgia Querin, Marie-Laure Welter, Nadine Le Forestier, François Salachas, Gaelle Bruneteau, Maria del Mar Amador, Rabab Deb
    Journal of Neurology.2018; 265(9): 2125.     CrossRef
  • Brain responses during strategic online gaming of varying proficiencies: Implications for better gaming
    Min Wang, Guangheng Dong, Lingxiao Wang, Hui Zheng, Marc N. Potenza
    Brain and Behavior.2018; 8(8): e01076.     CrossRef
  • Adaptations to Postural Perturbations in Patients With Freezing of Gait
    Esther M. J. Bekkers, Sam Van Rossom, Elke Heremans, Kim Dockx, Surendar Devan, Sabine M. P. Verschueren, Alice Nieuwboer
    Frontiers in Neurology.2018;[Epub]     CrossRef
  • Influence of the intensity of galvanic vestibular stimulation and cutaneous stimulation on the soleus H-reflex in healthy individuals
    Yohei Okada, Tomoyuki Shiozaki, Junji Nakamura, Yuji Azumi, Miyo Inazato, Moe Ono, Honoka Kondo, Miyuki Sugitani, Akiyoshi Matsugi
    NeuroReport.2018; 29(13): 1135.     CrossRef
  • Role of medical ozone in attenuating age-related changes in the rat cerebellum
    Wael B Elkholy, Marwa A Al-Gholam
    Microscopy.2018; 67(4): 214.     CrossRef
  • A bio-inspired self-responding emotional behavior system for virtual creatures
    Diana G. Gómez-Martínez, Jonathan-Hernando Rosales, Vianney Muñoz-Jiménez, Félix Ramos, Marco Ramos
    Biologically Inspired Cognitive Architectures.2018; 26: 26.     CrossRef
  • Balancing between the two: Are freezing of gait and postural instability in Parkinson’s disease connected?
    E.M.J. Bekkers, B.W. Dijkstra, E. Heremans, S.M.P. Verschueren, B.R. Bloem, A. Nieuwboer
    Neuroscience & Biobehavioral Reviews.2018; 94: 113.     CrossRef
  • Effects of spinal cord stimulation on postural control in Parkinson's disease patients with freezing of gait
    Andrea Cristina de Lima-Pardini, Daniel Boari Coelho, Carolina Pinto Souza, Carolina Oliveira Souza, Maria Gabriela dos Santos Ghilardi, Tiago Garcia, Mariana Voos, Matija Milosevic, Clement Hamani, Luis Augusto Teixeira, Erich Talamoni Fonoff
    eLife.2018;[Epub]     CrossRef
  • The Balance of Sleep: Role of the Vestibular Sensory System
    Stephane Besnard, Brahim Tighilet, Christian Chabbert, Martin Hitier, Joseph Toulouse, Anne Legall, Marie-Laure Machado, Paul F. Smith
    Sleep Medicine Reviews.2018;[Epub]     CrossRef
  • Neural Mechanism of Human Gait and Postural Control
    Hiroaki Fujimoto, Ichiro Miyai
    The Japanese Journal of Rehabilitation Medicine.2018; 55(9): 724.     CrossRef
  • Targeting the pedunculopontine nucleus in Parkinson's disease: Time to go back to the drawing board
    Roger L. Albin, D. James Surmeier, Cecilia Tubert, Martin Sarter, Martijn L.T.M. Müller, Nicolaas I. Bohnen, William T. Dauer
    Movement Disorders.2018; 33(12): 1871.     CrossRef
  • Vestibular System and Self-Motion
    Zhixian Cheng, Yong Gu
    Frontiers in Cellular Neuroscience.2018;[Epub]     CrossRef
  • Physical exercise enhances adult cortical plasticity in a neonatal rat model of hypoxic-ischemic injury: Evidence from BOLD-fMRI and electrophysiological recordings
    Sun Young Chae, Jun Ho Jang, Geun Ho Im, Ji-Hyun Jeong, Won-Beom Jung, Sukjin Ko, Hyesoo Jie, Ji Hye Kim, Yun Sil Chang, Seungsoo Chung, Ki-Soo Kim, Jung Hee Lee
    NeuroImage.2018;[Epub]     CrossRef
  • Detection and Diagnosis of Paralysis Agitans
    Xiao Fan, Wanrong Sun, Aifeng Ren, Dou Fan, Nan Zhao, Daniyal Haider, Xiaodong Yang, Qammer H. Abbasi
    IEEE Access.2018; 6: 73023.     CrossRef
  • Effect of Treadmill Training With Eyes Open and Closed on Knee Proprioception, Functional Balance and Mobility in Children With Spastic Diplegia
    Samah Attia El Shemy
    Annals of Rehabilitation Medicine.2018; 42(6): 854.     CrossRef
  • Magnetic Vestibular Stimulation (MVS) As a Technique for Understanding the Normal and Diseased Labyrinth
    Bryan K. Ward, Jorge Otero-Millan, Prem Jareonsettasin, Michael C. Schubert, Dale C. Roberts, David S. Zee
    Frontiers in Neurology.2017;[Epub]     CrossRef
  • Postural Control in Bilateral Vestibular Failure: Its Relation to Visual, Proprioceptive, Vestibular, and Cognitive Input
    Andreas Sprenger, Jann F. Wojak, Nico M. Jandl, Christoph Helmchen
    Frontiers in Neurology.2017;[Epub]     CrossRef
  • Diabetic Neuropathy and Gait: A Review
    Uazman Alam, David R. Riley, Ravinder S. Jugdey, Shazli Azmi, Satyan Rajbhandari, Kristiaan D’Août, Rayaz A. Malik
    Diabetes Therapy.2017; 8(6): 1253.     CrossRef
  • Freezing of gait is associated with cortical thinning in mesial frontal cortex
    Miroslav Vastik, Pavel Hok, Jan Valosek, Petr Hlustik, Katerina Mensikova, Petr Kanovsky
    Biomedical Papers.2017; 161(4): 389.     CrossRef
  • Cerebral Small Vessel Disease Burden Is Associated with Motor Performance of Lower and Upper Extremities in Community-Dwelling Populations
    Ning Su, Fei-Fei Zhai, Li-Xin Zhou, Jun Ni, Ming Yao, Ming-Li Li, Zheng-Yu Jin, Gao-Lang Gong, Shu-Yang Zhang, Li-Ying Cui, Feng Tian, Yi-Cheng Zhu
    Frontiers in Aging Neuroscience.2017;[Epub]     CrossRef
  • Cough-Anal Reflex May Be the Expression of a Pre-Programmed Postural Action
    Paolo Cavallari, Francesco Bolzoni, Roberto Esposti, Carlo Bruttini
    Frontiers in Human Neuroscience.2017;[Epub]     CrossRef
  • The effect of visual information on gait parameters with induced ankle muscle fatigue
    Hye Rim Suh, Jin-Hee Hwang, Su-Young Lee
    Physical Therapy Rehabilitation Science.2017; 6(3): 140.     CrossRef
  • Construct Validity and Reliability of the SARA Gait and Posture Sub-scale in Early Onset Ataxia
    Tjitske F. Lawerman, Rick Brandsma, Renate J. Verbeek, Johannes H. van der Hoeven, Roelineke J. Lunsing, Hubertus P. H. Kremer, Deborah A. Sival
    Frontiers in Human Neuroscience.2017;[Epub]     CrossRef
  • Striatal But Not Extrastriatal Dopamine Receptors Are Critical to Dopaminergic Motor Stimulation
    Yuhan Wang, Fu-Ming Zhou
    Frontiers in Pharmacology.2017;[Epub]     CrossRef
Neurodegeneration with Brain Iron Accumulation: Diagnosis and Management
Penelope Hogarth
J Mov Disord. 2015;8(1):1-13.   Published online January 31, 2015
DOI: https://doi.org/10.14802/jmd.14034
  • 37,853 View
  • 920 Download
  • 114 Citations
AbstractAbstract PDF
Neurodegeneration with brain iron accumulation (NBIA) encompasses a group of inherited disorders that share the clinical features of an extrapyramidal movement disorder accompanied by varying degrees of intellectual disability and abnormal iron deposition in the basal ganglia. The genetic basis of ten forms of NBIA is now known. The clinical features of NBIA range from rapid global neurodevelopmental regression in infancy to mild parkinsonism with minimal cognitive impairment in adulthood, with wide variation seen between and within the specific NBIA sub-type. This review describes the clinical presentations, imaging findings, pathologic features, and treatment considerations for this heterogeneous group of disorders.

Citations

Citations to this article as recorded by  
  • Missing heritability of Wilson disease: a search for the uncharacterized mutations
    Shubhrajit Roy, Sampurna Ghosh, Jharna Ray, Kunal Ray, Mainak Sengupta
    Mammalian Genome.2023; 34(1): 1.     CrossRef
  • A Mild Form of Neurodegeneration with Brain Iron Accumulation attributed to Coenzyme A  Synthase Mutation
    Narges Hashemi, Reza Nejad Shahrokh Abadi, Afagh Alavi, Ali Reza Tavasoli, Mohammad Rohani
    Movement Disorders Clinical Practice.2023; 10(2): 331.     CrossRef
  • Neurodegeneration with brain iron accumulation: a case series highlighting phenotypic and genotypic diversity in 20 Indian families
    Haseena Sait, Somya Srivastava, Manmohan Pandey, Deepak Ravichandran, Anju Shukla, Kausik Mandal, Deepti Saxena, Arya Shambhavi, Purvi Majethia, Lakshmi Priya Rao, Suvasini Sharma, Shubha R. Phadke, Amita Moirangthem
    neurogenetics.2023; 24(2): 113.     CrossRef
  • Status Epilepticus in Coenzyme A Synthase Protein-Associated Neurodegeneration - Expanding the Clinical Phenotype
    Valaparambil Karthika Ajit, Prabhu Selvaraj, KP Divya, Bejoy Thomas, Ramshekhar N. Menon, Soumya Sundaram
    Indian Journal of Pediatrics.2023; 90(5): 519.     CrossRef
  • Exploring the genetic and genomic connection underlying neurodegeneration with brain iron accumulation and the risk for Parkinson’s disease
    Pilar Alvarez Jerez, Jose Luis Alcantud, Lucia de los Reyes-Ramírez, Anni Moore, Clara Ruz, Francisco Vives Montero, Noela Rodriguez-Losada, Prabhjyot Saini, Ziv Gan-Or, Chelsea X. Alvarado, Mary B. Makarious, Kimberley J. Billingsley, Cornelis Blauwendra
    npj Parkinson's Disease.2023;[Epub]     CrossRef
  • Substance abuse and neurodegenerative diseases: focus on ferroptosis
    Cheng Guo, Lei Chen, Yun Wang
    Archives of Toxicology.2023; 97(6): 1519.     CrossRef
  • Clinical, imaging and genetic profile of twenty-four patients with pantothenate kinase-associated neurodegeneration (PKAN)- A single centre study from India
    Neeharika Sriram, Vikram V. Holla, Riyanka Kumari, Nitish Kamble, Jitender Saini, Rohan Mahale, Manjunath Netravathi, Hansashree Padmanabha, Vykuntaraju K. Gowda, Rajani Battu, Akhilesh Pandey, Ravi Yadav, Babylakshmi Muthusamy, Pramod Kumar Pal
    Parkinsonism & Related Disorders.2023; 111: 105409.     CrossRef
  • Heme: The Lord of the Iron Ring
    Vanessa Azevedo Voltarelli, Rodrigo W. Alves de Souza, Kenji Miyauchi, Carl J. Hauser, Leo Edmond Otterbein
    Antioxidants.2023; 12(5): 1074.     CrossRef
  • Neurodegeneration with Brain Iron Accumulation and a Brief Report of the Disease in Iran
    Reza Hajati, Maziar Emamikhah, Fardad Danaee Fard, Mohammad Rohani, Afagh Alavi
    Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.2022; 49(3): 338.     CrossRef
  • A Practical Approach to Early-Onset Parkinsonism
    Giulietta M. Riboldi, Emanuele Frattini, Edoardo Monfrini, Steven J. Frucht, Alessio Di Fonzo
    Journal of Parkinson's Disease.2022; 12(1): 1.     CrossRef
  • Parkinsonism and tremor syndromes
    Steven Bellows, Joseph Jankovic
    Journal of the Neurological Sciences.2022; 433: 120018.     CrossRef
  • Aceruloplasminemia: MRI and Biochemical Profile Clue to Early Diagnosis in an Adolescent
    Swapnil Sheth, Seema Sud, Tarvinder B. S. Buxi, Salil Bhargava, Ratna Dua Puri, Sapna Sandal, C.S. Agrawal
    Journal of Pediatric Neurology.2022; 20(02): 133.     CrossRef
  • Lifetime risk of autosomal recessive neurodegeneration with brain iron accumulation (NBIA) disorders calculated from genetic databases
    Hana Kolarova, Jing Tan, Tim M. Strom, Thomas Meitinger, Matias Wagner, Thomas Klopstock
    eBioMedicine.2022; 77: 103869.     CrossRef
  • Two cases with mitochondrial membrane protein-associated neurodegeneration: genetic features and long-term clinical follow-up
    Sevcan Mercan, Sibel Aylin Ugur Iseri, Remzi Yigiter, Nihan Hande Akcakaya, Esen Saka, Zuhal Yapici
    Neurocase.2022; 28(1): 37.     CrossRef
  • CHARACTERISTIC UPPER LIMB DYSTONIA PATTERN AS A CORRELATE TO THE 'EYE OF TIGER' MRI SIGN.
    Akash Chheda, Dnyaneshwar V Jadhav, Sangeeta Ravat
    GLOBAL JOURNAL FOR RESEARCH ANALYSIS.2022; : 28.     CrossRef
  • A case of senile-onset progressive hemiballism and cognitive decline with diffuse brain iron accumulations
    I-Ting Lin, Ni-Chung Lee, Sung-Pin Fan, Chang-Jin Huang, PoWei Cheng, Jyh-Horng Chen, Chin-Hsien Lin
    Parkinsonism & Related Disorders.2022; 98: 114.     CrossRef
  • A Case of MPAN with “Eye of the Tiger Sign,” Mimicking PKAN
    Masoumeh Dehghan Manshadi, Mohammd Rohani, Ali Rezaei, Omid Aryani
    Movement Disorders Clinical Practice.2022; 9(5): 693.     CrossRef
  • Spinal cord stimulation for freezing of gait in Parkinson's disease and progressive supranuclear palsy: a case series
    Vladislav V. Kovalev, Ekaterina V. Bril, Maksim S. Semenov, Yury A. Seliverstov, Levan T. Lepsveridze
    Almanac of Clinical Medicine.2022; 50(5): 315.     CrossRef
  • Early Neuroimaging Markers in β Propeller Protein-Associated Neurodegeneration
    L. Chiapparini, G. Zorzi
    American Journal of Neuroradiology.2022; 43(12): 1815.     CrossRef
  • Deletion of ferritin H in neurons counteracts the protective effect of melatonin against traumatic brain injury‐induced ferroptosis
    Tongyu Rui, Haochen Wang, Qianqian Li, Ying Cheng, Yuan Gao, Xuexian Fang, Xuying Ma, Guang Chen, Cheng Gao, Zhiya Gu, Shunchen Song, Jian Zhang, Chunling Wang, Zufeng Wang, Tao Wang, Mingyang Zhang, Junxia Min, Xiping Chen, Luyang Tao, Fudi Wang, Chengli
    Journal of Pineal Research.2021;[Epub]     CrossRef
  • Correlation of dystonia severity and iron accumulation in Rett syndrome
    Tz-Yun Jan, Lee-Chin Wong, Ming-Tao Yang, Chien-Feng Judith Huang, Chia-Jui Hsu, Steven Shinn-Forng Peng, Wen-Yih Isaac Tseng, Wang-Tso Lee
    Scientific Reports.2021;[Epub]     CrossRef
  • The Case of a Patient with Pantothenate Kinase-Associated Neurodegeneration Presenting with a Prolonged History of Stuttering Speech and a Misdiagnosis of Parkinson’s Disease
    Prashant A Natteru, Juebin Huang
    Journal of Movement Disorders.2021; 14(1): 86.     CrossRef
  • Retrospective analysis of 17 patients with mitochondrial membrane protein-associated neurodegeneration diagnosed in Russia
    Peter Sparber, Tatiana Krylova, Svetlana Repina, Nina Demina, Galina Rudenskaya, Inna Sharkova, Artem Sharkov, Vitaly Kadyshev, Ilya Kanivets, Sergey Korostelev, Ekaterina Pomerantseva, Vladimir Kaimonov, Svetlana Mikhailova, Ekaterina Zakharova, Mikhail
    Parkinsonism & Related Disorders.2021; 84: 98.     CrossRef
  • Arching deep brain stimulation in dystonia types
    Han-Joon Kim, Beomseok Jeon
    Journal of Neural Transmission.2021; 128(4): 539.     CrossRef
  • WDR45 Gene and Its Role in Pediatric Epilepsies
    Federica Filosco, Sebastiano Billone, Ausilia Collotta, Tiziana Timpanaro, Monica Tosto, Raffaele Falsaperla, Silvia Marino, Antonio Zanghì, Andrea D. Praticò
    Journal of Pediatric Neurology.2021;[Epub]     CrossRef
  • Emerging Disease-Modifying Therapies in Neurodegeneration With Brain Iron Accumulation (NBIA) Disorders
    Vassilena Iankova, Ivan Karin, Thomas Klopstock, Susanne A. Schneider
    Frontiers in Neurology.2021;[Epub]     CrossRef
  • Neurodegeneration with brain iron accumulation: Characterization of clinical, radiological, and genetic features of pediatric patients from Southern India
    Naveen Kumar Bhardwaj, Vykuntaraju K. Gowda, Jitendra Saini, Ashwin Vivek Sardesai, Rashmi Santhoshkumar, Anita Mahadevan
    Brain and Development.2021; 43(10): 1013.     CrossRef
  • Autophagic defects observed in fibroblasts from a patient with β‐propeller protein‐associated neurodegeneration
    Jae‐Hyeok Lee, Sang Ook Nam, Eun Kyoung Kim, Jin‐Hong Shin, Seung Hwan Oh, Dongryeol Ryu, Hye Eun Lee, Ji Young Mun
    American Journal of Medical Genetics Part A.2021; 185(12): 3866.     CrossRef
  • Consensus clinical management guideline for beta‐propeller protein‐associated neurodegeneration
    Jenny L Wilson, Allison Gregory, Manju A Kurian, Ittai Bushlin, Fanny Mochel, Lisa Emrick, Laura Adang, Penelope Hogarth, Susan J Hayflick, Caleb Rogers, Jae‐Hyeok Lee, Kimberly Burke, Meg Tally Dyer, Donna Stretter
    Developmental Medicine & Child Neurology.2021; 63(12): 1402.     CrossRef
  • Findings of Magnetic Resonance and Dopamine Transporter Imaging in Beta-Propeller Protein-Associated Neurodegeneration
    Seong Ho Jeong
    Journal of the Korean Neurological Association.2021; 39(3): 239.     CrossRef
  • An Eye on Movement Disorders
    Duncan Wilson, Mark Hallett, Tim Anderson
    Movement Disorders Clinical Practice.2021; 8(8): 1168.     CrossRef
  • Towards Precision Therapies for Inherited Disorders of Neurodegeneration with Brain Iron Accumulation
    Robert V.V. Spaull, Audrey K.S. Soo, Penelope Hogarth, Susan J. Hayflick, Manju A. Kurian
    Tremor and Other Hyperkinetic Movements.2021;[Epub]     CrossRef
  • Novel C19orf12 loss-of-function variant leading to neurodegeneration with brain iron accumulation
    Antonia Lefter, Iulia Mitrea, Dan Mitrea, Vasilica Plaiasu, Aida Bertoli-Avella, Christian Beetz, Liviu Cozma, Delia Tulbă, Cristina Elena Mitu, Bogdan Ovidiu Popescu
    Neurocase.2021; 27(6): 481.     CrossRef
  • Early-onset presentation of a new subtype of β-Propeller protein-associated neurodegeneration (BPAN) caused by a de novo WDR45 deletion in a 6 year-old female patient
    Stephanie Christoforou, Kyproula Christodoulou, Violetta Anastasiadou, Paola Nicolaides
    European Journal of Medical Genetics.2020; 63(3): 103765.     CrossRef
  • A rare PANK2 deletion in the first north African patient affected with pantothenate kinase associated neurodegeneration
    Stephanie Efthymiou, Yamna Kriouile, Vincenzo Salpietro, Rhouda Hajar, Zouiri Ghizlane, Kshitij Mankad, Mohamed El Khorassani, Mhammed Aguennouz, Henry Houlden, Sarah Wiethoff
    Journal of the Neurological Sciences.2020; 410: 116639.     CrossRef
  • Chemical Chaperones as Novel Drugs for Parkinson’s Disease
    Jordi Pujols, Samuel Peña-Díaz, Irantzu Pallarès, Salvador Ventura
    Trends in Molecular Medicine.2020; 26(4): 408.     CrossRef
  • A case of novel WDR45 mutation with beta-propeller protein-associated neurodegeneration (BPAN) presenting asymmetrical extrapyramidal signs
    Ryota Sato, Michiaki Koga, Kazuhiro Iwama, Tsuyoshi Mizuguchi, Naomichi Matsumoto, Takashi Kanda
    Rinsho Shinkeigaku.2020; 60(5): 317.     CrossRef
  • Atypical pantothenate kinase-associated neurodegeneration with PANK2 mutations : clinical description and a review of the literature
    Si Pan, Chenkai Zhu
    Neurocase.2020; 26(3): 175.     CrossRef
  • The roles of iron and HFE genotype in neurological diseases
    Yunsung Kim, James R. Connor
    Molecular Aspects of Medicine.2020; 75: 100867.     CrossRef
  • L'acéruléoplasminémie héréditaire, une pathologie à ne pas méconnaître
    H. Lobbes, Q. Reynaud, S. Mainbourg, J-C. Lega, I. Durieu, S. Durupt
    La Revue de Médecine Interne.2020; 41(11): 769.     CrossRef
  • Atypical brain MRI in neurological Wilson disease
    Jong Hyeon Ahn, Joomee Song, Inyoung Choi, Ji Sun Kim, Jin Whan Cho, Jinyoung Youn
    Parkinsonism & Related Disorders.2020; 78: 70.     CrossRef
  • Clinical features and blood iron metabolism markers in children with beta-propeller protein associated neurodegeneration
    Anezka Belohlavkova, Katalin Sterbova, Cornelia Betzler, Stuve Burkhard, Axel Panzer, Markus Wolf, Petra Lassuthova, Marketa Vlckova, Martin Kyncl, Barbora Benova, Alena Jahodova, Martin Kudr, Maria Goerg, Petr Dusek, Pavel Seeman, Gerhard Kluger, Pavel K
    European Journal of Paediatric Neurology.2020;[Epub]     CrossRef
  • Loss of tyrosine hydroxylase, motor deficits and elevated iron in a mouse model of phospholipase A2G6-associated neurodegeneration (PLAN)
    Michael Minkley, Patrick MacLeod, Christopher K. Anderson, Raad Nashmi, Patrick B. Walter
    Brain Research.2020; 1748: 147066.     CrossRef
  • Nanotechnology-based Targeting of Neurodegenerative Disorders: A Promising Tool for Efficient Delivery of Neuromedicines
    Kuldeep Rajpoot
    Current Drug Targets.2020; 21(8): 819.     CrossRef
  • Brain MRI Pattern Recognition in Neurodegeneration With Brain Iron Accumulation
    Jae-Hyeok Lee, Ji Young Yun, Allison Gregory, Penelope Hogarth, Susan J. Hayflick
    Frontiers in Neurology.2020;[Epub]     CrossRef
  • Molecular Defects in Friedreich’s Ataxia: Convergence of Oxidative Stress and Cytoskeletal Abnormalities
    Frances M. Smith, Daniel J. Kosman
    Frontiers in Molecular Biosciences.2020;[Epub]     CrossRef
  • Neuroimaging of Basal Ganglia in Neurometabolic Diseases in Children
    Justyna Paprocka, Magdalena Machnikowska-Sokołowska, Katarzyna Gruszczyńska, Ewa Emich-Widera
    Brain Sciences.2020; 10(11): 849.     CrossRef
  • Eye of tiger sign in patient with extrapyramidal syndrome - unique case report
    Martin Daniš, Juraj Cisár, Georgi Krastev
    Neurologie pro praxi.2020; 21(4): 319.     CrossRef
  • Early onset developmental delay and epilepsy in pediatric patients with WDR45 variants
    Hongbo Chen, Yanyan Qian, Sha Yu, Deyong Xiao, Xiao Guo, Qing Wang, Lili Hao, Kai Yan, Yulan Lu, Xinran Dong, Wenhao Zhou, Bingbing Wu, Shuizhen Zhou, Huijun Wang
    European Journal of Medical Genetics.2019; 62(2): 149.     CrossRef
  • A new NBIA patient from Turkey with homozygous C19ORF12 mutation
    Çiğdem Seher Kasapkara, Leyla Tümer, Allison Gregory, Fatih Ezgü, Aslı İnci, Betül Emine Derinkuyu, Rachel Fox, Caleb Rogers, Susan Hayflick
    Acta Neurologica Belgica.2019; 119(4): 623.     CrossRef
  • Substantia Nigra Swelling and Dentate Nucleus T2 Hyperintensity May Be Early Magnetic Resonance Imaging Signs of β-Propeller Protein-Associated Neurodegeneration
    Camilla Russo, Anna Ardissone, Elena Freri, Serena Gasperini, Marco Moscatelli, Giovanna Zorzi, Celeste Panteghini, Barbara Castellotti, Barbara Garavaglia, Nardo Nardocci, Luisa Chiapparini
    Movement Disorders Clinical Practice.2019; 6(1): 51.     CrossRef
  • A Golgi-targeting fluorescent probe for labile Fe(ii) to reveal an abnormal cellular iron distribution induced by dysfunction of VPS35
    Tasuku Hirayama, Masatoshi Inden, Hitomi Tsuboi, Masato Niwa, Yasuhiro Uchida, Yuki Naka, Isao Hozumi, Hideko Nagasawa
    Chemical Science.2019; 10(5): 1514.     CrossRef
  • Iron in Neurodegeneration – Cause or Consequence?
    Alain Ndayisaba, Christine Kaindlstorfer, Gregor K. Wenning
    Frontiers in Neuroscience.2019;[Epub]     CrossRef
  • Aceruloplasminemia: A Severe Neurodegenerative Disorder Deserving an Early Diagnosis
    Giacomo Marchi, Fabiana Busti, Acaynne Lira Zidanes, Annalisa Castagna, Domenico Girelli
    Frontiers in Neuroscience.2019;[Epub]     CrossRef
  • FAHN/SPG35: a narrow phenotypic spectrum across disease classifications
    Tim W Rattay, Tobias Lindig, Jonathan Baets, Katrien Smets, Tine Deconinck, Anne S Söhn, Konstanze Hörtnagel, Kathrin N Eckstein, Sarah Wiethoff, Jennifer Reichbauer, Marion Döbler-Neumann, Ingeborg Krägeloh-Mann, Michaela Auer-Grumbach, Barbara Plecko, A
    Brain.2019; 142(6): 1561.     CrossRef
  • Juvenile parkinsonism: Differential diagnosis, genetics, and treatment
    Nicki Niemann, Joseph Jankovic
    Parkinsonism & Related Disorders.2019; 67: 74.     CrossRef
  • Woodhouse–Sakati Syndrome: First report of a Portuguese case
    Pedro Louro, João Durães, Diana Oliveira, Sandra Paiva, Lina Ramos, Maria Carmo Macário
    American Journal of Medical Genetics Part A.2019; 179(11): 2237.     CrossRef
  • Patterns of neurological manifestations in Woodhouse-Sakati Syndrome
    Saeed Bohlega, Ali H. Abusrair, Fahad S. Al-Ajlan, Norah Alharbi, Abdulaziz Al-Semari, Balsam Bohlega, Dalya Abualsaud, Fowzan Alkuraya
    Parkinsonism & Related Disorders.2019; 69: 99.     CrossRef
  • Clinical case of a rare neurodegenerative disease with iron accumulation in the brain, type 4, in a 15-year-old child
    I. F. Fedoseeva, T. V. Poponnikova, G. Yu. Galieva, S. V. Moschnegootz
    Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics).2019; 64(5): 109.     CrossRef
  • Levodopa-induced dyskinesias in mitochondrial membrane protein–associated neurodegeneration
    Daniel Savitt, Joseph Jankovic
    Neurology: Clinical Practice.2019; 9(1): e7.     CrossRef
  • On the complexity of clinical and molecular bases of neurodegeneration with brain iron accumulation
    C. Tello, A. Darling, V. Lupo, B. Pérez-Dueñas, C. Espinós
    Clinical Genetics.2018; 93(4): 731.     CrossRef
  • Les mouvements anormaux : mise au point
    M. Béreau, C. Tranchant
    La Revue de Médecine Interne.2018; 39(8): 641.     CrossRef
  • Ferrosenescence: The iron age of neurodegeneration?
    Adonis Sfera, Kelsey Bullock, Amy Price, Luzmin Inderias, Carolina Osorio
    Mechanisms of Ageing and Development.2018; 174: 63.     CrossRef
  • Chemodosimeters and chemoreactands for sensing ferric ions
    Karl J. Wallace, Ashley D. G. Johnson, W. Scott Jones, Erendra Manandhar
    Supramolecular Chemistry.2018; 30(5-6): 353.     CrossRef
  • Beta-propeller protein-associated neurodegeneration: a case report and review of the literature
    Kjersti Eline Stige, Ivar Otto Gjerde, Gunnar Houge, Per Morten Knappskog, Charalampos Tzoulis
    Clinical Case Reports.2018; 6(2): 353.     CrossRef
  • Looking Deep into the Eye-of-the-Tiger in Pantothenate Kinase–Associated Neurodegeneration
    J.-H. Lee, A. Gregory, P. Hogarth, C. Rogers, S.J. Hayflick
    American Journal of Neuroradiology.2018; 39(3): 583.     CrossRef
  • Novel PLA2G6 mutations and clinical heterogeneity in Chinese cases with phospholipase A2-associated neurodegeneration
    Yi-Jun Chen, Yu-Chao Chen, Hai-Lin Dong, Li-Xi Li, Wang Ni, Hong-Fu Li, Zhi-Ying Wu
    Parkinsonism & Related Disorders.2018;[Epub]     CrossRef
  • Expanding the phenotype of SLC25A42 -associated mitochondrial encephalomyopathy
    M. Almannai, A. Alasmari, A. Alqasmi, E. Faqeih, F. Al Mutairi, M. Alotaibi, M.M. Samman, W. Eyaid, Y.I. Aljadhai, H.E. Shamseldin, W. Craigen, F.S. Alkuraya
    Clinical Genetics.2018; 93(5): 1097.     CrossRef
  • Basal ganglia calcification and novel compound heterozygous mutations in the PANK2 gene in a Chinese boy with classic Pantothenate kinase-associated neurodegeneration
    Xulai Shi, Feixia Zheng, Xiuyun Ye, Xiucui Li, Qianlei Zhao, Zhongdong Lin, Ying Hu, Jiwen Wang
    Medicine.2018; 97(15): e0316.     CrossRef
  • Botulinum toxin injection to improve functional independence and to alleviate parenting stress in a child with advanced pantothenate kinase-associated neurodegeneration
    Cho-I Lin, Kuan-Lin Chen, Ta-Shen Kuan, Sheng-Han Lin, Wei-Pin Lin, Yu-Ching Lin
    Medicine.2018; 97(20): e10709.     CrossRef
  • Expanding the Spectrum of Dopa-Responsive Dystonia (DRD) and Proposal for New Definition: DRD, DRD-plus, and DRD Look-alike
    Woong-Woo Lee, Beomseok Jeon, Ryul Kim
    Journal of Korean Medical Science.2018;[Epub]     CrossRef
  • Oxidative stress and neurodegeneration: the involvement of iron
    Alessia Carocci, Alessia Catalano, Maria Stefania Sinicropi, Giuseppe Genchi
    BioMetals.2018; 31(5): 715.     CrossRef
  • Non-cell-autonomous actions of α-synuclein: Implications in glial synucleinopathies
    Somin Lim, Han-Joon Kim, Dong-Kyu Kim, Seung-Jae Lee
    Progress in Neurobiology.2018; 169: 158.     CrossRef
  • Longitudinal study of multiple sclerosis lesions using ultra-high field (7T) multiparametric MR imaging
    Sanjeev Chawla, Ilya Kister, Tim Sinnecker, Jens Wuerfel, Jean-Christophe Brisset, Friedemann Paul, Yulin Ge, Quan Jiang
    PLOS ONE.2018; 13(9): e0202918.     CrossRef
  • Brain MR Imaging Findings in Woodhouse-Sakati Syndrome
    A.H. Abusrair, S. Bohlega, A. Al-Semari, F.S. Al-Ajlan, K. Al-Ahmadi, B. Mohamed, A. AlDakheel
    American Journal of Neuroradiology.2018; 39(12): 2256.     CrossRef
  • The Involvement of Iron in Traumatic Brain Injury and Neurodegenerative Disease
    Maria Daglas, Paul A. Adlard
    Frontiers in Neuroscience.2018;[Epub]     CrossRef
  • Imaging of dentate nucleus pathologies; a pictorial essay
    Kajari Bhattacharya, Hima Pendharkar, Arun K Gupta
    Indian Journal of Radiology and Imaging.2018; 28(02): 152.     CrossRef
  • Identification of Novel Compound Mutations in PLA2G6-Associated Neurodegeneration Patient with Characteristic MRI Imaging
    Sen Guo, Liu Yang, Huijie Liu, Wei Chen, Jinchen Li, Ping Yu, Zhong Sheng Sun, Xiang Chen, Jie Du, Tao Cai
    Molecular Neurobiology.2017; 54(6): 4636.     CrossRef
  • Serum Ferritin Levels Are Lower in Children With Tic Disorders Compared with Children Without Tics: A Cross-Sectional Study
    Matan Avrahami, Ran Barzilay, Miki HarGil, Abraham Weizman, Nathan Watemberg
    Journal of Child and Adolescent Psychopharmacology.2017; 27(2): 192.     CrossRef
  • Autres syndromes parkinsoniens
    Christine Tranchant
    La Presse Médicale.2017; 46(2): 210.     CrossRef
  • Ferrous Iron Up-regulation in Fibroblasts of Patients with Beta Propeller Protein-Associated Neurodegeneration (BPAN)
    Rosaria Ingrassia, Maurizio Memo, Barbara Garavaglia
    Frontiers in Genetics.2017;[Epub]     CrossRef
  • Radiological Findings of Two Sisters with Aceruloplasminemia Presenting with Chorea
    H. K. Kim, C. S. Ki, Y. J. Kim, M. S. Lee
    Clinical Neuroradiology.2017; 27(3): 385.     CrossRef
  • Mitochondrial membrane protein-associated neurodegeneration
    Angela Deutschländer, Takuya Konno, Owen A. Ross
    Parkinsonism & Related Disorders.2017; 39: 1.     CrossRef
  • Intragenic deletion of the WDR45 gene in a male with encephalopathy, severe psychomotor disability, and epilepsy
    Sylvia Redon, Caroline Benech, Sacha Schutz, Aurore Despres, Paul Gueguen, Pauline Le Berre, Cédric Le Marechal, Sylviane Peudenier, Philippe Meriot, Philippe Parent, Claude Ferec
    American Journal of Medical Genetics Part A.2017; 173(5): 1444.     CrossRef
  • Clinical and Imaging Presentation of a Patient with Beta-Propeller Protein-Associated Neurodegeneration, a Rare and Sporadic form of Neurodegeneration with Brain Iron Accumulation (NBIA)
    Elke Hattingen, Nikolaus Handke, Kirsten Cremer, Sabine Hoffjan, Guido Matthias Kukuk
    Clinical Neuroradiology.2017; 27(4): 481.     CrossRef
  • Dentate Update: Imaging Features of Entities That Affect the Dentate Nucleus
    K.M. Bond, W. Brinjikji, L.J. Eckel, D.F. Kallmes, R.J. McDonald, C.M. Carr
    American Journal of Neuroradiology.2017; 38(8): 1467.     CrossRef
  • Available treatment options for dystonia
    Isabel Alfradique-Dunham, Joseph Jankovic
    Expert Opinion on Orphan Drugs.2017; 5(9): 707.     CrossRef
  • Clinical rating scale for pantothenate kinase-associated neurodegeneration: A pilot study
    Alejandra Darling, Cristina Tello, María Josep Martí, Cristina Garrido, Sergio Aguilera-Albesa, Miguel Tomás Vila, Itziar Gastón, Marcos Madruga, Luis González Gutiérrez, Julio Ramos Lizana, Montserrat Pujol, Tania Gavilán Iglesias, Kylee Tustin, Jean Pie
    Movement Disorders.2017; 32(11): 1620.     CrossRef
  • iPSC-derived neuronal models of PANK2-associated neurodegeneration reveal mitochondrial dysfunction contributing to early disease
    Charles Arber, Plamena R. Angelova, Sarah Wiethoff, Yugo Tsuchiya, Francesca Mazzacuva, Elisavet Preza, Kailash P. Bhatia, Kevin Mills, Ivan Gout, Andrey Y. Abramov, John Hardy, James A. Duce, Henry Houlden, Selina Wray, Fanis Missirlis
    PLOS ONE.2017; 12(9): e0184104.     CrossRef
  • Presynaptic Dopaminergic Degeneration in a Patient with Beta-Propeller Protein-Associated Neurodegeneration Documented by Dopamine Transporter Positron Emission Tomography Images: A Case Report
    Min Ki Kim, Nan Young Kim, Sangkyoon Hong, Hyeo-Il Ma, Yun Joong Kim
    Journal of Movement Disorders.2017; 10(3): 161.     CrossRef
  • Iron in neurodegenerative disorders: being in the wrong place at the wrong time?
    Sotirios Apostolakis, Anna-Maria Kypraiou
    Reviews in the Neurosciences.2017; 28(8): 893.     CrossRef
  • Lessons from a pair of siblings with BPAN
    Yuri A Zarate, Julie R Jones, Melanie A Jones, Francisca Millan, Jane Juusola, Annette Vertino-Bell, G Bradley Schaefer, Michael C Kruer
    European Journal of Human Genetics.2016; 24(7): 1080.     CrossRef
  • “Eye of tiger sign” mimic in an adolescent boy with mitochondrial membrane protein associated neurodegeneration (MPAN)
    Sangeetha Yoganathan, Sniya Valsa Sudhakar, Maya Thomas, Atanu Kumar Dutta, Sumita Danda
    Brain and Development.2016; 38(5): 516.     CrossRef
  • Gene co-expression networks shed light into diseases of brain iron accumulation
    Conceição Bettencourt, Paola Forabosco, Sarah Wiethoff, Moones Heidari, Daniel M. Johnstone, Juan A. Botía, Joanna F. Collingwood, John Hardy, Elizabeth A. Milward, Mina Ryten, Henry Houlden
    Neurobiology of Disease.2016; 87: 59.     CrossRef
  • Brain iron accumulation affects myelin-related molecular systems implicated in a rare neurogenetic disease family with neuropsychiatric features
    M Heidari, D M Johnstone, B Bassett, R M Graham, A C G Chua, M J House, J F Collingwood, C Bettencourt, H Houlden, M Ryten, J K Olynyk, D Trinder, E A Milward
    Molecular Psychiatry.2016; 21(11): 1599.     CrossRef
  • WDR45 mutations in Rett (-like) syndrome and developmental delay: Case report and an appraisal of the literature
    Sabine Hoffjan, Aysegül Ibisler, Anne Tschentscher, Gabriele Dekomien, Carla Bidinost, Alberto L. Rosa
    Molecular and Cellular Probes.2016;[Epub]     CrossRef
  • Missions of <italic>Journal of Movement Disorders</italic>
    Yun Joong Kim
    Journal of Movement Disorders.2016; 9(1): 1.     CrossRef
  • Clinical Heterogeneity of Atypical Pantothenate Kinase-Associated Neurodegeneration in Koreans
    Jae-Hyeok Lee, Jongkyu Park, Ho-Sung Ryu, Hyeyoung Park, Young Eun Kim, Jin Yong Hong, Sang Ook Nam, Young-Hee Sung, Seung-Hwan Lee, Jee-Young Lee, Myung Jun Lee, Tae-Hyoung Kim, Chul Hyoung Lyoo, Sun Ju Chung, Seong Beom Koh, Phil Hyu Lee, Jin Whan Cho,
    Journal of Movement Disorders.2016; 9(1): 20.     CrossRef
  • «Et høist mærkeligt Sygdomstilfælde hos flere Sødskende» – en norsk førstegangsbeskrivelse fra 1830?
    Magne Nylenna, Noralv Breivik, Arvid Heiberg, Øivind Larsen
    Tidsskrift for Den norske legeforening.2016; 136(5): 437.     CrossRef
  • Woodhouse-Sakati Syndrome: Report of the First Tunisian Family with the C2orf37 Gene Mutation
    Olfa Hdiji, Emna Turki, Nouha Bouzidi, Imen Bouchhima, Mariem Damak, Saeed Bohlega, Chokri Mhiri
    Journal of Movement Disorders.2016; 9(2): 120.     CrossRef
  • Encefalopatie metaboliche e tossiche non farmacologiche
    P. Codron, C. Verny
    EMC - Neurologia.2016; 16(3): 1.     CrossRef
  • Iron and Non-Iron-Related Characteristics of Multiple Sclerosis and Neuromyelitis Optica Lesions at 7T MRI
    S. Chawla, I. Kister, J. Wuerfel, J.- C. Brisset, S. Liu, T. Sinnecker, P. Dusek, E. M. Haacke, F. Paul, Y. Ge
    American Journal of Neuroradiology.2016; 37(7): 1223.     CrossRef
  • Freezing of gait in Parkinson's disease: from pathophysiology to emerging therapies
    Alberto Cucca, Milton C Biagioni, Jori E Fleisher, Shashank Agarwal, Andre Son, Pawan Kumar, Miroslaw Brys, Alessandro Di Rocco
    Neurodegenerative Disease Management.2016; 6(5): 431.     CrossRef
  • Neurodegeneration with brain iron accumulation
    João Carlos Papaterra Limongi
    Arquivos de Neuro-Psiquiatria.2016; 74(7): 517.     CrossRef
  • Neurodegeneration with brain iron accumulation: A case report
    Daniel Nassif, João Santos Pereira, Mariana Spitz, Cláudia Capitão, Alessandra Faria
    Dementia & Neuropsychologia.2016; 10(2): 160.     CrossRef
  • What’s in a name? Problems, facts and controversies regarding neurological eponyms
    Hélio A. G. Teive, Plínio M. G. Lima, Francisco M. B. Germiniani, Renato P. Munhoz
    Arquivos de Neuro-Psiquiatria.2016; 74(5): 423.     CrossRef
  • A diagnostic approach for neurodegeneration with brain iron accumulation: clinical features, genetics and brain imaging
    Rubens Paulo Araújo Salomão, José Luiz Pedroso, Maria Thereza Drumond Gama, Lívia Almeida Dutra, Ricardo Horta Maciel, Clécio Godeiro-Junior, Hsin Fen Chien, Hélio A. G. Teive, Francisco Cardoso, Orlando G. P. Barsottini
    Arquivos de Neuro-Psiquiatria.2016; 74(7): 587.     CrossRef
  • Novel homozygous PANK2 mutation identified in a consanguineous Chinese pedigree with pantothenate kinase-associated neurodegeneration
    Yan-Fang Li, Hong-Fu Li, Yan-Bin Zhang, Ji-Min Wu
    Biomedical Reports.2016; 5(2): 217.     CrossRef
  • NBIA - neurodegeneration with brain iron accumulation
    Lenka Hvizdošová, Michaela Kaiserová, Petr Kaňovský, Marek Baláž
    Neurologie pro praxi.2016; 17(5): 328.     CrossRef
  • Orally Bioavailable Metal Chelators and Radical Scavengers: Multifunctional Antioxidants for the Coadjutant Treatment of Neurodegenerative Diseases
    Hiroyoshi Kawada, Peter F. Kador
    Journal of Medicinal Chemistry.2015; 58(22): 8796.     CrossRef
  • Voxel-based analysis in neuroferritinopathy expands the phenotype and determines radiological correlates of disease severity
    M. J. Keogh, B. S. Aribisala, J. He, E. Tulip, D. Butteriss, C. Morris, G. Gorman, R. Horvath, P. F. Chinnery, Andrew M. Blamire
    Journal of Neurology.2015; 262(10): 2232.     CrossRef
  • A field guide to current advances in paediatric movement disorders
    Laura Silveira-Moriyama, Jean-Pierre Lin
    Current Opinion in Neurology.2015; 28(4): 437.     CrossRef
  • En mann i 50-årene med høyt ferritinnivå og økende kognitiv svikt
    Marte-Helene Bjørk, Ivar Otto Gjerde, Charalampos Tzoulis, Rune Johan Ulvik, Laurence Albert Bindoff
    Tidsskrift for Den norske legeforening.2015; 135(15): 1369.     CrossRef
  • Iron, Aging, and Neurodegeneration
    Dafina Angelova, David Brown
    Metals.2015; 5(4): 2070.     CrossRef
Many Faces of Parkinson’s Disease: Non-Motor Symptoms of Parkinson’s Disease
Hye Mi Lee, Seong-Beom Koh
J Mov Disord. 2015;8(2):92-97.   Published online May 31, 2015
DOI: https://doi.org/10.14802/jmd.15003
  • 20,236 View
  • 515 Download
  • 84 Citations
AbstractAbstract PDF
Parkinson’s disease (PD) is a multi-systemic disorder that is characterized by a combination of motor and non-motor symptoms (NMS). The dopaminergic neurodegeneration of PD is involved in the genesis of NMS, but other conditions and side effects of levodopa are also associated with NMS. NMS can develop at all stage of PD and rapid eyeball movement sleep behavior disorder (RBD), constipation, depression, and olfactory dysfunction are considered prodromal signs of PD. Many NMS related with motor deficits and cognitive dysfunction. Some NMS including olfactory dysfunction, RBD and abnormal stereopsis are associated with presence of other NMS of PD. In addition, several NMS can be helpful to differentiate between idiopathic PD and other parkinsonian disorders. Early recognition and management of NMS in PD patients is important for preserving quality of life.

Citations

Citations to this article as recorded by  
  • Neuroprotective effect of anethole against rotenone induced non-motor deficits and oxidative stress in rat model of Parkinson’s disease
    Sadegh Moradi Vastegani, Seyed Esmaeil Khoshnam, Esrafil Mansouri, Somayeh Hajipour, Samireh Ghafouri, Nima Bakhtiari, Alireza Sarkaki, Yaghoob Farbood
    Behavioural Brain Research.2023; 437: 114100.     CrossRef
  • The effects of synbiotic supplementation on oxidative stress markers, mental status, and quality of life in patients with Parkinson’s disease: A double-blind, placebo-controlled, randomized controlled trial
    Sanaz Mehrabani, Fariborz Khorvash, Zahra Heidari, Maryam Tajabadi-Ebrahimi, Reza Amani
    Journal of Functional Foods.2023; 100: 105397.     CrossRef
  • Role of Ceramides and Sphingolipids in Parkinson's Disease
    Melissa Vos, Christine Klein, Andrew A Hicks
    Journal of Molecular Biology.2023; : 168000.     CrossRef
  • Efficacy of herbal medicine treatment based on syndrome differentiation for Parkinson’s disease: A systematic review and meta-analysis of randomized placebo-controlled clinical trials
    Purumea Jun, HuiYan Zhao, In Chul Jung, Ojin Kwon, Chang-Hyun Han, Jiyoon Won, Jung-Hee Jang
    Frontiers in Pharmacology.2023;[Epub]     CrossRef
  • A meta-analysis of exercise intervention and the effect on Parkinson’s Disease symptoms
    Syed Omar Ahmad, Jason Longhurst, Dana Stiles, Lana Downard, Stephanie Martin
    Neuroscience Letters.2023; 801: 137162.     CrossRef
  • Controlling the Impact of Helicobacter pylori-Related Hyperhomocysteinemia on Neurodegeneration
    Jannis Kountouras, Michael Doulberis, Apostolis Papaefthymiou, Stergios A. Polyzos, Christos Zavos, Evangelos Kazakos, Stergios Arapoglou, Foteini Kyrailidi, Maria C. Mouratidou, Marina Boziki, Elisabeth Vardaka
    Medicina.2023; 59(3): 504.     CrossRef
  • Case management interventions in chronic disease reduce anxiety and depressive symptoms: A systematic review and meta-analysis
    Angelika D. Geerlings, Jules M. Janssen Daalen, Jan H. L. Ypinga, Bastiaan R. Bloem, Marjan J. Meinders, Marten Munneke, Sirwan K. L. Darweesh, Vincenzo De Luca
    PLOS ONE.2023; 18(4): e0282590.     CrossRef
  • Is there any correlation between alpha-synuclein levels in tears and retinal layer thickness in Parkinson's disease?
    Azyadeh Camacho-Ordonez, Amin Cervantes-Arriaga, Mayela Rodríguez-Violante, Ana Jimena Hernandez-Medrano, Selma Alin Somilleda-Ventura, Hector J. Pérez-Cano, Ángel Nava-Castañeda, Oscar Guerrero-Berger
    European Journal of Ophthalmology.2023; : 112067212311737.     CrossRef
  • Bio-synthesized selenium nanoparticles ameliorate Brain oxidative stress in Parkinson disease rat models
    Sanaz Salaramoli, Hamed Amiri, Hamid Reza Joshaghani, Mahmoud Hosseini, Seyed Isaac Hashemy
    Metabolic Brain Disease.2023;[Epub]     CrossRef
  • Therapeutic Approaches to Non-Motor Symptoms of Parkinson's Disease: A Current Update on Preclinical Evidence
    Poornima D.E. Weerasinghe-Mudiyanselage, Sohi Kang, Joong-Sun Kim, Changjong Moon
    Current Neuropharmacology.2023; 21(3): 560.     CrossRef
  • REM sleep behavioral disorder may be an independent risk factor for orthostatic hypotension in Parkinson’s disease
    Kangfu Yin, Chuanbin Zhou, Yongyun Zhu, Weifang Yin, Lei Yin, Bin Liu, Hui Ren, Zhong Xu, Xinglong Yang
    Aging Clinical and Experimental Research.2022; 34(1): 159.     CrossRef
  • Gender Differences and Impact of Autonomic Disturbance on Fatigue and Quality of Life in Parkinson's Disease
    NahushR Bansal, BirinderS Paul, Gunchan Paul, Gagandeep Singh
    Neurology India.2022;[Epub]     CrossRef
  • Exploring Unmet Information Needs of People with Parkinson’s Disease and Their Families: Focusing on Information Sharing in an Online Patient Community
    Hyeon Sik Chu, Hye Young Jang
    International Journal of Environmental Research and Public Health.2022; 19(5): 2521.     CrossRef
  • Gut microbiota and inflammation in Parkinson’s disease: Pathogenetic and therapeutic insights
    Tong Guo, Li Chen
    European Journal of Inflammation.2022; 20: 1721727X2210837.     CrossRef
  • Diffusion Tensor Imaging Reveals Deep Brain Structure Changes in Early Parkinson’s Disease Patients with Various Sleep Disorders
    Yanyan Jiang, Hedi An, Qian Xi, Weiting Yang, Hongrong Xie, Yang Li, Dongya Huang
    Brain Sciences.2022; 12(4): 463.     CrossRef
  • Clinical Aspects of the Differential Diagnosis of Parkinson’s Disease and Parkinsonism
    Hae-Won Shin, Sang-Wook Hong, Young Chul Youn
    Journal of Clinical Neurology.2022; 18(3): 259.     CrossRef
  • Effect of mobile health intervention for self-management on self-efficacy, motor and non-motor symptoms, self-management, and quality of life in people with Parkinson's disease: Randomized controlled trial
    Yusun Park, Sung Reul Kim, Hui Young So, Sungyang Jo, Seung Hyun Lee, Yun su Hwang, Mi Sun Kim, Sun Ju Chung
    Geriatric Nursing.2022; 46: 90.     CrossRef
  • Ghrelin mediated regulation of neurosynaptic transmitters in depressive disorders
    Milind V. Masule, Sumit Rathod, Yogeeta Agrawal, Chandragouda R. Patil, Kartik T. Nakhate, Shreesh Ojha, Sameer N. Goyal, Umesh B. Mahajan
    Current Research in Pharmacology and Drug Discovery.2022; 3: 100113.     CrossRef
  • Psychosis in Parkinson’s Disease: A Lesson from Genetics
    Efthalia Angelopoulou, Anastasia Bougea, Sokratis G. Papageorgiou, Chiara Villa
    Genes.2022; 13(6): 1099.     CrossRef
  • Non-motor manifestation of Parkinson's disease: a cross-sectional study in a teaching hospital in Jordan
    Said Salah Dahbour, Mohammad J. Al Murr, Liyan H. Oweis, Nada T. Al Antary, Maram Mohsen, Safa Al Fegi
    The Egyptian Journal of Neurology, Psychiatry and Neurosurgery.2022;[Epub]     CrossRef
  • Neuroprotective effects of probiotics bacteria on animal model of Parkinson’s disease induced by 6-hydroxydopamine: A behavioral, biochemical, and histological study
    Esmail Alipour Nosrani, Omid Reza Tamtaji, Zahra Alibolandi, Parichehr Sarkar, Mohsen Ghazanfari, Abolfazl Azami Tameh, Mohsen Taghizadeh, Zarrin Banikazemi, Razie Hadavi, Mojtaba Naderi Taheri
    Journal of Immunoassay and Immunochemistry.2021; 42(2): 106.     CrossRef
  • SURINPARK: Safinamide for Urinary Symptoms in Parkinson’s Disease
    Ana Gómez-López, Arantxa Sánchez-Sánchez, Elena Natera-Villalba, Victoria Ros-Castelló, Álvaro Beltrán-Corbellini, Samira Fanjul-Arbós, Isabel Pareés Moreno, José Luis López-Sendon Moreno, Juan Carlos Martínez Castrillo, Araceli Alonso-Canovas
    Brain Sciences.2021; 11(1): 57.     CrossRef
  • People with Parkinson’s Disease: What Symptoms Do They Most Want to Improve and How Does This Change with Disease Duration?
    Rebecca J. Port, Martin Rumsby, Graham Brown, Ian F. Harrison, Anneesa Amjad, Claire J. Bale
    Journal of Parkinson's Disease.2021; 11(2): 715.     CrossRef
  • Rho‐kinase inhibition by fasudil modulates pre‐synaptic vesicle dynamics
    Kim Ann Saal, Carmina Warth Pérez Arias, Anna‐Elisa Roser, Jan Christoph Koch, Mathias Bähr, Silvio O. Rizzoli, Paul Lingor
    Journal of Neurochemistry.2021; 157(4): 1052.     CrossRef
  • A Comprehensive Phenotype of Non-motor Impairments and Distribution of Alpha-Synuclein Deposition in Parkinsonism-Induced Mice by a Combination Injection of MPTP and Probenecid
    Na-Ra Han, Yu-Kang Kim, Sora Ahn, Tae-Yeon Hwang, Hyejung Lee, Hi-Joon Park
    Frontiers in Aging Neuroscience.2021;[Epub]     CrossRef
  • Association of Parkinson’s Disease With Microbes and Microbiological Therapy
    Zhao-Ji Chen, Cheng-Yu Liang, Li-Qing Yang, Si-Min Ren, Yan-Min Xia, Lei Cui, Xiao-Fang Li, Bu-Lang Gao
    Frontiers in Cellular and Infection Microbiology.2021;[Epub]     CrossRef
  • Plasma Lipopolysaccharide-Binding Protein Reflects Risk and Progression of Parkinson’s Disease
    Szu-Ju Chen, Yu-Chiao Chi, Chang-Han Ho, Wei-Shiung Yang, Chin-Hsien Lin
    Journal of Parkinson's Disease.2021; 11(3): 1129.     CrossRef
  • The Importance of Drosophila melanogaster Research to UnCover Cellular Pathways Underlying Parkinson’s Disease
    Melissa Vos, Christine Klein
    Cells.2021; 10(3): 579.     CrossRef
  • Docosahexaenoic and Arachidonic Acids as Neuroprotective Nutrients throughout the Life Cycle
    Verónica Sambra, Francisca Echeverria, Alfonso Valenzuela, Raphaël Chouinard-Watkins, Rodrigo Valenzuela
    Nutrients.2021; 13(3): 986.     CrossRef
  • What substance P might tell us about the prognosis and mechanism of Parkinson's disease?
    Paola Tirassa, Tommaso Schirinzi, Marcello Raspa, Massimo Ralli, Antonio Greco, Antonella Polimeni, Roberta Possenti, Nicola Biagio Mercuri, Cinzia Severini
    Neuroscience & Biobehavioral Reviews.2021; 131: 899.     CrossRef
  • Baicalein alleviates depression-like behavior in rotenone- induced Parkinson's disease model in mice through activating the BDNF/TrkB/CREB pathway
    Xiaoyue Zhao, Dewen Kong, Qimeng Zhou, Guangyi Wei, Junke Song, Yu Liang, Guanhua Du
    Biomedicine & Pharmacotherapy.2021; 140: 111556.     CrossRef
  • Apathy and actions- another consideration when theorizing about embodied nature of language in Parkinson's disease
    Logan Wolff, Jared F. Benge, Samia Ortiz-Hernandez, Samantha Beevers, Alexandra Armitage, Jungjun Park, Daniel L. Drane
    Journal of Communication Disorders.2021; 93: 106144.     CrossRef
  • Association analysis and polygenic risk score evaluation of 38 GWAS-identified Loci in a Chinese population with Parkinson’s disease
    Ran Zheng, Song Qiao, Ying Chen, Chongyao Jin, Yi Fang, Zhihao Lin, Naijia Xue, Yiqun Yan, Luyan Gu, Ting Gao, Jun Tian, Yaping Yan, Xinzhen Yin, Jiali Pu, Baorong Zhang
    Neuroscience Letters.2021; 762: 136150.     CrossRef
  • Non-motor impairments affect walking kinematics in Parkinson disease patients: A cross-sectional study
    Sara Liguori, Antimo Moretti, Angela Palomba, Marco Paoletta, Francesca Gimigliano, Rosa De Micco, Mattia Siciliano, Alessandro Tessitore, Giovanni Iolascon
    NeuroRehabilitation.2021; 49(3): 481.     CrossRef
  • The role of gut dysbiosis in Parkinson’s disease: mechanistic insights and therapeutic options
    Qing Wang, Yuqi Luo, K Ray Chaudhuri, Richard Reynolds, Eng-King Tan, Sven Pettersson
    Brain.2021; 144(9): 2571.     CrossRef
  • Clinical features contributing to the sit-to-stand transfer in people with Parkinson’s disease: a systematic review
    Charmaine Pearl Da Cunha, Pratiksha Tilak Rao, Suruliraj Karthikbabu
    The Egyptian Journal of Neurology, Psychiatry and Neurosurgery.2021;[Epub]     CrossRef
  • Integration of Aluminium Interdigitated Electrodes with Zinc Oxide as Nanocomposite for Selectively Detect Alpha-Synuclein for Parkinson’s Disease Diagnosis
    Hussaini Adam, Subash C. B Gopinath, Uda Hashim
    Journal of Physics: Conference Series.2021; 2129(1): 012094.     CrossRef
  • Effects of depression and exercise on health-related quality of life in patients with Parkinson's disease
    George W Koutsouras, Kimberly Levine, Nathalie Duroseau, Christina Ciraco, Vivian Chan, Kathleen Pergament, Thomas Chan, Jayme D Mancini, Adena N Leder, Bhuma Krishnamachari
    Chronic Illness.2020; 16(3): 190.     CrossRef
  • Glial Cell Line–Derived Neurotrophic Factor Receptor Rearranged During Transfection Agonist Supports Dopamine NeuronsIn Vitroand Enhances Dopamine ReleaseIn Vivo
    Arun Kumar Mahato, Jaakko Kopra, Juho‐Matti Renko, Tanel Visnapuu, Ilari Korhonen, Nita Pulkkinen, Maxim M. Bespalov, Andrii Domanskyi, Eric Ronken, T. Petteri Piepponen, Merja H. Voutilainen, Raimo K. Tuominen, Mati Karelson, Yulia A. Sidorova, Mart Saar
    Movement Disorders.2020; 35(2): 245.     CrossRef
  • Early transcranial direct current stimulation treatment exerts neuroprotective effects on 6-OHDA-induced Parkinsonism in rats
    Xiao-Jun Feng, Yu-Ting Huang, Ying-Zu Huang, Chi-Wei Kuo, Chih-Wei Peng, Alexander Rotenberg, Chi-Hung Juan, Yu-Cheng Pei, Yuan-Hao Chen, Kai-Yun Chen, Yung-Hsiao Chiang, Hui-Hua Liu, Jian-Xian Wu, Tsung-Hsun Hsieh
    Brain Stimulation.2020; 13(3): 655.     CrossRef
  • Dizziness in patients with early stages of Parkinson's disease: Prevalence, clinical characteristics and implications
    Kyum‐Yil Kwon, Suyeon Park, Mina Lee, Hyunjin Ju, Kayeong Im, Byung‐Euk Joo, Kyung Bok Lee, Hakjae Roh, Moo‐Young Ahn
    Geriatrics & Gerontology International.2020; 20(5): 443.     CrossRef
  • The Dysfunctional Autonomic Function and “Dysfunctional” Fatigue in Drug Naïve Parkinson’s Disease
    Jong Hyeon Ahn, Minkyeong Kim, Jun Kyu Mun, Yoonsu Cho, Ji Sun Kim, Jinyoung Youn, Joong-Seok Kim, Jin Whan Cho
    Journal of Parkinson's Disease.2020; 10(2): 605.     CrossRef
  • Assessments of plasma acyl-ghrelin levels in Parkinson’s disease patients treated with deep brain stimulation
    Wojciech Pietraszko, Agata Furgala, Agnieszka Gorecka-Mazur, Borys Kwinta, Jolanta Kaszuba-Zwoinska, Jaroslaw Polak, Urszula Fiszer, Krzysztof Gil, Anna Krygowska-Wajs
    Peptides.2020; 128: 170299.     CrossRef
  • Common and unique connectivity at the interface of motor, neuropsychiatric, and cognitive symptoms in Parkinson's disease: A commonality analysis
    Stefan Lang, Zahinoor Ismail, Mekale Kibreab, Iris Kathol, Justyna Sarna, Oury Monchi
    Human Brain Mapping.2020; 41(13): 3749.     CrossRef
  • Systems Biology Approaches to Understand the Host–Microbiome Interactions in Neurodegenerative Diseases
    Dorines Rosario, Jan Boren, Mathias Uhlen, Gordon Proctor, Dag Aarsland, Adil Mardinoglu, Saeed Shoaie
    Frontiers in Neuroscience.2020;[Epub]     CrossRef
  • Rpt2 proteasome subunit reduction causes Parkinson's disease like symptoms in Drosophila
    Iván Fernández-Cruz, Iván Sánchez-Díaz, Verónica Narváez-Padilla, Enrique Reynaud
    IBRO Reports.2020; 9: 65.     CrossRef
  • Boxing to Improve Sleep Quality and Daytime Sleepiness in Individuals With Parkinson Disease
    Macy Urrutia, Cynthia Ivy, Patricia S. Pohl, Linda Denney
    Topics in Geriatric Rehabilitation.2020; 36(3): 170.     CrossRef
  • Effects of the probiotic formulation SLAB51 in in vitro and in vivo Parkinson’s disease models
    Vanessa Castelli, Michele d’Angelo, Francesca Lombardi, Margherita Alfonsetti, Andrea Antonosante, Mariano Catanesi, Elisabetta Benedetti, Paola Palumbo, Maria Grazia Cifone, Antonio Giordano, Giovambattista Desideri, Annamaria Cimini
    Aging.2020; 12(5): 4641.     CrossRef
  • Depressive symptoms are associated with worse cognitive prognosis in patients with newly diagnosed idiopathic Parkinson disease
    Jeong Hoon Park, Seung Hwan Lee, Yeshin Kim, Sang‐Won Park, Gi Hwan Byeon, Jae‐Won Jang
    Psychogeriatrics.2020; 20(6): 880.     CrossRef
  • Lack of association between dopamine transporter loss and non-motor symptoms in patients with Parkinson’s disease: a detailed PET analysis of 12 striatal subregions
    Soo Bin Park, Kyum-Yil Kwon, Jeong-Yoon Lee, Kayeong Im, Jun-Sang Sunwoo, Kyung Bok Lee, Hakjae Roh, Moo-Young Ahn, Suyeon Park, Soo-Jong Kim, Jungsu S. Oh, Jae Seung Kim
    Neurological Sciences.2019; 40(2): 311.     CrossRef
  • Cognitive Problems in Parkinson Disease: Perspectives and Priorities of Patients and Care Partners
    Katrina L. Raein, Samia Ortiz-Hernández, Jared F. Benge
    Cognitive and Behavioral Neurology.2019; 32(1): 16.     CrossRef
  • Probiotics mixture increases butyrate, and subsequently rescues the nigral dopaminergic neurons from MPTP and rotenone-induced neurotoxicity
    Sunil Srivastav, Sabita Neupane, Sunil Bhurtel, Nikita Katila, Sailesh Maharjan, Hyukjae Choi, Jin Tae Hong, Dong-Young Choi
    The Journal of Nutritional Biochemistry.2019; 69: 73.     CrossRef
  • Asymptomatic Hearing Impairment Frequently Occurs in Early-Onset Parkinson’s Disease
    Kuldeep Shetty, Syam Krishnan, Jissa Vinoda Thulaseedharan, Manju Mohan, Asha Kishore
    Journal of Movement Disorders.2019; 12(2): 84.     CrossRef
  • Detecting Non-cognitive Features of Prodromal Neurodegenerative Diseases
    Alon Seifan, Christine A. Ganzer, Krista Ryon, Michael Lin, Rahman Mahmudur, Henriquez Adolfo, Cindy Shih, Alan R. Jacobs, Molly Greenwald, Richard S. Isaacson
    Current Aging Science.2019; 11(4): 242.     CrossRef
  • Elevated Serum Homocysteine Levels Have Differential Gender-Specific Associations with Motor and Cognitive States in Parkinson’s Disease
    Megan C. Bakeberg, Alexa Jefferson, Maddeson Riley, Michelle Byrnes, Soumya Ghosh, Frank L. Mastaglia, Malcom K. Horne, Sarah McGregor, Rick Stell, Jade Kenna, Sue Walters, Dana Hince, Ryan S. Anderton
    Parkinson's Disease.2019; 2019: 1.     CrossRef
  • α-Synuclein in Parkinson’s disease: causal or bystander?
    Peter Riederer, Daniela Berg, Nicolas Casadei, Fubo Cheng, Joseph Classen, Christian Dresel, Wolfgang Jost, Rejko Krüger, Thomas Müller, Heinz Reichmann, Olaf Rieß, Alexander Storch, Sabrina Strobel, Thilo van Eimeren, Hans-Ullrich Völker, Jürgen Winkler,
    Journal of Neural Transmission.2019; 126(7): 815.     CrossRef
  • Selegiline Recovers Synaptic Plasticity in the Medial Prefrontal Cortex and Improves Corresponding Depression-Like Behavior in a Mouse Model of Parkinson’s Disease
    Motoki Okano, Kazue Takahata, Junya Sugimoto, Shizuko Muraoka
    Frontiers in Behavioral Neuroscience.2019;[Epub]     CrossRef
  • Inner retinal thinning as a biomarker for cognitive impairment in de novo Parkinson’s disease
    Mi Sun Sung, Seong-Min Choi, Jonghwa Kim, Jun Young Ha, Byeong-Chae Kim, Hwan Heo, Sang Woo Park
    Scientific Reports.2019;[Epub]     CrossRef
  • Probiotics for Parkinson’s Disease
    Gazerani
    International Journal of Molecular Sciences.2019; 20(17): 4121.     CrossRef
  • The Role of the Gut Microbiota in the Pathogenesis of Parkinson's Disease
    Dongming Yang, Deming Zhao, Syed Zahid Ali Shah, Wei Wu, Mengyu Lai, Xixi Zhang, Jie Li, Zhiling Guan, Huafen Zhao, Wen Li, Hongli Gao, Xiangmei Zhou, Lifeng Yang
    Frontiers in Neurology.2019;[Epub]     CrossRef
  • Long-Term Voluntary Physical Exercise Exerts Neuroprotective Effects and Motor Disturbance Alleviation in a Rat Model of Parkinson’s Disease
    Wan-Ling Tsai, Hsin-Yung Chen, Ying-Zu Huang, Yuan-Hao Chen, Chi-Wei Kuo, Kai-Yun Chen, Tsung-Hsun Hsieh
    Behavioural Neurology.2019; 2019: 1.     CrossRef
  • The effectiveness of istradefylline for the treatment of gait deficits and sleepiness in patients with Parkinson’s disease
    Keita Matsuura, Hiroyuki Kajikawa, Ken-ichi Tabei, Masayuki Satoh, Hirotaka Kida, Naoko Nakamura, Hidekazu Tomimoto
    Neuroscience Letters.2018; 662: 158.     CrossRef
  • Predictors of Mortality in Nondemented Patients With Parkinson Disease: Motor Symptoms Versus Nonmotor Symptoms
    D. Santos-García, E. Suárez-Castro, J. Ernandez, I. Expósito-Ruiz, C. Tuñas-Gesto, M. Aneiros-Díaz, T. de Deus-Fonticoba, M. López-Fernández, D. Núñez-Arias
    Journal of Geriatric Psychiatry and Neurology.2018; 31(1): 19.     CrossRef
  • Additive Effects of Levodopa and a Neurorestorative Diet in a Mouse Model of Parkinson’s Disease
    Paula Perez-Pardo, Laus M. Broersen, Tessa Kliest, Nick van Wijk, Amos Attali, Johan Garssen, Aletta D. Kraneveld
    Frontiers in Aging Neuroscience.2018;[Epub]     CrossRef
  • Ghrelin and Neurodegenerative Disorders—a Review
    Limin Shi, Xixun Du, Hong Jiang, Junxia Xie
    Molecular Neurobiology.2017; 54(2): 1144.     CrossRef
  • The neurological effects of ghrelin in brain diseases: Beyond metabolic functions
    Qian Jiao, Xixun Du, Yong Li, Bing Gong, Limin Shi, Tingting Tang, Hong Jiang
    Neuroscience & Biobehavioral Reviews.2017; 73: 98.     CrossRef
  • First-in-human assessment of PRX002, an anti-α-synuclein monoclonal antibody, in healthy volunteers
    Dale B. Schenk, Martin Koller, Daniel K. Ness, Sue G. Griffith, Michael Grundman, Wagner Zago, Jay Soto, George Atiee, Susanne Ostrowitzki, Gene G. Kinney
    Movement Disorders.2017; 32(2): 211.     CrossRef
  • Normal ‘heart’ in Parkinson's disease: is this a distinct clinical phenotype?
    J.-S. Kim, H.-E. Park, I.-S. Park, Y.-S. Oh, D.-W. Ryu, I.-U. Song, Y.-A. Jung, I. R. Yoo, H.-S. Choi, P. H. Lee, K.-S. Lee
    European Journal of Neurology.2017; 24(2): 349.     CrossRef
  • α-Synuclein in the colon and premotor markers of Parkinson disease in neurologically normal subjects
    Joong-Seok Kim, In-Seok Park, Hyung-Eun Park, Su-Young Kim, Jung A Yun, Chan Kwon Jung, Hye-Young Sung, Jin-Kwon Lee, Won-Kyung Kang
    Neurological Sciences.2017; 38(1): 171.     CrossRef
  • Use of monoamine oxidase inhibitors in chronic neurodegeneration
    Peter Riederer, Thomas Müller
    Expert Opinion on Drug Metabolism & Toxicology.2017; 13(2): 233.     CrossRef
  • Validation of the Korean Version of the Scale for Outcomes in Parkinson’s Disease-Autonomic
    Ji-Young Kim, In-Uk Song, Seong-Beom Koh, Tae-Beom Ahn, Sang Jin Kim, Sang-Myung Cheon, Jin Whan Cho, Yun Joong Kim, Hyeo-Il Ma, Mee-Young Park, Jong Sam Baik, Phil Hyu Lee, Sun Ju Chung, Jong-Min Kim, Han-Joon Kim, Young-Hee Sung, Do Young Kwon, Jae-Hyeo
    Journal of Movement Disorders.2017; 10(1): 29.     CrossRef
  • Retinal biomarkers provide “insight” into cortical pharmacology and disease
    Christine T.O. Nguyen, Flora Hui, Jason Charng, Shajan Velaedan, Anna K. van Koeverden, Jeremiah K.H. Lim, Zheng He, Vickie H.Y. Wong, Algis J. Vingrys, Bang V. Bui, Magnus Ivarsson
    Pharmacology & Therapeutics.2017; 175: 151.     CrossRef
  • Promising Effects of Neurorestorative Diets on Motor, Cognitive, and Gastrointestinal Dysfunction after Symptom Development in a Mouse Model of Parkinson's Disease
    Paula Perez-Pardo, Esther M. de Jong, Laus M. Broersen, Nick van Wijk, Amos Attali, Johan Garssen, Aletta D. Kraneveld
    Frontiers in Aging Neuroscience.2017;[Epub]     CrossRef
  • DaT-SPECT assessment depicts dopamine depletion among asymptomatic G2019S LRRK2 mutation carriers
    Moran Artzi, Einat Even-Sapir, Hedva Lerman Shacham, Avner Thaler, Avi Orr Urterger, Susan Bressman, Karen Marder, Talma Hendler, Nir Giladi, Dafna Ben Bashat, Anat Mirelman, Elisa Greggio
    PLOS ONE.2017; 12(4): e0175424.     CrossRef
  • The gut-brain axis in Parkinson's disease: Possibilities for food-based therapies
    Paula Perez-Pardo, Tessa Kliest, Hemraj B. Dodiya, Laus M. Broersen, Johan Garssen, Ali Keshavarzian, Aletta D. Kraneveld
    European Journal of Pharmacology.2017; 817: 86.     CrossRef
  • Who Can Diagnose Parkinson's Disease First? Role of Pre-motor Symptoms
    Mayela Rodríguez-Violante, Rosalía Zerón-Martínez, Amin Cervantes-Arriaga, Teresa Corona
    Archives of Medical Research.2017; 48(3): 221.     CrossRef
  • Microbes Tickling Your Tummy: the Importance of the Gut-Brain Axis in Parkinson’s Disease
    Paula Perez-Pardo, Mitch Hartog, Johan Garssen, Aletta D. Kraneveld
    Current Behavioral Neuroscience Reports.2017; 4(4): 361.     CrossRef
  • The Therapeutic Potential of Exercise to Improve Mood, Cognition, and Sleep in Parkinson's Disease
    Gretchen O. Reynolds, Michael W. Otto, Terry D. Ellis, Alice Cronin-Golomb
    Movement Disorders.2016; 31(1): 23.     CrossRef
  • Orthostatic hypotension and cardiac sympathetic denervation in Parkinson disease patients with REM sleep behavioral disorder
    Joong-Seok Kim, Hyung-Eun Park, Yoon-Sang Oh, Si-Hoon Lee, Jeong-Wook Park, Byung-chul Son, Kwang-Soo Lee
    Journal of the Neurological Sciences.2016; 362: 59.     CrossRef
  • Relearning of Writing Skills in Parkinson's Disease After Intensive Amplitude Training
    Evelien Nackaerts, Elke Heremans, Griet Vervoort, Bouwien C.M. Smits‐Engelsman, Stephan P. Swinnen, Wim Vandenberghe, Bruno Bergmans, Alice Nieuwboer
    Movement Disorders.2016; 31(8): 1209.     CrossRef
  • Cardiovascular Autonomic Dysfunction in Mild and Advanced Parkinson’s Disease
    Joong-Seok Kim, Si-Hoon Lee, Yoon-Sang Oh, Jeong-Wook Park, Jae-Young An, Sung-Kyung Park, Si-Ryung Han, Kwang-Soo Lee
    Journal of Movement Disorders.2016; 9(2): 97.     CrossRef
  • The KMDS-NATION Study: Korean Movement Disorders Society Multicenter Assessment of Non-Motor Symptoms and Quality of Life in Parkinson's Disease NATION Study Group
    Do-Young Kwon, Seong-Beom Koh, Jae Hyeok Lee, Hee Kyung Park, Han-Joon Kim, Hae-Won Shin, Jinyoung Youn, Kun Woo Park, Sun-Ah Choi, Sang Jin Kim, Seong-Min Choi, Ji-Yun Park, Beom S. Jeon, Ji Young Kim, Sun Ju Chung, Chong Sik Lee, Jeong-Ho Park, Tae-Beom
    Journal of Clinical Neurology.2016; 12(4): 393.     CrossRef
  • Bent out of shape: α-Synuclein misfolding and the convergence of pathogenic pathways in Parkinson's disease
    Esteban Luna, Kelvin C. Luk
    FEBS Letters.2015; 589(24PartA): 3749.     CrossRef
  • Differentiated Cells Derived from Fetal Neural Stem Cells Improve Motor Deficits in a Rat Model of Parkinson's Disease
    Wei Wang, Hao Song, Aifang Shen, Chao Chen, Yanming Liu, Yabing Dong, Fabin Han
    Translational Neuroscience and Clinics.2015; 1(2): 75.     CrossRef
Original Article
Exosome-Based Delivery of miR-124 in a Huntington’s Disease Model
Soon-Tae Lee, Wooseok Im, Jae-Jun Ban, Mijung Lee, Keun-Hwa Jung, Sang Kun Lee, Kon Chu, Manho Kim
J Mov Disord. 2017;10(1):45-52.   Published online January 18, 2017
DOI: https://doi.org/10.14802/jmd.16054
  • 13,939 View
  • 357 Download
  • 79 Citations
AbstractAbstract PDF
Objective
Huntington’s disease (HD) is a genetic neurodegenerative disease that is caused by abnormal CAG expansion. Altered microRNA (miRNA) expression also causes abnormal gene regulation in this neurodegenerative disease. The delivery of abnormally downregulated miRNAs might restore normal gene regulation and have a therapeutic effect.
Methods
We developed an exosome-based delivery method to treat this neurodegenerative disease. miR-124, one of the key miRNAs that is repressed in HD, was stably overexpressed in a stable cell line. Exosomes were then harvested from these cells using an optimized protocol. The exosomes (Exo-124) exhibited a high level of miR-124 expression and were taken up by recipient cells.
Results
When Exo-124 was injected into the striatum of R6/2 transgenic HD mice, expression of the target gene, RE1-Silencing Transcription Factor, was reduced. However, Exo-124 treatment did not produce significant behavioral improvement.
Conclusion
This study serves as a proof of concept for exosome-based delivery of miRNA in neurodegenerative diseases.

Citations

Citations to this article as recorded by  
  • Exosomal microRNAs as diagnostic biomarkers and therapeutic applications in neurodegenerative diseases
    Xuehereti Sataer, Zhu Qifeng, Zhang Yingying, He Chunhua, Feng Bingzhenga, Xu Zhiran, Li Wanli, Yang Yuwei, Chen Shuangfeng, Wu Lingling, Huang Hongri, Chen Jibing, Ren Xiaoping, Gao Hongjun
    Neurological Research.2023; 45(3): 191.     CrossRef
  • The role of microRNAs in neurodegenerative diseases: a review
    Shijie Li, Zhixin Lei, Taolei Sun
    Cell Biology and Toxicology.2023; 39(1): 53.     CrossRef
  • Exosomes based strategies for brain drug delivery
    Fawad Ur Rehman, Yang Liu, Meng Zheng, Bingyang Shi
    Biomaterials.2023; 293: 121949.     CrossRef
  • Contribution of Extracellular Vesicles and Molecular Chaperones in Age-Related Neurodegenerative Disorders of the CNS
    Leila Noori, Kamila Filip, Zohreh Nazmara, Simin Mahakizadeh, Gholamreza Hassanzadeh, Celeste Caruso Bavisotto, Fabio Bucchieri, Antonella Marino Gammazza, Francesco Cappello, Maciej Wnuk, Federica Scalia
    International Journal of Molecular Sciences.2023; 24(2): 927.     CrossRef
  • Nucleic acid drug vectors for diagnosis and treatment of brain diseases
    Zhi-Guo Lu, Jie Shen, Jun Yang, Jing-Wen Wang, Rui-Chen Zhao, Tian-Lu Zhang, Jing Guo, Xin Zhang
    Signal Transduction and Targeted Therapy.2023;[Epub]     CrossRef
  • Exosome-Based Carrier for RNA Delivery: Progress and Challenges
    Yicheng Lu, Wei Huang, Meng Li, Aiping Zheng
    Pharmaceutics.2023; 15(2): 598.     CrossRef
  • MicroRNA‑124: an emerging therapeutic target in central nervous system disorders
    Wen-Hao Zhang, Lian Jiang, Mei Li, Jing Liu
    Experimental Brain Research.2023; 241(5): 1215.     CrossRef
  • The role of exosomes in pathogenesis and the therapeutic efficacy of mesenchymal stem cell-derived exosomes against Parkinson’s disease
    Maryam Abrishamdar, Maryam Sadat Jalali, Neda Yazdanfar
    Neurological Sciences.2023;[Epub]     CrossRef
  • Small Extracellular Vesicles’ miRNAs: Biomarkers and Therapeutics for Neurodegenerative Diseases
    Wei Qing Lim, Kie Hoon Michelle Luk, Kah Yee Lee, Nasuha Nurul, Sin Jade Loh, Zhen Xiong Yeow, Qi Xuan Wong, Qi Hao Daniel Looi, Pan Pan Chong, Chee Wun How, Sharina Hamzah, Jhi Biau Foo
    Pharmaceutics.2023; 15(4): 1216.     CrossRef
  • Bioengineered Mesenchymal-Stromal-Cell-Derived Extracellular Vesicles as an Improved Drug Delivery System: Methods and Applications
    Cristiana Ulpiano, Cláudia L. da Silva, Gabriel A. Monteiro
    Biomedicines.2023; 11(4): 1231.     CrossRef
  • Mmu-miR-25-3p promotes macrophage autophagy by targeting DUSP10 to reduce mycobacteria survival
    Wenqi Yuan, Xuehua Zhan, Wei Liu, Rong Ma, Yueyong Zhou, Guangxian Xu, Zhaohui Ge
    Frontiers in Cellular and Infection Microbiology.2023;[Epub]     CrossRef
  • Exosomes as cell-derivative carriers in the diagnosis and treatment of central nervous system diseases
    Gayatri Gopal Shetgaonkar, Shirleen Miriam Marques, Cleona E. M. DCruz, R. J. A. Vibhavari, Lalit Kumar, Rupesh Kalidas Shirodkar
    Drug Delivery and Translational Research.2022; 12(5): 1047.     CrossRef
  • Emerging prospects of extracellular vesicles for brain disease theranostics
    Ruoning Wang, Xiaohong Wang, Yuting Zhang, Huacong Zhao, Jiwei Cui, Junsong Li, Liuqing Di
    Journal of Controlled Release.2022; 341: 844.     CrossRef
  • Stem Cell Transplantation Therapy and Neurological Disorders: Current Status and Future Perspectives
    Md. Rahman, Md. Islam, Mohammad Islam, Md. Harun-Or-Rashid, Mahfuzul Islam, Sabirin Abdullah, Mohammad Uddin, Sumit Das, Md. Rahaman, Muniruddin Ahmed, Fahad Alhumaydhi, Talha Emran, Amany Mohamed, Mohammad Faruque, Mayeen Khandaker, Gomaa Mostafa-Hedeab
    Biology.2022; 11(1): 147.     CrossRef
  • Non-viral vectors for RNA delivery
    Yi Yan, Xiao-Yu Liu, An Lu, Xiang-Yu Wang, Lin-Xia Jiang, Jian-Cheng Wang
    Journal of Controlled Release.2022; 342: 241.     CrossRef
  • MicroRNA-22: a Novel and Potent Biological Therapeutics in Neurological Disorders
    Seyed Hamidreza Rastegar-moghaddam, Alireza Ebrahimzadeh-Bideskan, Sara Shahba, Amir Mohammad Malvandi, Abbas Mohammadipour
    Molecular Neurobiology.2022; 59(5): 2694.     CrossRef
  • Functional Extracellular Vesicles for Regenerative Medicine
    Han Young Kim, Seunglee Kwon, Wooram Um, Sol Shin, Chan Ho Kim, Jae Hyung Park, Byung‐Soo Kim
    Small.2022; 18(36): 2106569.     CrossRef
  • Emerging role of exosomes in the pathology of chronic obstructive pulmonary diseases; destructive and therapeutic properties
    Hadi Rajabi, Nur Konyalilar, Sinem Erkan, Deniz Mortazavi, Seval Kubra Korkunc, Ozgecan Kayalar, Hasan Bayram, Reza Rahbarghazi
    Stem Cell Research & Therapy.2022;[Epub]     CrossRef
  • MicroRNA Alteration, Application as Biomarkers, and Therapeutic Approaches in Neurodegenerative Diseases
    T. P. Nhung Nguyen, Mandeep Kumar, Ernesto Fedele, Giambattista Bonanno, Tiziana Bonifacino
    International Journal of Molecular Sciences.2022; 23(9): 4718.     CrossRef
  • Protective Signature of IFNγ-Stimulated Microglia Relies on miR-124-3p Regulation From the Secretome Released by Mutant APP Swedish Neuronal Cells
    Gonçalo Garcia, Adelaide Fernandes, Frank Stein, Dora Brites
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Therapeutic Potential of Exosomes Derived from Diabetic Adipose Stem Cells in Cutaneous Wound Healing of db/db Mice
    Hsiang-Hao Hsu, Aline Yen Ling Wang, Charles Yuen Yung Loh, Ashwin Alke Pai, Huang-Kai Kao
    Pharmaceutics.2022; 14(6): 1206.     CrossRef
  • Recent progresses in exosome-based systems for targeted drug delivery to the brain
    Santosh Bashyal, Chhitij Thapa, Sangkil Lee
    Journal of Controlled Release.2022; 348: 723.     CrossRef
  • MicroRNA-124 attenuates PTSD-like behaviors and reduces the level of inflammatory cytokines by downregulating the expression of TRAF6 in the hippocampus of rats following single-prolonged stress
    Yao Chen, Qi An, Shu-Ting Yang, Yu-Lu Chen, Lei Tong, Li-Li Ji
    Experimental Neurology.2022; 356: 114154.     CrossRef
  • Exosomes─Nature’s Lipid Nanoparticles, a Rising Star in Drug Delivery and Diagnostics
    Rumiana Tenchov, Janet M. Sasso, Xinmei Wang, Wen-Shing Liaw, Chun-An Chen, Qiongqiong Angela Zhou
    ACS Nano.2022; 16(11): 17802.     CrossRef
  • The emerging role of long non-coding RNAs, microRNAs, and an accelerated epigenetic age in Huntington’s disease
    Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Mohammad Taheri, Kaveh Ebrahimzadeh, Rezvan Noroozi
    Frontiers in Aging Neuroscience.2022;[Epub]     CrossRef
  • Intracellular and intercellular transport of RNA organelles in CXG repeat disorders: The strength of weak ties
    Deepti Kailash Nabariya, Annika Heinz, Sabrina Derksen, Sybille Krauß
    Frontiers in Molecular Biosciences.2022;[Epub]     CrossRef
  • Extracellular vesicles in neurodegenerative diseases: Insights and new perspectives
    Qian Yuan, Xiao-dong Li, Si-miao Zhang, Hong-wei Wang, Yun-liang Wang
    Genes & Diseases.2021; 8(2): 124.     CrossRef
  • Therapeutic antisense oligonucleotides for movement disorders
    Epaminondas Doxakis
    Medicinal Research Reviews.2021; 41(5): 2656.     CrossRef
  • An update on the role of miR-124 in the pathogenesis of human disorders
    Soudeh Ghafouri-Fard, Hamed Shoorei, Zahra Bahroudi, Atefe Abak, Jamal Majidpoor, Mohammad Taheri
    Biomedicine & Pharmacotherapy.2021; 135: 111198.     CrossRef
  • Ancient Evolutionary Origin and Properties of Universally Produced Natural Exosomes Contribute to Their Therapeutic Superiority Compared to Artificial Nanoparticles
    Phillip W. Askenase
    International Journal of Molecular Sciences.2021; 22(3): 1429.     CrossRef
  • Intriguing Biomedical Applications of Synthetic and Natural Cell-Derived Vesicles: A Comparative Overview
    Brateen Datta, Debashish Paul, Uttam Pal, Tatini Rakshit
    ACS Applied Bio Materials.2021; 4(4): 2863.     CrossRef
  • Nucleic acid delivery with extracellular vesicles
    Michaela Schulz-Siegmund, Achim Aigner
    Advanced Drug Delivery Reviews.2021; 173: 89.     CrossRef
  • Emerging Roles of Exosomes in Huntington’s Disease
    Hanadi Ananbeh, Petr Vodicka, Helena Kupcova Skalnikova
    International Journal of Molecular Sciences.2021; 22(8): 4085.     CrossRef
  • Stem Cell-Derived Exosomes: a New Strategy of Neurodegenerative Disease Treatment
    Nashmin Fayazi, Mohsen Sheykhhasan, Sara Soleimani Asl, Rezvan Najafi
    Molecular Neurobiology.2021; 58(7): 3494.     CrossRef
  • Altered microRNA expression in animal models of Huntington’s disease and potential therapeutic strategies
    Bridget Martinez, PhilipV Peplow
    Neural Regeneration Research.2021; 16(11): 2159.     CrossRef
  • Roles of glia-derived extracellular vesicles in central nervous system diseases: an update
    Hao Sun, Xiaojuan Su, Shiping Li, Dezhi Mu, Yi Qu
    Reviews in the Neurosciences.2021; 32(8): 833.     CrossRef
  • Oligonucleotides as therapeutic tools for brain disorders: Focus on major depressive disorder and Parkinson's disease
    Analia Bortolozzi, Sharon Manashirov, Alon Chen, Francesc Artigas
    Pharmacology & Therapeutics.2021; 227: 107873.     CrossRef
  • Perspective insights and application of exosomes as a novel tool against neurodegenerative disorders: An expository appraisal
    Amey Kadbhane, Monica Patel, Saurabh Srivastava, Pankaj Kumar Singh, Jitender Madan, Shashi Bala Singh, Dharmendra Kumar Khatri
    Journal of Drug Delivery Science and Technology.2021; 63: 102526.     CrossRef
  • Harnessing the therapeutic potential of extracellular vesicles for cancer treatment
    Ying Zhang, Yu Xiao, Gaoge Sun, Xue Jin, Lerui Guo, Tian Li, Hang Yin
    Seminars in Cancer Biology.2021; 74: 92.     CrossRef
  • Neural Stem Cell-Derived Exosomes Regulate Neural Stem Cell Differentiation Through miR-9-Hes1 Axis
    Ping Yuan, Lu Ding, Huili Chen, Yi Wang, Chunhong Li, Shu Zhao, Xiaoyu Yang, Yizhao Ma, Jie Zhu, Xinrui Qi, Yanyan Zhang, Xiaohuan Xia, Jialin C. Zheng
    Frontiers in Cell and Developmental Biology.2021;[Epub]     CrossRef
  • Diagnostic and Therapeutic Potential of Exosomal MicroRNAs for Neurodegenerative Diseases
    Miao He, Hai-nan Zhang, Zhen-chu Tang, Shu-guang Gao, Laura Baroncelli
    Neural Plasticity.2021; 2021: 1.     CrossRef
  • Profiling of Extracellular Small RNAs Highlights a Strong Bias towards Non-Vesicular Secretion
    Helena Sork, Mariana Conceicao, Giulia Corso, Joel Nordin, Yi Xin Fiona Lee, Kaarel Krjutskov, Jakub Orzechowski Westholm, Pieter Vader, Marie Pauwels, Roosmarijn E. Vandenbroucke, Matthew JA Wood, Samir EL Andaloussi, Imre Mäger
    Cells.2021; 10(6): 1543.     CrossRef
  • Neuroinflammation: The next target of exosomal microRNAs derived from mesenchymal stem cells in the context of neurological disorders
    Mehrdad Hajinejad, Sajad Sahab‐Negah
    Journal of Cellular Physiology.2021; 236(12): 8070.     CrossRef
  • Exosomal microRNAs from mesenchymal stem/stromal cells: Biology and applications in neuroprotection
    Aida Nasirishargh, Priyadarsini Kumar, Lalithasri Ramasubramanian, Kaitlin Clark, Dake Hao, Sabrina V Lazar, Aijun Wang
    World Journal of Stem Cells.2021; 13(7): 776.     CrossRef
  • Central Nervous System Cell-Derived Exosomes in Neurodegenerative Diseases
    Yang Tian, Chen Fu, Yifan Wu, Yao Lu, Xuemei Liu, Yunling Zhang, Yanfang Xian
    Oxidative Medicine and Cellular Longevity.2021; 2021: 1.     CrossRef
  • The regulatory roles of microRNAs toward pathogenesis and treatments in Huntington's disease
    Chih-Wei Tung, Pin-Yu Huang, Siew Chin Chan, Pei-Hsun Cheng, Shang-Hsun Yang
    Journal of Biomedical Science.2021;[Epub]     CrossRef
  • Dosing extracellular vesicles
    Dhanu Gupta, Antje Maria Zickler, Samir El Andaloussi
    Advanced Drug Delivery Reviews.2021; 178: 113961.     CrossRef
  • Therapeutic Potential of Nucleic Acids when Combined with Extracellular Vesicles
    Brian Jurgielewicz, Steven Stice, Yao Yao
    Aging and disease.2021; 12(6): 1476.     CrossRef
  • Effects of exosomal miRNAs in the diagnosis and treatment of Alzheimer’s disease
    Guo-hong Cui, Jing Zhu, Ya-chao Wang, Jing Wu, Jian-ren Liu, Hai-dong Guo
    Mechanisms of Ageing and Development.2021; 200: 111593.     CrossRef
  • MicroRNA-124: A Key Player in Microglia-Mediated Inflammation in Neurological Diseases
    Jiuhan Zhao, Zhenwei He, Jialu Wang
    Frontiers in Cellular Neuroscience.2021;[Epub]     CrossRef
  • DNAJB6b-enriched small extracellular vesicles decrease polyglutamine aggregation in in vitro and in vivo models of Huntington disease
    Bhagyashree S. Joshi, Sameh A. Youssef, Reinier Bron, Alain de Bruin, Harm H. Kampinga, Inge S. Zuhorn
    iScience.2021; 24(11): 103282.     CrossRef
  • Diagnostic and Therapeutic Potential of Exosomes in Neurodegenerative Diseases
    Panyue Gao, Xinrong Li, Xinzhe Du, Sha Liu, Yong Xu
    Frontiers in Aging Neuroscience.2021;[Epub]     CrossRef
  • MiR-124 and the Underlying Therapeutic Promise of Neurodegenerative Disorders
    Dong Han, Xiaoyu Dong, Dongming Zheng, Jianfei Nao
    Frontiers in Pharmacology.2020;[Epub]     CrossRef
  • Circulating Exosomal miRNA as Diagnostic Biomarkers of Neurodegenerative Diseases
    Lin Wang, Lijuan Zhang
    Frontiers in Molecular Neuroscience.2020;[Epub]     CrossRef
  • Current Status of microRNA-Based Therapeutic Approaches in Neurodegenerative Disorders
    Sujay Paul, Luis Alberto Bravo Vázquez, Samantha Pérez Uribe, Paula Roxana Reyes-Pérez, Ashutosh Sharma
    Cells.2020; 9(7): 1698.     CrossRef
  • Progress in the molecular pathogenesis and nucleic acid therapeutics for Parkinson's disease in the precision medicine era
    Dunhui Li, Frank L. Mastaglia, Sue Fletcher, Steve D. Wilton
    Medicinal Research Reviews.2020; 40(6): 2650.     CrossRef
  • MicroRNAs Dysregulation and Mitochondrial Dysfunction in Neurodegenerative Diseases
    Mariano Catanesi, Michele d’Angelo, Maria Grazia Tupone, Elisabetta Benedetti, Antonio Giordano, Vanessa Castelli, Annamaria Cimini
    International Journal of Molecular Sciences.2020; 21(17): 5986.     CrossRef
  • Exosome engineering: Current progress in cargo loading and targeted delivery
    Shengyang Fu, Yi Wang, Xiaohuan Xia, Jialin C. Zheng
    NanoImpact.2020; 20: 100261.     CrossRef
  • Strategies and materials of "SMART" non-viral vectors: Overcoming the barriers for brain gene therapy
    Yan Li, Linying Liu, Weihong Ji, Huang Peng, Ruichen Zhao, Xin Zhang
    Nano Today.2020; 35: 101006.     CrossRef
  • Therapeutic miRNA-Enriched Extracellular Vesicles: Current Approaches and Future Prospects
    Javaria Munir, Jeong Kyo Yoon, Seongho Ryu
    Cells.2020; 9(10): 2271.     CrossRef
  • The Role of Exosomal microRNAs and Oxidative Stress in Neurodegenerative Diseases
    Xiaoyu Wang, Yunxiang Zhou, Qiannan Gao, Dongnan Ping, Yali Wang, Wei Wu, Xu Lin, Yuanjian Fang, Jianmin Zhang, Anwen Shao, Yanfang Xian
    Oxidative Medicine and Cellular Longevity.2020; 2020: 1.     CrossRef
  • Nanocarriers as a powerful vehicle to overcome blood-brain barrier in treating neurodegenerative diseases: Focus on recent advances
    Xiaoqian Niu, Jiejian Chen, Jianqing Gao
    Asian Journal of Pharmaceutical Sciences.2019; 14(5): 480.     CrossRef
  • Blood exosomes as a tool for monitoring treatment efficacy and progression of neurodegenerative diseases
    Hanin Abdel-Haq
    Neural Regeneration Research.2019; 14(1): 72.     CrossRef
  • MiR-124 Enriched Exosomes Promoted the M2 Polarization of Microglia and Enhanced Hippocampus Neurogenesis After Traumatic Brain Injury by Inhibiting TLR4 Pathway
    Yongxiang Yang, Yuqin Ye, Chuiguang Kong, Xinhong Su, Xin Zhang, Wei Bai, Xiaosheng He
    Neurochemical Research.2019; 44(4): 811.     CrossRef
  • Resveratrol (3, 5, 4′-Trihydroxy-trans-Stilbene) Attenuates a Mouse Model of Multiple Sclerosis by Altering the miR-124/Sphingosine Kinase 1 Axis in Encephalitogenic T Cells in the Brain
    K. Alexa Orr Gandy, Jiajia Zhang, Prakash Nagarkatti, Mitzi Nagarkatti
    Journal of Neuroimmune Pharmacology.2019; 14(3): 462.     CrossRef
  • Advances in therapeutic applications of extracellular vesicles
    Oscar P. B. Wiklander, Meadhbh Á. Brennan, Jan Lötvall, Xandra O. Breakefield, Samir EL Andaloussi
    Science Translational Medicine.2019;[Epub]     CrossRef
  • Exosome-mediated therapeutic delivery: A new horizon for human neurodegenerative disorders’ treatment (with a focus on siRNA delivery improvement)
    Nayer Seyfizadeh, Narges Seyfizadeh, Sajad Borzouisileh, Farideh Elahimanesh, Vahid Hosseini, Mohammad Nouri
    Process Biochemistry.2019; 85: 164.     CrossRef
  • Exosomes released from neural progenitor cells and induced neural progenitor cells regulate neurogenesis through miR-21a
    Yizhao Ma, Chunhong Li, Yunlong Huang, Yi Wang, Xiaohuan Xia, Jialin C. Zheng
    Cell Communication and Signaling.2019;[Epub]     CrossRef
  • Exosomal miRNAs in central nervous system diseases: biomarkers, pathological mediators, protective factors and therapeutic agents
    Xiaohuan Xia, Yi Wang, Yunlong Huang, Han Zhang, Hongfang Lu, Jialin C. Zheng
    Progress in Neurobiology.2019; 183: 101694.     CrossRef
  • Role of Exosomes in Central Nervous System Diseases
    Wanying Liu, Xiaodan Bai, Ao Zhang, Juanjuan Huang, Shixin Xu, Junping Zhang
    Frontiers in Molecular Neuroscience.2019;[Epub]     CrossRef
  • miR-124 and Parkinson’s disease: A biomarker with therapeutic potential
    Efthalia Angelopoulou, Yam Nath Paudel, Christina Piperi
    Pharmacological Research.2019; 150: 104515.     CrossRef
  • The Potential Role of MicroRNA-124 in Cerebral Ischemia Injury
    Xiaolu Liu, Zhitao Feng, Lipeng Du, Yaguang Huang, Jinwen Ge, Yihui Deng, Zhigang Mei
    International Journal of Molecular Sciences.2019; 21(1): 120.     CrossRef
  • Epigenetic regulation of astrocyte function in neuroinflammation and neurodegeneration
    Matthew Neal, Jason R. Richardson
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2018; 1864(2): 432.     CrossRef
  • Potential of Extracellular Vesicles in Neurodegenerative Diseases: Diagnostic and Therapeutic Indications
    Mehrnaz Izadpanah, Arshia Seddigh, Somayeh Ebrahimi Barough, Seyed Abolhassan Shahzadeh Fazeli, Jafar Ai
    Journal of Molecular Neuroscience.2018; 66(2): 172.     CrossRef
  • Regenerative Approaches in Huntington’s Disease: From Mechanistic Insights to Therapeutic Protocols
    Jenny Sassone, Elsa Papadimitriou, Dimitra Thomaidou
    Frontiers in Neuroscience.2018;[Epub]     CrossRef
  • Exosome-based small RNA delivery: progress and prospects
    Mei Lu, Haonan Xing, Zhe Xun, Tianzhi Yang, Pingtian Ding, Cuifang Cai, Dongkai Wang, Xiaoyun Zhao
    Asian Journal of Pharmaceutical Sciences.2017;[Epub]     CrossRef
  • Extracellular Vesicles in Brain Tumors and Neurodegenerative Diseases
    Federica Ciregia, Andrea Urbani, Giuseppe Palmisano
    Frontiers in Molecular Neuroscience.2017;[Epub]     CrossRef
  • The miR-124 family of microRNAs is critical for regeneration of the brain and visual system in the planarian Schmidtea mediterranea
    Sasidharan Vidyanand, Srujan Marepally, Sarah A. Elliott, Srishti Baid, Vairavan Lakshmanan, Nishtha Nayyar, Dhiru Bansal, Alejandro Sánchez Alvarado, Praveen Kumar Vemula, Dasaradhi Palakodeti
    Development.2017;[Epub]     CrossRef
  • Mutant Huntingtin Inhibits αB-Crystallin Expression and Impairs Exosome Secretion from Astrocytes
    Yan Hong, Ting Zhao, Xiao-Jiang Li, Shihua Li
    The Journal of Neuroscience.2017; 37(39): 9550.     CrossRef
Review Articles
What Is Wrong with Balance in Parkinson’s Disease?
Jeong-Ho Park, Yeo-Jeong Kang, Fay Bahling Horak
J Mov Disord. 2015;8(3):109-114.   Published online September 10, 2015
DOI: https://doi.org/10.14802/jmd.15018
  • 22,283 View
  • 372 Download
  • 72 Citations
AbstractAbstract PDF
Postural instability and resulting falls are major factors determining quality of life, morbidity, and mortality in individuals with Parkinson’s disease (PD). A better understanding of balance impairments would improve management of balance dysfunction and prevent falls in patients with PD. The effects of bradykinesia, rigidity, impaired proprioception, freezing of gait and attention on postural stability in patients with idiopathic PD have been well characterized in laboratory studies. The purpose of this review is to systematically summarize the types of balance impairments contributing to postural instability in people with PD.

Citations

Citations to this article as recorded by  
  • Assessing perceptions to a virtual reality intervention to improve trunk control in Parkinson’s disease: a preliminary study
    Alexander Stamenkovic, Matthew Underation, Leslie J. Cloud, Peter E. Pidcoe, Mark S. Baron, Robert Hand, Christopher R. France, Susanne M. van der Veen, James S. Thomas
    Virtual Reality.2023; 27(1): 465.     CrossRef
  • Association of Depression With Early Occurrence of Postural Instability in Parkinson’s Disease
    Yun Su Hwang, Sungyang Jo, Kye Won Park, Seung Hyun Lee, Sangjin Lee, Sun Ju Chung
    Journal of Movement Disorders.2023; 16(1): 68.     CrossRef
  • Clinical and MRI features of gait and balance disorders in neurodegenerative diseases
    Elisabetta Sarasso, Massimo Filippi, Federica Agosta
    Journal of Neurology.2023; 270(3): 1798.     CrossRef
  • Effects of Oral Levodopa on Balance in People with Idiopathic Parkinson’s Disease
    Tim Leroy, Remco J. Baggen, Nina Lefeber, Nolan Herssens, Patrick Santens, Miet De Letter, Leen Maes, Katie Bouche, Anke Van Bladel
    Journal of Parkinson's Disease.2023; 13(1): 3.     CrossRef
  • The Use of the Static Posturography to Assess Balance Performance in a Parkinson’s Disease Population
    Sergio Sebastia-Amat, Juan Tortosa-Martínez, Basilio Pueo
    International Journal of Environmental Research and Public Health.2023; 20(2): 981.     CrossRef
  • Der Einfluss vom Exergaming mit kommerziell verfügbaren Spielkonsolen auf die Balance und Lebensqualität bei Menschen mit idiopathischem Parkinson-Syndrom – Eine systematische Übersichtsarbeit
    Gaith Akrama, Lennert Sitzmann, Christian Baumann
    physioscience.2023; 19(02): 63.     CrossRef
  • Design of SmartWalk for Estimating Implication of Pathway With Turn and Task Condition on Postural and Gait Indices: Relevance to Fear of Fall
    Priya Pallavi, Neeti Jariwala, Niravkumar Patel, Manasi Kanetkar, Shraddha Diwan, Uttama Lahiri
    IEEE Transactions on Neural Systems and Rehabilitation Engineering.2023; 31: 406.     CrossRef
  • Rehabilitation Interventions for Improving Balance in Parkinson’s Disease
    Francesco Lena, Nicola Modugno, Giulio Greco, Monica Torre, Simone Cesarano, Marco Santilli, Auwal Abdullahi, Giuseppe Giovannico, Mohammad Etoom
    American Journal of Physical Medicine & Rehabilitation.2023; 102(3): 270.     CrossRef
  • Validity and Reliability of the Thai Version of the Freezing of Gait Questionnaire in Individuals With Parkinson’s disease
    Arisa Taweekitikul, Phakamas Tanvijit, Pheeravut Tantisuvanitchkul, Prachaya Srivanitchapoom, Yuvadee Pitakpatapee, Fuengfa Khobkhun, Piyapong Akkathep
    Annals of Rehabilitation Medicine.2023; 47(1): 45.     CrossRef
  • Anticipatory Postural Adjustments and Compensatory Postural Responses to Multidirectional Perturbations—Effects of Medication and Subthalamic Nucleus Deep Brain Stimulation in Parkinson’s Disease
    Tobias Heß, Christian Oehlwein, Thomas L. Milani
    Brain Sciences.2023; 13(3): 454.     CrossRef
  • PRIORITIZING FALL RISK MANAGEMENT: IRRESPECTIVE OF PARKINSON’S DISEASE PROGRESSION DURING REHABILITATION
    Fakhir Ansari
    Pakistan Journal of Rehabilitation.2023; 12(1): 84.     CrossRef
  • Functional balance training in people with Parkinson’s disease: a protocol of balanceHOME randomized control trial with crossover
    Sara Monleón Guinot, Constanza San Martín Valenzuela, Vivina Aranda Asensi, Concepción de Salazar Antón, Manuel Villanueva Navarro, Jose M. Tomás
    Frontiers in Aging Neuroscience.2023;[Epub]     CrossRef
  • Characterizing Freezing of Gait Episodes for Parkinson’s Disease Using a Wearable Device Quantifying Gait and Posture
    Priya Pallavi, Niravkumar Patel, Manasi Kanetkar, Uttama Lahiri
    Journal of Medical and Biological Engineering.2023;[Epub]     CrossRef
  • Dynamic Measures of Balance during a 90° Turn in Self-Selected Gait in Individuals with Mild Parkinson’s Disease
    Gordon Alderink, Cathy Harro, Lauren Hickox, David W. Zeitler, Marie Bourke, Akeya Gosla, Sarah Rustmann
    Applied Sciences.2023; 13(9): 5428.     CrossRef
  • Differences between physical therapist ratings, self-ratings, and posturographic measures when assessing static balance exercise intensity
    Jamie Ferris, Jonathan Zwier, Wendy J. Carender, Kathleen H. Sienko
    Frontiers in Rehabilitation Sciences.2023;[Epub]     CrossRef
  • The influence of cognitive tasks on sensory organization test performance
    Nathan Morelli, Nicholas R. Heebner, Courtney J. DeFeo, Matthew C. Hoch
    Brazilian Journal of Otorhinolaryngology.2022; 88(6): 841.     CrossRef
  • Influence of radial optic flow stimulation on static postural balance in Parkinson's disease: A preliminary study
    Alessandro Piras, Aurelio Trofè, Andrea Meoni, Milena Raffi
    Human Movement Science.2022; 81: 102905.     CrossRef
  • The effect of Tai Chi on functional mobility, balance and falls in Parkinson's disease: A systematic review and meta-analysis of systematic reviews
    Bahar Aras, Gulce Kallem Seyyar, Oznur Fidan, Ertugrul Colak
    EXPLORE.2022; 18(4): 402.     CrossRef
  • Avaliação do risco de quedas entre pessoas com doença de Parkinson
    Franciny da Silva, Angela Maria Alvarez, Simony Fabíola Lopes Nunes, Maria Eduarda Massari Silva, Silvia Maria Azevedo Dos Santos
    Escola Anna Nery.2022;[Epub]     CrossRef
  • Acceptability and Preliminary Results of Technology-Assisted Balance Training in Parkinson’s Disease
    Elvira Maranesi, Valentina Di Donna, Giuseppe Pelliccioni, Valentina Cameriere, Elisa Casoni, Renato Baldoni, Marco Benadduci, Nadia Rinaldi, Lorenzo Fantechi, Cinzia Giammarchi, Riccardo Luzi, Paolo Pelliccioni, Mirko Di Rosa, Pietro Scendoni, Giovanni R
    International Journal of Environmental Research and Public Health.2022; 19(5): 2655.     CrossRef
  • A systematic review on the effectiveness of perturbation-based balance training in postural control and gait in Parkinson’s disease
    Daniel Boari Coelho, Claudia Eunice Neves de Oliveira, Marcos Vinicius Carvalho Guimarães, Caroline Ribeiro de Souza, Márcio Luiz dos Santos, Andrea C. de Lima-Pardini
    Physiotherapy.2022; 116: 58.     CrossRef
  • Therapeutic Implications of Caffeic Acid in Cancer and Neurological Diseases
    Manzar Alam, Sarfraz Ahmed, Abdelbaset Mohamed Elasbali, Mohd Adnan, Shoaib Alam, Md. Imtaiyaz Hassan, Visweswara Rao Pasupuleti
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Rasch Validation of the Mini-BESTest in People With Parkinson Disease
    Franco Franchignoni, Marco Godi, Stefano Corna, Andrea Giordano
    Journal of Neurologic Physical Therapy.2022; 46(3): 219.     CrossRef
  • Factors Contributing to Repeated Falls in Patients with Parkinsonʼs Disease : Focusing on Falls Self-efficacy and Cognition of Punishment
    Yasuomi Tomii, Mika Otsuki, Naoya Hasegawa
    Higher Brain Function Research.2022; 42(1): 29.     CrossRef
  • Short-Term Motor Outcomes in Parkinson’s Disease after Subthalamic Nucleus Deep Brain Stimulation Combined with Post-Operative Rehabilitation: A Pre-Post Comparison Study
    Kazunori Sato, Yoshihide Hokari, Eriko Kitahara, Nana Izawa, Kozo Hatori, Kaoru Honaga, Genko Oyama, Taku Hatano, Hirokazu Iwamuro, Atsushi Umemura, Yasushi Shimo, Nobutaka Hattori, Toshiyuki Fujiwara, Giuseppina Martella
    Parkinson's Disease.2022; 2022: 1.     CrossRef
  • Re-conceptualizing postural control assessment in sport-related concussion: Transitioning from the reflex/hierarchical model to the systems model
    Thaer S. Manaseer, Douglas P. Gross, Martin Mrazik, Kathryn Schneider, Jackie L. Whittaker
    Physiotherapy Theory and Practice.2021; 37(7): 763.     CrossRef
  • Short-term effects of postural control by standing on a tilting board in patients with Parkinson’s disease
    Naoya Hasegawa, Keita Ishikawa, Yuki Sato, Yasuhide Nakayama, Tadayoshi Asaka
    Physiotherapy Theory and Practice.2021; 37(12): 1306.     CrossRef
  • Comparison of the effect of whole-body vibration therapy versus conventional therapy on functional balance of patients with Parkinson’s disease: adding a mixed group
    Eduardo Guadarrama-Molina, Carlos Enrique Barrón-Gámez, Ingrid Estrada-Bellmann, Jesús D. Meléndez-Flores, Paola Ramírez-Castañeda, Rosa María Gisela Hernández-Suárez, Minerva Menchaca-Pérez, Oscar Salas-Fraire
    Acta Neurologica Belgica.2021; 121(3): 721.     CrossRef
  • Impact of Physiotherapy Absence in COVID-19 Pandemic on Neurological State of Patients With Parkinson Disease
    Alen Kapel, Domen Serdoner, Ester Fabiani, Tomaz Velnar
    Topics in Geriatric Rehabilitation.2021; 37(1): 50.     CrossRef
  • The relationship between attention and static balance disturbance in patients with Parkinson’s disease
    Amir Dana, Amir Shams, Nahid Allafan, Alireza Bahrami
    Neurological Sciences.2021; 42(12): 5107.     CrossRef
  • Does the impaired postural control in Parkinson's disease affect the habituation to non-sequential external perturbation trials?
    Victor Spiandor Beretta, Mark Gregory Carpenter, Fabio Augusto Barbieri, Paulo Cezar Rocha Santos, Diego Orcioli-Silva, Marcelo Pinto Pereira, Lilian Teresa Bucken Gobbi
    Clinical Biomechanics.2021; 85: 105363.     CrossRef
  • Abnormal center of mass feedback responses during balance: A potential biomarker of falls in Parkinson’s disease
    J. Lucas McKay, Kimberly C. Lang, Sistania M. Bong, Madeleine E. Hackney, Stewart A. Factor, Lena H. Ting, Manabu Sakakibara
    PLOS ONE.2021; 16(5): e0252119.     CrossRef
  • Establishing the Rotenone-Induced Parkinson's Disease Animal Model in Wistar Albino Rats
    Gangadhara Swamy, Rajendra Holla, Suresh R. Rao
    Journal of Health and Allied Sciences NU.2021; 11(03): 158.     CrossRef
  • Development of a Parkinson’s disease specific falls questionnaire
    Dale M. Harris, Rachel L. Duckham, Robin M. Daly, Gavin Abbott, Liam Johnson, Timo Rantalainen, Wei-Peng Teo
    BMC Geriatrics.2021;[Epub]     CrossRef
  • Correlation between community balance and mobility scale (CB&M) with a battery of outcome measures to assess balance in Parkinson’s disease – a cross-sectional study
    Ziona Lionel Dsouza, Sydney Roshan Rebello, Cherishma Dsilva
    Archives of Physiotherapy.2021;[Epub]     CrossRef
  • Cholinesterase inhibitors for gait, balance, and fall in Parkinson disease: a meta-analysis
    Jia-Hung Chen, Tsai-Wei Huang, Chien-Tai Hong
    npj Parkinson's Disease.2021;[Epub]     CrossRef
  • Dancing With Parkinson's Disease: The SI-ROBOTICS Study Protocol
    Roberta Bevilacqua, Marco Benadduci, Anna Rita Bonfigli, Giovanni Renato Riccardi, Giovanni Melone, Angela La Forgia, Nicola Macchiarulo, Luca Rossetti, Mauro Marzorati, Giovanna Rizzo, Pierpaolo Di Bitonto, Ada Potenza, Laura Fiorini, Federica Gabriella
    Frontiers in Public Health.2021;[Epub]     CrossRef
  • Balance and mobility in patients with newly diagnosed Parkinson’s disease – a five-year follow-up of a cohort in northern Sweden
    Christer Johansson, Britta Lindström, Lars Forsgren, Gudrun M. Johansson
    Disability and Rehabilitation.2020; 42(6): 770.     CrossRef
  • Minimal Detectable Change for Balance Using the Biodex Balance System in Patients with Parkinson Disease
    Jumes Leopoldino Oliveira Lira, Carlos Ugrinowitsch, Rafael Fecchio, Daniel Boari Coelho, Acácio Moreira‐Neto, Renan Germano, Angelo Corrêa Lima Miliatto, Bianca Cristina Santos Vieira Yano, Carla Silva‐Batista
    PM&R.2020; 12(3): 281.     CrossRef
  • Perception of whole-body motion during balance perturbations is impaired in Parkinson's disease and is associated with balance impairment
    Sistania M. Bong, J. Lucas McKay, Stewart A. Factor, Lena H. Ting
    Gait & Posture.2020; 76: 44.     CrossRef
  • Postural impairments in Parkinson’s disease are not associated with changes in circadian rhythms changes
    Luiz Claudio Zulai, André Martinez Albuquerque, Caluê Papcke, Fernando Mazzilli Louzada, Eduardo Mendonça Scheeren
    Chronobiology International.2020; 37(1): 135.     CrossRef
  • Choreographing life-experiences of balance control in people with Parkinson’s disease
    Sofie LaGrone, Conran Joseph, Hanna Johansson, Birgit Enberg, Erika Franzén
    BMC Neurology.2020;[Epub]     CrossRef
  • Effect of home-based Tai Chi, Yoga or conventional balance exercise on functional balance and mobility among persons with idiopathic Parkinson’s disease: An experimental study
    Arva Khuzema, A. Brammatha, V. Arul Selvan
    Hong Kong Physiotherapy Journal.2020; 40(01): 39.     CrossRef
  • A comparison of the relationship between manual dexterity and postural control in young and older individuals with Parkinson’s disease
    Aybuke Cansu Kalkan, Turhan Kahraman, Biron Onur Ugut, Berril Donmez Colakoglu, Arzu Genc
    Journal of Clinical Neuroscience.2020; 75: 89.     CrossRef
  • Explaining Parkinsonian postural sway variabilities using intermittent control theory
    Ranjita Dash, Vrutangkumar V. Shah, Harish J. Palanthandalam-Madapusi
    Journal of Biomechanics.2020; 105: 109791.     CrossRef
  • Rehabilitation of older people with Parkinson’s disease: an innovative protocol for RCT study to evaluate the potential of robotic-based technologies
    Roberta Bevilacqua, Elvira Maranesi, Mirko Di Rosa, Riccardo Luzi, Elisa Casoni, Nadia Rinaldi, Renato Baldoni, Fabrizia Lattanzio, Valentina Di Donna, Giuseppe Pelliccioni, Giovanni Renato Riccardi
    BMC Neurology.2020;[Epub]     CrossRef
  • Assessment of Functional Activities in Individuals with Parkinson’s Disease Using a Simple and Reliable Smartphone-Based Procedure
    Pilar Serra-Añó, José Francisco Pedrero-Sánchez, Marta Inglés, Marta Aguilar-Rodríguez, Ismael Vargas-Villanueva, Juan López-Pascual
    International Journal of Environmental Research and Public Health.2020; 17(11): 4123.     CrossRef
  • New insight into Parkinson’s disease‐related impairment of the automatic control of upright stance
    Cédrick T. Bonnet, Arnaud Delval, Tarkeshwar Singh, Yann‐Romain Kechabia, Luc Defebvre
    European Journal of Neuroscience.2020; 52(12): 4851.     CrossRef
  • Innovative Parkinson's Disease Patients' Motor Skills Assessment: The i-PROGNOSIS Paradigm
    Sofia Balula Dias, Athina Grammatikopoulou, José Alves Diniz, Kosmas Dimitropoulos, Nikos Grammalidis, Vicky Zilidou, Theodore Savvidis, Evdokimos Konstantinidis, Panagiotis D. Bamidis, Hagen Jaeger, Michael Stadtschnitzer, Hugo Silva, Gonçalo Telo, Ioann
    Frontiers in Computer Science.2020;[Epub]     CrossRef
  • Effects of multimodal balance training supported by rhythmical auditory stimuli in people with advanced stages of Parkinson's disease: a pilot randomized clinical trial
    Tamine T.C. Capato, Jorik Nonnekes, Nienke M. de Vries, Joanna IntHout, Egberto R. Barbosa, Bastiaan R. Bloem
    Journal of the Neurological Sciences.2020; 418: 117086.     CrossRef
  • Responsiveness of Objective vs. Clinical Balance Domain Outcomes for Exercise Intervention in Parkinson's Disease
    Naoya Hasegawa, Vrutangkumar V. Shah, Graham Harker, Patricia Carlson-Kuhta, John G. Nutt, Jodi A. Lapidus, Se Hee Jung, Nancy Barlow, Laurie A. King, Fay B. Horak, Martina Mancini
    Frontiers in Neurology.2020;[Epub]     CrossRef
  • Neuroprotective Effects of Coffee Bioactive Compounds: A Review
    Katarzyna Socała, Aleksandra Szopa, Anna Serefko, Ewa Poleszak, Piotr Wlaź
    International Journal of Molecular Sciences.2020; 22(1): 107.     CrossRef
  • Parkinson's Disease and Parkinsonism
    Michael T. Hayes
    The American Journal of Medicine.2019; 132(7): 802.     CrossRef
  • How to Select Balance Measures Sensitive to Parkinson’s Disease from Body-Worn Inertial Sensors—Separating the Trees from the Forest
    Naoya Hasegawa, Vrutangkumar V. Shah, Patricia Carlson-Kuhta, John G. Nutt, Fay B. Horak, Martina Mancini
    Sensors.2019; 19(15): 3320.     CrossRef
  • Treatment options for postural instability and gait difficulties in Parkinson’s disease
    Martijn L.T.M. Müller, Uros Marusic, Miriam van Emde Boas, Daniel Weiss, Nicolaas I. Bohnen
    Expert Review of Neurotherapeutics.2019; 19(12): 1229.     CrossRef
  • A new technique to test the effect of cognition on standing balance in Parkinson’s disease
    M Bhatt, B Mahana, JJ Marotta, JH Ko, T Szturm
    Open Journal of Parkinson's Disease and Treatment.2019; 2(1): 006.     CrossRef
  • Step length determines minimum toe clearance in older adults and people with Parkinson’s disease
    Lisa Alcock, Brook Galna, Ruth Perkins, Sue Lord, Lynn Rochester
    Journal of Biomechanics.2018; 71: 30.     CrossRef
  • Long-term effects of highly challenging balance training in Parkinson’s disease—a randomized controlled trial
    Martin Benka Wallén, Maria Hagströmer, David Conradsson, Kimmo Sorjonen, Erika Franzén
    Clinical Rehabilitation.2018; : 026921551878433.     CrossRef
  • Parkinson's disease versus ageing: different postural responses to soleus muscle vibration
    Diana Bzdúšková, Peter Valkovič, Zuzana Hirjaková, Jana Kimijanová, František Hlavačka
    Gait & Posture.2018; 65: 169.     CrossRef
  • A High-Intensity Multicomponent Agility Intervention Improves Parkinson Patients’ Clinical and Motor Symptoms
    József Tollár, Ferenc Nagy, Norbert Kovács, Tibor Hortobágyi
    Archives of Physical Medicine and Rehabilitation.2018; 99(12): 2478.     CrossRef
  • Parkinson’s disease does not alter automatic visual-motor coupling in postural control
    Caio Ferraz Cruz, Maria Elisa Pimentel Piemonte, Líria Akie Okai-Nobrega, Erika Okamoto, Ana Claudia de Souza Fortaleza, Martina Mancini, Fay Bahling Horak, José Angelo Barela
    Neuroscience Letters.2018; 686: 47.     CrossRef
  • Assessing Walking Adaptability in Parkinson's Disease: “The Interactive Walkway”
    Daphne J. Geerse, Melvyn Roerdink, Johan Marinus, Jacobus J. van Hilten
    Frontiers in Neurology.2018;[Epub]     CrossRef
  • Camptocormia with Transient Ischemic Attack
    Ju-Hee Oh, Dong-Woo Ryu, Si-Hoon Lee, Joong-Seok Kim
    Journal of Movement Disorders.2017; 10(1): 62.     CrossRef
  • Motor dysfunction and alterations in glutathione concentration, cholinesterase activity, and BDNF expression in substantia nigra pars compacta in rats with pedunculopontine lesion
    Lisette Blanco-Lezcano, Javier Jimenez-Martin, Mei-Li Díaz-Hung, Esteban Alberti-Amador, Maylin Wong-Guerra, Ma. Elena González-Fraguela, Bárbara Estupiñán-Díaz, Teresa Serrano-Sánchez, Liliana Francis-Turner, Susana Delgado-Ocaña, Yanier Núñez-Figueredo,
    Neuroscience.2017; 348: 83.     CrossRef
  • Axial rigidity is related to the risk of falls in patients with Parkinson’s disease
    Roberto Cano-de-la-Cuerda, Lydia Vela-Desojo, Juan Carlos Miangolarra-Page, Yolanda Macías-Macías
    NeuroRehabilitation.2017; 40(4): 569.     CrossRef
  • Body Posture, Postural Stability, and Metabolic Age in Patients with Parkinson’s Disease
    Jacek Wilczyński, Agnieszka Pedrycz, Dariusz Mucha, Tadeusz Ambroży, Dawid Mucha
    BioMed Research International.2017; 2017: 1.     CrossRef
  • Investigation of Anticipatory Postural Adjustments during One-Leg Stance Using Inertial Sensors: Evidence from Subjects with Parkinsonism
    Gianluca Bonora, Martina Mancini, Ilaria Carpinella, Lorenzo Chiari, Maurizio Ferrarin, John G. Nutt, Fay B. Horak
    Frontiers in Neurology.2017;[Epub]     CrossRef
  • Altered neurofilament protein expression in the lateral vestibular nucleus in Parkinson’s disease
    Thomas P. Wellings, Alan M. Brichta, Rebecca Lim
    Experimental Brain Research.2017; 235(12): 3695.     CrossRef
  • Biomechanical Analysis of Dance for Parkinson’s Disease: A Paradoxical Case Study of Balance and Gait Effects?
    Kristen L. Sowalsky, Jill Sonke, Lori J.P. Altmann, Leonardo Almeida, Chris J. Hass
    EXPLORE.2017; 13(6): 409.     CrossRef
  • Femur Fractures in Parkinsonism: Analysis of a National Sample Cohort in South Korea
    Soo Jeong An, Seung-Hwan Lee, Seo-Young Lee, Jae-Woo Kwon, Seung-Joon Lee, Young-Ju Kim
    Journal of Clinical Neurology.2017; 13(4): 380.     CrossRef
  • The International Classification of Functioning, Disability and Health as Applied to Parkinson’s Disease: A Literature Review
    Audrin Said Vojciechowski, Talita Gianello Gnoato Zotz, Ana Paula Cunha Loureiro, Vera Lúcia Israel
    Advances in Parkinson's Disease.2016; 05(02): 29.     CrossRef
  • Can Gait Signatures Provide Quantitative Measures for Aiding Clinical Decision-Making? A Systematic Meta-Analysis of Gait Variability Behavior in Patients with Parkinson's Disease
    Niklas König, Navrag B. Singh, Christian R. Baumann, William R. Taylor
    Frontiers in Human Neuroscience.2016;[Epub]     CrossRef
Altered Gut Microbiome and Intestinal Pathology in Parkinson’s Disease
Han-Lin Chiang, Chin-Hsien Lin
J Mov Disord. 2019;12(2):67-83.   Published online May 30, 2019
DOI: https://doi.org/10.14802/jmd.18067
  • 13,736 View
  • 714 Download
  • 57 Citations
AbstractAbstract PDF
Parkinson’s disease (PD) is a common neurodegenerative disorder arising from an interplay between genetic and environmental risk factors. Studies have suggested that the pathological hallmarks of intraneuronal α-synuclein aggregations may start from the olfactory bulb and the enteric nervous system of the gut and later propagate to the brain via the olfactory tract and the vagus nerve. This hypothesis correlates well with clinical symptoms, such as constipation, that may develop up to 20 years before the onset of PD motor symptoms. Recent interest in the gut–brain axis has led to vigorous research into the gastrointestinal pathology and gut microbiota changes in patients with PD. In this review, we provide current clinical and pathological evidence of gut involvement in PD by summarizing the changes in gut microbiota composition and gut inflammation associated with its pathogenesis.

Citations

Citations to this article as recorded by  
  • Adipose tissue, systematic inflammation, and neurodegenerative diseases
    AnaPaula de A. Boleti, PedroHenrique de O. Cardoso, BrenoEmanuel F. Frihling, PatríciaSouza e Silva, LuizFilipe R. N. de Moraes, Ludovico Migliolo
    Neural Regeneration Research.2023; 18(1): 38.     CrossRef
  • Parkinson's Disease: A Multisystem Disorder
    Helena Nunes Costa, Ana Raquel Esteves, Nuno Empadinhas, Sandra Morais Cardoso
    Neuroscience Bulletin.2023; 39(1): 113.     CrossRef
  • Plasma Metabolic Analysis Reveals the Dysregulation of Short-Chain Fatty Acid Metabolism in Parkinson’s Disease
    Ao Qi, Lulu Liu, Junjie Zhang, Simei Chen, Simin Xu, Yusen Chen, Lijiang Zhang, Chun Cai
    Molecular Neurobiology.2023; 60(5): 2619.     CrossRef
  • Fecal microbiota transplantation in Parkinson's disease—A randomized repeat-dose, placebo-controlled clinical pilot study
    Herbert L. DuPont, Jessika Suescun, Zhi-Dong Jiang, Eric L. Brown, Heather T. Essigmann, Ashley S. Alexander, Andrew W. DuPont, Tehseen Iqbal, Netanya S. Utay, Michael Newmark, Mya C. Schiess
    Frontiers in Neurology.2023;[Epub]     CrossRef
  • Mesoporous silica nanoparticles: Their potential as drug delivery carriers and nanoscavengers in Alzheimer's and Parkinson's diseases
    Mohamed S. Attia, Ahmed Yahya, Nada Abdel Monaem, Shereen A. Sabry
    Saudi Pharmaceutical Journal.2023; 31(3): 417.     CrossRef
  • GSDMD in peripheral myeloid cells regulates microglial immune training and neuroinflammation in Parkinson's disease
    Bingwei Wang, Yan Ma, Sheng Li, Hang Yao, Mingna Gu, Ying Liu, You Xue, Jianhua Ding, Chunmei Ma, Shuo Yang, Gang Hu
    Acta Pharmaceutica Sinica B.2023;[Epub]     CrossRef
  • Gut-microbiome-brain axis: the crosstalk between the vagus nerve, alpha-synuclein and the brain in Parkinson’s disease
    Júlio César Claudino dos Santos, Leandro Freitas Oliveira, Felipe Micelli Noleto, Camilla Teixeira Pinheiro Gusmão, Gerly Anne de Castro Brito, Glauce Socorro de Barros Viana
    Neural Regeneration Research.2023; 18(12): 2611.     CrossRef
  • The intestinal luminal sources of α-synuclein: a gastroenterologist perspective
    Aaron Lerner
    Nutrition Reviews.2022; 80(2): 282.     CrossRef
  • Mild Chronic Colitis Triggers Parkinsonism in LRRK2 Mutant Mice Through Activating TNF ‐α Pathway
    Chin‐Hsien Lin, Han‐Yi Lin, En‐Pong Ho, Yi‐Ci Ke, Mei‐Fang Cheng, Chyng‐Yann Shiue, Chi‐Han Wu, Peng‐Hsiang Liao, Angela Yu‐Huey Hsu, Li‐An Chu, Ya‐Ding Liu, Ya‐Hui Lin, Yi‐Cheng Tai, Chia‐Tung Shun, Han‐Mo Chiu, Ming‐Shiang Wu
    Movement Disorders.2022; 37(4): 745.     CrossRef
  • Digesting recent findings: gut alpha-synuclein, microbiome changes in Parkinson’s disease
    Ehraz Anis, Aoji Xie, Lena Brundin, Patrik Brundin
    Trends in Endocrinology & Metabolism.2022; 33(2): 147.     CrossRef
  • Animal models of brain-first and body-first Parkinson's disease
    Nathalie Van Den Berge, Ayse Ulusoy
    Neurobiology of Disease.2022; 163: 105599.     CrossRef
  • Microbiome Changes in Humans with Parkinson’s Disease after Photobiomodulation Therapy: A Retrospective Study
    Brian Bicknell, Ann Liebert, Craig S. McLachlan, Hosen Kiat
    Journal of Personalized Medicine.2022; 12(1): 49.     CrossRef
  • Passive Immunization in Alpha-Synuclein Preclinical Animal Models
    Jonas Folke, Nelson Ferreira, Tomasz Brudek, Per Borghammer, Nathalie Van Den Berge
    Biomolecules.2022; 12(2): 168.     CrossRef
  • Dietary Succinoglycan Riclin Improves Glycemia Control in Mice with Type 2 Diabetes
    Zhao Ding, Yang Zhao, Junhao Liu, Wenhao Ge, Xi Xu, Shiming Wang, Jianfa Zhang
    Journal of Agricultural and Food Chemistry.2022; 70(6): 1819.     CrossRef
  • Role of Microbiota-Gut-Brain Axis in Regulating Dopaminergic Signaling
    Sevag Hamamah, Armin Aghazarian, Anthony Nazaryan, Andras Hajnal, Mihai Covasa
    Biomedicines.2022; 10(2): 436.     CrossRef
  • Distribution of α-Synuclein Aggregation in the Peripheral Tissues
    Yan-yan Li, Tian-tian Zhou, Yi Zhang, Nai-Hong Chen, Yu-He Yuan
    Neurochemical Research.2022; 47(12): 3627.     CrossRef
  • Effects of Subdiaphragmatic Vagotomy in the MPTP-induced Neurotoxicity in the Striatum and Colon of Mice
    Jiajing Shan, Youge Qu, Jiancheng Zhang, Li Ma, Kenji Hashimoto
    Clinical Psychopharmacology and Neuroscience.2022; 20(2): 389.     CrossRef
  • Alpha-Synuclein Strain Variability in Body-First and Brain-First Synucleinopathies
    Mie Kristine Just, Hjalte Gram, Vasileios Theologidis, Poul Henning Jensen, K. Peter R. Nilsson, Mikael Lindgren, Karoline Knudsen, Per Borghammer, Nathalie Van Den Berge
    Frontiers in Aging Neuroscience.2022;[Epub]     CrossRef
  • Urolithins: potential biomarkers of gut dysbiosis and disease stage in Parkinson's patients
    María Romo-Vaquero, Emiliano Fernández-Villalba, Ana-Luisa Gil-Martinez, Lorena Cuenca-Bermejo, Juan Carlos Espín, María Trinidad Herrero, María Victoria Selma
    Food & Function.2022; 13(11): 6306.     CrossRef
  • Short chain fatty acids-producing and mucin-degrading intestinal bacteria predict the progression of early Parkinson’s disease
    Hiroshi Nishiwaki, Mikako Ito, Tomonari Hamaguchi, Tetsuya Maeda, Kenichi Kashihara, Yoshio Tsuboi, Jun Ueyama, Takumi Yoshida, Hiroyuki Hanada, Ichiro Takeuchi, Masahisa Katsuno, Masaaki Hirayama, Kinji Ohno
    npj Parkinson's Disease.2022;[Epub]     CrossRef
  • Opicapone, a Novel Catechol-O-methyl Transferase Inhibitor, for Treatment of Parkinson’s Disease “Off” Episodes
    Amnon A. Berger, Ariel Winnick, Jonathan Izygon, Binil M. Jacob, Jessica S. Kaye, Rachel J. Kaye, Elisa E. Neuchat, Adam M. Kaye, Edward S. Alpaugh, Elyse M. Cornett, Andrew H. Han, Alan D. Kaye
    Health Psychology Research.2022;[Epub]     CrossRef
  • The role of LRRK2 in the periphery: link with Parkinson's disease and inflammatory diseases
    George Tsafaras, Veerle Baekelandt
    Neurobiology of Disease.2022; 172: 105806.     CrossRef
  • What Is the Prognostic Significance of Rapid Eye Movement Sleep Without Atonia in a Polysomnogram?
    Frank Ralls, Lisa Cutchen, Madeleine M. Grigg-Damberger
    Journal of Clinical Neurophysiology.2022; 39(5): 346.     CrossRef
  • Lippia grata essential oil complexed with β-cyclodextrin ameliorates biochemical and behavioral deficits in an animal model of progressive parkinsonism
    Jose Ivo A. Beserra-Filho, Amanda Maria-Macêdo, Suellen Silva-Martins, Ana Cláudia Custódio-Silva, Beatriz Soares-Silva, Sara Pereira Silva, Rafael Herling Lambertucci, Adriano Antunes de Souza Araújo, Angélica Maria Lucchese, Lucindo J. Quintans-Júnior,
    Metabolic Brain Disease.2022; 37(7): 2331.     CrossRef
  • Oral and gut dysbiosis leads to functional alterations in Parkinson’s disease
    Sungyang Jo, Woorim Kang, Yun Su Hwang, Seung Hyun Lee, Kye Won Park, Mi Sun Kim, Hyunna Lee, Hyung Jeong Yoon, Yoo Kyoung Park, Mauricio Chalita, Je Hee Lee, Hojun Sung, Jae-Yun Lee, Jin-Woo Bae, Sun Ju Chung
    npj Parkinson's Disease.2022;[Epub]     CrossRef
  • Deciphering Intertwined Molecular Pathways Underlying Metabolic Syndrome Leading to Parkinson’s Disease
    Ritu Soni, Jigna Shah
    ACS Chemical Neuroscience.2022; 13(15): 2240.     CrossRef
  • Therapeutic potential of short-chain fatty acid production by gut microbiota in neurodegenerative disorders
    Sarika Yadav, Ashish Dwivedi, Anurag Tripathi, Amit Kumar Tripathi
    Nutrition Research.2022; 106: 72.     CrossRef
  • Development of neurodegenerative disorders and the role of gut
    Woong-Woo Lee
    Journal of Geriatric Neurology.2022; 1(2): 53.     CrossRef
  • What Are the Key Gut Microbiota Involved in Neurological Diseases? A Systematic Review
    Bruno Bonnechère, Najaf Amin, Cornelia van Duijn
    International Journal of Molecular Sciences.2022; 23(22): 13665.     CrossRef
  • Brain modulation by the gut microbiota: From disease to therapy
    Sarmistha Mitra, Raju Dash, Amena Al Nishan, Sarmin Ummey Habiba, Il Soo Moon
    Journal of Advanced Research.2022;[Epub]     CrossRef
  • Gut microbiota in dementia with Lewy bodies
    Hiroshi Nishiwaki, Jun Ueyama, Kenichi Kashihara, Mikako Ito, Tomonari Hamaguchi, Tetsuya Maeda, Yoshio Tsuboi, Masahisa Katsuno, Masaaki Hirayama, Kinji Ohno
    npj Parkinson's Disease.2022;[Epub]     CrossRef
  • Gut dysbiosis in stroke and its implications on Alzheimer’s disease‐like cognitive dysfunction
    Justin Cho, You Jeong Park, Bella Gonzales‐Portillo, Madeline Saft, Blaise Cozene, Nadia Sadanandan, Cesar V. Borlongan
    CNS Neuroscience & Therapeutics.2021; 27(5): 505.     CrossRef
  • Plasma Lipopolysaccharide-Binding Protein Reflects Risk and Progression of Parkinson’s Disease
    Szu-Ju Chen, Yu-Chiao Chi, Chang-Han Ho, Wei-Shiung Yang, Chin-Hsien Lin
    Journal of Parkinson's Disease.2021; 11(3): 1129.     CrossRef
  • Parkinson's disease and the gut: Models of an emerging relationship
    Adam J. Bindas, Subhash Kulkarni, Ryan A. Koppes, Abigail N. Koppes
    Acta Biomaterialia.2021; 132: 325.     CrossRef
  • Ageing promotes pathological alpha-synuclein propagation and autonomic dysfunction in wild-type rats
    Nathalie Van Den Berge, Nelson Ferreira, Trine Werenberg Mikkelsen, Aage Kristian Olsen Alstrup, Gültekin Tamgüney, Páll Karlsson, Astrid Juhl Terkelsen, Jens Randel Nyengaard, Poul Henning Jensen, Per Borghammer
    Brain.2021; 144(6): 1853.     CrossRef
  • Desulfovibrio Bacteria Are Associated With Parkinson’s Disease
    Kari E. Murros, Vy A. Huynh, Timo M. Takala, Per E. J. Saris
    Frontiers in Cellular and Infection Microbiology.2021;[Epub]     CrossRef
  • “Janus-Faced” α-Synuclein: Role in Parkinson’s Disease
    Bipul Ray, Arehally M. Mahalakshmi, Sunanda Tuladhar, Abid Bhat, Asha Srinivasan, Christophe Pellegrino, Anbarasu Kannan, Srinivasa Rao Bolla, Saravana Babu Chidambaram, Meena Kishore Sakharkar
    Frontiers in Cell and Developmental Biology.2021;[Epub]     CrossRef
  • Influence of probiotic bacteria on gut microbiota composition and gut wall function in an in-vitro model in patients with Parkinson's disease
    Jonas Ghyselinck, Lynn Verstrepen, Frédéric Moens, Pieter Van Den Abbeele, Arnout Bruggeman, Jawal Said, Barry Smith, Lynne Ann Barker, Caroline Jordan, Valentina Leta, K. Ray Chaudhuri, Abdul W. Basit, Simon Gaisford
    International Journal of Pharmaceutics: X.2021; 3: 100087.     CrossRef
  • The Role of The Gut Microbiome in Parkinson’s Disease
    Amy Gallop, James Weagley, Saif-ur-Rahman Paracha, George Grossberg
    Journal of Geriatric Psychiatry and Neurology.2021; 34(4): 253.     CrossRef
  • The Baseline Structure of the Enteric Nervous System and Its Role in Parkinson’s Disease
    Gianfranco Natale, Larisa Ryskalin, Gabriele Morucci, Gloria Lazzeri, Alessandro Frati, Francesco Fornai
    Life.2021; 11(8): 732.     CrossRef
  • Regulation of neurotoxicity in the striatum and colon of MPTP-induced Parkinson’s disease mice by gut microbiome
    Jiajing Shan, Youge Qu, Siming Wang, Yan Wei, Lijia Chang, Li Ma, Kenji Hashimoto
    Brain Research Bulletin.2021; 177: 103.     CrossRef
  • Cholecystectomy and subsequent risk of Parkinson’s disease: a nationwide retrospective cohort study
    Ryul Kim, Jee-Young Lee, Sanghyun Park, Kyungdo Han, Cheol Min Shin
    npj Parkinson's Disease.2021;[Epub]     CrossRef
  • Benefits of Helicobacter pylori Eradication on Extragastric Diseases
    Tae Jun Kim, Hyuk Lee
    The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2021; 21(4): 275.     CrossRef
  • Higher cerebrospinal fluid to plasma ratio of p-cresol sulfate and indoxyl sulfate in patients with Parkinson’s disease
    Bartłomiej Sankowski, Karolina Księżarczyk, Emilia Raćkowska, Stanisław Szlufik, Dariusz Koziorowski, Joanna Giebułtowicz
    Clinica Chimica Acta.2020; 501: 165.     CrossRef
  • The microbiome-gut-brain axis in acute and chronic brain diseases
    Corinne Benakis, Camille Martin-Gallausiaux, Jean-Pierre Trezzi, Philip Melton, Arthur Liesz, Paul Wilmes
    Current Opinion in Neurobiology.2020; 61: 1.     CrossRef
  • The progress of gut microbiome research related to brain disorders
    Sibo Zhu, Yanfeng Jiang, Kelin Xu, Mei Cui, Weimin Ye, Genming Zhao, Li Jin, Xingdong Chen
    Journal of Neuroinflammation.2020;[Epub]     CrossRef
  • Minireview on the Relations between Gut Microflora and Parkinson’s Disease: Further Biochemical (Oxidative Stress), Inflammatory, and Neurological Particularities
    Ovidiu-Dumitru Ilie, Alin Ciobica, Jack McKenna, Bogdan Doroftei, Ioannis Mavroudis, Tuane B. Sampaio
    Oxidative Medicine and Cellular Longevity.2020; 2020: 1.     CrossRef
  • Microbiota-gut-brain axis in health and disease: Is NLRP3 inflammasome at the crossroads of microbiota-gut-brain communications?
    Carolina Pellegrini, Luca Antonioli, Vincenzo Calderone, Rocchina Colucci, Matteo Fornai, Corrado Blandizzi
    Progress in Neurobiology.2020; 191: 101806.     CrossRef
  • Meta‐Analysis of Gut Dysbiosis in Parkinson's Disease
    Hiroshi Nishiwaki, Mikako Ito, Tomohiro Ishida, Tomonari Hamaguchi, Tetsuya Maeda, Kenichi Kashihara, Yoshio Tsuboi, Jun Ueyama, Teppei Shimamura, Hiroshi Mori, Ken Kurokawa, Masahisa Katsuno, Masaaki Hirayama, Kinji Ohno
    Movement Disorders.2020; 35(9): 1626.     CrossRef
  • In Search of Effective Treatments Targeting α-Synuclein Toxicity in Synucleinopathies: Pros and Cons
    Maria Fouka, Panagiota Mavroeidi, Grigoria Tsaka, Maria Xilouri
    Frontiers in Cell and Developmental Biology.2020;[Epub]     CrossRef
  • Role of Carbon Monoxide in Host–Gut Microbiome Communication
    Christopher P. Hopper, Ladie Kimberly De La Cruz, Kristin V. Lyles, Lauren K. Wareham, Jack A. Gilbert, Zehava Eichenbaum, Marcin Magierowski, Robert K. Poole, Jakob Wollborn, Binghe Wang
    Chemical Reviews.2020; 120(24): 13273.     CrossRef
  • Neurodegeneration and Inflammation—An Interesting Interplay in Parkinson’s Disease
    Chrysoula Marogianni, Maria Sokratous, Efthimios Dardiotis, Georgios M. Hadjigeorgiou, Dimitrios Bogdanos, Georgia Xiromerisiou
    International Journal of Molecular Sciences.2020; 21(22): 8421.     CrossRef
  • Niacin and Butyrate: Nutraceuticals Targeting Dysbiosis and Intestinal Permeability in Parkinson’s Disease
    Tennekoon B. Karunaratne, Chijioke Okereke, Marissa Seamon, Sharad Purohit, Chandramohan Wakade, Amol Sharma
    Nutrients.2020; 13(1): 28.     CrossRef
  • Short-Chain Fatty Acid-Producing Gut Microbiota Is Decreased in Parkinson’s Disease but Not in Rapid-Eye-Movement Sleep Behavior Disorder
    Hiroshi Nishiwaki, Tomonari Hamaguchi, Mikako Ito, Tomohiro Ishida, Tetsuya Maeda, Kenichi Kashihara, Yoshio Tsuboi, Jun Ueyama, Teppei Shimamura, Hiroshi Mori, Ken Kurokawa, Masahisa Katsuno, Masaaki Hirayama, Kinji Ohno, Chaysavanh Manichanh
    mSystems.2020;[Epub]     CrossRef
  • The Intestinal Barrier in Parkinson’s Disease: Current State of Knowledge
    Sven C. D. van IJzendoorn, Pascal Derkinderen, Teus van Laar
    Journal of Parkinson's Disease.2019; 9(s2): S323.     CrossRef
  • Medical management, prevention and mitigation of environmental risks factors in Neurology
    J. Reis, G.C. Román, M. Giroud, V.S. Palmer, P.S. Spencer
    Revue Neurologique.2019; 175(10): 698.     CrossRef
  • Antibiotic-induced microbiome depletion protects against MPTP-induced dopaminergic neurotoxicity in the brain
    Yaoyu Pu, Lijia Chang, Youge Qu, Siming Wang, Kai Zhang, Kenji Hashimoto
    Aging.2019; 11(17): 6915.     CrossRef
Original Article
The Frequency and Severity of Gastrointestinal Symptoms in Patients with Early Parkinson’s Disease
Hye-Young Sung, Jeong-Wook Park, Joong-Seok Kim
J Mov Disord. 2014;7(1):7-12.   Published online April 30, 2014
DOI: https://doi.org/10.14802/jmd.14002
  • 16,993 View
  • 176 Download
  • 52 Citations
AbstractAbstract PDF
Objective: Although gastrointestinal dysfunctions occur in the majority of patients with Parkinson’s disease (PD), they are often unrecognized because many patients remain relatively asymptomatic in the early stage. We investigated the frequency of gastrointestinal symptoms in patients with PD using newly developed gastrointestinal symptom questionnaires.
Methods: Early PD patients with a symptom duration not exceeding 3 years were included in this study. All PD patients were evaluated using a questionnaire, which consisted of three relevant domains: oropharyngoesophageal (10 items); gastric (3 items); and intestinal-anorectal (7 items). The frequency of symptoms was calculated as a proportion with an item score ≥ 2.
Results: Of the 54 patients enrolled, 48 patients (88.9%) responded that bowel symptoms developed before the onset of Parkinsonian motor symptoms, and four patients reported that the onset of two types of symptoms (i.e., bowel and neurological) occurred approximately simultaneously, with only months between them. The frequencies of gastrointestinal symptoms are as follows: speech disturbance (40.7%), drooling (24.1%), sense of getting stuck (31.5%), choking (27.8%), globus pharyngis (16.7%), repetitive deglutition (29.6%), pain during swallowing (5.6%), food regurgitation (3.7%), acid reflux (7.4%), nausea/ vomiting (11.1%), early satiety (16.7%), postprandial fullness (14.8%), epigastric soreness (9.3%), abdominal pain (3.7%), constipation (46.3%), excessive strain during defecation (33.3%), fecal incontinence (7.4%), tenesmus (20.4%), loose stool or diarrhea (3.7%), and difficulty in relaxing anal sphincter (11.1%). Two patients were scored at zero.
Conclusions: Our findings confirm that gastrointestinal dysfunction occurs in early PD in relatively high frequency.

Citations

Citations to this article as recorded by  
  • Persistent intolerable abdominal pain in patients with Parkinson’s disease
    Hiroshi Kataoka, Kazuma Sugie
    Clinical Neurology and Neurosurgery.2023; 224: 107558.     CrossRef
  • Striatal Dopaminergic Loss and Dysphagia in Parkinson Disease
    Ji Hwan Kim, Jonghu Jeon, Young Lee, Seung Min Kim, Miju Cheon, Jun Yup Kim
    Clinical Nuclear Medicine.2023; 48(2): 143.     CrossRef
  • The gut microbiota is an emerging target for improving brain health during ageing
    Marcus Boehme, Katherine Elizabeth Guzzetta, Caroline Wasén, Laura Michelle Cox
    Gut Microbiome.2023;[Epub]     CrossRef
  • 6-OHDA-Induced Changes in Colonic Segment Contractility in the Rat Model of Parkinson’s Disease
    Maria Del Pilar Murillo, Ebba Johansson, Victoria Bryntesson, Patrik Aronsson, Gunnar Tobin, Michael Winder, Thomas Carlsson, Stephen Fink
    Gastroenterology Research and Practice.2023; 2023: 1.     CrossRef
  • Efficacy of acupuncture for the treatment of Parkinson’s disease-related constipation (PDC): A randomized controlled trial
    Ying-Jia Li, Ian-I Leong, Jing-Qi Fan, Ming-Yue Yan, Xin Liu, Wei-Jing Lu, Yuan-Yuan Chen, Wei-Qiang Tan, Yu-Ting Wang, Li-Xing Zhuang
    Frontiers in Neuroscience.2023;[Epub]     CrossRef
  • Considerations for developing a targeted amino acid supplement for people with Parkinson’s disease that promotes health while accounting for pathophysiology and medication interference
    Jacob E Earp, Cristina Colon-Semenza, Dara L LoBuono
    Nutrition Reviews.2023;[Epub]     CrossRef
  • Lactobacillus plantarum CCFM405 against Rotenone-Induced Parkinson’s Disease Mice via Regulating Gut Microbiota and Branched-Chain Amino Acids Biosynthesis
    Chuanqi Chu, Leilei Yu, Yiwen Li, Hang Guo, Qixiao Zhai, Wei Chen, Fengwei Tian
    Nutrients.2023; 15(7): 1737.     CrossRef
  • The longitudinal progression of autonomic dysfunction in Parkinson's disease: A 7-year study
    Charlotte B. Stewart, David Ledingham, Victoria K. Foster, Kirstie N. Anderson, Sahana Sathyanarayana, Debra Galley, Nicola Pavese, Jacopo Pasquini
    Frontiers in Neurology.2023;[Epub]     CrossRef
  • Association of dysphagia with altered brain glucose metabolism in Parkinson's disease
    Ji Yeon Oh, Eui Jin An, Young Lee, Seung Min Kim, Miju Cheon, Jun Yup Kim
    CNS Neuroscience & Therapeutics.2023;[Epub]     CrossRef
  • Differential Findings on Anorectal Manometry in Patients with Parkinson's Disease and Defecatory Dysfunction
    Wendy Zhou, George Triadafilopoulos, Brooke Gurland, Houssam Halawi, Laren Becker, Patricia Garcia, Linda Nguyen, Mitchell Miglis, Srikanth Muppidi, Dong‐In Sinn, Safwan Jaradeh, Leila Neshatian
    Movement Disorders Clinical Practice.2023;[Epub]     CrossRef
  • Related Effects of Methamphetamine on the Intestinal Barrier via Cytokines, and Potential Mechanisms by Which Methamphetamine May Occur on the Brain-Gut Axis
    Yuansen Li, Deshenyue Kong, Ke Bi, Huayou Luo
    Frontiers in Medicine.2022;[Epub]     CrossRef
  • Alpha-synuclein and tau are abundantly expressed in the ENS of the human appendix and monkey cecum
    Alexandra D. Zinnen, Jonathan Vichich, Jeanette M. Metzger, Julia C. Gambardella, Viktoriya Bondarenko, Heather A. Simmons, Marina E. Emborg, Stephan N. Witt
    PLOS ONE.2022; 17(6): e0269190.     CrossRef
  • Management of dysphagia and gastroparesis in Parkinson’s disease in real-world clinical practice – Balancing pharmacological and non-pharmacological approaches
    Roongroj Bhidayasiri, Warongporn Phuenpathom, Ai Huey Tan, Valentina Leta, Saisamorn Phumphid, K. Ray Chaudhuri, Pramod Kumar Pal
    Frontiers in Aging Neuroscience.2022;[Epub]     CrossRef
  • Mechanisms of development of constipation in Parkinson’s disease and therapeutic approaches
    E.A. Katunina, N.N. Shipilova, D.A. Katunin
    Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova.2022; 122(8): 21.     CrossRef
  • Intestinal Permeability, Dysbiosis, Inflammation and Enteric Glia Cells: The Intestinal Etiology of Parkinson’s Disease
    Huijia Yang, Song Li, Weidong Le
    Aging and disease.2022; 13(5): 1381.     CrossRef
  • The interplay between the gut-brain axis and the microbiome: A perspective on psychiatric and neurodegenerative disorders
    Yasir Bashir, Asad U. Khan
    Frontiers in Neuroscience.2022;[Epub]     CrossRef
  • Clinical features and relative factors of constipation in a cohort of Chinese patients with Parkinson's disease
    Bai-Hua Sun, Tao Wang, Nian-Ying Li, Qiong Wu, Jin Qiao
    World Journal of Gastrointestinal Pharmacology and Therapeutics.2021; 12(1): 21.     CrossRef
  • Characterization of Gastrointestinal Symptom Type and Severity in Parkinson's Disease: A Case–Control Study in an Australian Cohort
    Jade E. Kenna, Megan C. Bakeberg, Anastazja M. Gorecki, Alfred Chin Yen Tay, Samantha Winter, Frank L. Mastaglia, Ryan S. Anderton
    Movement Disorders Clinical Practice.2021; 8(2): 245.     CrossRef
  • Granisetron, a selective 5-HT3 antagonist, reduces L-3,4-dihydroxyphenylalanine-induced abnormal involuntary movements in the 6-hydroxydopamine-lesioned rat
    Cynthia Kwan, Imane Frouni, Dominique Bédard, Adjia Hamadjida, Philippe Huot
    Behavioural Pharmacology.2021; 32(1): 43.     CrossRef
  • Deglutition Impairment during Dual Task in Parkinson Disease Is Associated with Cognitive Status
    Luciana Grolli Ardenghi, Alana Verza Signorini, Gerson Schulz Maahs, Fabio Selaimen, Konrado Massing Deutsch, Silvia Dornelles, Carlos Roberto de Mello Rieder
    International Archives of Otorhinolaryngology.2021; 25(01): e41.     CrossRef
  • Spectrum of Non-Motor Symptoms in Parkinson's Disease
    Maithrayie Kumaresan, Safeera Khan
    Cureus.2021;[Epub]     CrossRef
  • Onset of Skin, Gut, and Genitourinary Prodromal Parkinson's Disease: A Study of 1.5 Million Veterans
    Gregory D. Scott, Miranda M. Lim, Matthew G. Drake, Randy Woltjer, Joseph F. Quinn
    Movement Disorders.2021; 36(9): 2094.     CrossRef
  • The Gastrointestinal Dysfunction Scale for Parkinson's Disease
    Marta Camacho, Julia C. Greenland, Caroline H. Williams‐Gray
    Movement Disorders.2021; 36(10): 2358.     CrossRef
  • The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders
    Katarzyna Socała, Urszula Doboszewska, Aleksandra Szopa, Anna Serefko, Marcin Włodarczyk, Anna Zielińska, Ewa Poleszak, Jakub Fichna, Piotr Wlaź
    Pharmacological Research.2021; 172: 105840.     CrossRef
  • Neuro-Immunity and Gut Dysbiosis Drive Parkinson’s Disease-Induced Pain
    Katiane Roversi, Natalia Callai-Silva, Karine Roversi, May Griffith, Christos Boutopoulos, Rui Daniel Prediger, Sébastien Talbot
    Frontiers in Immunology.2021;[Epub]     CrossRef
  • Autonomic dysfunction in Parkinson’s disease: Implications for pathophysiology, diagnosis, and treatment
    Zhichun Chen, Guanglu Li, Jun Liu
    Neurobiology of Disease.2020; 134: 104700.     CrossRef
  • Double‐Blind , Randomized, Placebo‐Controlled Trial of DA ‐9701 in Parkinson's Disease: PASS ‐ GI Study
    Ji‐Hyun Choi, Jee‐Young Lee, Jin Whan Cho, Seong‐Beom Koh, Young Soon Yang, Dalla Yoo, Cheol‐Min Shin, Hee Tae Kim
    Movement Disorders.2020; 35(11): 1966.     CrossRef
  • Parkinson disease and the gut: new insights into pathogenesis and clinical relevance
    R. Alberto Travagli, Kirsteen N. Browning, Michael Camilleri
    Nature Reviews Gastroenterology & Hepatology.2020; 17(11): 673.     CrossRef
  • Expanding the brain researcher's toolkit
    Viviana Gradinaru
    Science.2020; 369(6504): 637.     CrossRef
  • Excessive buccal saliva in patients with Parkinson’s disease of the French COPARK cohort
    Olivier Rascol, Laurence Negre-Pages, Philippe Damier, Arnaud Delval, Pascal Derkinderen, Alain Destée, Margherita Fabbri, Wassilios G. Meissner, Amine Rachdi, François Tison, Santiago Perez-Lloret
    Journal of Neural Transmission.2020; 127(12): 1607.     CrossRef
  • Struktur und Efferenzen der Substantia nigra pars compacta beim idiopathischen Parkinson-Syndrom
    Peter Urban, Bjorn Falkenburger, Wolfgang H. Jost, Gerhard Ransmayr, Peter Riederer, Christian Winkler
    Fortschritte der Neurologie · Psychiatrie.2020; 88(09): 591.     CrossRef
  • Parkinson’s disease: Are gut microbes involved?
    Yogesh Bhattarai, Purna C. Kashyap
    American Journal of Physiology-Gastrointestinal and Liver Physiology.2020; 319(5): G529.     CrossRef
  • Does Bilateral Deep Brain Stimulation of the Subthalamic Nucleus Modify Ano-Rectal Motility in Parkinson’s Disease? Results of a Randomized Cross-Over Study
    Guillaume Gourcerol, David Maltete, Nathalie Chastan, Marie Laure Welter, Anne Marie Leroi, Stéphane Derrey
    Neuromodulation: Technology at the Neural Interface.2019; 22(4): 478.     CrossRef
  • Probiotics for Parkinson’s Disease
    Gazerani
    International Journal of Molecular Sciences.2019; 20(17): 4121.     CrossRef
  • Colon dysregulation in methamphetamine self-administering HIV-1 transgenic rats
    Amanda L. Persons, Brinda D. Bradaric, Hemraj B. Dodiya, Michael Ohene-Nyako, Christopher B. Forsyth, Ali Keshavarzian, Maliha Shaikh, T. Celeste Napier, Shilpa J. Buch
    PLOS ONE.2018; 13(1): e0190078.     CrossRef
  • Induction of alpha-synuclein pathology in the enteric nervous system of the rat and non-human primate results in gastrointestinal dysmotility and transient CNS pathology
    Fredric P. Manfredsson, Kelvin C. Luk, Matthew J. Benskey, Aysegul Gezer, Joanna Garcia, Nathan C. Kuhn, Ivette M. Sandoval, Joseph R. Patterson, Alana O'Mara, Reid Yonkers, Jeffrey H. Kordower
    Neurobiology of Disease.2018; 112: 106.     CrossRef
  • Dysbiosis of gut microbiota and microbial metabolites in Parkinson’s Disease
    Meng-Fei Sun, Yan-Qin Shen
    Ageing Research Reviews.2018; 45: 53.     CrossRef
  • Parkinson’s Disease and Current Treatments for Its Gastrointestinal Neurogastromotility Effects
    Chethan Ramprasad, Jane Yellowlees Douglas, Baharak Moshiree
    Current Treatment Options in Gastroenterology.2018; 16(4): 489.     CrossRef
  • Transdermal rotigotine patch in Parkinson’s disease with a history of intestinal operation
    Takashi Ogawa, Genko Oyama, Nobutaka Hattori
    BMJ Case Reports.2018; : bcr-2017-223722.     CrossRef
  • α-Synuclein in the colon and premotor markers of Parkinson disease in neurologically normal subjects
    Joong-Seok Kim, In-Seok Park, Hyung-Eun Park, Su-Young Kim, Jung A Yun, Chan Kwon Jung, Hye-Young Sung, Jin-Kwon Lee, Won-Kyung Kang
    Neurological Sciences.2017; 38(1): 171.     CrossRef
  • The Threshold Theory for Parkinson's Disease
    Simone Engelender, Ole Isacson
    Trends in Neurosciences.2017; 40(1): 4.     CrossRef
  • Constipation in parkinson's disease: Subjective symptoms, objective markers, and new perspectives
    Karoline Knudsen, Klaus Krogh, Karen Østergaard, Per Borghammer
    Movement Disorders.2017; 32(1): 94.     CrossRef
  • Is Levodopa Pharmacokinetics in Patients with Parkinson’s Disease Depending on Gastric Emptying?
    Maria Nord, Anita Kullman, Ulf Hannestad, Nil Dizdar
    Advances in Parkinson's Disease.2017; 06(01): 1.     CrossRef
  • Validation of the Korean Version of the Scale for Outcomes in Parkinson’s Disease-Autonomic
    Ji-Young Kim, In-Uk Song, Seong-Beom Koh, Tae-Beom Ahn, Sang Jin Kim, Sang-Myung Cheon, Jin Whan Cho, Yun Joong Kim, Hyeo-Il Ma, Mee-Young Park, Jong Sam Baik, Phil Hyu Lee, Sun Ju Chung, Jong-Min Kim, Han-Joon Kim, Young-Hee Sung, Do Young Kwon, Jae-Hyeo
    Journal of Movement Disorders.2017; 10(1): 29.     CrossRef
  • Gastroesophageal reflux disease with proton pump inhibitor use is associated with an increased risk of osteoporosis: a nationwide population-based analysis
    C.-H. Chen, C.-L. Lin, C.-H. Kao
    Osteoporosis International.2016; 27(6): 2117.     CrossRef
  • Parkinson Disease-Mediated Gastrointestinal Disorders and Rational for Combinatorial Therapies
    Syed Ali, Ning Yin, Arkam Rehman, Verline Justilien
    Medical Sciences.2016; 4(1): 1.     CrossRef
  • Intestinal dysfunction in Parkinson's disease: Lessons learned from translational studies and experimental models
    C. Pellegrini, R. Colucci, L. Antonioli, E. Barocelli, V. Ballabeni, N. Bernardini, C. Blandizzi, W. J. de Jonge, M. Fornai
    Neurogastroenterology & Motility.2016; 28(12): 1781.     CrossRef
  • Gut dysfunction in Parkinson's disease
    Adreesh Mukherjee, Atanu Biswas, Shyamal Kumar Das
    World Journal of Gastroenterology.2016; 22(25): 5742.     CrossRef
  • Inflammation is genetically implicated in Parkinson’s disease
    N. Dzamko, C.L Geczy, G.M Halliday
    Neuroscience.2015; 302: 89.     CrossRef
  • Alteration of enteric monoamines with monoamine receptors and colonic dysmotility in 6-OHDA-induced Parkinson’s disease rats
    Xiaoli Zhang, Yun Li, Chenzhe Liu, Ruifang Fan, Ping Wang, Lifei Zheng, Feng Hong, Xiaoyan Feng, Yue Zhang, Lisheng Li, Jinxia Zhu
    Translational Research.2015;[Epub]     CrossRef
  • The treatment of gastroparesis, constipation and small intestinal bacterial overgrowth syndrome in patients with Parkinson’s disease
    Jose L Barboza, Michael S Okun, Baharak Moshiree
    Expert Opinion on Pharmacotherapy.2015; 16(16): 2449.     CrossRef
  • Gastrointestinal Dysfunctions in Parkinson’s Disease
    Joong-Seok Kim, Hey Young Sung
    Journal of the Korean Neurological Association.2015; 33(4): 247.     CrossRef
Review Articles
Episodic Ataxias: Clinical and Genetic Features
Kwang-Dong Choi, Jae-Hwan Choi
J Mov Disord. 2016;9(3):129-135.   Published online September 21, 2016
DOI: https://doi.org/10.14802/jmd.16028
  • 21,550 View
  • 824 Download
  • 51 Citations
AbstractAbstract PDF
Episodic ataxia (EA) is a clinically heterogeneous group of disorders that are characterized by recurrent spells of truncal ataxia and incoordination lasting minutes to hours. Most have an autosomal dominant inheritance pattern. To date, 8 subtypes have been defined according to clinical and genetic characteristics, and five genes are known to be linked to EAs. Both EA1 and EA2, which are caused by mutations in KCNA1 and CACNA1A, account for the majority of EA, but many patients with no identified mutations still exhibit EA-like clinical features. Furthermore, genetically confirmed EAs have mostly been identified in Caucasian families. In this article, we review the current knowledge on the clinical and genetic characteristics of EAs. Additionally, we summarize the phenotypic features of the genetically confirmed EA2 families in Korea.

Citations

Citations to this article as recorded by  
  • Ataxien – Eine aktuelle Übersicht über die weiter wachsende Anzahl möglicher Diagnosen
    Andreas Thieme, Dagmar Timmann
    Neuroradiologie Scan.2023; 13(01): 63.     CrossRef
  • Zerebellärer Schwindel, was steckt dahinter?
    Katharina Feil, Tim W. Rattay, Adedolapo Kamaldeen Adeyemi, Nicolina Goldschagg, Michael Strupp
    Nervenheilkunde.2023; 42(01/02): 37.     CrossRef
  • Ataxias: Hereditary, Acquired, and Reversible Etiologies
    Chi-Ying R. Lin, Sheng-Han Kuo
    Seminars in Neurology.2023; 43(01): 048.     CrossRef
  • SCN2A- Associated Episodic and Persistent Ataxia with Cerebellar Atrophy: A Case Report
    Maeve Murray, Jaclyn M. Martindale, Scott I. Otallah
    Child Neurology Open.2023; 10: 2329048X2311639.     CrossRef
  • Episodic Ataxias: Primary and Secondary Etiologies, Treatment, and Classification Approaches
    Anhar Hassan
    Tremor and Other Hyperkinetic Movements.2023;[Epub]     CrossRef
  • Novel Genetic Variants Expand the Functional, Molecular, and Pathological Diversity of KCNA1 Channelopathy
    Kelsey Paulhus, Edward Glasscock
    International Journal of Molecular Sciences.2023; 24(10): 8826.     CrossRef
  • Coincidental occurance of episodic ataxia and multiple sclerosis: a case report and review of the literature
    Melike Batum, Ayşın Kısabay Ak, Güldeniz Çetin, Hamide Betül Gerik Çelebi, Sırrı Çam, Hatice Mavioğlu
    International Journal of Neuroscience.2022; 132(7): 656.     CrossRef
  • Vestibular impairments in episodic ataxia type 2
    Jae-Hwan Choi, Eun Hye Oh, Seo Young Choi, Hyo Jung Kim, Seon Kyung Lee, Jeong Yoon Choi, Ji-Soo Kim, Kwang-Dong Choi
    Journal of Neurology.2022; 269(5): 2687.     CrossRef
  • History of Ataxias and Paraplegias with an Annotation on the First Description of Striatonigral Degeneration
    José Berciano, José Gazulla, Jon Infante
    The Cerebellum.2022; 21(4): 531.     CrossRef
  • The complexities of CACNA1A in clinical neurogenetics
    Marina P. Hommersom, Teije H. van Prooije, Maartje Pennings, Meyke I. Schouten, Hans van Bokhoven, Erik-Jan Kamsteeg, Bart P. C. van de Warrenburg
    Journal of Neurology.2022; 269(6): 3094.     CrossRef
  • Genetic paroxysmal neurological disorders featuring episodic ataxia and epilepsy
    Elisabetta Amadori, Giuditta Pellino, Lalit Bansal, Serena Mazzone, Rikke S. Møller, Guido Rubboli, Pasquale Striano, Angelo Russo
    European Journal of Medical Genetics.2022; 65(4): 104450.     CrossRef
  • Ataxien – Eine aktuelle Übersicht über die weiter wachsende Anzahl möglicher Diagnosen
    Andreas Thieme, Dagmar Timmann
    Fortschritte der Neurologie · Psychiatrie.2022; 90(05): 233.     CrossRef
  • Episodic ataxias in children and adolescents: Clinical findings and suggested diagnostic criteria
    Filipp Maximilian Filippopulos, Lutz Schnabel, Konstanze Dunker, Ralf Strobl, Doreen Huppert
    Frontiers in Neurology.2022;[Epub]     CrossRef
  • Vertical Saccadic Slowing in Episodic Ataxia Type 2
    Seoyeon Kim, Seondeuk Kim, Seonkyung Lee, Hyo-Jung Kim
    Journal of Clinical Neurology.2022; 18(6): 726.     CrossRef
  • Episodic Vestibular Syndrome with Hyperventilation-Induced Downbeat Nystagmus
    Eun Hye Oh, Jin-Hong Shin, Jae Wook Cho, Seo Young Choi, Kwang-Dong Choi, Je-Keun Rhee, Jae-Hwan Choi
    The Cerebellum.2021; 20(5): 796.     CrossRef
  • Functional and Biochemical Consequences of Disease Variants in Neurotransmitter Transporters: A Special Emphasis on Folding and Trafficking Deficits
    Shreyas Bhat, Ali El-Kasaby, Michael Freissmuth, Sonja Sucic
    Pharmacology & Therapeutics.2021; 222: 107785.     CrossRef
  • Therapeutic roles of natural remedies in combating hereditary ataxia: A systematic review
    Michael Weng Lok Phang, Sze Yuen Lew, Ivy Chung, William Kiong-Seng Lim, Lee Wei Lim, Kah Hui Wong
    Chinese Medicine.2021;[Epub]     CrossRef
  • Episodic psychosis, ataxia, motor neuropathy with pyramidal signs (PAMP syndrome) caused by a novel mutation in ADPRHL2 (AHR3)
    Hacer Durmus, Elif Mertoğlu, Heinrich Sticht, Serdar Ceylaner, Işın Baral Kulaksızoğlu, Said Hashemolhosseini, Evren Önay Uçar, Yesim Parman
    Neurological Sciences.2021; 42(9): 3871.     CrossRef
  • Pediatric Paroxysmal Exercise-Induced Neurological Symptoms: Clinical Spectrum and Diagnostic Algorithm
    Federica Rachele Danti, Federica Invernizzi, Isabella Moroni, Barbara Garavaglia, Nardo Nardocci, Giovanna Zorzi
    Frontiers in Neurology.2021;[Epub]     CrossRef
  • Paroxysmal Movement Disorders
    Susan Harvey, Mary D. King, Kathleen M. Gorman
    Frontiers in Neurology.2021;[Epub]     CrossRef
  • Downbeat nystagmus: a clinical review of diagnosis and management
    Tu M. Tran, Michael S. Lee, Collin M. McClelland
    Current Opinion in Ophthalmology.2021; 32(6): 504.     CrossRef
  • Ataxien – Eine aktuelle Übersicht über die weiter wachsende Anzahl möglicher Diagnosen
    Andreas Thieme, Dagmar Timmann
    Neurologie up2date.2021; 04(04): 391.     CrossRef
  • Ataxia episódica: 20 años de retraso diagnóstico
    I. Muro García, M.E. Toribio-Díaz, S. Quintas
    Neurología.2020; 35(7): 500.     CrossRef
  • The expanding spectrum of movement disorders in genetic epilepsies
    Apostolos Papandreou, Federica Rachele Danti, Robert Spaull, Vincenzo Leuzzi, Amy Mctague, Manju A Kurian
    Developmental Medicine & Child Neurology.2020; 62(2): 178.     CrossRef
  • Episodic Ataxia Secondary to CEP290 Compound Heterozygous Mutations: A Case Report
    Moath Hamed, Aakash Shetty, Tara Dzwiniel, Mark Buller, Lotta Koskinen, Oksana Suchowersky
    Movement Disorders Clinical Practice.2020; 7(1): 104.     CrossRef
  • Movement Disorders in Genetic Pediatric Ataxias
    Simone Gana, Enza Maria Valente
    Movement Disorders Clinical Practice.2020; 7(4): 383.     CrossRef
  • Clinical Spectrum of KCNA1 Mutations: New Insights into Episodic Ataxia and Epilepsy Comorbidity
    Kelsey Paulhus, Lauren Ammerman, Edward Glasscock
    International Journal of Molecular Sciences.2020; 21(8): 2802.     CrossRef
  • Approach to exaggerated startle reflex: a case of hyperekplexia minor
    Haris Hakeem, Ramsha Khurshid, Fowzia Siddiqui, Danish Ejaz Bhatti
    BMJ Case Reports.2020; 13(4): e232370.     CrossRef
  • Clinical and Genetic Overview of Paroxysmal Movement Disorders and Episodic Ataxias
    Giacomo Garone, Alessandro Capuano, Lorena Travaglini, Federica Graziola, Fabrizia Stregapede, Ginevra Zanni, Federico Vigevano, Enrico Bertini, Francesco Nicita
    International Journal of Molecular Sciences.2020; 21(10): 3603.     CrossRef
  • Drosophila Glia: Models for Human Neurodevelopmental and Neurodegenerative Disorders
    Taejoon Kim, Bokyeong Song, Im-Soon Lee
    International Journal of Molecular Sciences.2020; 21(14): 4859.     CrossRef
  • The Genetic Relationship between Paroxysmal Movement Disorders and Epilepsy
    Hyunji Ahn, Tae-Sung Ko
    Annals of Child Neurology.2020; 28(3): 76.     CrossRef
  • Episodic ataxia: a 20-year diagnostic delay
    I. Muro García, M.E. Toribio-Díaz, S. Quintas
    Neurología (English Edition).2020; 35(7): 500.     CrossRef
  • TRPM7 as a Candidate Gene for Vestibular Migraine
    Eun Hye Oh, Jin-Hong Shin, Jae Wook Cho, Seo-Young Choi, Kwang-Dong Choi, Jae-Hwan Choi
    Frontiers in Neurology.2020;[Epub]     CrossRef
  • Ictal downbeat nystagmus in Ménière disease
    Sun-Uk Lee, Hyo-Jung Kim, Jeong-Yoon Choi, Ji-Soo Kim
    Neurology.2020; 95(17): e2409.     CrossRef
  • Involvement of the Peripheral Nervous System in Episodic Ataxias
    Wojciech Koźmiński, Joanna Pera
    Biomedicines.2020; 8(11): 448.     CrossRef
  • Acetazolamide-Responsive Episodic Ataxia Linked to Novel Splice Site Variant in FGF14 Gene
    M. Schesny, F. Joncourt, Alexander A. Tarnutzer
    The Cerebellum.2019; 18(3): 649.     CrossRef
  • Paroxysmal movement disorders: Recent advances and proposal of a classification system
    Xiao-jin Zhang, Zhe-yu Xu, Yun-cheng Wu, Eng-King Tan
    Parkinsonism & Related Disorders.2019; 59: 131.     CrossRef
  • Acute cerebellar ataxia: differential diagnosis and clinical approach
    José Luiz Pedroso, Thiago Cardoso Vale, Pedro Braga-Neto, Lívia Almeida Dutra, Marcondes Cavalcante França Jr, Hélio A. G. Teive, Orlando G. P. Barsottini
    Arquivos de Neuro-Psiquiatria.2019; 77(3): 184.     CrossRef
  • Acute vestibular asymmetry disorder: a new disease entity in acute vestibular syndrome?
    Se A. Lee, Eek-Sung Lee, Bo Gyung Kim, Tae-Kyeong Lee, Ki-Bum Sung, Kyurin Hwang, Jong Dae Lee
    Acta Oto-Laryngologica.2019; 139(6): 511.     CrossRef
  • Paroxysmal Movement Disorders: Recent Advances
    Zheyu Xu, Che-Kang Lim, Louis C. S. Tan, Eng-King Tan
    Current Neurology and Neuroscience Reports.2019;[Epub]     CrossRef
  • Paroxysmal movement disorders – practical update on diagnosis and management
    Claudio M. De Gusmao, Laura Silveira-Moriyama
    Expert Review of Neurotherapeutics.2019; 19(9): 807.     CrossRef
  • Clinical manifestations of episodic ataxia type 5
    Miguel González Sánchez, Silvia Izquierdo, Sara Álvarez, Rosa Eva Bautista Alonso, José Berciano, José Gazulla
    Neurology: Clinical Practice.2019; 9(6): 503.     CrossRef
  • Pearls & Oy-sters: Paroxysmal dysarthria-ataxia syndrome
    Annalisa Gessani, Francesco Cavallieri, Carla Budriesi, Elisabetta Zucchi, Marcella Malagoli, Sara Contardi, Maria Teresa Mascia, Giada Giovannini, Jessica Mandrioli
    Neurology.2019; 92(23): e2727.     CrossRef
  • Consensus Paper: Neurophysiological Assessments of Ataxias in Daily Practice
    W. Ilg, M. Branscheidt, A. Butala, P. Celnik, L. de Paola, F. B. Horak, L. Schöls, H. A. G. Teive, A. P. Vogel, D. S. Zee, D. Timmann
    The Cerebellum.2018; 17(5): 628.     CrossRef
  • The expanding spectrum of paroxysmal movement disorders: update from clinical features to therapeutics
    Eavan M. McGovern, Emmanuel Roze, Timothy J. Counihan
    Current Opinion in Neurology.2018; 31(4): 491.     CrossRef
  • Benign paroxysmal torticollis of infancy does not lead to neurological sequelae
    Annika Danielsson, Britt-Marie Anderlid, Tommy Stödberg, Kristina Lagerstedt-Robinson, Eva Klackenberg Arrhenius, Kristina Tedroff
    Developmental Medicine & Child Neurology.2018; 60(12): 1251.     CrossRef
  • Epidemiology of inherited cerebellar ataxias and challenges in clinical research
    Federica Pilotto, Smita Saxena
    Clinical and Translational Neuroscience.2018; 2(2): 2514183X1878525.     CrossRef
  • Ataxia in children: early recognition and clinical evaluation
    Piero Pavone, Andrea D. Praticò, Vito Pavone, Riccardo Lubrano, Raffaele Falsaperla, Renata Rizzo, Martino Ruggieri
    Italian Journal of Pediatrics.2017;[Epub]     CrossRef
  • Episodic Ataxia Type 1 (K-channelopathy) Manifesting as Paroxysmal Nonkinesogenic Dyskinesia: Expanding the Phenotype
    Kallol K. Set, Debabrata Ghosh, A.H.M. Huq, Aimee F. Luat
    Movement Disorders Clinical Practice.2017; 4(5): 784.     CrossRef
  • Genetic Variants Associated with Episodic Ataxia in Korea
    Kwang-Dong Choi, Ji-Soo Kim, Hyo-Jung Kim, Ileok Jung, Seong-Hae Jeong, Seung-Han Lee, Dong Uk Kim, Sang-Ho Kim, Seo Young Choi, Jin-Hong Shin, Dae-Seong Kim, Kyung-Pil Park, Hyang-Sook Kim, Jae-Hwan Choi
    Scientific Reports.2017;[Epub]     CrossRef
  • Episodic dizziness and vertigo
    Štefan Sivák
    Neurologie pro praxi.2017; 18(3): 156.     CrossRef
COVID-19: An Early Review of Its Global Impact and Considerations for Parkinson’s Disease Patient Care
Roongroj Bhidayasiri, Sasivimol Virameteekul, Jong-Min Kim, Pramod Kr. Pal, Sun-Ju Chung
J Mov Disord. 2020;13(2):105-114.   Published online April 30, 2020
DOI: https://doi.org/10.14802/jmd.20042
  • 18,508 View
  • 751 Download
  • 46 Citations
AbstractAbstract PDF
While many infectious disorders are unknown to most neurologists, COVID-19 is very different. It has impacted neurologists and other health care workers, not only in our professional lives but also through the fear and panic within our own families, colleagues, patients and their families, and even in the wider public. COVID-19 affects all sorts of individuals, but the elderly with underlying chronic conditions are particularly at risk of severe disease, or even death. Parkinson’s disease (PD) shares a common profile as an age-dependent degenerative disorder, frequently associated with comorbidities, particularly cardiovascular diseases, so PD patients will almost certainly fall into the high-risk group. Therefore, the aim of this review is to explore the risk of COVID-19 in PD based on the susceptibility to severe disease, its impact on PD disease severity, potential long-term sequelae, and difficulties of PD management during this outbreak, where neurologists face various challenges on how we can maintain effective care for PD patients without exposing them, or ourselves, to the risk of infection. It is less than six months since the identification of the original COVID-19 case on New Year’s Eve 2019, so it is still too early to fully understand the natural history of COVID-19 and the evidence on COVID-19-related PD is scant. Though the possibilities presented are speculative, they are theory-based, and supported by prior evidence from other neurotrophic viruses closely related to SARS-CoV-2. Neurologists should be on high alert and vigilant for potential acute and chronic complications when encountering PD patients who are suspected of having COVID-19.

Citations

Citations to this article as recorded by  
  • Survey on the Impact of the COVID-19 Pandemic on Patients with Parkinson’s Disease and Their Caregivers in Japan
    Nobutaka Hattori, Yoshiko Okada, Yayoi Kawata, Yoshihiko Furusawa, Takumi Imai, Hisako Yoshida, Mihoko Ota, Masaki Arai, Ayumi Shintani, Jovelle Fernandez
    Patient Preference and Adherence.2023; Volume 17: 1221.     CrossRef
  • COVID-19 and neurological disorders: what might connect Parkinson’s disease to SARS-CoV-2 infection
    Salvatore Iacono, Giuseppe Schirò, Chiara Davì, Sergio Mastrilli, Michelle Abbott, Fabrizio Guajana, Valentina Arnao, Paolo Aridon, Paolo Ragonese, Cesare Gagliardo, Claudia Colomba, Nicola Scichilone, Marco D’Amelio
    Frontiers in Neurology.2023;[Epub]     CrossRef
  • Doctor Hope; Calming and Comforting Loneliness in Parkinson’s Disease
    Sasivimol Virameteekul, Roongroj Bhidayasiri
    Clinical Parkinsonism & Related Disorders.2022; 6: 100131.     CrossRef
  • Neurological toll of COVID-19
    Shivam Bhola, Jhillika Trisal, Vikram Thakur, Parneet Kaur, Saurabh Kulshrestha, Shashi Kant Bhatia, Pradeep Kumar
    Neurological Sciences.2022; 43(4): 2171.     CrossRef
  • Resilience and Trauma among Patients with Parkinson’s Disease during the COVID-19 Pandemic
    Roberto Erro, Sofia Cuoco, Emanuele Nigro, Raffaele Ragone, Paolo Barone
    Journal of Movement Disorders.2022; 15(1): 77.     CrossRef
  • Implication of Covid-19 on Neurological Complications with Specific Emphasis on Alzheimer’s and Parkinson’s Disease
    Ankita Sood, Ravi Goyal, Harshdeep Singh, Tapan Behl, Sandeep Arora, Balraj Saini, Rajwinder Kaur
    CNS & Neurological Disorders - Drug Targets.2022; 21(3): 235.     CrossRef
  • The use of amantadine in the prevention of progression and treatment of COVID-19 symptoms in patients infected with the SARS-CoV-2 virus (COV-PREVENT): Study rationale and design
    Konrad Rejdak, Piotr Fiedor, Robert Bonek, Aleksander Goch, Agnieszka Gala-Błądzińska, Waldemar Chełstowski, Jacek Łukasiak, Sławomir Kiciak, Piotr Dąbrowski, Mateusz Dec, Zbigniew J. Król, Ewa Papuć, Adriana Zasybska, Agnieszka Segiet, Paweł Grieb
    Contemporary Clinical Trials.2022; 116: 106755.     CrossRef
  • Neuropathological Aspects of SARS-CoV-2 Infection: Significance for Both Alzheimer’s and Parkinson’s Disease
    Jaime Silva, Felipe Patricio, Aleidy Patricio-Martínez, Gerardo Santos-López, Lilia Cedillo, Yousef Tizabi, Ilhuicamina Daniel Limón
    Frontiers in Neuroscience.2022;[Epub]     CrossRef
  • Online dance classes during the Covid-19 pandemic: new challenges and teaching strategies for the ‘Dance & Parkinson’s at home’ project
    Marcela Dos Santos Delabary, Isadora Loch Sbeghen, Mariana Wolffenbuttel, Djefri Ramon Pereira, Aline Nogueira Haas
    Research in Dance Education.2022; : 1.     CrossRef
  • Impact of the COVID-19 Pandemic on Chronic Neurological Disorders: Focus on Patients with Dementia
    Maria Antonietta Barbieri, Gianluca Bagnato, Carmelo Ioppolo, Antonio Giovanni Versace, Natasha Irrera
    CNS & Neurological Disorders - Drug Targets.2022; 21(10): 1017.     CrossRef
  • COVID-19 and Parkinson’s disease: a systematic review and meta-analysis
    Maryam Afraie, Ghobad Moradi, Pardis Mohammadzedeh, Mobin Azami, Sevda Riyahifar, Yousef Moradi
    Acta Neurologica Belgica.2022;[Epub]     CrossRef
  • Factors Related to Experiencing Pain in Patients Affected by Chronic Inflammatory Rheumatic Disease During the COVID-19 Pandemic
    Tfarah El Joumani, Hanan Rkain, Fatima Zahrae Taik, Kenza Hassouni, Redouane Abouqal, Sara Bahloul, Nada Alami, Latifa Tahiri, Najia Hajjaj-Hassouni, Fadoua Allali
    The Open Pain Journal.2022;[Epub]     CrossRef
  • A “new” role of amantadines in COVID-19 in patients with Parkinson’s disease: results of own comparative study
    Z. A. Zalyalova, S. E. Munasipova, D. M. Khasanova, G. R. Ilyina, Z. G. Khayatova, N. I. Bagdanova
    Neurology, Neuropsychiatry, Psychosomatics.2022; 14(6): 40.     CrossRef
  • Attitudes toward telemedicine of patients with Parkinson’s disease during the COVID‐19 pandemic
    Kanako Kurihara, Koichi Nagaki, Kotoe Inoue, Sumiko Yamamoto, Takayasu Mishima, Shinsuke Fujioka, Shinji Ouma, Yoshio Tsuboi
    Neurology and Clinical Neuroscience.2021; 9(1): 77.     CrossRef
  • Risk of Hospitalization and Death for COVID ‐19 in People with Parkinson's Disease or Parkinsonism
    Luca Vignatelli, Corrado Zenesini, Laura M.B. Belotti, Elisa Baldin, Giuseppe Bonavina, Giovanna Calandra‐Buonaura, Pietro Cortelli, Carlo Descovich, Giovanni Fabbri, Giulia Giannini, Maria Guarino, Roberta Pantieri, Giuseppe Samoggia, Cesa Scaglione, Sus
    Movement Disorders.2021; 36(1): 1.     CrossRef
  • Impact of COVID-19 in the Mental Health in Elderly: Psychological and Biological Updates
    Roberta Eduarda Grolli, Maiqueli Eduarda Dama Mingoti, Amanda Gollo Bertollo, Adriana Remião Luzardo, João Quevedo, Gislaine Zilli Réus, Zuleide Maria Ignácio
    Molecular Neurobiology.2021; 58(5): 1905.     CrossRef
  • COVID-19: Implications for Sudden Death in Parkinson’s Disease
    Ana Claudia Fiorini, Marcelo Cunio Machado Fonseca, Carla Alessandra Scorza, Josef Finsterer, Antônio Márcio Rodrigues, Antônio-Carlos Guimarães de Almeida, Fulvio Alexandre Scorza
    Journal of Movement Disorders.2021; 14(1): 78.     CrossRef
  • Impact and Challenges of the COVID-19 Pandemic on Patients Requiring Botulinum Toxin A Treatment
    Azalea Tenerife Pajo, Adrian Isidoro Espiritu, Roland Dominic Go Jamora
    Journal of Movement Disorders.2021; 14(1): 29.     CrossRef
  • COVID-19 in age-related neurodegenerative diseases: is there a role for vitamin D3 as a possible therapeutic strategy?
    Milena de Barros Viana, Bárbara dos Anjos Rosário, Maria de Fátima Santana de Nazaré, Débora Estadella, Daniel Araki Ribeiro, Glauce Socorro de Barros Viana
    Reviews in the Neurosciences.2021; 32(2): 235.     CrossRef
  • How COVID-19 will boost remote exercise-based treatment in Parkinson’s disease: a narrative review
    Agnes Langer, Lucia Gassner, Anna Flotz, Sebastian Hasenauer, Jakob Gruber, Laurenz Wizany, Rochus Pokan, Walter Maetzler, Heidemarie Zach
    npj Parkinson's Disease.2021;[Epub]     CrossRef
  • Neurological Manifestation of SARS-CoV-2 Induced Inflammation and Possible Therapeutic Strategies Against COVID-19
    Dipak Kumar, Sadaf Jahan, Andleeb Khan, Arif Jamal Siddiqui, Neeru Singh Redhu, Wahajuddin, Johra Khan, Saeed Banwas, Bader Alshehri, Mohammed Alaidarous
    Molecular Neurobiology.2021; 58(7): 3417.     CrossRef
  • Auswirkungen der COVID-19 Pandemie auf die medizinische Versorgung von Patienten mit angeborenen Blutungsneigungen
    Martin Olivieri, Susan Halimeh, Cornelia Wermes, Wolf Hassenpflug, Katharina Holstein, Sylvia von Mackensen
    Das Gesundheitswesen.2021; 83(04): 282.     CrossRef
  • Parkinsonism hyperpyraexia syndrome in Parkinson's disease patients undergoing deep brain stimulation: An indirect consequence of COVID-19 lockdowns
    Onanong Phokaewvarangkul, Sasivimol Virameteekul, Roongroj Bhidayasiri
    Parkinsonism & Related Disorders.2021; 87: 39.     CrossRef
  • Clinical Profiles and Mortality of COVID ‐19 Inpatients with Parkinson's Disease in Germany
    Raphael Scherbaum, Eun Hae Kwon, Daniel Richter, Dirk Bartig, Ralf Gold, Christos Krogias, Lars Tönges
    Movement Disorders.2021; 36(5): 1049.     CrossRef
  • Chronic pain experience and health inequities during the COVID-19 pandemic in Canada: qualitative findings from the chronic pain & COVID-19 pan-Canadian study
    Lise Dassieu, M. Gabrielle Pagé, Anaïs Lacasse, Maude Laflamme, Vickie Perron, Audrée Janelle-Montcalm, Maria Hudspith, Gregg Moor, Kathryn Sutton, James M Thompson, Manon Choinière
    International Journal for Equity in Health.2021;[Epub]     CrossRef
  • The Influence of Coronavirus Disease-2019 (COVID-19) On Parkinson’s Disease: An Updated Systematic Review
    Vikash Jaiswal, Danah Alquraish, Zouina Sarfraz, Azza Sarfraz, Shavy Nagpal, Prakriti Singh Shrestha, Dattatreya Mukherjee, Prathima Guntipalli, Diana F. Sánchez Velazco, Arushee Bhatnagar, Saloni Savani, Elmjedina Halilaj, Samir Ruxmohan, Wilson Cueva
    Journal of Primary Care & Community Health.2021; 12: 215013272110397.     CrossRef
  • Personalized Medicine in Parkinson’s Disease: New Options for Advanced Treatments
    Takayasu Mishima, Shinsuke Fujioka, Takashi Morishita, Tooru Inoue, Yoshio Tsuboi
    Journal of Personalized Medicine.2021; 11(7): 650.     CrossRef
  • Parkinson's disease patients may have higher rates of Covid-19 mortality in Iran
    Mehri Salari, Masoud Etemadifar, Farzad Ashrafi, Davood Ommi, Zahra Aminzade, Sepand Tehrani Fateh
    Parkinsonism & Related Disorders.2021; 89: 90.     CrossRef
  • COVID-19 social distancing: negative effects on people with Parkinson disease and their associations with confidence for self-management
    Galit Yogev-Seligmann, Michal Kafri
    BMC Neurology.2021;[Epub]     CrossRef
  • Covid-19 in Parkinson's Disease treated by drugs or brain stimulation
    M. Salari, M. Etemadifar, A. Zali, Z. Aminzade, I. Navalpotro-Gomez, S. Tehrani Fateh
    Neurología.2021;[Epub]     CrossRef
  • Management of Parkinson’s Disease in the COVID-19 Pandemic and Future Perspectives in the Era of Vaccination
    Yue Hui Lau, Keng Ming Lau, Norlinah Mohamed Ibrahim
    Journal of Movement Disorders.2021; 14(3): 177.     CrossRef
  • Parkinson’s Disease and the COVID-19 Pandemic: A Review Article on the Association between SARS-CoV-2 and α-Synucleinopathy
    Smriti Sinha, Swati Mittal, Rupali Roy
    Journal of Movement Disorders.2021; 14(3): 184.     CrossRef
  • Impact of COVID‐19 on Patient Care, Training, and Research in Movement Disorders in MDS‐AOS Region
    Shweta Prasad, Hrishikesh Kumar, Roongroj Bhidayasiri, Pramod Kumar Pal
    Movement Disorders.2021; 36(11): 2457.     CrossRef
  • Secondary Impact of COVID-19 Pandemic on People with Parkinson’s Disease—Results of a Polish Online Survey
    Karolina Krzysztoń, Beata Mielańczuk-Lubecka, Jakub Stolarski, Anna Poznańska, Katarzyna Kępczyńska, Agata Zdrowowicz, Izabela Domitrz, Jan Kochanowski
    Brain Sciences.2021; 12(1): 26.     CrossRef
  • Neurological consultations and diagnoses in a large, dedicated COVID-19 university hospital
    Adalberto STUDART-NETO, Bruno Fukelmann GUEDES, Raphael de Luca e TUMA, Antonio Edvan CAMELO FILHO, Gabriel Taricani KUBOTA, Bruno Diógenes IEPSEN, Gabriela Pantaleão MOREIRA, Júlia Chartouni RODRIGUES, Maíra Medeiros Honorato FERRARI, Rafael Bernhart CAR
    Arquivos de Neuro-Psiquiatria.2020; 78(8): 494.     CrossRef
  • Potential impact and challenges associated with Parkinson’s disease patient care amidst the COVID-19 global pandemic
    Ali Elbeddini, Anthony To, Yasamin Tayefehchamani, Cindy Wen
    Journal of Clinical Movement Disorders.2020;[Epub]     CrossRef
  • COVID-19 and possible links with Parkinson’s disease and parkinsonism: from bench to bedside
    David Sulzer, Angelo Antonini, Valentina Leta, Anna Nordvig, Richard J. Smeyne, James E. Goldman, Osama Al-Dalahmah, Luigi Zecca, Alessandro Sette, Luigi Bubacco, Olimpia Meucci, Elena Moro, Ashley S. Harms, Yaqian Xu, Stanley Fahn, K. Ray Chaudhuri
    npj Parkinson's Disease.2020;[Epub]     CrossRef
  • Impact of Prolonged Lockdown due to COVID-19 in Patients with Parkinson's Disease
    Shweta Prasad, VikramVenkappayya Holla, Koti Neeraja, BharathKumar Surisetti, Nitish Kamble, Ravi Yadav, PramodKumar Pal
    Neurology India.2020; 68(4): 792.     CrossRef
  • The Effect of the COVID-19 Pandemic on People with Parkinson’s Disease
    Ethan G. Brown, Lana M. Chahine, Samuel M. Goldman, Monica Korell, Emerald Mann, Daniel R. Kinel, Vanessa Arnedo, Kenneth L. Marek, Caroline M. Tanner
    Journal of Parkinson's Disease.2020; 10(4): 1365.     CrossRef
  • Impact of COVID‐19 pandemic on mental health of patients with inherited bleeding disorders in Germany
    Sylvia Mackensen, Susan Halimeh, Manuela Siebert, Cornelia Wermes, Wolf Hassenpflug, Katharina Holstein, Martin Olivieri
    Haemophilia.2020;[Epub]     CrossRef
  • Impact of Coronavirus Disease 2019 Pandemic on Parkinson's Disease: A Cross‐Sectional Survey of 568 Spanish Patients
    Diego Santos‐García, Mila Oreiro, Patricia Pérez, Gemma Fanjul, Jose Manuel Paz González, María José Feal Painceiras, Carlos Cores Bartolomé, Lorena Valdés Aymerich, Carlos García Sancho, Maria del Mar Castellanos Rodrigo
    Movement Disorders.2020; 35(10): 1712.     CrossRef
  • The Impact of COVID ‐19 on Access to Parkinson's Disease Medication
    Julia Ling‐Yu Cheong, Zhao Hang Keith Goh, Connie Marras, Caroline M. Tanner, Meike Kasten, Alastair J. Noyce
    Movement Disorders.2020; 35(12): 2129.     CrossRef
  • Deep Brain Stimulation Battery Exhaustion during the COVID-19 Pandemic: Crisis within a Crisis
    Vikram Venkappayya Holla, Koti Neeraja, Bharath Kumar Surisetti, Shweta Prasad, Nitish Kamble, Dwarakanath Srinivas, Ravi Yadav, Pramod Kumar Pal
    Journal of Movement Disorders.2020; 13(3): 218.     CrossRef
  • Clinical Characteristics of Coronavirus Disease 2019 (COVID-19) among Patients at a Movement Disorders Center
    Joy Antonelle de Marcaida, Jeffrey Lahrmann, Duarte Machado, Lawrence Bluth, Michelle Dagostine, Maria Moro-de Casillas, Elena Bortan, Sulada Kanchana, Mark Alberts
    Geriatrics.2020; 5(3): 54.     CrossRef
  • Update on Neurological Manifestations of SARS-CoV-2
    Hisham Valiuddin, Almir Kalajdzic, James Rosati, Kevin Boehm, Dominique Hill
    Western Journal of Emergency Medicine.2020;[Epub]     CrossRef
  • Effects of COVID-19 Lockdown on Movement Disorders Patients With Deep Brain Stimulation: A Multicenter Survey
    Carla Piano, Francesco Bove, Tommaso Tufo, Isabella Imbimbo, Danilo Genovese, Alessandro Stefani, Massimo Marano, Antonella Peppe, Livia Brusa, Rocco Cerroni, Francesco Motolese, Enrico Di Stasio, Marianna Mazza, Antonio Daniele, Alessandro Olivi, Paolo C
    Frontiers in Neurology.2020;[Epub]     CrossRef
Original Article
Orthostatic and Supine Blood Pressures Are Associated with White Matter Hyperintensities in Parkinson Disease
Yoon-Sang Oh, Joong-Seok Kim, Kwang-Soo Lee
J Mov Disord. 2013;6(2):23-27.   Published online October 30, 2013
DOI: https://doi.org/10.14802/jmd.13006
  • 14,383 View
  • 96 Download
  • 45 Citations
AbstractAbstract PDF
Background and Purpose:

Several reports on the elderly population have suggested that orthostatic hypotension is associated with white matter hyperintensities (WMH); however, little information is available on patients with Parkinson’s disease (PD).

 Methods:

We analyzed the association blood pressure profiles during tilt table testing with WMH scores in 117 patients with PD. WMH were rated using the semiquantitative visual rating system proposed by Scheltens et al.

 Results:

The presence of orthostatic hypotension was associated with increasing tendency of WMH score and the blood pressure changes during tilting and supine blood pressure were positively correlated with increasing WMH score.

 Conclusions:

This finding indicates that hemodynamic changes associated with orthostatic hypotension may be associated with white matter changes in patients with PD.

Citations

Citations to this article as recorded by  
  • Association Between Gait and Dysautonomia in Patients With De Novo Parkinson’s Disease: Forward Gait Versus Backward Gait
    Seon-Min Lee, Mina Lee, Eun Ji Lee, Rae On Kim, Yongduk Kim, Kyum-Yil Kwon
    Journal of Movement Disorders.2023; 16(1): 59.     CrossRef
  • Association Between Orthostatic Hypotension and Dementia in Patients With Parkinson Disease and Multiple System Atrophy
    Iñigo Ruiz Barrio, Yasuo Miki, Zane T. Jaunmuktane, Thomas Warner, Eduardo De Pablo-Fernandez
    Neurology.2023; 100(10): e998.     CrossRef
  • Central retinal microvasculature damage is associated with orthostatic hypotension in Parkinson’s disease
    Jong Hyeon Ahn, Min Chae Kang, Dongyoung Lee, Jin Whan Cho, Kyung-Ah Park, Jinyoung Youn
    npj Parkinson's Disease.2023;[Epub]     CrossRef
  • Interventions for orthostatic hypotension in Parkinson's disease: a systematic review and network meta-analysis
    Kunshan Li, Luyi Wu, Xuejun Cui, Wei Zhang, Jun Ji, Yiwen Wu, Zhaoqin Wang, Huirong Liu, Huangan Wu, Lu Zhu
    Cochrane Database of Systematic Reviews.2023;[Epub]     CrossRef
  • Autonomic control of heart and vessels in patients with very early stage of Parkinson disease
    J Oleksakova, M Javorka, B Czippelova, N Mazgutova, M Grofik, L Babalova, P Skacik, E Kurca
    Physiological Measurement.2023; 44(5): 054002.     CrossRef
  • REM sleep behavioral disorder may be an independent risk factor for orthostatic hypotension in Parkinson’s disease
    Kangfu Yin, Chuanbin Zhou, Yongyun Zhu, Weifang Yin, Lei Yin, Bin Liu, Hui Ren, Zhong Xu, Xinglong Yang
    Aging Clinical and Experimental Research.2022; 34(1): 159.     CrossRef
  • Parkinsonism and cerebrovascular disease
    Manisha Narasimhan, Raymond Schwartz, Glenda Halliday
    Journal of the Neurological Sciences.2022; 433: 120011.     CrossRef
  • Arterial Blood Pressure Variability and Other Vascular Factors Contribution to the Cognitive Decline in Parkinson’s Disease
    Anna Pierzchlińska, Magdalena Kwaśniak-Butowska, Jarosław Sławek, Marek Droździk, Monika Białecka
    Molecules.2021; 26(6): 1523.     CrossRef
  • Adverse effects of hypertension, supine hypertension, and perivascular space on cognition and motor function in PD
    Na-Young Shin, Yae Won Park, Sang-Won Yoo, Ji-Yeon Yoo, Yangsean Choi, Jinhee Jang, Kook-Jin Ahn, Bum-soo Kim, Joong-Seok Kim
    npj Parkinson's Disease.2021;[Epub]     CrossRef
  • Association of Orthostatic Hypotension With Cerebral Atrophy in Patients With Lewy Body Disorders
    Andrea Pilotto, Alberto Romagnolo, Andrea Scalvini, Mario Masellis, Yasushi Shimo, Laura Bonanni, Richard Camicioli, Lily L. Wang, Alok K. Dwivedi, Katherine Longardner, Federico Rodriguez-Porcel, Mark DiFrancesco, Joaquin A. Vizcarra, Elisa Montanaro, Si
    Neurology.2021; 97(8): e814.     CrossRef
  • Small vessel disease pathological changes in neurodegenerative and vascular dementias concomitant with autonomic dysfunction
    Yoshiki Hase, Tuomo M. Polvikoski, Michael J. Firbank, Lucinda J. L. Craggs, Emily Hawthorne, Charlotte Platten, William Stevenson, Vincent Deramecourt, Clive Ballard, Rose Anne Kenny, Robert H. Perry, Paul Ince, Roxana O. Carare, Louise M. Allan, Karen H
    Brain Pathology.2020; 30(1): 191.     CrossRef
  • Neurovascular unit dysregulation, white matter disease, and executive dysfunction: the shared triad of vascular cognitive impairment and Alzheimer disease
    Alexander Levit, Vladimir Hachinski, Shawn N. Whitehead
    GeroScience.2020; 42(2): 445.     CrossRef
  • The impact of supine hypertension on target organ damage and survival in patients with synucleinopathies and neurogenic orthostatic hypotension
    Jose-Alberto Palma, Gabriel Redel-Traub, Angelo Porciuncula, Daniela Samaniego-Toro, Patricio Millar Vernetti, Yvonne W. Lui, Lucy Norcliffe-Kaufmann, Horacio Kaufmann
    Parkinsonism & Related Disorders.2020; 75: 97.     CrossRef
  • White Matter Hyperintensities in the Synucleinopathies: Orthostatic Hypotension, Supine Hypertension, or Both?
    Horacio Kaufmann, Jose‐Alberto Palma
    Movement Disorders Clinical Practice.2020; 7(6): 595.     CrossRef
  • White Matter Hyperintensities Mediate Impact of Dysautonomia on Cognition in Parkinson's Disease
    Mahsa Dadar, Seyed‐Mohammad Fereshtehnejad, Yashar Zeighami, Alain Dagher, Ronald B. Postuma, D. Louis Collins
    Movement Disorders Clinical Practice.2020; 7(6): 639.     CrossRef
  • Blood pressure lability is associated with subcortical atrophy in early Parkinson's disease
    Sang-Won Yoo, Eunkyeong Yun, Mirim Bang, Uicheul Yoon, Ji-Yeon Yoo, Kwang-Soo Lee, Na-Young Shin, Joong-Seok Kim
    Journal of Hypertension.2020; 38(10): 2043.     CrossRef
  • Orthostatic hypotension, dizziness, neurology outcomes, and death in older adults
    Stephen P. Juraschek, W.T. Longstreth, Oscar L. Lopez, John S. Gottdiener, Lewis A. Lipsitz, Lewis H. Kuller, Kenneth J. Mukamal
    Neurology.2020; 95(14): e1941.     CrossRef
  • Cross-sectional and longitudinal associations between total and regional white matter hyperintensity volume and cognitive and motor function in Parkinson's disease
    Vincent Pozorski, Jennifer M. Oh, Ozioma Okonkwo, Stephanie Krislov, Amy Barzgari, Frances Theisen, Jitka Sojkova, Barbara B. Bendlin, Sterling C. Johnson, Catherine L. Gallagher
    NeuroImage: Clinical.2019; 23: 101870.     CrossRef
  • Magnetic Resonance Imaging–Visible Perivascular Spaces in Basal Ganglia Predict Cognitive Decline in Parkinson's Disease
    Yae Won Park, Na‐Young Shin, Seok Jong Chung, Jiwoong Kim, Soo Mee Lim, Phil Hyu Lee, Seung‐Koo Lee, Kook Jin Ahn
    Movement Disorders.2019; 34(11): 1672.     CrossRef
  • Orthostatic hypotension in Parkinson disease
    Ylva Hivand Hiorth, Kenn Freddy Pedersen, Ingvild Dalen, Ole-Bjørn Tysnes, Guido Alves
    Neurology.2019; 93(16): e1526.     CrossRef
  • Dysautonomia is associated with structural and functional alterations in Parkinson disease
    Seok Jong Chung, Youn Jung Bae, Suhnyoung Jun, Han Soo Yoo, Seung Woo Kim, Yang Hyun Lee, Young H. Sohn, Seung-Koo Lee, Joon-Kyung Seong, Phil Hyu Lee
    Neurology.2019; 92(13): e1456.     CrossRef
  • Consensus statement on the definition of neurogenic supine hypertension in cardiovascular autonomic failure by the American Autonomic Society (AAS) and the European Federation of Autonomic Societies (EFAS)
    Alessandra Fanciulli, Jens Jordan, Italo Biaggioni, Giovanna Calandra–Buonaura, William P. Cheshire, Pietro Cortelli, Sabine Eschlboeck, Guido Grassi, Max J. Hilz, Horacio Kaufmann, Heinz Lahrmann, Giuseppe Mancia, Gert Mayer, Lucy Norcliffe–Kaufmann, Ann
    Clinical Autonomic Research.2018; 28(4): 355.     CrossRef
  • Reverse blood pressure dipping as marker of dysautonomia in Parkinson disease
    Valeria Milazzo, Cristina Di Stefano, Fabrizio Vallelonga, Gabriele Sobrero, Maurizio Zibetti, Alberto Romagnolo, Aristide Merola, Alberto Milan, Alberto J. Espay, Leonardo Lopiano, Franco Veglio, Simona Maule
    Parkinsonism & Related Disorders.2018; 56: 82.     CrossRef
  • White matter hyperintensities are linked to future cognitive decline in de novo Parkinson's disease patients
    Mahsa Dadar, Yashar Zeighami, Yvonne Yau, Seyed-Mohammad Fereshtehnejad, Josefina Maranzano, Ronald B. Postuma, Alain Dagher, D. Louis Collins
    NeuroImage: Clinical.2018; 20: 892.     CrossRef
  • Rapid Systolic Blood Pressure Changes After Standing Up Associate With Impaired Physical Performance in Geriatric Outpatients
    Arjen Mol, Esmee M. Reijnierse, Marijke C. Trappenburg, Richard J. A. van Wezel, Andrea B. Maier, Carel G. M. Meskers
    Journal of the American Heart Association.2018;[Epub]     CrossRef
  • Central hemodynamics and arterial stiffness in idiopathic and multiple system atrophy
    Klaas Franzen, Sabine Fliegen, Jelena Koester, Rafael Campos Martin, Günther Deuschl, Michael Reppel, Kai Mortensen, Susanne A. Schneider
    Journal of Neurology.2017; 264(2): 327.     CrossRef
  • Cardiovascular Autonomic Dysfunction in Patients with Drug-Induced Parkinsonism
    Joong-Seok Kim, Dong-Woo Ryu, Ju-Hee Oh, Yang-Hyun Lee, Sung-Jin Park, Kipyung Jeon, Jong-Yun Lee, Seong Hee Ho, Jungmin So, Jin Hee Im, Kwang-Soo Lee
    Journal of Clinical Neurology.2017; 13(1): 15.     CrossRef
  • Association of arterial stiffness with cognition in patients with Lewy body disorder
    Dong-Woo Ryu, Joong-Seok Kim, Jee-Eun Lee, Jeong-Wook Park, Yoon-Sang Oh, Jae-Young An, Kwang-Soo Lee
    Neurological Sciences.2017; 38(7): 1307.     CrossRef
  • Microstructural integrity of white matter tracts amongst older fallers: A DTI study
    Yoke Queen Wong, Li Kuo Tan, Pohchoo Seow, Maw Pin Tan, Khairul Azmi Abd Kadir, Anushya Vijayananthan, Norlisah Ramli, Gianluigi Forloni
    PLOS ONE.2017; 12(6): e0179895.     CrossRef
  • Cerebral autoregulation is preserved in multiple sclerosis patients
    Daniel Ferreira, Pedro Castro, Gonçalo Videira, João Pedro Filipe, Rosa Santos, Maria José Sá, Elsa Azevedo, Pedro Abreu
    Journal of the Neurological Sciences.2017; 381: 298.     CrossRef
  • Long-term Levodopa Treatment Accelerates the Circadian Rhythm Dysfunction in a 6-hydroxydopamine Rat Model of Parkinson's Disease
    Si-Yue Li, Ya-Li Wang, Wen-Wen Liu, Dong-Jun Lyu, Fen Wang, Cheng-Jie Mao, Ya-Ping Yang, Li-Fang Hu, Chun-Feng Liu
    Chinese Medical Journal.2017; 130(9): 1085.     CrossRef
  • Arterial Stiffness and Cardiovascular Autonomic Dysfunction in Patients with Parkinson's Disease
    Joong-Seok Kim, Si-Hoon Lee, Yoon-Sang Oh, Jeong-Wook Park, Jae-Young An, Hyun-Seok Choi, Kwang-Soo Lee
    Neurodegenerative Diseases.2017; 17(2-3): 89.     CrossRef
  • Cardiovascular autonomic dysfunctions in elderly patients with essential tremor: comparison with healthy controls
    Joong-Seok Kim, Yoon-Sang Oh, Hyung-Eun Park, Si-Hoon Lee, Jeong-Wook Park, In-Uk Song, Jae-Young An, Hun-Jun Park, Byung-Chul Son, Kwang-Soo Lee
    Neurological Sciences.2016; 37(5): 711.     CrossRef
  • Orthostatic hypotension and cardiac sympathetic denervation in Parkinson disease patients with REM sleep behavioral disorder
    Joong-Seok Kim, Hyung-Eun Park, Yoon-Sang Oh, Si-Hoon Lee, Jeong-Wook Park, Byung-chul Son, Kwang-Soo Lee
    Journal of the Neurological Sciences.2016; 362: 59.     CrossRef
  • Supine hypertension in Parkinson’s disease and multiple system atrophy
    Alessandra Fanciulli, Georg Göbel, Jean Pierre Ndayisaba, Roberta Granata, Susanne Duerr, Stefano Strano, Carlo Colosimo, Werner Poewe, Francesco E. Pontieri, Gregor K. Wenning
    Clinical Autonomic Research.2016; 26(2): 97.     CrossRef
  • Orthostatic hypotension and cognitive impairment in Parkinson's disease: Causation or association?
    Claire McDonald, Julia L. Newton, David J. Burn
    Movement Disorders.2016; 31(7): 937.     CrossRef
  • Cardiovascular Autonomic Dysfunction in Mild and Advanced Parkinson’s Disease
    Joong-Seok Kim, Si-Hoon Lee, Yoon-Sang Oh, Jeong-Wook Park, Jae-Young An, Sung-Kyung Park, Si-Ryung Han, Kwang-Soo Lee
    Journal of Movement Disorders.2016; 9(2): 97.     CrossRef
  • Autonomic Nervous System Dysfunction in Patients With Parkinson Disease Having Depression
    Hyung-Eun Park, Joong-Seok Kim, Yoon-Sang Oh, In-Seok Park, Jeong-Wook Park, In-Uk Song, Kwang-Soo Lee
    Journal of Geriatric Psychiatry and Neurology.2016; 29(1): 11.     CrossRef
  • Vascular cognitive impairment, a cardiovascular complication
    Adiukwu Frances, Ofori Sandra, Ugbomah Lucy
    World Journal of Psychiatry.2016; 6(2): 199.     CrossRef
  • Cardiovascular complications in patients with autonomic failure
    Valeria Milazzo, Cristina Di Stefano, Alberto Milan, Agnese Ravera, Gabriele Sobrero, Luca Sabia, Franco Veglio, Simona Maule
    Clinical Autonomic Research.2015; 25(3): 133.     CrossRef
  • 123I-MIBG myocardial scintigraphy and neurocirculatory abnormalities in patients with dementia with Lewy bodies and Alzheimer's disease
    Joong-Seok Kim, Hyung-Eun Park, Yoon-Sang Oh, In-Uk Song, Dong-Won Yang, Jeong-Wook Park, Kwang-Soo Lee
    Journal of the Neurological Sciences.2015; 357(1-2): 173.     CrossRef
  • Diagnosing and treating neurogenic orthostatic hypotension in primary care
    Louis Kuritzky, Alberto J. Espay, Jeffrey Gelblum, Richard Payne, Eric Dietrich
    Postgraduate Medicine.2015; 127(7): 702.     CrossRef
  • Increased CSF biomarkers of angiogenesis in Parkinson disease
    Shorena Janelidze, Daniel Lindqvist, Veronica Francardo, Sara Hall, Henrik Zetterberg, Kaj Blennow, Charles H. Adler, Thomas G. Beach, Geidy E. Serrano, Danielle van Westen, Elisabet Londos, M. Angela Cenci, Oskar Hansson
    Neurology.2015; 85(21): 1834.     CrossRef
  • Orthostatic hypotension, cerebral hypoperfusion, and visuospatial deficits in Lewy body disorders
    Andrew D. Robertson, Michelle A. Messner, Zahra Shirzadi, Galit Kleiner-Fisman, Joyce Lee, Julia Hopyan, Anthony E. Lang, Sandra E. Black, Bradley J. MacIntosh, Mario Masellis
    Parkinsonism & Related Disorders.2015;[Epub]     CrossRef
  • Orthostatic Hypotension and Cognitive Impairment in <i>De Novo</i> Patients with Parkinson’s Disease
    Hyo-Jin Bae, Jun-Ho Lim, Sang-Myung Cheon
    Journal of Movement Disorders.2014; 7(2): 102.     CrossRef
Review Articles
Clinical Approach to Progressive Supranuclear Palsy
Helen Ling
J Mov Disord. 2016;9(1):3-13.   Published online January 25, 2016
DOI: https://doi.org/10.14802/jmd.15060
  • 32,642 View
  • 1,158 Download
  • 42 Citations
AbstractAbstract PDF
Sixty years ago, Steele, Richardson and Olszewski designated progressive supranuclear palsy (PSP) as a new clinicopathological entity in their seminal paper. Since then, in addition to the classic Richardson’s syndrome (RS), different clinical phenotypic presentations have been linked with this four-repeat tauopathy. The clinical heterogeneity is associated with variability of regional distribution and severity of abnormal tau accumulation and neuronal loss. In PSP subtypes, the presence of certain clinical pointers may be useful for antemortem prediction of the underlying PSP-tau pathology. Midbrain atrophy on conventional MRI correlates with the clinical phenotype of RS but is not predictive of PSP pathology. Cerebrospinal fluid biomarkers and tau ligand positron emission tomography are promising biomarkers of PSP. A multidisciplinary approach to meet the patients’ complex needs is the current core treatment strategy for this devastating disorder.

Citations

Citations to this article as recorded by  
  • Existing statistical measures and techniques in detecting and evaluating progressive supranuclear palsy, its phenotypes by using MRI modalities: A Review
    Nirmal Adam Sait, J Kathirvelan
    Materials Today: Proceedings.2023; 80: 2000.     CrossRef
  • The role of magnetic resonance imaging in the diff erential diagnosis of Parkinson’s disease
    A. A. Tappakhov, T. E. Popova
    Russian neurological journal.2023; 28(1): 5.     CrossRef
  • Midbrain area and the hummingbird sign from brain MRI in progressive supranuclear palsy and idiopathic normal pressure hydrocephalus
    Johan Virhammar, Harald Blohmé, Dag Nyholm, Charalampos Georgiopoulos, David Fällmar
    Journal of Neuroimaging.2022; 32(1): 90.     CrossRef
  • Cognitive, Psychiatric, and Motor Symptoms–Based Algorithmic Approach to Differentiate Among Various Types of Dementia Syndromes
    Rehab Magdy, Mona Hussein
    Journal of Nervous & Mental Disease.2022; 210(2): 129.     CrossRef
  • Idiopathic normal pressure hydrocephalus-like MRI features in patients with progressive supranuclear palsy: a comparative case-control study
    Halil Onder, Bilge Kocer, Selcuk Comoglu
    Neurological Research.2022; 44(9): 807.     CrossRef
  • Targeting alpha-synuclein or tau for treating neurodegenerative movement disorders
    M. Lopez-Cuina, W.G. Meissner
    Revue Neurologique.2022; 178(5): 460.     CrossRef
  • Clinical Aspects of the Differential Diagnosis of Parkinson’s Disease and Parkinsonism
    Hae-Won Shin, Sang-Wook Hong, Young Chul Youn
    Journal of Clinical Neurology.2022; 18(3): 259.     CrossRef
  • Dopamine transporter imaging in progressive supranuclear palsy: Severe but nonspecific to subtypes
    Qi‐Si Chen, Xin‐Yi Li, Ling Li, Jia‐Ying Lu, Yi‐Min Sun, Feng‐Tao Liu, Chuan‐Tao Zuo, Jian Wang
    Acta Neurologica Scandinavica.2022; 146(3): 237.     CrossRef
  • CSF tau microtubule-binding region identifies pathological changes in primary tauopathies
    Kanta Horie, Nicolas R. Barthélemy, Salvatore Spina, Lawren VandeVrede, Yingxin He, Ross W. Paterson, Brenton A. Wright, Gregory S. Day, Albert A. Davis, Celeste M. Karch, William W. Seeley, Richard J. Perrin, Rama K. Koppisetti, Faris Shaikh, Argentina L
    Nature Medicine.2022; 28(12): 2547.     CrossRef
  • Genetics of Progressive Supranuclear Palsy: A Review
    Yafei Wen, Yafang Zhou, Bin Jiao, Lu Shen
    Journal of Parkinson's Disease.2021; 11(1): 93.     CrossRef
  • Disease course and treatment patterns in progressive supranuclear palsy: A real-world study
    John C. Morgan, Xiaolan Ye, Jennifer A. Mellor, Keisha J. Golden, Jorge Zamudio, Louis A. Chiodo, Yanjun Bao, Tao Xie
    Journal of the Neurological Sciences.2021; 421: 117293.     CrossRef
  • Central nystagmus in progressive supranuclear palsy: A neglected clinical feature?
    Maja Klarendic, Manja Hribar, Nina Bozanic Urbancic, Nina Zupancic, Milica G. Kramberger, Maja Trost, Saba Battelino, Diego Kaski, Maja Kojovic
    Parkinsonism & Related Disorders.2021; 84: 15.     CrossRef
  • Safety and efficacy of tilavonemab in progressive supranuclear palsy: a phase 2, randomised, placebo-controlled trial
    Günter U Höglinger, Irene Litvan, Nuno Mendonca, Deli Wang, Hui Zheng, Beatrice Rendenbach-Mueller, Hoi-Kei Lon, Ziyi Jin, Nahome Fisseha, Kumar Budur, Michael Gold, Davis Ryman, Hana Florian, Anwar Ahmed, Ikuko Aiba, Alberto Albanese, Kelly Bertram, Yvet
    The Lancet Neurology.2021; 20(3): 182.     CrossRef
  • A Study on the Essential and Parkinson’s Arm Tremor Classification
    Vasileios Skaramagkas, George Andrikopoulos, Zinovia Kefalopoulou, Panagiotis Polychronopoulos
    Signals.2021; 2(2): 201.     CrossRef
  • Progressive Supranuclear Palsy: Improvement in Cognitive-Behavioral Disturbances and Motor-Function Disabilities Following Treatment With Antidepressants and Cholinesterase Inhibitors
    Michelle Oyeka, Terngu Ibilah, Jacob Israel, Jose Gavito-Higuera, Ricardo Salazar
    Cureus.2021;[Epub]     CrossRef
  • Progressive supranuclear palsy
    N.V. Fedorova, E.V. Bril, T.K. Kulua, A.D. Mikhaylova
    Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova.2021; 121(5): 111.     CrossRef
  • Best Practices in the Clinical Management of Progressive Supranuclear Palsy and Corticobasal Syndrome: A Consensus Statement of the CurePSP Centers of Care
    Brent Bluett, Alexander Y. Pantelyat, Irene Litvan, Farwa Ali, Diana Apetauerova, Danny Bega, Lisa Bloom, James Bower, Adam L. Boxer, Marian L. Dale, Rohit Dhall, Antoine Duquette, Hubert H. Fernandez, Jori E. Fleisher, Murray Grossman, Michael Howell, Di
    Frontiers in Neurology.2021;[Epub]     CrossRef
  • The Genetic Landscape of Parkinsonism-Related Dystonias and Atypical Parkinsonism-Related Syndromes
    Monica Diez-Fairen, Pilar Alvarez Jerez, Joos Berghausen, Sara Bandres-Ciga
    International Journal of Molecular Sciences.2021; 22(15): 8100.     CrossRef
  • MAPT R406W increases tau T217 phosphorylation in absence of amyloid pathology
    Chihiro Sato, Nipun Mallipeddi, Nupur Ghoshal, Brenton A. Wright, Gregory S. Day, Albert A. Davis, Albert H. Kim, Gregory J. Zipfel, Randall J. Bateman, Audrey Gabelle, Nicolas R. Barthélemy
    Annals of Clinical and Translational Neurology.2021; 8(9): 1817.     CrossRef
  • “Parkinson’s disease” on the way to progressive supranuclear palsy: a review on PSP-parkinsonism
    Ján Necpál, Miroslav Borsek, Bibiána Jeleňová
    Neurological Sciences.2021; 42(12): 4927.     CrossRef
  • Estimation and discussion of prognosis in neurologic practice. Communication issues with patient with neurological disease
    E. V. Bril, A. V. Khasina, F. A. Abbasov, O. S. Zimnyakova, N. V. Fedorova
    Medical alphabet.2021; (22): 55.     CrossRef
  • The Progressive Supranuclear Palsy: Past and Present Aspects
    Theodore P. Parthimos, Kleopatra H. Schulpis
    Clinical Gerontologist.2020; 43(2): 155.     CrossRef
  • Machine Learning Techniques to Identify Dementia
    Nivedita Manohar Mathkunti, Shanta Rangaswamy
    SN Computer Science.2020;[Epub]     CrossRef
  • My dad and progressive supranuclear palsy (PSP)
    Heather Angus-Leppan
    Practical Neurology.2020; 20(3): 263.     CrossRef
  • Tauopathy and Movement Disorders—Unveiling the Chameleons and Mimics
    Jacky Ganguly, Mandar Jog
    Frontiers in Neurology.2020;[Epub]     CrossRef
  • A Home-Based, Music-Cued Movement Program Is Feasible and May Improve Gait in Progressive Supranuclear Palsy
    Joanne E. Wittwer, Margaret Winbolt, Meg E. Morris
    Frontiers in Neurology.2019;[Epub]     CrossRef
  • Association of autonomic symptoms with disease progression and survival in progressive supranuclear palsy
    Marcos C B Oliveira, Helen Ling, Andrew J Lees, Janice L Holton, Eduardo De Pablo-Fernandez, Thomas T Warner
    Journal of Neurology, Neurosurgery & Psychiatry.2019; 90(5): 555.     CrossRef
  • Revisiting the diagnostic value of Evans’ index: lessons from an unusual case of normal pressure hydrocephalus with Evans’ index less than 0.3
    Jung E. Park, Hyunjin Ju, Kayeong Im, Kyum-Yil Kwon
    Neurological Sciences.2019; 40(12): 2637.     CrossRef
  • Progressive supranuclear palsy as differential diagnosis of Parkinson's disease in the elderly
    Ricardo Fernández-Ferreira, Raúl Anwar García-Santos, Mayela Rodríguez-Violante, Coral López-Martínez, Ivonne Karina Becerra-Laparra, María Eugenia Torres-Pérez
    Revista Española de Geriatría y Gerontología.2019; 54(5): 251.     CrossRef
  • Neuroinflammation as a Common Feature of Neurodegenerative Disorders
    Leonardo Guzman-Martinez, Ricardo B. Maccioni, Víctor Andrade, Leonardo Patricio Navarrete, María Gabriela Pastor, Nicolas Ramos-Escobar
    Frontiers in Pharmacology.2019;[Epub]     CrossRef
  • On the journey to uncover the causes of selective cellular and regional vulnerability in neurodegeneration
    Zane Jaunmuktane, Sebastian Brandner
    Acta Neuropathologica.2019; 138(5): 677.     CrossRef
  • Clinical Milestones Preceding the Diagnosis of Multiple System Atrophy and Progressive Supranuclear Palsy: A Retrospective Cohort Study
    Louise Wiblin, Rory Durcan, Brook Galna, Mark Lee, David Burn
    Journal of Movement Disorders.2019; 12(3): 177.     CrossRef
  • Prediction of the Clinical Severity of Progressive Supranuclear Palsy by Diffusion Tensor Imaging
    Yao-Liang Chen, Xiang-An Zhao, Shu-Hang Ng, Chin-Song Lu, Yu-Chun Lin, Jur-Shan Cheng, Chih-Chien Tsai, Jiun-Jie Wang
    Journal of Clinical Medicine.2019; 9(1): 40.     CrossRef
  • Tauopathy with hippocampal 4-repeat tau immunoreactive spherical inclusions: a report of three cases
    Gabor G. Kovacs, Linda K. Kwong, Murray Grossman, David J. Irwin, Edward B. Lee, John L. Robinson, Eunran Suh, Vivianna M. Van Deerlin, Virginia M. Lee, John Q. Trojanowski
    Brain Pathology.2018; 28(2): 274.     CrossRef
  • A case of spinal anesthesia in a patient with progressive supranuclear palsy
    Momoka Tonan, Moritoki Egi, Nana Furushima, Satoshi Mizobuchi
    JA Clinical Reports.2018;[Epub]     CrossRef
  • Is it Useful to Classify PSP and CBD as Different Disorders? Yes
    Helen Ling, Antonella Macerollo
    Movement Disorders Clinical Practice.2018; 5(2): 145.     CrossRef
  • Difficulties in the diagnosis of four repeats (4R) tauopathic parkinsonian syndromes
    Piotr Alster, Ewa Krzyżanowska, Dariusz Koziorowski, Stanisław Szlufik, Dorota Różański, Joanna Noskowska, Justyna Mianowicz, Adrian Michno, Leszek Królicki, Andrzej Friedman
    Neurologia i Neurochirurgia Polska.2018; 52(4): 459.     CrossRef
  • Neuro-ophthalmology of movement disorders
    Olga Waln, Joseph Jankovic
    Expert Review of Ophthalmology.2018; 13(5): 283.     CrossRef
  • Role of Neuroimaging on Differentiation of Parkinson’s Disease and Its Related Diseases
    Toshihide Ogawa, Shinya Fujii, Keita Kuya, Shin-ichiro Kitao, Yuki Shinohara, Mana Ishibashi, Yoshio Tanabe
    Yonago Acta Medica.2018; 61(3): 145.     CrossRef
  • Gait disorders in adults and the elderly
    Walter Pirker, Regina Katzenschlager
    Wiener klinische Wochenschrift.2017; 129(3-4): 81.     CrossRef
  • Transcranial Magnetic Stimulation for the Assessment of Neurodegenerative Disease
    Steve Vucic, Matthew C. Kiernan
    Neurotherapeutics.2017; 14(1): 91.     CrossRef
  • Advances in progressive supranuclear palsy: new diagnostic criteria, biomarkers, and therapeutic approaches
    Adam L Boxer, Jin-Tai Yu, Lawrence I Golbe, Irene Litvan, Anthony E Lang, Günter U Höglinger
    The Lancet Neurology.2017; 16(7): 552.     CrossRef
123I-Metaiodobenzylguanidine Myocardial Scintigraphy in Lewy Body-Related Disorders: A Literature Review
Eun Joo Chung, Sang Jin Kim
J Mov Disord. 2015;8(2):55-66.   Published online May 31, 2015
DOI: https://doi.org/10.14802/jmd.15015
  • 16,640 View
  • 179 Download
  • 42 Citations
AbstractAbstract PDF
Lewy body-related disorders are characterized by the presence of Lewy bodies and Lewy neurites, which have abnormal aggregations of α-synuclein in the nigral and extranigral areas, including in the heart. 123I-metaiodobenzylguanidine (MIBG) scintigraphy is a well-known tool to evaluate cardiac sympathetic denervation in the Lewy body-related disorders. MIBG scintigraphy showed low uptake of MIBG in the Lewy body-related disorders, including Parkinson’s disease, dementia with Lewy bodies, pure autonomic failure and rapid eye movement sleep behavior disorder. This review summarizes previous results on the diagnostic applications of MIBG scintigraphy in Lewy body-related disorders.

Citations

Citations to this article as recorded by  
  • Sudden cardiac death in synucleinopathies
    Keivan Javanshiri, Tove Drakenberg, Mattias Haglund, Elisabet Englund
    Journal of Neuropathology & Experimental Neurology.2023; 82(3): 242.     CrossRef
  • Optimal Protocol and Clinical Usefulness of 123I-MIBG Cardiac Scintigraphy for Differentiation of Parkinson’s Disease and Dementia with Lewy Body from Non-Parkinson’s Diseases
    In Kook Chun
    Nuclear Medicine and Molecular Imaging.2023; 57(3): 145.     CrossRef
  • Differentiating Dementia with Lewy Bodies from Alzheimer's Disease Using the Fall Risk Evaluation Questionnaire
    Masashi Tsujimoto, Keisuke Suzuki, Akinori Takeda, Naoki Saji, Takashi Sakurai, Yukihiko Washimi
    Internal Medicine.2022; 61(11): 1687.     CrossRef
  • Association of plasma α-synuclein with cardiac 123I-MIBG scintigraphy in early Parkinson’s disease
    Don Gueu Park, Juhee Kang, Young-Sil An, Jaerak Chang, Jung Han Yoon
    Neuroscience Letters.2022; 770: 136399.     CrossRef
  • Clinical and imaging evidence of brain-first and body-first Parkinson's disease
    Jacob Horsager, Karoline Knudsen, Michael Sommerauer
    Neurobiology of Disease.2022; 164: 105626.     CrossRef
  • Cardiac Alpha-Synuclein Is Present in Alpha-Synucleinopathies
    Keivan Javanshiri, Tove Drakenberg, Mattias Haglund, Elisabet Englund
    Journal of Parkinson's Disease.2022; 12(4): 1125.     CrossRef
  • Cardiac 123I-MIBG normal uptake values are population-specific: Results from a cohort of controls over 60 years of age
    G. Roberts, J. J. Lloyd, J. P. M. Kane, R. Durcan, S. Lawley, K. Howe, G. S. Petrides, J. T. O’Brien, A. J. Thomas
    Journal of Nuclear Cardiology.2021; 28(4): 1692.     CrossRef
  • Uniformity of cardiac 123I-MIBG uptake on SPECT images in older adults with normal cognition and patients with dementia
    Gemma Roberts, Jim J. Lloyd, Elizabeth Jefferson, Joseph P. M. Kane, Rory Durcan, Sarah Lawley, George S. Petrides, Kim Howe, Iftikhar Haq, John T. O’Brien, Alan J. Thomas
    Journal of Nuclear Cardiology.2021; 28(5): 2151.     CrossRef
  • Myocardial Sympathetic Innervation Imaging with MIBG in Dementia with Lewy Bodies
    Gagandeep Choudhary, Pradeep Bhambhvani
    Journal of Nuclear Cardiology.2021; 28(5): 2164.     CrossRef
  • Identification of BAG2 and Cathepsin D as Plasma Biomarkers for Parkinson’s Disease
    Juhee Kang, Jae Whan Kim, Hansol Heo, Jihyun Lee, Kwan Yong Park, Jung Han Yoon, Jaerak Chang
    Clinical and Translational Science.2021; 14(2): 606.     CrossRef
  • Gastrointestinal Dysfunction in Parkinson’s Disease
    Casper Skjærbæk, Karoline Knudsen, Jacob Horsager, Per Borghammer
    Journal of Clinical Medicine.2021; 10(3): 493.     CrossRef
  • Management of Hypertension and Blood Pressure Dysregulation in Patients with Parkinson’s Disease—a Systematic Review
    Vasiliki Katsi, Ilias Papakonstantinou, Eirini Solomou, Alexios S. Antonopoulos, Charalambos Vlachopoulos, Konstantinos Tsioufis
    Current Hypertension Reports.2021;[Epub]     CrossRef
  • Lewy Body Dementias: A Coin with Two Sides?
    Ángela Milán-Tomás, Marta Fernández-Matarrubia, María Cruz Rodríguez-Oroz
    Behavioral Sciences.2021; 11(7): 94.     CrossRef
  • Cardiac Autonomic Dysfunction Is Associated with Severity of REM Sleep without Atonia in Isolated REM Sleep Behavior Disorder
    Sooyeoun You, Kyoung Sook Won, Keun Tae Kim, Hyang Woon Lee, Yong Won Cho
    Journal of Clinical Medicine.2021; 10(22): 5414.     CrossRef
  • A diagnostic strategy for Lewy body disease using DAT-SPECT, MIBG and Combined index
    Fumi Sakamoto, Shinya Shiraishi, Koji Ogasawara, Noriko Tsuda, Masataka Nakagawa, Seiji Tomiguchi, Yasuyuki Yamashita
    Annals of Nuclear Medicine.2020; 34(6): 415.     CrossRef
  • Difference in cardiovascular response during orthostatic stress in Parkinson’s disease and multiple system atrophy
    Tomohiko Nakamura, Masashi Suzuki, Masamichi Ueda, Yumiko Harada, Masaaki Hirayama, Masahisa Katsuno
    Journal of Neural Transmission.2020; 127(10): 1377.     CrossRef
  • Striatal dopamine activity and myocardial 123I-metaiodobenzylguanidine uptake in early Parkinson's disease
    Yoon-Sang Oh, Joong-Seok Kim, Sang-Won Yoo, Eo-Jin Hwang, Chul Hyoung Lyoo, Kwang-Soo Lee
    Parkinsonism & Related Disorders.2019; 63: 156.     CrossRef
  • Initial Versus Follow-up Sequential Myocardial 123I-MIBG Scintigraphy to Discriminate Parkinson Disease From Atypical Parkinsonian Syndromes
    Dong-Woo Ryu, Joong-Seok Kim, Jee-Eun Lee, Yoon-Sang Oh, Sang-Won Yoo, Ie Ryung Yoo, Kwang-Soo Lee
    Clinical Nuclear Medicine.2019; 44(4): 282.     CrossRef
  • Cardiac 123I-MIBG planar heart to mediastinum ratios depend on patient size; phantom studies suggest SPECT-CT could improve quantification
    Gemma Roberts, Jim J Lloyd, George S Petrides, John T O’Brien, Alan J Thomas
    Biomedical Physics & Engineering Express.2019; 6(1): 015011.     CrossRef
  • Does sympathetic dysfunction occur before denervation in pure autonomic failure?
    Ling Guo, Murray D. Esler, Carolina Sari, Sarah Phillips, Elisabeth A. Lambert, Nora E. Straznicky, Gavin W. Lambert, Susan J. Corcoran
    Clinical Science.2018; 132(1): 1.     CrossRef
  • Validation of Iodine-131-meta-iodobenzylguanidine cardiac scintigraphy in Parkinsonism: A preliminary study
    Dan Xu, Wenjia Zhu, Li Huo, Shikun Zhu, Fang Li, Han Wang
    Parkinsonism & Related Disorders.2018;[Epub]     CrossRef
  • Extensive Delayed Brain Atrophy after Resuscitation in a Patient with Multiple System Atrophy
    Sazuku Nisitani, Hirofumi Miyoshi, Yoji Katsuoka
    Frontiers in Neurology.2018;[Epub]     CrossRef
  • Optimizing Parkinson’s disease diagnosis: the role of a dual nuclear imaging algorithm
    J. William Langston, Jesse C. Wiley, Michele Tagliati
    npj Parkinson's Disease.2018;[Epub]     CrossRef
  • Diagnostic biomarkers for Parkinson’s disease at a glance: where are we?
    Ilaria Cova, Alberto Priori
    Journal of Neural Transmission.2018; 125(10): 1417.     CrossRef
  • Imaging the Autonomic Nervous System in Parkinson’s Disease
    Karoline Knudsen, Per Borghammer
    Current Neurology and Neuroscience Reports.2018;[Epub]     CrossRef
  • A Review of Dementia with Lewy Bodies' Impact, Diagnostic Criteria and Treatment
    Samuel D. Capouch, Martin R. Farlow, Jared R. Brosch
    Neurology and Therapy.2018; 7(2): 249.     CrossRef
  • The Utility of the Combined Use of 123I-FP-CIT and 123I-MIBG Myocardial Scintigraphy in Differentiating Parkinson’s Disease from Other Parkinsonian Syndromes
    Eiji Matsusue, Yoshio Fujihara, Kenichiro Tanaka, Yuki Aozasa, Manabu Shimoda, Hiroyuki Nakayasu, Kazuhiko Nakamura, Toshihide Ogawa
    Yonago Acta Medica.2018; 61(2): 117.     CrossRef
  • Correction of collimator-dependent differences in the heart-to-mediastinum ratio in 123I-metaiodobenzylguanidine cardiac sympathetic imaging: Determination of conversion equations using point-source imaging
    Yusuke Inoue, Yutaka Abe, Kei Kikuchi, Keiji Matsunaga, Ray Masuda, Kazutoshi Nishiyama
    Journal of Nuclear Cardiology.2017; 24(5): 1725.     CrossRef
  • Normal ‘heart’ in Parkinson's disease: is this a distinct clinical phenotype?
    J.-S. Kim, H.-E. Park, I.-S. Park, Y.-S. Oh, D.-W. Ryu, I.-U. Song, Y.-A. Jung, I. R. Yoo, H.-S. Choi, P. H. Lee, K.-S. Lee
    European Journal of Neurology.2017; 24(2): 349.     CrossRef
  • Diagnosis of dementia with Lewy bodies: can123I-IMP and123I-MIBG scintigraphy yield new core features?
    Fumi Sakamoto, Shinya Shiraishi, Noriko Tsuda, Mamoru Hashimoto, Seiji Tomiguchi, Manabu Ikeda, Yasuyuki Yamashita
    The British Journal of Radiology.2017; 90(1070): 20160156.     CrossRef
  • Imaging Parkinson’s disease below the neck
    Per Borghammer, Karoline Knudsen, Tatyana D. Fedorova, David J. Brooks
    npj Parkinson's Disease.2017;[Epub]     CrossRef
  • The utility of the combination of a SPECT study with [123I]-FP-CIT of dopamine transporters and [123I]-MIBG myocardial scintigraphy in differentiating Parkinson disease from other degenerative parkinsonian syndromes
    Naoto Uyama, Hideki Otsuka, Takayoshi Shinya, Yoichi Otomi, Masafumi Harada, Wataru Sako, Yuishin Izumi, Ryuji Kaji, Yuya Watanabe, Satoru Takashi, Yamato Kunikane
    Nuclear Medicine Communications.2017; 38(6): 487.     CrossRef
  • Cardiac sympathetic denervation and dementia in de novo Parkinson's disease: A 7-year follow-up study
    Mun Hee Choi, Jung Han Yoon, Suk Woo Yong
    Journal of the Neurological Sciences.2017; 381: 291.     CrossRef
  • Cardiovascular autonomic dysfunctions in elderly patients with essential tremor: comparison with healthy controls
    Joong-Seok Kim, Yoon-Sang Oh, Hyung-Eun Park, Si-Hoon Lee, Jeong-Wook Park, In-Uk Song, Jae-Young An, Hun-Jun Park, Byung-Chul Son, Kwang-Soo Lee
    Neurological Sciences.2016; 37(5): 711.     CrossRef
  • Orthostatic hypotension and cardiac sympathetic denervation in Parkinson disease patients with REM sleep behavioral disorder
    Joong-Seok Kim, Hyung-Eun Park, Yoon-Sang Oh, Si-Hoon Lee, Jeong-Wook Park, Byung-chul Son, Kwang-Soo Lee
    Journal of the Neurological Sciences.2016; 362: 59.     CrossRef
  • [123]FP-CIT SPECT scans initially rated as normal became abnormal over time in patients with probable dementia with Lewy bodies
    J. J. van der Zande, J. Booij, P. Scheltens, P. G. H. M. Raijmakers, A. W. Lemstra
    European Journal of Nuclear Medicine and Molecular Imaging.2016; 43(6): 1060.     CrossRef
  • Is dopamine transporter invariably impaired at the time of diagnosis in dementia with Lewy bodies?
    Flavio Nobili, Dario Arnaldi, Silvia Morbelli
    European Journal of Nuclear Medicine and Molecular Imaging.2016; 43(6): 1056.     CrossRef
  • Imaging Systemic Dysfunction in Parkinson’s Disease
    Per Borghammer, Karoline Knudsen, David J. Brooks
    Current Neurology and Neuroscience Reports.2016;[Epub]     CrossRef
  • 123 I‐2β‐carbomethoxy‐3β‐(4‐iodophenyl)‐ N ‐(3‐fluoropropyl) nortropane single photon emission computed tomography and 123 I‐metaiodobenzylguanidine myocardial scintigraphy in differ
    Pietro Tiraboschi, Angelo Corso, Ugo Paolo Guerra, Flavio Nobili, Arnoldo Piccardo, Maria Lucia Calcagni, Duccio Volterrani, Diego Cecchin, Mauro Tettamanti, Luigi Antelmi, Simone Vidale, Leonardo Sacco, Maria Merello, Stefano Stefanini, Anna Micheli, Pao
    Annals of Neurology.2016; 80(3): 368.     CrossRef
  • On the Utility of MIBG SPECT/CT in Evaluating Cardiac Sympathetic Dysfunction in Lewy Body Diseases
    Hayato Odagiri, Toru Baba, Yoshiyuki Nishio, Osamu Iizuka, Minoru Matsuda, Kentaro Inoue, Akio Kikuchi, Takafumi Hasegawa, Masashi Aoki, Atsushi Takeda, Yasuyuki Taki, Etsuro Mori, John Duda
    PLOS ONE.2016; 11(4): e0152746.     CrossRef
  • 123I-MIBG myocardial scintigraphy and neurocirculatory abnormalities in patients with dementia with Lewy bodies and Alzheimer's disease
    Joong-Seok Kim, Hyung-Eun Park, Yoon-Sang Oh, In-Uk Song, Dong-Won Yang, Jeong-Wook Park, Kwang-Soo Lee
    Journal of the Neurological Sciences.2015; 357(1-2): 173.     CrossRef
  • Orthostatic hypotension: managing a difficult problem
    Pearl K Jones, Brett H Shaw, Satish R Raj
    Expert Review of Cardiovascular Therapy.2015; 13(11): 1263.     CrossRef
Nonmotor Symptoms and Subthalamic Deep Brain Stimulation in Parkinson’s Disease
Han-Joon Kim, Beom S. Jeon, Sun Ha Paek
J Mov Disord. 2015;8(2):83-91.   Published online May 31, 2015
DOI: https://doi.org/10.14802/jmd.15010
  • 23,551 View
  • 238 Download
  • 41 Citations
AbstractAbstract PDF
Subthalamic deep brain stimulation (STN DBS) is an established treatment for the motor symptoms in patients with advanced Parkinson’s disease (PD). In addition to improvements in motor symptoms, many studies have reported changes in various nonmotor symptoms (NMSs) after STN DBS in patients with PD. Psychiatric symptoms, including depression, apathy, anxiety, and impulsivity, can worsen or improve depending on the electrical stimulation parameters, the locations of the stimulating contacts within the STN, and changes in medications after surgery. Global cognitive function is not affected by STN DBS, and there is no increase in the incidence of dementia after STN DBS compared to that after medical treatment, although clinically insignificant declines in verbal fluency have been consistently reported. Pain, especially PD-related pain, improves with STN DBS. Evidence regarding the effects of STN DBS on autonomic symptoms and sleep-related problems is limited and remains conflicting. Many symptoms of nonmotor fluctuations, which are occasionally more troublesome than motor fluctuations, improve with STN DBS. Although it is clear that NMSs are not target symptoms for STN DBS, NMSs have a strong influence on the quality of life of patients with PD, and clinicians should thus be aware of these NMSs when deciding whether to perform surgery and should pay attention to changes in these symptoms after STN DBS to ensure the optimal care for patients.

Citations

Citations to this article as recorded by  
  • A Wellness Prescription for Parkinson's: Mid to Late-stage Disease
    Gregory M Pontone, Bradley McDaniels, Adrienne M Keener, Indu Subramanian
    The American Journal of Geriatric Psychiatry.2023;[Epub]     CrossRef
  • Subthalamic Nucleus Stimulation in Parkinson's Disease: 5‐Year Extension Study of a Randomized Trial
    Silje Bjerknes, Mathias Toft, Reidun Brandt, Trine Waage Rygvold, Ane Konglund, Espen Dietrichs, Stein Andersson, Inger Marie Skogseid
    Movement Disorders Clinical Practice.2022; 9(1): 48.     CrossRef
  • Effects of subthalamic deep brain stimulation on non‐motor symptoms of Parkinson's disease: A meta‐analysis
    Zahra Eghlidos, Zahra Rahimian, Gholamreza Vadiee, Soodeh Jahangiri
    Acta Neurologica Scandinavica.2022; 146(2): 115.     CrossRef
  • Nomogram for Predicting Depression Improvement after Deep Brain Stimulation for Parkinson’s Disease
    Bowen Chang, Chen Ni, Jiaming Mei, Chi Xiong, Peng Chen, Manli Jiang, Chaoshi Niu
    Brain Sciences.2022; 12(7): 841.     CrossRef
  • A nigra–subthalamic circuit is involved in acute and chronic pain states
    Cui Yin, Tao Jia, Yiwen Luan, Xue Zhang, Cheng Xiao, Chunyi Zhou
    Pain.2022; 163(10): 1952.     CrossRef
  • A nigro–subthalamo–parabrachial pathway modulates pain-like behaviors
    Tao Jia, Ying-Di Wang, Jing Chen, Xue Zhang, Jun-Li Cao, Cheng Xiao, Chunyi Zhou
    Nature Communications.2022;[Epub]     CrossRef
  • Basal impulses: findings from the last twenty years on impulsivity and reward pathways using deep brain stimulation
    Pavan S. UPADHYAYULA, Robert C. RENNERT, Joel R. MARTIN, John K. YUE, Jason YANG, Eva M. GILLIS-BUCK, Nikki SIDHU, Christopher K. CHEUNG, Anthony T. LEE, Reid R. HOSHIDE, Joseph D. CIACCI
    Journal of Neurosurgical Sciences.2021;[Epub]     CrossRef
  • Pallidal versus subthalamic deep-brain stimulation for meige syndrome: a retrospective study
    Jiayu Liu, Hu Ding, Ke Xu, Ruen Liu, Dongliang Wang, Jia Ouyang, Zhi Liu, Zeyu Miao
    Scientific Reports.2021;[Epub]     CrossRef
  • Eight‐year follow‐up outcome of subthalamic deep brain stimulation for Parkinson’s disease: Maintenance of therapeutic efficacy with a relatively low levodopa dosage and stimulation intensity
    Lulu Jiang, Wanru Chen, Qiyu Guo, Chao Yang, Jing Gu, Wenbiao Xian, Yanmei Liu, Yifan Zheng, Jing Ye, Shaohua Xu, Yu Hu, Lei Wu, Jie Chen, Hao Qian, Xiaoli Fu, Jinlong Liu, Ling Chen
    CNS Neuroscience & Therapeutics.2021; 27(11): 1366.     CrossRef
  • Clinical Impact of Deep Brain Stimulation on the Autonomic System in Patients with Parkinson's Disease
    Gabriele Bellini, Laura A. Best, Una Brechany, Russell Mills, Nicola Pavese
    Movement Disorders Clinical Practice.2020; 7(4): 373.     CrossRef
  • Reversal of hyperactive subthalamic circuits differentially mitigates pain hypersensitivity phenotypes in parkinsonian mice
    Yiwen Luan, Dongliang Tang, Haichuan Wu, Weixin Gu, Yuqing Wu, Jun-Li Cao, Cheng Xiao, Chunyi Zhou
    Proceedings of the National Academy of Sciences.2020; 117(18): 10045.     CrossRef
  • Impulsivity and Compulsivity After Subthalamic Deep Brain Stimulation for Parkinson’s Disease
    Sara Scherrer, Andrew H. Smith, Jaimie Gowatsky, Christina A. Palmese, Joohi Jimenez-Shahed, Brian H. Kopell, Helen S. Mayberg, Martijn Figee
    Frontiers in Behavioral Neuroscience.2020;[Epub]     CrossRef
  • Deep brain stimulation and recordings: Insights into the contributions of subthalamic nucleus in cognition
    Neil M. Drummond, Robert Chen
    NeuroImage.2020; 222: 117300.     CrossRef
  • Bilateral Subthalamic Nucleus Deep Brain Stimulation under General Anesthesia: Literature Review and Single Center Experience
    Hye Ran Park, Yong Hoon Lim, Eun Jin Song, Jae Meen Lee, Kawngwoo Park, Kwang Hyon Park, Woong-Woo Lee, Han-Joon Kim, Beomseok Jeon, Sun Ha Paek
    Journal of Clinical Medicine.2020; 9(9): 3044.     CrossRef
  • Subthalamic deep brain stimulation improves sleep and excessive sweating in Parkinson’s disease
    Silje Bjerknes, Inger Marie Skogseid, Tuva Jin Hauge, Espen Dietrichs, Mathias Toft
    npj Parkinson's Disease.2020;[Epub]     CrossRef
  • Impacto de la estimulación subtalámica a largo plazo sobre la situación cognitiva de los pacientes con enfermedad de Parkinson avanzada
    M. Acera, A. Molano, B. Tijero, G. Bilbao, I. Lambarri, R. Villoria, J. Somme, E. Ruiz de Gopegui, I. Gabilondo, J.C. Gomez-Esteban
    Neurología.2019; 34(9): 573.     CrossRef
  • The Subthalamic Nucleus: Unravelling New Roles and Mechanisms in the Control of Action
    Tora Bonnevie, Kareem A. Zaghloul
    The Neuroscientist.2019; 25(1): 48.     CrossRef
  • Modulation of specific components of sleep disturbances by simultaneous subthalamic and nigral stimulation in Parkinson's disease
    U. Hidding, A. Gulberti, C. Pflug, C. Choe, A. Horn, L. Prilop, H. Braaß, O. Fründt, C. Buhmann, D. Weiss, M. Westphal, A.K. Engel, C. Gerloff, J.A. Köppen, W. Hamel, C.K.E. Moll, M. Pötter-Nerger
    Parkinsonism & Related Disorders.2019; 62: 141.     CrossRef
  • Zona incerta GABAergic neurons integrate prey-related sensory signals and induce an appetitive drive to promote hunting
    Zheng-dong Zhao, Zongming Chen, Xinkuan Xiang, Mengna Hu, Hengchang Xie, Xiaoning Jia, Fang Cai, Yuting Cui, Zijun Chen, Lechen Qian, Jiashu Liu, Congping Shang, Yiqing Yang, Xinyan Ni, Wenzhi Sun, Ji Hu, Peng Cao, Haohong Li, Wei L. Shen
    Nature Neuroscience.2019; 22(6): 921.     CrossRef
  • Long-term impact of subthalamic stimulation on cognitive function in patients with advanced Parkinson's disease
    M. Acera, A. Molano, B. Tijero, G. Bilbao, I. Lambarri, R. Villoria, J. Somme, E. Ruiz de Gopegui, I. Gabilondo, J.C. Gomez-Esteban
    Neurología (English Edition).2019; 34(9): 573.     CrossRef
  • Influencia de la estimulación cerebral profunda en la carga de cuidadores de pacientes con enfermedad de Parkinson
    J.A. Crespo-Burillo, D. Rivero-Celada, A. Saenz-de Cabezón, J. Casado-Pellejero, J. Alberdi-Viñas, R. Alarcia-Alejos
    Neurología.2018; 33(3): 154.     CrossRef
  • Alteration in the Local and Global Functional Connectivity of Resting State Networks in Parkinson’s Disease
    Maryam Ghahremani, Jaejun Yoo, Sun Ju Chung, Kwangsun Yoo, Jong C. Ye, Yong Jeong
    Journal of Movement Disorders.2018; 11(1): 13.     CrossRef
  • Deep brain stimulation for patients with Parkinson's disease: Effect on caregiver burden
    J.A. Crespo-Burillo, D. Rivero-Celada, A. Saenz-de Cabezón, J. Casado-Pellejero, J. Alberdi-Viñas, R. Alarcia-Alejos
    Neurología (English Edition).2018; 33(3): 154.     CrossRef
  • Clinical Markers of Anxiety Subtypes in Parkinson Disease
    Martinus P. G. Broen, A. F. G. Leentjens, J. T. Hinkle, A. J. H. Moonen, M. L. Kuijf, N. M. Fischer, K. Perepezko, A. Bakker, G. M. Pontone
    Journal of Geriatric Psychiatry and Neurology.2018; 31(2): 55.     CrossRef
  • Apathy following Bilateral Deep Brain Stimulation of Subthalamic Nucleus in Parkinson’s Disease: A Meta-Analysis
    Ying Wang, Yongsheng Li, Xiaona Zhang, Anmu Xie
    Parkinson's Disease.2018; 2018: 1.     CrossRef
  • Non-motor Characterization of the Basal Ganglia: Evidence From Human and Non-human Primate Electrophysiology
    Robert S. Eisinger, Morgan E. Urdaneta, Kelly D. Foote, Michael S. Okun, Aysegul Gunduz
    Frontiers in Neuroscience.2018;[Epub]     CrossRef
  • Revealing a novel nociceptive network that links the subthalamic nucleus to pain processing
    Arnaud Pautrat, Marta Rolland, Margaux Barthelemy, Christelle Baunez, Valérie Sinniger, Brigitte Piallat, Marc Savasta, Paul G Overton, Olivier David, Veronique Coizet
    eLife.2018;[Epub]     CrossRef
  • Cerebrospinal fluid protein markers in PD patients after DBS-STN surgery—A retrospective analysis of patients that underwent surgery between 1993 and 2001
    Radu Constantinescu, Kaj Blennow, Lars Rosengren, Barbro Eriksson, Thordis Gudmundsdottir, Yvonne Jansson, Bo Johnels, Annika Renck, Filip Bergquist
    Clinical Neurology and Neurosurgery.2018; 174: 174.     CrossRef
  • Predictors to quality of life improvements after subthalamic stimulation in Parkinson’s disease
    Feng‐Tao Liu, Li‐Qin Lang, Yu‐Jie Yang, Jue Zhao, Rui Feng, Jie Hu, Jian Wang, Jian‐Jun Wu
    Acta Neurologica Scandinavica.2018;[Epub]     CrossRef
  • Apathy associated with neurocognitive disorders: Recent progress and future directions
    Krista L. Lanctôt, Luis Agüera‐Ortiz, Henry Brodaty, Paul T. Francis, Yonas E. Geda, Zahinoor Ismail, Gad A. Marshall, Moyra E. Mortby, Chiadi U. Onyike, Prasad R. Padala, Antonios M. Politis, Paul B. Rosenberg, Emma Siegel, David L. Sultzer, Eleenor H. A
    Alzheimer's & Dementia.2017; 13(1): 84.     CrossRef
  • Can deep brain stimulation be a therapeutic option for Parkinson's disease dementia?
    Han‐Joon Kim, Beomseok Jeon, Jee‐Young Lee, Sun Ha Paek
    Neurology and Clinical Neuroscience.2017; 5(1): 3.     CrossRef
  • The effect of deep brain stimulation on the non-motor symptoms of Parkinson’s disease: a critical review of the current evidence
    Mónica M Kurtis, Thadshani Rajah, Luisa F Delgado, Haidar S Dafsari
    npj Parkinson's Disease.2017;[Epub]     CrossRef
  • Delayed responses of subthalamic nucleus to deep brain stimulation in patients with Parkinson's disease
    Lin Shi, Kai Zhang, Fan-Gang Meng, Guan-Yu Zhu, Ying-Chuan Chen, Jun-Jian Zhou, Zhong-Hai Zhou, Jian-Guo Zhang
    Parkinsonism & Related Disorders.2017; 40: 76.     CrossRef
  • Acute response of non-motor symptoms to subthalamic deep brain stimulation in Parkinson's disease
    Margherita Fabbri, Miguel Coelho, Leonor Correia Guedes, Mario M. Rosa, Daisy Abreu, Nilza Gonçalves, Angelo Antonini, Joaquim J. Ferreira
    Parkinsonism & Related Disorders.2017;[Epub]     CrossRef
  • Deep Brain Stimulation of Hemiparkinsonian Rats with Unipolar and Bipolar Electrodes for up to 6 Weeks: Behavioral Testing of Freely Moving Animals
    Kathrin Badstuebner, Ulrike Gimsa, Immo Weber, Armin Tuchscherer, Jan Gimsa
    Parkinson's Disease.2017; 2017: 1.     CrossRef
  • Current Topics in Deep Brain Stimulation for Parkinson Disease
    Atsushi UMEMURA, Genko OYAMA, Yasushi SHIMO, Madoka NAKAJIMA, Asuka NAKAJIMA, Takayuki JO, Satoko SEKIMOTO, Masanobu ITO, Takumi MITSUHASHI, Nobutaka HATTORI, Hajime ARAI
    Neurologia medico-chirurgica.2016; 56(10): 613.     CrossRef
  • In Parkinson’s disease STN stimulation enhances responsiveness of movement initiation speed to high reward value
    Maja Kojovic, Andrea Higgins, Marjan Jahanshahi
    Neuropsychologia.2016; 89: 273.     CrossRef
  • Restoring Spinal Noradrenergic Inhibitory Tone Attenuates Pain Hypersensitivity in a Rat Model of Parkinson’s Disease
    Lei-Fang Cao, Xiao-Yan Peng, Ya Huang, Bing Wang, Feng-Ming Zhou, Ruo-Xiao Cheng, Li-Hua Chen, Wei-Feng Luo, Tong Liu
    Neural Plasticity.2016; 2016: 1.     CrossRef
  • The KMDS-NATION Study: Korean Movement Disorders Society Multicenter Assessment of Non-Motor Symptoms and Quality of Life in Parkinson's Disease NATION Study Group
    Do-Young Kwon, Seong-Beom Koh, Jae Hyeok Lee, Hee Kyung Park, Han-Joon Kim, Hae-Won Shin, Jinyoung Youn, Kun Woo Park, Sun-Ah Choi, Sang Jin Kim, Seong-Min Choi, Ji-Yun Park, Beom S. Jeon, Ji Young Kim, Sun Ju Chung, Chong Sik Lee, Jeong-Ho Park, Tae-Beom
    Journal of Clinical Neurology.2016; 12(4): 393.     CrossRef
  • Antiparkinsonian Treatment for Depression in Parkinson's Disease: Are Selective Serotonin Reuptake Inhibitors Recommended?
    Philippe De Deurwaerdère, Yuqiang Ding
    Translational Neuroscience and Clinics.2016; 2(2): 138.     CrossRef
  • The Subthalamic Nucleus, Limbic Function, and Impulse Control
    P. Justin Rossi, Aysegul Gunduz, Michael S. Okun
    Neuropsychology Review.2015; 25(4): 398.     CrossRef
Modeling α-Synuclein Propagation with Preformed Fibril Injections
Hyun Kyung Chung, Hoang-Anh Ho, Dayana Pérez-Acuña, Seung-Jae Lee
J Mov Disord. 2019;12(3):139-151.   Published online September 30, 2019
DOI: https://doi.org/10.14802/jmd.19046
Correction in: J Mov Disord 2020;13(1):77
  • 13,287 View
  • 783 Download
  • 39 Citations
AbstractAbstract PDF
The aggregation of α-synuclein (α-syn) has been implicated in the pathogenesis of many neurodegenerative disorders, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). Postmortem analyses of α-syn pathology, especially that of PD, have suggested that aggregates progressively spread from a few discrete locations to wider brain regions. The neuron-to-neuron propagation of α-syn has been suggested to be the underlying mechanism by which aggregates spread throughout the brain. Many cellular and animal models has been created to study cell-to-cell propagation. Recently, it has been shown that a single injection of preformed fibrils (PFFs) made of recombinant α-syn proteins into various tissues and organs of many different animal species results in widespread α-syn pathology in the central nervous system (CNS). These PFF models have been extensively used to study the mechanism by which aggregates spread throughout the brain. Here, we review what we have learned from PFF models, describe the nature of PFFs and the neuropathological features, neurophysiological characteristics, and behavioral outcomes of the models.

Citations

Citations to this article as recorded by  
  • CSF-derived extracellular vesicles from patients with Parkinson’s disease induce symptoms and pathology
    Shay Herman, Ruth Djaldetti, Brit Mollenhauer, Daniel Offen
    Brain.2023; 146(1): 209.     CrossRef
  • Overexpression-Induced α-Synuclein Brain Spreading
    Rita Pinto-Costa, Eugenia Harbachova, Pietro La Vitola, Donato A. Di Monte
    Neurotherapeutics.2023; 20(1): 83.     CrossRef
  • The Role of α-Synuclein in the Regulation of Serotonin System: Physiological and Pathological Features
    Lluis Miquel-Rio, Unai Sarriés-Serrano, Rubén Pavia-Collado, J Javier Meana, Analia Bortolozzi
    Biomedicines.2023; 11(2): 541.     CrossRef
  • α‐Synuclein decoy peptide protects mice against α‐synuclein‐induced memory loss
    Qingyun Guo, Ichiro Kawahata, Wenbin Jia, Haoyang Wang, An Cheng, Yasushi Yabuki, Norifumi Shioda, Kohji Fukunaga
    CNS Neuroscience & Therapeutics.2023; 29(6): 1547.     CrossRef
  • Duodenal alpha‐Synuclein Pathology and Enteric Gliosis in Advanced Parkinson's Disease
    Aron Emmi, Michele Sandre, Francesco Paolo Russo, Giulia Tombesi, Federica Garrì, Marta Campagnolo, Miryam Carecchio, Roberta Biundo, Gaya Spolverato, Veronica Macchi, Edoardo Savarino, Fabio Farinati, Piero Parchi, Andrea Porzionato, Luigi Bubacco, Raffa
    Movement Disorders.2023;[Epub]     CrossRef
  • Retina-to-brain spreading of α-synuclein after intravitreal injection of preformed fibrils
    Dayana Pérez-Acuña, Ka Hyun Rhee, Soo Jean Shin, Jeeyun Ahn, Jee-Young Lee, Seung-Jae Lee
    Acta Neuropathologica Communications.2023;[Epub]     CrossRef
  • DA-9805 protects dopaminergic neurons from endoplasmic reticulum stress and inflammation
    Sora Kang, Ying Piao, Young Cheol Kang, Suyeol Lim, Youngmi Kim Pak
    Biomedicine & Pharmacotherapy.2022; 145: 112389.     CrossRef
  • Endogenous Levels of Alpha-Synuclein Modulate Seeding and Aggregation in Cultured Cells
    Eftychia Vasili, Antonio Dominguez-Meijide, Manuel Flores-León, Mohammed Al-Azzani, Angeliki Kanellidi, Ronald Melki, Leonidas Stefanis, Tiago Fleming Outeiro
    Molecular Neurobiology.2022; 59(2): 1273.     CrossRef
  • Phosphorylation of endogenous α-synuclein induced by extracellular seeds initiates at the pre-synaptic region and spreads to the cell body
    Shiori Awa, Genjiro Suzuki, Masami Masuda-Suzukake, Takashi Nonaka, Minoru Saito, Masato Hasegawa
    Scientific Reports.2022;[Epub]     CrossRef
  • Evidence of Inflammation in Parkinson’s Disease and Its Contribution to Synucleinopathy
    Thuy Thi Lai, Yun Joong Kim, Hyeo-il Ma, Young Eun Kim
    Journal of Movement Disorders.2022; 15(1): 1.     CrossRef
  • α-Synuclein in Parkinson's disease and advances in detection
    Rong Chen, Xuan Gu, Xiaoying Wang
    Clinica Chimica Acta.2022; 529: 76.     CrossRef
  • Neurons with Cat’s Eyes: A Synthetic Strain of α-Synuclein Fibrils Seeding Neuronal Intranuclear Inclusions
    Francesca De Giorgi, Muhammed Bilal Abdul-Shukkoor, Marianna Kashyrina, Leslie-Ann Largitte, Francesco De Nuccio, Brice Kauffmann, Alons Lends, Florent Laferrière, Sébastien Bonhommeau, Dario Domenico Lofrumento, Luc Bousset, Erwan Bezard, Thierry Buffete
    Biomolecules.2022; 12(3): 436.     CrossRef
  • A Novel NOX Inhibitor Treatment Attenuates Parkinson’s Disease-Related Pathology in Mouse Models
    Anurupa A. Ghosh, Dinesh Kumar Verma, Gabriela Cabrera, Kwadwo Ofori, Karina Hernandez-Quijada, Jae-Kwan Kim, Joo Hee Chung, Michael Moore, Sung Hwan Moon, Jong Bok Seo, Yong-Hwan Kim
    International Journal of Molecular Sciences.2022; 23(8): 4262.     CrossRef
  • Do Naturally Occurring Antioxidants Protect Against Neurodegeneration of the Dopaminergic System? A Systematic Revision in Animal Models of Parkinson's Disease
    Carmen Costas, Lilian R.F. Faro
    Current Neuropharmacology.2022; 20(2): 432.     CrossRef
  • NXP031 prevents dopaminergic neuronal loss and oxidative damage in the AAV-WT-α-synuclein mouse model of Parkinson’s disease
    Min Kyung Song, Levi Adams, Joo Hee Lee, Yoon-Seong Kim, Hemant K. Paudel
    PLOS ONE.2022; 17(7): e0272085.     CrossRef
  • Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo
    Rachel E. Lackie, Aline S. de Miranda, Mei Peng Lim, Vladislav Novikov, Nimrod Madrer, Nadun C. Karunatilleke, Benjamin S. Rutledge, Stephanie Tullo, Anne Brickenden, Matthew E. R. Maitland, David Greenberg, Daniel Gallino, Wen Luo, Anoosha Attaran, Irina
    Acta Neuropathologica.2022; 144(5): 881.     CrossRef
  • Nanomedicine in the Face of Parkinson’s Disease: From Drug Delivery Systems to Nanozymes
    Francisco J. Padilla-Godínez, Leonardo I. Ruiz-Ortega, Magdalena Guerra-Crespo
    Cells.2022; 11(21): 3445.     CrossRef
  • Animal Models of Metabolic Disorders in the Study of Neurodegenerative Diseases: An Overview
    Andreza Fabro de Bem, Rachel Krolow, Hémelin Resende Farias, Victória Linden de Rezende, Daniel Pens Gelain, José Cláudio Fonseca Moreira, João Miguel das Neves Duarte, Jade de Oliveira
    Frontiers in Neuroscience.2021;[Epub]     CrossRef
  • Role of Liver Growth Factor (LGF) in Parkinson’s Disease: Molecular Insights and Therapeutic Opportunities
    Efthalia Angelopoulou, Yam Nath Paudel, Christina Piperi
    Molecular Neurobiology.2021; 58(7): 3031.     CrossRef
  • Trans-synaptic spreading of alpha-synuclein pathology through sensory afferents leads to sensory nerve degeneration and neuropathic pain
    Nelson Ferreira, Nádia Pereira Gonçalves, Asad Jan, Nanna Møller Jensen, Amelia van der Laan, Simin Mohseni, Christian Bjerggaard Vægter, Poul Henning Jensen
    Acta Neuropathologica Communications.2021;[Epub]     CrossRef
  • Pharmacological Inhibition of Brain EGFR Activation By a BBB-penetrating Inhibitor, AZD3759, Attenuates α-synuclein Pathology in a Mouse Model of α-Synuclein Propagation
    Omid Tavassoly, Esther del Cid Pellitero, Frederique Larroquette, Eddie Cai, Rhalena A. Thomas, Vincent Soubannier, Wen Luo, Thomas M. Durcan, Edward A. Fon
    Neurotherapeutics.2021; 18(2): 979.     CrossRef
  • The Future of Incretin-Based Approaches for Neurodegenerative Diseases in Older Adults: Which to Choose? A Review of their Potential Efficacy and Suitability
    Christine Girges, Nirosen Vijiaratnam, Dilan Athauda, Grace Auld, Sonia Gandhi, Thomas Foltynie
    Drugs & Aging.2021; 38(5): 355.     CrossRef
  • Prodromal neuroinvasion of pathological α-synuclein in brainstem reticular nuclei and white matter lesions in a model of α-synucleinopathy
    Nelson Ferreira, Mette Richner, Amelia van der Laan, Ida Bergholdt Jul Christiansen, Christian B Vægter, Jens R Nyengaard, Glenda M Halliday, Joachim Weis, Benoit I Giasson, Ian R Mackenzie, Poul H Jensen, Asad Jan
    Brain Communications.2021;[Epub]     CrossRef
  • Impact of the apelin/APJ axis in the pathogenesis of Parkinson’s disease with therapeutic potential
    Efthalia Angelopoulou, Yam Nath Paudel, Anastasia Bougea, Christina Piperi
    Journal of Neuroscience Research.2021; 99(9): 2117.     CrossRef
  • Adenovirus-induced Reactive Astrogliosis Exacerbates the Pathology of Parkinson’s Disease
    Heeyoung An, Hyowon Lee, Seulkee Yang, Woojin Won, C. Justin Lee, Min-Ho Nam
    Experimental Neurobiology.2021; 30(3): 222.     CrossRef
  • Brain iron enrichment attenuates α‐synuclein spreading after injection of preformed fibrils
    Karina Dauer née Joppe, Lars Tatenhorst, Lucas Caldi Gomes, Shuyu Zhang, Mojan Parvaz, Eleonora Carboni, Anna‐Elisa Roser, Hazem El DeBakey, Mathias Bähr, Katarina Vogel‐Mikuš, Chi Wang Ip, Stefan Becker, Markus Zweckstetter, Paul Lingor
    Journal of Neurochemistry.2021; 159(3): 554.     CrossRef
  • Increased oscillatory power in a computational model of the olfactory bulb due to synaptic degeneration
    J. Kendall Berry, Daniel Cox
    Physical Review E.2021;[Epub]     CrossRef
  • Combining Automated Organoid Workflows with Artificial Intelligence‐Based Analyses: Opportunities to Build a New Generation of Interdisciplinary High‐Throughput Screens for Parkinson's Disease and Beyond
    Henrik Renner, Hans R. Schöler, Jan M. Bruder
    Movement Disorders.2021; 36(12): 2745.     CrossRef
  • Is Multiple System Atrophy a Prion-like Disorder?
    Kurt A. Jellinger, Gregor K. Wenning, Nadia Stefanova
    International Journal of Molecular Sciences.2021; 22(18): 10093.     CrossRef
  • Cortical alpha-synuclein preformed fibrils do not affect interval timing in mice
    Qiang Zhang, Hisham Abdelmotilib, Travis Larson, Cameron Keomanivong, Mackenzie Conlon, Georgina M. Aldridge, Nandakumar S. Narayanan
    Neuroscience Letters.2021; 765: 136273.     CrossRef
  • Temporal Evolution of Inflammation and Neurodegeneration With Alpha-Synuclein Propagation in Parkinson's Disease Mouse Model
    Thuy Thi Lai, Yun Joong Kim, Phuong Thi Nguyen, Young Ho Koh, Tinh Thi Nguyen, Hyeo-il Ma, Young Eun Kim
    Frontiers in Integrative Neuroscience.2021;[Epub]     CrossRef
  • The Concept of α-Synuclein Strains and How Different Conformations May Explain Distinct Neurodegenerative Disorders
    Katja Malfertheiner, Nadia Stefanova, Antonio Heras-Garvin
    Frontiers in Neurology.2021;[Epub]     CrossRef
  • A historical review of multiple system atrophy with a critical appraisal of cellular and animal models
    David J. Marmion, Wouter Peelaerts, Jeffrey H. Kordower
    Journal of Neural Transmission.2021; 128(10): 1507.     CrossRef
  • Exploring the Etiological Links behind Neurodegenerative Diseases: Inflammatory Cytokines and Bioactive Kynurenines
    Masaru Tanaka, József Toldi, László Vécsei
    International Journal of Molecular Sciences.2020; 21(7): 2431.     CrossRef
  • Modeling Parkinson’s Disease With the Alpha-Synuclein Protein
    Mónica Gómez-Benito, Noelia Granado, Patricia García-Sanz, Anne Michel, Mireille Dumoulin, Rosario Moratalla
    Frontiers in Pharmacology.2020;[Epub]     CrossRef
  • Enhanced Susceptibility of PINK1 Knockout Rats to α-Synuclein Fibrils
    Rose B. Creed, Matthew S. Goldberg
    Neuroscience.2020; 437: 64.     CrossRef
  • Pathogenic Mutations Differentially Regulate Cell-to-Cell Transmission of α-Synuclein
    Yuan Guan, Xiaofang Zhao, Fengwei Liu, Shuxin Yan, Yalong Wang, Cuilian Du, Xiuyu Cui, Rena Li, Claire Xi Zhang
    Frontiers in Cellular Neuroscience.2020;[Epub]     CrossRef
  • Dopamine, Alpha-Synuclein, and Mitochondrial Dysfunctions in Parkinsonian Eyes
    Alessia Indrieri, Rocco Pizzarelli, Brunella Franco, Elvira De Leonibus
    Frontiers in Neuroscience.2020;[Epub]     CrossRef
  • Classic and evolving animal models in Parkinson's disease
    Tanvi Pingale, Girdhari Lal Gupta
    Pharmacology Biochemistry and Behavior.2020; 199: 173060.     CrossRef
Update on Current Technologies for Deep Brain Stimulation in Parkinson’s Disease
Michelle Paff, Aaron Loh, Can Sarica, Andres M. Lozano, Alfonso Fasano
J Mov Disord. 2020;13(3):185-198.   Published online August 31, 2020
DOI: https://doi.org/10.14802/jmd.20052
  • 15,803 View
  • 646 Download
  • 38 Citations
AbstractAbstract PDF
Deep brain stimulation (DBS) is becoming increasingly central in the treatment of patients with Parkinson’s disease and other movement disorders. Recent developments in DBS lead and implantable pulse generator design provide increased flexibility for programming, potentially improving the therapeutic benefit of stimulation. Directional DBS leads may increase the therapeutic window of stimulation by providing a means of avoiding current spread to structures that might give rise to stimulation-related side effects. Similarly, control of current to individual contacts on a DBS lead allows for shaping of the electric field produced between multiple active contacts. The following review aims to describe the recent developments in DBS system technology and the features of each commercially available DBS system. The advantages of each system are reviewed, and general considerations for choosing the most appropriate system are discussed.

Citations

Citations to this article as recorded by  
  • Long-term motor outcomes of deep brain stimulation of the globus pallidus interna in Parkinson's disease patients: Five-year follow-up
    Yun Su Hwang, Sungyang Jo, Seung Hyun Lee, Nayoung Kim, Mi-Sun Kim, Sang Ryong Jeon, Sun Ju Chung
    Journal of the Neurological Sciences.2023; 444: 120484.     CrossRef
  • Implementing automation in deep brain stimulation: has the time come?
    Marco Bonizzato, Alfonso Fasano
    The Lancet Digital Health.2023; 5(2): e52.     CrossRef
  • Proceedings of the 10th annual deep brain stimulation think tank: Advances in cutting edge technologies, artificial intelligence, neuromodulation, neuroethics, interventional psychiatry, and women in neuromodulation
    Joshua K. Wong, Helen S. Mayberg, Doris D. Wang, R. Mark Richardson, Casey H. Halpern, Lothar Krinke, Mattia Arlotti, Lorenzo Rossi, Alberto Priori, Sara Marceglia, Ro’ee Gilron, James F. Cavanagh, Jack W. Judy, Svjetlana Miocinovic, Annaelle D. Devergnas
    Frontiers in Human Neuroscience.2023;[Epub]     CrossRef
  • Deep brain stimulation: new programming algorithms and teleprogramming
    Renato Puppi Munhoz, Ghadh Albuainain
    Expert Review of Neurotherapeutics.2023; 23(5): 467.     CrossRef
  • Impact of modeled field of view in electroconvulsive therapy current flow simulations
    Alexander Guillen, Christopher C. Abbott, Zhi-De Deng, Yu Huang, Paula Pascoal-Faria, Dennis Q. Truong, Abhishek Datta
    Frontiers in Psychiatry.2023;[Epub]     CrossRef
  • Brain stimulation treatments in epilepsy: Basic mechanisms and clinical advances
    Thomas J. Foutz, Michael Wong
    Biomedical Journal.2022; 45(1): 27.     CrossRef
  • Neurodegenerative disorders management: state-of-art and prospects of nano-biotechnology
    Raj Kumar, Keshaw Ram Aadil, Kunal Mondal, Yogendra Kumar Mishra, David Oupicky, Seeram Ramakrishna, Ajeet Kaushik
    Critical Reviews in Biotechnology.2022; 42(8): 1180.     CrossRef
  • Sleep and circadian rhythms in Parkinson’s disease and preclinical models
    Jeremy Hunt, Elizabeth J. Coulson, Rajendram Rajnarayanan, Henrik Oster, Aleksandar Videnovic, Oliver Rawashdeh
    Molecular Neurodegeneration.2022;[Epub]     CrossRef
  • Jose Delgado: A controversial trailblazer in neuromodulation
    Nicholas D. Lorusso, Uma R. Mohan, Joshua Jacobs
    Artificial Organs.2022; 46(4): 531.     CrossRef
  • Local and distant cortical responses to single pulse intracranial stimulation in the human brain are differentially modulated by specific stimulation parameters
    Angelique C. Paulk, Rina Zelmann, Britni Crocker, Alik S. Widge, Darin D. Dougherty, Emad N. Eskandar, Daniel S. Weisholtz, R. Mark Richardson, G. Rees Cosgrove, Ziv M. Williams, Sydney S. Cash
    Brain Stimulation.2022;[Epub]     CrossRef
  • Proceedings of the Ninth Annual Deep Brain Stimulation Think Tank: Advances in Cutting Edge Technologies, Artificial Intelligence, Neuromodulation, Neuroethics, Pain, Interventional Psychiatry, Epilepsy, and Traumatic Brain Injury
    Joshua K. Wong, Günther Deuschl, Robin Wolke, Hagai Bergman, Muthuraman Muthuraman, Sergiu Groppa, Sameer A. Sheth, Helen M. Bronte-Stewart, Kevin B. Wilkins, Matthew N. Petrucci, Emilia Lambert, Yasmine Kehnemouyi, Philip A. Starr, Simon Little, Juan Ans
    Frontiers in Human Neuroscience.2022;[Epub]     CrossRef
  • Past, Present, and Future of Deep Brain Stimulation: Hardware, Software, Imaging, Physiology and Novel Approaches
    Jessica Frey, Jackson Cagle, Kara A. Johnson, Joshua K. Wong, Justin D. Hilliard, Christopher R. Butson, Michael S. Okun, Coralie de Hemptinne
    Frontiers in Neurology.2022;[Epub]     CrossRef
  • Parkinson’s Disease Management via Wearable Sensors: A Systematic Review
    Huma Mughal, Abdul Rehman Javed, Muhammad Rizwan, Ahmad S. Almadhor, Natalia Kryvinska
    IEEE Access.2022; 10: 35219.     CrossRef
  • Conversion to Hybrid Deep Brain Stimulation System to Enable Multi‐Contact Fractionation Can be Therapeutic
    Disep I. Ojukwu, Allan R. Wang, Traci S. Hornbeck, Erika A. Lim, Jennifer Sharrard, Rohit Dhall, Vivek P. Buch, Casey H. Halpern
    Movement Disorders.2022; 37(6): 1321.     CrossRef
  • Developments in Deep Brain Stimulators for Successful Aging Towards Smart Devices—An Overview
    Angelito A. Silverio, Lean Angelo A. Silverio
    Frontiers in Aging.2022;[Epub]     CrossRef
  • Single-interface bioelectronic medicines—concept, clinical applications and preclinical data
    Cristian Sevcencu
    Journal of Neural Engineering.2022; 19(3): 031001.     CrossRef
  • Current Steering Using Multiple Independent Current Control Deep Brain Stimulation Technology Results in Distinct Neurophysiological Responses in Parkinson’s Disease Patients
    Jana Peeters, Alexandra Boogers, Tine Van Bogaert, Robin Gransier, Jan Wouters, Bart Nuttin, Myles Mc Laughlin
    Frontiers in Human Neuroscience.2022;[Epub]     CrossRef
  • Managing Intractable Symptoms of Parkinson's Disease: A Nonsurgical Approach Employing Infralow Frequency Neuromodulation
    Stella B. Legarda, P. Andreas Michas-Martin, Dana McDermott
    Frontiers in Human Neuroscience.2022;[Epub]     CrossRef
  • Directional Deep Brain Stimulation in the Treatment of Parkinson's Disease
    Akash Mishra, Ritesh A Ramdhani
    Neurology.2022; 18(1): 64.     CrossRef
  • Approach to the Treatment of Pediatric Dystonia
    Carolina Gorodetsky, Alfonso Fasano
    Dystonia.2022;[Epub]     CrossRef
  • CRISPR and iPSCs: Recent Developments and Future Perspectives in Neurodegenerative Disease Modelling, Research, and Therapeutics
    Tirthankar Sen, Rajkumar P. Thummer
    Neurotoxicity Research.2022; 40(5): 1597.     CrossRef
  • Encoding type, medication, and deep brain stimulation differentially affect memory-guided sequential reaching movements in Parkinson's disease
    Fabian J. David, Yessenia M. Rivera, Tara K. Entezar, Rishabh Arora, Quentin H. Drane, Miranda J. Munoz, Joshua M. Rosenow, Sepehr B. Sani, Gian D. Pal, Leonard Verhagen-Metman, Daniel M. Corcos
    Frontiers in Neurology.2022;[Epub]     CrossRef
  • Remote programming for subthalamic deep brain stimulation in Parkinson's disease
    Si Chen, Shu-jun Xu, Wei-guo Li, Teng Chen, Chao Li, Shuo Xu, Ning Yang, Yi-ming Liu
    Frontiers in Neurology.2022;[Epub]     CrossRef
  • Longevity of Deep Brain Stimulation Batteries; a Global Survey of Neurosurgeons and Neurologists
    Marwan Hariz, Gun‐Marie Hariz, Patric Blomstedt
    Movement Disorders.2021; 36(5): 1273.     CrossRef
  • Basic Tips: How Do I Start Programming Deep Brain Stimulation in Parkinson Disease Patients?
    Carolina Gorodetsky, Alfonso Fasano
    Movement Disorders Clinical Practice.2021; 8(4): 639.     CrossRef
  • Deep brain stimulation: Challenges at the tissue‐electrode interface and current solutions
    Emily Kolaya, Bonnie L. Firestein
    Biotechnology Progress.2021;[Epub]     CrossRef
  • An Update on Medical and Surgical Treatments of Parkinson’s Disease
    Dipali Nemade, Thyagarajan Subramanian, Vikram Shivkumar
    Aging and disease.2021; 12(4): 1021.     CrossRef
  • Experimental Characterization of Ferroelectric Capacitor Circuits for the Realization of Simply Designed Electroceuticals
    Yves Olsommer, Frank R. Ihmig
    Electronic Materials.2021; 2(3): 299.     CrossRef
  • Flexible vs. standard subthalamic stimulation in Parkinson disease: A double-blind proof-of-concept cross-over trial
    Derrick Soh, Ricardo Maciel, Musleh Algarni, Karlo Lizarraga, Aaron Loh, Jürgen Germann, Gavin Elias, Alexandre Boutet, Renato P. Munhoz, Suneil K. Kalia, Mojgan Hodaie, Andres M. Lozano, Alfonso Fasano
    Parkinsonism & Related Disorders.2021; 89: 93.     CrossRef
  • Telemedicine and Deep brain stimulation - Current practices and recommendations
    Vibhash D. Sharma, Delaram Safarpour, Shyamal H. Mehta, Nora Vanegas-Arroyave, Daniel Weiss, Jeffrey W. Cooney, Zoltan Mari, Alfonso Fasano
    Parkinsonism & Related Disorders.2021; 89: 199.     CrossRef
  • Subspace-based predictive control of Parkinson’s disease: A model-based study
    Mahboubeh Ahmadipour, Mojtaba Barkhordari-Yazdi, Saeid R. Seydnejad
    Neural Networks.2021; 142: 680.     CrossRef
  • Advances in Triboelectric Nanogenerators for Self‐Powered Regenerative Medicine
    Samira Parandeh, Niloofar Etemadi, Mahshid Kharaziha, Guorui Chen, Ardo Nashalian, Xiao Xiao, Jun Chen
    Advanced Functional Materials.2021; 31(47): 2105169.     CrossRef
  • Implantable Pulse Generators for Deep Brain Stimulation: Challenges, Complications, and Strategies for Practicality and Longevity
    Can Sarica, Christian Iorio-Morin, David H. Aguirre-Padilla, Ahmed Najjar, Michelle Paff, Anton Fomenko, Kazuaki Yamamoto, Ajmal Zemmar, Nir Lipsman, George M. Ibrahim, Clement Hamani, Mojgan Hodaie, Andres M. Lozano, Renato P. Munhoz, Alfonso Fasano, Sun
    Frontiers in Human Neuroscience.2021;[Epub]     CrossRef
  • Microstimulation Is a Promising Approach in Achieving Better Lead Placement in Subthalamic Nucleus Deep Brain Stimulation Surgery
    Lin Shi, Shiying Fan, Tianshuo Yuan, Huaying Fang, Jie Zheng, Zunyu Xiao, Yu Diao, Guanyu Zhu, Quan Zhang, Huanguang Liu, Hua Zhang, Fangang Meng, Jianguo Zhang, Anchao Yang
    Frontiers in Neurology.2021;[Epub]     CrossRef
  • Revisiting brain stimulation in Parkinson’s disease
    Carola A. Haas
    Science.2021; 374(6564): 153.     CrossRef
  • A New Implantable Closed-Loop Clinical Neural Interface: First Application in Parkinson’s Disease
    Mattia Arlotti, Matteo Colombo, Andrea Bonfanti, Tomasz Mandat, Michele Maria Lanotte, Elena Pirola, Linda Borellini, Paolo Rampini, Roberto Eleopra, Sara Rinaldo, Luigi Romito, Marcus L. F. Janssen, Alberto Priori, Sara Marceglia
    Frontiers in Neuroscience.2021;[Epub]     CrossRef
  • Update on Parkinson's Disease Therapy
    Rebecca M Gilbert
    Neurology.2021; 17(2): 92.     CrossRef
  • Deep Brain Stimulation for Parkinson's Disease: Currents Status and Emerging Concepts
    PareshK Doshi, Deepak Das
    Neurology India.2020; 68(8): 179.     CrossRef
JMD : Journal of Movement Disorders
© The Korean Movement Disorder Society.