KMDS
E-submission
Most cited
- Page Path
- HOME > Browse Articles > Most cited
Review Articles
- Functional Neuroanatomy for Posture and Gait Control
- Kaoru Takakusaki
- J Mov Disord. 2017;10(1):1-17. Published online January 18, 2017
- DOI: https://doi.org/10.14802/jmd.16062
- 65,535 View
- 4,392 Download
- 415 Citations
-
Abstract
PDF - Here we argue functional neuroanatomy for posture- gait control. Multi-sensory information such as somatosensory, visual and vestibular sensation act on various areas of the brain so that adaptable posture- gait control can be achieved. Automatic process of gait, which is steady-state stepping movements associating with postural reflexes including headeye coordination accompanied by appropriate alignment of body segments and optimal level of postural muscle tone, is mediated by the descending pathways from the brainstem to the spinal cord. Particularly, reticulospinal pathways arising from the lateral part of the mesopontine tegmentum and spinal locomotor network contribute to this process. On the other hand, walking in unfamiliar circumstance requires cognitive process of postural control, which depends on knowledges of self-body, such as body schema and body motion in space. The cognitive information is produced at the temporoparietal association cortex, and is fundamental to sustention of vertical posture and construction of motor programs. The programs in the motor cortical areas run to execute anticipatory postural adjustment that is optimal for achievement of goal-directed movements. The basal ganglia and cerebellum may affect both the automatic and cognitive processes of posturegait control through reciprocal connections with the brainstem and cerebral cortex, respectively. Consequently, impairments in cognitive function by damages in the cerebral cortex, basal ganglia and cerebellum may disturb posture-gait control, resulting in falling.
-
Citations
Citations to this article as recorded by
- Correlations between plantar pressure and postural balance in healthy subjects and their comparison according to gender and limb dominance: A cross-sectional descriptive study
Gamze Arin-Bal, Ayse Livanelioglu, Alberto Leardini, Claudio Belvedere
Gait & Posture.2024; 108: 124. CrossRef - Young adults who improve performance during dual-task walking show more flexible reallocation of cognitive resources: a mobile brain-body imaging (MoBI) study
Eleni Patelaki, John J Foxe, Kevin A Mazurek, Edward G Freedman
Cerebral Cortex.2023; 33(6): 2573. CrossRef - Midfrontal theta dynamics index the monitoring of postural stability
Mitchel Stokkermans, Teodoro Solis-Escalante, Michael X Cohen, Vivian Weerdesteyn
Cerebral Cortex.2023; 33(7): 3454. CrossRef - The Instrumented Stand and Walk (ISAW) test to predict falls in older men
Fay B. Horak, Amy Laird, Patricia Carlson-Kuhta, Melanie Abrahamson, Martina Mancini, Eric S. Orwoll, Jodi A. Lapidus, Vrutangkumar V. Shah
GeroScience.2023; 45(2): 823. CrossRef - Turning and multitask gait unmask gait disturbance in mild‐to‐moderate multiple sclerosis: Underlying specific cortical thinning and connecting fibers damage
Qingmeng Chen, Takaaki Hattori, Hiroshi Tomisato, Masahiro Ohara, Kosei Hirata, Takanori Yokota
Human Brain Mapping.2023; 44(3): 1193. CrossRef - Neurophysiological mechanisms of gait disturbance in advanced Parkinson's disease patients
Kaoru Takakusaki, Mirai Takahashi, Tomohiro Noguchi, Ryosuke Chiba
Neurology and Clinical Neuroscience.2023; 11(4): 201. CrossRef - Altered brain function in patients with vestibular migraine: a study on resting state functional connectivity
Zhengwei Chen, Liangqun Rong, Lijie Xiao, Quan Wang, Yueji Liu, Cunxin Lin, Jianing Wang, Haiyan Liu, Xiu-e Wei
Neuroradiology.2023; 65(3): 579. CrossRef - Assessment of balance in people with mild traumatic brain injury using a balance systems model approach
Kody R. Campbell, Kathleen T. Scanlan, Jennifer L. Wilhelm, Barbara H. Brumbach, Natalie C. Pettigrew, Akira Neilson, Lucy Parrington, Laurie A. King
Gait & Posture.2023; 100: 107. CrossRef - Relationship between lower limb muscle activity and cortical activation among elderly people during walking: Effects of fast speed and cognitive dual task
Jinuk Kim, Jungsoo Lee, Gihyoun Lee, Won Hyuk Chang, Myoung-Hwan Ko, Woo-Kyoung Yoo, Gyu-Ha Ryu, Yun-Hee Kim
Frontiers in Aging Neuroscience.2023;[Epub] CrossRef - Mental states and personality based on real-time physical activity and facial expression recognition
Yating Huang, Dengyue Zhai, Jingze Song, Xuanheng Rao, Xiao Sun, Jin Tang
Frontiers in Psychiatry.2023;[Epub] CrossRef - Sensorimotor recalibration of postural control strategies occurs after whole body vibration
Isotta Rigoni, Giulio Degano, Mahmoud Hassan, Antonio Fratini
Scientific Reports.2023;[Epub] CrossRef - A neuroergonomic approach to assessing motor performance in stroke patients using fNIRS and behavioral data
Lingguo Bu, Jing Qu, Lei Zhao, Yanjie Zhang, Yonghui Wang
Applied Ergonomics.2023; 109: 103979. CrossRef - Case report: A novel approach of closed-loop brain stimulation combined with robot gait training in post-stroke gait disturbance
Atsushi Shima, Tomoaki Miyake, Kazuki Tanaka, Akari Ogawa, Erika Omae, Yui Nagamori, Yusuke Miyata, Koji Ohata, Takakuni Maki, Yumie Ono, Tatsuya Mima, Ryosuke Takahashi, Satoko Koganemaru
Frontiers in Human Neuroscience.2023;[Epub] CrossRef - Cognitive and emotional factors influence specific domains of postural control in individuals with moderate-to-severe Parkinson’s disease
Claudia Eunice Neves de Oliveira, Daniel Boari Coelho, Caroline Ribeiro de Souza, Alana Xavier Batista, Raquel Marquesini, Acácio Moreira-Neto, Carla Silva-Batista, Adriana Tanigawa Bitiati, Luis Augusto Teixeira, Andrea Cristina de Lima-Pardini
Gait & Posture.2023; 101: 66. CrossRef - Developmental changes in straight gait in childhood
Saori Miyagishima, Hiroki Mani, Yui Sato, Takahiro Inoue, Tadayoshi Asaka, Naoki Kozuka, Dimitrios Sokratis Komaris
PLOS ONE.2023; 18(2): e0281037. CrossRef - Case report: Backward gait training combined with gait-synchronized cerebellar transcranial alternating current stimulation in progressive supranuclear palsy
Atsushi Shima, Kazuki Tanaka, Akari Ogawa, Erika Omae, Tomoaki Miyake, Yui Nagamori, Yusuke Miyata, Koji Ohata, Yumie Ono, Tatsuya Mima, Ryosuke Takahashi, Satoko Koganemaru
Frontiers in Human Neuroscience.2023;[Epub] CrossRef - Cerebellar Transcranial Direct Current Stimulation Modulates Anticipatory Postural Adjustments in Healthy Adults
Haian Mao, Wenwu Xiao, Zengming Hao, Shengjun Wen, Huaichun Yang, Fahad Sultan, Chuhuai Wang
The Cerebellum.2023;[Epub] CrossRef - Model of Gait Control in Parkinson’s Disease and Prediction of Robotic Assistance
Clémence Vandamme, Virginie Otlet, Renaud Ronsse, Frédéric Crevecoeur
IEEE Transactions on Neural Systems and Rehabilitation Engineering.2023; 31: 1374. CrossRef - Sex-specific differences in resting-state functional brain activity in pediatric concussion
Bhanu Sharma, Cameron Nowikow, Carol DeMatteo, Michael D. Noseworthy, Brian W. Timmons
Scientific Reports.2023;[Epub] CrossRef - Pain and Parkinson's disease: Current mechanism and management updates
Frederic J. F. Viseux, Arnaud Delval, Martin Simoneau, Luc Defebvre
European Journal of Pain.2023; 27(5): 553. CrossRef - Increased Effective Connectivity of the Left Parietal Lobe During Walking Tasks in Parkinson’s Disease
Yue Wang, Ningbo Yu, Jiewei Lu, Xinyuan Zhang, Jin Wang, Zhilin Shu, Yuanyuan Cheng, Zhizhong Zhu, Yang Yu, Peipei Liu, Jianda Han, Jialing Wu
Journal of Parkinson's Disease.2023; 13(2): 165. CrossRef - Imagined Timed Up and Go test (iTUG) in people with Parkinson’s Disease: test-retest reliability and validity
Marcos Moreno-Verdú, María del Rosario Ferreira-Sánchez, Patricia Martín-Casas, María Ángeles Atín-Arratibel
Disability and Rehabilitation.2023; : 1. CrossRef - Cortical oscillations and interareal synchronization as a preparatory activity for postural response
Kimiya Fujio, Hiroki Obata, Kenta Takeda, Noritaka Kawashima
European Journal of Neuroscience.2023; 57(9): 1516. CrossRef - Effects of wearable visual cueing on gait pattern and stability in patients with Parkinson’s disease
Wei Zhang, Yun Han, Yuanyuan Shi, Shilei Yan, Wenjing Song, Guiyun Cui, Jie Xiang
Frontiers in Neurology.2023;[Epub] CrossRef - Modulating arousal to overcome gait impairments in Parkinson’s disease: how the noradrenergic system may act as a double-edged sword
Anouk Tosserams, Bastiaan R. Bloem, Kaylena A. Ehgoetz Martens, Rick C. Helmich, Roy P. C. Kessels, James M. Shine, Natasha L. Taylor, Gabriel Wainstein, Simon J. G. Lewis, Jorik Nonnekes
Translational Neurodegeneration.2023;[Epub] CrossRef - Contrôle central de l’équilibre et prévention des chutes : impact sur la rééducation
A.P. Yelnik
Bulletin de l'Académie Nationale de Médecine.2023; 207(5): 649. CrossRef - Variability of the lower limb symmetry index associated with the gait parameters in the overweight adult population with flatfoot: a case-control study
Israel Casado-Hernández, Ricardo Becerro-de-Bengoa-Vallejo, Marta Losa-Iglesias, Juan Gómez-Salgado, Daniel López-López, Javier Bayod
Frontiers in Bioengineering and Biotechnology.2023;[Epub] CrossRef - Influence of wearing complete dentures on control of head position during walking in edentulous older adults
Kento Shimizu, Hiroyuki Suzuki, Naoya Isoyama, Yuiko Yanagihara, Shunsuke Minakuchi
Journal of Oral Rehabilitation.2023; 50(10): 1012. CrossRef - Cortical thickness is related to cognitive-motor automaticity and attention allocation in individuals with Alzheimer’s disease: a regions of interest study
Jason K. Longhurst, Karthik R. Sreenivasan, Jemma Kim, Jeffrey L. Cummings, Samantha E. John, Brach Poston, Dietmar Cordes, John V. Rider, Merrill R. Landers
Experimental Brain Research.2023; 241(6): 1489. CrossRef - Structural-Functional Correlates of Response to Pedunculopontine Stimulation in a Randomized Clinical Trial for Axial Symptoms of Parkinson’s Disease
Sorin Breit, Luka Milosevic, Georgios Naros, Idil Cebi, Daniel Weiss, Alireza Gharabaghi
Journal of Parkinson's Disease.2023; 13(4): 563. CrossRef - Interrelation between functional decline and dementia: The potential role of balance assessment
Francesca Biasin, Chiara Ceolin, Silvia Celli, Camilla Terziotti, Cecilia Raffaelli, Cristiano Bontempi, Maria Devita, Marina De Rui, Giuseppe Sergi, Alessandra Coin
Human Movement Science.2023; 89: 103095. CrossRef - Trend Change Analysis as a New Tool to Complement
the Evaluation of Human Body Balance
in the Time and Frequency Domains
Piotr Wodarski
Journal of Human Kinetics.2023;[Epub] CrossRef - Neural underpinnings of freezing-related dynamic balance control in people with Parkinson's disease
Bauke W. Dijkstra, Moran Gilat, Nicholas D'Cruz, Demi Zoetewei, Alice Nieuwboer
Parkinsonism & Related Disorders.2023; 112: 105444. CrossRef - Electrocortical Dynamics of Usual Walking and the Planning to Step over Obstacles in Parkinson’s Disease
Rodrigo Vitório, Ellen Lirani-Silva, Diego Orcioli-Silva, Victor Spiandor Beretta, Anderson Souza Oliveira, Lilian Teresa Bucken Gobbi
Sensors.2023; 23(10): 4866. CrossRef - Mental fatigue does not affect static balance under both single and dual task conditions in young adults
Abubakar Tijjani Salihu, Jibrin Sammani Usman, Keith D. Hill, Maryam Zoghi, Shapour Jaberzadeh
Experimental Brain Research.2023; 241(7): 1769. CrossRef - Contribution of neural circuits tested by transcranial magnetic stimulation in corticomotor control of low back muscle: a systematic review
Mikaël Desmons, Michael Theberge, Catherine Mercier, Hugo Massé-Alarie
Frontiers in Neuroscience.2023;[Epub] CrossRef - Predicting the fatigue in Parkinson's disease using inertial sensor gait data and clinical characteristics
Hui Wang, Binbin Hu, Juan Huang, Lin Chen, Min Yuan, Xingfu Tian, Ting Shi, Jiahao Zhao, Wei Huang
Frontiers in Neurology.2023;[Epub] CrossRef - Basal Ganglia and Brainstem Located Cerebral Microbleeds Contributed to Gait Impairment in Patients with Cerebral Small Vessel Disease
He-Jiao Mao, Jiang-Xia Zhang, Wen-Cheng Zhu, Hao Zhang, Xiang-Min Fan, Fei Han, Jun Ni, Li-Xin Zhou, Ming Yao, Feng Tian, Ning Su, Yi-Cheng Zhu
Journal of Alzheimer's Disease.2023; 94(3): 1005. CrossRef - Facilitating or disturbing? An investigation about the effects of auditory frequencies on prefrontal cortex activation and postural sway
Valeria Belluscio, Giulia Cartocci, Tommaso Terbojevich, Paolo Di Feo, Bianca Maria Serena Inguscio, Marco Ferrari, Valentina Quaresima, Giuseppe Vannozzi
Frontiers in Neuroscience.2023;[Epub] CrossRef - Functional connectome predicting individual gait function and its relationship with molecular architecture in Parkinson's disease
Haoting Wu, Chenqing Wu, Jianmei Qin, Cheng Zhou, Sijia Tan, Xiaojie DuanMu, Xiaojun Guan, Xueqin Bai, Tao Guo, Jingjing Wu, Jingwen Chen, Jiaqi Wen, Zhengye Cao, Ting Gao, Luyan Gu, Peiyu Huang, Baorong Zhang, Xiaojun Xu, Minming Zhang
Neurobiology of Disease.2023; 184: 106216. CrossRef - Behavioral decomposition reveals rich encoding structure employed across neocortex in rats
Bartul Mimica, Tuçe Tombaz, Claudia Battistin, Jingyi Guo Fuglstad, Benjamin A. Dunn, Jonathan R. Whitlock
Nature Communications.2023;[Epub] CrossRef - Efficacy of Dual‐Task Training in Patients with Parkinson's Disease: A Systematic Review with Meta‐Analysis
Héctor García‐López, María de los Ángeles Castillo‐Pintor, Adelaida María Castro‐Sánchez, Inmaculada Carmen Lara‐Palomo, Esteban Obrero‐Gaitán, Irene Cortés‐Pérez
Movement Disorders Clinical Practice.2023; 10(9): 1268. CrossRef - Artificial Intelligence Distinguishes Pathological Gait: The Analysis of Markerless Motion Capture Gait Data Acquired by an iOS Application (TDPT-GT)
Chifumi Iseki, Tatsuya Hayasaka, Hyota Yanagawa, Yuta Komoriya, Toshiyuki Kondo, Masayuki Hoshi, Tadanori Fukami, Yoshiyuki Kobayashi, Shigeo Ueda, Kaneyuki Kawamae, Masatsune Ishikawa, Shigeki Yamada, Yukihiko Aoyagi, Yasuyuki Ohta
Sensors.2023; 23(13): 6217. CrossRef - Transcranial direct current stimulation suggests not improving postural control during adapted tandem position in people with Parkinson's disease: A pilot study
Beatriz Regina Legutke, Lilian Teresa Bucken Gobbi, Diego Orcioli-Silva, Paulo Cezar Rocha dos Santos, Gabriel Antonio Gazziero Moraca, Rodrigo Vitório, Victor Spiandor Beretta
Behavioural Brain Research.2023; 452: 114581. CrossRef - Postural stability and plantar pressure parameters in healthy subjects: variability, correlation analysis and differences under open and closed eye conditions
P. De Blasiis, P. Caravaggi, A. Fullin, A. Leardini, A. Lucariello, A. Perna, G. Guerra, A. De Luca
Frontiers in Bioengineering and Biotechnology.2023;[Epub] CrossRef - The temporal neurovascular coupling response remains intact during sinusoidal hypotensive and hypertensive challenges
Joel S Burma, Selina Rattana, Ibukunoluwa K Oni, Andrew P Lapointe, Jeff F Dunn, Jonathan D Smirl
Physiological Measurement.2023; 44(7): 074002. CrossRef - The generation mechanisms of gait impairment in Parkinson’s disease and corresponding animal models
Yue Wu, Yezhong Tang, Guangzhan Fang
Chinese Science Bulletin.2023; 68(23): 3043. CrossRef - Human upper extremity motor cortex activity shows distinct oscillatory signatures for stereotyped arm and leg movements
Clara Kwon Starkweather, Melanie A. Morrison, Maria Yaroshinsky, Kenneth Louie, Jannine Balakid, Kara Presbrey, Philip A. Starr, Doris D. Wang
Frontiers in Human Neuroscience.2023;[Epub] CrossRef - Discrete cortical control during quiet stance revealed by desynchronization and rebound of beta oscillations
Akihiro Nakamura, Ryota Miura, Yasuyuki Suzuki, Pietro Morasso, Taishin Nomura
Neuroscience Letters.2023; 814: 137443. CrossRef - Comparison of the effects of rhythmic vibrotactile stimulations and rhythmic auditory stimulations on Parkinson's disease patients’ gait variability: a pilot study
Alexis Lheureux, Thierry Lejeune, Ivan Doncev, Alix Jeanne, Gaëtan Stoquart
Acta Neurologica Belgica.2023;[Epub] CrossRef - Soy sauce and vanilla odors improve balance ability in children
Junichi Inatomi, Kiwa Yasuoka, Hideaki Takebayashi, Yutaka Yano, Satoko Kataoka, Masahiro Yamaguchi
Journal of Sensory Studies.2023;[Epub] CrossRef - Brain activities for Open Intelligence : Application of Brain Science for Behavior Adaptation
Shingo Shimoda
Journal of the Robotics Society of Japan.2023; 41(7): 591. CrossRef - In Silico Neuroprotective Effects of Specific Rheum palmatum Metabolites on Parkinson’s Disease Targets
Patrick Jay B. Garcia, Steven Kuan-Hua Huang, Kathlia A. De Castro-Cruz, Rhoda B. Leron, Po-Wei Tsai
International Journal of Molecular Sciences.2023; 24(18): 13929. CrossRef - Effect of COVID-19 on Maintaining Balance in Highly Skilled Handball Players
Emilio Fernández-Rodríguez, Tomasz Niźnikowski, Oscar Romero Ramos, Logan Markwell
Polish Journal of Sport and Tourism.2023; 30(3): 18. CrossRef - Injury of the Vestibulocerebellar Tract and Signs of Ataxia in Patients with Cerebellar Stroke
Sang-Seok Yeo, Seung-Min Nam, In-Hee Cho
Journal of Clinical Medicine.2023; 12(21): 6877. CrossRef - Analysis of abnormal posture in patients with Parkinson's disease using a computational model considering muscle tones
Yuichiro Omura, Hiroki Togo, Kohei Kaminishi, Tetsuya Hasegawa, Ryosuke Chiba, Arito Yozu, Kaoru Takakusaki, Mitsunari Abe, Yuji Takahashi, Takashi Hanakawa, Jun Ota
Frontiers in Computational Neuroscience.2023;[Epub] CrossRef - Functional near-infrared spectroscopy in the assessment of rehabilitation efficacy of virtual reality products for people with cognitive disorders
Jing Qu, Yanjie Zhang, Lingguo Bu
International Journal of Industrial Ergonomics.2023; 97: 103500. CrossRef - Effect of dual-task interaction combining postural and visual perturbations on cortical activity and postural control ability
Ryoki Nishimoto, Sayaka Fujiwara, Yumiko Kutoku, Toru Ogata, Masahito Mihara
NeuroImage.2023; 280: 120352. CrossRef - Tango-therapy vs physical exercise in older people with dementia; a randomized controlled trial
Lucía Bracco, Arrate Pinto-Carral, Linda Hillaert, France Mourey
BMC Geriatrics.2023;[Epub] CrossRef - Circuits and Biomarkers of the Central Nervous System Relating to Astronaut Performance: Summary Report for a NASA-Sponsored Technical Interchange Meeting
Joshua S. Alwood, Ajitkumar P. Mulavara, Janani Iyer, Siddhita D. Mhatre, Susanna Rosi, Mark Shelhamer, Catherine Davis, Christopher W. Jones, Xiao Wen Mao, Rajeev I. Desai, Alexandra M. Whitmire, Thomas J. Williams
Life.2023; 13(9): 1852. CrossRef - Objective Physical Function in the Alzheimer’s Disease Continuum: Association with Cerebrospinal Fluid Biomarkers in the ALBION Study
Stefanos N. Sampatakakis, Eirini Mamalaki, Eva Ntanasi, Faidra Kalligerou, Ioannis Liampas, Mary Yannakoulia, Antonios N. Gargalionis, Nikolaos Scarmeas
International Journal of Molecular Sciences.2023; 24(18): 14079. CrossRef - Differential spatiotemporal gait effects with frequency and dopaminergic modulation in STN-DBS
Ritesh A. Ramdhani, Jeremy Watts, Myriam Kline, Toni Fitzpatrick, Martin Niethammer, Anahita Khojandi
Frontiers in Aging Neuroscience.2023;[Epub] CrossRef - Physical activity and sport practice to improve balance control of visually impaired individuals: a narrative review with future perspectives
Giuditta Carretti, Mirko Manetti, Mirca Marini
Frontiers in Sports and Active Living.2023;[Epub] CrossRef - Regional activity and effective connectivity within the frontoparietal network during precision walking with visual cueing: an fNIRS study
Duc Trung Le, Masato Tsuyuhara, Hiroki Kuwamura, Kento Kitano, Thu Dang Nguyen, Thuan Duc Nguyen, Naoto Fujita, Tatsunori Watanabe, Hisao Nishijo, Masahito Mihara, Susumu Urakawa
Cerebral Cortex.2023; 33(22): 11157. CrossRef - Effects of dual-task training on chronic ankle instability: a systematic review and meta-analysis
Lu Wang, Ge Yu, Yaping Chen
BMC Musculoskeletal Disorders.2023;[Epub] CrossRef - Changes in vestibular-related responses to combined noisy galvanic vestibular stimulation and cerebellar transcranial direct current stimulation
Tsubasa Mitsutake, Hisato Nakazono, Tomoyuki Shiozaki, Daisuke Fujita, Maiko Sakamoto
Experimental Brain Research.2023;[Epub] CrossRef - Fluctuations in Upper and Lower Body Movement during Walking in Normal Pressure Hydrocephalus and Parkinson’s Disease Assessed by Motion Capture with a Smartphone Application, TDPT-GT
Chifumi Iseki, Shou Suzuki, Tadanori Fukami, Shigeki Yamada, Tatsuya Hayasaka, Toshiyuki Kondo, Masayuki Hoshi, Shigeo Ueda, Yoshiyuki Kobayashi, Masatsune Ishikawa, Shigenori Kanno, Kyoko Suzuki, Yukihiko Aoyagi, Yasuyuki Ohta
Sensors.2023; 23(22): 9263. CrossRef - Multisensory Conflict Impairs Cortico-Muscular Network Connectivity and Postural Stability: Insights from Partial Directed Coherence Analysis
Guozheng Wang, Yi Yang, Kangli Dong, Anke Hua, Jian Wang, Jun Liu
Neuroscience Bulletin.2023;[Epub] CrossRef - Separated center-of-pressure measurements reveal new characteristics of reduced anticipatory postural adjustments during gait initiation in patients with Parkinson’s disease
Ryo Onuma, Tadashi Masuda, Fumihiko Hoshi, Tadamitsu Matsuda, Tomoko Sakai, Atsushi Okawa, Tetsuya Jinno
Physiotherapy Theory and Practice.2022; 38(13): 2544. CrossRef - Kyphosis and bizarre patterns impair spontaneous gait performance in end-of-life mice with Alzheimer's disease pathology while gait is preserved in normal aging
Lidia Castillo-Mariqueo, Lydia Giménez-Llort
Neuroscience Letters.2022; 767: 136280. CrossRef - Brain network topology and future development of freezing of gait in Parkinson’s disease: a longitudinal study
Nannan Li, Du Lei, Jiaxin Peng, Xueling Suo, Junying Li, Liren Duan, Chaolan Chen, Qiyong Gong, Rong Peng
Journal of Neurology.2022; 269(5): 2503. CrossRef - Changes of cerebral network activity after invasive stimulation of the mesencephalic locomotor region in a rat stroke model
Stefanie D. Krämer, Michael K. Schuhmann, Fabian Schadt, Ina Israel, Samuel Samnick, Jens Volkmann, Felix Fluri
Experimental Neurology.2022; 347: 113884. CrossRef - Neuroticism and Extraversion Are Related to Changes in Postural Stability During Anatomically-Related Cognitive Tasks
Christopher I. Higginson, Marisa Valenti, Karlie Ibrahim, Brian A. Knarr, Rob Ryan, Jill S. Higginson
Journal of Motor Behavior.2022; 54(4): 401. CrossRef - Wide-Field Calcium Imaging of Dynamic Cortical Networks during Locomotion
Sarah L West, Justin D Aronson, Laurentiu S Popa, Kathryn D Feller, Russell E Carter, William M Chiesl, Morgan L Gerhart, Aditya C Shekhar, Leila Ghanbari, Suhasa B Kodandaramaiah, Timothy J Ebner
Cerebral Cortex.2022; 32(12): 2668. CrossRef - Longitudinal Relation Between Structural Network Efficiency, Cognition, and Gait in Cerebral Small Vessel Disease
Mengfei Cai, Mina A Jacob, David G Norris, Frank-Erik de Leeuw, Anil M Tuladhar, Lewis A Lipsitz
The Journals of Gerontology: Series A.2022; 77(3): 554. CrossRef - Presence Hallucinations during Locomotion in Patients with Parkinson's Disease
Jevita Potheegadoo, Herberto Dhanis, Judit Horvath, Pierre R. Burkhard, Olaf Blanke
Movement Disorders Clinical Practice.2022; 9(1): 127. CrossRef - Whole-body vibration exercise and training increase regional CBF in mild cognitive impairment with enhanced cognitive function
Ikuo Odano, Fumio Maeyatsu, Mami Asari, Sayaka Yamaguchi, Tsukasa Miura, Yasuyuki Taki
Annals of Nuclear Medicine.2022; 36(1): 82. CrossRef - Visuomotor errors drive step length and step time adaptation during ‘virtual’ split-belt walking: the effects of reinforcement feedback
Sumire Sato, Ashley Cui, Julia T. Choi
Experimental Brain Research.2022; 240(2): 511. CrossRef - Influence of controlled masticatory muscle activity on dynamic reactive balance
Cagla Fadillioglu, Lisa Kanus, Felix Möhler, Steffen Ringhof, Hans J. Schindler, Thorsten Stein, Daniel Hellmann
Journal of Oral Rehabilitation.2022; 49(3): 327. CrossRef - Discussion of Research Priorities for Gait Disorders in Parkinson's Disease
Nicolaas I. Bohnen, Rui M. Costa, William T. Dauer, Stewart A. Factor, Nir Giladi, Mark Hallett, Simon J.G. Lewis, Alice Nieuwboer, John G. Nutt, Kaoru Takakusaki, Un Jung Kang, Serge Przedborski, Stella M. Papa
Movement Disorders.2022; 37(2): 253. CrossRef - Analysis of the Stability of the Body in a Standing Position When Shooting at a Stationary Target―A Randomized Controlled Trial
Marlena Krawczyk-Suszek, Blanka Martowska, Rafał Sapuła
Sensors.2022; 22(1): 368. CrossRef - Gaps and roadmap of novel neuromodulation targets for treatment of gait in Parkinson’s disease
Rubens Gisbert Cury, Nicola Pavese, Tipu Z. Aziz, Joachim K. Krauss, Elena Moro
npj Parkinson's Disease.2022;[Epub] CrossRef - The Influence of Aging on the Functional Connectivity of the Human Basal Ganglia
Clara Rodriguez-Sabate, Ingrid Morales, Manuel Rodriguez
Frontiers in Aging Neuroscience.2022;[Epub] CrossRef - Effects of task prioritization on a postural-motor task in early-stage Parkinson’s disease: EEG connectivity and clinical implication
Cheng-Ya Huang, Liang-Chi Chen, Ruey-Meei Wu, Ing-Shiou Hwang
GeroScience.2022; 44(4): 2061. CrossRef - Effect of cognitive task complexity on dual task postural stability: a systematic review and meta-analysis
Abubakar Tijjani Salihu, Keith D. Hill, Shapour Jaberzadeh
Experimental Brain Research.2022; 240(3): 703. CrossRef - Targeting Sensory and Motor Integration for Recovery of Movement After CNS Injury
Ahmet S. Asan, James R. McIntosh, Jason B. Carmel
Frontiers in Neuroscience.2022;[Epub] CrossRef - Increased prefrontal activity during usual walking in aging
I. Hoang, L. Paire-Ficout, R. Derollepot, S. Perrey, H. Devos, M. Ranchet
International Journal of Psychophysiology.2022; 174: 9. CrossRef - Effects of sling exercise therapy on post-stroke walking impairment: a systematic review and meta-analysis
Junzi Long, Yasu Zhang, Xiaomin Liu, Xiaoqin Jin
International Journal of Rehabilitation Research.2022; 45(1): 12. CrossRef - Electromyographic responses to unexpected Achilles tendon vibration-induced perturbations during standing in young and older people
Anastasia Papavasileiou, Lida Mademli, Vassilia Hatzitaki, Dimitrios A. Patikas
Experimental Brain Research.2022; 240(4): 1017. CrossRef - Do physical activity, cardiorespiratory fitness, and subcortical brain structures explain reduced walking performance in older adults with multiple sclerosis?
Jessica F. Baird, Gary R. Cutter, Robert W. Motl
Multiple Sclerosis and Related Disorders.2022; 60: 103702. CrossRef - Gait and posture are correlated domains in Parkinson’s disease
Thaisy Moraes Costa, Lucas Simieli, Felipe Marrese Bersotti, Luis Mochizuki, Fabio Augusto Barbieri, Daniel Boari Coelho
Neuroscience Letters.2022; 775: 136537. CrossRef - Why Should Constant Stimulation of Saccular Afferents Modify the Posture and Gait of Patients with Bilateral Vestibular Dysfunction? The Saccular Substitution Hypothesis
Ian S. Curthoys, Paul F. Smith, Angel Ramos de Miguel
Journal of Clinical Medicine.2022; 11(4): 1132. CrossRef - A Neural Controller Model Considering the Vestibulospinal Tract in Human Postural Control
Yuichiro Omura, Kohei Kaminishi, Ryosuke Chiba, Kaoru Takakusaki, Jun Ota
Frontiers in Computational Neuroscience.2022;[Epub] CrossRef - Fear of Falling Does Not Influence Dual-Task Gait Costs in People with Parkinson’s Disease: A Cross-Sectional Study
Tino Prell, Manuela Uhlig, Steffen Derlien, Walter Maetzler, Hannah M. Zipprich
Sensors.2022; 22(5): 2029. CrossRef - Dynamics of cortical and corticomuscular connectivity during planning and execution of visually guided steps in humans
Meaghan E Spedden, Mikkel M Beck, Timothy O West, Simon F Farmer, Jens B Nielsen, Jesper Lundbye-Jensen
Cerebral Cortex.2022; 33(2): 258. CrossRef - Combined Subthalamic and Nigral Stimulation Modulates Temporal Gait Coordination and Cortical Gait-Network Activity in Parkinson’s Disease
Jonas R. Wagner, Miriam Schaper, Wolfgang Hamel, Manfred Westphal, Christian Gerloff, Andreas K. Engel, Christian K. E. Moll, Alessandro Gulberti, Monika Pötter-Nerger
Frontiers in Human Neuroscience.2022;[Epub] CrossRef - Variability of Postural Stability and Plantar Pressure Parameters in Healthy Subjects Evaluated by a Novel Pressure Plate
Allegra Fullin, Paolo Caravaggi, Pietro Picerno, Massimiliano Mosca, Silvio Caravelli, Antonio De Luca, Angela Lucariello, Paolo De Blasiis
International Journal of Environmental Research and Public Health.2022; 19(5): 2913. CrossRef - How Does the Central Nervous System for Posture and Locomotion Cope With Damage-Induced Neural Asymmetry?
Didier Le Ray, Mathias Guayasamin
Frontiers in Systems Neuroscience.2022;[Epub] CrossRef - Rodent models for gait network disorders in Parkinson's disease – a translational perspective
Nikolaus Wenger, Arend Vogt, Matej Skrobot, Elisa L. Garulli, Burce Kabaoglu, Christina Salchow-Hömmen, Thomas Schauer, Daniel Kroneberg, Michael K. Schuhmann, Chi Wang Ip, Christoph Harms, Matthias Endres, Ioannis U. Isaias, Philip Tovote, Robert Blum
Experimental Neurology.2022; 352: 114011. CrossRef - Transcutaneous spinal stimulation alters cortical and subcortical activation patterns during mimicked-standing: A proof-of-concept fMRI study
Gerome A. Manson, Darryn A. Atkinson, Zhaoyue Shi, Jony Sheynin, Christof Karmonik, Rachel L. Markley, Dimitry G. Sayenko
Neuroimage: Reports.2022; 2(2): 100090. CrossRef - Differential Relationships Between Brain Structure and Dual Task Walking in Young and Older Adults
Kathleen E. Hupfeld, Justin M. Geraghty, Heather R. McGregor, C. J. Hass, Ofer Pasternak, Rachael D. Seidler
Frontiers in Aging Neuroscience.2022;[Epub] CrossRef - What Is the Brainstem Control of Locomotion?
Farwa Ali, Eduardo Benarroch
Neurology.2022; 98(11): 446. CrossRef - The emerging postural instability phenotype in idiopathic Parkinson disease
Frank M. Skidmore, William S. Monroe, Christopher P. Hurt, Anthony P. Nicholas, Adam Gerstenecker, Thomas Anthony, Leon Jololian, Gary Cutter, Adil Bashir, Thomas Denny, David Standaert, Elizabeth A. Disbrow
npj Parkinson's Disease.2022;[Epub] CrossRef - Brain Activation During Active Balancing and Its Behavioral Relevance in Younger and Older Adults: A Functional Near-Infrared Spectroscopy (fNIRS) Study
Nico Lehmann, Yves-Alain Kuhn, Martin Keller, Norman Aye, Fabian Herold, Bogdan Draganski, Wolfgang Taube, Marco Taubert
Frontiers in Aging Neuroscience.2022;[Epub] CrossRef - Influence of Controlled Stomatognathic Motor Activity on Sway, Control and Stability of the Center of Mass During Dynamic Steady-State Balance—An Uncontrolled Manifold Analysis
Cagla Fadillioglu, Lisa Kanus, Felix Möhler, Steffen Ringhof, Daniel Hellmann, Thorsten Stein
Frontiers in Human Neuroscience.2022;[Epub] CrossRef - Frequency‐dependent modulation of neural oscillations across the gait cycle
Mingqi Zhao, Gaia Bonassi, Jessica Samogin, Gaia Amaranta Taberna, Elisa Pelosin, Alice Nieuwboer, Laura Avanzino, Dante Mantini
Human Brain Mapping.2022; 43(11): 3404. CrossRef - Gait subgroups among older adults with chronic pain differ in cerebellum and basal ganglia gray matter volumes
Ania L. Lipat, David J. Clark, Chris J. Hass, Yenisel Cruz-Almeida
Experimental Gerontology.2022; 163: 111773. CrossRef - Restorative Action of Vitamin D3 on Motor Dysfunction Through Enhancement of Neurotrophins and Antioxidant Expression in the Striatum
S.K.V. Manjari, Shuvadeep Maity, R. Poornima, Suk-Yu Yau, K. Vaishali, David Stellwagen, Pragya Komal
Neuroscience.2022; 492: 67. CrossRef - Consensus Paper: Ataxic Gait
Pierre Cabaraux, Sunil K. Agrawal, Huaying Cai, Rocco Salvatore Calabro, Carlo Casali, Loic Damm, Sarah Doss, Christophe Habas, Anja K. E. Horn, Winfried Ilg, Elan D. Louis, Hiroshi Mitoma, Vito Monaco, Maria Petracca, Alberto Ranavolo, Ashwini K. Rao, Se
The Cerebellum.2022; 22(3): 394. CrossRef - Body Representation in Patients with Severe Spinal Cord Injury: A Pilot Study on the Promising Role of Powered Exoskeleton for Gait Training
Maria Grazia Maggio, Antonino Naro, Rosaria De Luca, Desiree Latella, Tina Balletta, Lory Caccamo, Giovanni Pioggia, Daniele Bruschetta, Rocco Salvatore Calabrò
Journal of Personalized Medicine.2022; 12(4): 619. CrossRef - Parkinson’s Disease Symptoms Associated with Developing On-State Axial Symptoms Early after Subthalamic Deep Brain Stimulation
Gustavo Fernández-Pajarín, Ángel Sesar, José Luis Relova, Begoña Ares, Isabel Jiménez, Miguel Gelabert-González, Eduardo Arán, Alfonso Castro
Diagnostics.2022; 12(4): 1001. CrossRef - Glycation modulates glutamatergic signaling and exacerbates Parkinson’s disease-like phenotypes
Ana Chegão, Mariana Guarda, Bruno M. Alexandre, Liana Shvachiy, Mariana Temido-Ferreira, Inês Marques-Morgado, Bárbara Fernandes Gomes, Rune Matthiesen, Luísa V. Lopes, Pedro R. Florindo, Ricardo A. Gomes, Patrícia Gomes-Alves, Joana E. Coelho, Tiago Flem
npj Parkinson's Disease.2022;[Epub] CrossRef - The Association Between Gait Speed and Sleep Problems Among Chinese Adults Aged 50 and Greater
Lili Wang, Benxu Zou
Frontiers in Neuroscience.2022;[Epub] CrossRef - Effect of optokinetic virtual reality scenes on a sitting-to-stand movement
Akkradate Siriphorn, Chachane Jarudej, Nuttapong Ochaklin, Sarunyou Nuttawanlop, Theerapan Prasertteerapong
Human Movement Science.2022; 83: 102956. CrossRef - Neurophysiological mechanisms of gait disturbance in advanced Parkinson's disease patients
Kaoru Takakusaki, Mirai Takahashi, Tomohiro Noguchi, Ryosuke Chiba
Neurology and Clinical Neuroscience.2022;[Epub] CrossRef - Is Balance Control Affected by Sleep Deprivation? A Systematic Review of the Impact of Sleep on the Control of Balance
Guilherme Silva Umemura, Fabianne Furtado, Fabia Camile dos Santos, Bruno da Silva Brandão Gonçalves, Arturo Forner-Cordero
Frontiers in Neuroscience.2022;[Epub] CrossRef - Troubleshooting Gait Disturbances in Parkinson’s Disease With Deep Brain Stimulation
Nicoló G. Pozzi, Chiara Palmisano, Martin M. Reich, Philip Capetian, Claudio Pacchetti, Jens Volkmann, Ioannis U. Isaias
Frontiers in Human Neuroscience.2022;[Epub] CrossRef - The functional and structural neural correlates of dynamic balance impairment and recovery in persons with acquired brain injury
Katherin Joubran, Simona Bar-Haim, Lior Shmuelof
Scientific Reports.2022;[Epub] CrossRef - Motor imagery in amyotrophic lateral Sclerosis: An fMRI study of postural control
Malek Abidi, Pierre-Francois Pradat, Nicolas Termoz, Annabelle Couillandre, Peter Bede, Giovanni de Marco
NeuroImage: Clinical.2022; 35: 103051. CrossRef - Brain and muscle activation patterns during postural control affect static postural control
Ken Kumai, Yumi Ikeda, Katsuya Sakai, Keisuke Goto, Kenji Morikawa, Keiichirou Shibata
Gait & Posture.2022; 96: 102. CrossRef - Decoding neural activity preceding balance loss during standing with a lower-limb exoskeleton using an interpretable deep learning model
Akshay Sujatha Ravindran, Christopher A Malaya, Isaac John, Gerard E Francisco, Charles Layne, Jose L Contreras-Vidal
Journal of Neural Engineering.2022; 19(3): 036015. CrossRef - Free-living gait does not differentiate chronic mTBI patients compared to healthy controls
Dylan Powell, Alan Godfrey, Lucy Parrington, Kody R. Campbell, Laurie A. King, Sam Stuart
Journal of NeuroEngineering and Rehabilitation.2022;[Epub] CrossRef - The “Hand as Foot” teaching method in anatomy of the inner ear
Meng Xu, Feifei Zhao, Yanlin Chen, Xiaobo Zhu
Asian Journal of Surgery.2022; 45(11): 2451. CrossRef - Assessing Neurokinematic and Neuromuscular Connectivity During Walking Using Mobile Brain-Body Imaging
Mingqi Zhao, Gaia Bonassi, Jessica Samogin, Gaia Amaranta Taberna, Camillo Porcaro, Elisa Pelosin, Laura Avanzino, Dante Mantini
Frontiers in Neuroscience.2022;[Epub] CrossRef - Stabilometric Biofeedback Training in Cognitive and Affective Function Improvement. Contribution of the Russian Scientific School. Part II
O. M. Bazanova, A. V. Kovaleva
Human Physiology.2022; 48(3): 271. CrossRef - Gait analysis under the lens of statistical physics
Massimiliano Zanin, Felipe Olivares, Irene Pulido-Valdeolivas, Estrella Rausell, David Gomez-Andres
Computational and Structural Biotechnology Journal.2022; 20: 3257. CrossRef - Role of primary motor cortex in gait: automatic-voluntary dissociation seen in paretic leg of a patient who had a stroke
Masanori Nagaoka, Yasuhiro Kumakura, Katsuyuki Inaba, Akira Ebihara, Miyu Usui
BMJ Neurology Open.2022; 4(1): e000275. CrossRef - Reliability and Validity of Mini-Balance Evaluation System Test in Type 2 Diabetic Patients with Peripheral Neuropathy
Sitt Nyein Phyu, Punnee Peungsuwan, Rungthip Puntumetakul, Uraiwan Chatchawan
International Journal of Environmental Research and Public Health.2022; 19(11): 6944. CrossRef - Gray Matter Abnormalities in Myotonic Dystrophy Type 1: A Voxel-Wise Meta-Analysis
Qirui Jiang, Junyu Lin, Chunyu Li, Yanbing Hou, Huifang Shang
Frontiers in Neurology.2022;[Epub] CrossRef - Association of Cervical Vestibular-Evoked Myogenic Potentials (VEMP) and Postural Instability in Patients with Parkinson’s Disease: A Cross-Sectional Study
Archana Gaur, Ravichandran Rajamanickam, Chennappan Chinnathambi, Divya Selvaraju, Varatharajan Sakthivadivel
Annals of Neurosciences.2022; 29(2-3): 137. CrossRef - Neurodegenerative and Cerebrovascular Brain Pathologies Are Differentially Associated With Declining Grip Strength and Gait In Older Adults
Shahram Oveisgharan, Lei Yu, Tianhao Wang, Julie A Schneider, David A Bennett, Aron S Buchman, Lewis A Lipsitz
The Journals of Gerontology: Series A.2022;[Epub] CrossRef - Resting state functional networks predict different aspects of postural control in Parkinson’s disease
Anjanibhargavi Ragothaman, Martina Mancini, John G. Nutt, Damien A. Fair, Oscar Miranda-Dominguez, Fay B. Horak
Gait & Posture.2022; 97: 122. CrossRef - Cumulative additional information does not improve the neuromuscular control during postural responses to perturbations in postural instability/gait disorders subtype of Parkinson's disease
Victor Spiandor Beretta, Paulo Cezar Rocha Santos, Diego Orcioli-Silva, Diego Alejandro Rojas Jaimes, Marcelo Pinto Pereira, Fabio Augusto Barbieri, Lilian Teresa Bucken Gobbi
Experimental Gerontology.2022; 166: 111892. CrossRef - Relation between Cortical Activation and Effort during Robot-Mediated Walking in Healthy People: A Functional Near-Infrared Spectroscopy Neuroimaging Study (fNIRS)
Julien Bonnal, Fanny Monnet, Ba-Thien Le, Ophélie Pila, Anne-Gaëlle Grosmaire, Canan Ozsancak, Christophe Duret, Pascal Auzou
Sensors.2022; 22(15): 5542. CrossRef - Association of Genetic Variant Linked to Hemochromatosis With Brain Magnetic Resonance Imaging Measures of Iron and Movement Disorders
Robert Loughnan, Jonathan Ahern, Cherisse Tompkins, Clare E. Palmer, John Iversen, Wesley K. Thompson, Ole Andreassen, Terry Jernigan, Leo Sugrue, Anders Dale, Mary E. T. Boyle, Chun Chieh Fan
JAMA Neurology.2022; 79(9): 919. CrossRef - Muscle Strength and Balance as Mediators in the Association between Physical Activity and Health-Related Quality of Life in Community-Dwelling Older Adults
Marcelo de Maio Nascimento, Bruna R. Gouveia, Élvio Rúbio Gouveia, Pedro Campos, Adilson Marques, Andreas Ihle
Journal of Clinical Medicine.2022; 11(16): 4857. CrossRef - Spinal cord stimulation therapy for patients with Parkinson’s disease and gait problems (STEP-PD): study protocol for an exploratory, double-blind, randomised, placebo-controlled feasibility trial
Victor S Hvingelby, Miriam Højholt Terkelsen, Erik L Johnsen, Mette Møller, Erik Hvid Danielsen, Tove Henriksen, Andreas Nørgaard Glud, Yen Tai, Anne Sofie Møller Andersen, Kaare Meier, Per Borghammer, Elena Moro, Jens Christian Hedemann Sørensen, Nicola
BMJ Neurology Open.2022; 4(2): e000333. CrossRef - Adaptations of postural sway dynamics and cortical response to unstable stance with stroboscopic vision in older adults
Yi-Ying Tsai, Yi-Ching Chen, Chen-Guang Zhao, Ing-Shiou Hwang
Frontiers in Physiology.2022;[Epub] CrossRef - Blood pressure changes impact corticospinal integrity and downstream gait and balance control
Elizabeth A. Coon, Anna M. Castillo, Timothy G. Lesnick, Sheelakumari Raghavan, Michelle M. Mielke, Robert I. Reid, B. Gwen Windham, Ronald C. Petersen, Clifford R. Jack, Jonathan Graff-Radford, Prashanthi Vemuri
Neurobiology of Aging.2022; 120: 60. CrossRef - Mobile Brain Imaging to Examine Task-Related Cortical Correlates of Reactive Balance: A Systematic Review
Rudri Purohit, Tanvi Bhatt
Brain Sciences.2022; 12(11): 1487. CrossRef - Transcranial direct current stimulation for balance rehabilitation in neurological disorders: A systematic review and meta-analysis
Victor Spiandor Beretta, Paulo Cezar Rocha Santos, Diego Orcioli-Silva, Vinicius Cavassano Zampier, Rodrigo Vitório, Lilian Teresa Bucken Gobbi
Ageing Research Reviews.2022; 81: 101736. CrossRef - Freezing of gait, gait initiation, and gait automaticity share a similar neural substrate in Parkinson's disease
Acácio Moreira-Neto, Carlos Ugrinowitsch, Daniel Boari Coelho, Andrea Cristina de Lima-Pardini, Egberto Reis Barbosa, Luis Augusto Teixeira, Edson Amaro, Fay B. Horak, Martina Mancini, Mariana Penteado Nucci, Carla Silva-Batista
Human Movement Science.2022; 86: 103018. CrossRef - Association between Backward Walking and Cognition in Parkinson Disease: A Systematic Review
Mathias Baptiste Correno, Clint Hansen, Matthias Chardon, Tracy Milane, Edoardo Bianchini, Nicolas Vuillerme
International Journal of Environmental Research and Public Health.2022; 19(19): 12810. CrossRef - The Effect of Dual-Task Motor-Cognitive Training in Adults with Neurological Diseases Who Are at Risk of Falling
Barbara Spanò, Massimo De Tollis, Sara Taglieri, Alice Manzo, Claudia Ricci, Maria G. Lombardi, Lorenzo Polidori, Ivo A. Griffini, Marta Aloisi, Vincenzo Vinicola, Rita Formisano, Carlo Caltagirone, Roberta Annicchiarico
Brain Sciences.2022; 12(9): 1207. CrossRef - Connecting real-world digital mobility assessment to clinical outcomes for regulatory and clinical endorsement–the Mobilise-D study protocol
A. Stefanie Mikolaizak, Lynn Rochester, Walter Maetzler, Basil Sharrack, Heleen Demeyer, Claudia Mazzà, Brian Caulfield, Judith Garcia-Aymerich, Beatrix Vereijken, Valdo Arnera, Ram Miller, Paolo Piraino, Nadir Ammour, Mark Forrest Gordon, Thierry Trooste
PLOS ONE.2022; 17(10): e0269615. CrossRef - Toxicity evaluation induced by single and 28-days repeated exposure of withametelin and daturaolone in Sprague Dawley rats
Muhammad Waleed Baig, Muhammad Majid, Bakht Nasir, Syed Shams ul Hassan, Simona Bungau, Ihsan-ul Haq
Frontiers in Pharmacology.2022;[Epub] CrossRef - Cognitive Function and Postural Control Strategies in Relation to Disease Progression in Patients with Parkinson’s Disease
Monika Zawadka-Kunikowska, Jacek J. Klawe, Małgorzata Tafil-Klawe, Monika Bejtka, Łukasz Rzepiński, Mirosława Cieślicka
International Journal of Environmental Research and Public Health.2022; 19(19): 12694. CrossRef - Effect of sports background on the visual and vestibular signal processing abilities of athletes
F. Zsarnoczky-Dulhazi, A. Hegedus, P. Soldos, L. Trzaskoma, B. Kopper
Science & Sports.2022; 37(8): 798.e1. CrossRef - Abnormal neural oscillations during gait and dual-task in Parkinson’s disease
Rachel O. Nwogo, Stefan Kammermeier, Arun Singh
Frontiers in Systems Neuroscience.2022;[Epub] CrossRef - Effects of different virtual reality technology driven dual-tasking paradigms on posture and saccadic eye movements in healthy older adults
Yu Imaoka, Andri Flury, Laura Hauri, Eling D. de Bruin
Scientific Reports.2022;[Epub] CrossRef - Principles of gait encoding in the subthalamic nucleus of people with Parkinson’s disease
Yohann Thenaisie, Kyuhwa Lee, Charlotte Moerman, Stefano Scafa, Andrea Gálvez, Elvira Pirondini, Morgane Burri, Jimmy Ravier, Alessandro Puiatti, Ettore Accolla, Benoit Wicki, André Zacharia, Mayte Castro Jiménez, Julien F. Bally, Grégoire Courtine, Jocel
Science Translational Medicine.2022;[Epub] CrossRef - Glutamatergic pedunculopontine tegmental neurons control wakefulness and locomotion via distinct axonal projections
Daniel Kroeger, Jack Thundercliffe, Alex Phung, Roberto De Luca, Carolyn Geraci, Samuel Bragg, Kayleen J McCafferty, Sathyajit S Bandaru, Elda Arrigoni, Thomas E Scammell
Sleep.2022;[Epub] CrossRef - Exploring Mediation Effects of Gait Speed, Body Balance, and Falls in the Relationship between Physical Activity and Health-Related Quality of Life in Vulnerable Older Adults
Marcelo de Maio Nascimento, Élvio Rúbio Gouveia, Bruna R. Gouveia, Adilson Marques, Cíntia França, Duarte L. Freitas, Pedro Campos, Andreas Ihle
International Journal of Environmental Research and Public Health.2022; 19(21): 14135. CrossRef - Fronto-parietal cortex activation during walking in patients with Parkinson's disease adopting different postural strategies
Xinyuan Zhang, Yue Wang, Jiewei Lu, Jin Wang, Zhilin Shu, Yuanyuan Cheng, Zhizhong Zhu, PeiPei Liu, Yang Yu, Ningbo Yu, Jianda Han, Jialing Wu
Frontiers in Neurology.2022;[Epub] CrossRef - Perioperative Brain Function Monitoring with Electroencephalography in Horses Anesthetized with Multimodal Balanced Anesthetic Protocol Subjected to Surgeries
Carla Murillo, Hsin-Yi Weng, Ann B. Weil, Matthias Kreuzer, Jeff C. Ko
Animals.2022; 12(20): 2851. CrossRef - Prediction of the gait function using the nigrostriatal and corticoreticulospinal tracts of the affected hemisphere in a cerebral infarct: A diffusion tensor imaging study
Sung Ho Jang, Sang Seok Yeo, Min Jye Cho
Medicine.2022; 101(39): e30788. CrossRef - The Romberg's sign: from walking in the dark to tests on the force plate
Anastasia I. Mezenchuk, Oleg V. Kubryak
Almanac of Clinical Medicine.2022; 50(5): 335. CrossRef - Role of Cervical Spinal Magnetic Stimulation in Improving Posture and Functional Ambulation of Patients with Relapsing Remitting Multiple Sclerosis
Shereen I. Fawaz, Shin-Ichi Izumi, Soha M. Hamada, Abir A. Omara, Ghada O. Wassef, Heba Gamal Saber, Sherihan M. Salama, Cristina Fonte
Rehabilitation Research and Practice.2022; 2022: 1. CrossRef - The brain-body disconnect: A somatic sensory basis for trauma-related disorders
Breanne E. Kearney, Ruth A. Lanius
Frontiers in Neuroscience.2022;[Epub] CrossRef - Dual-task walking improvement with enhanced kinesthetic awareness in Parkinson’s disease with mild gait impairment: EEG connectivity and clinical implication
Cheng-Ya Huang, Yu-An Chen, Ruey-Meei Wu, Ing-Shiou Hwang
Frontiers in Aging Neuroscience.2022;[Epub] CrossRef - Trends in vestibular pathology: persistent postural perceptual dizziness (PPPD)
Daniela Cîrpaciu, Vlad Andrei Budu, Cristina-Maria Goanţă
ORL.ro.2022; 4(57): 14. CrossRef - Biomechanical and Sensory Feedback Regularize the Behavior of Different Locomotor Central Pattern Generators
Kaiyu Deng, Alexander J. Hunt, Nicholas S. Szczecinski, Matthew C. Tresch, Hillel J. Chiel, C. J. Heckman, Roger D. Quinn
Biomimetics.2022; 7(4): 226. CrossRef - Phase-dependent modulation of the vestibular–cerebellar network via combined alternating current stimulation influences human locomotion and posture
Hisato Nakazono, Takanori Taniguchi, Tsubasa Mitsutake, Akinori Takeda, Emi Yamada, Katsuya Ogata
Frontiers in Neuroscience.2022;[Epub] CrossRef - Gait Recovery Characteristic According to the Injury Aspect of Descending Motor Pathway in a Chronic Stroke Patient: a Case Study
Sang Seok Yeo
The Journal of Korean Physical Therapy.2022; 34(6): 326. CrossRef - Cortico-Subthalamic Field Potentials Support Classification of the Natural Gait Cycle in Parkinson’s Disease and Reveal Individualized Spectral Signatures
Kenneth H. Louie, Ro’ee Gilron, Maria S. Yaroshinsky, Melanie A. Morrison, Julia Choi, Coralie de Hemptinne, Simon Little, Philip A. Starr, Doris D. Wang
eneuro.2022; 9(6): ENEURO.0325-22.2022. CrossRef - Test-retest reliability and minimal detectable change of the computerized dynamic posturography PROPRIO for adults with chronic traumatic brain injury
Guilherme M. Cesar, Thad W. Buster, Judith M. Burnfield
Disability and Rehabilitation.2021; 43(14): 2038. CrossRef - Joint-Position Sense Accuracy Is Equally Affected by Vision among Children with and without Cerebral Palsy
Flávia de Andrade e Souza Mazuchi, Luis Mochizuki, Joseph Hamill, Patricia Martins Franciulli, Aline Bigongiari, Isabella Tábata de Almeida Martins, Ulysses Fernandes Ervilha
Journal of Motor Behavior.2021; 53(2): 209. CrossRef - Cortical responses to whole‐body balance perturbations index perturbation magnitude and predict reactive stepping behavior
Teodoro Solis‐Escalante, Mitchel Stokkermans, Michael X. Cohen, Vivian Weerdesteyn
European Journal of Neuroscience.2021; 54(12): 8120. CrossRef - White Matter Microstructure of the Cerebellar Peduncles Is Associated with Balance Performance during Sensory Re-Weighting in People with Multiple Sclerosis
Arianna D. Odom, Sutton B. Richmond, Brett W. Fling
The Cerebellum.2021; 20(1): 92. CrossRef - Highly challenging balance and gait training for individuals with Parkinson’s disease improves pace, rhythm and variability domains of gait – A secondary analysis from a randomized controlled trial
Linda Rennie, Arve Opheim, Espen Dietrichs, Niklas Löfgren, Erika Franzén
Clinical Rehabilitation.2021; 35(2): 200. CrossRef - Traumatic brain injury-induced cerebral microbleeds in the elderly
Luca Toth, Andras Czigler, Peter Horvath, Balint Kornyei, Nikolett Szarka, Attila Schwarcz, Zoltan Ungvari, Andras Buki, Peter Toth
GeroScience.2021; 43(1): 125. CrossRef - Altered prefrontal cortex responses in older adults with subjective memory complaints and dementia during dual‐task gait: An fNIRS study
Wei‐Peng Teo, Timo Rantalainen, Nathan Nuzum, Leah Valente, Helen Macpherson
European Journal of Neuroscience.2021; 53(4): 1324. CrossRef - Connectivity of the Cingulate Sulcus Visual Area (CSv) in Macaque Monkeys
V De Castro, A T Smith, A L Beer, C Leguen, N Vayssière, Y Héjja-Brichard, P Audurier, B R Cottereau, J B Durand
Cerebral Cortex.2021; 31(2): 1347. CrossRef - Efficient Actor-Critic Reinforcement Learning With Embodiment of Muscle Tone for Posture Stabilization of the Human Arm
Masami Iwamoto, Daichi Kato
Neural Computation.2021; 33(1): 129. CrossRef - Single-Session Cerebellar Transcranial Direct Current Stimulation Affects Postural Control Learning and Cerebellar Brain Inhibition in Healthy Individuals
Natsuki Katagiri, Saki Kawakami, Sayuri Okuyama, Tadaki Koseki, Daisuke Kudo, Shigehiro Namba, Shigeo Tanabe, Tomofumi Yamaguchi
The Cerebellum.2021; 20(2): 203. CrossRef - Is freezing of gait correlated with postural control in patients with moderate‐to‐severe Parkinson’s disease?
Daniel Boari Coelho, Caroline Ribeiro de Souza, Andrea Cristina de Lima‐Pardini, Renata de Castro Treza, Thiago Kenzo Fujioka Shida, Carla Silva‐Batista, Luis Augusto Teixeira, Yoland Smith
European Journal of Neuroscience.2021; 53(4): 1189. CrossRef - The use of Motor and Cognitive Dual-Task quantitative assessment on subjects with mild cognitive impairment: A systematic review
Gianmaria Mancioppi, Laura Fiorini, Erika Rovini, Filippo Cavallo
Mechanisms of Ageing and Development.2021; 193: 111393. CrossRef - Functional Near-infrared Spectroscopy Reveals the Compensatory Potential of Pre-frontal Cortical Activity for Standing Balance in Young and Older Adults
Rebecca J. St George, Mark R. Hinder, Rohan Puri, Eliza Walker, Michele L. Callisaya
Neuroscience.2021; 452: 208. CrossRef - Effects of Cognitive Over Postural Demands on Upright Standing Among Young Adults
Kell Grandjean da Costa, Erika K. Hussey, Eduardo Bodnariuc Fontes, Alekya Menta, John W. Ramsay, Clifford L. Hancock, Kari L. Loverro, Elizabeth Marfeo, Nathan Ward
Perceptual and Motor Skills.2021; 128(1): 80. CrossRef - Asymmetry and Variability Should Be Included in the Assessment of Gait Function in Poststroke Hemiplegia With Independent Ambulation During Early Rehabilitation
Woo-Sub Kim, Hanboram Choi, Jung-Woo Jung, Joon Sik Yoon, Ju Hyong Jeoung
Archives of Physical Medicine and Rehabilitation.2021; 102(4): 611. CrossRef - Electroencephalographic Study on Sensory Integration in Visually Induced Postural Sway
Takahiro Kagawa, Scott Makeig, Makoto Miyakoshi
Journal of Cognitive Neuroscience.2021; 33(3): 482. CrossRef - Benefits of nonlinear analysis indices of walking stride interval in the evaluation of neurodegenerative diseases
Frédéric Dierick, Charlotte Vandevoorde, Frédéric Chantraine, Olivier White, Fabien Buisseret
Human Movement Science.2021; 75: 102741. CrossRef - Freezing of Gait in Parkinson’s Disease: Invasive and Noninvasive Neuromodulation
Shervin Rahimpour, Wendy Gaztanaga, Amol P. Yadav, Stephano J. Chang, Max O. Krucoff, Iahn Cajigas, Dennis A. Turner, Doris D. Wang
Neuromodulation: Technology at the Neural Interface.2021; 24(5): 829. CrossRef - Response Inhibition Deficits in Women with the FMR1 Premutation are Associated with Age and Fall Risk
Carly Moser, Lyndsay Schmitt, Joseph Schmidt, Amanda Fairchild, Jessica Klusek
Brain and Cognition.2021; 148: 105675. CrossRef - The potential of noisy galvanic vestibular stimulation for optimizing and assisting human performance
Kim Lajoie, Daniel S. Marigold, Bulmaro A. Valdés, Carlo Menon
Neuropsychologia.2021; 152: 107751. CrossRef - Evaluation of vestibular functions and balance in Edirne Band musicians
Halit Selçuk, Sevgi Özdinç, Menekşe Karahan, Ayşe Zeynep Yılmazer Kayatekin, Enis Uluçam
Work.2021; 68(2): 415. CrossRef - A review of movement disorders in chemotherapy-induced neurotoxicity
Allison B. Wang, Stephen N. Housley, Ann Marie Flores, Sheetal M. Kircher, Eric J. Perreault, Timothy C. Cope
Journal of NeuroEngineering and Rehabilitation.2021;[Epub] CrossRef - REM Sleep Without Atonia and Gait Impairment in People with Mild-to-Moderate Parkinson’s Disease
Sommer L. Amundsen-Huffmaster, Matthew N. Petrucci, Maria E. Linn-Evans, Jae Woo Chung, Michael J. Howell, Aleksandar Videnovic, Paul J. Tuite, Scott E. Cooper, Colum D. MacKinnon
Journal of Parkinson's Disease.2021; 11(2): 767. CrossRef - Age-Related Changes in Presynaptic Inhibition During Gait Initiation
Solival Santos Filho, Daniel Boari Coelho, Carlos Ugrinowitsch, Caroline Ribeiro de Souza, Fernando Henrique Magalhães, Andrea Cristina de Lima-Pardini, Éden Marcos Braga de Oliveira, Eugenia Mattos, Luis Augusto Teixeira, Carla Silva-Batista, David Le Co
The Journals of Gerontology: Series A.2021; 76(4): 568. CrossRef - A synthetic kinematic index of trunk displacement conveying the overall motor condition in Parkinson’s disease
Emahnuel Troisi Lopez, Roberta Minino, Pierpaolo Sorrentino, Rosaria Rucco, Anna Carotenuto, Valeria Agosti, Domenico Tafuri, Valentino Manzo, Marianna Liparoti, Giuseppe Sorrentino
Scientific Reports.2021;[Epub] CrossRef - Gait in Benign Paroxysmal Positional Vertigo
Yong-Hyun Lim, Kyunghun Kang, Ho-Won Lee, Ji-Soo Kim, Sung-Hee Kim
Frontiers in Neurology.2021;[Epub] CrossRef - Pigeon as a model to study peripheral projections from the horizontal semicircular canal vestibular apparatus to a brainstem target immunoreactive for AMPA
João Roberto Rocha, Maria de Fátima Passetto, Julianne dos Santos Maldonado-Menetti, Ana Lúcia Beirão Cabral, Claudio Antônio Barbosa de Toledo, Marcia Koike
Acta Cirúrgica Brasileira.2021;[Epub] CrossRef - Center of pressure responses to unpredictable external perturbations indicate low accuracy in predicting fall risk in people with Parkinson’s disease
Gabriel Antonio Gazziero Moraca, Victor Spiandor Beretta, Paulo Cezar Rocha dos Santos, Priscila Nóbrega‐Sousa, Diego Orcioli‐Silva, Rodrigo Vitório, Lilian Teresa Bucken Gobbi
European Journal of Neuroscience.2021; 53(8): 2901. CrossRef - Gait analysis in a rat model of traumatic brain injury
John Reed, Antigone Grillakis, Alyssa Kline, Anwar E. Ahmed, Kimberly R. Byrnes
Behavioural Brain Research.2021; 405: 113210. CrossRef - Vitamin D, Falls and Balance Capacity Impacts in Older Adults: Update
Ray Marks
Journal of Aging Research and Healthcare.2021; 3(4): 22. CrossRef - Coordinated features in jaw and neck muscle activities induced by chewing of soft and hard gum in healthy subjects
Tomohiro Ishii, Noriyuki Narita, Hiroshi Endo, Masanobu Wakami, Masakazu Okubo, Takeshi Uchida, Ikuo Kantake, Koh Shibutani
Clinical and Experimental Dental Research.2021; 7(5): 868. CrossRef - Cortical activity and gait parameter characteristics in people with multiple sclerosis during unobstructed gait and obstacle avoidance
Felipe Balistieri Santinelli, Emerson Sebastião, Marina Hiromi Kuroda, Vinicius Christianini Moreno, Julia Pilon, Luiz Henrique Palucci Vieira, Fabio Augusto Barbieri
Gait & Posture.2021; 86: 226. CrossRef - Distinct cortical thickness patterns link disparate cerebral cortex regions to select mobility domains
Inbal Maidan, Anat Mirelman, Jeffrey M. Hausdorff, Yaakov Stern, Christian G. Habeck
Scientific Reports.2021;[Epub] CrossRef - Brain connectivity during simulated balance in older adults with and without Parkinson's disease
Elizabeth P. Pasman, Martin J. McKeown, Saurabh Garg, Taylor W. Cleworth, Bastiaan R. Bloem, J. Timothy Inglis, Mark G. Carpenter
NeuroImage: Clinical.2021; 30: 102676. CrossRef - Innovative motor and cognitive dual-task approaches combining upper and lower limbs may improve dementia early detection
Gianmaria Mancioppi, Laura Fiorini, Erika Rovini, Radia Zeghari, Auriane Gros, Valeria Manera, Philippe Robert, Filippo Cavallo
Scientific Reports.2021;[Epub] CrossRef - Cognition mediates the relation between structural network efficiency and gait in small vessel disease
Mengfei Cai, Mina A. Jacob, David G. Norris, Marco Duering, Frank-Erik de Leeuw, Anil M. Tuladhar
NeuroImage: Clinical.2021; 30: 102667. CrossRef - Does the impaired postural control in Parkinson's disease affect the habituation to non-sequential external perturbation trials?
Victor Spiandor Beretta, Mark Gregory Carpenter, Fabio Augusto Barbieri, Paulo Cezar Rocha Santos, Diego Orcioli-Silva, Marcelo Pinto Pereira, Lilian Teresa Bucken Gobbi
Clinical Biomechanics.2021; 85: 105363. CrossRef - A Neural Model of Intrinsic and Extrinsic Hippocampal Theta Rhythms: Anatomy, Neurophysiology, and Function
Stephen Grossberg
Frontiers in Systems Neuroscience.2021;[Epub] CrossRef - A randomized sham-controlled trial on the effect of continuous positive airway pressure treatment on gait control in severe obstructive sleep apnea patients
Sébastien Baillieul, Bernard Wuyam, Dominic Pérennou, Renaud Tamisier, Sébastien Bailly, Meriem Benmerad, Céline Piscicelli, Thibault Le Roux-Mallouf, Samuel Vergès, Jean-Louis Pépin
Scientific Reports.2021;[Epub] CrossRef - Detecting Depression Through Gait Data: Examining the Contribution of Gait Features in Recognizing Depression
Yameng Wang, Jingying Wang, Xiaoqian Liu, Tingshao Zhu
Frontiers in Psychiatry.2021;[Epub] CrossRef - Effects of prolonged-release fampridine on multiple sclerosis-related gait impairments. A crossover, double-blinded, placebo-controlled study
Maxime Valet, Souraya El Sankari, Vincent Van Pesch, Christine Detrembleur, Thierry Lejeune, Gaëtan Stoquart
Clinical Biomechanics.2021; 86: 105382. CrossRef - Gait Impairment and Upper Extremity Disturbance Are Associated With Total Magnetic Resonance Imaging Cerebral Small Vessel Disease Burden
Yutong Hou, Yue Li, Shuna Yang, Wei Qin, Lei Yang, Wenli Hu
Frontiers in Aging Neuroscience.2021;[Epub] CrossRef - Long-Lasting Event-Related Beta Synchronizations of Electroencephalographic Activity in Response to Support-Surface Perturbations During Upright Stance: A Pilot Study Associating Beta Rebound and Active Monitoring in the Intermittent Postural Control
Akihiro Nakamura, Yasuyuki Suzuki, Matija Milosevic, Taishin Nomura
Frontiers in Systems Neuroscience.2021;[Epub] CrossRef - Dual-task walking and automaticity after Stroke: Insights from a secondary analysis and imaging sub-study of a randomised controlled trial
Johnny Collett, Melanie K Fleming, Daan Meester, Emad Al-Yahya, Derick T Wade, Andrea Dennis, Piergiorgio Salvan, Andrew Meaney, Janet Cockburn, Joanna Dawes, Heidi Johansen-Berg, Helen Dawes
Clinical Rehabilitation.2021; 35(11): 1599. CrossRef - Aerobic Exercise Combined With Transcranial Direct Current Stimulation Over the Prefrontal Cortex in Parkinson Disease: Effects on Cortical Activity, Gait, and Cognition
Núbia Ribeiro Conceição, Lilian Teresa Bucken Gobbi, Priscila Nóbrega-Sousa, Diego Orcioli-Silva, Victor Spiandor Beretta, Ellen Lirani-Silva, Alexandre Hideki Okano, Rodrigo Vitório
Neurorehabilitation and Neural Repair.2021; 35(8): 717. CrossRef - Non-ambulatory measures of lower extremity sensorimotor function are associated with walking function in Multiple Sclerosis
Sumire Sato, John Buonaccorsi, Jules D. Miehm, Jongil Lim, Caitlin Rajala, Farnaz Khalighinejad, Carolina Ionete, Jane A. Kent, Richard E.A. van Emmerik
Multiple Sclerosis and Related Disorders.2021; 53: 103051. CrossRef - Self-Perception of the Knee Is Associated with Joint Motion during the Loading Response in Individuals with Knee Osteoarthritis: A Pilot Cross-Sectional Study
Haruki Toda, Tsubasa Maruyama, Koji Fujita, Yuki Yamauchi, Mitsunori Tada
Sensors.2021; 21(12): 4009. CrossRef - Fields of Forel Brain Stimulation Improves Levodopa-Unresponsive Gait and Balance Disorders in Parkinson's Disease
Maria Sheila Guimarães Rocha, Julian Leticia de Freitas, Carlos Daniel Miranda Costa, Maira Okada de Oliveira, Paulo Roberto Terzian, João Welberthon Matos Queiroz, Jamana Barbosa Ferraz, João Fellipe Santos Tatsch, Diogo Coutinho Soriano, Clement Hamani,
Neurosurgery.2021; 89(3): 450. CrossRef - The effects of transcranial direct current stimulation on gait in patients with Parkinson’s disease: a systematic review
Fateme Pol, Mohammad Ali Salehinejad, Hamzeh Baharlouei, Michael A. Nitsche
Translational Neurodegeneration.2021;[Epub] CrossRef - Cerebral Hemodynamic Responses to the Difficulty Level of Ambulatory Tasks in Patients With Parkinson’s Disease: A Systematic Review and Meta-Analysis
Jin P. Lin, Hong S. Feng, Hua Zhai, Xia Shen
Neurorehabilitation and Neural Repair.2021; 35(9): 755. CrossRef - The Dendrite Arbor of Purkinje Cells Is Altered Following to Tail Regeneration in the Leopard Gecko
Stefanie S Bradley, Erika Howe, Craig D C Bailey, Matthew K Vickaryous
Integrative and Comparative Biology.2021; 61(2): 370. CrossRef - The diagnosis of central vestibular disorder based on the complementary examination of the vestibulospinal reflex
Stefani Maihoub, András Molnár, László Tamás, Ágnes Szirmai
Journal of Otology.2021;[Epub] CrossRef - Compromised Brain Activity With Age During a Game-Like Dynamic Balance Task: Single- vs. Dual-Task Performance
Veerle de Rond, Diego Orcioli-Silva, Bauke Wybren Dijkstra, Jean-Jacques Orban de Xivry, Annette Pantall, Alice Nieuwboer
Frontiers in Aging Neuroscience.2021;[Epub] CrossRef - Cognitive and Motor Cortical Activity During Cognitively Demanding Stepping Tasks in Older People at Low and High Risk of Falling
Paulo H. S. Pelicioni, Stephen R. Lord, Daina L. Sturnieks, Bethany Halmy, Jasmine C. Menant
Frontiers in Medicine.2021;[Epub] CrossRef - Uniqueness of gait kinematics in a cohort study
Gunwoo Park, Kyoung Min Lee, Seungbum Koo
Scientific Reports.2021;[Epub] CrossRef - Visual Effect on Brain Connectome That Scales Feedforward and Feedback Processes of Aged Postural System During Unstable Stance
Yi-Ching Chen, Chien-Chun Huang, Chen-Guang Zhao, Ing-Shiou Hwang
Frontiers in Aging Neuroscience.2021;[Epub] CrossRef - The Biology and Pathobiology of Glutamatergic, Cholinergic, and Dopaminergic Signaling in the Aging Brain
Anna Gasiorowska, Malgorzata Wydrych, Patrycja Drapich, Maciej Zadrozny, Marta Steczkowska, Wiktor Niewiadomski, Grazyna Niewiadomska
Frontiers in Aging Neuroscience.2021;[Epub] CrossRef - Dual-Task Training Effect on Cognitive and Body Function, β-amyloid Levels in Alzheimer’s Dementia Patients: A Randomized Controlled Trial
Seung-Min Nam, Seong-gil Kim
The Journal of Korean Physical Therapy.2021; 33(3): 136. CrossRef - Graph‐theoretical analysis of EEG functional connectivity during balance perturbation in traumatic brain injury: A pilot study
Vikram Shenoy Handiru, Alaleh Alivar, Armand Hoxha, Soha Saleh, Easter S. Suviseshamuthu, Guang H. Yue, Didier Allexandre
Human Brain Mapping.2021; 42(14): 4427. CrossRef - Adapting Footfall Rhythmicity to Auditory Perturbations Affects Resilience of Locomotor Behavior: A Proof-of-Concept Study
Deepak K. Ravi, Caroline C. Heimhofer, William R. Taylor, Navrag B. Singh
Frontiers in Neuroscience.2021;[Epub] CrossRef - Towards real-world generalizability of a circuit for action-stopping
Ricci Hannah, Adam R. Aron
Nature Reviews Neuroscience.2021; 22(9): 538. CrossRef - Physiological and cognitive determinants of gait in middle-aged, older-aged and oldest-aged Asian adults – The Yishun study
Lay Khoon Lau, Shiou Liang Wee, Jagadish Ullal Mallya, Philip Lin Kiat Yap, Wei Jun Benedict Pang, Kexun Kenneth Chen, Khalid Abdul Jabbar, Wei Ting Seah, Tze Pin Ng
Aging and Health Research.2021; 1(3): 100030. CrossRef - Amble Gait EEG Points at Complementary Cortical Networks Underlying Stereotypic Multi-Limb Co-ordination
Joyce B. Weersink, Natasha M. Maurits, Bauke M. de Jong
Frontiers in Human Neuroscience.2021;[Epub] CrossRef - Age-Related Differences in Corticospinal Excitability and Anticipatory Postural Adjustments of the Trunk
Rebecca S. Rowland, Ned Jenkinson, Shin-Yi Chiou
Frontiers in Aging Neuroscience.2021;[Epub] CrossRef - Postural sway in the moving room scenario: New evidence for functional dissociation between self-motion perception and postural control
Kentaro Horiuchi, Kuniyasu Imanaka, Masami Ishihara, Manabu Sakakibara
PLOS ONE.2021; 16(9): e0257212. CrossRef - Altered Cortical Cholinergic Network in Parkinson’s Disease at Different Stage: A Resting-State fMRI Study
Wenshuang Sheng, Tao Guo, Cheng Zhou, Jingjing Wu, Ting Gao, Jiali Pu, Baorong Zhang, Minming Zhang, Yunjun Yang, Xiaojun Guan, Xiaojun Xu
Frontiers in Aging Neuroscience.2021;[Epub] CrossRef - Gait phenotype in batten disease: A marker of disease progression
John R. Ostergaard
European Journal of Paediatric Neurology.2021;[Epub] CrossRef - High Sensory Responsiveness in Older Adults is Associated with Walking Outside but Not Inside: Proof of Concept Study
Maayan Agmon, Tami Bar-Shalita, Rachel Kizony
Clinical Interventions in Aging.2021; Volume 16: 1651. CrossRef - Association of Posture Instability with Dopamine Drop of Nigrostriatal System and Hypometabolism of Cerebral Cortex in Parkinson’s Disease
Hongyan Wang, Hong-Yu Li, Xiuhai Guo, Yongtao Zhou
Current Neurovascular Research.2021; 18(2): 244. CrossRef - Does Subthalamic Deep Brain Stimulation Impact Asymmetry and Dyscoordination of Gait in Parkinson’s Disease?
Deepak K. Ravi, Christian R. Baumann, Elena Bernasconi, Michelle Gwerder, Niklas K. Ignasiak, Mechtild Uhl, Lennart Stieglitz, William R. Taylor, Navrag B. Singh
Neurorehabilitation and Neural Repair.2021; 35(11): 1020. CrossRef - Any Behavioral Change May Have Physiological Significance: Benign Neglect In Tier I Neurotoxicity Testing
David V. Gauvin, Zachary J. Zimmermann
Current Opinion in Toxicology.2021;[Epub] CrossRef - Impact of regional white matter hyperintensities on specific gait function in Alzheimer's disease and mild cognitive impairment
Noriko Ogama, Hidetoshi Endo, Shosuke Satake, Shumpei Niida, Hidenori Arai, Takashi Sakurai
Journal of Cachexia, Sarcopenia and Muscle.2021; 12(6): 2045. CrossRef - The effects of different frequencies of rhythmic acoustic stimulation on gait stability in healthy elderly individuals: a pilot study
Roberta Minino, Emahnuel Troisi Lopez, Pierpaolo Sorrentino, Rosaria Rucco, Anna Lardone, Matteo Pesoli, Domenico Tafuri, Laura Mandolesi, Giuseppe Sorrentino, Marianna Liparoti
Scientific Reports.2021;[Epub] CrossRef - Feasibility and tolerance of a robotic postural training to improve standing in a person with ambulatory spinal cord injury
V. Santamaria, T. D. Luna, S. K. Agrawal
Spinal Cord Series and Cases.2021;[Epub] CrossRef - A Novel Viewpoint on the Anticipatory Postural Adjustments During Gait Initiation
Veronica Farinelli, Francesco Bolzoni, Silvia Maria Marchese, Roberto Esposti, Paolo Cavallari
Frontiers in Human Neuroscience.2021;[Epub] CrossRef - Tai Chi and Yoga for Improving Balance on One Leg: A Neuroimaging and Biomechanics Study
Xin-Peng Chen, Le-Jun Wang, Xiao-Qian Chang, Kuan Wang, Hui-Fang Wang, Ming Ni, Wen-Xin Niu, Ming Zhang
Frontiers in Neurology.2021;[Epub] CrossRef - Sleep deprivation affects gait control
Guilherme S. Umemura, João Pedro Pinho, Jacques Duysens, Hermano Igo Krebs, Arturo Forner-Cordero
Scientific Reports.2021;[Epub] CrossRef - Postural Control Strategies and Balance-Related Factors in Individuals with Traumatic Transtibial Amputations
Barbora Kolářová, Miroslav Janura, Zdeněk Svoboda, Petr Kolář, Dagmar Tečová, Milan Elfmark
Sensors.2021; 21(21): 7284. CrossRef - Walking While Talking and Prefrontal Oxygenation in Motoric Cognitive Risk Syndrome: Clinical and Pathophysiological Aspects
Cristina Udina, Emmeline Ayers, Marco Inzitari, Joe Verghese, Marco Canevelli
Journal of Alzheimer's Disease.2021; 84(4): 1585. CrossRef - Cortical and Cerebellar Oscillatory Responses to Postural Instability in Parkinson's Disease
Taylor J. Bosch, Stefan Kammermeier, Christopher Groth, Matt Leedom, Elizabeth K. Hanson, Patti Berg-Poppe, Arun Singh
Frontiers in Neurology.2021;[Epub] CrossRef - Circuits for State-Dependent Modulation of Locomotion
Alejandro J. Pernía-Andrade, Nikolaus Wenger, Maria S. Esposito, Philip Tovote
Frontiers in Human Neuroscience.2021;[Epub] CrossRef - Postural and gait symptoms in de novo Parkinson's disease patients correlate with cholinergic white matter pathology
Muhammad Nazmuddin, Jan-Willem van Dalen, Ronald J.H. Borra, Gilles N. Stormezand, Harm Jan van der Horn, Sygrid van der Zee, Jeffrey Boertien, Teus van Laar
Parkinsonism & Related Disorders.2021; 93: 43. CrossRef - Neurophysiological Support of Motor Control in “Hybrid” Postures. Literature Review
N. D. Babanov, E. A. Biryukova
Neuroscience and Behavioral Physiology.2021; 51(8): 1162. CrossRef - A Narrative Review of Alternate Gait Training Using Knee-ankle-foot Orthosis in Stroke Patients with Severe Hemiparesis
Hiroaki ABE, Kei KADOWAKI, Naohide TSUJIMOTO, Toru OKANUKA
Physical Therapy Research.2021; 24(3): 195. CrossRef - Intrinsic brainstem circuits comprised of Chx10-expressing neurons contribute to reticulospinal output in mice
Jeremy W. Chopek, Ying Zhang, Robert M. Brownstone
Journal of Neurophysiology.2021; 126(6): 1978. CrossRef - Spinal Cord Circuits: Models and Reality
Uwe Windhorst
Neurophysiology.2021; 53(3-6): 142. CrossRef - Cerebellar transcranial direct current stimulation modulates the effect of cerebellar transcranial magnetic stimulation on the excitability of spinal reflex
Akiyoshi Matsugi, Yohei Okada
Neuroscience Research.2020; 150: 37. CrossRef - Dynamic running hexapod robot based on high-performance computing
Xiaokun Leng, Songhao Piao, Lin Chang, Zhicheng He, Zheng Zhu
The Journal of Supercomputing.2020; 76(2): 844. CrossRef - Optic flow and attention alter locomotion differently in the young and old
Kenneth S. Pechtl, J. Richard Jennings, Mark S. Redfern
Gait & Posture.2020; 76: 1. CrossRef - Axonal regeneration and functional recovery driven by endogenous Nogo receptor antagonist LOTUS in a rat model of unilateral pyramidotomy
Ryu Ueno, Hajime Takase, Jun Suenaga, Masao Kishimoto, Yuji Kurihara, Kohtaro Takei, Nobutaka Kawahara, Tetsuya Yamamoto
Experimental Neurology.2020; 323: 113068. CrossRef - Local dynamic stability during long-fatiguing walks in people with multiple sclerosis
I. Arpan, P.C. Fino, B.W. Fling, F. Horak
Gait & Posture.2020; 76: 122. CrossRef - Instrumental assessment of balance and gait in depression: A systematic review
Martino Belvederi Murri, Federico Triolo, Alice Coni, Carlo Tacconi, Erika Nerozzi, Andrea Escelsior, Matteo Respino, Francesca Neviani, Marco Bertolotti, Klea Bertakis, Lorenzo Chiari, Stamatula Zanetidou, Mario Amore
Psychiatry Research.2020; 284: 112687. CrossRef - Baropodometric evaluation of foot load distribution during gait in the group of professionally active nurses
Anna Kołcz, Natalia Główka, Mateusz Kowal, Małgorzata Paprocka‐Borowicz
Journal of Occupational Health.2020;[Epub] CrossRef - Effect of aging on H-reflex response to fatigue
Andrew Philip Lavender, Sadik Balkozak, Mustafa Görkem Özyurt, Betilay Topkara, İlhan Karacan, İdil Bilici, Anne-Marie Hill, Kemal Sitki Türker
Experimental Brain Research.2020; 238(2): 273. CrossRef - The repeatability of the instrumented timed Up & Go test: The performance of older adults and parkinson’s disease patients under different conditions
Slavka Viteckova, Radim Krupicka, Petr Dusek, Vaclav Cejka, Patrik Kutilek, Jan Novak, Zoltan Szabo, Evžen Růžička
Biocybernetics and Biomedical Engineering.2020; 40(1): 363. CrossRef - Cerebral Cortical Activity Following Non-invasive Cerebellar Stimulation—a Systematic Review of Combined TMS and EEG Studies
Lara Fernandez, Nigel C. Rogasch, Michael Do, Gillian Clark, Brendan P. Major, Wei-Peng Teo, Linda K. Byrne, Peter G. Enticott
The Cerebellum.2020; 19(2): 309. CrossRef - Resting-state fMRI reveals increased functional connectivity in the cerebellum but decreased functional connectivity of the caudate nucleus in Parkinson’s disease
Oliver Kaut, Clemens Mielacher, René Hurlemann, Ullrich Wüllner
Neurological Research.2020; 42(1): 62. CrossRef - Gait Generation and Its Energy Efficiency Based on Rat Neuromusculoskeletal Model
Misaki Toeda, Shinya Aoi, Soichiro Fujiki, Tetsuro Funato, Kazuo Tsuchiya, Dai Yanagihara
Frontiers in Neuroscience.2020;[Epub] CrossRef - Cognitive and physical markers of prodromal dementia: A 12‐year‐long population study
Giulia Grande, Debora Rizzuto, Davide L. Vetrano, Anna Marseglia, Nicola Vanacore, Erika J. Laukka, Anna‐Karin Welmer, Laura Fratiglioni
Alzheimer's & Dementia.2020; 16(1): 153. CrossRef - The sensory role of the sole of the foot: Review and update on clinical perspectives
Frederic J.F. Viseux
Neurophysiologie Clinique.2020; 50(1): 55. CrossRef - Overactivity in Chronic Pain, the Role of Pain-related Endurance and Neuromuscular Activity
Monika I. Hasenbring, Nicole E. Andrews, Gerold Ebenbichler
The Clinical Journal of Pain.2020; 36(3): 162. CrossRef - Motor tract integrity predicts walking recovery
Julie Soulard, Coline Huber, Sebastien Baillieul, Antoine Thuriot, Felix Renard, Bérengère Aubert Broche, Alexandre Krainik, Nicolas Vuillerme, Assia Jaillard
Neurology.2020; 94(6): e583. CrossRef - Altered intra- and inter-network functional connectivity in patients with persistent postural-perceptual dizziness
Kangzhi Li, Lihong Si, Bin Cui, Xia Ling, Bo Shen, Xu Yang
NeuroImage: Clinical.2020; 26: 102216. CrossRef - The role of physical exercise and rehabilitation in delirium
N. Gual, M. García-Salmones, L. Brítez, N. Crespo, C. Udina, L. M. Pérez, M. Inzitari
European Geriatric Medicine.2020; 11(1): 83. CrossRef - Neural circuits of idiopathic Normal Pressure Hydrocephalus: A perspective review of brain connectivity and symptoms meta-analysis
Alessandra Griffa, Dimitri Van De Ville, François R. Herrmann, Gilles Allali
Neuroscience & Biobehavioral Reviews.2020; 112: 452. CrossRef - Orbitrap mass spectrometry for monitoring the ganglioside pattern in human cerebellum development and aging
Raluca Ica, Alina Petrut, Cristian V.A. Munteanu, Mirela Sarbu, Željka Vukelić, Ligia Petrica, Alina D. Zamfir
Journal of Mass Spectrometry.2020;[Epub] CrossRef - What are the association patterns between handgrip strength and adverse health conditions? A topical review
Ryan McGrath, Nathaniel Johnson, Lukus Klawitter, Sean Mahoney, Kara Trautman, Caroline Carlson, Ella Rockstad, Kyle J Hackney
SAGE Open Medicine.2020; 8: 205031212091035. CrossRef - Cortical Oscillations during Gait: Wouldn’t Walking Be So Automatic?
Arnaud Delval, Madli Bayot, Luc Defebvre, Kathy Dujardin
Brain Sciences.2020; 10(2): 90. CrossRef - Loss of presynaptic inhibition for step initiation in parkinsonian individuals with freezing of gait
Jumes Leopoldino Oliveira Lira, Carlos Ugrinowitsch, Daniel Boari Coelho, Luis Augusto Teixeira, Andrea Cristina de Lima‐Pardini, Fernando Henrique Magalhães, Egberto Reis Barbosa, Fay B. Horak, Carla Silva‐Batista
The Journal of Physiology.2020; 598(8): 1611. CrossRef - Which Effects on Neuroanatomy and Path-Integration Survive? Results of a Randomized Controlled Study on Intensive Balance Training
Milos Dordevic, Marco Taubert, Patrick Müller, Martin Riemer, Jörn Kaufmann, Anita Hökelmann, Notger G. Müller
Brain Sciences.2020; 10(4): 210. CrossRef - Freezing of gait in Parkinson’s disease: pathophysiology, risk factors and treatments
Chao Gao, Jun Liu, Yuyan Tan, Shengdi Chen
Translational Neurodegeneration.2020;[Epub] CrossRef - Clinical experience of comprehensive treatment on the balance function of Parkinsonʼs disease
Haitao Li, Siquan Liang, Yang Yu, Yue Wang, Yuanyuan Cheng, Hechao Yang, Xiaoguang Tong
Medicine.2020; 99(19): e20154. CrossRef - Digital natives and dual task: Handling it but not immune against cognitive-locomotor interferences
Frédéric Dierick, Fabien Buisseret, Mathieu Renson, Adèle Mae Luta, Slavko Rogan
PLOS ONE.2020; 15(5): e0232328. CrossRef - Functional neuroimaging of human postural control: A systematic review with meta-analysis
Bauke W. Dijkstra, Esther M.J. Bekkers, Moran Gilat, Veerle de Rond, Robert M. Hardwick, Alice Nieuwboer
Neuroscience & Biobehavioral Reviews.2020; 115: 351. CrossRef - The neural correlates of falls: Alterations in large-scale resting-state networks in elderly fallers
Inbal Maidan, Amgad Droby, Yael Jacob, Nir Giladi, Jeffrey M Hausdorff, Anat Mirelman
Gait & Posture.2020; 80: 56. CrossRef - Short rehabilitation training program may improve postural control in children with autism spectrum disorders: preliminary evidences
Simona Caldani, Paola Atzori, Hugo Peyre, Richard Delorme, Maria Pia Bucci
Scientific Reports.2020;[Epub] CrossRef - Effects of injuries to descending motor pathways on restoration of gait in patients with pontine hemorrhage
Sang Seok Yeo, Sung Ho Jang, Ga Young Park, Seunghue Oh
Journal of Stroke and Cerebrovascular Diseases.2020; 29(7): 104857. CrossRef - Handgrip strength accuracy as discriminator of functional independence in centenarian women
Artur Rodrigues Fortunato, Raquel Ester Lima da Silva, Giovana Zarpellon Mazo
Revista Brasileira de Cineantropometria & Desempenho Humano.2020;[Epub] CrossRef - Assessing the effect of current steering on the total electrical energy delivered and ambulation in Parkinson’s disease
Daphne Hui, Aditya A. Murgai, Greydon Gilmore, Shabna I. Mohideen, Andrew G. Parrent, Mandar S. Jog
Scientific Reports.2020;[Epub] CrossRef - Speech disorders and anxiety: interaction mechanisms and therapy potential
E.E. Vasenina, O.S. Levin
Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova.2020; 120(4): 136. CrossRef - Progression of motor disability in cerebral palsy: The role of concomitant epilepsy
Tomoyuki Takano, Anri Hayashi, Yuki Harada
Seizure.2020; 80: 81. CrossRef - Turning Characteristics of the More-Affected Side in Parkinson’s Disease Patients with Freezing of Gait
Hwayoung Park, Changhong Youm, Myeounggon Lee, Byungjoo Noh, Sang-Myung Cheon
Sensors.2020; 20(11): 3098. CrossRef - Fifteen Years of Wireless Sensors for Balance Assessment in Neurological Disorders
Alessandro Zampogna, Ilaria Mileti, Eduardo Palermo, Claudia Celletti, Marco Paoloni, Alessandro Manoni, Ivan Mazzetta, Gloria Dalla Costa, Carlos Pérez-López, Filippo Camerota, Letizia Leocani, Joan Cabestany, Fernanda Irrera, Antonio Suppa
Sensors.2020; 20(11): 3247. CrossRef - Muscle Synergies in Parkinson’s Disease
Ilaria Mileti, Alessandro Zampogna, Alessandro Santuz, Francesco Asci, Zaccaria Del Prete, Adamantios Arampatzis, Eduardo Palermo, Antonio Suppa
Sensors.2020; 20(11): 3209. CrossRef - Transcranial direct current stimulation combined with physical or cognitive training in people with Parkinson’s disease: a systematic review
Victor Spiandor Beretta, Núbia Ribeiro Conceição, Priscila Nóbrega-Sousa, Diego Orcioli-Silva, Luana Karla Braz Fonseca Dantas, Lilian Teresa Bucken Gobbi, Rodrigo Vitório
Journal of NeuroEngineering and Rehabilitation.2020;[Epub] CrossRef - Assessing the Temporal Organization of Walking Variability: A Systematic Review and Consensus Guidelines on Detrended Fluctuation Analysis
Deepak K. Ravi, Vivien Marmelat, William R. Taylor, Karl M. Newell, Nick Stergiou, Navrag B. Singh
Frontiers in Physiology.2020;[Epub] CrossRef - Backward locomotor treadmill training combined with transcutaneous spinal direct current stimulation in stroke: a randomized pilot feasibility and safety study
Oluwole O Awosika, Saira Matthews, Emily J Staggs, Pierce Boyne, Xiao Song, Bridget A Rizik, Heidi J Sucharew, Christina Zhang, Gabrielle Mungcal, Rohitha Moudgal, Amit Bhattacharya, Kari Dunning, Daniel Woo, Brett M Kissela
Brain Communications.2020;[Epub] CrossRef - Behavioural manifestations and associated non-motor features of freezing of gait: A narrative review and theoretical framework
Kaylena A. Ehgoetz Martens, Daniel S. Peterson, Quincy J. Almeida, Simon J.G. Lewis, Jeffrey M. Hausdorff, Alice Nieuwboer
Neuroscience & Biobehavioral Reviews.2020; 116: 350. CrossRef - New insight into Parkinson’s disease‐related impairment of the automatic control of upright stance
Cédrick T. Bonnet, Arnaud Delval, Tarkeshwar Singh, Yann‐Romain Kechabia, Luc Defebvre
European Journal of Neuroscience.2020; 52(12): 4851. CrossRef - Firing activity of locus coeruleus noradrenergic neurons decreases in necdin-deficient mice, an animal model of Prader–Willi syndrome
Rui-Ni Wu, Wei-Chen Hung, Ching-Tsuey Chen, Li-Ping Tsai, Wen-Sung Lai, Ming-Yuan Min, Shi-Bing Wong
Journal of Neurodevelopmental Disorders.2020;[Epub] CrossRef - A functional observational battery for evaluation of neurological outcomes in a rat model of acute bacterial meningitis
Jane Fisher, Chiara Pavan, Luisa S. Ohlmeier, Bo Nilson, Iben Lundgaard, Adam Linder, Peter Bentzer
Intensive Care Medicine Experimental.2020;[Epub] CrossRef - Impact of Extremity Manipulation on Postural Sway Characteristics: A Preliminary, Randomized Crossover Study
Christopher A. Malaya, Joshua Haworth, Katherine A. Pohlman, Cody Powell, Dean L. Smith
Journal of Manipulative and Physiological Therapeutics.2020; 43(5): 457. CrossRef - Dissociated motor learning and de-adaptation in patients with functional gait disorders
Denise Lin, Patricia Castro, Amy Edwards, Akila Sekar, Mark J Edwards, Jan Coebergh, Adolfo M Bronstein, Diego Kaski
Brain.2020; 143(8): 2594. CrossRef - Multicenter Validation of Metabolic Abnormalities Related to PSP According to the MDS‐PSP Criteria
Gloria Martí‐Andrés, Liza van Bommel, Sanne K. Meles, Mario Riverol, Rafael Valentí, Rosalie V. Kogan, Remco J. Renken, Vita Gurvits, Teus van Laar, Marco Pagani, Elena Prieto, M. Rosario Luquin, Klaus L. Leenders, Javier Arbizu
Movement Disorders.2020; 35(11): 2009. CrossRef - Gait initiation in progressive supranuclear palsy: brain metabolic correlates
Chiara Palmisano, Massimiliano Todisco, Giorgio Marotta, Jens Volkmann, Claudio Pacchetti, Carlo A. Frigo, Gianni Pezzoli, Ioannis U. Isaias
NeuroImage: Clinical.2020; 28: 102408. CrossRef - Altered Brain Function in Cerebral Small Vessel Disease Patients With Gait Disorders: A Resting-State Functional MRI Study
Xia Zhou, Chao Zhang, Linlin Li, Yimei Zhang, Wei Zhang, Wenwen Yin, Xianfeng Yu, Xiaoqun Zhu, Yinfeng Qian, Zhongwu Sun
Frontiers in Aging Neuroscience.2020;[Epub] CrossRef - Lower Thalamic Blood Flow Is Associated With Slower Stride Velocity in Older Adults
Noah D. Koblinsky, Sarah Atwi, Ellen Cohen, Nicole D. Anderson, Carol E. Greenwood, Bradley J. MacIntosh, Andrew D. Robertson
Frontiers in Aging Neuroscience.2020;[Epub] CrossRef - Gait-related frequency modulation of beta oscillatory activity in the subthalamic nucleus of parkinsonian patients
Andrea Canessa, Chiara Palmisano, Ioannis U. Isaias, Alberto Mazzoni
Brain Stimulation.2020;[Epub] CrossRef - Immersive Virtual Reality to Restore Natural Long-Range Autocorrelations in Parkinson’s Disease Patients’ Gait During Treadmill Walking
Alexis Lheureux, Julien Lebleu, Caroline Frisque, Corentin Sion, Gaëtan Stoquart, Thibault Warlop, Christine Detrembleur, Thierry Lejeune
Frontiers in Physiology.2020;[Epub] CrossRef - Non-pharmacological Treatment Challenges in Early Parkinson's Disease for Axial and Cognitive Symptoms: A Mini Review
Gabriella Sharpe, Antonella Macerollo, Margherita Fabbri, Elina Tripoliti
Frontiers in Neurology.2020;[Epub] CrossRef - Genetic basis of falling risk susceptibility in the UK Biobank Study
Katerina Trajanoska, Lotta J. Seppala, Carolina Medina-Gomez, Yi-Hsiang Hsu, Sirui Zhou, Natasja M. van Schoor, Lisette C. P. G. M. de Groot, David Karasik, J. Brent Richards, Douglas P. Kiel, Andre G. Uitterlinden, John R. B. Perry, Nathalie van der Veld
Communications Biology.2020;[Epub] CrossRef - Effect of Different Intensities of Transcranial Direct Current Stimulation on Postural Response to External Perturbation in Patients With Parkinson’s Disease
Victor Spiandor Beretta, Rodrigo Vitório, Priscila Nóbrega-Sousa, Núbia Ribeiro Conceição, Diego Orcioli-Silva, Marcelo Pinto Pereira, Lilian Teresa Bucken Gobbi
Neurorehabilitation and Neural Repair.2020; 34(11): 1009. CrossRef - Adapting to the Mechanical Properties and Active Force of an Exoskeleton by Altering Muscle Synergies in Chronic Stroke Survivors
Linda Rinaldi, Ling-Fung Yeung, Patrick Chi-Hong Lam, Marco Y. C. Pang, Raymond Kai-Yu Tong, Vincent C. K. Cheung
IEEE Transactions on Neural Systems and Rehabilitation Engineering.2020; 28(10): 2203. CrossRef - Brain networks associated with anticipatory postural adjustments in Parkinson’s disease patients with freezing of gait
Andrea C. de Lima-Pardini, Daniel B. Coelho, Mariana P. Nucci, Catarina C. Boffino, Alana X. Batista, Raymundo M. de Azevedo Neto, Carla Silva-Batista, Egberto R. Barbosa, Rajal G. Cohen, Fay B. Horak, Luis A. Teixeira, Edson Amaro Jr
NeuroImage: Clinical.2020; 28: 102461. CrossRef - Rhythmic neural activity is comodulated with short-term gait modifications during first-time use of a dummy prosthesis: a pilot study
Vera G. M. Kooiman, Helco G. van Keeken, Natasha M. Maurits, Vivian Weerdesteyn, Teodoro Solis-Escalante
Journal of NeuroEngineering and Rehabilitation.2020;[Epub] CrossRef - Deep brain stimulation: a review of the open neural engineering challenges
Matteo Vissani, Ioannis U Isaias, Alberto Mazzoni
Journal of Neural Engineering.2020; 17(5): 051002. CrossRef - History of and Insights Into Spinal Cord Stimulation in Parkinson Disease
Bruno Braz Garcia, Edson Ricardo Junior, Mariana Ferreira Pereira de Araújo, Hougelle Simplício
Neurorehabilitation and Neural Repair.2020; 34(11): 967. CrossRef - Influence of Robotic Mechanotherapy in Various Combinations with Non-Invasive Electrostimulation of Muscles and Spinal Cord on the Postural Balance in Children with Severe Forms of Cerebral Palsy
I.E. Nikityuk, E.L. Kononova, G.A. Ikoeva, I.Yu Solokhina
Bulletin of Restorative Medicine.2020; 98(4): 26. CrossRef - Toward a Regulatory Qualification of Real-World Mobility Performance Biomarkers in Parkinson’s Patients Using Digital Mobility Outcomes
Marco Viceconti, Sabina Hernandez Penna, Wilhelmus Dartee, Claudia Mazzà, Brian Caulfield, Clemens Becker, Walter Maetzler, Judith Garcia-Aymerich, Giorgio Davico, Lynn Rochester
Sensors.2020; 20(20): 5920. CrossRef - Brain Network Oscillations During Gait in Parkinson’s Disease
Doris D. Wang, Julia T. Choi
Frontiers in Human Neuroscience.2020;[Epub] CrossRef - Disrupted white matter integrity and network connectivity are related to poor motor performance
Feifei Zhai, Jie Liu, Ning Su, Fei Han, Lixin Zhou, Jun Ni, Ming Yao, Shuyang Zhang, Zhengyu Jin, Liying Cui, Feng Tian, Yicheng Zhu
Scientific Reports.2020;[Epub] CrossRef - Serotonergic Modulation of Locomotor Activity From Basal Vertebrates to Mammals
Aurélie Flaive, Maxime Fougère, Cornelis Immanuel van der Zouwen, Dimitri Ryczko
Frontiers in Neural Circuits.2020;[Epub] CrossRef - Classification of Rhythmic Cortical Activity Elicited by Whole-Body Balance Perturbations Suggests the Cortical Representation of Direction-Specific Changes in Postural Stability
Teodoro Solis-Escalante, Digna De Kam, Vivian Weerdesteyn
IEEE Transactions on Neural Systems and Rehabilitation Engineering.2020; 28(11): 2566. CrossRef - Executive Control of Walking in People With Parkinson’s Disease With Freezing of Gait
Rodrigo Vitorio, Samuel Stuart, Martina Mancini
Neurorehabilitation and Neural Repair.2020; 34(12): 1138. CrossRef - Postural instability in Parkinson’s disease: Review and bottom-up rehabilitative approaches
Frederic J.F. Viseux, Arnaud Delval, Luc Defebvre, Martin Simoneau
Neurophysiologie Clinique.2020; 50(6): 479. CrossRef - Can dual-task paradigms predict Falls better than single task? – A systematic literature review
Madli Bayot, Kathy Dujardin, Lucile Dissaux, Céline Tard, Luc Defebvre, Cédrick T. Bonnet, Etienne Allart, Gilles Allali, Arnaud Delval
Neurophysiologie Clinique.2020; 50(6): 401. CrossRef - Neural Correlates of Freezing of Gait in Parkinson's Disease: An Electrophysiology Mini-Review
J. Sebastian Marquez, S. M. Shafiul Hasan, Masudur R. Siddiquee, Corneliu C. Luca, Virendra R. Mishra, Zoltan Mari, Ou Bai
Frontiers in Neurology.2020;[Epub] CrossRef - Association of Postural Instability with Autonomic Dysfunction in Early Parkinson’s Disease
Sooyeoun You, Hyun Ah Kim, Hyung Lee
Journal of Clinical Medicine.2020; 9(11): 3786. CrossRef - Neural Mechanisms for Locomotor and Postural Control in Man and Its Application to Neurorehabilitation
Ichiro Miyai
The Japanese Journal of Rehabilitation Medicine.2020; 57(10): 965. CrossRef - A case of generalized tonic seizures related to acute myocarditis
Jeong-Hwan Yang, Jae Yoon Na, Jinseok Lee, Da-Eun Kim, Jinyoung Song, I-Seok Kang, Hyeryun Yeh
Pediatric Emergency Medicine Journal.2020; 7(2): 127. CrossRef - Rapid and robust patterns of spontaneous locomotor deficits in mouse models of Huntington’s disease
Taneli Heikkinen, Timo Bragge, Niina Bhattarai, Teija Parkkari, Jukka Puoliväli, Outi Kontkanen, Patrick Sweeney, Larry C. Park, Ignacio Munoz-Sanjuan, Yuqing Li
PLOS ONE.2020; 15(12): e0243052. CrossRef - The Relationship of Rapid Eye Movement Sleep Behavior Disorder and Freezing of Gait in Parkinson’s Disease
Chelsea Mae N Nobleza, Mariah Siddiqui, Parth V Shah, Prachi Balani, Angel R Lopez, Safeera Khan
Cureus.2020;[Epub] CrossRef - Influence of Autocorrelated Rhythmic Auditory Stimulations on Parkinson’s Disease Gait Variability: Comparison With Other Auditory Rhythm Variabilities and Perspectives
Alexis Lheureux, Thibault Warlop, Charline Cambier, Baptiste Chemin, Gaëtan Stoquart, Christine Detrembleur, Thierry Lejeune
Frontiers in Physiology.2020;[Epub] CrossRef - A Roadmap to Inform Development, Validation and Approval of Digital Mobility Outcomes: The Mobilise-D Approach
Lynn Rochester, Claudia Mazzà, Arne Mueller, Brian Caulfield, Marie McCarthy, Clemens Becker, Ram Miller, Paolo Piraino, Marco Viceconti, Wilhelmus P. Dartee, Judith Garcia-Aymerich, Aida A. Aydemir, Beatrix Vereijken, Valdo Arnera, Nadir Ammour, Michael
Digital Biomarkers.2020; 4(Suppl. 1): 13. CrossRef - Cerebellar contribution to locomotor behavior: A neurodevelopmental perspective
Aaron Sathyanesan, Vittorio Gallo
Neurobiology of Learning and Memory.2019; 165: 106861. CrossRef - A meta-analysis: Parkinson's disease and dual-task walking
Tiphanie E. Raffegeau, Lisa M. Krehbiel, Nyeonju Kang, Frency J. Thijs, Lori J.P. Altmann, James H. Cauraugh, Chris J. Hass
Parkinsonism & Related Disorders.2019; 62: 28. CrossRef - Treadmill exercise intervention improves gait and postural control in alpha-synuclein mouse models without inducing cerebral autophagy
Georgia Minakaki, Fabio Canneva, Frédéric Chevessier, Frederik Bode, Stefanie Menges, Ivanna K. Timotius, Liubov S. Kalinichenko, Holger Meixner, Christian P. Müller, Bjoern M. Eskofier, Nicolas Casadei, Olaf Riess, Rolf Schröder, Jürgen Winkler, Wei Xian
Behavioural Brain Research.2019; 363: 199. CrossRef - Acupuncture Enhances Communication between Cortices with Damaged White Matters in Poststroke Motor Impairment
Xiao Han, Lijun Bai, Chuanzhu Sun, Xuan Niu, Yanzhe Ning, Zhen Chen, Yingying Li, Kuangshi Li, Diyang Lyu, Caihong Fu, Fangyuan Cui, Zhengguang Chen, Zhongjian Tan, Lixin Tang, Yihuai Zou
Evidence-Based Complementary and Alternative Medicine.2019; 2019: 1. CrossRef - Improvement of gait and balance by non-invasive brain stimulation: its use in rehabilitation
Soumya Ghosh
Expert Review of Neurotherapeutics.2019; 19(2): 133. CrossRef - Neural Substrates of Cognitive Motor Interference During Walking; Peripheral and Central Mechanisms
Emad Al-Yahya, Wala’ Mahmoud, Daan Meester, Patrick Esser, Helen Dawes
Frontiers in Human Neuroscience.2019;[Epub] CrossRef - Efficiency of Sensorimotor Networks: Posture and Gait in Young and Older Adults
G. Di Scala, M. Dupuy, E. Guillaud, E. Doat, E. Barse, B. Dillhareguy, F.A.M. Jean, M. Audiffren, J.R. Cazalets, S. Chanraud
Experimental Aging Research.2019; 45(1): 41. CrossRef - Central pattern generators in the brainstem and spinal cord: an overview of basic principles, similarities and differences
Inge Steuer, Pierre A. Guertin
Reviews in the Neurosciences.2019; 30(2): 107. CrossRef - The Effects of Dual‐Task Cognitive Interference and Environmental Challenges on Balance in Huntington's Disease
Nicollette L. Purcell, Jennifer G. Goldman, Bichun Ouyang, Bryan Bernard, Joan A. O'Keefe
Movement Disorders Clinical Practice.2019; 6(3): 202. CrossRef - Descending dopaminergic control of brainstem locomotor circuits
Maxime Fougère, Aurélie Flaive, Alain Frigon, Dimitri Ryczko
Current Opinion in Physiology.2019; 8: 30. CrossRef - Visual Fixation and Continuous Head Rotations Have Minimal Effect on Set-Point Adaptation to Magnetic Vestibular Stimulation
Bryan K. Ward, David S. Zee, Dale C. Roberts, Michael C. Schubert, Nicolas Pérez-Fernández, Jorge Otero-Millan
Frontiers in Neurology.2019;[Epub] CrossRef - Computational modeling of brainstem circuits controlling locomotor frequency and gait
Jessica Ausborn, Natalia A Shevtsova, Vittorio Caggiano, Simon M Danner, Ilya A Rybak
eLife.2019;[Epub] CrossRef - Structure and function of the mesencephalic locomotor region in normal and parkinsonian primates
Brian Lau, Chantal François, Carine Karachi
Current Opinion in Physiology.2019; 8: 121. CrossRef - Ambulation Patterns Post-Discharge in Older Adults Identified as Fall Risk: A Descriptive Pilot Study
Barbara J. King, Roger Brown, Linsey Steege, Haocen Wang, Fang-lin Kuo, Cynthia Brown
Research in Gerontological Nursing.2019; 12(3): 113. CrossRef - Quantification of trunk segmental coordination and head stability in laterally unstable sitting identifies aging and cerebellar ataxia
Koshiro Haruyama, Kenji Kasai, Ryohei Makino, Fumihiko Hoshi, Ken Nishihara
Clinical Biomechanics.2019; 63: 127. CrossRef - Deterioration of Brain Neural Tracts in Elderly Women with Sarcopenia
So Young Kwak, Sang Gyu Kwak, Tae Sang Yoon, Eun Jung Kong, Min Cheol Chang
The American Journal of Geriatric Psychiatry.2019; 27(8): 774. CrossRef - “Special K” Drug on Adolescent Rats: Oxidative Damage and Neurobehavioral Impairments
Sabrina de Carvalho Cartágenes, Luanna Melo Pereira Fernandes, Taiana Cristina Vilhena Sarmento Carvalheiro, Thais Miranda de Sousa, Antônio Rafael Quadros Gomes, Marta Chagas Monteiro, Ricardo Sousa de Oliveira Paraense, Maria Elena Crespo-López, Rafael
Oxidative Medicine and Cellular Longevity.2019; 2019: 1. CrossRef - Current models of speech motor control: A control-theoretic overview of architectures and properties
Benjamin Parrell, Adam C. Lammert, Gregory Ciccarelli, Thomas F. Quatieri
The Journal of the Acoustical Society of America.2019; 145(3): 1456. CrossRef - Falls and Fractures in Diabetes—More than Bone Fragility
Nicklas Højgaard Rasmussen, Jakob Dal
Current Osteoporosis Reports.2019; 17(3): 147. CrossRef - Expression of aggressiveness modulates mesencephalic c-fos activation during a social interaction test in Japanese quail (Coturnix japonica)
Jorge Martin Caliva, Fernando Falkenburger Melleu, Jose Marino-Neto, Raul Hector Marin, Jackelyn Melissa Kembro
Behavioural Brain Research.2019; 367: 221. CrossRef - Positive verbal suggestion optimizes postural control
Bernardo Villa-Sánchez, Mehran Emadi Andani, Giulia Menegaldo, Michele Tinazzi, Mirta Fiorio
Scientific Reports.2019;[Epub] CrossRef - Neuromodulation to improve gait and balance function using a sensory neuroprosthesis in people who report insensate feet – A randomized control cross-over study
Sara R. Koehler-McNicholas, Lori Danzl, Alana Y. Cataldo, Lars I. E. Oddsson, Alfonso Fasano
PLOS ONE.2019; 14(4): e0216212. CrossRef - Selective suppression of the vestibulo-ocular reflex during human locomotion
Haike Dietrich, Max Wuehr
Journal of Neurology.2019; 266(S1): 101. CrossRef - Gait stride-to-stride variability and foot clearance pattern analysis in Idiopathic Parkinson’s Disease and Vascular Parkinsonism
Flora Ferreira, Miguel F. Gago, Estela Bicho, Catarina Carvalho, Nafiseh Mollaei, Lurdes Rodrigues, Nuno Sousa, Pedro Pereira Rodrigues, Carlos Ferreira, João Gama
Journal of Biomechanics.2019; 92: 98. CrossRef - Von der Biomechanik zur Bioinformatik
Philip Eckardt
Osteopathische Medizin.2019; 20(2): 27. CrossRef - Measuring gait speed to better identify prodromal dementia
Giulia Grande, Federico Triolo, Arturo Nuara, Anna-Karin Welmer, Laura Fratiglioni, Davide L. Vetrano
Experimental Gerontology.2019; 124: 110625. CrossRef - Effects of transcranial direct current stimulation (tDCS) on balance improvement: a systematic review and meta-analysis
Maria Clara D. Soares de Moura, Fuad A. Hazime, Luana V. Marotti Aparicio, Luanda A. C. Grecco, André R. Brunoni, Renata Hydeé Hasue
Somatosensory & Motor Research.2019; 36(2): 122. CrossRef - Long-Term Effects of Whole-Body Vibration on Human Gait: A Systematic Review and Meta-Analysis
Matthieu Fischer, Thomas Vialleron, Guillaume Laffaye, Paul Fourcade, Tarek Hussein, Laurence Chèze, Paul-André Deleu, Jean-Louis Honeine, Eric Yiou, Arnaud Delafontaine
Frontiers in Neurology.2019;[Epub] CrossRef - Effective Parameters for Gait Analysis in Experimental Models for Evaluating Peripheral Nerve Injuries in Rats
Ivair Matias Júnior, Priscila Medeiros, Renato Leonardo de Freita, Hilton Vicente-César, José Raniery Ferreira Junior, Hélio Rubens Machado, Rafael Menezes-Reis
Neurospine.2019; 16(2): 305. CrossRef - Freezing of gait in Parkinson’s disease reflects a sudden derangement of locomotor network dynamics
Nicoló G Pozzi, Andrea Canessa, Chiara Palmisano, Joachim Brumberg, Frank Steigerwald, Martin M Reich, Brigida Minafra, Claudio Pacchetti, Gianni Pezzoli, Jens Volkmann, Ioannis U Isaias
Brain.2019; 142(7): 2037. CrossRef - Usual walking and obstacle avoidance are influenced by depressive and anxiety symptoms in patients with Parkinson's disease
Priscila Nóbrega‐Sousa, Diego Orcioli‐Silva, Ellen Lirani‐Silva, Victor Spiandor Beretta, Rodrigo Vitório, Lilian Teresa Bucken Gobbi
Geriatrics & Gerontology International.2019; 19(9): 868. CrossRef - Complexity based measures of postural stability provide novel evidence of functional decline in fragile X premutation carriers
Clodagh O’Keeffe, Laura P. Taboada, Niamh Feerick, Louise Gallagher, Timothy Lynch, Richard B. Reilly
Journal of NeuroEngineering and Rehabilitation.2019;[Epub] CrossRef - Motor-Cognitive Neural Network Communication Underlies Walking Speed in Community-Dwelling Older Adults
Victoria N. Poole, On-Yee Lo, Thomas Wooten, Ikechukwu Iloputaife, Lewis A. Lipsitz, Michael Esterman
Frontiers in Aging Neuroscience.2019;[Epub] CrossRef - Programmable coupled oscillators for synchronized locomotion
Sourav Dutta, Abhinav Parihar, Abhishek Khanna, Jorge Gomez, Wriddhi Chakraborty, Matthew Jerry, Benjamin Grisafe, Arijit Raychowdhury, Suman Datta
Nature Communications.2019;[Epub] CrossRef - Immediate effects of rhythmic auditory stimulation on gait kinematics in Parkinson’s disease ON/OFF medication
Carmen Erra, Ilaria Mileti, Marco Germanotta, Martina Petracca, Isabella Imbimbo, Alessandro De Biase, Stefano Rossi, Diego Ricciardi, Alessandra Pacilli, Enrica Di Sipio, Eduardo Palermo, Anna Rita Bentivoglio, Luca Padua
Clinical Neurophysiology.2019; 130(10): 1789. CrossRef - Patterns of co‐altered brain structure and function underlying neurological soft signs in schizophrenia spectrum disorders
Dusan Hirjak, Mahmoud Rashidi, Stefan Fritze, Alina L. Bertolino, Lena S. Geiger, Zhenxiang Zang, Katharina M. Kubera, Mike M. Schmitgen, Fabio Sambataro, Vince D. Calhoun, Matthias Weisbrod, Heike Tost, Robert C. Wolf
Human Brain Mapping.2019; 40(17): 5029. CrossRef - Spinal Cord Stimulation for Freezing of Gait: From Bench to Bedside
Erich Talamoni Fonoff, Andrea C. de Lima-Pardini, Daniel Boari Coelho, Bernardo Assumpção Monaco, Birajara Machado, Carolina Pinto de Souza, Maria Gabriela dos Santos Ghilardi, Clement Hamani
Frontiers in Neurology.2019;[Epub] CrossRef - Head Anticipation During Locomotion With Auditory Instruction in the Presence and Absence of Visual Input
Felix Dollack, Monica Perusquía-Hernández, Hideki Kadone, Kenji Suzuki
Frontiers in Human Neuroscience.2019;[Epub] CrossRef - Neuroplasticity Modifications Following a Lower‐Limb Amputation: A Systematic Review
Francisco Molina‐Rueda, Cristian Navarro‐Fernández, Alicia Cuesta‐Gómez, Isabel M Alguacil‐Diego, Alberto Molero‐Sánchez, María Carratalá‐Tejada
PM&R.2019; 11(12): 1326. CrossRef - Correlation between selected gait variables and emotion using virtual reality
Young Kim, JunYoung Moon, Nak-Jun Sung, Min Hong
Journal of Ambient Intelligence and Humanized Computing.2019;[Epub] CrossRef - Neural substrates of reduced walking activity after supratentorial stroke: A voxel-based lesion symptom mapping study
Sébastien Baillieul, Charlotte Elsworth-Edelsten, Arnaud Saj, Gilles Allali
Human Movement Science.2019; 67: 102517. CrossRef - Olfactory Stimulation with Japanese Soy Sauce Improves Upper Limb Performance
Yutaka Yano, Yoshihiro Murata, Mutsuo Taniguchi, Fumino Okutani, Masahiro Yamaguchi, Hideto Kaba
Occupational Therapy International.2019; 2019: 1. CrossRef - Botulinum toxin A injection into the entopeduncular nucleus improves dynamic locomotory parameters in hemiparkinsonian rats
Adrianna R. Tsang, Nagalingam Rajakumar, Mandar S. Jog, David I. Finkelstein
PLOS ONE.2019; 14(10): e0223450. CrossRef - Functional and Brain Activation Changes Following Specialized Upper-Limb Exercise in Parkinson’s Disease
Luca Valerio Messa, Federica Ginanneschi, Davide Momi, Lucia Monti, Carla Battisti, David Cioncoloni, Barbara Pucci, Emiliano Santarnecchi, Alessandro Rossi
Frontiers in Human Neuroscience.2019;[Epub] CrossRef - Neuroimaging advances in Parkinson's disease with freezing of gait: A systematic review
Komal Bharti, Antonio Suppa, Silvia Tommasin, Alessandro Zampogna, Sara Pietracupa, Alfredo Berardelli, Patrizia Pantano
NeuroImage: Clinical.2019; 24: 102059. CrossRef - Effects of supraspinal feedback on human gait: rhythmic auditory distortion
Arturo Forner-Cordero, João Pedro Pinho, Guilherme Umemura, João Carlos Lourenço, Bruno Mezêncio, Cinthia Itiki, Hermano Igo Krebs
Journal of NeuroEngineering and Rehabilitation.2019;[Epub] CrossRef - Cortical disconnection of the ipsilesional primary motor cortex is associated with gait speed and upper extremity motor impairment in chronic left hemispheric stroke
Denise M. Peters, Julius Fridriksson, Jill C. Stewart, Jessica D. Richardson, Chris Rorden, Leonardo Bonilha, Addie Middleton, Ezequiel Gleichgerrcht, Stacy L. Fritz
Human Brain Mapping.2018; 39(1): 120. CrossRef - Effects of transcranial direct current stimulation over the supplementary motor area body weight-supported treadmill gait training in hemiparetic patients after stroke
Atsushi Manji, Kazu Amimoto, Tadamitsu Matsuda, Yoshiaki Wada, Akira Inaba, Sangkyun Ko
Neuroscience Letters.2018; 662: 302. CrossRef - Gender-related differences in neural responses to gaming cues before and after gaming: implications for gender-specific vulnerabilities to Internet gaming disorder
Guangheng Dong, Lingxiao Wang, Xiaoxia Du, Marc N Potenza
Social Cognitive and Affective Neuroscience.2018; 13(11): 1203. CrossRef - Stem Cell Transplantation and Physical Exercise in Parkinson’s Disease, a Literature Review of Human and Animal Studies
Jaison Daniel Cucarián Hurtado, Jenny Paola Berrío Sánchez, Ramiro Barcos Nunes, Alcyr Alves de Oliveira
Stem Cell Reviews and Reports.2018; 14(2): 166. CrossRef - Postural control and the relation with cervical sensorimotor control in patients with idiopathic adult-onset cervical dystonia
J. De Pauw, R. Mercelis, A. Hallemans, G. Van Gils, S. Truijen, P. Cras, W. De Hertogh
Experimental Brain Research.2018; 236(3): 803. CrossRef - Efecto de un programa de rehabilitación mediante entrenamiento en tapiz rodante con tareas duales en las alteraciones del equilibrio y la marcha en el daño cerebral adquirido
Á. Aguilera-Rubio, P. Fernández-González, F. Molina-Rueda, A. Cuesta-Gómez
Rehabilitación.2018; 52(2): 107. CrossRef - Noisy vestibular stimulation increases gait speed in normals and in bilateral vestibulopathy
Shinichi Iwasaki, Chisato Fujimoto, Naoya Egami, Makoto Kinoshita, Fumiharu Togo, Yoshiharu Yamamoto, Tatsuya Yamasoba
Brain Stimulation.2018; 11(4): 709. CrossRef - Paradoxical kinesia induced by appetitive 50-kHz ultrasonic vocalizations in rats depends on glutamatergic mechanisms in the inferior colliculus
Luan Castro Tonelli, Markus Wöhr, Rainer Schwarting, Liana Melo-Thomas
Neuropharmacology.2018; 135: 172. CrossRef - Managing Gait, Balance, and Posture in Parkinson’s Disease
Bettina Debû, Clecio De Oliveira Godeiro, Jarbas Correa Lino, Elena Moro
Current Neurology and Neuroscience Reports.2018;[Epub] CrossRef - Vestibular signals in primate cortex for self-motion perception
Yong Gu
Current Opinion in Neurobiology.2018; 52: 10. CrossRef - What If Low Back Pain Is the Most Prevalent Parkinsonism in the World?
Jesse V. Jacobs, Sharon M. Henry, Fay B. Horak
Frontiers in Neurology.2018;[Epub] CrossRef - The Dorsal Column Lesion Model of Spinal Cord Injury and Its Use in Deciphering the Neuron‐Intrinsic Injury Response
Callan L. Attwell, Mike van Zwieten, Joost Verhaagen, Matthew R. J. Mason
Developmental Neurobiology.2018; 78(10): 926. CrossRef - Exergames Inherently Contain Cognitive Elements as Indicated by Cortical Processing
Phillipp Anders, Tim Lehmann, Helen Müller, Karoline B. Grønvik, Nina Skjæret-Maroni, Jochen Baumeister, Beatrix Vereijken
Frontiers in Behavioral Neuroscience.2018;[Epub] CrossRef - Phase matters: A role for the subthalamic network during gait
Gabriele Arnulfo, Nicolò Gabriele Pozzi, Chiara Palmisano, Alice Leporini, Andrea Canessa, Joachim Brumberg, Gianni Pezzoli, Cordula Matthies, Jens Volkmann, Ioannis Ugo Isaias, Nader Pouratian
PLOS ONE.2018; 13(6): e0198691. CrossRef - Social jetlag impairs balance control
Guilherme Silva Umemura, João Pedro Pinho, Bruno da Silva Brandão Gonçalves, Fabianne Furtado, Arturo Forner-Cordero
Scientific Reports.2018;[Epub] CrossRef - The consequence of cerebral small vessel disease: Linking brain atrophy to motor impairment in the elderly
Ning Su, Xinyu Liang, Fei‐Fei Zhai, Li‐Xin Zhou, Jun Ni, Ming Yao, Feng Tian, Shu‐Yang Zhang, Zheng‐Yu Jin, Li‐Ying Cui, Gaolang Gong, Yi‐Cheng Zhu
Human Brain Mapping.2018; 39(11): 4452. CrossRef - Extrapyramidal deficits in ALS: a combined biomechanical and neuroimaging study
Maryse Feron, Annabelle Couillandre, Eya Mseddi, Nicolas Termoz, Malek Abidi, Eric Bardinet, Daniel Delgadillo, Timothée Lenglet, Giorgia Querin, Marie-Laure Welter, Nadine Le Forestier, François Salachas, Gaelle Bruneteau, Maria del Mar Amador, Rabab Deb
Journal of Neurology.2018; 265(9): 2125. CrossRef - Brain responses during strategic online gaming of varying proficiencies: Implications for better gaming
Min Wang, Guangheng Dong, Lingxiao Wang, Hui Zheng, Marc N. Potenza
Brain and Behavior.2018;[Epub] CrossRef - Adaptations to Postural Perturbations in Patients With Freezing of Gait
Esther M. J. Bekkers, Sam Van Rossom, Elke Heremans, Kim Dockx, Surendar Devan, Sabine M. P. Verschueren, Alice Nieuwboer
Frontiers in Neurology.2018;[Epub] CrossRef - Influence of the intensity of galvanic vestibular stimulation and cutaneous stimulation on the soleus H-reflex in healthy individuals
Yohei Okada, Tomoyuki Shiozaki, Junji Nakamura, Yuji Azumi, Miyo Inazato, Moe Ono, Honoka Kondo, Miyuki Sugitani, Akiyoshi Matsugi
NeuroReport.2018; 29(13): 1135. CrossRef - Role of medical ozone in attenuating age-related changes in the rat cerebellum
Wael B Elkholy, Marwa A Al-Gholam
Microscopy.2018; 67(4): 214. CrossRef - A bio-inspired self-responding emotional behavior system for virtual creatures
Diana G. Gómez-Martínez, Jonathan-Hernando Rosales, Vianney Muñoz-Jiménez, Félix Ramos, Marco Ramos
Biologically Inspired Cognitive Architectures.2018; 26: 26. CrossRef - Balancing between the two: Are freezing of gait and postural instability in Parkinson’s disease connected?
E.M.J. Bekkers, B.W. Dijkstra, E. Heremans, S.M.P. Verschueren, B.R. Bloem, A. Nieuwboer
Neuroscience & Biobehavioral Reviews.2018; 94: 113. CrossRef - Effects of spinal cord stimulation on postural control in Parkinson's disease patients with freezing of gait
Andrea Cristina de Lima-Pardini, Daniel Boari Coelho, Carolina Pinto Souza, Carolina Oliveira Souza, Maria Gabriela dos Santos Ghilardi, Tiago Garcia, Mariana Voos, Matija Milosevic, Clement Hamani, Luis Augusto Teixeira, Erich Talamoni Fonoff
eLife.2018;[Epub] CrossRef - The Balance of Sleep: Role of the Vestibular Sensory System
Stephane Besnard, Brahim Tighilet, Christian Chabbert, Martin Hitier, Joseph Toulouse, Anne Legall, Marie-Laure Machado, Paul F. Smith
Sleep Medicine Reviews.2018;[Epub] CrossRef - Neural Mechanism of Human Gait and Postural Control
Hiroaki Fujimoto, Ichiro Miyai
The Japanese Journal of Rehabilitation Medicine.2018; 55(9): 724. CrossRef - Targeting the pedunculopontine nucleus in Parkinson's disease: Time to go back to the drawing board
Roger L. Albin, D. James Surmeier, Cecilia Tubert, Martin Sarter, Martijn L.T.M. Müller, Nicolaas I. Bohnen, William T. Dauer
Movement Disorders.2018; 33(12): 1871. CrossRef - Vestibular System and Self-Motion
Zhixian Cheng, Yong Gu
Frontiers in Cellular Neuroscience.2018;[Epub] CrossRef - Physical exercise enhances adult cortical plasticity in a neonatal rat model of hypoxic-ischemic injury: Evidence from BOLD-fMRI and electrophysiological recordings
Sun Young Chae, Jun Ho Jang, Geun Ho Im, Ji-Hyun Jeong, Won-Beom Jung, Sukjin Ko, Hyesoo Jie, Ji Hye Kim, Yun Sil Chang, Seungsoo Chung, Ki-Soo Kim, Jung Hee Lee
NeuroImage.2018;[Epub] CrossRef - Detection and Diagnosis of Paralysis Agitans
Xiao Fan, Wanrong Sun, Aifeng Ren, Dou Fan, Nan Zhao, Daniyal Haider, Xiaodong Yang, Qammer H. Abbasi
IEEE Access.2018; 6: 73023. CrossRef - Effect of Treadmill Training With Eyes Open and Closed on Knee Proprioception, Functional Balance and Mobility in Children With Spastic Diplegia
Samah Attia El Shemy
Annals of Rehabilitation Medicine.2018; 42(6): 854. CrossRef - Magnetic Vestibular Stimulation (MVS) As a Technique for Understanding the Normal and Diseased Labyrinth
Bryan K. Ward, Jorge Otero-Millan, Prem Jareonsettasin, Michael C. Schubert, Dale C. Roberts, David S. Zee
Frontiers in Neurology.2017;[Epub] CrossRef - Postural Control in Bilateral Vestibular Failure: Its Relation to Visual, Proprioceptive, Vestibular, and Cognitive Input
Andreas Sprenger, Jann F. Wojak, Nico M. Jandl, Christoph Helmchen
Frontiers in Neurology.2017;[Epub] CrossRef - Diabetic Neuropathy and Gait: A Review
Uazman Alam, David R. Riley, Ravinder S. Jugdey, Shazli Azmi, Satyan Rajbhandari, Kristiaan D’Août, Rayaz A. Malik
Diabetes Therapy.2017; 8(6): 1253. CrossRef - Freezing of gait is associated with cortical thinning in mesial frontal cortex
Miroslav Vastik, Pavel Hok, Jan Valosek, Petr Hlustik, Katerina Mensikova, Petr Kanovsky
Biomedical Papers.2017; 161(4): 389. CrossRef - Cerebral Small Vessel Disease Burden Is Associated with Motor Performance of Lower and Upper Extremities in Community-Dwelling Populations
Ning Su, Fei-Fei Zhai, Li-Xin Zhou, Jun Ni, Ming Yao, Ming-Li Li, Zheng-Yu Jin, Gao-Lang Gong, Shu-Yang Zhang, Li-Ying Cui, Feng Tian, Yi-Cheng Zhu
Frontiers in Aging Neuroscience.2017;[Epub] CrossRef - Cough-Anal Reflex May Be the Expression of a Pre-Programmed Postural Action
Paolo Cavallari, Francesco Bolzoni, Roberto Esposti, Carlo Bruttini
Frontiers in Human Neuroscience.2017;[Epub] CrossRef - The effect of visual information on gait parameters with induced ankle muscle fatigue
Hye Rim Suh, Jin-Hee Hwang, Su-Young Lee
Physical Therapy Rehabilitation Science.2017; 6(3): 140. CrossRef - Construct Validity and Reliability of the SARA Gait and Posture Sub-scale in Early Onset Ataxia
Tjitske F. Lawerman, Rick Brandsma, Renate J. Verbeek, Johannes H. van der Hoeven, Roelineke J. Lunsing, Hubertus P. H. Kremer, Deborah A. Sival
Frontiers in Human Neuroscience.2017;[Epub] CrossRef - Striatal But Not Extrastriatal Dopamine Receptors Are Critical to Dopaminergic Motor Stimulation
Yuhan Wang, Fu-Ming Zhou
Frontiers in Pharmacology.2017;[Epub] CrossRef
- Correlations between plantar pressure and postural balance in healthy subjects and their comparison according to gender and limb dominance: A cross-sectional descriptive study
- Neurodegeneration with Brain Iron Accumulation: Diagnosis and Management
- Penelope Hogarth
- J Mov Disord. 2015;8(1):1-13. Published online January 31, 2015
- DOI: https://doi.org/10.14802/jmd.14034
- 39,766 View
- 991 Download
- 125 Citations
-
Abstract
PDF
- Neurodegeneration with brain iron accumulation (NBIA) encompasses a group of inherited disorders that share the clinical features of an extrapyramidal movement disorder accompanied by varying degrees of intellectual disability and abnormal iron deposition in the basal ganglia. The genetic basis of ten forms of NBIA is now known. The clinical features of NBIA range from rapid global neurodevelopmental regression in infancy to mild parkinsonism with minimal cognitive impairment in adulthood, with wide variation seen between and within the specific NBIA sub-type. This review describes the clinical presentations, imaging findings, pathologic features, and treatment considerations for this heterogeneous group of disorders.
-
Citations
Citations to this article as recorded by- Missing heritability of Wilson disease: a search for the uncharacterized mutations
Shubhrajit Roy, Sampurna Ghosh, Jharna Ray, Kunal Ray, Mainak Sengupta
Mammalian Genome.2023; 34(1): 1. CrossRef - A Mild Form of Neurodegeneration with Brain Iron Accumulation attributed to Coenzyme A Synthase Mutation
Narges Hashemi, Reza Nejad Shahrokh Abadi, Afagh Alavi, Ali Reza Tavasoli, Mohammad Rohani
Movement Disorders Clinical Practice.2023; 10(2): 331. CrossRef - Neurodegeneration with brain iron accumulation: a case series highlighting phenotypic and genotypic diversity in 20 Indian families
Haseena Sait, Somya Srivastava, Manmohan Pandey, Deepak Ravichandran, Anju Shukla, Kausik Mandal, Deepti Saxena, Arya Shambhavi, Purvi Majethia, Lakshmi Priya Rao, Suvasini Sharma, Shubha R. Phadke, Amita Moirangthem
neurogenetics.2023; 24(2): 113. CrossRef - Status Epilepticus in Coenzyme A Synthase Protein-Associated Neurodegeneration - Expanding the Clinical Phenotype
Valaparambil Karthika Ajit, Prabhu Selvaraj, KP Divya, Bejoy Thomas, Ramshekhar N. Menon, Soumya Sundaram
Indian Journal of Pediatrics.2023; 90(5): 519. CrossRef - Exploring the genetic and genomic connection underlying neurodegeneration with brain iron accumulation and the risk for Parkinson’s disease
Pilar Alvarez Jerez, Jose Luis Alcantud, Lucia de los Reyes-Ramírez, Anni Moore, Clara Ruz, Francisco Vives Montero, Noela Rodriguez-Losada, Prabhjyot Saini, Ziv Gan-Or, Chelsea X. Alvarado, Mary B. Makarious, Kimberley J. Billingsley, Cornelis Blauwendra
npj Parkinson's Disease.2023;[Epub] CrossRef - Substance abuse and neurodegenerative diseases: focus on ferroptosis
Cheng Guo, Lei Chen, Yun Wang
Archives of Toxicology.2023; 97(6): 1519. CrossRef - Clinical, imaging and genetic profile of twenty-four patients with pantothenate kinase-associated neurodegeneration (PKAN)- A single centre study from India
Neeharika Sriram, Vikram V. Holla, Riyanka Kumari, Nitish Kamble, Jitender Saini, Rohan Mahale, Manjunath Netravathi, Hansashree Padmanabha, Vykuntaraju K. Gowda, Rajani Battu, Akhilesh Pandey, Ravi Yadav, Babylakshmi Muthusamy, Pramod Kumar Pal
Parkinsonism & Related Disorders.2023; 111: 105409. CrossRef - Heme: The Lord of the Iron Ring
Vanessa Azevedo Voltarelli, Rodrigo W. Alves de Souza, Kenji Miyauchi, Carl J. Hauser, Leo Edmond Otterbein
Antioxidants.2023; 12(5): 1074. CrossRef - Beta-propeller protein-associated neurodegeneration: A clinical update with a case report
Moustafa A. Mansour, Yehia Moawad, Hassan Ali
eNeurologicalSci.2023; 31: 100469. CrossRef - The Effects of Modulators of the Coenzyme A Biosynthesis System on Metabolic Stress and the Glutathione System in the CNS in Aluminum Neurotoxicosis
D. S. Semenovich, V. A. Gurinovich, E. P. Lukienko, I. N. Katkovskaya, O. V. Titko, N. P. Kanunnikova, A. G. Moiseenok
Neurochemical Journal.2023; 17(1): 65. CrossRef - Late‐Onset Beta‐Propeller Protein‐Associated Neurodegeneration: A Case Report
Roger Collet‐Vidiella, Gonzalo Olmedo‐Saura, Iñigo Ruiz‐Barrio, Ana Martínez‐Viguera, Benjamin Rodriguez‐Santiago, Sara Bernal, Jaime Kulisevsky, Javier Pagonabarraga
Movement Disorders Clinical Practice.2023; 10(8): 1211. CrossRef - The first reports of FA2H-associated neurodegeneration from two unrelated Iranian families
Narges Hashemi, Reza Nejad Shahrokh Abadi, Afagh Alavi, Mohammad Rohani, Aida Ghasemi, Ali Reza Tavasoli
Neurological Sciences.2023; 44(12): 4359. CrossRef - Autosomal Dominant MPAN: Mosaicism Expands the Clinical Spectrum to Atypical Late‐Onset Phenotypes
Chloé Angelini, Christelle Marie Durand, Patricia Fergelot, Julie Deforges, Anne Vital, Patrice Menegon, Elizabeth Sarrazin, Rémi Bellance, Stéphane Mathis, Victoria Gonzalez, Mathilde Renaud, Solène Frismand, Emmanuelle Schmitt, Marie Rouanet, Lydie Burg
Movement Disorders.2023; 38(11): 2103. CrossRef - Olfactory status in neurodegeneration with brain iron accumulation disorders
Elahe Amini, Mohammad Rohani, Maryam Jalessi, Zahra Azad, Franco Valzania, Francesco Cavallieri, Mohammad Farhadi, Zeinab Gholibeigian
Neurological Sciences.2023;[Epub] CrossRef - Neurodegeneration with Brain Iron Accumulation Disorders and Retinal Neurovascular Structure
Elahe Amini, Mohammad Rohani, Alfonso Fasano, Zahra Azad, Shahnaz Miri, Seyed Amir Hassan Habibi, Maziar Emamikhah, Reza Mirshahi, Mohammad Taghi Joghataei, Zeinab Gholibeigian, Khalil Ghasemi Falavarjani
Movement Disorders.2023;[Epub] CrossRef - Femur Fractures in 5 Individuals With Pantothenate Kinase-associated Neurodegeneration: The Role of Dystonia and Suggested Management
Laken Behrndt, Allison Gregory, Katrina Wakeman, Alison Freed, Jenny L. Wilson, Robert Spaull, Manju A. Kurian, Santosh Mordekar, James A. Fernandes, Susan J. Hayflick, Penelope Hogarth, Scott Yang
Journal of Pediatric Orthopaedics.2023;[Epub] CrossRef - Transcranial Sonography in Neurodegeneration with Brain Iron Accumulation Disorders
Seyed Amir Hassan Habibi, Sharmin Aghavali, Zahra Azad, Elahe Amini, Masoumeh Falah, Zeinab Gholibeigian, Narges Yazdi, Maziar Emamikhah, Mohammad Rohani
Clinical Neurology and Neurosurgery.2023; : 108074. CrossRef - Estimation of Ambulation and Survival in Neurodegeneration with Brain Iron Accumulation Disorders
Elahe Amini, Mohammad Rohani, Anthony E. Lang, Zahra Azad, Seyed Amir Hassan Habibi, Afagh Alavi, Gholamali Shahidi, Maziar Emamikhah, Ahmad Chitsaz
Movement Disorders Clinical Practice.2023;[Epub] CrossRef - Treatment of Pantothenate-Kinase Neurodegeneration With Baclofen, Botulinum Toxin, and Deferiprone: A Case Report
Marya Hameed, Fatima Siddiqui, Muhammad Khuzzaim Khan, Sindhura Tadisetty, Prasanna Kumar Gangishetti
Brain & Neurorehabilitation.2023;[Epub] CrossRef - Neurodegeneration with Brain Iron Accumulation and a Brief Report of the Disease in Iran
Reza Hajati, Maziar Emamikhah, Fardad Danaee Fard, Mohammad Rohani, Afagh Alavi
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.2022; 49(3): 338. CrossRef - A Practical Approach to Early-Onset Parkinsonism
Giulietta M. Riboldi, Emanuele Frattini, Edoardo Monfrini, Steven J. Frucht, Alessio Di Fonzo
Journal of Parkinson's Disease.2022; 12(1): 1. CrossRef - Parkinsonism and tremor syndromes
Steven Bellows, Joseph Jankovic
Journal of the Neurological Sciences.2022; 433: 120018. CrossRef - Aceruloplasminemia: MRI and Biochemical Profile Clue to Early Diagnosis in an Adolescent
Swapnil Sheth, Seema Sud, Tarvinder B. S. Buxi, Salil Bhargava, Ratna Dua Puri, Sapna Sandal, C.S. Agrawal
Journal of Pediatric Neurology.2022; 20(02): 133. CrossRef - Lifetime risk of autosomal recessive neurodegeneration with brain iron accumulation (NBIA) disorders calculated from genetic databases
Hana Kolarova, Jing Tan, Tim M. Strom, Thomas Meitinger, Matias Wagner, Thomas Klopstock
eBioMedicine.2022; 77: 103869. CrossRef - Two cases with mitochondrial membrane protein-associated neurodegeneration: genetic features and long-term clinical follow-up
Sevcan Mercan, Sibel Aylin Ugur Iseri, Remzi Yigiter, Nihan Hande Akcakaya, Esen Saka, Zuhal Yapici
Neurocase.2022; 28(1): 37. CrossRef - CHARACTERISTIC UPPER LIMB DYSTONIA PATTERN AS A CORRELATE TO THE 'EYE OF TIGER' MRI SIGN.
Akash Chheda, Dnyaneshwar V Jadhav, Sangeeta Ravat
GLOBAL JOURNAL FOR RESEARCH ANALYSIS.2022; : 28. CrossRef - A case of senile-onset progressive hemiballism and cognitive decline with diffuse brain iron accumulations
I-Ting Lin, Ni-Chung Lee, Sung-Pin Fan, Chang-Jin Huang, PoWei Cheng, Jyh-Horng Chen, Chin-Hsien Lin
Parkinsonism & Related Disorders.2022; 98: 114. CrossRef - A Case of MPAN with “Eye of the Tiger Sign,” Mimicking PKAN
Masoumeh Dehghan Manshadi, Mohammd Rohani, Ali Rezaei, Omid Aryani
Movement Disorders Clinical Practice.2022; 9(5): 693. CrossRef - Spinal cord stimulation for freezing of gait in Parkinson's disease and progressive supranuclear palsy: a case series
Vladislav V. Kovalev, Ekaterina V. Bril, Maksim S. Semenov, Yury A. Seliverstov, Levan T. Lepsveridze
Almanac of Clinical Medicine.2022; 50(5): 315. CrossRef - Early Neuroimaging Markers in β Propeller Protein-Associated Neurodegeneration
L. Chiapparini, G. Zorzi
American Journal of Neuroradiology.2022; 43(12): 1815. CrossRef - Deletion of ferritin H in neurons counteracts the protective effect of melatonin against traumatic brain injury‐induced ferroptosis
Tongyu Rui, Haochen Wang, Qianqian Li, Ying Cheng, Yuan Gao, Xuexian Fang, Xuying Ma, Guang Chen, Cheng Gao, Zhiya Gu, Shunchen Song, Jian Zhang, Chunling Wang, Zufeng Wang, Tao Wang, Mingyang Zhang, Junxia Min, Xiping Chen, Luyang Tao, Fudi Wang, Chengli
Journal of Pineal Research.2021;[Epub] CrossRef - Correlation of dystonia severity and iron accumulation in Rett syndrome
Tz-Yun Jan, Lee-Chin Wong, Ming-Tao Yang, Chien-Feng Judith Huang, Chia-Jui Hsu, Steven Shinn-Forng Peng, Wen-Yih Isaac Tseng, Wang-Tso Lee
Scientific Reports.2021;[Epub] CrossRef - The Case of a Patient with Pantothenate Kinase-Associated Neurodegeneration Presenting with a Prolonged History of Stuttering Speech and a Misdiagnosis of Parkinson’s Disease
Prashant A Natteru, Juebin Huang
Journal of Movement Disorders.2021; 14(1): 86. CrossRef - Retrospective analysis of 17 patients with mitochondrial membrane protein-associated neurodegeneration diagnosed in Russia
Peter Sparber, Tatiana Krylova, Svetlana Repina, Nina Demina, Galina Rudenskaya, Inna Sharkova, Artem Sharkov, Vitaly Kadyshev, Ilya Kanivets, Sergey Korostelev, Ekaterina Pomerantseva, Vladimir Kaimonov, Svetlana Mikhailova, Ekaterina Zakharova, Mikhail
Parkinsonism & Related Disorders.2021; 84: 98. CrossRef - Arching deep brain stimulation in dystonia types
Han-Joon Kim, Beomseok Jeon
Journal of Neural Transmission.2021; 128(4): 539. CrossRef -
WDR45 Gene and Its Role in Pediatric Epilepsies
Federica Filosco, Sebastiano Billone, Ausilia Collotta, Tiziana Timpanaro, Monica Tosto, Raffaele Falsaperla, Silvia Marino, Antonio Zanghì, Andrea D. Praticò
Journal of Pediatric Neurology.2021;[Epub] CrossRef - Emerging Disease-Modifying Therapies in Neurodegeneration With Brain Iron Accumulation (NBIA) Disorders
Vassilena Iankova, Ivan Karin, Thomas Klopstock, Susanne A. Schneider
Frontiers in Neurology.2021;[Epub] CrossRef - Neurodegeneration with brain iron accumulation: Characterization of clinical, radiological, and genetic features of pediatric patients from Southern India
Naveen Kumar Bhardwaj, Vykuntaraju K. Gowda, Jitendra Saini, Ashwin Vivek Sardesai, Rashmi Santhoshkumar, Anita Mahadevan
Brain and Development.2021; 43(10): 1013. CrossRef - Autophagic defects observed in fibroblasts from a patient with β‐propeller protein‐associated neurodegeneration
Jae‐Hyeok Lee, Sang Ook Nam, Eun Kyoung Kim, Jin‐Hong Shin, Seung Hwan Oh, Dongryeol Ryu, Hye Eun Lee, Ji Young Mun
American Journal of Medical Genetics Part A.2021; 185(12): 3866. CrossRef - Consensus clinical management guideline for beta‐propeller protein‐associated neurodegeneration
Jenny L Wilson, Allison Gregory, Manju A Kurian, Ittai Bushlin, Fanny Mochel, Lisa Emrick, Laura Adang, Penelope Hogarth, Susan J Hayflick
Developmental Medicine & Child Neurology.2021; 63(12): 1402. CrossRef - Findings of Magnetic Resonance and Dopamine Transporter Imaging in Beta-Propeller Protein-Associated Neurodegeneration
Seong Ho Jeong
Journal of the Korean Neurological Association.2021; 39(3): 239. CrossRef - An Eye on Movement Disorders
Duncan Wilson, Mark Hallett, Tim Anderson
Movement Disorders Clinical Practice.2021; 8(8): 1168. CrossRef - Towards Precision Therapies for Inherited Disorders of Neurodegeneration with Brain Iron Accumulation
Robert V.V. Spaull, Audrey K.S. Soo, Penelope Hogarth, Susan J. Hayflick, Manju A. Kurian
Tremor and Other Hyperkinetic Movements.2021;[Epub] CrossRef - Novel C19orf12 loss-of-function variant leading to neurodegeneration with brain iron accumulation
Antonia Lefter, Iulia Mitrea, Dan Mitrea, Vasilica Plaiasu, Aida Bertoli-Avella, Christian Beetz, Liviu Cozma, Delia Tulbă, Cristina Elena Mitu, Bogdan Ovidiu Popescu
Neurocase.2021; 27(6): 481. CrossRef - Early-onset presentation of a new subtype of β-Propeller protein-associated neurodegeneration (BPAN) caused by a de novo WDR45 deletion in a 6 year-old female patient
Stephanie Christoforou, Kyproula Christodoulou, Violetta Anastasiadou, Paola Nicolaides
European Journal of Medical Genetics.2020; 63(3): 103765. CrossRef - A rare PANK2 deletion in the first north African patient affected with pantothenate kinase associated neurodegeneration
Stephanie Efthymiou, Yamna Kriouile, Vincenzo Salpietro, Rhouda Hajar, Zouiri Ghizlane, Kshitij Mankad, Mohamed El Khorassani, Mhammed Aguennouz, Henry Houlden, Sarah Wiethoff
Journal of the Neurological Sciences.2020; 410: 116639. CrossRef - Chemical Chaperones as Novel Drugs for Parkinson’s Disease
Jordi Pujols, Samuel Peña-Díaz, Irantzu Pallarès, Salvador Ventura
Trends in Molecular Medicine.2020; 26(4): 408. CrossRef - A case of novel WDR45 mutation with beta-propeller protein-associated neurodegeneration (BPAN) presenting asymmetrical extrapyramidal signs
Ryota Sato, Michiaki Koga, Kazuhiro Iwama, Tsuyoshi Mizuguchi, Naomichi Matsumoto, Takashi Kanda
Rinsho Shinkeigaku.2020; 60(5): 317. CrossRef - Atypical pantothenate kinase-associated neurodegeneration with PANK2 mutations : clinical description and a review of the literature
Si Pan, Chenkai Zhu
Neurocase.2020; 26(3): 175. CrossRef - The roles of iron and HFE genotype in neurological diseases
Yunsung Kim, James R. Connor
Molecular Aspects of Medicine.2020; 75: 100867. CrossRef - L'acéruléoplasminémie héréditaire, une pathologie à ne pas méconnaître
H. Lobbes, Q. Reynaud, S. Mainbourg, J-C. Lega, I. Durieu, S. Durupt
La Revue de Médecine Interne.2020; 41(11): 769. CrossRef - Atypical brain MRI in neurological Wilson disease
Jong Hyeon Ahn, Joomee Song, Inyoung Choi, Ji Sun Kim, Jin Whan Cho, Jinyoung Youn
Parkinsonism & Related Disorders.2020; 78: 70. CrossRef - Clinical features and blood iron metabolism markers in children with beta-propeller protein associated neurodegeneration
Anezka Belohlavkova, Katalin Sterbova, Cornelia Betzler, Stuve Burkhard, Axel Panzer, Markus Wolf, Petra Lassuthova, Marketa Vlckova, Martin Kyncl, Barbora Benova, Alena Jahodova, Martin Kudr, Maria Goerg, Petr Dusek, Pavel Seeman, Gerhard Kluger, Pavel K
European Journal of Paediatric Neurology.2020;[Epub] CrossRef - Loss of tyrosine hydroxylase, motor deficits and elevated iron in a mouse model of phospholipase A2G6-associated neurodegeneration (PLAN)
Michael Minkley, Patrick MacLeod, Christopher K. Anderson, Raad Nashmi, Patrick B. Walter
Brain Research.2020; 1748: 147066. CrossRef - Nanotechnology-based Targeting of Neurodegenerative Disorders: A Promising Tool for Efficient Delivery of Neuromedicines
Kuldeep Rajpoot
Current Drug Targets.2020; 21(8): 819. CrossRef - Brain MRI Pattern Recognition in Neurodegeneration With Brain Iron Accumulation
Jae-Hyeok Lee, Ji Young Yun, Allison Gregory, Penelope Hogarth, Susan J. Hayflick
Frontiers in Neurology.2020;[Epub] CrossRef - Molecular Defects in Friedreich’s Ataxia: Convergence of Oxidative Stress and Cytoskeletal Abnormalities
Frances M. Smith, Daniel J. Kosman
Frontiers in Molecular Biosciences.2020;[Epub] CrossRef - Neuroimaging of Basal Ganglia in Neurometabolic Diseases in Children
Justyna Paprocka, Magdalena Machnikowska-Sokołowska, Katarzyna Gruszczyńska, Ewa Emich-Widera
Brain Sciences.2020; 10(11): 849. CrossRef - Eye of tiger sign in patient with extrapyramidal syndrome - unique case report
Martin Daniš, Juraj Cisár, Georgi Krastev
Neurologie pro praxi.2020; 21(4): 319. CrossRef - Early onset developmental delay and epilepsy in pediatric patients with WDR45 variants
Hongbo Chen, Yanyan Qian, Sha Yu, Deyong Xiao, Xiao Guo, Qing Wang, Lili Hao, Kai Yan, Yulan Lu, Xinran Dong, Wenhao Zhou, Bingbing Wu, Shuizhen Zhou, Huijun Wang
European Journal of Medical Genetics.2019; 62(2): 149. CrossRef - A new NBIA patient from Turkey with homozygous C19ORF12 mutation
Çiğdem Seher Kasapkara, Leyla Tümer, Allison Gregory, Fatih Ezgü, Aslı İnci, Betül Emine Derinkuyu, Rachel Fox, Caleb Rogers, Susan Hayflick
Acta Neurologica Belgica.2019; 119(4): 623. CrossRef - Substantia Nigra Swelling and Dentate Nucleus T2 Hyperintensity May Be Early Magnetic Resonance Imaging Signs of β‐Propeller Protein‐Associated Neurodegeneration
Camilla Russo, Anna Ardissone, Elena Freri, Serena Gasperini, Marco Moscatelli, Giovanna Zorzi, Celeste Panteghini, Barbara Castellotti, Barbara Garavaglia, Nardo Nardocci, Luisa Chiapparini
Movement Disorders Clinical Practice.2019; 6(1): 51. CrossRef - A Golgi-targeting fluorescent probe for labile Fe(ii) to reveal an abnormal cellular iron distribution induced by dysfunction of VPS35
Tasuku Hirayama, Masatoshi Inden, Hitomi Tsuboi, Masato Niwa, Yasuhiro Uchida, Yuki Naka, Isao Hozumi, Hideko Nagasawa
Chemical Science.2019; 10(5): 1514. CrossRef - Iron in Neurodegeneration – Cause or Consequence?
Alain Ndayisaba, Christine Kaindlstorfer, Gregor K. Wenning
Frontiers in Neuroscience.2019;[Epub] CrossRef - Aceruloplasminemia: A Severe Neurodegenerative Disorder Deserving an Early Diagnosis
Giacomo Marchi, Fabiana Busti, Acaynne Lira Zidanes, Annalisa Castagna, Domenico Girelli
Frontiers in Neuroscience.2019;[Epub] CrossRef - FAHN/SPG35: a narrow phenotypic spectrum across disease classifications
Tim W Rattay, Tobias Lindig, Jonathan Baets, Katrien Smets, Tine Deconinck, Anne S Söhn, Konstanze Hörtnagel, Kathrin N Eckstein, Sarah Wiethoff, Jennifer Reichbauer, Marion Döbler-Neumann, Ingeborg Krägeloh-Mann, Michaela Auer-Grumbach, Barbara Plecko, A
Brain.2019; 142(6): 1561. CrossRef - Juvenile parkinsonism: Differential diagnosis, genetics, and treatment
Nicki Niemann, Joseph Jankovic
Parkinsonism & Related Disorders.2019; 67: 74. CrossRef - Woodhouse–Sakati Syndrome: First report of a Portuguese case
Pedro Louro, João Durães, Diana Oliveira, Sandra Paiva, Lina Ramos, Maria Carmo Macário
American Journal of Medical Genetics Part A.2019; 179(11): 2237. CrossRef - Patterns of neurological manifestations in Woodhouse-Sakati Syndrome
Saeed Bohlega, Ali H. Abusrair, Fahad S. Al-Ajlan, Norah Alharbi, Abdulaziz Al-Semari, Balsam Bohlega, Dalya Abualsaud, Fowzan Alkuraya
Parkinsonism & Related Disorders.2019; 69: 99. CrossRef - Clinical case of a rare neurodegenerative disease with iron accumulation in the brain, type 4, in a 15-year-old child
I. F. Fedoseeva, T. V. Poponnikova, G. Yu. Galieva, S. V. Moschnegootz
Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics).2019; 64(5): 109. CrossRef - Levodopa-induced dyskinesias in mitochondrial membrane protein–associated neurodegeneration
Daniel Savitt, Joseph Jankovic
Neurology: Clinical Practice.2019; 9(1): e7. CrossRef - On the complexity of clinical and molecular bases of neurodegeneration with brain iron accumulation
C. Tello, A. Darling, V. Lupo, B. Pérez‐Dueñas, C. Espinós
Clinical Genetics.2018; 93(4): 731. CrossRef - Les mouvements anormaux : mise au point
M. Béreau, C. Tranchant
La Revue de Médecine Interne.2018; 39(8): 641. CrossRef - Ferrosenescence: The iron age of neurodegeneration?
Adonis Sfera, Kelsey Bullock, Amy Price, Luzmin Inderias, Carolina Osorio
Mechanisms of Ageing and Development.2018; 174: 63. CrossRef - Chemodosimeters and chemoreactands for sensing ferric ions
Karl J. Wallace, Ashley D. G. Johnson, W. Scott Jones, Erendra Manandhar
Supramolecular Chemistry.2018; 30(5-6): 353. CrossRef - Beta‐propeller protein‐associated neurodegeneration: a case report and review of the literature
Kjersti Eline Stige, Ivar Otto Gjerde, Gunnar Houge, Per Morten Knappskog, Charalampos Tzoulis
Clinical Case Reports.2018; 6(2): 353. CrossRef - Looking Deep into the Eye-of-the-Tiger in Pantothenate Kinase–Associated Neurodegeneration
J.-H. Lee, A. Gregory, P. Hogarth, C. Rogers, S.J. Hayflick
American Journal of Neuroradiology.2018; 39(3): 583. CrossRef - Novel PLA2G6 mutations and clinical heterogeneity in Chinese cases with phospholipase A2-associated neurodegeneration
Yi-Jun Chen, Yu-Chao Chen, Hai-Lin Dong, Li-Xi Li, Wang Ni, Hong-Fu Li, Zhi-Ying Wu
Parkinsonism & Related Disorders.2018;[Epub] CrossRef - Expanding the phenotype of SLC25A42‐associated mitochondrial encephalomyopathy
M. Almannai, A. Alasmari, A. Alqasmi, E. Faqeih, F. Al Mutairi, M. Alotaibi, M.M. Samman, W. Eyaid, Y.I. Aljadhai, H.E. Shamseldin, W. Craigen, F.S. Alkuraya
Clinical Genetics.2018; 93(5): 1097. CrossRef - Basal ganglia calcification and novel compound heterozygous mutations in the PANK2 gene in a Chinese boy with classic Pantothenate kinase-associated neurodegeneration
Xulai Shi, Feixia Zheng, Xiuyun Ye, Xiucui Li, Qianlei Zhao, Zhongdong Lin, Ying Hu, Jiwen Wang
Medicine.2018; 97(15): e0316. CrossRef - Botulinum toxin injection to improve functional independence and to alleviate parenting stress in a child with advanced pantothenate kinase-associated neurodegeneration
Cho-I Lin, Kuan-Lin Chen, Ta-Shen Kuan, Sheng-Han Lin, Wei-Pin Lin, Yu-Ching Lin
Medicine.2018; 97(20): e10709. CrossRef - Expanding the Spectrum of Dopa-Responsive Dystonia (DRD) and Proposal for New Definition: DRD, DRD-plus, and DRD Look-alike
Woong-Woo Lee, Beomseok Jeon, Ryul Kim
Journal of Korean Medical Science.2018;[Epub] CrossRef - Oxidative stress and neurodegeneration: the involvement of iron
Alessia Carocci, Alessia Catalano, Maria Stefania Sinicropi, Giuseppe Genchi
BioMetals.2018; 31(5): 715. CrossRef - Non-cell-autonomous actions of α-synuclein: Implications in glial synucleinopathies
Somin Lim, Han-Joon Kim, Dong-Kyu Kim, Seung-Jae Lee
Progress in Neurobiology.2018; 169: 158. CrossRef - Longitudinal study of multiple sclerosis lesions using ultra-high field (7T) multiparametric MR imaging
Sanjeev Chawla, Ilya Kister, Tim Sinnecker, Jens Wuerfel, Jean-Christophe Brisset, Friedemann Paul, Yulin Ge, Quan Jiang
PLOS ONE.2018; 13(9): e0202918. CrossRef - Brain MR Imaging Findings in Woodhouse-Sakati Syndrome
A.H. Abusrair, S. Bohlega, A. Al-Semari, F.S. Al-Ajlan, K. Al-Ahmadi, B. Mohamed, A. AlDakheel
American Journal of Neuroradiology.2018; 39(12): 2256. CrossRef - The Involvement of Iron in Traumatic Brain Injury and Neurodegenerative Disease
Maria Daglas, Paul A. Adlard
Frontiers in Neuroscience.2018;[Epub] CrossRef - Imaging of dentate nucleus pathologies; a pictorial essay
Kajari Bhattacharya, Hima Pendharkar, Arun K Gupta
Indian Journal of Radiology and Imaging.2018; 28(02): 152. CrossRef - Identification of Novel Compound Mutations in PLA2G6-Associated Neurodegeneration Patient with Characteristic MRI Imaging
Sen Guo, Liu Yang, Huijie Liu, Wei Chen, Jinchen Li, Ping Yu, Zhong Sheng Sun, Xiang Chen, Jie Du, Tao Cai
Molecular Neurobiology.2017; 54(6): 4636. CrossRef - Serum Ferritin Levels Are Lower in Children With Tic Disorders Compared with Children Without Tics: A Cross-Sectional Study
Matan Avrahami, Ran Barzilay, Miki HarGil, Abraham Weizman, Nathan Watemberg
Journal of Child and Adolescent Psychopharmacology.2017; 27(2): 192. CrossRef - Autres syndromes parkinsoniens
Christine Tranchant
La Presse Médicale.2017; 46(2): 210. CrossRef - Ferrous Iron Up-regulation in Fibroblasts of Patients with Beta Propeller Protein-Associated Neurodegeneration (BPAN)
Rosaria Ingrassia, Maurizio Memo, Barbara Garavaglia
Frontiers in Genetics.2017;[Epub] CrossRef - Radiological Findings of Two Sisters with Aceruloplasminemia Presenting with Chorea
H. K. Kim, C. S. Ki, Y. J. Kim, M. S. Lee
Clinical Neuroradiology.2017; 27(3): 385. CrossRef - Mitochondrial membrane protein-associated neurodegeneration
Angela Deutschländer, Takuya Konno, Owen A. Ross
Parkinsonism & Related Disorders.2017; 39: 1. CrossRef - Intragenic deletion of the WDR45 gene in a male with encephalopathy, severe psychomotor disability, and epilepsy
Sylvia Redon, Caroline Benech, Sacha Schutz, Aurore Despres, Paul Gueguen, Pauline Le Berre, Cédric Le Marechal, Sylviane Peudenier, Philippe Meriot, Philippe Parent, Claude Ferec
American Journal of Medical Genetics Part A.2017; 173(5): 1444. CrossRef - Clinical and Imaging Presentation of a Patient with Beta-Propeller Protein-Associated Neurodegeneration, a Rare and Sporadic form of Neurodegeneration with Brain Iron Accumulation (NBIA)
Elke Hattingen, Nikolaus Handke, Kirsten Cremer, Sabine Hoffjan, Guido Matthias Kukuk
Clinical Neuroradiology.2017; 27(4): 481. CrossRef - Dentate Update: Imaging Features of Entities That Affect the Dentate Nucleus
K.M. Bond, W. Brinjikji, L.J. Eckel, D.F. Kallmes, R.J. McDonald, C.M. Carr
American Journal of Neuroradiology.2017; 38(8): 1467. CrossRef - Available treatment options for dystonia
Isabel Alfradique-Dunham, Joseph Jankovic
Expert Opinion on Orphan Drugs.2017; 5(9): 707. CrossRef - Clinical rating scale for pantothenate kinase‐associated neurodegeneration: A pilot study
Alejandra Darling, Cristina Tello, María Josep Martí, Cristina Garrido, Sergio Aguilera‐Albesa, Miguel Tomás Vila, Itziar Gastón, Marcos Madruga, Luis González Gutiérrez, Julio Ramos Lizana, Montserrat Pujol, Tania Gavilán Iglesias, Kylee Tustin, Jean Pie
Movement Disorders.2017; 32(11): 1620. CrossRef - iPSC-derived neuronal models of PANK2-associated neurodegeneration reveal mitochondrial dysfunction contributing to early disease
Charles Arber, Plamena R. Angelova, Sarah Wiethoff, Yugo Tsuchiya, Francesca Mazzacuva, Elisavet Preza, Kailash P. Bhatia, Kevin Mills, Ivan Gout, Andrey Y. Abramov, John Hardy, James A. Duce, Henry Houlden, Selina Wray, Fanis Missirlis
PLOS ONE.2017; 12(9): e0184104. CrossRef - Presynaptic Dopaminergic Degeneration in a Patient with Beta-Propeller Protein-Associated Neurodegeneration Documented by Dopamine Transporter Positron Emission Tomography Images: A Case Report
Min Ki Kim, Nan Young Kim, Sangkyoon Hong, Hyeo-Il Ma, Yun Joong Kim
Journal of Movement Disorders.2017; 10(3): 161. CrossRef - Iron in neurodegenerative disorders: being in the wrong place at the wrong time?
Sotirios Apostolakis, Anna-Maria Kypraiou
Reviews in the Neurosciences.2017; 28(8): 893. CrossRef - Lessons from a pair of siblings with BPAN
Yuri A Zarate, Julie R Jones, Melanie A Jones, Francisca Millan, Jane Juusola, Annette Vertino-Bell, G Bradley Schaefer, Michael C Kruer
European Journal of Human Genetics.2016; 24(7): 1080. CrossRef - “Eye of tiger sign” mimic in an adolescent boy with mitochondrial membrane protein associated neurodegeneration (MPAN)
Sangeetha Yoganathan, Sniya Valsa Sudhakar, Maya Thomas, Atanu Kumar Dutta, Sumita Danda
Brain and Development.2016; 38(5): 516. CrossRef - Gene co-expression networks shed light into diseases of brain iron accumulation
Conceição Bettencourt, Paola Forabosco, Sarah Wiethoff, Moones Heidari, Daniel M. Johnstone, Juan A. Botía, Joanna F. Collingwood, John Hardy, Elizabeth A. Milward, Mina Ryten, Henry Houlden
Neurobiology of Disease.2016; 87: 59. CrossRef - Brain iron accumulation affects myelin-related molecular systems implicated in a rare neurogenetic disease family with neuropsychiatric features
M Heidari, D M Johnstone, B Bassett, R M Graham, A C G Chua, M J House, J F Collingwood, C Bettencourt, H Houlden, M Ryten, J K Olynyk, D Trinder, E A Milward
Molecular Psychiatry.2016; 21(11): 1599. CrossRef - WDR45 mutations in Rett (-like) syndrome and developmental delay: Case report and an appraisal of the literature
Sabine Hoffjan, Aysegül Ibisler, Anne Tschentscher, Gabriele Dekomien, Carla Bidinost, Alberto L. Rosa
Molecular and Cellular Probes.2016;[Epub] CrossRef - Missions of <italic>Journal of Movement Disorders</italic>
Yun Joong Kim
Journal of Movement Disorders.2016; 9(1): 1. CrossRef - Clinical Heterogeneity of Atypical Pantothenate Kinase-Associated Neurodegeneration in Koreans
Jae-Hyeok Lee, Jongkyu Park, Ho-Sung Ryu, Hyeyoung Park, Young Eun Kim, Jin Yong Hong, Sang Ook Nam, Young-Hee Sung, Seung-Hwan Lee, Jee-Young Lee, Myung Jun Lee, Tae-Hyoung Kim, Chul Hyoung Lyoo, Sun Ju Chung, Seong Beom Koh, Phil Hyu Lee, Jin Whan Cho,
Journal of Movement Disorders.2016; 9(1): 20. CrossRef - «Et høist mærkeligt Sygdomstilfælde hos flere Sødskende» – en norsk førstegangsbeskrivelse fra 1830?
Magne Nylenna, Noralv Breivik, Arvid Heiberg, Øivind Larsen
Tidsskrift for Den norske legeforening.2016; 136(5): 437. CrossRef - Woodhouse-Sakati Syndrome: Report of the First Tunisian Family with the C2orf37 Gene Mutation
Olfa Hdiji, Emna Turki, Nouha Bouzidi, Imen Bouchhima, Mariem Damak, Saeed Bohlega, Chokri Mhiri
Journal of Movement Disorders.2016; 9(2): 120. CrossRef - Encefalopatie metaboliche e tossiche non farmacologiche
P. Codron, C. Verny
EMC - Neurologia.2016; 16(3): 1. CrossRef - Iron and Non-Iron-Related Characteristics of Multiple Sclerosis and Neuromyelitis Optica Lesions at 7T MRI
S. Chawla, I. Kister, J. Wuerfel, J.- C. Brisset, S. Liu, T. Sinnecker, P. Dusek, E. M. Haacke, F. Paul, Y. Ge
American Journal of Neuroradiology.2016; 37(7): 1223. CrossRef - Freezing of gait in Parkinson's disease: from pathophysiology to emerging therapies
Alberto Cucca, Milton C Biagioni, Jori E Fleisher, Shashank Agarwal, Andre Son, Pawan Kumar, Miroslaw Brys, Alessandro Di Rocco
Neurodegenerative Disease Management.2016; 6(5): 431. CrossRef - Neurodegeneration with brain iron accumulation
João Carlos Papaterra Limongi
Arquivos de Neuro-Psiquiatria.2016; 74(7): 517. CrossRef - Neurodegeneration with brain iron accumulation: A case report
Daniel Nassif, João Santos Pereira, Mariana Spitz, Cláudia Capitão, Alessandra Faria
Dementia & Neuropsychologia.2016; 10(2): 160. CrossRef - What’s in a name? Problems, facts and controversies regarding neurological eponyms
Hélio A. G. Teive, Plínio M. G. Lima, Francisco M. B. Germiniani, Renato P. Munhoz
Arquivos de Neuro-Psiquiatria.2016; 74(5): 423. CrossRef - A diagnostic approach for neurodegeneration with brain iron accumulation: clinical features, genetics and brain imaging
Rubens Paulo Araújo Salomão, José Luiz Pedroso, Maria Thereza Drumond Gama, Lívia Almeida Dutra, Ricardo Horta Maciel, Clécio Godeiro-Junior, Hsin Fen Chien, Hélio A. G. Teive, Francisco Cardoso, Orlando G. P. Barsottini
Arquivos de Neuro-Psiquiatria.2016; 74(7): 587. CrossRef - Novel homozygous PANK2 mutation identified in a consanguineous Chinese pedigree with pantothenate kinase-associated neurodegeneration
Yan-Fang Li, Hong-Fu Li, Yan-Bin Zhang, Ji-Min Wu
Biomedical Reports.2016; 5(2): 217. CrossRef - NBIA - neurodegeneration with brain iron accumulation
Lenka Hvizdošová, Michaela Kaiserová, Petr Kaňovský, Marek Baláž
Neurologie pro praxi.2016; 17(5): 328. CrossRef - Orally Bioavailable Metal Chelators and Radical Scavengers: Multifunctional Antioxidants for the Coadjutant Treatment of Neurodegenerative Diseases
Hiroyoshi Kawada, Peter F. Kador
Journal of Medicinal Chemistry.2015; 58(22): 8796. CrossRef - Voxel-based analysis in neuroferritinopathy expands the phenotype and determines radiological correlates of disease severity
M. J. Keogh, B. S. Aribisala, J. He, E. Tulip, D. Butteriss, C. Morris, G. Gorman, R. Horvath, P. F. Chinnery, Andrew M. Blamire
Journal of Neurology.2015; 262(10): 2232. CrossRef - A field guide to current advances in paediatric movement disorders
Laura Silveira-Moriyama, Jean-Pierre Lin
Current Opinion in Neurology.2015; 28(4): 437. CrossRef - En mann i 50-årene med høyt ferritinnivå og økende kognitiv svikt
Marte-Helene Bjørk, Ivar Otto Gjerde, Charalampos Tzoulis, Rune Johan Ulvik, Laurence Albert Bindoff
Tidsskrift for Den norske legeforening.2015; 135(15): 1369. CrossRef - Iron, Aging, and Neurodegeneration
Dafina Angelova, David Brown
Metals.2015; 5(4): 2070. CrossRef
- Missing heritability of Wilson disease: a search for the uncharacterized mutations
- Many Faces of Parkinson’s Disease: Non-Motor Symptoms of Parkinson’s Disease
- Hye Mi Lee, Seong-Beom Koh
- J Mov Disord. 2015;8(2):92-97. Published online May 31, 2015
- DOI: https://doi.org/10.14802/jmd.15003
- 21,398 View
- 532 Download
- 90 Citations
-
Abstract
PDF
- Parkinson’s disease (PD) is a multi-systemic disorder that is characterized by a combination of motor and non-motor symptoms (NMS). The dopaminergic neurodegeneration of PD is involved in the genesis of NMS, but other conditions and side effects of levodopa are also associated with NMS. NMS can develop at all stage of PD and rapid eyeball movement sleep behavior disorder (RBD), constipation, depression, and olfactory dysfunction are considered prodromal signs of PD. Many NMS related with motor deficits and cognitive dysfunction. Some NMS including olfactory dysfunction, RBD and abnormal stereopsis are associated with presence of other NMS of PD. In addition, several NMS can be helpful to differentiate between idiopathic PD and other parkinsonian disorders. Early recognition and management of NMS in PD patients is important for preserving quality of life.
-
Citations
Citations to this article as recorded by- Robotic technology for Parkinson's disease: Needs, attitudes and concerns of individuals with Parkinson's disease and their family members. A focus group study
Azriel Kaplan, Shirel Barkan-Slater, Yair Zlotnik, Shelly Levy-Tzedek
International Journal of Human-Computer Studies.2024; 181: 103148. CrossRef - Neuroprotective effect of anethole against rotenone induced non-motor deficits and oxidative stress in rat model of Parkinson’s disease
Sadegh Moradi Vastegani, Seyed Esmaeil Khoshnam, Esrafil Mansouri, Somayeh Hajipour, Samireh Ghafouri, Nima Bakhtiari, Alireza Sarkaki, Yaghoob Farbood
Behavioural Brain Research.2023; 437: 114100. CrossRef - The effects of synbiotic supplementation on oxidative stress markers, mental status, and quality of life in patients with Parkinson’s disease: A double-blind, placebo-controlled, randomized controlled trial
Sanaz Mehrabani, Fariborz Khorvash, Zahra Heidari, Maryam Tajabadi-Ebrahimi, Reza Amani
Journal of Functional Foods.2023; 100: 105397. CrossRef - Role of Ceramides and Sphingolipids in Parkinson's Disease
Melissa Vos, Christine Klein, Andrew A Hicks
Journal of Molecular Biology.2023; 435(12): 168000. CrossRef - Efficacy of herbal medicine treatment based on syndrome differentiation for Parkinson’s disease: A systematic review and meta-analysis of randomized placebo-controlled clinical trials
Purumea Jun, HuiYan Zhao, In Chul Jung, Ojin Kwon, Chang-Hyun Han, Jiyoon Won, Jung-Hee Jang
Frontiers in Pharmacology.2023;[Epub] CrossRef - A meta-analysis of exercise intervention and the effect on Parkinson’s Disease symptoms
Syed Omar Ahmad, Jason Longhurst, Dana Stiles, Lana Downard, Stephanie Martin
Neuroscience Letters.2023; 801: 137162. CrossRef - Controlling the Impact of Helicobacter pylori-Related Hyperhomocysteinemia on Neurodegeneration
Jannis Kountouras, Michael Doulberis, Apostolis Papaefthymiou, Stergios A. Polyzos, Christos Zavos, Evangelos Kazakos, Stergios Arapoglou, Foteini Kyrailidi, Maria C. Mouratidou, Marina Boziki, Elisabeth Vardaka
Medicina.2023; 59(3): 504. CrossRef - Case management interventions in chronic disease reduce anxiety and depressive symptoms: A systematic review and meta-analysis
Angelika D. Geerlings, Jules M. Janssen Daalen, Jan H. L. Ypinga, Bastiaan R. Bloem, Marjan J. Meinders, Marten Munneke, Sirwan K. L. Darweesh, Vincenzo De Luca
PLOS ONE.2023; 18(4): e0282590. CrossRef - Is there any correlation between alpha-synuclein levels in tears and retinal layer thickness in Parkinson's disease?
Azyadeh Camacho-Ordonez, Amin Cervantes-Arriaga, Mayela Rodríguez-Violante, Ana Jimena Hernandez-Medrano, Selma Alin Somilleda-Ventura, Hector J. Pérez-Cano, Ángel Nava-Castañeda, Oscar Guerrero-Berger
European Journal of Ophthalmology.2023; : 112067212311737. CrossRef - Bio-synthesized selenium nanoparticles ameliorate Brain oxidative stress in Parkinson disease rat models
Sanaz Salaramoli, Hamed Amiri, Hamid Reza Joshaghani, Mahmoud Hosseini, Seyed Isaac Hashemy
Metabolic Brain Disease.2023; 38(6): 2055. CrossRef - Therapeutic Approaches to Non-Motor Symptoms of Parkinson's Disease:
A Current Update on Preclinical Evidence
Poornima D.E. Weerasinghe-Mudiyanselage, Sohi Kang, Joong-Sun Kim, Changjong Moon
Current Neuropharmacology.2023; 21(3): 560. CrossRef - Psychosis in Parkinson’s Disease and Current Management Trends- an Updated Review of Literature
Dutta Rajib
Journal of Neuroscience and Neurological Disorders.2023; 7(2): 027. CrossRef - The Molecular Mechanisms of the Relationship between Insulin Resistance and Parkinson’s Disease Pathogenesis
Viviana A. Ruiz-Pozo, Rafael Tamayo-Trujillo, Santiago Cadena-Ullauri, Evelyn Frias-Toral, Patricia Guevara-Ramírez, Elius Paz-Cruz, Sebastián Chapela, Martha Montalván, Tania Morales-López, Daniel Simancas-Racines, Ana Karina Zambrano
Nutrients.2023; 15(16): 3585. CrossRef - Enhancing Parkinson's disease severity assessment through voice-based wavelet scattering, optimized model selection, and weighted majority voting
Farhad Abedinzadeh Torghabeh, Seyyed Abed Hosseini, Elham Ahmadi Moghadam
Medicine in Novel Technology and Devices.2023; 20: 100266. CrossRef - A look back at the prodromal findings in Parkinson’s disease
Seyed-Amirabbas Ahadiat, Zeinab Hosseinian
Bulletin of the National Research Centre.2023;[Epub] CrossRef - Parkinson’s Disease Non-Motor Subtypes Classification in a Group of Slovenian Patients: Actuarial vs. Data-Driven Approach
Timotej Petrijan, Jan Zmazek, Marija Menih
Journal of Clinical Medicine.2023; 12(23): 7434. CrossRef - REM sleep behavioral disorder may be an independent risk factor for orthostatic hypotension in Parkinson’s disease
Kangfu Yin, Chuanbin Zhou, Yongyun Zhu, Weifang Yin, Lei Yin, Bin Liu, Hui Ren, Zhong Xu, Xinglong Yang
Aging Clinical and Experimental Research.2022; 34(1): 159. CrossRef - Gender Differences and Impact of Autonomic Disturbance on Fatigue and Quality of Life in Parkinson's Disease
NahushR Bansal, BirinderS Paul, Gunchan Paul, Gagandeep Singh
Neurology India.2022;[Epub] CrossRef - Exploring Unmet Information Needs of People with Parkinson’s Disease and Their Families: Focusing on Information Sharing in an Online Patient Community
Hyeon Sik Chu, Hye Young Jang
International Journal of Environmental Research and Public Health.2022; 19(5): 2521. CrossRef - Gut microbiota and inflammation in Parkinson’s disease: Pathogenetic and therapeutic insights
Tong Guo, Li Chen
European Journal of Inflammation.2022; 20: 1721727X2210837. CrossRef - Diffusion Tensor Imaging Reveals Deep Brain Structure Changes in Early Parkinson’s Disease Patients with Various Sleep Disorders
Yanyan Jiang, Hedi An, Qian Xi, Weiting Yang, Hongrong Xie, Yang Li, Dongya Huang
Brain Sciences.2022; 12(4): 463. CrossRef - Clinical Aspects of the Differential Diagnosis of Parkinson’s Disease and Parkinsonism
Hae-Won Shin, Sang-Wook Hong, Young Chul Youn
Journal of Clinical Neurology.2022; 18(3): 259. CrossRef - Effect of mobile health intervention for self-management on self-efficacy, motor and non-motor symptoms, self-management, and quality of life in people with Parkinson's disease: Randomized controlled trial
Yusun Park, Sung Reul Kim, Hui Young So, Sungyang Jo, Seung Hyun Lee, Yun su Hwang, Mi Sun Kim, Sun Ju Chung
Geriatric Nursing.2022; 46: 90. CrossRef - Ghrelin mediated regulation of neurosynaptic transmitters in depressive disorders
Milind V. Masule, Sumit Rathod, Yogeeta Agrawal, Chandragouda R. Patil, Kartik T. Nakhate, Shreesh Ojha, Sameer N. Goyal, Umesh B. Mahajan
Current Research in Pharmacology and Drug Discovery.2022; 3: 100113. CrossRef - Psychosis in Parkinson’s Disease: A Lesson from Genetics
Efthalia Angelopoulou, Anastasia Bougea, Sokratis G. Papageorgiou, Chiara Villa
Genes.2022; 13(6): 1099. CrossRef - Non-motor manifestation of Parkinson's disease: a cross-sectional study in a teaching hospital in Jordan
Said Salah Dahbour, Mohammad J. Al Murr, Liyan H. Oweis, Nada T. Al Antary, Maram Mohsen, Safa Al Fegi
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery.2022;[Epub] CrossRef - Neuroprotective effects of probiotics bacteria on animal model of Parkinson’s disease induced by 6-hydroxydopamine: A behavioral, biochemical, and histological study
Esmail Alipour Nosrani, Omid Reza Tamtaji, Zahra Alibolandi, Parichehr Sarkar, Mohsen Ghazanfari, Abolfazl Azami Tameh, Mohsen Taghizadeh, Zarrin Banikazemi, Razie Hadavi, Mojtaba Naderi Taheri
Journal of Immunoassay and Immunochemistry.2021; 42(2): 106. CrossRef - SURINPARK: Safinamide for Urinary Symptoms in Parkinson’s Disease
Ana Gómez-López, Arantxa Sánchez-Sánchez, Elena Natera-Villalba, Victoria Ros-Castelló, Álvaro Beltrán-Corbellini, Samira Fanjul-Arbós, Isabel Pareés Moreno, José Luis López-Sendon Moreno, Juan Carlos Martínez Castrillo, Araceli Alonso-Canovas
Brain Sciences.2021; 11(1): 57. CrossRef - People with Parkinson’s Disease: What Symptoms Do They Most Want to Improve and How Does This Change with Disease Duration?
Rebecca J. Port, Martin Rumsby, Graham Brown, Ian F. Harrison, Anneesa Amjad, Claire J. Bale
Journal of Parkinson's Disease.2021; 11(2): 715. CrossRef - Rho‐kinase inhibition by fasudil modulates pre‐synaptic vesicle dynamics
Kim Ann Saal, Carmina Warth Pérez Arias, Anna‐Elisa Roser, Jan Christoph Koch, Mathias Bähr, Silvio O. Rizzoli, Paul Lingor
Journal of Neurochemistry.2021; 157(4): 1052. CrossRef - A Comprehensive Phenotype of Non-motor Impairments and Distribution of Alpha-Synuclein Deposition in Parkinsonism-Induced Mice by a Combination Injection of MPTP and Probenecid
Na-Ra Han, Yu-Kang Kim, Sora Ahn, Tae-Yeon Hwang, Hyejung Lee, Hi-Joon Park
Frontiers in Aging Neuroscience.2021;[Epub] CrossRef - Association of Parkinson’s Disease With Microbes and Microbiological Therapy
Zhao-Ji Chen, Cheng-Yu Liang, Li-Qing Yang, Si-Min Ren, Yan-Min Xia, Lei Cui, Xiao-Fang Li, Bu-Lang Gao
Frontiers in Cellular and Infection Microbiology.2021;[Epub] CrossRef - Plasma Lipopolysaccharide-Binding Protein Reflects Risk and Progression of Parkinson’s Disease
Szu-Ju Chen, Yu-Chiao Chi, Chang-Han Ho, Wei-Shiung Yang, Chin-Hsien Lin
Journal of Parkinson's Disease.2021; 11(3): 1129. CrossRef - The Importance of Drosophila melanogaster Research to UnCover Cellular Pathways Underlying Parkinson’s Disease
Melissa Vos, Christine Klein
Cells.2021; 10(3): 579. CrossRef - Docosahexaenoic and Arachidonic Acids as Neuroprotective Nutrients throughout the Life Cycle
Verónica Sambra, Francisca Echeverria, Alfonso Valenzuela, Raphaël Chouinard-Watkins, Rodrigo Valenzuela
Nutrients.2021; 13(3): 986. CrossRef - What substance P might tell us about the prognosis and mechanism of Parkinson's disease?
Paola Tirassa, Tommaso Schirinzi, Marcello Raspa, Massimo Ralli, Antonio Greco, Antonella Polimeni, Roberta Possenti, Nicola Biagio Mercuri, Cinzia Severini
Neuroscience & Biobehavioral Reviews.2021; 131: 899. CrossRef - Baicalein alleviates depression-like behavior in rotenone- induced Parkinson's disease model in mice through activating the BDNF/TrkB/CREB pathway
Xiaoyue Zhao, Dewen Kong, Qimeng Zhou, Guangyi Wei, Junke Song, Yu Liang, Guanhua Du
Biomedicine & Pharmacotherapy.2021; 140: 111556. CrossRef - Apathy and actions- another consideration when theorizing about embodied nature of language in Parkinson's disease
Logan Wolff, Jared F. Benge, Samia Ortiz-Hernandez, Samantha Beevers, Alexandra Armitage, Jungjun Park, Daniel L. Drane
Journal of Communication Disorders.2021; 93: 106144. CrossRef - Association analysis and polygenic risk score evaluation of 38 GWAS-identified Loci in a Chinese population with Parkinson’s disease
Ran Zheng, Song Qiao, Ying Chen, Chongyao Jin, Yi Fang, Zhihao Lin, Naijia Xue, Yiqun Yan, Luyan Gu, Ting Gao, Jun Tian, Yaping Yan, Xinzhen Yin, Jiali Pu, Baorong Zhang
Neuroscience Letters.2021; 762: 136150. CrossRef - Non-motor impairments affect walking kinematics in Parkinson disease patients: A cross-sectional study
Sara Liguori, Antimo Moretti, Angela Palomba, Marco Paoletta, Francesca Gimigliano, Rosa De Micco, Mattia Siciliano, Alessandro Tessitore, Giovanni Iolascon
NeuroRehabilitation.2021; 49(3): 481. CrossRef - The role of gut dysbiosis in Parkinson’s disease: mechanistic insights and therapeutic options
Qing Wang, Yuqi Luo, K Ray Chaudhuri, Richard Reynolds, Eng-King Tan, Sven Pettersson
Brain.2021; 144(9): 2571. CrossRef - Clinical features contributing to the sit-to-stand transfer in people with Parkinson’s disease: a systematic review
Charmaine Pearl Da Cunha, Pratiksha Tilak Rao, Suruliraj Karthikbabu
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery.2021;[Epub] CrossRef - Integration of Aluminium Interdigitated Electrodes with Zinc Oxide as Nanocomposite for Selectively Detect Alpha-Synuclein for Parkinson’s Disease Diagnosis
Hussaini Adam, Subash C. B Gopinath, Uda Hashim
Journal of Physics: Conference Series.2021; 2129(1): 012094. CrossRef - Effects of depression and exercise on health-related quality of life in patients with Parkinson's disease
George W Koutsouras, Kimberly Levine, Nathalie Duroseau, Christina Ciraco, Vivian Chan, Kathleen Pergament, Thomas Chan, Jayme D Mancini, Adena N Leder, Bhuma Krishnamachari
Chronic Illness.2020; 16(3): 190. CrossRef - Glial Cell Line–Derived Neurotrophic Factor Receptor Rearranged During Transfection Agonist Supports Dopamine Neurons In Vitro and Enhances Dopamine Release In Vivo
Arun Kumar Mahato, Jaakko Kopra, Juho‐Matti Renko, Tanel Visnapuu, Ilari Korhonen, Nita Pulkkinen, Maxim M. Bespalov, Andrii Domanskyi, Eric Ronken, T. Petteri Piepponen, Merja H. Voutilainen, Raimo K. Tuominen, Mati Karelson, Yulia A. Sidorova, Mart Saar
Movement Disorders.2020; 35(2): 245. CrossRef - Early transcranial direct current stimulation treatment exerts neuroprotective effects on 6-OHDA-induced Parkinsonism in rats
Xiao-Jun Feng, Yu-Ting Huang, Ying-Zu Huang, Chi-Wei Kuo, Chih-Wei Peng, Alexander Rotenberg, Chi-Hung Juan, Yu-Cheng Pei, Yuan-Hao Chen, Kai-Yun Chen, Yung-Hsiao Chiang, Hui-Hua Liu, Jian-Xian Wu, Tsung-Hsun Hsieh
Brain Stimulation.2020; 13(3): 655. CrossRef - Dizziness in patients with early stages of Parkinson's disease: Prevalence, clinical characteristics and implications
Kyum‐Yil Kwon, Suyeon Park, Mina Lee, Hyunjin Ju, Kayeong Im, Byung‐Euk Joo, Kyung Bok Lee, Hakjae Roh, Moo‐Young Ahn
Geriatrics & Gerontology International.2020; 20(5): 443. CrossRef - The Dysfunctional Autonomic Function and “Dysfunctional” Fatigue in Drug Naïve Parkinson’s Disease
Jong Hyeon Ahn, Minkyeong Kim, Jun Kyu Mun, Yoonsu Cho, Ji Sun Kim, Jinyoung Youn, Joong-Seok Kim, Jin Whan Cho
Journal of Parkinson's Disease.2020; 10(2): 605. CrossRef - Assessments of plasma acyl-ghrelin levels in Parkinson’s disease patients treated with deep brain stimulation
Wojciech Pietraszko, Agata Furgala, Agnieszka Gorecka-Mazur, Borys Kwinta, Jolanta Kaszuba-Zwoinska, Jaroslaw Polak, Urszula Fiszer, Krzysztof Gil, Anna Krygowska-Wajs
Peptides.2020; 128: 170299. CrossRef - Common and unique connectivity at the interface of motor, neuropsychiatric, and cognitive symptoms in Parkinson's disease: A commonality analysis
Stefan Lang, Zahinoor Ismail, Mekale Kibreab, Iris Kathol, Justyna Sarna, Oury Monchi
Human Brain Mapping.2020; 41(13): 3749. CrossRef - Systems Biology Approaches to Understand the Host–Microbiome Interactions in Neurodegenerative Diseases
Dorines Rosario, Jan Boren, Mathias Uhlen, Gordon Proctor, Dag Aarsland, Adil Mardinoglu, Saeed Shoaie
Frontiers in Neuroscience.2020;[Epub] CrossRef - Rpt2 proteasome subunit reduction causes Parkinson's disease like symptoms in Drosophila
Iván Fernández-Cruz, Iván Sánchez-Díaz, Verónica Narváez-Padilla, Enrique Reynaud
IBRO Reports.2020; 9: 65. CrossRef - Boxing to Improve Sleep Quality and Daytime Sleepiness in Individuals With Parkinson Disease
Macy Urrutia, Cynthia Ivy, Patricia S. Pohl, Linda Denney
Topics in Geriatric Rehabilitation.2020; 36(3): 170. CrossRef - Effects of the probiotic formulation SLAB51 in in vitro and in vivo Parkinson’s disease models
Vanessa Castelli, Michele d’Angelo, Francesca Lombardi, Margherita Alfonsetti, Andrea Antonosante, Mariano Catanesi, Elisabetta Benedetti, Paola Palumbo, Maria Grazia Cifone, Antonio Giordano, Giovambattista Desideri, Annamaria Cimini
Aging.2020; 12(5): 4641. CrossRef - Depressive symptoms are associated with worse cognitive prognosis in patients with newly diagnosed idiopathic Parkinson disease
Jeong Hoon Park, Seung Hwan Lee, Yeshin Kim, Sang‐Won Park, Gi Hwan Byeon, Jae‐Won Jang
Psychogeriatrics.2020; 20(6): 880. CrossRef - Lack of association between dopamine transporter loss and non-motor symptoms in patients with Parkinson’s disease: a detailed PET analysis of 12 striatal subregions
Soo Bin Park, Kyum-Yil Kwon, Jeong-Yoon Lee, Kayeong Im, Jun-Sang Sunwoo, Kyung Bok Lee, Hakjae Roh, Moo-Young Ahn, Suyeon Park, Soo-Jong Kim, Jungsu S. Oh, Jae Seung Kim
Neurological Sciences.2019; 40(2): 311. CrossRef - Cognitive Problems in Parkinson Disease: Perspectives and Priorities of Patients and Care Partners
Katrina L. Raein, Samia Ortiz-Hernández, Jared F. Benge
Cognitive and Behavioral Neurology.2019; 32(1): 16. CrossRef - Probiotics mixture increases butyrate, and subsequently rescues the nigral dopaminergic neurons from MPTP and rotenone-induced neurotoxicity
Sunil Srivastav, Sabita Neupane, Sunil Bhurtel, Nikita Katila, Sailesh Maharjan, Hyukjae Choi, Jin Tae Hong, Dong-Young Choi
The Journal of Nutritional Biochemistry.2019; 69: 73. CrossRef - Asymptomatic Hearing Impairment Frequently Occurs in Early-Onset Parkinson’s Disease
Kuldeep Shetty, Syam Krishnan, Jissa Vinoda Thulaseedharan, Manju Mohan, Asha Kishore
Journal of Movement Disorders.2019; 12(2): 84. CrossRef - Detecting Non-cognitive Features of Prodromal Neurodegenerative Diseases
Alon Seifan, Christine A. Ganzer, Krista Ryon, Michael Lin, Rahman Mahmudur, Henriquez Adolfo, Cindy Shih, Alan R. Jacobs, Molly Greenwald, Richard S. Isaacson
Current Aging Science.2019; 11(4): 242. CrossRef - Elevated Serum Homocysteine Levels Have Differential Gender-Specific Associations with Motor and Cognitive States in Parkinson’s Disease
Megan C. Bakeberg, Alexa Jefferson, Maddeson Riley, Michelle Byrnes, Soumya Ghosh, Frank L. Mastaglia, Malcom K. Horne, Sarah McGregor, Rick Stell, Jade Kenna, Sue Walters, Dana Hince, Ryan S. Anderton
Parkinson's Disease.2019; 2019: 1. CrossRef - α-Synuclein in Parkinson’s disease: causal or bystander?
Peter Riederer, Daniela Berg, Nicolas Casadei, Fubo Cheng, Joseph Classen, Christian Dresel, Wolfgang Jost, Rejko Krüger, Thomas Müller, Heinz Reichmann, Olaf Rieß, Alexander Storch, Sabrina Strobel, Thilo van Eimeren, Hans-Ullrich Völker, Jürgen Winkler,
Journal of Neural Transmission.2019; 126(7): 815. CrossRef - Selegiline Recovers Synaptic Plasticity in the Medial Prefrontal Cortex and Improves Corresponding Depression-Like Behavior in a Mouse Model of Parkinson’s Disease
Motoki Okano, Kazue Takahata, Junya Sugimoto, Shizuko Muraoka
Frontiers in Behavioral Neuroscience.2019;[Epub] CrossRef - Inner retinal thinning as a biomarker for cognitive impairment in de novo Parkinson’s disease
Mi Sun Sung, Seong-Min Choi, Jonghwa Kim, Jun Young Ha, Byeong-Chae Kim, Hwan Heo, Sang Woo Park
Scientific Reports.2019;[Epub] CrossRef - Probiotics for Parkinson’s Disease
Gazerani
International Journal of Molecular Sciences.2019; 20(17): 4121. CrossRef - The Role of the Gut Microbiota in the Pathogenesis of Parkinson's Disease
Dongming Yang, Deming Zhao, Syed Zahid Ali Shah, Wei Wu, Mengyu Lai, Xixi Zhang, Jie Li, Zhiling Guan, Huafen Zhao, Wen Li, Hongli Gao, Xiangmei Zhou, Lifeng Yang
Frontiers in Neurology.2019;[Epub] CrossRef - Long-Term Voluntary Physical Exercise Exerts Neuroprotective Effects and Motor Disturbance Alleviation in a Rat Model of Parkinson’s Disease
Wan-Ling Tsai, Hsin-Yung Chen, Ying-Zu Huang, Yuan-Hao Chen, Chi-Wei Kuo, Kai-Yun Chen, Tsung-Hsun Hsieh
Behavioural Neurology.2019; 2019: 1. CrossRef - The effectiveness of istradefylline for the treatment of gait deficits and sleepiness in patients with Parkinson’s disease
Keita Matsuura, Hiroyuki Kajikawa, Ken-ichi Tabei, Masayuki Satoh, Hirotaka Kida, Naoko Nakamura, Hidekazu Tomimoto
Neuroscience Letters.2018; 662: 158. CrossRef - Predictors of Mortality in Nondemented Patients With Parkinson Disease: Motor Symptoms Versus Nonmotor Symptoms
D. Santos-García, E. Suárez-Castro, J. Ernandez, I. Expósito-Ruiz, C. Tuñas-Gesto, M. Aneiros-Díaz, T. de Deus-Fonticoba, M. López-Fernández, D. Núñez-Arias
Journal of Geriatric Psychiatry and Neurology.2018; 31(1): 19. CrossRef - Additive Effects of Levodopa and a Neurorestorative Diet in a Mouse Model of Parkinson’s Disease
Paula Perez-Pardo, Laus M. Broersen, Tessa Kliest, Nick van Wijk, Amos Attali, Johan Garssen, Aletta D. Kraneveld
Frontiers in Aging Neuroscience.2018;[Epub] CrossRef - Ghrelin and Neurodegenerative Disorders—a Review
Limin Shi, Xixun Du, Hong Jiang, Junxia Xie
Molecular Neurobiology.2017; 54(2): 1144. CrossRef - The neurological effects of ghrelin in brain diseases: Beyond metabolic functions
Qian Jiao, Xixun Du, Yong Li, Bing Gong, Limin Shi, Tingting Tang, Hong Jiang
Neuroscience & Biobehavioral Reviews.2017; 73: 98. CrossRef - First-in-human assessment of PRX002, an anti-α-synuclein monoclonal antibody, in healthy volunteers
Dale B. Schenk, Martin Koller, Daniel K. Ness, Sue G. Griffith, Michael Grundman, Wagner Zago, Jay Soto, George Atiee, Susanne Ostrowitzki, Gene G. Kinney
Movement Disorders.2017; 32(2): 211. CrossRef - Normal ‘heart’ in Parkinson's disease: is this a distinct clinical phenotype?
J.‐S. Kim, H.‐E. Park, I.‐S. Park, Y.‐S. Oh, D.‐W. Ryu, I.‐U. Song, Y.‐A. Jung, I. R. Yoo, H.‐S. Choi, P. H. Lee, K.‐S. Lee
European Journal of Neurology.2017; 24(2): 349. CrossRef - α-Synuclein in the colon and premotor markers of Parkinson disease in neurologically normal subjects
Joong-Seok Kim, In-Seok Park, Hyung-Eun Park, Su-Young Kim, Jung A Yun, Chan Kwon Jung, Hye-Young Sung, Jin-Kwon Lee, Won-Kyung Kang
Neurological Sciences.2017; 38(1): 171. CrossRef - Use of monoamine oxidase inhibitors in chronic neurodegeneration
Peter Riederer, Thomas Müller
Expert Opinion on Drug Metabolism & Toxicology.2017; 13(2): 233. CrossRef - Validation of the Korean Version of the Scale for Outcomes in Parkinson’s Disease-Autonomic
Ji-Young Kim, In-Uk Song, Seong-Beom Koh, Tae-Beom Ahn, Sang Jin Kim, Sang-Myung Cheon, Jin Whan Cho, Yun Joong Kim, Hyeo-Il Ma, Mee-Young Park, Jong Sam Baik, Phil Hyu Lee, Sun Ju Chung, Jong-Min Kim, Han-Joon Kim, Young-Hee Sung, Do Young Kwon, Jae-Hyeo
Journal of Movement Disorders.2017; 10(1): 29. CrossRef - Retinal biomarkers provide “insight” into cortical pharmacology and disease
Christine T.O. Nguyen, Flora Hui, Jason Charng, Shajan Velaedan, Anna K. van Koeverden, Jeremiah K.H. Lim, Zheng He, Vickie H.Y. Wong, Algis J. Vingrys, Bang V. Bui, Magnus Ivarsson
Pharmacology & Therapeutics.2017; 175: 151. CrossRef - Promising Effects of Neurorestorative Diets on Motor, Cognitive, and Gastrointestinal Dysfunction after Symptom Development in a Mouse Model of Parkinson's Disease
Paula Perez-Pardo, Esther M. de Jong, Laus M. Broersen, Nick van Wijk, Amos Attali, Johan Garssen, Aletta D. Kraneveld
Frontiers in Aging Neuroscience.2017;[Epub] CrossRef - DaT-SPECT assessment depicts dopamine depletion among asymptomatic G2019S LRRK2 mutation carriers
Moran Artzi, Einat Even-Sapir, Hedva Lerman Shacham, Avner Thaler, Avi Orr Urterger, Susan Bressman, Karen Marder, Talma Hendler, Nir Giladi, Dafna Ben Bashat, Anat Mirelman, Elisa Greggio
PLOS ONE.2017; 12(4): e0175424. CrossRef - The gut-brain axis in Parkinson's disease: Possibilities for food-based therapies
Paula Perez-Pardo, Tessa Kliest, Hemraj B. Dodiya, Laus M. Broersen, Johan Garssen, Ali Keshavarzian, Aletta D. Kraneveld
European Journal of Pharmacology.2017; 817: 86. CrossRef - Who Can Diagnose Parkinson's Disease First? Role of Pre-motor Symptoms
Mayela Rodríguez-Violante, Rosalía Zerón-Martínez, Amin Cervantes-Arriaga, Teresa Corona
Archives of Medical Research.2017; 48(3): 221. CrossRef - Microbes Tickling Your Tummy: the Importance of the Gut-Brain Axis in Parkinson’s Disease
Paula Perez-Pardo, Mitch Hartog, Johan Garssen, Aletta D. Kraneveld
Current Behavioral Neuroscience Reports.2017; 4(4): 361. CrossRef - The Therapeutic Potential of Exercise to Improve Mood, Cognition, and Sleep in Parkinson's Disease
Gretchen O. Reynolds, Michael W. Otto, Terry D. Ellis, Alice Cronin‐Golomb
Movement Disorders.2016; 31(1): 23. CrossRef - Orthostatic hypotension and cardiac sympathetic denervation in Parkinson disease patients with REM sleep behavioral disorder
Joong-Seok Kim, Hyung-Eun Park, Yoon-Sang Oh, Si-Hoon Lee, Jeong-Wook Park, Byung-chul Son, Kwang-Soo Lee
Journal of the Neurological Sciences.2016; 362: 59. CrossRef - Relearning of Writing Skills in Parkinson's Disease After Intensive Amplitude Training
Evelien Nackaerts, Elke Heremans, Griet Vervoort, Bouwien C.M. Smits‐Engelsman, Stephan P. Swinnen, Wim Vandenberghe, Bruno Bergmans, Alice Nieuwboer
Movement Disorders.2016; 31(8): 1209. CrossRef - Cardiovascular Autonomic Dysfunction in Mild and Advanced Parkinson’s Disease
Joong-Seok Kim, Si-Hoon Lee, Yoon-Sang Oh, Jeong-Wook Park, Jae-Young An, Sung-Kyung Park, Si-Ryung Han, Kwang-Soo Lee
Journal of Movement Disorders.2016; 9(2): 97. CrossRef - The KMDS-NATION Study: Korean Movement Disorders Society Multicenter Assessment of Non-Motor Symptoms and Quality of Life in Parkinson's Disease NATION Study Group
Do-Young Kwon, Seong-Beom Koh, Jae Hyeok Lee, Hee Kyung Park, Han-Joon Kim, Hae-Won Shin, Jinyoung Youn, Kun Woo Park, Sun-Ah Choi, Sang Jin Kim, Seong-Min Choi, Ji-Yun Park, Beom S. Jeon, Ji Young Kim, Sun Ju Chung, Chong Sik Lee, Jeong-Ho Park, Tae-Beom
Journal of Clinical Neurology.2016; 12(4): 393. CrossRef - Bent out of shape: α‐Synuclein misfolding and the convergence of pathogenic pathways in Parkinson's disease
Esteban Luna, Kelvin C. Luk
FEBS Letters.2015; 589(24PartA): 3749. CrossRef - Differentiated Cells Derived from Fetal Neural Stem Cells Improve Motor Deficits in a Rat Model of Parkinson's Disease
Wei Wang, Hao Song, Aifang Shen, Chao Chen, Yanming Liu, Yabing Dong, Fabin Han
Translational Neuroscience and Clinics.2015; 1(2): 75. CrossRef
- Robotic technology for Parkinson's disease: Needs, attitudes and concerns of individuals with Parkinson's disease and their family members. A focus group study
Original Article
- Exosome-Based Delivery of miR-124 in a Huntington’s Disease Model
- Soon-Tae Lee, Wooseok Im, Jae-Jun Ban, Mijung Lee, Keun-Hwa Jung, Sang Kun Lee, Kon Chu, Manho Kim
- J Mov Disord. 2017;10(1):45-52. Published online January 18, 2017
- DOI: https://doi.org/10.14802/jmd.16054
- 15,485 View
- 361 Download
- 85 Citations
-
Abstract
PDF
- Objective
Huntington’s disease (HD) is a genetic neurodegenerative disease that is caused by abnormal CAG expansion. Altered microRNA (miRNA) expression also causes abnormal gene regulation in this neurodegenerative disease. The delivery of abnormally downregulated miRNAs might restore normal gene regulation and have a therapeutic effect.
Methods
We developed an exosome-based delivery method to treat this neurodegenerative disease. miR-124, one of the key miRNAs that is repressed in HD, was stably overexpressed in a stable cell line. Exosomes were then harvested from these cells using an optimized protocol. The exosomes (Exo-124) exhibited a high level of miR-124 expression and were taken up by recipient cells.
Results
When Exo-124 was injected into the striatum of R6/2 transgenic HD mice, expression of the target gene, RE1-Silencing Transcription Factor, was reduced. However, Exo-124 treatment did not produce significant behavioral improvement.
Conclusion
This study serves as a proof of concept for exosome-based delivery of miRNA in neurodegenerative diseases. -
Citations
Citations to this article as recorded by- The role of exosomes in adult neurogenesis: implications for neurodegenerative diseases
Zhuoyang Yu, Yan Teng, Jing Yang, Lu Yang
Neural Regeneration Research.2024; 19(2): 282. CrossRef - Exosomal microRNAs as diagnostic biomarkers and therapeutic applications in neurodegenerative diseases
Xuehereti Sataer, Zhu Qifeng, Zhang Yingying, He Chunhua, Feng Bingzhenga, Xu Zhiran, Li Wanli, Yang Yuwei, Chen Shuangfeng, Wu Lingling, Huang Hongri, Chen Jibing, Ren Xiaoping, Gao Hongjun
Neurological Research.2023; 45(3): 191. CrossRef - The role of microRNAs in neurodegenerative diseases: a review
Shijie Li, Zhixin Lei, Taolei Sun
Cell Biology and Toxicology.2023; 39(1): 53. CrossRef - Exosomes based strategies for brain drug delivery
Fawad Ur Rehman, Yang Liu, Meng Zheng, Bingyang Shi
Biomaterials.2023; 293: 121949. CrossRef - Contribution of Extracellular Vesicles and Molecular Chaperones in Age-Related Neurodegenerative Disorders of the CNS
Leila Noori, Kamila Filip, Zohreh Nazmara, Simin Mahakizadeh, Gholamreza Hassanzadeh, Celeste Caruso Bavisotto, Fabio Bucchieri, Antonella Marino Gammazza, Francesco Cappello, Maciej Wnuk, Federica Scalia
International Journal of Molecular Sciences.2023; 24(2): 927. CrossRef - Nucleic acid drug vectors for diagnosis and treatment of brain diseases
Zhi-Guo Lu, Jie Shen, Jun Yang, Jing-Wen Wang, Rui-Chen Zhao, Tian-Lu Zhang, Jing Guo, Xin Zhang
Signal Transduction and Targeted Therapy.2023;[Epub] CrossRef - Exosome-Based Carrier for RNA Delivery: Progress and Challenges
Yicheng Lu, Wei Huang, Meng Li, Aiping Zheng
Pharmaceutics.2023; 15(2): 598. CrossRef - MicroRNA‑124: an emerging therapeutic target in central nervous system disorders
Wen-Hao Zhang, Lian Jiang, Mei Li, Jing Liu
Experimental Brain Research.2023; 241(5): 1215. CrossRef - The role of exosomes in pathogenesis and the therapeutic efficacy of mesenchymal stem cell-derived exosomes against Parkinson’s disease
Maryam Abrishamdar, Maryam Sadat Jalali, Neda Yazdanfar
Neurological Sciences.2023; 44(7): 2277. CrossRef - Small Extracellular Vesicles’ miRNAs: Biomarkers and Therapeutics for Neurodegenerative Diseases
Wei Qing Lim, Kie Hoon Michelle Luk, Kah Yee Lee, Nasuha Nurul, Sin Jade Loh, Zhen Xiong Yeow, Qi Xuan Wong, Qi Hao Daniel Looi, Pan Pan Chong, Chee Wun How, Sharina Hamzah, Jhi Biau Foo
Pharmaceutics.2023; 15(4): 1216. CrossRef - Bioengineered Mesenchymal-Stromal-Cell-Derived Extracellular Vesicles as an Improved Drug Delivery System: Methods and Applications
Cristiana Ulpiano, Cláudia L. da Silva, Gabriel A. Monteiro
Biomedicines.2023; 11(4): 1231. CrossRef - Mmu-miR-25-3p promotes macrophage autophagy by targeting DUSP10 to reduce mycobacteria survival
Wenqi Yuan, Xuehua Zhan, Wei Liu, Rong Ma, Yueyong Zhou, Guangxian Xu, Zhaohui Ge
Frontiers in Cellular and Infection Microbiology.2023;[Epub] CrossRef - Exosomes in brain diseases: Pathogenesis and therapeutic targets
Qingying Si, Linlin Wu, Deshui Pang, Pei Jiang
MedComm.2023;[Epub] CrossRef - Repressor Element-1 Binding Transcription Factor (REST) as a Possible Epigenetic Regulator of Neurodegeneration and MicroRNA-Based Therapeutic Strategies
Ajmal Nassar, Sairaj Satarker, Prasada Chowdari Gurram, Dinesh Upadhya, SM Fayaz, Madhavan Nampoothiri
Molecular Neurobiology.2023; 60(10): 5557. CrossRef - Standardization Approaches for Extracellular Vesicle Loading with Oligonucleotides and Biologics
Josepha Roerig, Michaela Schulz‐Siegmund
Small.2023;[Epub] CrossRef - Small extracellular vesicles: a novel drug delivery system for neurodegenerative disorders
Renjie Pan, Dongdong Chen, Lanlan Hou, Rong Hu, Zhigang Jiao
Frontiers in Aging Neuroscience.2023;[Epub] CrossRef - Mesenchymal Stem Cell-Derived Extracellular Vesicles: An Emerging Diagnostic and Therapeutic Biomolecules for Neurodegenerative Disabilities
Mahmoud Kandeel, Mohamed A. Morsy, Khalid M. Alkhodair, Sameer Alhojaily
Biomolecules.2023; 13(8): 1250. CrossRef - Exosomes as cell-derivative carriers in the diagnosis and treatment of central nervous system diseases
Gayatri Gopal Shetgaonkar, Shirleen Miriam Marques, Cleona E. M. DCruz, R. J. A. Vibhavari, Lalit Kumar, Rupesh Kalidas Shirodkar
Drug Delivery and Translational Research.2022; 12(5): 1047. CrossRef - Emerging prospects of extracellular vesicles for brain disease theranostics
Ruoning Wang, Xiaohong Wang, Yuting Zhang, Huacong Zhao, Jiwei Cui, Junsong Li, Liuqing Di
Journal of Controlled Release.2022; 341: 844. CrossRef - Stem Cell Transplantation Therapy and Neurological Disorders: Current Status and Future Perspectives
Md. Rahman, Md. Islam, Mohammad Islam, Md. Harun-Or-Rashid, Mahfuzul Islam, Sabirin Abdullah, Mohammad Uddin, Sumit Das, Md. Rahaman, Muniruddin Ahmed, Fahad Alhumaydhi, Talha Emran, Amany Mohamed, Mohammad Faruque, Mayeen Khandaker, Gomaa Mostafa-Hedeab
Biology.2022; 11(1): 147. CrossRef - Non-viral vectors for RNA delivery
Yi Yan, Xiao-Yu Liu, An Lu, Xiang-Yu Wang, Lin-Xia Jiang, Jian-Cheng Wang
Journal of Controlled Release.2022; 342: 241. CrossRef - MicroRNA-22: a Novel and Potent Biological Therapeutics in Neurological Disorders
Seyed Hamidreza Rastegar-moghaddam, Alireza Ebrahimzadeh-Bideskan, Sara Shahba, Amir Mohammad Malvandi, Abbas Mohammadipour
Molecular Neurobiology.2022; 59(5): 2694. CrossRef - Functional Extracellular Vesicles for Regenerative Medicine
Han Young Kim, Seunglee Kwon, Wooram Um, Sol Shin, Chan Ho Kim, Jae Hyung Park, Byung‐Soo Kim
Small.2022;[Epub] CrossRef - Emerging role of exosomes in the pathology of chronic obstructive pulmonary diseases; destructive and therapeutic properties
Hadi Rajabi, Nur Konyalilar, Sinem Erkan, Deniz Mortazavi, Seval Kubra Korkunc, Ozgecan Kayalar, Hasan Bayram, Reza Rahbarghazi
Stem Cell Research & Therapy.2022;[Epub] CrossRef - MicroRNA Alteration, Application as Biomarkers, and Therapeutic Approaches in Neurodegenerative Diseases
T. P. Nhung Nguyen, Mandeep Kumar, Ernesto Fedele, Giambattista Bonanno, Tiziana Bonifacino
International Journal of Molecular Sciences.2022; 23(9): 4718. CrossRef - Protective Signature of IFNγ-Stimulated Microglia Relies on miR-124-3p Regulation From the Secretome Released by Mutant APP Swedish Neuronal Cells
Gonçalo Garcia, Adelaide Fernandes, Frank Stein, Dora Brites
Frontiers in Pharmacology.2022;[Epub] CrossRef - Therapeutic Potential of Exosomes Derived from Diabetic Adipose Stem Cells in Cutaneous Wound Healing of db/db Mice
Hsiang-Hao Hsu, Aline Yen Ling Wang, Charles Yuen Yung Loh, Ashwin Alke Pai, Huang-Kai Kao
Pharmaceutics.2022; 14(6): 1206. CrossRef - Recent progresses in exosome-based systems for targeted drug delivery to the brain
Santosh Bashyal, Chhitij Thapa, Sangkil Lee
Journal of Controlled Release.2022; 348: 723. CrossRef - MicroRNA-124 attenuates PTSD-like behaviors and reduces the level of inflammatory cytokines by downregulating the expression of TRAF6 in the hippocampus of rats following single-prolonged stress
Yao Chen, Qi An, Shu-Ting Yang, Yu-Lu Chen, Lei Tong, Li-Li Ji
Experimental Neurology.2022; 356: 114154. CrossRef - Exosomes─Nature’s Lipid Nanoparticles, a Rising Star in Drug Delivery and Diagnostics
Rumiana Tenchov, Janet M. Sasso, Xinmei Wang, Wen-Shing Liaw, Chun-An Chen, Qiongqiong Angela Zhou
ACS Nano.2022; 16(11): 17802. CrossRef - The emerging role of long non-coding RNAs, microRNAs, and an accelerated epigenetic age in Huntington’s disease
Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Mohammad Taheri, Kaveh Ebrahimzadeh, Rezvan Noroozi
Frontiers in Aging Neuroscience.2022;[Epub] CrossRef - Intracellular and intercellular transport of RNA organelles in CXG repeat disorders: The strength of weak ties
Deepti Kailash Nabariya, Annika Heinz, Sabrina Derksen, Sybille Krauß
Frontiers in Molecular Biosciences.2022;[Epub] CrossRef - Extracellular vesicles in neurodegenerative diseases: Insights and new perspectives
Qian Yuan, Xiao-dong Li, Si-miao Zhang, Hong-wei Wang, Yun-liang Wang
Genes & Diseases.2021; 8(2): 124. CrossRef - Therapeutic antisense oligonucleotides for movement disorders
Epaminondas Doxakis
Medicinal Research Reviews.2021; 41(5): 2656. CrossRef - An update on the role of miR-124 in the pathogenesis of human disorders
Soudeh Ghafouri-Fard, Hamed Shoorei, Zahra Bahroudi, Atefe Abak, Jamal Majidpoor, Mohammad Taheri
Biomedicine & Pharmacotherapy.2021; 135: 111198. CrossRef - Ancient Evolutionary Origin and Properties of Universally Produced Natural Exosomes Contribute to Their Therapeutic Superiority Compared to Artificial Nanoparticles
Phillip W. Askenase
International Journal of Molecular Sciences.2021; 22(3): 1429. CrossRef - Intriguing Biomedical Applications of Synthetic and Natural Cell-Derived Vesicles: A Comparative Overview
Brateen Datta, Debashish Paul, Uttam Pal, Tatini Rakshit
ACS Applied Bio Materials.2021; 4(4): 2863. CrossRef - Nucleic acid delivery with extracellular vesicles
Michaela Schulz-Siegmund, Achim Aigner
Advanced Drug Delivery Reviews.2021; 173: 89. CrossRef - Emerging Roles of Exosomes in Huntington’s Disease
Hanadi Ananbeh, Petr Vodicka, Helena Kupcova Skalnikova
International Journal of Molecular Sciences.2021; 22(8): 4085. CrossRef - Stem Cell-Derived Exosomes: a New Strategy of Neurodegenerative Disease Treatment
Nashmin Fayazi, Mohsen Sheykhhasan, Sara Soleimani Asl, Rezvan Najafi
Molecular Neurobiology.2021; 58(7): 3494. CrossRef - Altered microRNA expression in animal models of Huntington’s disease and potential therapeutic strategies
Bridget Martinez, PhilipV Peplow
Neural Regeneration Research.2021; 16(11): 2159. CrossRef - Roles of glia-derived extracellular vesicles in central nervous system diseases: an update
Hao Sun, Xiaojuan Su, Shiping Li, Dezhi Mu, Yi Qu
Reviews in the Neurosciences.2021; 32(8): 833. CrossRef - Oligonucleotides as therapeutic tools for brain disorders: Focus on major depressive disorder and Parkinson's disease
Analia Bortolozzi, Sharon Manashirov, Alon Chen, Francesc Artigas
Pharmacology & Therapeutics.2021; 227: 107873. CrossRef - Perspective insights and application of exosomes as a novel tool against neurodegenerative disorders: An expository appraisal
Amey Kadbhane, Monica Patel, Saurabh Srivastava, Pankaj Kumar Singh, Jitender Madan, Shashi Bala Singh, Dharmendra Kumar Khatri
Journal of Drug Delivery Science and Technology.2021; 63: 102526. CrossRef - Harnessing the therapeutic potential of extracellular vesicles for cancer treatment
Ying Zhang, Yu Xiao, Gaoge Sun, Xue Jin, Lerui Guo, Tian Li, Hang Yin
Seminars in Cancer Biology.2021; 74: 92. CrossRef - Neural Stem Cell-Derived Exosomes Regulate Neural Stem Cell Differentiation Through miR-9-Hes1 Axis
Ping Yuan, Lu Ding, Huili Chen, Yi Wang, Chunhong Li, Shu Zhao, Xiaoyu Yang, Yizhao Ma, Jie Zhu, Xinrui Qi, Yanyan Zhang, Xiaohuan Xia, Jialin C. Zheng
Frontiers in Cell and Developmental Biology.2021;[Epub] CrossRef - Diagnostic and Therapeutic Potential of Exosomal MicroRNAs for Neurodegenerative Diseases
Miao He, Hai-nan Zhang, Zhen-chu Tang, Shu-guang Gao, Laura Baroncelli
Neural Plasticity.2021; 2021: 1. CrossRef - Profiling of Extracellular Small RNAs Highlights a Strong Bias towards Non-Vesicular Secretion
Helena Sork, Mariana Conceicao, Giulia Corso, Joel Nordin, Yi Xin Fiona Lee, Kaarel Krjutskov, Jakub Orzechowski Westholm, Pieter Vader, Marie Pauwels, Roosmarijn E. Vandenbroucke, Matthew JA Wood, Samir EL Andaloussi, Imre Mäger
Cells.2021; 10(6): 1543. CrossRef - Neuroinflammation: The next target of exosomal microRNAs derived from mesenchymal stem cells in the context of neurological disorders
Mehrdad Hajinejad, Sajad Sahab‐Negah
Journal of Cellular Physiology.2021; 236(12): 8070. CrossRef - Exosomal microRNAs from mesenchymal stem/stromal cells: Biology and applications in neuroprotection
Aida Nasirishargh, Priyadarsini Kumar, Lalithasri Ramasubramanian, Kaitlin Clark, Dake Hao, Sabrina V Lazar, Aijun Wang
World Journal of Stem Cells.2021; 13(7): 776. CrossRef - Central Nervous System Cell-Derived Exosomes in Neurodegenerative Diseases
Yang Tian, Chen Fu, Yifan Wu, Yao Lu, Xuemei Liu, Yunling Zhang, Yanfang Xian
Oxidative Medicine and Cellular Longevity.2021; 2021: 1. CrossRef - The regulatory roles of microRNAs toward pathogenesis and treatments in Huntington's disease
Chih-Wei Tung, Pin-Yu Huang, Siew Chin Chan, Pei-Hsun Cheng, Shang-Hsun Yang
Journal of Biomedical Science.2021;[Epub] CrossRef - Dosing extracellular vesicles
Dhanu Gupta, Antje Maria Zickler, Samir El Andaloussi
Advanced Drug Delivery Reviews.2021; 178: 113961. CrossRef - Therapeutic Potential of Nucleic Acids when Combined with Extracellular Vesicles
Brian Jurgielewicz, Steven Stice, Yao Yao
Aging and disease.2021; 12(6): 1476. CrossRef - Effects of exosomal miRNAs in the diagnosis and treatment of Alzheimer’s disease
Guo-hong Cui, Jing Zhu, Ya-chao Wang, Jing Wu, Jian-ren Liu, Hai-dong Guo
Mechanisms of Ageing and Development.2021; 200: 111593. CrossRef - MicroRNA-124: A Key Player in Microglia-Mediated Inflammation in Neurological Diseases
Jiuhan Zhao, Zhenwei He, Jialu Wang
Frontiers in Cellular Neuroscience.2021;[Epub] CrossRef - DNAJB6b-enriched small extracellular vesicles decrease polyglutamine aggregation in in vitro and in vivo models of Huntington disease
Bhagyashree S. Joshi, Sameh A. Youssef, Reinier Bron, Alain de Bruin, Harm H. Kampinga, Inge S. Zuhorn
iScience.2021; 24(11): 103282. CrossRef - Diagnostic and Therapeutic Potential of Exosomes in Neurodegenerative Diseases
Panyue Gao, Xinrong Li, Xinzhe Du, Sha Liu, Yong Xu
Frontiers in Aging Neuroscience.2021;[Epub] CrossRef - MiR-124 and the Underlying Therapeutic Promise of Neurodegenerative Disorders
Dong Han, Xiaoyu Dong, Dongming Zheng, Jianfei Nao
Frontiers in Pharmacology.2020;[Epub] CrossRef - Circulating Exosomal miRNA as Diagnostic Biomarkers of Neurodegenerative Diseases
Lin Wang, Lijuan Zhang
Frontiers in Molecular Neuroscience.2020;[Epub] CrossRef - Current Status of microRNA-Based Therapeutic Approaches in Neurodegenerative Disorders
Sujay Paul, Luis Alberto Bravo Vázquez, Samantha Pérez Uribe, Paula Roxana Reyes-Pérez, Ashutosh Sharma
Cells.2020; 9(7): 1698. CrossRef - Progress in the molecular pathogenesis and nucleic acid therapeutics for Parkinson's disease in the precision medicine era
Dunhui Li, Frank L. Mastaglia, Sue Fletcher, Steve D. Wilton
Medicinal Research Reviews.2020; 40(6): 2650. CrossRef - MicroRNAs Dysregulation and Mitochondrial Dysfunction in Neurodegenerative Diseases
Mariano Catanesi, Michele d’Angelo, Maria Grazia Tupone, Elisabetta Benedetti, Antonio Giordano, Vanessa Castelli, Annamaria Cimini
International Journal of Molecular Sciences.2020; 21(17): 5986. CrossRef - Exosome engineering: Current progress in cargo loading and targeted delivery
Shengyang Fu, Yi Wang, Xiaohuan Xia, Jialin C. Zheng
NanoImpact.2020; 20: 100261. CrossRef - Strategies and materials of "SMART" non-viral vectors: Overcoming the barriers for brain gene therapy
Yan Li, Linying Liu, Weihong Ji, Huang Peng, Ruichen Zhao, Xin Zhang
Nano Today.2020; 35: 101006. CrossRef - Therapeutic miRNA-Enriched Extracellular Vesicles: Current Approaches and Future Prospects
Javaria Munir, Jeong Kyo Yoon, Seongho Ryu
Cells.2020; 9(10): 2271. CrossRef - The Role of Exosomal microRNAs and Oxidative Stress in Neurodegenerative Diseases
Xiaoyu Wang, Yunxiang Zhou, Qiannan Gao, Dongnan Ping, Yali Wang, Wei Wu, Xu Lin, Yuanjian Fang, Jianmin Zhang, Anwen Shao, Yanfang Xian
Oxidative Medicine and Cellular Longevity.2020; 2020: 1. CrossRef - Nanocarriers as a powerful vehicle to overcome blood-brain barrier in treating neurodegenerative diseases: Focus on recent advances
Xiaoqian Niu, Jiejian Chen, Jianqing Gao
Asian Journal of Pharmaceutical Sciences.2019; 14(5): 480. CrossRef - Blood exosomes as a tool for monitoring treatment efficacy and progression of neurodegenerative diseases
Hanin Abdel-Haq
Neural Regeneration Research.2019; 14(1): 72. CrossRef - MiR-124 Enriched Exosomes Promoted the M2 Polarization of Microglia and Enhanced Hippocampus Neurogenesis After Traumatic Brain Injury by Inhibiting TLR4 Pathway
Yongxiang Yang, Yuqin Ye, Chuiguang Kong, Xinhong Su, Xin Zhang, Wei Bai, Xiaosheng He
Neurochemical Research.2019; 44(4): 811. CrossRef - Resveratrol (3, 5, 4′-Trihydroxy-trans-Stilbene) Attenuates a Mouse Model of Multiple Sclerosis by Altering the miR-124/Sphingosine Kinase 1 Axis in Encephalitogenic T Cells in the Brain
K. Alexa Orr Gandy, Jiajia Zhang, Prakash Nagarkatti, Mitzi Nagarkatti
Journal of Neuroimmune Pharmacology.2019; 14(3): 462. CrossRef - Advances in therapeutic applications of extracellular vesicles
Oscar P. B. Wiklander, Meadhbh Á. Brennan, Jan Lötvall, Xandra O. Breakefield, Samir EL Andaloussi
Science Translational Medicine.2019;[Epub] CrossRef - Exosome-mediated therapeutic delivery: A new horizon for human neurodegenerative disorders’ treatment (with a focus on siRNA delivery improvement)
Nayer Seyfizadeh, Narges Seyfizadeh, Sajad Borzouisileh, Farideh Elahimanesh, Vahid Hosseini, Mohammad Nouri
Process Biochemistry.2019; 85: 164. CrossRef - Exosomes released from neural progenitor cells and induced neural progenitor cells regulate neurogenesis through miR-21a
Yizhao Ma, Chunhong Li, Yunlong Huang, Yi Wang, Xiaohuan Xia, Jialin C. Zheng
Cell Communication and Signaling.2019;[Epub] CrossRef - Exosomal miRNAs in central nervous system diseases: biomarkers, pathological mediators, protective factors and therapeutic agents
Xiaohuan Xia, Yi Wang, Yunlong Huang, Han Zhang, Hongfang Lu, Jialin C. Zheng
Progress in Neurobiology.2019; 183: 101694. CrossRef - Role of Exosomes in Central Nervous System Diseases
Wanying Liu, Xiaodan Bai, Ao Zhang, Juanjuan Huang, Shixin Xu, Junping Zhang
Frontiers in Molecular Neuroscience.2019;[Epub] CrossRef - miR-124 and Parkinson’s disease: A biomarker with therapeutic potential
Efthalia Angelopoulou, Yam Nath Paudel, Christina Piperi
Pharmacological Research.2019; 150: 104515. CrossRef - The Potential Role of MicroRNA-124 in Cerebral Ischemia Injury
Xiaolu Liu, Zhitao Feng, Lipeng Du, Yaguang Huang, Jinwen Ge, Yihui Deng, Zhigang Mei
International Journal of Molecular Sciences.2019; 21(1): 120. CrossRef - Epigenetic regulation of astrocyte function in neuroinflammation and neurodegeneration
Matthew Neal, Jason R. Richardson
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2018; 1864(2): 432. CrossRef - Potential of Extracellular Vesicles in Neurodegenerative Diseases: Diagnostic and Therapeutic Indications
Mehrnaz Izadpanah, Arshia Seddigh, Somayeh Ebrahimi Barough, Seyed Abolhassan Shahzadeh Fazeli, Jafar Ai
Journal of Molecular Neuroscience.2018; 66(2): 172. CrossRef - Regenerative Approaches in Huntington’s Disease: From Mechanistic Insights to Therapeutic Protocols
Jenny Sassone, Elsa Papadimitriou, Dimitra Thomaidou
Frontiers in Neuroscience.2018;[Epub] CrossRef - Exosome-based small RNA delivery: progress and prospects
Mei Lu, Haonan Xing, Zhe Xun, Tianzhi Yang, Pingtian Ding, Cuifang Cai, Dongkai Wang, Xiaoyun Zhao
Asian Journal of Pharmaceutical Sciences.2017;[Epub] CrossRef - Extracellular Vesicles in Brain Tumors and Neurodegenerative Diseases
Federica Ciregia, Andrea Urbani, Giuseppe Palmisano
Frontiers in Molecular Neuroscience.2017;[Epub] CrossRef - The miR-124 family of microRNAs is critical for regeneration of the brain and visual system in the planarian Schmidtea mediterranea
Sasidharan Vidyanand, Srujan Marepally, Sarah A. Elliott, Srishti Baid, Vairavan Lakshmanan, Nishtha Nayyar, Dhiru Bansal, Alejandro Sánchez Alvarado, Praveen Kumar Vemula, Dasaradhi Palakodeti
Development.2017;[Epub] CrossRef - Mutant Huntingtin Inhibits αB-Crystallin Expression and Impairs Exosome Secretion from Astrocytes
Yan Hong, Ting Zhao, Xiao-Jiang Li, Shihua Li
The Journal of Neuroscience.2017; 37(39): 9550. CrossRef
- The role of exosomes in adult neurogenesis: implications for neurodegenerative diseases
Review Articles
- What Is Wrong with Balance in Parkinson’s Disease?
- Jeong-Ho Park, Yeo-Jeong Kang, Fay Bahling Horak
- J Mov Disord. 2015;8(3):109-114. Published online September 10, 2015
- DOI: https://doi.org/10.14802/jmd.15018
- 23,399 View
- 385 Download
- 79 Citations
-
Abstract
PDF
- Postural instability and resulting falls are major factors determining quality of life, morbidity, and mortality in individuals with Parkinson’s disease (PD). A better understanding of balance impairments would improve management of balance dysfunction and prevent falls in patients with PD. The effects of bradykinesia, rigidity, impaired proprioception, freezing of gait and attention on postural stability in patients with idiopathic PD have been well characterized in laboratory studies. The purpose of this review is to systematically summarize the types of balance impairments contributing to postural instability in people with PD.
-
Citations
Citations to this article as recorded by- Methods for evaluating gait associated dynamic balance and coordination in rodents
Akshat D. Modi, Anavi Parekh, Zeenal H. Patel
Behavioural Brain Research.2024; 456: 114695. CrossRef - Assessing perceptions to a virtual reality intervention to improve trunk control in Parkinson’s disease: a preliminary study
Alexander Stamenkovic, Matthew Underation, Leslie J. Cloud, Peter E. Pidcoe, Mark S. Baron, Robert Hand, Christopher R. France, Susanne M. van der Veen, James S. Thomas
Virtual Reality.2023; 27(1): 465. CrossRef - Association of Depression With Early Occurrence of Postural Instability in Parkinson’s Disease
Yun Su Hwang, Sungyang Jo, Kye Won Park, Seung Hyun Lee, Sangjin Lee, Sun Ju Chung
Journal of Movement Disorders.2023; 16(1): 68. CrossRef - Clinical and MRI features of gait and balance disorders in neurodegenerative diseases
Elisabetta Sarasso, Massimo Filippi, Federica Agosta
Journal of Neurology.2023; 270(3): 1798. CrossRef - Effects of Oral Levodopa on Balance in People with Idiopathic Parkinson’s Disease
Tim Leroy, Remco J. Baggen, Nina Lefeber, Nolan Herssens, Patrick Santens, Miet De Letter, Leen Maes, Katie Bouche, Anke Van Bladel
Journal of Parkinson's Disease.2023; 13(1): 3. CrossRef - The Use of the Static Posturography to Assess Balance Performance in a Parkinson’s Disease Population
Sergio Sebastia-Amat, Juan Tortosa-Martínez, Basilio Pueo
International Journal of Environmental Research and Public Health.2023; 20(2): 981. CrossRef - Der Einfluss vom Exergaming mit kommerziell verfügbaren Spielkonsolen auf die Balance und Lebensqualität bei Menschen mit idiopathischem Parkinson-Syndrom – Eine systematische Übersichtsarbeit
Gaith Akrama, Lennert Sitzmann, Christian Baumann
physioscience.2023; 19(02): 63. CrossRef - Do cervical stabilization exercises change the effects of conventional exercises in patients with Parkinson’s disease?
Emine Nur Demircan, Nezire Köse, Gül Yalçın Çakmaklı, Songül Aksoy, Rahşan Göçmen, Hatice Yağmur Zengin, Bülent Elibol
Neurological Research.2023; 45(10): 936. CrossRef - Design of SmartWalk for Estimating Implication of Pathway With Turn and Task Condition on Postural and Gait Indices: Relevance to Fear of Fall
Priya Pallavi, Neeti Jariwala, Niravkumar Patel, Manasi Kanetkar, Shraddha Diwan, Uttama Lahiri
IEEE Transactions on Neural Systems and Rehabilitation Engineering.2023; 31: 406. CrossRef - Rehabilitation Interventions for Improving Balance in Parkinson’s Disease
Francesco Lena, Nicola Modugno, Giulio Greco, Monica Torre, Simone Cesarano, Marco Santilli, Auwal Abdullahi, Giuseppe Giovannico, Mohammad Etoom
American Journal of Physical Medicine & Rehabilitation.2023; 102(3): 270. CrossRef - Effects of Different Exercise Modes on Gait Performance of Parkinson’s Disease Patients: A Systematic Review and Network Meta-Analysis
Shi-kun Zhang, Mei-ling Gu, Hong Xu, Wen-sheng Zhou, Su-jie Mao, Yong Yang
Perceptual and Motor Skills.2023; 130(4): 1524. CrossRef - Validity and Reliability of the Thai Version of the Freezing of Gait Questionnaire in Individuals With Parkinson’s disease
Arisa Taweekitikul, Phakamas Tanvijit, Pheeravut Tantisuvanitchkul, Prachaya Srivanitchapoom, Yuvadee Pitakpatapee, Fuengfa Khobkhun, Piyapong Akkathep
Annals of Rehabilitation Medicine.2023; 47(1): 45. CrossRef - Anticipatory Postural Adjustments and Compensatory Postural Responses to Multidirectional Perturbations—Effects of Medication and Subthalamic Nucleus Deep Brain Stimulation in Parkinson’s Disease
Tobias Heß, Christian Oehlwein, Thomas L. Milani
Brain Sciences.2023; 13(3): 454. CrossRef - PRIORITIZING FALL RISK MANAGEMENT: IRRESPECTIVE OF PARKINSON’S DISEASE PROGRESSION DURING REHABILITATION
Fakhir Ansari
Pakistan Journal of Rehabilitation.2023; 12(1): 84. CrossRef - Functional balance training in people with Parkinson’s disease: a protocol of balanceHOME randomized control trial with crossover
Sara Monleón Guinot, Constanza San Martín Valenzuela, Vivina Aranda Asensi, Concepción de Salazar Antón, Manuel Villanueva Navarro, Jose M. Tomás
Frontiers in Aging Neuroscience.2023;[Epub] CrossRef - Characterizing Freezing of Gait Episodes for Parkinson’s Disease Using a Wearable Device Quantifying Gait and Posture
Priya Pallavi, Niravkumar Patel, Manasi Kanetkar, Uttama Lahiri
Journal of Medical and Biological Engineering.2023; 43(3): 266. CrossRef - Dynamic Measures of Balance during a 90° Turn in Self-Selected Gait in Individuals with Mild Parkinson’s Disease
Gordon Alderink, Cathy Harro, Lauren Hickox, David W. Zeitler, Marie Bourke, Akeya Gosla, Sarah Rustmann
Applied Sciences.2023; 13(9): 5428. CrossRef - Differences between physical therapist ratings, self-ratings, and posturographic measures when assessing static balance exercise intensity
Jamie Ferris, Jonathan Zwier, Wendy J. Carender, Kathleen H. Sienko
Frontiers in Rehabilitation Sciences.2023;[Epub] CrossRef - Validity, reliability and minimal detectable change of Mini-BESTest Turkish version in neurological disorders
Bilinc Dogruoz Karatekin, Afitap İcagasioglu, Ozge Pasin
Acta Neurologica Belgica.2023; 123(4): 1519. CrossRef - A non-expensive bidimensional kinematic balance assessment can detect early postural instability in people with Parkinson’s disease
Gabriel Venas Santos, Matheus Silva d'Alencar, Andre Frazão Helene, Antonio C. Roque, José Garcia Vivas Miranda, Maria Elisa Pimentel Piemonte
Frontiers in Neurology.2023;[Epub] CrossRef - Imbalance and gait impairment in Parkinson’s disease: discussing postural instability and ataxia
Carlos Henrique F. Camargo, Silvia Aparecida Ferreira-Peruzzo, Danieli Isabel Romanovitch Ribas, Gustavo L. Franklin, Hélio A. G. Teive
Neurological Sciences.2023;[Epub] CrossRef - Unveiling the Impact of Outpatient Physiotherapy on Specific Motor Symptoms in Parkinson’s Disease: A Prospective Cohort Study
Yuta Terasawa, Koki Ikuno, Shintaro Fujii, Yuki Nishi, Emi Tanizawa, Sachio Nabeshima, Yohei Okada
Brain & Neurorehabilitation.2023;[Epub] CrossRef - The influence of cognitive tasks on sensory organization test performance
Nathan Morelli, Nicholas R. Heebner, Courtney J. DeFeo, Matthew C. Hoch
Brazilian Journal of Otorhinolaryngology.2022; 88(6): 841. CrossRef - Influence of radial optic flow stimulation on static postural balance in Parkinson's disease: A preliminary study
Alessandro Piras, Aurelio Trofè, Andrea Meoni, Milena Raffi
Human Movement Science.2022; 81: 102905. CrossRef - The effect of Tai Chi on functional mobility, balance and falls in Parkinson's disease: A systematic review and meta-analysis of systematic reviews
Bahar Aras, Gulce Kallem Seyyar, Oznur Fidan, Ertugrul Colak
EXPLORE.2022; 18(4): 402. CrossRef - Avaliação do risco de quedas entre pessoas com doença de Parkinson
Franciny da Silva, Angela Maria Alvarez, Simony Fabíola Lopes Nunes, Maria Eduarda Massari Silva, Silvia Maria Azevedo Dos Santos
Escola Anna Nery.2022;[Epub] CrossRef - Acceptability and Preliminary Results of Technology-Assisted Balance Training in Parkinson’s Disease
Elvira Maranesi, Valentina Di Donna, Giuseppe Pelliccioni, Valentina Cameriere, Elisa Casoni, Renato Baldoni, Marco Benadduci, Nadia Rinaldi, Lorenzo Fantechi, Cinzia Giammarchi, Riccardo Luzi, Paolo Pelliccioni, Mirko Di Rosa, Pietro Scendoni, Giovanni R
International Journal of Environmental Research and Public Health.2022; 19(5): 2655. CrossRef - A systematic review on the effectiveness of perturbation-based balance training in postural control and gait in Parkinson’s disease
Daniel Boari Coelho, Claudia Eunice Neves de Oliveira, Marcos Vinicius Carvalho Guimarães, Caroline Ribeiro de Souza, Márcio Luiz dos Santos, Andrea C. de Lima-Pardini
Physiotherapy.2022; 116: 58. CrossRef - Therapeutic Implications of Caffeic Acid in Cancer and Neurological Diseases
Manzar Alam, Sarfraz Ahmed, Abdelbaset Mohamed Elasbali, Mohd Adnan, Shoaib Alam, Md. Imtaiyaz Hassan, Visweswara Rao Pasupuleti
Frontiers in Oncology.2022;[Epub] CrossRef - Rasch Validation of the Mini-BESTest in People With Parkinson Disease
Franco Franchignoni, Marco Godi, Stefano Corna, Andrea Giordano
Journal of Neurologic Physical Therapy.2022; 46(3): 219. CrossRef - Factors Contributing to Repeated Falls in Patients with Parkinsonʼs Disease : Focusing on Falls Self-efficacy and Cognition of Punishment
Yasuomi Tomii, Mika Otsuki, Naoya Hasegawa
Higher Brain Function Research.2022; 42(1): 29. CrossRef - Short-Term Motor Outcomes in Parkinson’s Disease after Subthalamic Nucleus Deep Brain Stimulation Combined with Post-Operative Rehabilitation: A Pre-Post Comparison Study
Kazunori Sato, Yoshihide Hokari, Eriko Kitahara, Nana Izawa, Kozo Hatori, Kaoru Honaga, Genko Oyama, Taku Hatano, Hirokazu Iwamuro, Atsushi Umemura, Yasushi Shimo, Nobutaka Hattori, Toshiyuki Fujiwara, Giuseppina Martella
Parkinson's Disease.2022; 2022: 1. CrossRef - Re-conceptualizing postural control assessment in sport-related concussion: Transitioning from the reflex/hierarchical model to the systems model
Thaer S. Manaseer, Douglas P. Gross, Martin Mrazik, Kathryn Schneider, Jackie L. Whittaker
Physiotherapy Theory and Practice.2021; 37(7): 763. CrossRef - Short-term effects of postural control by standing on a tilting board in patients with Parkinson’s disease
Naoya Hasegawa, Keita Ishikawa, Yuki Sato, Yasuhide Nakayama, Tadayoshi Asaka
Physiotherapy Theory and Practice.2021; 37(12): 1306. CrossRef - Comparison of the effect of whole-body vibration therapy versus conventional therapy on functional balance of patients with Parkinson’s disease: adding a mixed group
Eduardo Guadarrama-Molina, Carlos Enrique Barrón-Gámez, Ingrid Estrada-Bellmann, Jesús D. Meléndez-Flores, Paola Ramírez-Castañeda, Rosa María Gisela Hernández-Suárez, Minerva Menchaca-Pérez, Oscar Salas-Fraire
Acta Neurologica Belgica.2021; 121(3): 721. CrossRef - Impact of Physiotherapy Absence in COVID-19 Pandemic on Neurological State of Patients With Parkinson Disease
Alen Kapel, Domen Serdoner, Ester Fabiani, Tomaz Velnar
Topics in Geriatric Rehabilitation.2021; 37(1): 50. CrossRef - The relationship between attention and static balance disturbance in patients with Parkinson’s disease
Amir Dana, Amir Shams, Nahid Allafan, Alireza Bahrami
Neurological Sciences.2021; 42(12): 5107. CrossRef - Does the impaired postural control in Parkinson's disease affect the habituation to non-sequential external perturbation trials?
Victor Spiandor Beretta, Mark Gregory Carpenter, Fabio Augusto Barbieri, Paulo Cezar Rocha Santos, Diego Orcioli-Silva, Marcelo Pinto Pereira, Lilian Teresa Bucken Gobbi
Clinical Biomechanics.2021; 85: 105363. CrossRef - Abnormal center of mass feedback responses during balance: A potential biomarker of falls in Parkinson’s disease
J. Lucas McKay, Kimberly C. Lang, Sistania M. Bong, Madeleine E. Hackney, Stewart A. Factor, Lena H. Ting, Manabu Sakakibara
PLOS ONE.2021; 16(5): e0252119. CrossRef - Establishing the Rotenone-Induced Parkinson's Disease Animal Model in Wistar Albino Rats
Gangadhara Swamy, Rajendra Holla, Suresh R. Rao
Journal of Health and Allied Sciences NU.2021; 11(03): 158. CrossRef - Development of a Parkinson’s disease specific falls questionnaire
Dale M. Harris, Rachel L. Duckham, Robin M. Daly, Gavin Abbott, Liam Johnson, Timo Rantalainen, Wei-Peng Teo
BMC Geriatrics.2021;[Epub] CrossRef - Correlation between community balance and mobility scale (CB&M) with a battery of outcome measures to assess balance in Parkinson’s disease – a cross-sectional study
Ziona Lionel Dsouza, Sydney Roshan Rebello, Cherishma Dsilva
Archives of Physiotherapy.2021;[Epub] CrossRef - Cholinesterase inhibitors for gait, balance, and fall in Parkinson disease: a meta-analysis
Jia-Hung Chen, Tsai-Wei Huang, Chien-Tai Hong
npj Parkinson's Disease.2021;[Epub] CrossRef - Dancing With Parkinson's Disease: The SI-ROBOTICS Study Protocol
Roberta Bevilacqua, Marco Benadduci, Anna Rita Bonfigli, Giovanni Renato Riccardi, Giovanni Melone, Angela La Forgia, Nicola Macchiarulo, Luca Rossetti, Mauro Marzorati, Giovanna Rizzo, Pierpaolo Di Bitonto, Ada Potenza, Laura Fiorini, Federica Gabriella
Frontiers in Public Health.2021;[Epub] CrossRef - Balance and mobility in patients with newly diagnosed Parkinson’s disease – a five-year follow-up of a cohort in northern Sweden
Christer Johansson, Britta Lindström, Lars Forsgren, Gudrun M. Johansson
Disability and Rehabilitation.2020; 42(6): 770. CrossRef - Minimal Detectable Change for Balance Using the Biodex Balance System in Patients with Parkinson Disease
Jumes Leopoldino de Oliveira Lira, Carlos Ugrinowitsch, Rafael Fecchio, Daniel Boari Coelho, Acácio Moreira‐Neto, Renan Germano, Angelo Corrêa de Lima Miliatto, Bianca Cristina dos Santos Vieira Yano, Carla Silva‐Batista
PM&R.2020; 12(3): 281. CrossRef - Perception of whole-body motion during balance perturbations is impaired in Parkinson's disease and is associated with balance impairment
Sistania M. Bong, J. Lucas McKay, Stewart A. Factor, Lena H. Ting
Gait & Posture.2020; 76: 44. CrossRef - Postural impairments in Parkinson’s disease are not associated with changes in circadian rhythms changes
Luiz Claudio Zulai, André Martinez Albuquerque, Caluê Papcke, Fernando Mazzilli Louzada, Eduardo Mendonça Scheeren
Chronobiology International.2020; 37(1): 135. CrossRef - Choreographing life-experiences of balance control in people with Parkinson’s disease
Sofie LaGrone, Conran Joseph, Hanna Johansson, Birgit Enberg, Erika Franzén
BMC Neurology.2020;[Epub] CrossRef - Effect of home-based Tai Chi, Yoga or conventional balance exercise on functional balance and mobility among persons with idiopathic Parkinson’s disease: An experimental study
Arva Khuzema, A. Brammatha, V. Arul Selvan
Hong Kong Physiotherapy Journal.2020; 40(01): 39. CrossRef - A comparison of the relationship between manual dexterity and postural control in young and older individuals with Parkinson’s disease
Aybuke Cansu Kalkan, Turhan Kahraman, Biron Onur Ugut, Berril Donmez Colakoglu, Arzu Genc
Journal of Clinical Neuroscience.2020; 75: 89. CrossRef - Explaining Parkinsonian postural sway variabilities using intermittent control theory
Ranjita Dash, Vrutangkumar V. Shah, Harish J. Palanthandalam-Madapusi
Journal of Biomechanics.2020; 105: 109791. CrossRef - Rehabilitation of older people with Parkinson’s disease: an innovative protocol for RCT study to evaluate the potential of robotic-based technologies
Roberta Bevilacqua, Elvira Maranesi, Mirko Di Rosa, Riccardo Luzi, Elisa Casoni, Nadia Rinaldi, Renato Baldoni, Fabrizia Lattanzio, Valentina Di Donna, Giuseppe Pelliccioni, Giovanni Renato Riccardi
BMC Neurology.2020;[Epub] CrossRef - Assessment of Functional Activities in Individuals with Parkinson’s Disease Using a Simple and Reliable Smartphone-Based Procedure
Pilar Serra-Añó, José Francisco Pedrero-Sánchez, Marta Inglés, Marta Aguilar-Rodríguez, Ismael Vargas-Villanueva, Juan López-Pascual
International Journal of Environmental Research and Public Health.2020; 17(11): 4123. CrossRef - New insight into Parkinson’s disease‐related impairment of the automatic control of upright stance
Cédrick T. Bonnet, Arnaud Delval, Tarkeshwar Singh, Yann‐Romain Kechabia, Luc Defebvre
European Journal of Neuroscience.2020; 52(12): 4851. CrossRef - Innovative Parkinson's Disease Patients' Motor Skills Assessment: The i-PROGNOSIS Paradigm
Sofia Balula Dias, Athina Grammatikopoulou, José Alves Diniz, Kosmas Dimitropoulos, Nikos Grammalidis, Vicky Zilidou, Theodore Savvidis, Evdokimos Konstantinidis, Panagiotis D. Bamidis, Hagen Jaeger, Michael Stadtschnitzer, Hugo Silva, Gonçalo Telo, Ioann
Frontiers in Computer Science.2020;[Epub] CrossRef - Effects of multimodal balance training supported by rhythmical auditory stimuli in people with advanced stages of Parkinson's disease: a pilot randomized clinical trial
Tamine T.C. Capato, Jorik Nonnekes, Nienke M. de Vries, Joanna IntHout, Egberto R. Barbosa, Bastiaan R. Bloem
Journal of the Neurological Sciences.2020; 418: 117086. CrossRef - Responsiveness of Objective vs. Clinical Balance Domain Outcomes for Exercise Intervention in Parkinson's Disease
Naoya Hasegawa, Vrutangkumar V. Shah, Graham Harker, Patricia Carlson-Kuhta, John G. Nutt, Jodi A. Lapidus, Se Hee Jung, Nancy Barlow, Laurie A. King, Fay B. Horak, Martina Mancini
Frontiers in Neurology.2020;[Epub] CrossRef - Neuroprotective Effects of Coffee Bioactive Compounds: A Review
Katarzyna Socała, Aleksandra Szopa, Anna Serefko, Ewa Poleszak, Piotr Wlaź
International Journal of Molecular Sciences.2020; 22(1): 107. CrossRef - Parkinson's Disease and Parkinsonism
Michael T. Hayes
The American Journal of Medicine.2019; 132(7): 802. CrossRef - How to Select Balance Measures Sensitive to Parkinson’s Disease from Body-Worn Inertial Sensors—Separating the Trees from the Forest
Naoya Hasegawa, Vrutangkumar V. Shah, Patricia Carlson-Kuhta, John G. Nutt, Fay B. Horak, Martina Mancini
Sensors.2019; 19(15): 3320. CrossRef - Treatment options for postural instability and gait difficulties in Parkinson’s disease
Martijn L.T.M. Müller, Uros Marusic, Miriam van Emde Boas, Daniel Weiss, Nicolaas I. Bohnen
Expert Review of Neurotherapeutics.2019; 19(12): 1229. CrossRef - A new technique to test the effect of cognition on standing balance in Parkinson’s disease
M Bhatt, B Mahana, JJ Marotta, JH Ko, T Szturm
Open Journal of Parkinson's Disease and Treatment.2019; 2(1): 006. CrossRef - Step length determines minimum toe clearance in older adults and people with Parkinson’s disease
Lisa Alcock, Brook Galna, Ruth Perkins, Sue Lord, Lynn Rochester
Journal of Biomechanics.2018; 71: 30. CrossRef - Long-term effects of highly challenging balance training in Parkinson’s disease—a randomized controlled trial
Martin Benka Wallén, Maria Hagströmer, David Conradsson, Kimmo Sorjonen, Erika Franzén
Clinical Rehabilitation.2018; : 026921551878433. CrossRef - Parkinson's disease versus ageing: different postural responses to soleus muscle vibration
Diana Bzdúšková, Peter Valkovič, Zuzana Hirjaková, Jana Kimijanová, František Hlavačka
Gait & Posture.2018; 65: 169. CrossRef - A High-Intensity Multicomponent Agility Intervention Improves Parkinson Patients’ Clinical and Motor Symptoms
József Tollár, Ferenc Nagy, Norbert Kovács, Tibor Hortobágyi
Archives of Physical Medicine and Rehabilitation.2018; 99(12): 2478. CrossRef - Parkinson’s disease does not alter automatic visual-motor coupling in postural control
Caio Ferraz Cruz, Maria Elisa Pimentel Piemonte, Líria Akie Okai-Nobrega, Erika Okamoto, Ana Claudia de Souza Fortaleza, Martina Mancini, Fay Bahling Horak, José Angelo Barela
Neuroscience Letters.2018; 686: 47. CrossRef - Assessing Walking Adaptability in Parkinson's Disease: “The Interactive Walkway”
Daphne J. Geerse, Melvyn Roerdink, Johan Marinus, Jacobus J. van Hilten
Frontiers in Neurology.2018;[Epub] CrossRef - Camptocormia with Transient Ischemic Attack
Ju-Hee Oh, Dong-Woo Ryu, Si-Hoon Lee, Joong-Seok Kim
Journal of Movement Disorders.2017; 10(1): 62. CrossRef - Motor dysfunction and alterations in glutathione concentration, cholinesterase activity, and BDNF expression in substantia nigra pars compacta in rats with pedunculopontine lesion
Lisette Blanco-Lezcano, Javier Jimenez-Martin, Mei-Li Díaz-Hung, Esteban Alberti-Amador, Maylin Wong-Guerra, Ma. Elena González-Fraguela, Bárbara Estupiñán-Díaz, Teresa Serrano-Sánchez, Liliana Francis-Turner, Susana Delgado-Ocaña, Yanier Núñez-Figueredo,
Neuroscience.2017; 348: 83. CrossRef - Axial rigidity is related to the risk of falls in patients with Parkinson’s disease
Roberto Cano-de-la-Cuerda, Lydia Vela-Desojo, Juan Carlos Miangolarra-Page, Yolanda Macías-Macías
NeuroRehabilitation.2017; 40(4): 569. CrossRef - Body Posture, Postural Stability, and Metabolic Age in Patients with Parkinson’s Disease
Jacek Wilczyński, Agnieszka Pedrycz, Dariusz Mucha, Tadeusz Ambroży, Dawid Mucha
BioMed Research International.2017; 2017: 1. CrossRef - Investigation of Anticipatory Postural Adjustments during One-Leg Stance Using Inertial Sensors: Evidence from Subjects with Parkinsonism
Gianluca Bonora, Martina Mancini, Ilaria Carpinella, Lorenzo Chiari, Maurizio Ferrarin, John G. Nutt, Fay B. Horak
Frontiers in Neurology.2017;[Epub] CrossRef - Altered neurofilament protein expression in the lateral vestibular nucleus in Parkinson’s disease
Thomas P. Wellings, Alan M. Brichta, Rebecca Lim
Experimental Brain Research.2017; 235(12): 3695. CrossRef - Biomechanical Analysis of Dance for Parkinson’s Disease: A Paradoxical Case Study of Balance and Gait Effects?
Kristen L. Sowalsky, Jill Sonke, Lori J.P. Altmann, Leonardo Almeida, Chris J. Hass
EXPLORE.2017; 13(6): 409. CrossRef - Femur Fractures in Parkinsonism: Analysis of a National Sample Cohort in South Korea
Soo Jeong An, Seung-Hwan Lee, Seo-Young Lee, Jae-Woo Kwon, Seung-Joon Lee, Young-Ju Kim
Journal of Clinical Neurology.2017; 13(4): 380. CrossRef - The International Classification of Functioning, Disability and Health as Applied to Parkinson’s Disease: A Literature Review
Audrin Said Vojciechowski, Talita Gianello Gnoato Zotz, Ana Paula Cunha Loureiro, Vera Lúcia Israel
Advances in Parkinson's Disease.2016; 05(02): 29. CrossRef - Can Gait Signatures Provide Quantitative Measures for Aiding Clinical Decision-Making? A Systematic Meta-Analysis of Gait Variability Behavior in Patients with Parkinson's Disease
Niklas König, Navrag B. Singh, Christian R. Baumann, William R. Taylor
Frontiers in Human Neuroscience.2016;[Epub] CrossRef
- Methods for evaluating gait associated dynamic balance and coordination in rodents
- Altered Gut Microbiome and Intestinal Pathology in Parkinson’s Disease
- Han-Lin Chiang, Chin-Hsien Lin
- J Mov Disord. 2019;12(2):67-83. Published online May 30, 2019
- DOI: https://doi.org/10.14802/jmd.18067
- 14,860 View
- 738 Download
- 62 Citations
-
Abstract
PDF
- Parkinson’s disease (PD) is a common neurodegenerative disorder arising from an interplay between genetic and environmental risk factors. Studies have suggested that the pathological hallmarks of intraneuronal α-synuclein aggregations may start from the olfactory bulb and the enteric nervous system of the gut and later propagate to the brain via the olfactory tract and the vagus nerve. This hypothesis correlates well with clinical symptoms, such as constipation, that may develop up to 20 years before the onset of PD motor symptoms. Recent interest in the gut–brain axis has led to vigorous research into the gastrointestinal pathology and gut microbiota changes in patients with PD. In this review, we provide current clinical and pathological evidence of gut involvement in PD by summarizing the changes in gut microbiota composition and gut inflammation associated with its pathogenesis.
-
Citations
Citations to this article as recorded by- Adipose tissue, systematic inflammation, and neurodegenerative diseases
AnaPaula de A. Boleti, PedroHenrique de O. Cardoso, BrenoEmanuel F. Frihling, PatríciaSouza e Silva, LuizFilipe R. N. de Moraes, Ludovico Migliolo
Neural Regeneration Research.2023; 18(1): 38. CrossRef - Parkinson's Disease: A Multisystem Disorder
Helena Nunes Costa, Ana Raquel Esteves, Nuno Empadinhas, Sandra Morais Cardoso
Neuroscience Bulletin.2023; 39(1): 113. CrossRef - Brain modulation by the gut microbiota: From disease to therapy
Sarmistha Mitra, Raju Dash, Amena Al Nishan, Sarmin Ummey Habiba, Il Soo Moon
Journal of Advanced Research.2023; 53: 153. CrossRef - Plasma Metabolic Analysis Reveals the Dysregulation of Short-Chain Fatty Acid Metabolism in Parkinson’s Disease
Ao Qi, Lulu Liu, Junjie Zhang, Simei Chen, Simin Xu, Yusen Chen, Lijiang Zhang, Chun Cai
Molecular Neurobiology.2023; 60(5): 2619. CrossRef - Fecal microbiota transplantation in Parkinson's disease—A randomized repeat-dose, placebo-controlled clinical pilot study
Herbert L. DuPont, Jessika Suescun, Zhi-Dong Jiang, Eric L. Brown, Heather T. Essigmann, Ashley S. Alexander, Andrew W. DuPont, Tehseen Iqbal, Netanya S. Utay, Michael Newmark, Mya C. Schiess
Frontiers in Neurology.2023;[Epub] CrossRef - Mesoporous silica nanoparticles: Their potential as drug delivery carriers and nanoscavengers in Alzheimer's and Parkinson's diseases
Mohamed S. Attia, Ahmed Yahya, Nada Abdel Monaem, Shereen A. Sabry
Saudi Pharmaceutical Journal.2023; 31(3): 417. CrossRef - GSDMD in peripheral myeloid cells regulates microglial immune training and neuroinflammation in Parkinson's disease
Bingwei Wang, Yan Ma, Sheng Li, Hang Yao, Mingna Gu, Ying Liu, You Xue, Jianhua Ding, Chunmei Ma, Shuo Yang, Gang Hu
Acta Pharmaceutica Sinica B.2023; 13(6): 2663. CrossRef - Gut-microbiome-brain axis: the crosstalk between the vagus nerve, alpha-synuclein and the brain in Parkinson’s disease
Júlio César Claudino dos Santos, Leandro Freitas Oliveira, Felipe Micelli Noleto, Camilla Teixeira Pinheiro Gusmão, Gerly Anne de Castro Brito, Glauce Socorro de Barros Viana
Neural Regeneration Research.2023; 18(12): 2611. CrossRef - Beyond the Microbiota: Understanding the Role of the Enteric Nervous System in Parkinson’s Disease from Mice to Human
Martina Montanari, Paola Imbriani, Paola Bonsi, Giuseppina Martella, Antonella Peppe
Biomedicines.2023; 11(6): 1560. CrossRef - Effects of gut microbiota on neurodegenerative diseases
Saima Khatoon, Nida Kalam, Summya Rashid, Gulnaz Bano
Frontiers in Aging Neuroscience.2023;[Epub] CrossRef - From-Toilet-to-Freezer: A Review on Requirements for an Automatic Protocol to Collect and Store Human Fecal Samples for Research Purposes
Frances Widjaja, Ivonne M. C. M. Rietjens
Biomedicines.2023; 11(10): 2658. CrossRef - Association between the risk and severity of Parkinson’s disease and plasma homocysteine, vitamin B12 and folate levels: a systematic review and meta-analysis
Yuxin Quan, Jisen Xu, Qing Xu, Zhiqing Guo, Ruwei Ou, Huifang Shang, Qianqian Wei
Frontiers in Aging Neuroscience.2023;[Epub] CrossRef - Oral pathogens exacerbate Parkinson’s disease by promoting Th1 cell infiltration in mice
Xue-Bing Bai, Shuo Xu, Lu-Jun Zhou, Xiao-Qian Meng, Yu-Lin Li, Yan-Lin Chen, Yi-Han Jiang, Wen-Zhen Lin, Bo-Yan Chen, Lin-Juan Du, Guo-Cai Tian, Yan Liu, Sheng-Zhong Duan, Ya-Qin Zhu
Microbiome.2023;[Epub] CrossRef - The intestinal luminal sources of α-synuclein: a gastroenterologist perspective
Aaron Lerner
Nutrition Reviews.2022; 80(2): 282. CrossRef - Mild Chronic Colitis Triggers Parkinsonism in LRRK2 Mutant Mice Through Activating TNF‐α Pathway
Chin‐Hsien Lin, Han‐Yi Lin, En‐Pong Ho, Yi‐Ci Ke, Mei‐Fang Cheng, Chyng‐Yann Shiue, Chi‐Han Wu, Peng‐Hsiang Liao, Angela Yu‐Huey Hsu, Li‐An Chu, Ya‐Ding Liu, Ya‐Hui Lin, Yi‐Cheng Tai, Chia‐Tung Shun, Han‐Mo Chiu, Ming‐Shiang Wu
Movement Disorders.2022; 37(4): 745. CrossRef - Digesting recent findings: gut alpha-synuclein, microbiome changes in Parkinson’s disease
Ehraz Anis, Aoji Xie, Lena Brundin, Patrik Brundin
Trends in Endocrinology & Metabolism.2022; 33(2): 147. CrossRef - Animal models of brain-first and body-first Parkinson's disease
Nathalie Van Den Berge, Ayse Ulusoy
Neurobiology of Disease.2022; 163: 105599. CrossRef - Microbiome Changes in Humans with Parkinson’s Disease after Photobiomodulation Therapy: A Retrospective Study
Brian Bicknell, Ann Liebert, Craig S. McLachlan, Hosen Kiat
Journal of Personalized Medicine.2022; 12(1): 49. CrossRef - Passive Immunization in Alpha-Synuclein Preclinical Animal Models
Jonas Folke, Nelson Ferreira, Tomasz Brudek, Per Borghammer, Nathalie Van Den Berge
Biomolecules.2022; 12(2): 168. CrossRef - Dietary Succinoglycan Riclin Improves Glycemia Control in Mice with Type 2 Diabetes
Zhao Ding, Yang Zhao, Junhao Liu, Wenhao Ge, Xi Xu, Shiming Wang, Jianfa Zhang
Journal of Agricultural and Food Chemistry.2022; 70(6): 1819. CrossRef - Role of Microbiota-Gut-Brain Axis in Regulating Dopaminergic Signaling
Sevag Hamamah, Armin Aghazarian, Anthony Nazaryan, Andras Hajnal, Mihai Covasa
Biomedicines.2022; 10(2): 436. CrossRef - Distribution of α-Synuclein Aggregation in the Peripheral Tissues
Yan-yan Li, Tian-tian Zhou, Yi Zhang, Nai-Hong Chen, Yu-He Yuan
Neurochemical Research.2022; 47(12): 3627. CrossRef - Effects of Subdiaphragmatic Vagotomy in the MPTP-induced Neurotoxicity in the Striatum and Colon of Mice
Jiajing Shan, Youge Qu, Jiancheng Zhang, Li Ma, Kenji Hashimoto
Clinical Psychopharmacology and Neuroscience.2022; 20(2): 389. CrossRef - Alpha-Synuclein Strain Variability in Body-First and Brain-First Synucleinopathies
Mie Kristine Just, Hjalte Gram, Vasileios Theologidis, Poul Henning Jensen, K. Peter R. Nilsson, Mikael Lindgren, Karoline Knudsen, Per Borghammer, Nathalie Van Den Berge
Frontiers in Aging Neuroscience.2022;[Epub] CrossRef - Urolithins: potential biomarkers of gut dysbiosis and disease stage in Parkinson's patients
María Romo-Vaquero, Emiliano Fernández-Villalba, Ana-Luisa Gil-Martinez, Lorena Cuenca-Bermejo, Juan Carlos Espín, María Trinidad Herrero, María Victoria Selma
Food & Function.2022; 13(11): 6306. CrossRef - Short chain fatty acids-producing and mucin-degrading intestinal bacteria predict the progression of early Parkinson’s disease
Hiroshi Nishiwaki, Mikako Ito, Tomonari Hamaguchi, Tetsuya Maeda, Kenichi Kashihara, Yoshio Tsuboi, Jun Ueyama, Takumi Yoshida, Hiroyuki Hanada, Ichiro Takeuchi, Masahisa Katsuno, Masaaki Hirayama, Kinji Ohno
npj Parkinson's Disease.2022;[Epub] CrossRef - Opicapone, a Novel Catechol-O-methyl Transferase Inhibitor, for Treatment of Parkinson’s Disease “Off” Episodes
Amnon A. Berger, Ariel Winnick, Jonathan Izygon, Binil M. Jacob, Jessica S. Kaye, Rachel J. Kaye, Elisa E. Neuchat, Adam M. Kaye, Edward S. Alpaugh, Elyse M. Cornett, Andrew H. Han, Alan D. Kaye
Health Psychology Research.2022;[Epub] CrossRef - The role of LRRK2 in the periphery: link with Parkinson's disease and inflammatory diseases
George Tsafaras, Veerle Baekelandt
Neurobiology of Disease.2022; 172: 105806. CrossRef - What Is the Prognostic Significance of Rapid Eye Movement Sleep Without Atonia in a Polysomnogram?
Frank Ralls, Lisa Cutchen, Madeleine M. Grigg-Damberger
Journal of Clinical Neurophysiology.2022; 39(5): 346. CrossRef - Lippia grata essential oil complexed with β-cyclodextrin ameliorates biochemical and behavioral deficits in an animal model of progressive parkinsonism
Jose Ivo A. Beserra-Filho, Amanda Maria-Macêdo, Suellen Silva-Martins, Ana Cláudia Custódio-Silva, Beatriz Soares-Silva, Sara Pereira Silva, Rafael Herling Lambertucci, Adriano Antunes de Souza Araújo, Angélica Maria Lucchese, Lucindo J. Quintans-Júnior,
Metabolic Brain Disease.2022; 37(7): 2331. CrossRef - Oral and gut dysbiosis leads to functional alterations in Parkinson’s disease
Sungyang Jo, Woorim Kang, Yun Su Hwang, Seung Hyun Lee, Kye Won Park, Mi Sun Kim, Hyunna Lee, Hyung Jeong Yoon, Yoo Kyoung Park, Mauricio Chalita, Je Hee Lee, Hojun Sung, Jae-Yun Lee, Jin-Woo Bae, Sun Ju Chung
npj Parkinson's Disease.2022;[Epub] CrossRef - Deciphering Intertwined Molecular Pathways Underlying Metabolic Syndrome Leading to Parkinson’s Disease
Ritu Soni, Jigna Shah
ACS Chemical Neuroscience.2022; 13(15): 2240. CrossRef - Therapeutic potential of short-chain fatty acid production by gut microbiota in neurodegenerative disorders
Sarika Yadav, Ashish Dwivedi, Anurag Tripathi, Amit Kumar Tripathi
Nutrition Research.2022; 106: 72. CrossRef - Development of neurodegenerative disorders and the role of gut
Woong-Woo Lee
Journal of Geriatric Neurology.2022; 1(2): 53. CrossRef - What Are the Key Gut Microbiota Involved in Neurological Diseases? A Systematic Review
Bruno Bonnechère, Najaf Amin, Cornelia van Duijn
International Journal of Molecular Sciences.2022; 23(22): 13665. CrossRef - Gut microbiota in dementia with Lewy bodies
Hiroshi Nishiwaki, Jun Ueyama, Kenichi Kashihara, Mikako Ito, Tomonari Hamaguchi, Tetsuya Maeda, Yoshio Tsuboi, Masahisa Katsuno, Masaaki Hirayama, Kinji Ohno
npj Parkinson's Disease.2022;[Epub] CrossRef - Gut dysbiosis in stroke and its implications on Alzheimer’s disease‐like cognitive dysfunction
Justin Cho, You Jeong Park, Bella Gonzales‐Portillo, Madeline Saft, Blaise Cozene, Nadia Sadanandan, Cesar V. Borlongan
CNS Neuroscience & Therapeutics.2021; 27(5): 505. CrossRef - Plasma Lipopolysaccharide-Binding Protein Reflects Risk and Progression of Parkinson’s Disease
Szu-Ju Chen, Yu-Chiao Chi, Chang-Han Ho, Wei-Shiung Yang, Chin-Hsien Lin
Journal of Parkinson's Disease.2021; 11(3): 1129. CrossRef - Parkinson's disease and the gut: Models of an emerging relationship
Adam J. Bindas, Subhash Kulkarni, Ryan A. Koppes, Abigail N. Koppes
Acta Biomaterialia.2021; 132: 325. CrossRef - Ageing promotes pathological alpha-synuclein propagation and autonomic dysfunction in wild-type rats
Nathalie Van Den Berge, Nelson Ferreira, Trine Werenberg Mikkelsen, Aage Kristian Olsen Alstrup, Gültekin Tamgüney, Páll Karlsson, Astrid Juhl Terkelsen, Jens Randel Nyengaard, Poul Henning Jensen, Per Borghammer
Brain.2021; 144(6): 1853. CrossRef - Desulfovibrio Bacteria Are Associated With Parkinson’s Disease
Kari E. Murros, Vy A. Huynh, Timo M. Takala, Per E. J. Saris
Frontiers in Cellular and Infection Microbiology.2021;[Epub] CrossRef - “Janus-Faced” α-Synuclein: Role in Parkinson’s Disease
Bipul Ray, Arehally M. Mahalakshmi, Sunanda Tuladhar, Abid Bhat, Asha Srinivasan, Christophe Pellegrino, Anbarasu Kannan, Srinivasa Rao Bolla, Saravana Babu Chidambaram, Meena Kishore Sakharkar
Frontiers in Cell and Developmental Biology.2021;[Epub] CrossRef - Influence of probiotic bacteria on gut microbiota composition and gut wall function in an in-vitro model in patients with Parkinson's disease
Jonas Ghyselinck, Lynn Verstrepen, Frédéric Moens, Pieter Van Den Abbeele, Arnout Bruggeman, Jawal Said, Barry Smith, Lynne Ann Barker, Caroline Jordan, Valentina Leta, K. Ray Chaudhuri, Abdul W. Basit, Simon Gaisford
International Journal of Pharmaceutics: X.2021; 3: 100087. CrossRef - The Role of The Gut Microbiome in Parkinson’s Disease
Amy Gallop, James Weagley, Saif-ur-Rahman Paracha, George Grossberg
Journal of Geriatric Psychiatry and Neurology.2021; 34(4): 253. CrossRef - The Baseline Structure of the Enteric Nervous System and Its Role in Parkinson’s Disease
Gianfranco Natale, Larisa Ryskalin, Gabriele Morucci, Gloria Lazzeri, Alessandro Frati, Francesco Fornai
Life.2021; 11(8): 732. CrossRef - Regulation of neurotoxicity in the striatum and colon of MPTP-induced Parkinson’s disease mice by gut microbiome
Jiajing Shan, Youge Qu, Siming Wang, Yan Wei, Lijia Chang, Li Ma, Kenji Hashimoto
Brain Research Bulletin.2021; 177: 103. CrossRef - Cholecystectomy and subsequent risk of Parkinson’s disease: a nationwide retrospective cohort study
Ryul Kim, Jee-Young Lee, Sanghyun Park, Kyungdo Han, Cheol Min Shin
npj Parkinson's Disease.2021;[Epub] CrossRef - Benefits of Helicobacter pylori Eradication on Extragastric Diseases
Tae Jun Kim, Hyuk Lee
The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2021; 21(4): 275. CrossRef - Higher cerebrospinal fluid to plasma ratio of p-cresol sulfate and indoxyl sulfate in patients with Parkinson’s disease
Bartłomiej Sankowski, Karolina Księżarczyk, Emilia Raćkowska, Stanisław Szlufik, Dariusz Koziorowski, Joanna Giebułtowicz
Clinica Chimica Acta.2020; 501: 165. CrossRef - The microbiome-gut-brain axis in acute and chronic brain diseases
Corinne Benakis, Camille Martin-Gallausiaux, Jean-Pierre Trezzi, Philip Melton, Arthur Liesz, Paul Wilmes
Current Opinion in Neurobiology.2020; 61: 1. CrossRef - The progress of gut microbiome research related to brain disorders
Sibo Zhu, Yanfeng Jiang, Kelin Xu, Mei Cui, Weimin Ye, Genming Zhao, Li Jin, Xingdong Chen
Journal of Neuroinflammation.2020;[Epub] CrossRef - Minireview on the Relations between Gut Microflora and Parkinson’s Disease: Further Biochemical (Oxidative Stress), Inflammatory, and Neurological Particularities
Ovidiu-Dumitru Ilie, Alin Ciobica, Jack McKenna, Bogdan Doroftei, Ioannis Mavroudis, Tuane B. Sampaio
Oxidative Medicine and Cellular Longevity.2020; 2020: 1. CrossRef - Microbiota-gut-brain axis in health and disease: Is NLRP3 inflammasome at the crossroads of microbiota-gut-brain communications?
Carolina Pellegrini, Luca Antonioli, Vincenzo Calderone, Rocchina Colucci, Matteo Fornai, Corrado Blandizzi
Progress in Neurobiology.2020; 191: 101806. CrossRef - Meta‐Analysis of Gut Dysbiosis in Parkinson's Disease
Hiroshi Nishiwaki, Mikako Ito, Tomohiro Ishida, Tomonari Hamaguchi, Tetsuya Maeda, Kenichi Kashihara, Yoshio Tsuboi, Jun Ueyama, Teppei Shimamura, Hiroshi Mori, Ken Kurokawa, Masahisa Katsuno, Masaaki Hirayama, Kinji Ohno
Movement Disorders.2020; 35(9): 1626. CrossRef - In Search of Effective Treatments Targeting α-Synuclein Toxicity in Synucleinopathies: Pros and Cons
Maria Fouka, Panagiota Mavroeidi, Grigoria Tsaka, Maria Xilouri
Frontiers in Cell and Developmental Biology.2020;[Epub] CrossRef - Role of Carbon Monoxide in Host–Gut Microbiome Communication
Christopher P. Hopper, Ladie Kimberly De La Cruz, Kristin V. Lyles, Lauren K. Wareham, Jack A. Gilbert, Zehava Eichenbaum, Marcin Magierowski, Robert K. Poole, Jakob Wollborn, Binghe Wang
Chemical Reviews.2020; 120(24): 13273. CrossRef - Neurodegeneration and Inflammation—An Interesting Interplay in Parkinson’s Disease
Chrysoula Marogianni, Maria Sokratous, Efthimios Dardiotis, Georgios M. Hadjigeorgiou, Dimitrios Bogdanos, Georgia Xiromerisiou
International Journal of Molecular Sciences.2020; 21(22): 8421. CrossRef - Niacin and Butyrate: Nutraceuticals Targeting Dysbiosis and Intestinal Permeability in Parkinson’s Disease
Tennekoon B. Karunaratne, Chijioke Okereke, Marissa Seamon, Sharad Purohit, Chandramohan Wakade, Amol Sharma
Nutrients.2020; 13(1): 28. CrossRef - Short-Chain Fatty Acid-Producing Gut Microbiota Is Decreased in Parkinson’s Disease but Not in Rapid-Eye-Movement Sleep Behavior Disorder
Hiroshi Nishiwaki, Tomonari Hamaguchi, Mikako Ito, Tomohiro Ishida, Tetsuya Maeda, Kenichi Kashihara, Yoshio Tsuboi, Jun Ueyama, Teppei Shimamura, Hiroshi Mori, Ken Kurokawa, Masahisa Katsuno, Masaaki Hirayama, Kinji Ohno, Chaysavanh Manichanh
mSystems.2020;[Epub] CrossRef - The Intestinal Barrier in Parkinson’s Disease: Current State of Knowledge
Sven C. D. van IJzendoorn, Pascal Derkinderen, Teus van Laar
Journal of Parkinson's Disease.2019; 9(s2): S323. CrossRef - Medical management, prevention and mitigation of environmental risks factors in Neurology
J. Reis, G.C. Román, M. Giroud, V.S. Palmer, P.S. Spencer
Revue Neurologique.2019; 175(10): 698. CrossRef - Antibiotic-induced microbiome depletion protects against MPTP-induced dopaminergic neurotoxicity in the brain
Yaoyu Pu, Lijia Chang, Youge Qu, Siming Wang, Kai Zhang, Kenji Hashimoto
Aging.2019; 11(17): 6915. CrossRef
- Adipose tissue, systematic inflammation, and neurodegenerative diseases
- Episodic Ataxias: Clinical and Genetic Features
- Kwang-Dong Choi, Jae-Hwan Choi
- J Mov Disord. 2016;9(3):129-135. Published online September 21, 2016
- DOI: https://doi.org/10.14802/jmd.16028
- 22,923 View
- 861 Download
- 58 Citations
-
Abstract
PDF
- Episodic ataxia (EA) is a clinically heterogeneous group of disorders that are characterized by recurrent spells of truncal ataxia and incoordination lasting minutes to hours. Most have an autosomal dominant inheritance pattern. To date, 8 subtypes have been defined according to clinical and genetic characteristics, and five genes are known to be linked to EAs. Both EA1 and EA2, which are caused by mutations in KCNA1 and CACNA1A, account for the majority of EA, but many patients with no identified mutations still exhibit EA-like clinical features. Furthermore, genetically confirmed EAs have mostly been identified in Caucasian families. In this article, we review the current knowledge on the clinical and genetic characteristics of EAs. Additionally, we summarize the phenotypic features of the genetically confirmed EA2 families in Korea.
-
Citations
Citations to this article as recorded by- Ataxien – Eine aktuelle Übersicht über die weiter wachsende Anzahl möglicher Diagnosen
Andreas Thieme, Dagmar Timmann
Neuroradiologie Scan.2023; 13(01): 63. CrossRef - Zerebellärer Schwindel, was steckt dahinter?
Katharina Feil, Tim W. Rattay, Adedolapo Kamaldeen Adeyemi, Nicolina Goldschagg, Michael Strupp
Nervenheilkunde.2023; 42(01/02): 37. CrossRef - Ataxias: Hereditary, Acquired, and Reversible Etiologies
Chi-Ying R. Lin, Sheng-Han Kuo
Seminars in Neurology.2023; 43(01): 048. CrossRef - SCN2A- Associated Episodic and Persistent Ataxia with Cerebellar Atrophy: A Case Report
Maeve Murray, Jaclyn M. Martindale, Scott I. Otallah
Child Neurology Open.2023; 10: 2329048X2311639. CrossRef - Episodic Ataxias: Primary and Secondary Etiologies, Treatment, and Classification Approaches
Anhar Hassan
Tremor and Other Hyperkinetic Movements.2023;[Epub] CrossRef - Novel Genetic Variants Expand the Functional, Molecular, and Pathological Diversity of KCNA1 Channelopathy
Kelsey Paulhus, Edward Glasscock
International Journal of Molecular Sciences.2023; 24(10): 8826. CrossRef - kcna1a mutant zebrafish model episodic ataxia type 1 (EA1) with epilepsy and show response to first‐line therapy carbamazepine
Deepika Dogra, Paola L. Meza‐Santoscoy, Cezar Gavrilovici, Renata Rehak, Cristiane L. R. de la Hoz, Kingsley Ibhazehiebo, Jong M. Rho, Deborah M. Kurrasch
Epilepsia.2023; 64(8): 2186. CrossRef - A Review of Current and Prospective Treatments for Channelopathies, with a Focus on Gene and Protein Therapy
Monica Sakla, Ulrike Breitinger, Hans-Georg Breitinger, Samar Mansour, Salma Nabil Tammam
Current Pharmaceutical Design.2023; 29(17): 1341. CrossRef - Clinical and VEMPS Characteristics of Benign Recurrent Vertigo With Cochlear Symptoms and Migraine
Xue Zhang, Bo Xu, Yuanquan Li, Yunsheng Wu, Hongbin Yang, Ziming Wu
Ear, Nose & Throat Journal.2023;[Epub] CrossRef - Episodic ataxias
Ján Necpál, Mária Holá, Bibiána Jeleňová, Marcel Árvai
Neurologie pro praxi.2023; 24(4): 253. CrossRef - Case report: Episodic ataxia without ataxia?
Andrea Gaudio, Fabio Gotta, Clarissa Ponti, Francesca Sanguineri, Lucia Trevisan, Alessandro Geroldi, Serena Patrone, Chiara Gemelli, Corrado Cabona, Guja Astrea, Chiara Fiorillo, Stefano Gustincich, Marina Grandis, Paola Mandich
Frontiers in Neurology.2023;[Epub] CrossRef - Genetic Background of Epilepsy and Antiepileptic Treatments
Kinga Borowicz-Reutt, Julia Czernia, Marlena Krawczyk
International Journal of Molecular Sciences.2023; 24(22): 16280. CrossRef - Zerebellärer Schwindel, was steckt dahinter?
Katharina Feil, Tim W. Rattay, Adedolapo Kamaldeen Adeyemi, Nicolina Goldschagg, Michael Leo Strupp
Laryngo-Rhino-Otologie.2023;[Epub] CrossRef - Coincidental occurance of episodic ataxia and multiple sclerosis: a case report and review of the literature
Melike Batum, Ayşın Kısabay Ak, Güldeniz Çetin, Hamide Betül Gerik Çelebi, Sırrı Çam, Hatice Mavioğlu
International Journal of Neuroscience.2022; 132(7): 656. CrossRef - Vestibular impairments in episodic ataxia type 2
Jae-Hwan Choi, Eun Hye Oh, Seo Young Choi, Hyo Jung Kim, Seon Kyung Lee, Jeong Yoon Choi, Ji-Soo Kim, Kwang-Dong Choi
Journal of Neurology.2022; 269(5): 2687. CrossRef - History of Ataxias and Paraplegias with an Annotation on the First Description of Striatonigral Degeneration
José Berciano, José Gazulla, Jon Infante
The Cerebellum.2022; 21(4): 531. CrossRef - The complexities of CACNA1A in clinical neurogenetics
Marina P. Hommersom, Teije H. van Prooije, Maartje Pennings, Meyke I. Schouten, Hans van Bokhoven, Erik-Jan Kamsteeg, Bart P. C. van de Warrenburg
Journal of Neurology.2022; 269(6): 3094. CrossRef - Genetic paroxysmal neurological disorders featuring episodic ataxia and epilepsy
Elisabetta Amadori, Giuditta Pellino, Lalit Bansal, Serena Mazzone, Rikke S. Møller, Guido Rubboli, Pasquale Striano, Angelo Russo
European Journal of Medical Genetics.2022; 65(4): 104450. CrossRef - Ataxien – Eine aktuelle Übersicht über die
weiter wachsende Anzahl möglicher Diagnosen
Andreas Thieme, Dagmar Timmann
Fortschritte der Neurologie · Psychiatrie.2022; 90(05): 233. CrossRef - Episodic ataxias in children and adolescents: Clinical findings and suggested diagnostic criteria
Filipp Maximilian Filippopulos, Lutz Schnabel, Konstanze Dunker, Ralf Strobl, Doreen Huppert
Frontiers in Neurology.2022;[Epub] CrossRef - Vertical Saccadic Slowing in Episodic Ataxia Type 2
Seoyeon Kim, Seondeuk Kim, Seonkyung Lee, Hyo-Jung Kim
Journal of Clinical Neurology.2022; 18(6): 726. CrossRef - Episodic Vestibular Syndrome with Hyperventilation-Induced Downbeat Nystagmus
Eun Hye Oh, Jin-Hong Shin, Jae Wook Cho, Seo Young Choi, Kwang-Dong Choi, Je-Keun Rhee, Jae-Hwan Choi
The Cerebellum.2021; 20(5): 796. CrossRef - Functional and Biochemical Consequences of Disease Variants in Neurotransmitter Transporters: A Special Emphasis on Folding and Trafficking Deficits
Shreyas Bhat, Ali El-Kasaby, Michael Freissmuth, Sonja Sucic
Pharmacology & Therapeutics.2021; 222: 107785. CrossRef - Therapeutic roles of natural remedies in combating hereditary ataxia: A systematic review
Michael Weng Lok Phang, Sze Yuen Lew, Ivy Chung, William Kiong-Seng Lim, Lee Wei Lim, Kah Hui Wong
Chinese Medicine.2021;[Epub] CrossRef - Episodic psychosis, ataxia, motor neuropathy with pyramidal signs (PAMP syndrome) caused by a novel mutation in ADPRHL2 (AHR3)
Hacer Durmus, Elif Mertoğlu, Heinrich Sticht, Serdar Ceylaner, Işın Baral Kulaksızoğlu, Said Hashemolhosseini, Evren Önay Uçar, Yesim Parman
Neurological Sciences.2021; 42(9): 3871. CrossRef - Pediatric Paroxysmal Exercise-Induced Neurological Symptoms: Clinical Spectrum and Diagnostic Algorithm
Federica Rachele Danti, Federica Invernizzi, Isabella Moroni, Barbara Garavaglia, Nardo Nardocci, Giovanna Zorzi
Frontiers in Neurology.2021;[Epub] CrossRef - Paroxysmal Movement Disorders
Susan Harvey, Mary D. King, Kathleen M. Gorman
Frontiers in Neurology.2021;[Epub] CrossRef - Downbeat nystagmus: a clinical review of diagnosis and management
Tu M. Tran, Michael S. Lee, Collin M. McClelland
Current Opinion in Ophthalmology.2021; 32(6): 504. CrossRef - Ataxien – Eine aktuelle Übersicht über die weiter wachsende Anzahl möglicher Diagnosen
Andreas Thieme, Dagmar Timmann
Neurologie up2date.2021; 04(04): 391. CrossRef - Ataxia episódica: 20 años de retraso diagnóstico
I. Muro García, M.E. Toribio-Díaz, S. Quintas
Neurología.2020; 35(7): 500. CrossRef - The expanding spectrum of movement disorders in genetic epilepsies
Apostolos Papandreou, Federica Rachele Danti, Robert Spaull, Vincenzo Leuzzi, Amy Mctague, Manju A Kurian
Developmental Medicine & Child Neurology.2020; 62(2): 178. CrossRef - Episodic Ataxia Secondary to CEP290 Compound Heterozygous Mutations: A Case Report
Moath Hamed, Aakash Shetty, Tara Dzwiniel, Mark Buller, Lotta Koskinen, Oksana Suchowersky
Movement Disorders Clinical Practice.2020; 7(1): 104. CrossRef - Movement Disorders in Genetic Pediatric Ataxias
Simone Gana, Enza Maria Valente
Movement Disorders Clinical Practice.2020; 7(4): 383. CrossRef - Clinical Spectrum of KCNA1 Mutations: New Insights into Episodic Ataxia and Epilepsy Comorbidity
Kelsey Paulhus, Lauren Ammerman, Edward Glasscock
International Journal of Molecular Sciences.2020; 21(8): 2802. CrossRef - Approach to exaggerated startle reflex: a case of hyperekplexia minor
Haris Hakeem, Ramsha Khurshid, Fowzia Siddiqui, Danish Ejaz Bhatti
BMJ Case Reports.2020; 13(4): e232370. CrossRef - Clinical and Genetic Overview of Paroxysmal Movement Disorders and Episodic Ataxias
Giacomo Garone, Alessandro Capuano, Lorena Travaglini, Federica Graziola, Fabrizia Stregapede, Ginevra Zanni, Federico Vigevano, Enrico Bertini, Francesco Nicita
International Journal of Molecular Sciences.2020; 21(10): 3603. CrossRef - Drosophila Glia: Models for Human Neurodevelopmental and Neurodegenerative Disorders
Taejoon Kim, Bokyeong Song, Im-Soon Lee
International Journal of Molecular Sciences.2020; 21(14): 4859. CrossRef - The Genetic Relationship between Paroxysmal Movement Disorders and Epilepsy
Hyunji Ahn, Tae-Sung Ko
Annals of Child Neurology.2020; 28(3): 76. CrossRef - Episodic ataxia: a 20-year diagnostic delay
I. Muro García, M.E. Toribio-Díaz, S. Quintas
Neurología (English Edition).2020; 35(7): 500. CrossRef - TRPM7 as a Candidate Gene for Vestibular Migraine
Eun Hye Oh, Jin-Hong Shin, Jae Wook Cho, Seo-Young Choi, Kwang-Dong Choi, Jae-Hwan Choi
Frontiers in Neurology.2020;[Epub] CrossRef - Ictal downbeat nystagmus in Ménière disease
Sun-Uk Lee, Hyo-Jung Kim, Jeong-Yoon Choi, Ji-Soo Kim
Neurology.2020; 95(17): e2409. CrossRef - Involvement of the Peripheral Nervous System in Episodic Ataxias
Wojciech Koźmiński, Joanna Pera
Biomedicines.2020; 8(11): 448. CrossRef - Acetazolamide-Responsive Episodic Ataxia Linked to Novel Splice Site Variant in FGF14 Gene
M. Schesny, F. Joncourt, Alexander A. Tarnutzer
The Cerebellum.2019; 18(3): 649. CrossRef - Paroxysmal movement disorders: Recent advances and proposal of a classification system
Xiao-jin Zhang, Zhe-yu Xu, Yun-cheng Wu, Eng-King Tan
Parkinsonism & Related Disorders.2019; 59: 131. CrossRef - Acute cerebellar ataxia: differential diagnosis and clinical approach
José Luiz Pedroso, Thiago Cardoso Vale, Pedro Braga-Neto, Lívia Almeida Dutra, Marcondes Cavalcante França Jr, Hélio A. G. Teive, Orlando G. P. Barsottini
Arquivos de Neuro-Psiquiatria.2019; 77(3): 184. CrossRef - Acute vestibular asymmetry disorder: a new disease entity in acute vestibular syndrome?
Se A. Lee, Eek-Sung Lee, Bo Gyung Kim, Tae-Kyeong Lee, Ki-Bum Sung, Kyurin Hwang, Jong Dae Lee
Acta Oto-Laryngologica.2019; 139(6): 511. CrossRef - Paroxysmal Movement Disorders: Recent Advances
Zheyu Xu, Che-Kang Lim, Louis C. S. Tan, Eng-King Tan
Current Neurology and Neuroscience Reports.2019;[Epub] CrossRef - Paroxysmal movement disorders – practical update on diagnosis and management
Claudio M. De Gusmao, Laura Silveira-Moriyama
Expert Review of Neurotherapeutics.2019; 19(9): 807. CrossRef - Clinical manifestations of episodic ataxia type 5
Miguel González Sánchez, Silvia Izquierdo, Sara Álvarez, Rosa Eva Bautista Alonso, José Berciano, José Gazulla
Neurology: Clinical Practice.2019; 9(6): 503. CrossRef - Pearls & Oy-sters: Paroxysmal dysarthria-ataxia syndrome
Annalisa Gessani, Francesco Cavallieri, Carla Budriesi, Elisabetta Zucchi, Marcella Malagoli, Sara Contardi, Maria Teresa Mascia, Giada Giovannini, Jessica Mandrioli
Neurology.2019; 92(23): e2727. CrossRef - Consensus Paper: Neurophysiological Assessments of Ataxias in Daily Practice
W. Ilg, M. Branscheidt, A. Butala, P. Celnik, L. de Paola, F. B. Horak, L. Schöls, H. A. G. Teive, A. P. Vogel, D. S. Zee, D. Timmann
The Cerebellum.2018; 17(5): 628. CrossRef - The expanding spectrum of paroxysmal movement disorders: update from clinical features to therapeutics
Eavan M. McGovern, Emmanuel Roze, Timothy J. Counihan
Current Opinion in Neurology.2018; 31(4): 491. CrossRef - Benign paroxysmal torticollis of infancy does not lead to neurological sequelae
Annika Danielsson, Britt‐Marie Anderlid, Tommy Stödberg, Kristina Lagerstedt‐Robinson, Eva Klackenberg Arrhenius, Kristina Tedroff
Developmental Medicine & Child Neurology.2018; 60(12): 1251. CrossRef - Epidemiology of inherited cerebellar ataxias and challenges in clinical research
Federica Pilotto, Smita Saxena
Clinical and Translational Neuroscience.2018; 2(2): 2514183X1878525. CrossRef - Ataxia in children: early recognition and clinical evaluation
Piero Pavone, Andrea D. Praticò, Vito Pavone, Riccardo Lubrano, Raffaele Falsaperla, Renata Rizzo, Martino Ruggieri
Italian Journal of Pediatrics.2017;[Epub] CrossRef - Episodic Ataxia Type 1 (K‐channelopathy) Manifesting as Paroxysmal Nonkinesogenic Dyskinesia: Expanding the Phenotype
Kallol K. Set, Debabrata Ghosh, A.H.M. Huq, Aimee F. Luat
Movement Disorders Clinical Practice.2017; 4(5): 784. CrossRef - Genetic Variants Associated with Episodic Ataxia in Korea
Kwang-Dong Choi, Ji-Soo Kim, Hyo-Jung Kim, Ileok Jung, Seong-Hae Jeong, Seung-Han Lee, Dong Uk Kim, Sang-Ho Kim, Seo Young Choi, Jin-Hong Shin, Dae-Seong Kim, Kyung-Pil Park, Hyang-Sook Kim, Jae-Hwan Choi
Scientific Reports.2017;[Epub] CrossRef - Episodic dizziness and vertigo
Štefan Sivák
Neurologie pro praxi.2017; 18(3): 156. CrossRef
- Ataxien – Eine aktuelle Übersicht über die weiter wachsende Anzahl möglicher Diagnosen
Original Article
- The Frequency and Severity of Gastrointestinal Symptoms in Patients with Early Parkinson’s Disease
- Hye-Young Sung, Jeong-Wook Park, Joong-Seok Kim
- J Mov Disord. 2014;7(1):7-12. Published online April 30, 2014
- DOI: https://doi.org/10.14802/jmd.14002
- 17,985 View
- 178 Download
- 56 Citations
-
Abstract
PDF
- Objective: Although gastrointestinal dysfunctions occur in the majority of patients with Parkinson’s disease (PD), they are often unrecognized because many patients remain relatively asymptomatic in the early stage. We investigated the frequency of gastrointestinal symptoms in patients with PD using newly developed gastrointestinal symptom questionnaires.
Methods: Early PD patients with a symptom duration not exceeding 3 years were included in this study. All PD patients were evaluated using a questionnaire, which consisted of three relevant domains: oropharyngoesophageal (10 items); gastric (3 items); and intestinal-anorectal (7 items). The frequency of symptoms was calculated as a proportion with an item score ≥ 2.
Results: Of the 54 patients enrolled, 48 patients (88.9%) responded that bowel symptoms developed before the onset of Parkinsonian motor symptoms, and four patients reported that the onset of two types of symptoms (i.e., bowel and neurological) occurred approximately simultaneously, with only months between them. The frequencies of gastrointestinal symptoms are as follows: speech disturbance (40.7%), drooling (24.1%), sense of getting stuck (31.5%), choking (27.8%), globus pharyngis (16.7%), repetitive deglutition (29.6%), pain during swallowing (5.6%), food regurgitation (3.7%), acid reflux (7.4%), nausea/ vomiting (11.1%), early satiety (16.7%), postprandial fullness (14.8%), epigastric soreness (9.3%), abdominal pain (3.7%), constipation (46.3%), excessive strain during defecation (33.3%), fecal incontinence (7.4%), tenesmus (20.4%), loose stool or diarrhea (3.7%), and difficulty in relaxing anal sphincter (11.1%). Two patients were scored at zero.
Conclusions: Our findings confirm that gastrointestinal dysfunction occurs in early PD in relatively high frequency. -
Citations
Citations to this article as recorded by- Persistent intolerable abdominal pain in patients with Parkinson’s disease
Hiroshi Kataoka, Kazuma Sugie
Clinical Neurology and Neurosurgery.2023; 224: 107558. CrossRef - Striatal Dopaminergic Loss and Dysphagia in Parkinson Disease
Ji Hwan Kim, Jonghu Jeon, Young Lee, Seung Min Kim, Miju Cheon, Jun Yup Kim
Clinical Nuclear Medicine.2023; 48(2): 143. CrossRef - The gut microbiota is an emerging target for improving brain health during ageing
Marcus Boehme, Katherine Elizabeth Guzzetta, Caroline Wasén, Laura Michelle Cox
Gut Microbiome.2023;[Epub] CrossRef - 6-OHDA-Induced Changes in Colonic Segment Contractility in the Rat Model of Parkinson’s Disease
Maria Del Pilar Murillo, Ebba Johansson, Victoria Bryntesson, Patrik Aronsson, Gunnar Tobin, Michael Winder, Thomas Carlsson, Stephen Fink
Gastroenterology Research and Practice.2023; 2023: 1. CrossRef - Efficacy of acupuncture for the treatment of Parkinson’s disease-related constipation (PDC): A randomized controlled trial
Ying-Jia Li, Ian-I Leong, Jing-Qi Fan, Ming-Yue Yan, Xin Liu, Wei-Jing Lu, Yuan-Yuan Chen, Wei-Qiang Tan, Yu-Ting Wang, Li-Xing Zhuang
Frontiers in Neuroscience.2023;[Epub] CrossRef - Considerations for developing a targeted amino acid supplement for people with Parkinson’s disease that promotes health while accounting for pathophysiology and medication interference
Jacob E Earp, Cristina Colon-Semenza, Dara L LoBuono
Nutrition Reviews.2023; 81(8): 1063. CrossRef - Lactobacillus plantarum CCFM405 against Rotenone-Induced Parkinson’s Disease Mice via Regulating Gut Microbiota and Branched-Chain Amino Acids Biosynthesis
Chuanqi Chu, Leilei Yu, Yiwen Li, Hang Guo, Qixiao Zhai, Wei Chen, Fengwei Tian
Nutrients.2023; 15(7): 1737. CrossRef - The longitudinal progression of autonomic dysfunction in Parkinson's disease: A 7-year study
Charlotte B. Stewart, David Ledingham, Victoria K. Foster, Kirstie N. Anderson, Sahana Sathyanarayana, Debra Galley, Nicola Pavese, Jacopo Pasquini
Frontiers in Neurology.2023;[Epub] CrossRef - Association of dysphagia with altered brain glucose metabolism in Parkinson's disease
Ji Yeon Oh, Eui Jin An, Young Lee, Seung Min Kim, Miju Cheon, Jun Yup Kim
CNS Neuroscience & Therapeutics.2023; 29(9): 2498. CrossRef - Differential Findings on Anorectal Manometry in Patients with Parkinson's Disease and Defecatory Dysfunction
Wendy Zhou, George Triadafilopoulos, Brooke Gurland, Houssam Halawi, Laren Becker, Patricia Garcia, Linda Nguyen, Mitchell Miglis, Srikanth Muppidi, Dong‐In Sinn, Safwan Jaradeh, Leila Neshatian
Movement Disorders Clinical Practice.2023; 10(7): 1074. CrossRef - Abdominal pain in Parkinson’s disease
A.A. Pilipovich, O.V. Vorobyova, S.A. Makarov
Russian Journal of Pain.2023; 21(2): 12. CrossRef - Microbiome-Based Therapies in Parkinson’s Disease: Can Tuning the
Microbiota Become a Viable Therapeutic Strategy?
Adejoke Y. Onaolapo, Folusho O. Ojo, Anthony T. Olofinnade, Joshua Falade, Ismail A. Lawal, Olakunle J. Onaolapo
CNS & Neurological Disorders - Drug Targets.2023; 22(9): 1355. CrossRef - Constipation in Parkinson's Disease
Eamonn M. M. Quigley
Seminars in Neurology.2023; 43(04): 562. CrossRef - Neuroimmune Connectomes in the Gut and Their Implications in Parkinson’s Disease
Beatriz Thomasi, Luisa Valdetaro, Brian Gulbransen, Ana Lúcia Tavares-Gomes
Molecular Neurobiology.2023;[Epub] CrossRef - Related Effects of Methamphetamine on the Intestinal Barrier via Cytokines, and Potential Mechanisms by Which Methamphetamine May Occur on the Brain-Gut Axis
Yuansen Li, Deshenyue Kong, Ke Bi, Huayou Luo
Frontiers in Medicine.2022;[Epub] CrossRef - Alpha-synuclein and tau are abundantly expressed in the ENS of the human appendix and monkey cecum
Alexandra D. Zinnen, Jonathan Vichich, Jeanette M. Metzger, Julia C. Gambardella, Viktoriya Bondarenko, Heather A. Simmons, Marina E. Emborg, Stephan N. Witt
PLOS ONE.2022; 17(6): e0269190. CrossRef - Management of dysphagia and gastroparesis in Parkinson’s disease in real-world clinical practice – Balancing pharmacological and non-pharmacological approaches
Roongroj Bhidayasiri, Warongporn Phuenpathom, Ai Huey Tan, Valentina Leta, Saisamorn Phumphid, K. Ray Chaudhuri, Pramod Kumar Pal
Frontiers in Aging Neuroscience.2022;[Epub] CrossRef - Mechanisms of development of constipation in Parkinson’s disease and therapeutic approaches
E.A. Katunina, N.N. Shipilova, D.A. Katunin
Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova.2022; 122(8): 21. CrossRef - Intestinal Permeability, Dysbiosis, Inflammation and Enteric Glia Cells: The Intestinal Etiology of Parkinson’s Disease
Huijia Yang, Song Li, Weidong Le
Aging and disease.2022; 13(5): 1381. CrossRef - The interplay between the gut-brain axis and the microbiome: A perspective on psychiatric and neurodegenerative disorders
Yasir Bashir, Asad U. Khan
Frontiers in Neuroscience.2022;[Epub] CrossRef - Clinical features and relative factors of constipation in a cohort of Chinese patients with Parkinson's disease
Bai-Hua Sun, Tao Wang, Nian-Ying Li, Qiong Wu, Jin Qiao
World Journal of Gastrointestinal Pharmacology and Therapeutics.2021; 12(1): 21. CrossRef - Characterization of Gastrointestinal Symptom Type and Severity in Parkinson's Disease: A Case–Control Study in an Australian Cohort
Jade E. Kenna, Megan C. Bakeberg, Anastazja M. Gorecki, Alfred Chin Yen Tay, Samantha Winter, Frank L. Mastaglia, Ryan S. Anderton
Movement Disorders Clinical Practice.2021; 8(2): 245. CrossRef - Granisetron, a selective 5-HT3 antagonist, reduces L-3,4-dihydroxyphenylalanine-induced abnormal involuntary movements in the 6-hydroxydopamine-lesioned rat
Cynthia Kwan, Imane Frouni, Dominique Bédard, Adjia Hamadjida, Philippe Huot
Behavioural Pharmacology.2021; 32(1): 43. CrossRef - Deglutition Impairment during Dual Task in Parkinson Disease Is Associated with Cognitive Status
Luciana Grolli Ardenghi, Alana Verza Signorini, Gerson Schulz Maahs, Fabio Selaimen, Konrado Massing Deutsch, Silvia Dornelles, Carlos Roberto de Mello Rieder
International Archives of Otorhinolaryngology.2021; 25(01): e41. CrossRef - Spectrum of Non-Motor Symptoms in Parkinson's Disease
Maithrayie Kumaresan, Safeera Khan
Cureus.2021;[Epub] CrossRef - Onset of Skin, Gut, and Genitourinary Prodromal Parkinson's Disease: A Study of 1.5 Million Veterans
Gregory D. Scott, Miranda M. Lim, Matthew G. Drake, Randy Woltjer, Joseph F. Quinn
Movement Disorders.2021; 36(9): 2094. CrossRef - The Gastrointestinal Dysfunction Scale for Parkinson's Disease
Marta Camacho, Julia C. Greenland, Caroline H. Williams‐Gray
Movement Disorders.2021; 36(10): 2358. CrossRef - The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders
Katarzyna Socała, Urszula Doboszewska, Aleksandra Szopa, Anna Serefko, Marcin Włodarczyk, Anna Zielińska, Ewa Poleszak, Jakub Fichna, Piotr Wlaź
Pharmacological Research.2021; 172: 105840. CrossRef - Neuro-Immunity and Gut Dysbiosis Drive Parkinson’s Disease-Induced Pain
Katiane Roversi, Natalia Callai-Silva, Karine Roversi, May Griffith, Christos Boutopoulos, Rui Daniel Prediger, Sébastien Talbot
Frontiers in Immunology.2021;[Epub] CrossRef - Autonomic dysfunction in Parkinson’s disease: Implications for pathophysiology, diagnosis, and treatment
Zhichun Chen, Guanglu Li, Jun Liu
Neurobiology of Disease.2020; 134: 104700. CrossRef - Double‐Blind, Randomized, Placebo‐Controlled Trial of DA‐9701 in Parkinson's Disease: PASS‐GI Study
Ji‐Hyun Choi, Jee‐Young Lee, Jin Whan Cho, Seong‐Beom Koh, Young Soon Yang, Dalla Yoo, Cheol‐Min Shin, Hee Tae Kim
Movement Disorders.2020; 35(11): 1966. CrossRef - Parkinson disease and the gut: new insights into pathogenesis and clinical relevance
R. Alberto Travagli, Kirsteen N. Browning, Michael Camilleri
Nature Reviews Gastroenterology & Hepatology.2020; 17(11): 673. CrossRef - Expanding the brain researcher's toolkit
Viviana Gradinaru
Science.2020; 369(6504): 637. CrossRef - Excessive buccal saliva in patients with Parkinson’s disease of the French COPARK cohort
Olivier Rascol, Laurence Negre-Pages, Philippe Damier, Arnaud Delval, Pascal Derkinderen, Alain Destée, Margherita Fabbri, Wassilios G. Meissner, Amine Rachdi, François Tison, Santiago Perez-Lloret
Journal of Neural Transmission.2020; 127(12): 1607. CrossRef - Struktur und Efferenzen der Substantia nigra pars compacta beim idiopathischen Parkinson-Syndrom
Peter Urban, Bjorn Falkenburger, Wolfgang H. Jost, Gerhard Ransmayr, Peter Riederer, Christian Winkler
Fortschritte der Neurologie · Psychiatrie.2020; 88(09): 591. CrossRef - Parkinson’s disease: Are gut microbes involved?
Yogesh Bhattarai, Purna C. Kashyap
American Journal of Physiology-Gastrointestinal and Liver Physiology.2020; 319(5): G529. CrossRef - Does Bilateral Deep Brain Stimulation of the Subthalamic Nucleus Modify Ano-Rectal Motility in Parkinson’s Disease? Results of a Randomized Cross-Over Study
Guillaume Gourcerol, David Maltete, Nathalie Chastan, Marie Laure Welter, Anne Marie Leroi, Stéphane Derrey
Neuromodulation: Technology at the Neural Interface.2019; 22(4): 478. CrossRef - Probiotics for Parkinson’s Disease
Gazerani
International Journal of Molecular Sciences.2019; 20(17): 4121. CrossRef - Colon dysregulation in methamphetamine self-administering HIV-1 transgenic rats
Amanda L. Persons, Brinda D. Bradaric, Hemraj B. Dodiya, Michael Ohene-Nyako, Christopher B. Forsyth, Ali Keshavarzian, Maliha Shaikh, T. Celeste Napier, Shilpa J. Buch
PLOS ONE.2018; 13(1): e0190078. CrossRef - Induction of alpha-synuclein pathology in the enteric nervous system of the rat and non-human primate results in gastrointestinal dysmotility and transient CNS pathology
Fredric P. Manfredsson, Kelvin C. Luk, Matthew J. Benskey, Aysegul Gezer, Joanna Garcia, Nathan C. Kuhn, Ivette M. Sandoval, Joseph R. Patterson, Alana O'Mara, Reid Yonkers, Jeffrey H. Kordower
Neurobiology of Disease.2018; 112: 106. CrossRef - Dysbiosis of gut microbiota and microbial metabolites in Parkinson’s Disease
Meng-Fei Sun, Yan-Qin Shen
Ageing Research Reviews.2018; 45: 53. CrossRef - Parkinson’s Disease and Current Treatments for Its Gastrointestinal Neurogastromotility Effects
Chethan Ramprasad, Jane Yellowlees Douglas, Baharak Moshiree
Current Treatment Options in Gastroenterology.2018; 16(4): 489. CrossRef - Transdermal rotigotine patch in Parkinson’s disease with a history of intestinal operation
Takashi Ogawa, Genko Oyama, Nobutaka Hattori
BMJ Case Reports.2018; : bcr-2017-223722. CrossRef - α-Synuclein in the colon and premotor markers of Parkinson disease in neurologically normal subjects
Joong-Seok Kim, In-Seok Park, Hyung-Eun Park, Su-Young Kim, Jung A Yun, Chan Kwon Jung, Hye-Young Sung, Jin-Kwon Lee, Won-Kyung Kang
Neurological Sciences.2017; 38(1): 171. CrossRef - The Threshold Theory for Parkinson's Disease
Simone Engelender, Ole Isacson
Trends in Neurosciences.2017; 40(1): 4. CrossRef - Constipation in parkinson's disease: Subjective symptoms, objective markers, and new perspectives
Karoline Knudsen, Klaus Krogh, Karen Østergaard, Per Borghammer
Movement Disorders.2017; 32(1): 94. CrossRef - Is Levodopa Pharmacokinetics in Patients with Parkinson’s Disease Depending on Gastric Emptying?
Maria Nord, Anita Kullman, Ulf Hannestad, Nil Dizdar
Advances in Parkinson's Disease.2017; 06(01): 1. CrossRef - Validation of the Korean Version of the Scale for Outcomes in Parkinson’s Disease-Autonomic
Ji-Young Kim, In-Uk Song, Seong-Beom Koh, Tae-Beom Ahn, Sang Jin Kim, Sang-Myung Cheon, Jin Whan Cho, Yun Joong Kim, Hyeo-Il Ma, Mee-Young Park, Jong Sam Baik, Phil Hyu Lee, Sun Ju Chung, Jong-Min Kim, Han-Joon Kim, Young-Hee Sung, Do Young Kwon, Jae-Hyeo
Journal of Movement Disorders.2017; 10(1): 29. CrossRef - Gastroesophageal reflux disease with proton pump inhibitor use is associated with an increased risk of osteoporosis: a nationwide population-based analysis
C.-H. Chen, C.-L. Lin, C.-H. Kao
Osteoporosis International.2016; 27(6): 2117. CrossRef - Parkinson Disease-Mediated Gastrointestinal Disorders and Rational for Combinatorial Therapies
Syed Ali, Ning Yin, Arkam Rehman, Verline Justilien
Medical Sciences.2016; 4(1): 1. CrossRef - Intestinal dysfunction in Parkinson's disease: Lessons learned from translational studies and experimental models
C. Pellegrini, R. Colucci, L. Antonioli, E. Barocelli, V. Ballabeni, N. Bernardini, C. Blandizzi, W. J. de Jonge, M. Fornai
Neurogastroenterology & Motility.2016; 28(12): 1781. CrossRef - Gut dysfunction in Parkinson's disease
Adreesh Mukherjee, Atanu Biswas, Shyamal Kumar Das
World Journal of Gastroenterology.2016; 22(25): 5742. CrossRef - Inflammation is genetically implicated in Parkinson’s disease
N. Dzamko, C.L Geczy, G.M Halliday
Neuroscience.2015; 302: 89. CrossRef - Alteration of enteric monoamines with monoamine receptors and colonic dysmotility in 6-OHDA-induced Parkinson’s disease rats
Xiaoli Zhang, Yun Li, Chenzhe Liu, Ruifang Fan, Ping Wang, Lifei Zheng, Feng Hong, Xiaoyan Feng, Yue Zhang, Lisheng Li, Jinxia Zhu
Translational Research.2015;[Epub] CrossRef - The treatment of gastroparesis, constipation and small intestinal bacterial overgrowth syndrome in patients with Parkinson’s disease
Jose L Barboza, Michael S Okun, Baharak Moshiree
Expert Opinion on Pharmacotherapy.2015; 16(16): 2449. CrossRef - Gastrointestinal Dysfunctions in Parkinson’s Disease
Joong-Seok Kim, Hey Young Sung
Journal of the Korean Neurological Association.2015; 33(4): 247. CrossRef
- Persistent intolerable abdominal pain in patients with Parkinson’s disease
Review Article
- COVID-19: An Early Review of Its Global Impact and Considerations for Parkinson’s Disease Patient Care
- Roongroj Bhidayasiri, Sasivimol Virameteekul, Jong-Min Kim, Pramod Kr. Pal, Sun-Ju Chung
- J Mov Disord. 2020;13(2):105-114. Published online April 30, 2020
- DOI: https://doi.org/10.14802/jmd.20042
- 19,833 View
- 755 Download
- 52 Citations
-
Abstract
PDF
- While many infectious disorders are unknown to most neurologists, COVID-19 is very different. It has impacted neurologists and other health care workers, not only in our professional lives but also through the fear and panic within our own families, colleagues, patients and their families, and even in the wider public. COVID-19 affects all sorts of individuals, but the elderly with underlying chronic conditions are particularly at risk of severe disease, or even death. Parkinson’s disease (PD) shares a common profile as an age-dependent degenerative disorder, frequently associated with comorbidities, particularly cardiovascular diseases, so PD patients will almost certainly fall into the high-risk group. Therefore, the aim of this review is to explore the risk of COVID-19 in PD based on the susceptibility to severe disease, its impact on PD disease severity, potential long-term sequelae, and difficulties of PD management during this outbreak, where neurologists face various challenges on how we can maintain effective care for PD patients without exposing them, or ourselves, to the risk of infection. It is less than six months since the identification of the original COVID-19 case on New Year’s Eve 2019, so it is still too early to fully understand the natural history of COVID-19 and the evidence on COVID-19-related PD is scant. Though the possibilities presented are speculative, they are theory-based, and supported by prior evidence from other neurotrophic viruses closely related to SARS-CoV-2. Neurologists should be on high alert and vigilant for potential acute and chronic complications when encountering PD patients who are suspected of having COVID-19.
-
Citations
Citations to this article as recorded by- Calidad de vida de las personas con enfermedad de Parkinson durante el confinamiento por la pandemia por covid-19
A.M. Fernández-Elgueta, H.F. Retamal-Matus, C. Núñez-Espinosa, P. Barria Aburto
Rehabilitación.2024; 58(1): 100821. CrossRef - COVID-19 and Parkinson’s disease: a systematic review and meta-analysis
Maryam Afraie, Ghobad Moradi, Pardis Mohammadzedeh, Mobin Azami, Sevda Riyahifar, Yousef Moradi
Acta Neurologica Belgica.2023; 123(4): 1209. CrossRef - Survey on the Impact of the COVID-19 Pandemic on Patients with Parkinson’s Disease and Their Caregivers in Japan
Nobutaka Hattori, Yoshiko Okada, Yayoi Kawata, Yoshihiko Furusawa, Takumi Imai, Hisako Yoshida, Mihoko Ota, Masaki Arai, Ayumi Shintani, Jovelle Fernandez
Patient Preference and Adherence.2023; Volume 17: 1221. CrossRef - COVID-19 and neurological disorders: what might connect Parkinson’s disease to SARS-CoV-2 infection
Salvatore Iacono, Giuseppe Schirò, Chiara Davì, Sergio Mastrilli, Michelle Abbott, Fabrizio Guajana, Valentina Arnao, Paolo Aridon, Paolo Ragonese, Cesare Gagliardo, Claudia Colomba, Nicola Scichilone, Marco D’Amelio
Frontiers in Neurology.2023;[Epub] CrossRef - Worsening of Parkinson’s Disease After Termination of COVID-19 Quarantine Cannot Be Reversed Despite Resumption of Physiotherapy
Christian Ineichen, Heide Vogel-Baumann, Matthias Sitzler, Günther Deuschl, Christian R. Baumann
Journal of Parkinson's Disease.2023; 13(5): 845. CrossRef - The Impact of COVID-19 on Parkinson’s Disease: A Case-Controlled Registry and Questionnaire Study on Clinical Markers and Patients’ Perceptions
Gustav Cedergren Weber, Jonathan Timpka, Filip Bergquist, David Bäckström, Nil Dizdar, Karin Gunnarsson, Dag Nyholm, Per Svenningsson, Per Odin, Gessica Sala
Acta Neurologica Scandinavica.2023; 2023: 1. CrossRef - Remote Assessment of Parkinson’s Disease Patients Amidst the COVID-19 Lockdown in Mexico
Rodrigo León-García, Emmanuel Ortega-Robles, Oscar Arias-Carrión
Brain Sciences.2023; 13(7): 1114. CrossRef - Social and economic development impact of elderly health care products based on design ethics
Na Qi, Xun Zhang, Muhammad Attique Khan, Gaurav Dhiman, Sathishkumar VE
Intelligent Data Analysis.2023; 27: 137. CrossRef - The effects of an individualized smartphone-based exercise program on self-defined motor tasks in Parkinson’s disease: a long-term feasibility study
Lisa Lützow, Isabelle Teckenburg, Veronika Koch, Franz Marxreiter, Jelena Jukic, Sabine Stallforth, Martin Regensburger, Jürgen Winkler, Jochen Klucken, Heiko Gaßner
Journal of Patient-Reported Outcomes.2023;[Epub] CrossRef - Doctor Hope; Calming and Comforting Loneliness in Parkinson’s Disease
Sasivimol Virameteekul, Roongroj Bhidayasiri
Clinical Parkinsonism & Related Disorders.2022; 6: 100131. CrossRef - Neurological toll of COVID-19
Shivam Bhola, Jhillika Trisal, Vikram Thakur, Parneet Kaur, Saurabh Kulshrestha, Shashi Kant Bhatia, Pradeep Kumar
Neurological Sciences.2022; 43(4): 2171. CrossRef - Resilience and Trauma among Patients with Parkinson’s Disease during the COVID-19 Pandemic
Roberto Erro, Sofia Cuoco, Emanuele Nigro, Raffaele Ragone, Paolo Barone
Journal of Movement Disorders.2022; 15(1): 77. CrossRef - Implication of Covid-19 on Neurological Complications with Specific Emphasis
on Alzheimer’s and Parkinson’s Disease
Ankita Sood, Ravi Goyal, Harshdeep Singh, Tapan Behl, Sandeep Arora, Balraj Saini, Rajwinder Kaur
CNS & Neurological Disorders - Drug Targets.2022; 21(3): 235. CrossRef - The use of amantadine in the prevention of progression and treatment of COVID-19 symptoms in patients infected with the SARS-CoV-2 virus (COV-PREVENT): Study rationale and design
Konrad Rejdak, Piotr Fiedor, Robert Bonek, Aleksander Goch, Agnieszka Gala-Błądzińska, Waldemar Chełstowski, Jacek Łukasiak, Sławomir Kiciak, Piotr Dąbrowski, Mateusz Dec, Zbigniew J. Król, Ewa Papuć, Adriana Zasybska, Agnieszka Segiet, Paweł Grieb
Contemporary Clinical Trials.2022; 116: 106755. CrossRef - Neuropathological Aspects of SARS-CoV-2 Infection: Significance for Both Alzheimer’s and Parkinson’s Disease
Jaime Silva, Felipe Patricio, Aleidy Patricio-Martínez, Gerardo Santos-López, Lilia Cedillo, Yousef Tizabi, Ilhuicamina Daniel Limón
Frontiers in Neuroscience.2022;[Epub] CrossRef - Online dance classes during the Covid-19 pandemic: new challenges and teaching strategies for the ‘Dance & Parkinson’s at home’ project
Marcela Dos Santos Delabary, Isadora Loch Sbeghen, Mariana Wolffenbuttel, Djefri Ramon Pereira, Aline Nogueira Haas
Research in Dance Education.2022; : 1. CrossRef - Impact of the COVID-19 Pandemic on Chronic Neurological Disorders: Focus on Patients with Dementia
Maria Antonietta Barbieri, Gianluca Bagnato, Carmelo Ioppolo, Antonio Giovanni Versace, Natasha Irrera
CNS & Neurological Disorders - Drug Targets.2022; 21(10): 1017. CrossRef - Factors Related to Experiencing Pain in Patients Affected by Chronic Inflammatory Rheumatic Disease During the COVID-19 Pandemic
Tfarah El Joumani, Hanan Rkain, Fatima Zahrae Taik, Kenza Hassouni, Redouane Abouqal, Sara Bahloul, Nada Alami, Latifa Tahiri, Najia Hajjaj-Hassouni, Fadoua Allali
The Open Pain Journal.2022;[Epub] CrossRef - A “new” role of amantadines in COVID-19 in patients with Parkinson’s disease: results of own comparative study
Z. A. Zalyalova, S. E. Munasipova, D. M. Khasanova, G. R. Ilyina, Z. G. Khayatova, N. I. Bagdanova
Neurology, Neuropsychiatry, Psychosomatics.2022; 14(6): 40. CrossRef - Attitudes toward telemedicine of patients with Parkinson’s disease during the COVID‐19 pandemic
Kanako Kurihara, Koichi Nagaki, Kotoe Inoue, Sumiko Yamamoto, Takayasu Mishima, Shinsuke Fujioka, Shinji Ouma, Yoshio Tsuboi
Neurology and Clinical Neuroscience.2021; 9(1): 77. CrossRef - Risk of Hospitalization and Death for COVID‐19 in People with Parkinson's Disease or Parkinsonism
Luca Vignatelli, Corrado Zenesini, Laura M.B. Belotti, Elisa Baldin, Giuseppe Bonavina, Giovanna Calandra‐Buonaura, Pietro Cortelli, Carlo Descovich, Giovanni Fabbri, Giulia Giannini, Maria Guarino, Roberta Pantieri, Giuseppe Samoggia, Cesa Scaglione, Sus
Movement Disorders.2021; 36(1): 1. CrossRef - Impact of COVID-19 in the Mental Health in Elderly: Psychological and Biological Updates
Roberta Eduarda Grolli, Maiqueli Eduarda Dama Mingoti, Amanda Gollo Bertollo, Adriana Remião Luzardo, João Quevedo, Gislaine Zilli Réus, Zuleide Maria Ignácio
Molecular Neurobiology.2021; 58(5): 1905. CrossRef - COVID-19: Implications for Sudden Death in Parkinson’s Disease
Ana Claudia Fiorini, Marcelo Cunio Machado Fonseca, Carla Alessandra Scorza, Josef Finsterer, Antônio Márcio Rodrigues, Antônio-Carlos Guimarães de Almeida, Fulvio Alexandre Scorza
Journal of Movement Disorders.2021; 14(1): 78. CrossRef - Impact and Challenges of the COVID-19 Pandemic on Patients Requiring Botulinum Toxin A Treatment
Azalea Tenerife Pajo, Adrian Isidoro Espiritu, Roland Dominic Go Jamora
Journal of Movement Disorders.2021; 14(1): 29. CrossRef - COVID-19 in age-related neurodegenerative diseases: is there a role for vitamin D3 as a possible therapeutic strategy?
Milena de Barros Viana, Bárbara dos Anjos Rosário, Maria de Fátima Santana de Nazaré, Débora Estadella, Daniel Araki Ribeiro, Glauce Socorro de Barros Viana
Reviews in the Neurosciences.2021; 32(2): 235. CrossRef - How COVID-19 will boost remote exercise-based treatment in Parkinson’s disease: a narrative review
Agnes Langer, Lucia Gassner, Anna Flotz, Sebastian Hasenauer, Jakob Gruber, Laurenz Wizany, Rochus Pokan, Walter Maetzler, Heidemarie Zach
npj Parkinson's Disease.2021;[Epub] CrossRef - Neurological Manifestation of SARS-CoV-2 Induced Inflammation and Possible Therapeutic Strategies Against COVID-19
Dipak Kumar, Sadaf Jahan, Andleeb Khan, Arif Jamal Siddiqui, Neeru Singh Redhu, Wahajuddin, Johra Khan, Saeed Banwas, Bader Alshehri, Mohammed Alaidarous
Molecular Neurobiology.2021; 58(7): 3417. CrossRef - Auswirkungen der COVID-19 Pandemie auf die medizinische Versorgung von Patienten mit angeborenen Blutungsneigungen
Martin Olivieri, Susan Halimeh, Cornelia Wermes, Wolf Hassenpflug, Katharina Holstein, Sylvia von Mackensen
Das Gesundheitswesen.2021; 83(04): 282. CrossRef - Parkinsonism hyperpyraexia syndrome in Parkinson's disease patients undergoing deep brain stimulation: An indirect consequence of COVID-19 lockdowns
Onanong Phokaewvarangkul, Sasivimol Virameteekul, Roongroj Bhidayasiri
Parkinsonism & Related Disorders.2021; 87: 39. CrossRef - Clinical Profiles and Mortality of COVID‐19 Inpatients with Parkinson's Disease in Germany
Raphael Scherbaum, Eun Hae Kwon, Daniel Richter, Dirk Bartig, Ralf Gold, Christos Krogias, Lars Tönges
Movement Disorders.2021; 36(5): 1049. CrossRef - Chronic pain experience and health inequities during the COVID-19 pandemic in Canada: qualitative findings from the chronic pain & COVID-19 pan-Canadian study
Lise Dassieu, M. Gabrielle Pagé, Anaïs Lacasse, Maude Laflamme, Vickie Perron, Audrée Janelle-Montcalm, Maria Hudspith, Gregg Moor, Kathryn Sutton, James M Thompson, Manon Choinière
International Journal for Equity in Health.2021;[Epub] CrossRef - The Influence of Coronavirus Disease-2019 (COVID-19) On Parkinson’s Disease: An Updated Systematic Review
Vikash Jaiswal, Danah Alquraish, Zouina Sarfraz, Azza Sarfraz, Shavy Nagpal, Prakriti Singh Shrestha, Dattatreya Mukherjee, Prathima Guntipalli, Diana F. Sánchez Velazco, Arushee Bhatnagar, Saloni Savani, Elmjedina Halilaj, Samir Ruxmohan, Wilson Cueva
Journal of Primary Care & Community Health.2021; 12: 215013272110397. CrossRef - Personalized Medicine in Parkinson’s Disease: New Options for Advanced Treatments
Takayasu Mishima, Shinsuke Fujioka, Takashi Morishita, Tooru Inoue, Yoshio Tsuboi
Journal of Personalized Medicine.2021; 11(7): 650. CrossRef - Parkinson's disease patients may have higher rates of Covid-19 mortality in Iran
Mehri Salari, Masoud Etemadifar, Farzad Ashrafi, Davood Ommi, Zahra Aminzade, Sepand Tehrani Fateh
Parkinsonism & Related Disorders.2021; 89: 90. CrossRef - COVID-19 social distancing: negative effects on people with Parkinson disease and their associations with confidence for self-management
Galit Yogev-Seligmann, Michal Kafri
BMC Neurology.2021;[Epub] CrossRef - Covid-19 in Parkinson's Disease treated by drugs or brain stimulation
M. Salari, M. Etemadifar, A. Zali, Z. Aminzade, I. Navalpotro-Gomez, S. Tehrani Fateh
Neurología.2021;[Epub] CrossRef - Management of Parkinson’s Disease in the COVID-19 Pandemic and Future Perspectives in the Era of Vaccination
Yue Hui Lau, Keng Ming Lau, Norlinah Mohamed Ibrahim
Journal of Movement Disorders.2021; 14(3): 177. CrossRef - Parkinson’s Disease and the COVID-19 Pandemic: A Review Article on the Association between SARS-CoV-2 and α-Synucleinopathy
Smriti Sinha, Swati Mittal, Rupali Roy
Journal of Movement Disorders.2021; 14(3): 184. CrossRef - Impact of COVID‐19 on Patient Care, Training, and Research in Movement Disorders in MDS‐AOS Region
Shweta Prasad, Hrishikesh Kumar, Roongroj Bhidayasiri, Pramod Kumar Pal
Movement Disorders.2021; 36(11): 2457. CrossRef - Secondary Impact of COVID-19 Pandemic on People with Parkinson’s Disease—Results of a Polish Online Survey
Karolina Krzysztoń, Beata Mielańczuk-Lubecka, Jakub Stolarski, Anna Poznańska, Katarzyna Kępczyńska, Agata Zdrowowicz, Izabela Domitrz, Jan Kochanowski
Brain Sciences.2021; 12(1): 26. CrossRef - Neurological consultations and diagnoses in a large, dedicated COVID-19 university hospital
Adalberto STUDART-NETO, Bruno Fukelmann GUEDES, Raphael de Luca e TUMA, Antonio Edvan CAMELO FILHO, Gabriel Taricani KUBOTA, Bruno Diógenes IEPSEN, Gabriela Pantaleão MOREIRA, Júlia Chartouni RODRIGUES, Maíra Medeiros Honorato FERRARI, Rafael Bernhart CAR
Arquivos de Neuro-Psiquiatria.2020; 78(8): 494. CrossRef - Potential impact and challenges associated with Parkinson’s disease patient care amidst the COVID-19 global pandemic
Ali Elbeddini, Anthony To, Yasamin Tayefehchamani, Cindy Wen
Journal of Clinical Movement Disorders.2020;[Epub] CrossRef - COVID-19 and possible links with Parkinson’s disease and parkinsonism: from bench to bedside
David Sulzer, Angelo Antonini, Valentina Leta, Anna Nordvig, Richard J. Smeyne, James E. Goldman, Osama Al-Dalahmah, Luigi Zecca, Alessandro Sette, Luigi Bubacco, Olimpia Meucci, Elena Moro, Ashley S. Harms, Yaqian Xu, Stanley Fahn, K. Ray Chaudhuri
npj Parkinson's Disease.2020;[Epub] CrossRef - Impact of Prolonged Lockdown due to COVID-19 in Patients with Parkinson's Disease
Shweta Prasad, VikramVenkappayya Holla, Koti Neeraja, BharathKumar Surisetti, Nitish Kamble, Ravi Yadav, PramodKumar Pal
Neurology India.2020; 68(4): 792. CrossRef - The Effect of the COVID-19 Pandemic on People with Parkinson’s Disease
Ethan G. Brown, Lana M. Chahine, Samuel M. Goldman, Monica Korell, Emerald Mann, Daniel R. Kinel, Vanessa Arnedo, Kenneth L. Marek, Caroline M. Tanner
Journal of Parkinson's Disease.2020; 10(4): 1365. CrossRef - Impact of COVID‐19 pandemic on mental health of patients with inherited bleeding disorders in Germany
Sylvia von Mackensen, Susan Halimeh, Manuela Siebert, Cornelia Wermes, Wolf Hassenpflug, Katharina Holstein, Martin Olivieri
Haemophilia.2020;[Epub] CrossRef - Impact of Coronavirus Disease 2019 Pandemic on Parkinson's Disease: A Cross‐Sectional Survey of 568 Spanish Patients
Diego Santos‐García, Mila Oreiro, Patricia Pérez, Gemma Fanjul, Jose Manuel Paz González, María José Feal Painceiras, Carlos Cores Bartolomé, Lorena Valdés Aymerich, Carlos García Sancho, Maria del Mar Castellanos Rodrigo
Movement Disorders.2020; 35(10): 1712. CrossRef - The Impact of COVID‐19 on Access to Parkinson's Disease Medication
Julia Ling‐Yu Cheong, Zhao Hang Keith Goh, Connie Marras, Caroline M. Tanner, Meike Kasten, Alastair J. Noyce
Movement Disorders.2020; 35(12): 2129. CrossRef - Deep Brain Stimulation Battery Exhaustion during the COVID-19 Pandemic: Crisis within a Crisis
Vikram Venkappayya Holla, Koti Neeraja, Bharath Kumar Surisetti, Shweta Prasad, Nitish Kamble, Dwarakanath Srinivas, Ravi Yadav, Pramod Kumar Pal
Journal of Movement Disorders.2020; 13(3): 218. CrossRef - Clinical Characteristics of Coronavirus Disease 2019 (COVID-19) among Patients at a Movement Disorders Center
Joy Antonelle de Marcaida, Jeffrey Lahrmann, Duarte Machado, Lawrence Bluth, Michelle Dagostine, Maria Moro-de Casillas, Elena Bortan, Sulada Kanchana, Mark Alberts
Geriatrics.2020; 5(3): 54. CrossRef - Update on Neurological Manifestations of SARS-CoV-2
Hisham Valiuddin, Almir Kalajdzic, James Rosati, Kevin Boehm, Dominique Hill
Western Journal of Emergency Medicine.2020;[Epub] CrossRef - Effects of COVID-19 Lockdown on Movement Disorders Patients With Deep Brain Stimulation: A Multicenter Survey
Carla Piano, Francesco Bove, Tommaso Tufo, Isabella Imbimbo, Danilo Genovese, Alessandro Stefani, Massimo Marano, Antonella Peppe, Livia Brusa, Rocco Cerroni, Francesco Motolese, Enrico Di Stasio, Marianna Mazza, Antonio Daniele, Alessandro Olivi, Paolo C
Frontiers in Neurology.2020;[Epub] CrossRef
- Calidad de vida de las personas con enfermedad de Parkinson durante el confinamiento por la pandemia por covid-19
Original Article
- Orthostatic and Supine Blood Pressures Are Associated with White Matter Hyperintensities in Parkinson Disease
- Yoon-Sang Oh, Joong-Seok Kim, Kwang-Soo Lee
- J Mov Disord. 2013;6(2):23-27. Published online October 30, 2013
- DOI: https://doi.org/10.14802/jmd.13006
- 15,068 View
- 98 Download
- 49 Citations
-
Abstract
PDF
Background and Purpose: Several reports on the elderly population have suggested that orthostatic hypotension is associated with white matter hyperintensities (WMH); however, little information is available on patients with Parkinson’s disease (PD).
Methods: We analyzed the association blood pressure profiles during tilt table testing with WMH scores in 117 patients with PD. WMH were rated using the semiquantitative visual rating system proposed by Scheltens et al.
Results: The presence of orthostatic hypotension was associated with increasing tendency of WMH score and the blood pressure changes during tilting and supine blood pressure were positively correlated with increasing WMH score.
Conclusions: This finding indicates that hemodynamic changes associated with orthostatic hypotension may be associated with white matter changes in patients with PD.
-
Citations
Citations to this article as recorded by- Association Between Gait and Dysautonomia in Patients With De Novo Parkinson’s Disease: Forward Gait Versus Backward Gait
Seon-Min Lee, Mina Lee, Eun Ji Lee, Rae On Kim, Yongduk Kim, Kyum-Yil Kwon
Journal of Movement Disorders.2023; 16(1): 59. CrossRef - Association Between Orthostatic Hypotension and Dementia in Patients With Parkinson Disease and Multiple System Atrophy
Iñigo Ruiz Barrio, Yasuo Miki, Zane T. Jaunmuktane, Thomas Warner, Eduardo De Pablo-Fernandez
Neurology.2023; 100(10): e998. CrossRef - Central retinal microvasculature damage is associated with orthostatic hypotension in Parkinson’s disease
Jong Hyeon Ahn, Min Chae Kang, Dongyoung Lee, Jin Whan Cho, Kyung-Ah Park, Jinyoung Youn
npj Parkinson's Disease.2023;[Epub] CrossRef - Interventions for orthostatic hypotension in Parkinson's disease: a systematic review and network meta-analysis
Kunshan Li, Luyi Wu, Xuejun Cui, Wei Zhang, Jun Ji, Yiwen Wu, Zhaoqin Wang, Huirong Liu, Huangan Wu, Lu Zhu
Cochrane Database of Systematic Reviews.2023;[Epub] CrossRef - Autonomic control of heart and vessels in patients with very early stage of Parkinson disease
J Oleksakova, M Javorka, B Czippelova, N Mazgutova, M Grofik, L Babalova, P Skacik, E Kurca
Physiological Measurement.2023; 44(5): 054002. CrossRef - The mechanism of impaired delayed recall verbal memory function in Parkinson's disease with orthostatic hypotension: a multiple imaging study
Xiaofan Xue, Anqi Huang, Jingrong Zeng, Haixia Song, Yingqi Xing, Piu Chan, Erhe Xu, Lichun Zhou
Frontiers in Neurology.2023;[Epub] CrossRef - Cognitive Deficits in Parkinson's Disease Are Associated with Neuronal Dysfunction and Not White Matter Lesions
Nils Schröter, Tobias Bormann, Michel Rijntjes, Ganna Blazhenets, Raissa Berti, Bastian E.A. Sajonz, Horst Urbach, Cornelius Weiller, Philipp T. Meyer, Alexander Rau, Lars Frings
Movement Disorders Clinical Practice.2023; 10(7): 1066. CrossRef - Orthostatic hypotension and its association with cerebral small vessel disease in a memory clinic population
Julia H.I. Wiersinga, Hanneke F.M. Rhodius-Meester, Frank J. Wolters, Marijke C. Trappenburg, Afina W. Lemstra, Frederik Barkhof, Mike J.L. Peters, Wiesje M. van der Flier, Majon Muller
Journal of Hypertension.2023; 41(11): 1738. CrossRef - Mild cognitive impairment in patients with Parkinson´s disease and the analysis of associated factors
Esma Kobak Tur, Buse Cagla Ari
Neurological Research.2023; 45(12): 1161. CrossRef - REM sleep behavioral disorder may be an independent risk factor for orthostatic hypotension in Parkinson’s disease
Kangfu Yin, Chuanbin Zhou, Yongyun Zhu, Weifang Yin, Lei Yin, Bin Liu, Hui Ren, Zhong Xu, Xinglong Yang
Aging Clinical and Experimental Research.2022; 34(1): 159. CrossRef - Parkinsonism and cerebrovascular disease
Manisha Narasimhan, Raymond Schwartz, Glenda Halliday
Journal of the Neurological Sciences.2022; 433: 120011. CrossRef - Arterial Blood Pressure Variability and Other Vascular Factors Contribution to the Cognitive Decline in Parkinson’s Disease
Anna Pierzchlińska, Magdalena Kwaśniak-Butowska, Jarosław Sławek, Marek Droździk, Monika Białecka
Molecules.2021; 26(6): 1523. CrossRef - Adverse effects of hypertension, supine hypertension, and perivascular space on cognition and motor function in PD
Na-Young Shin, Yae Won Park, Sang-Won Yoo, Ji-Yeon Yoo, Yangsean Choi, Jinhee Jang, Kook-Jin Ahn, Bum-soo Kim, Joong-Seok Kim
npj Parkinson's Disease.2021;[Epub] CrossRef - Association of Orthostatic Hypotension With Cerebral Atrophy in Patients With Lewy Body Disorders
Andrea Pilotto, Alberto Romagnolo, Andrea Scalvini, Mario Masellis, Yasushi Shimo, Laura Bonanni, Richard Camicioli, Lily L. Wang, Alok K. Dwivedi, Katherine Longardner, Federico Rodriguez-Porcel, Mark DiFrancesco, Joaquin A. Vizcarra, Elisa Montanaro, Si
Neurology.2021; 97(8): e814. CrossRef - Small vessel disease pathological changes in neurodegenerative and vascular dementias concomitant with autonomic dysfunction
Yoshiki Hase, Tuomo M. Polvikoski, Michael J. Firbank, Lucinda J. L. Craggs, Emily Hawthorne, Charlotte Platten, William Stevenson, Vincent Deramecourt, Clive Ballard, Rose Anne Kenny, Robert H. Perry, Paul Ince, Roxana O. Carare, Louise M. Allan, Karen H
Brain Pathology.2020; 30(1): 191. CrossRef - Neurovascular unit dysregulation, white matter disease, and executive dysfunction: the shared triad of vascular cognitive impairment and Alzheimer disease
Alexander Levit, Vladimir Hachinski, Shawn N. Whitehead
GeroScience.2020; 42(2): 445. CrossRef - The impact of supine hypertension on target organ damage and survival in patients with synucleinopathies and neurogenic orthostatic hypotension
Jose-Alberto Palma, Gabriel Redel-Traub, Angelo Porciuncula, Daniela Samaniego-Toro, Patricio Millar Vernetti, Yvonne W. Lui, Lucy Norcliffe-Kaufmann, Horacio Kaufmann
Parkinsonism & Related Disorders.2020; 75: 97. CrossRef - White Matter Hyperintensities in the Synucleinopathies: Orthostatic Hypotension, Supine Hypertension, or Both?
Horacio Kaufmann, Jose‐Alberto Palma
Movement Disorders Clinical Practice.2020; 7(6): 595. CrossRef - White Matter Hyperintensities Mediate Impact of Dysautonomia on Cognition in Parkinson's Disease
Mahsa Dadar, Seyed‐Mohammad Fereshtehnejad, Yashar Zeighami, Alain Dagher, Ronald B. Postuma, D. Louis Collins
Movement Disorders Clinical Practice.2020; 7(6): 639. CrossRef - Blood pressure lability is associated with subcortical atrophy in early Parkinson's disease
Sang-Won Yoo, Eunkyeong Yun, Mirim Bang, Uicheul Yoon, Ji-Yeon Yoo, Kwang-Soo Lee, Na-Young Shin, Joong-Seok Kim
Journal of Hypertension.2020; 38(10): 2043. CrossRef - Orthostatic hypotension, dizziness, neurology outcomes, and death in older adults
Stephen P. Juraschek, W.T. Longstreth, Oscar L. Lopez, John S. Gottdiener, Lewis A. Lipsitz, Lewis H. Kuller, Kenneth J. Mukamal
Neurology.2020; 95(14): e1941. CrossRef - Cross-sectional and longitudinal associations between total and regional white matter hyperintensity volume and cognitive and motor function in Parkinson's disease
Vincent Pozorski, Jennifer M. Oh, Ozioma Okonkwo, Stephanie Krislov, Amy Barzgari, Frances Theisen, Jitka Sojkova, Barbara B. Bendlin, Sterling C. Johnson, Catherine L. Gallagher
NeuroImage: Clinical.2019; 23: 101870. CrossRef - Magnetic Resonance Imaging–Visible Perivascular Spaces in Basal Ganglia Predict Cognitive Decline in Parkinson's Disease
Yae Won Park, Na‐Young Shin, Seok Jong Chung, Jiwoong Kim, Soo Mee Lim, Phil Hyu Lee, Seung‐Koo Lee, Kook Jin Ahn
Movement Disorders.2019; 34(11): 1672. CrossRef - Orthostatic hypotension in Parkinson disease
Ylva Hivand Hiorth, Kenn Freddy Pedersen, Ingvild Dalen, Ole-Bjørn Tysnes, Guido Alves
Neurology.2019; 93(16): e1526. CrossRef - Dysautonomia is associated with structural and functional alterations in Parkinson disease
Seok Jong Chung, Youn Jung Bae, Suhnyoung Jun, Han Soo Yoo, Seung Woo Kim, Yang Hyun Lee, Young H. Sohn, Seung-Koo Lee, Joon-Kyung Seong, Phil Hyu Lee
Neurology.2019; 92(13): e1456. CrossRef - Consensus statement on the definition of neurogenic supine hypertension in cardiovascular autonomic failure by the American Autonomic Society (AAS) and the European Federation of Autonomic Societies (EFAS)
Alessandra Fanciulli, Jens Jordan, Italo Biaggioni, Giovanna Calandra–Buonaura, William P. Cheshire, Pietro Cortelli, Sabine Eschlboeck, Guido Grassi, Max J. Hilz, Horacio Kaufmann, Heinz Lahrmann, Giuseppe Mancia, Gert Mayer, Lucy Norcliffe–Kaufmann, Ann
Clinical Autonomic Research.2018; 28(4): 355. CrossRef - Reverse blood pressure dipping as marker of dysautonomia in Parkinson disease
Valeria Milazzo, Cristina Di Stefano, Fabrizio Vallelonga, Gabriele Sobrero, Maurizio Zibetti, Alberto Romagnolo, Aristide Merola, Alberto Milan, Alberto J. Espay, Leonardo Lopiano, Franco Veglio, Simona Maule
Parkinsonism & Related Disorders.2018; 56: 82. CrossRef - White matter hyperintensities are linked to future cognitive decline in de novo Parkinson's disease patients
Mahsa Dadar, Yashar Zeighami, Yvonne Yau, Seyed-Mohammad Fereshtehnejad, Josefina Maranzano, Ronald B. Postuma, Alain Dagher, D. Louis Collins
NeuroImage: Clinical.2018; 20: 892. CrossRef - Rapid Systolic Blood Pressure Changes After Standing Up Associate With Impaired Physical Performance in Geriatric Outpatients
Arjen Mol, Esmee M. Reijnierse, Marijke C. Trappenburg, Richard J. A. van Wezel, Andrea B. Maier, Carel G. M. Meskers
Journal of the American Heart Association.2018;[Epub] CrossRef - Central hemodynamics and arterial stiffness in idiopathic and multiple system atrophy
Klaas Franzen, Sabine Fliegen, Jelena Koester, Rafael Campos Martin, Günther Deuschl, Michael Reppel, Kai Mortensen, Susanne A. Schneider
Journal of Neurology.2017; 264(2): 327. CrossRef - Cardiovascular Autonomic Dysfunction in Patients with Drug-Induced Parkinsonism
Joong-Seok Kim, Dong-Woo Ryu, Ju-Hee Oh, Yang-Hyun Lee, Sung-Jin Park, Kipyung Jeon, Jong-Yun Lee, Seong Hee Ho, Jungmin So, Jin Hee Im, Kwang-Soo Lee
Journal of Clinical Neurology.2017; 13(1): 15. CrossRef - Association of arterial stiffness with cognition in patients with Lewy body disorder
Dong-Woo Ryu, Joong-Seok Kim, Jee-Eun Lee, Jeong-Wook Park, Yoon-Sang Oh, Jae-Young An, Kwang-Soo Lee
Neurological Sciences.2017; 38(7): 1307. CrossRef - Microstructural integrity of white matter tracts amongst older fallers: A DTI study
Yoke Queen Wong, Li Kuo Tan, Pohchoo Seow, Maw Pin Tan, Khairul Azmi Abd Kadir, Anushya Vijayananthan, Norlisah Ramli, Gianluigi Forloni
PLOS ONE.2017; 12(6): e0179895. CrossRef - Cerebral autoregulation is preserved in multiple sclerosis patients
Daniel Ferreira, Pedro Castro, Gonçalo Videira, João Pedro Filipe, Rosa Santos, Maria José Sá, Elsa Azevedo, Pedro Abreu
Journal of the Neurological Sciences.2017; 381: 298. CrossRef - Long-term Levodopa Treatment Accelerates the Circadian Rhythm Dysfunction in a 6-hydroxydopamine Rat Model of Parkinson's Disease
Si-Yue Li, Ya-Li Wang, Wen-Wen Liu, Dong-Jun Lyu, Fen Wang, Cheng-Jie Mao, Ya-Ping Yang, Li-Fang Hu, Chun-Feng Liu
Chinese Medical Journal.2017; 130(9): 1085. CrossRef - Arterial Stiffness and Cardiovascular Autonomic Dysfunction in Patients with Parkinson's Disease
Joong-Seok Kim, Si-Hoon Lee, Yoon-Sang Oh, Jeong-Wook Park, Jae-Young An, Hyun-Seok Choi, Kwang-Soo Lee
Neurodegenerative Diseases.2017; 17(2-3): 89. CrossRef - Cardiovascular autonomic dysfunctions in elderly patients with essential tremor: comparison with healthy controls
Joong-Seok Kim, Yoon-Sang Oh, Hyung-Eun Park, Si-Hoon Lee, Jeong-Wook Park, In-Uk Song, Jae-Young An, Hun-Jun Park, Byung-Chul Son, Kwang-Soo Lee
Neurological Sciences.2016; 37(5): 711. CrossRef - Orthostatic hypotension and cardiac sympathetic denervation in Parkinson disease patients with REM sleep behavioral disorder
Joong-Seok Kim, Hyung-Eun Park, Yoon-Sang Oh, Si-Hoon Lee, Jeong-Wook Park, Byung-chul Son, Kwang-Soo Lee
Journal of the Neurological Sciences.2016; 362: 59. CrossRef - Supine hypertension in Parkinson’s disease and multiple system atrophy
Alessandra Fanciulli, Georg Göbel, Jean Pierre Ndayisaba, Roberta Granata, Susanne Duerr, Stefano Strano, Carlo Colosimo, Werner Poewe, Francesco E. Pontieri, Gregor K. Wenning
Clinical Autonomic Research.2016; 26(2): 97. CrossRef - Orthostatic hypotension and cognitive impairment in Parkinson's disease: Causation or association?
Claire McDonald, Julia L. Newton, David J. Burn
Movement Disorders.2016; 31(7): 937. CrossRef - Cardiovascular Autonomic Dysfunction in Mild and Advanced Parkinson’s Disease
Joong-Seok Kim, Si-Hoon Lee, Yoon-Sang Oh, Jeong-Wook Park, Jae-Young An, Sung-Kyung Park, Si-Ryung Han, Kwang-Soo Lee
Journal of Movement Disorders.2016; 9(2): 97. CrossRef - Autonomic Nervous System Dysfunction in Patients With Parkinson Disease Having Depression
Hyung-Eun Park, Joong-Seok Kim, Yoon-Sang Oh, In-Seok Park, Jeong-Wook Park, In-Uk Song, Kwang-Soo Lee
Journal of Geriatric Psychiatry and Neurology.2016; 29(1): 11. CrossRef - Vascular cognitive impairment, a cardiovascular complication
Adiukwu Frances, Ofori Sandra, Ugbomah Lucy
World Journal of Psychiatry.2016; 6(2): 199. CrossRef - Cardiovascular complications in patients with autonomic failure
Valeria Milazzo, Cristina Di Stefano, Alberto Milan, Agnese Ravera, Gabriele Sobrero, Luca Sabia, Franco Veglio, Simona Maule
Clinical Autonomic Research.2015; 25(3): 133. CrossRef - 123I-MIBG myocardial scintigraphy and neurocirculatory abnormalities in patients with dementia with Lewy bodies and Alzheimer's disease
Joong-Seok Kim, Hyung-Eun Park, Yoon-Sang Oh, In-Uk Song, Dong-Won Yang, Jeong-Wook Park, Kwang-Soo Lee
Journal of the Neurological Sciences.2015; 357(1-2): 173. CrossRef - Diagnosing and treating neurogenic orthostatic hypotension in primary care
Louis Kuritzky, Alberto J. Espay, Jeffrey Gelblum, Richard Payne, Eric Dietrich
Postgraduate Medicine.2015; 127(7): 702. CrossRef - Increased CSF biomarkers of angiogenesis in Parkinson disease
Shorena Janelidze, Daniel Lindqvist, Veronica Francardo, Sara Hall, Henrik Zetterberg, Kaj Blennow, Charles H. Adler, Thomas G. Beach, Geidy E. Serrano, Danielle van Westen, Elisabet Londos, M. Angela Cenci, Oskar Hansson
Neurology.2015; 85(21): 1834. CrossRef - Orthostatic hypotension, cerebral hypoperfusion, and visuospatial deficits in Lewy body disorders
Andrew D. Robertson, Michelle A. Messner, Zahra Shirzadi, Galit Kleiner-Fisman, Joyce Lee, Julia Hopyan, Anthony E. Lang, Sandra E. Black, Bradley J. MacIntosh, Mario Masellis
Parkinsonism & Related Disorders.2015;[Epub] CrossRef - Orthostatic Hypotension and Cognitive Impairment in <i>De Novo</i> Patients with Parkinson’s Disease
Hyo-Jin Bae, Jun-Ho Lim, Sang-Myung Cheon
Journal of Movement Disorders.2014; 7(2): 102. CrossRef
- Association Between Gait and Dysautonomia in Patients With De Novo Parkinson’s Disease: Forward Gait Versus Backward Gait
Review Articles
- Modeling α-Synuclein Propagation with Preformed Fibril Injections
- Hyun Kyung Chung, Hoang-Anh Ho, Dayana Pérez-Acuña, Seung-Jae Lee
- J Mov Disord. 2019;12(3):139-151. Published online September 30, 2019
- DOI: https://doi.org/10.14802/jmd.19046
- Correction in: J Mov Disord 2020;13(1):77
- 15,304 View
- 845 Download
- 48 Citations
-
Abstract
PDF
- The aggregation of α-synuclein (α-syn) has been implicated in the pathogenesis of many neurodegenerative disorders, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). Postmortem analyses of α-syn pathology, especially that of PD, have suggested that aggregates progressively spread from a few discrete locations to wider brain regions. The neuron-to-neuron propagation of α-syn has been suggested to be the underlying mechanism by which aggregates spread throughout the brain. Many cellular and animal models has been created to study cell-to-cell propagation. Recently, it has been shown that a single injection of preformed fibrils (PFFs) made of recombinant α-syn proteins into various tissues and organs of many different animal species results in widespread α-syn pathology in the central nervous system (CNS). These PFF models have been extensively used to study the mechanism by which aggregates spread throughout the brain. Here, we review what we have learned from PFF models, describe the nature of PFFs and the neuropathological features, neurophysiological characteristics, and behavioral outcomes of the models.
-
Citations
Citations to this article as recorded by- Non-invasive Monitoring of α-Synuclein in Saliva for Parkinson’s Disease Using Organic Electrolyte-Gated FET Aptasensor
Roslyn S. Massey, Erin M. McConnell, Dennis Chan, Matthew R. Holahan, Maria C. DeRosa, Ravi Prakash
ACS Sensors.2023; 8(8): 3116. CrossRef - CSF-derived extracellular vesicles from patients with Parkinson’s disease induce symptoms and pathology
Shay Herman, Ruth Djaldetti, Brit Mollenhauer, Daniel Offen
Brain.2023; 146(1): 209. CrossRef - Overexpression-Induced α-Synuclein Brain Spreading
Rita Pinto-Costa, Eugenia Harbachova, Pietro La Vitola, Donato A. Di Monte
Neurotherapeutics.2023; 20(1): 83. CrossRef - The Role of α-Synuclein in the Regulation of Serotonin System: Physiological and Pathological Features
Lluis Miquel-Rio, Unai Sarriés-Serrano, Rubén Pavia-Collado, J Javier Meana, Analia Bortolozzi
Biomedicines.2023; 11(2): 541. CrossRef - α‐Synuclein decoy peptide protects mice against α‐synuclein‐induced memory loss
Qingyun Guo, Ichiro Kawahata, Wenbin Jia, Haoyang Wang, An Cheng, Yasushi Yabuki, Norifumi Shioda, Kohji Fukunaga
CNS Neuroscience & Therapeutics.2023; 29(6): 1547. CrossRef - Duodenal alpha‐Synuclein Pathology and Enteric Gliosis in Advanced Parkinson's Disease
Aron Emmi, Michele Sandre, Francesco Paolo Russo, Giulia Tombesi, Federica Garrì, Marta Campagnolo, Miryam Carecchio, Roberta Biundo, Gaya Spolverato, Veronica Macchi, Edoardo Savarino, Fabio Farinati, Piero Parchi, Andrea Porzionato, Luigi Bubacco, Raffa
Movement Disorders.2023; 38(5): 885. CrossRef - Retina-to-brain spreading of α-synuclein after intravitreal injection of preformed fibrils
Dayana Pérez-Acuña, Ka Hyun Rhee, Soo Jean Shin, Jeeyun Ahn, Jee-Young Lee, Seung-Jae Lee
Acta Neuropathologica Communications.2023;[Epub] CrossRef - Apathy in Parkinson’s Disease: Clinical Patterns and Neurobiological Basis
Matthieu Béreau, Vincent Van Waes, Mathieu Servant, Eloi Magnin, Laurent Tatu, Mathieu Anheim
Cells.2023; 12(12): 1599. CrossRef - Translating Pathological Brain Activity Primers in Parkinson’s Disease Research
Daniela Mirzac, Svenja L. Kreis, Heiko J. Luhmann, Gabriel Gonzalez-Escamilla, Sergiu Groppa
Research.2023;[Epub] CrossRef - Animal models of Parkinson’s disease: bridging the gap between disease hallmarks and research questions
Axelle Dovonou, Cyril Bolduc, Victoria Soto Linan, Charles Gora, Modesto R. Peralta III, Martin Lévesque
Translational Neurodegeneration.2023;[Epub] CrossRef - The Poly-Arginine Peptide R18D Interferes with the Internalisation of α-Synuclein Pre-Formed Fibrils in STC-1 Enteroendocrine Cells
Anastazja M. Gorecki, Holly Spencer, Bruno P. Meloni, Ryan S. Anderton
Biomedicines.2023; 11(8): 2089. CrossRef - Alpha‐synuclein fibrils amplified from multiple system atrophy and Parkinson's disease patient brain spread after intracerebral injection into mouse brain
Shuyu Zhang, Karina Dauer, Timo Strohäker, Lars Tatenhorst, Lucas Caldi Gomes, Simon Mayer, Byung Chul Jung, Woojin S. Kim, Seung‐Jae Lee, Stefan Becker, Friederike Liesche‐Starnecker, Markus Zweckstetter, Paul Lingor
Brain Pathology.2023;[Epub] CrossRef - Aging, Parkinson’s Disease, and Models: What Are the Challenges?
Emily Rocha, Manish Chamoli, Shankar J. Chinta, Julie K. Andersen, Ruby Wallis, Erwan Bezard, Matt Goldberg, Tim Greenamyre, Warren Hirst, We-Li Kuan, Deniz Kirik, Laura Niedernhofer, Irit Rappley, Shalini Padmanabhan, Louis-Eric Trudeau, Maria Spillantin
Aging Biology.2023; 1(1): 20230010. CrossRef - A Novel NOX Inhibitor Alleviates Parkinson’s Disease Pathology in PFF-Injected Mice
Kwadwo Ofori, Anurupa Ghosh, Dinesh Kumar Verma, Darice Wheeler, Gabriela Cabrera, Jong-Bok Seo, Yong-Hwan Kim
International Journal of Molecular Sciences.2023; 24(18): 14278. CrossRef - Cortical Lewy body injections induce long-distance pathogenic alterations in the non-human primate brain
Margaux Teil, Sandra Dovero, Mathieu Bourdenx, Marie-Laure Arotcarena, Morgane Darricau, Gregory Porras, Marie-Laure Thiolat, Inés Trigo-Damas, Celine Perier, Cristina Estrada, Nuria Garcia-Carrillo, María Trinidad Herrero, Miquel Vila, José A. Obeso, Erw
npj Parkinson's Disease.2023;[Epub] CrossRef - DA-9805 protects dopaminergic neurons from endoplasmic reticulum stress and inflammation
Sora Kang, Ying Piao, Young Cheol Kang, Suyeol Lim, Youngmi Kim Pak
Biomedicine & Pharmacotherapy.2022; 145: 112389. CrossRef - Endogenous Levels of Alpha-Synuclein Modulate Seeding and Aggregation in Cultured Cells
Eftychia Vasili, Antonio Dominguez-Meijide, Manuel Flores-León, Mohammed Al-Azzani, Angeliki Kanellidi, Ronald Melki, Leonidas Stefanis, Tiago Fleming Outeiro
Molecular Neurobiology.2022; 59(2): 1273. CrossRef - Phosphorylation of endogenous α-synuclein induced by extracellular seeds initiates at the pre-synaptic region and spreads to the cell body
Shiori Awa, Genjiro Suzuki, Masami Masuda-Suzukake, Takashi Nonaka, Minoru Saito, Masato Hasegawa
Scientific Reports.2022;[Epub] CrossRef - Evidence of Inflammation in Parkinson’s Disease and Its Contribution to Synucleinopathy
Thuy Thi Lai, Yun Joong Kim, Hyeo-il Ma, Young Eun Kim
Journal of Movement Disorders.2022; 15(1): 1. CrossRef - α-Synuclein in Parkinson's disease and advances in detection
Rong Chen, Xuan Gu, Xiaoying Wang
Clinica Chimica Acta.2022; 529: 76. CrossRef - Neurons with Cat’s Eyes: A Synthetic Strain of α-Synuclein Fibrils Seeding Neuronal Intranuclear Inclusions
Francesca De Giorgi, Muhammed Bilal Abdul-Shukkoor, Marianna Kashyrina, Leslie-Ann Largitte, Francesco De Nuccio, Brice Kauffmann, Alons Lends, Florent Laferrière, Sébastien Bonhommeau, Dario Domenico Lofrumento, Luc Bousset, Erwan Bezard, Thierry Buffete
Biomolecules.2022; 12(3): 436. CrossRef - A Novel NOX Inhibitor Treatment Attenuates Parkinson’s Disease-Related Pathology in Mouse Models
Anurupa A. Ghosh, Dinesh Kumar Verma, Gabriela Cabrera, Kwadwo Ofori, Karina Hernandez-Quijada, Jae-Kwan Kim, Joo Hee Chung, Michael Moore, Sung Hwan Moon, Jong Bok Seo, Yong-Hwan Kim
International Journal of Molecular Sciences.2022; 23(8): 4262. CrossRef - Do Naturally Occurring Antioxidants Protect Against Neurodegeneration
of the Dopaminergic System? A Systematic Revision in Animal Models of
Parkinson's Disease
Carmen Costas, Lilian R.F. Faro
Current Neuropharmacology.2022; 20(2): 432. CrossRef - NXP031 prevents dopaminergic neuronal loss and oxidative damage in the AAV-WT-α-synuclein mouse model of Parkinson’s disease
Min Kyung Song, Levi Adams, Joo Hee Lee, Yoon-Seong Kim, Hemant K. Paudel
PLOS ONE.2022; 17(7): e0272085. CrossRef - Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo
Rachel E. Lackie, Aline S. de Miranda, Mei Peng Lim, Vladislav Novikov, Nimrod Madrer, Nadun C. Karunatilleke, Benjamin S. Rutledge, Stephanie Tullo, Anne Brickenden, Matthew E. R. Maitland, David Greenberg, Daniel Gallino, Wen Luo, Anoosha Attaran, Irina
Acta Neuropathologica.2022; 144(5): 881. CrossRef - Nanomedicine in the Face of Parkinson’s Disease: From Drug Delivery Systems to Nanozymes
Francisco J. Padilla-Godínez, Leonardo I. Ruiz-Ortega, Magdalena Guerra-Crespo
Cells.2022; 11(21): 3445. CrossRef - Animal Models of Metabolic Disorders in the Study of Neurodegenerative Diseases: An Overview
Andreza Fabro de Bem, Rachel Krolow, Hémelin Resende Farias, Victória Linden de Rezende, Daniel Pens Gelain, José Cláudio Fonseca Moreira, João Miguel das Neves Duarte, Jade de Oliveira
Frontiers in Neuroscience.2021;[Epub] CrossRef - Role of Liver Growth Factor (LGF) in Parkinson’s Disease: Molecular Insights and Therapeutic Opportunities
Efthalia Angelopoulou, Yam Nath Paudel, Christina Piperi
Molecular Neurobiology.2021; 58(7): 3031. CrossRef - Trans-synaptic spreading of alpha-synuclein pathology through sensory afferents leads to sensory nerve degeneration and neuropathic pain
Nelson Ferreira, Nádia Pereira Gonçalves, Asad Jan, Nanna Møller Jensen, Amelia van der Laan, Simin Mohseni, Christian Bjerggaard Vægter, Poul Henning Jensen
Acta Neuropathologica Communications.2021;[Epub] CrossRef - Pharmacological Inhibition of Brain EGFR Activation By a BBB-penetrating Inhibitor, AZD3759, Attenuates α-synuclein Pathology in a Mouse Model of α-Synuclein Propagation
Omid Tavassoly, Esther del Cid Pellitero, Frederique Larroquette, Eddie Cai, Rhalena A. Thomas, Vincent Soubannier, Wen Luo, Thomas M. Durcan, Edward A. Fon
Neurotherapeutics.2021; 18(2): 979. CrossRef - The Future of Incretin-Based Approaches for Neurodegenerative Diseases in Older Adults: Which to Choose? A Review of their Potential Efficacy and Suitability
Christine Girges, Nirosen Vijiaratnam, Dilan Athauda, Grace Auld, Sonia Gandhi, Thomas Foltynie
Drugs & Aging.2021; 38(5): 355. CrossRef - Prodromal neuroinvasion of pathological α-synuclein in brainstem reticular nuclei and white matter lesions in a model of α-synucleinopathy
Nelson Ferreira, Mette Richner, Amelia van der Laan, Ida Bergholdt Jul Christiansen, Christian B Vægter, Jens R Nyengaard, Glenda M Halliday, Joachim Weis, Benoit I Giasson, Ian R Mackenzie, Poul H Jensen, Asad Jan
Brain Communications.2021;[Epub] CrossRef - Impact of the apelin/APJ axis in the pathogenesis of Parkinson’s disease with therapeutic potential
Efthalia Angelopoulou, Yam Nath Paudel, Anastasia Bougea, Christina Piperi
Journal of Neuroscience Research.2021; 99(9): 2117. CrossRef - Adenovirus-induced Reactive Astrogliosis Exacerbates the Pathology of Parkinson’s Disease
Heeyoung An, Hyowon Lee, Seulkee Yang, Woojin Won, C. Justin Lee, Min-Ho Nam
Experimental Neurobiology.2021; 30(3): 222. CrossRef - Brain iron enrichment attenuates α‐synuclein spreading after injection of preformed fibrils
Karina Dauer née Joppe, Lars Tatenhorst, Lucas Caldi Gomes, Shuyu Zhang, Mojan Parvaz, Eleonora Carboni, Anna‐Elisa Roser, Hazem El DeBakey, Mathias Bähr, Katarina Vogel‐Mikuš, Chi Wang Ip, Stefan Becker, Markus Zweckstetter, Paul Lingor
Journal of Neurochemistry.2021; 159(3): 554. CrossRef - Increased oscillatory power in a computational model of the olfactory bulb due to synaptic degeneration
J. Kendall Berry, Daniel Cox
Physical Review E.2021;[Epub] CrossRef - Combining Automated Organoid Workflows with Artificial Intelligence‐Based Analyses: Opportunities to Build a New Generation of Interdisciplinary High‐Throughput Screens for Parkinson's Disease and Beyond
Henrik Renner, Hans R. Schöler, Jan M. Bruder
Movement Disorders.2021; 36(12): 2745. CrossRef - Is Multiple System Atrophy a Prion-like Disorder?
Kurt A. Jellinger, Gregor K. Wenning, Nadia Stefanova
International Journal of Molecular Sciences.2021; 22(18): 10093. CrossRef - Cortical alpha-synuclein preformed fibrils do not affect interval timing in mice
Qiang Zhang, Hisham Abdelmotilib, Travis Larson, Cameron Keomanivong, Mackenzie Conlon, Georgina M. Aldridge, Nandakumar S. Narayanan
Neuroscience Letters.2021; 765: 136273. CrossRef - Temporal Evolution of Inflammation and Neurodegeneration With Alpha-Synuclein Propagation in Parkinson's Disease Mouse Model
Thuy Thi Lai, Yun Joong Kim, Phuong Thi Nguyen, Young Ho Koh, Tinh Thi Nguyen, Hyeo-il Ma, Young Eun Kim
Frontiers in Integrative Neuroscience.2021;[Epub] CrossRef - The Concept of α-Synuclein Strains and How Different Conformations May Explain Distinct Neurodegenerative Disorders
Katja Malfertheiner, Nadia Stefanova, Antonio Heras-Garvin
Frontiers in Neurology.2021;[Epub] CrossRef - A historical review of multiple system atrophy with a critical appraisal of cellular and animal models
David J. Marmion, Wouter Peelaerts, Jeffrey H. Kordower
Journal of Neural Transmission.2021; 128(10): 1507. CrossRef - Exploring the Etiological Links behind Neurodegenerative Diseases: Inflammatory Cytokines and Bioactive Kynurenines
Masaru Tanaka, József Toldi, László Vécsei
International Journal of Molecular Sciences.2020; 21(7): 2431. CrossRef - Modeling Parkinson’s Disease With the Alpha-Synuclein Protein
Mónica Gómez-Benito, Noelia Granado, Patricia García-Sanz, Anne Michel, Mireille Dumoulin, Rosario Moratalla
Frontiers in Pharmacology.2020;[Epub] CrossRef - Enhanced Susceptibility of PINK1 Knockout Rats to α-Synuclein Fibrils
Rose B. Creed, Matthew S. Goldberg
Neuroscience.2020; 437: 64. CrossRef - Pathogenic Mutations Differentially Regulate Cell-to-Cell Transmission of α-Synuclein
Yuan Guan, Xiaofang Zhao, Fengwei Liu, Shuxin Yan, Yalong Wang, Cuilian Du, Xiuyu Cui, Rena Li, Claire Xi Zhang
Frontiers in Cellular Neuroscience.2020;[Epub] CrossRef - Dopamine, Alpha-Synuclein, and Mitochondrial Dysfunctions in Parkinsonian Eyes
Alessia Indrieri, Rocco Pizzarelli, Brunella Franco, Elvira De Leonibus
Frontiers in Neuroscience.2020;[Epub] CrossRef - Classic and evolving animal models in Parkinson's disease
Tanvi Pingale, Girdhari Lal Gupta
Pharmacology Biochemistry and Behavior.2020; 199: 173060. CrossRef
- Non-invasive Monitoring of α-Synuclein in Saliva for Parkinson’s Disease Using Organic Electrolyte-Gated FET Aptasensor
- Update on Current Technologies for Deep Brain Stimulation in Parkinson’s Disease
- Michelle Paff, Aaron Loh, Can Sarica, Andres M. Lozano, Alfonso Fasano
- J Mov Disord. 2020;13(3):185-198. Published online August 31, 2020
- DOI: https://doi.org/10.14802/jmd.20052
- 17,704 View
- 687 Download
- 46 Citations
-
Abstract
PDF
- Deep brain stimulation (DBS) is becoming increasingly central in the treatment of patients with Parkinson’s disease and other movement disorders. Recent developments in DBS lead and implantable pulse generator design provide increased flexibility for programming, potentially improving the therapeutic benefit of stimulation. Directional DBS leads may increase the therapeutic window of stimulation by providing a means of avoiding current spread to structures that might give rise to stimulation-related side effects. Similarly, control of current to individual contacts on a DBS lead allows for shaping of the electric field produced between multiple active contacts. The following review aims to describe the recent developments in DBS system technology and the features of each commercially available DBS system. The advantages of each system are reviewed, and general considerations for choosing the most appropriate system are discussed.
-
Citations
Citations to this article as recorded by- Spinal Cord Stimulation for Parkinson’s Disease: A Systematic Review and Meta-Analysis of Pain and Motor Outcomes
Can Sarica, Ajmal Zemmar, Omid Yousefi, Andrew C. Yang, Ayse Uzuner, Zhiyuan Sheng, Brendan Santyr, Nardin Samuel, Michael Colditz, Artur Vetkas, Jürgen Germann, Cletus Cheyuo, Mohammadmahdi Sabahi, Raja Niranjan Jani, Ghazaleh Darmani, Kazuaki Yamamoto,
Stereotactic and Functional Neurosurgery.2023; 101(4): 244. CrossRef - Long-term motor outcomes of deep brain stimulation of the globus pallidus interna in Parkinson's disease patients: Five-year follow-up
Yun Su Hwang, Sungyang Jo, Seung Hyun Lee, Nayoung Kim, Mi-Sun Kim, Sang Ryong Jeon, Sun Ju Chung
Journal of the Neurological Sciences.2023; 444: 120484. CrossRef - Implementing automation in deep brain stimulation: has the time come?
Marco Bonizzato, Alfonso Fasano
The Lancet Digital Health.2023; 5(2): e52. CrossRef - Proceedings of the 10th annual deep brain stimulation think tank: Advances in cutting edge technologies, artificial intelligence, neuromodulation, neuroethics, interventional psychiatry, and women in neuromodulation
Joshua K. Wong, Helen S. Mayberg, Doris D. Wang, R. Mark Richardson, Casey H. Halpern, Lothar Krinke, Mattia Arlotti, Lorenzo Rossi, Alberto Priori, Sara Marceglia, Ro’ee Gilron, James F. Cavanagh, Jack W. Judy, Svjetlana Miocinovic, Annaelle D. Devergnas
Frontiers in Human Neuroscience.2023;[Epub] CrossRef - Deep brain stimulation: new programming algorithms and teleprogramming
Renato Puppi Munhoz, Ghadh Albuainain
Expert Review of Neurotherapeutics.2023; 23(5): 467. CrossRef - Impact of modeled field of view in electroconvulsive therapy current flow simulations
Alexander Guillen, Christopher C. Abbott, Zhi-De Deng, Yu Huang, Paula Pascoal-Faria, Dennis Q. Truong, Abhishek Datta
Frontiers in Psychiatry.2023;[Epub] CrossRef - Access to device-aided therapies in advanced Parkinson’s disease: navigating clinician biases, patient preference, and prognostic uncertainty
Manon Auffret, Daniel Weiss, Fabrizio Stocchi, Marc Vérin, Wolfgang H. Jost
Journal of Neural Transmission.2023; 130(11): 1411. CrossRef - Multifunctional Fiber‐Based Optoacoustic Emitter as a Bidirectional Brain Interface
Nan Zheng, Ying Jiang, Shan Jiang, Jongwoon Kim, Guo Chen, Yueming Li, Ji‐Xin Cheng, Xiaoting Jia, Chen Yang
Advanced Healthcare Materials.2023;[Epub] CrossRef - Neurological Insights into Sleep Disorders in Parkinson’s Disease
Subramanian Thangaleela, Bhagavathi Sundaram Sivamaruthi, Periyanaina Kesika, Subramanian Mariappan, Subramanian Rashmi, Thiwanya Choeisoongnern, Phakkharawat Sittiprapaporn, Chaiyavat Chaiyasut
Brain Sciences.2023; 13(8): 1202. CrossRef - Investigation of a Deep Brain Stimulator (DBS) System
Jennifer Whitestone, Anmar Salih, Tarun Goswami
Bioengineering.2023; 10(10): 1160. CrossRef - Thirty Years of Global Deep Brain Stimulation: “Plus ça change, plus c’est la même chose”?
Marwan Hariz, Laura Cif, Patric Blomstedt
Stereotactic and Functional Neurosurgery.2023; : 1. CrossRef - The Safety to Switch from Constant Voltage to Constant Current with a Mixed Internal Pulse Generator in Deep Brain Stimulation
Gülşah Öztürk, Kemal Paksoy
Annals of Indian Academy of Neurology.2023; 26(4): 507. CrossRef - Advances in Deep Brain Stimulation: From Mechanisms to Applications
Stephanie S. Sandoval-Pistorius, Mallory L. Hacker, Allison C. Waters, Jing Wang, Nicole R. Provenza, Coralie de Hemptinne, Kara A. Johnson, Melanie A. Morrison, Stephanie Cernera
The Journal of Neuroscience.2023; 43(45): 7575. CrossRef - Brain stimulation treatments in epilepsy: Basic mechanisms and clinical advances
Thomas J. Foutz, Michael Wong
Biomedical Journal.2022; 45(1): 27. CrossRef - Neurodegenerative disorders management: state-of-art and prospects of nano-biotechnology
Raj Kumar, Keshaw Ram Aadil, Kunal Mondal, Yogendra Kumar Mishra, David Oupicky, Seeram Ramakrishna, Ajeet Kaushik
Critical Reviews in Biotechnology.2022; 42(8): 1180. CrossRef - Sleep and circadian rhythms in Parkinson’s disease and preclinical models
Jeremy Hunt, Elizabeth J. Coulson, Rajendram Rajnarayanan, Henrik Oster, Aleksandar Videnovic, Oliver Rawashdeh
Molecular Neurodegeneration.2022;[Epub] CrossRef - Jose Delgado: A controversial trailblazer in neuromodulation
Nicholas D. Lorusso, Uma R. Mohan, Joshua Jacobs
Artificial Organs.2022; 46(4): 531. CrossRef - Local and distant cortical responses to single pulse intracranial stimulation in the human brain are differentially modulated by specific stimulation parameters
Angelique C. Paulk, Rina Zelmann, Britni Crocker, Alik S. Widge, Darin D. Dougherty, Emad N. Eskandar, Daniel S. Weisholtz, R. Mark Richardson, G. Rees Cosgrove, Ziv M. Williams, Sydney S. Cash
Brain Stimulation.2022;[Epub] CrossRef - Proceedings of the Ninth Annual Deep Brain Stimulation Think Tank: Advances in Cutting Edge Technologies, Artificial Intelligence, Neuromodulation, Neuroethics, Pain, Interventional Psychiatry, Epilepsy, and Traumatic Brain Injury
Joshua K. Wong, Günther Deuschl, Robin Wolke, Hagai Bergman, Muthuraman Muthuraman, Sergiu Groppa, Sameer A. Sheth, Helen M. Bronte-Stewart, Kevin B. Wilkins, Matthew N. Petrucci, Emilia Lambert, Yasmine Kehnemouyi, Philip A. Starr, Simon Little, Juan Ans
Frontiers in Human Neuroscience.2022;[Epub] CrossRef - Past, Present, and Future of Deep Brain Stimulation: Hardware, Software, Imaging, Physiology and Novel Approaches
Jessica Frey, Jackson Cagle, Kara A. Johnson, Joshua K. Wong, Justin D. Hilliard, Christopher R. Butson, Michael S. Okun, Coralie de Hemptinne
Frontiers in Neurology.2022;[Epub] CrossRef - Parkinson’s Disease Management via Wearable Sensors: A Systematic Review
Huma Mughal, Abdul Rehman Javed, Muhammad Rizwan, Ahmad S. Almadhor, Natalia Kryvinska
IEEE Access.2022; 10: 35219. CrossRef - Conversion to Hybrid Deep Brain Stimulation System to Enable Multi‐Contact Fractionation Can be Therapeutic
Disep I. Ojukwu, Allan R. Wang, Traci S. Hornbeck, Erika A. Lim, Jennifer Sharrard, Rohit Dhall, Vivek P. Buch, Casey H. Halpern
Movement Disorders.2022; 37(6): 1321. CrossRef - Developments in Deep Brain Stimulators for Successful Aging Towards Smart Devices—An Overview
Angelito A. Silverio, Lean Angelo A. Silverio
Frontiers in Aging.2022;[Epub] CrossRef - Single-interface bioelectronic medicines—concept, clinical applications and preclinical data
Cristian Sevcencu
Journal of Neural Engineering.2022; 19(3): 031001. CrossRef - Current Steering Using Multiple Independent Current Control Deep Brain Stimulation Technology Results in Distinct Neurophysiological Responses in Parkinson’s Disease Patients
Jana Peeters, Alexandra Boogers, Tine Van Bogaert, Robin Gransier, Jan Wouters, Bart Nuttin, Myles Mc Laughlin
Frontiers in Human Neuroscience.2022;[Epub] CrossRef - Managing Intractable Symptoms of Parkinson's Disease: A Nonsurgical Approach Employing Infralow Frequency Neuromodulation
Stella B. Legarda, P. Andreas Michas-Martin, Dana McDermott
Frontiers in Human Neuroscience.2022;[Epub] CrossRef - Directional Deep Brain Stimulation in the Treatment of Parkinson's Disease
Akash Mishra, Ritesh A Ramdhani
Neurology.2022; 18(1): 64. CrossRef - Approach to the Treatment of Pediatric Dystonia
Carolina Gorodetsky, Alfonso Fasano
Dystonia.2022;[Epub] CrossRef - CRISPR and iPSCs: Recent Developments and Future Perspectives in Neurodegenerative Disease Modelling, Research, and Therapeutics
Tirthankar Sen, Rajkumar P. Thummer
Neurotoxicity Research.2022; 40(5): 1597. CrossRef - Encoding type, medication, and deep brain stimulation differentially affect memory-guided sequential reaching movements in Parkinson's disease
Fabian J. David, Yessenia M. Rivera, Tara K. Entezar, Rishabh Arora, Quentin H. Drane, Miranda J. Munoz, Joshua M. Rosenow, Sepehr B. Sani, Gian D. Pal, Leonard Verhagen-Metman, Daniel M. Corcos
Frontiers in Neurology.2022;[Epub] CrossRef - Remote programming for subthalamic deep brain stimulation in Parkinson's disease
Si Chen, Shu-jun Xu, Wei-guo Li, Teng Chen, Chao Li, Shuo Xu, Ning Yang, Yi-ming Liu
Frontiers in Neurology.2022;[Epub] CrossRef - Longevity of Deep Brain Stimulation Batteries; a Global Survey of Neurosurgeons and Neurologists
Marwan Hariz, Gun‐Marie Hariz, Patric Blomstedt
Movement Disorders.2021; 36(5): 1273. CrossRef - Basic Tips: How Do I Start Programming Deep Brain Stimulation in Parkinson Disease Patients?
Carolina Gorodetsky, Alfonso Fasano
Movement Disorders Clinical Practice.2021; 8(4): 639. CrossRef - Deep brain stimulation: Challenges at the tissue‐electrode interface and current solutions
Emily Kolaya, Bonnie L. Firestein
Biotechnology Progress.2021;[Epub] CrossRef - An Update on Medical and Surgical Treatments of Parkinson’s Disease
Dipali Nemade, Thyagarajan Subramanian, Vikram Shivkumar
Aging and disease.2021; 12(4): 1021. CrossRef - Experimental Characterization of Ferroelectric Capacitor Circuits for the Realization of Simply Designed Electroceuticals
Yves Olsommer, Frank R. Ihmig
Electronic Materials.2021; 2(3): 299. CrossRef - Flexible vs. standard subthalamic stimulation in Parkinson disease: A double-blind proof-of-concept cross-over trial
Derrick Soh, Ricardo Maciel, Musleh Algarni, Karlo Lizarraga, Aaron Loh, Jürgen Germann, Gavin Elias, Alexandre Boutet, Renato P. Munhoz, Suneil K. Kalia, Mojgan Hodaie, Andres M. Lozano, Alfonso Fasano
Parkinsonism & Related Disorders.2021; 89: 93. CrossRef - Telemedicine and Deep brain stimulation - Current practices and recommendations
Vibhash D. Sharma, Delaram Safarpour, Shyamal H. Mehta, Nora Vanegas-Arroyave, Daniel Weiss, Jeffrey W. Cooney, Zoltan Mari, Alfonso Fasano
Parkinsonism & Related Disorders.2021; 89: 199. CrossRef - Subspace-based predictive control of Parkinson’s disease: A model-based study
Mahboubeh Ahmadipour, Mojtaba Barkhordari-Yazdi, Saeid R. Seydnejad
Neural Networks.2021; 142: 680. CrossRef - Advances in Triboelectric Nanogenerators for Self‐Powered Regenerative Medicine
Samira Parandeh, Niloofar Etemadi, Mahshid Kharaziha, Guorui Chen, Ardo Nashalian, Xiao Xiao, Jun Chen
Advanced Functional Materials.2021;[Epub] CrossRef - Implantable Pulse Generators for Deep Brain Stimulation: Challenges, Complications, and Strategies for Practicality and Longevity
Can Sarica, Christian Iorio-Morin, David H. Aguirre-Padilla, Ahmed Najjar, Michelle Paff, Anton Fomenko, Kazuaki Yamamoto, Ajmal Zemmar, Nir Lipsman, George M. Ibrahim, Clement Hamani, Mojgan Hodaie, Andres M. Lozano, Renato P. Munhoz, Alfonso Fasano, Sun
Frontiers in Human Neuroscience.2021;[Epub] CrossRef - Microstimulation Is a Promising Approach in Achieving Better Lead Placement in Subthalamic Nucleus Deep Brain Stimulation Surgery
Lin Shi, Shiying Fan, Tianshuo Yuan, Huaying Fang, Jie Zheng, Zunyu Xiao, Yu Diao, Guanyu Zhu, Quan Zhang, Huanguang Liu, Hua Zhang, Fangang Meng, Jianguo Zhang, Anchao Yang
Frontiers in Neurology.2021;[Epub] CrossRef - Revisiting brain stimulation in Parkinson’s disease
Carola A. Haas
Science.2021; 374(6564): 153. CrossRef - A New Implantable Closed-Loop Clinical Neural Interface: First Application in Parkinson’s Disease
Mattia Arlotti, Matteo Colombo, Andrea Bonfanti, Tomasz Mandat, Michele Maria Lanotte, Elena Pirola, Linda Borellini, Paolo Rampini, Roberto Eleopra, Sara Rinaldo, Luigi Romito, Marcus L. F. Janssen, Alberto Priori, Sara Marceglia
Frontiers in Neuroscience.2021;[Epub] CrossRef - Update on Parkinson's Disease Therapy
Rebecca M Gilbert
Neurology.2021; 17(2): 92. CrossRef - Deep Brain Stimulation for Parkinson's Disease: Currents Status and Emerging Concepts
PareshK Doshi, Deepak Das
Neurology India.2020; 68(8): 179. CrossRef
- Spinal Cord Stimulation for Parkinson’s Disease: A Systematic Review and Meta-Analysis of Pain and Motor Outcomes
- Clinical Approach to Progressive Supranuclear Palsy
- Helen Ling
- J Mov Disord. 2016;9(1):3-13. Published online January 25, 2016
- DOI: https://doi.org/10.14802/jmd.15060
- 33,721 View
- 1,204 Download
- 45 Citations
-
Abstract
PDF
- Sixty years ago, Steele, Richardson and Olszewski designated progressive supranuclear palsy (PSP) as a new clinicopathological entity in their seminal paper. Since then, in addition to the classic Richardson’s syndrome (RS), different clinical phenotypic presentations have been linked with this four-repeat tauopathy. The clinical heterogeneity is associated with variability of regional distribution and severity of abnormal tau accumulation and neuronal loss. In PSP subtypes, the presence of certain clinical pointers may be useful for antemortem prediction of the underlying PSP-tau pathology. Midbrain atrophy on conventional MRI correlates with the clinical phenotype of RS but is not predictive of PSP pathology. Cerebrospinal fluid biomarkers and tau ligand positron emission tomography are promising biomarkers of PSP. A multidisciplinary approach to meet the patients’ complex needs is the current core treatment strategy for this devastating disorder.
-
Citations
Citations to this article as recorded by- Existing statistical measures and techniques in detecting and evaluating progressive supranuclear palsy, its phenotypes by using MRI modalities: A Review
Nirmal Adam Sait, J Kathirvelan
Materials Today: Proceedings.2023; 80: 2000. CrossRef - The role of magnetic resonance imaging in the diff erential diagnosis of Parkinson’s disease
A. A. Tappakhov, T. E. Popova
Russian neurological journal.2023; 28(1): 5. CrossRef - PSP-Richardson syndrome mimics: An overview and pragmatic approach
J. Necpál, M. Borsek, B. Jeleňová
Revue Neurologique.2023;[Epub] CrossRef - Clinical features of progressive supranuclear palsy
Yafei Wen, Qijie Yang, Bin Jiao, Weiwei Zhang, Jingyi Lin, Yuan Zhu, Qian Xu, Hui Zhou, Ling Weng, Xinxin Liao, Yafang Zhou, Junling Wang, Jifeng Guo, Xinxiang Yan, Hong Jiang, Beisha Tang, Lu Shen
Frontiers in Aging Neuroscience.2023;[Epub] CrossRef - Midbrain area and the hummingbird sign from brain MRI in progressive supranuclear palsy and idiopathic normal pressure hydrocephalus
Johan Virhammar, Harald Blohmé, Dag Nyholm, Charalampos Georgiopoulos, David Fällmar
Journal of Neuroimaging.2022; 32(1): 90. CrossRef - Cognitive, Psychiatric, and Motor Symptoms–Based Algorithmic Approach to Differentiate Among Various Types of Dementia Syndromes
Rehab Magdy, Mona Hussein
Journal of Nervous & Mental Disease.2022; 210(2): 129. CrossRef - Idiopathic normal pressure hydrocephalus-like MRI features in patients with progressive supranuclear palsy: a comparative case-control study
Halil Onder, Bilge Kocer, Selcuk Comoglu
Neurological Research.2022; 44(9): 807. CrossRef - Targeting alpha-synuclein or tau for treating neurodegenerative movement disorders
M. Lopez-Cuina, W.G. Meissner
Revue Neurologique.2022; 178(5): 460. CrossRef - Clinical Aspects of the Differential Diagnosis of Parkinson’s Disease and Parkinsonism
Hae-Won Shin, Sang-Wook Hong, Young Chul Youn
Journal of Clinical Neurology.2022; 18(3): 259. CrossRef - Dopamine transporter imaging in progressive supranuclear palsy: Severe but nonspecific to subtypes
Qi‐Si Chen, Xin‐Yi Li, Ling Li, Jia‐Ying Lu, Yi‐Min Sun, Feng‐Tao Liu, Chuan‐Tao Zuo, Jian Wang
Acta Neurologica Scandinavica.2022; 146(3): 237. CrossRef - CSF tau microtubule-binding region identifies pathological changes in primary tauopathies
Kanta Horie, Nicolas R. Barthélemy, Salvatore Spina, Lawren VandeVrede, Yingxin He, Ross W. Paterson, Brenton A. Wright, Gregory S. Day, Albert A. Davis, Celeste M. Karch, William W. Seeley, Richard J. Perrin, Rama K. Koppisetti, Faris Shaikh, Argentina L
Nature Medicine.2022; 28(12): 2547. CrossRef - Role of Multivoxel MR Spectroscopy Progressive Supranuclear Palsy – A Preliminary Study
Sandhya Mangalore, Manoj Kumar, Pramod Pal, Jitender Saini, Shaik Pasha, Ravi Yadav
Neurology India.2022; 70(6): 2388. CrossRef - Genetics of Progressive Supranuclear Palsy: A Review
Yafei Wen, Yafang Zhou, Bin Jiao, Lu Shen
Journal of Parkinson's Disease.2021; 11(1): 93. CrossRef - Disease course and treatment patterns in progressive supranuclear palsy: A real-world study
John C. Morgan, Xiaolan Ye, Jennifer A. Mellor, Keisha J. Golden, Jorge Zamudio, Louis A. Chiodo, Yanjun Bao, Tao Xie
Journal of the Neurological Sciences.2021; 421: 117293. CrossRef - Central nystagmus in progressive supranuclear palsy: A neglected clinical feature?
Maja Klarendic, Manja Hribar, Nina Bozanic Urbancic, Nina Zupancic, Milica G. Kramberger, Maja Trost, Saba Battelino, Diego Kaski, Maja Kojovic
Parkinsonism & Related Disorders.2021; 84: 15. CrossRef - Safety and efficacy of tilavonemab in progressive supranuclear palsy: a phase 2, randomised, placebo-controlled trial
Günter U Höglinger, Irene Litvan, Nuno Mendonca, Deli Wang, Hui Zheng, Beatrice Rendenbach-Mueller, Hoi-Kei Lon, Ziyi Jin, Nahome Fisseha, Kumar Budur, Michael Gold, Davis Ryman, Hana Florian, Anwar Ahmed, Ikuko Aiba, Alberto Albanese, Kelly Bertram, Yvet
The Lancet Neurology.2021; 20(3): 182. CrossRef - A Study on the Essential and Parkinson’s Arm Tremor Classification
Vasileios Skaramagkas, George Andrikopoulos, Zinovia Kefalopoulou, Panagiotis Polychronopoulos
Signals.2021; 2(2): 201. CrossRef - Progressive Supranuclear Palsy: Improvement in Cognitive-Behavioral Disturbances and Motor-Function Disabilities Following Treatment With Antidepressants and Cholinesterase Inhibitors
Michelle Oyeka, Terngu Ibilah, Jacob Israel, Jose Gavito-Higuera, Ricardo Salazar
Cureus.2021;[Epub] CrossRef - Progressive supranuclear palsy
N.V. Fedorova, E.V. Bril, T.K. Kulua, A.D. Mikhaylova
Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova.2021; 121(5): 111. CrossRef - Best Practices in the Clinical Management of Progressive Supranuclear Palsy and Corticobasal Syndrome: A Consensus Statement of the CurePSP Centers of Care
Brent Bluett, Alexander Y. Pantelyat, Irene Litvan, Farwa Ali, Diana Apetauerova, Danny Bega, Lisa Bloom, James Bower, Adam L. Boxer, Marian L. Dale, Rohit Dhall, Antoine Duquette, Hubert H. Fernandez, Jori E. Fleisher, Murray Grossman, Michael Howell, Di
Frontiers in Neurology.2021;[Epub] CrossRef - The Genetic Landscape of Parkinsonism-Related Dystonias and Atypical Parkinsonism-Related Syndromes
Monica Diez-Fairen, Pilar Alvarez Jerez, Joos Berghausen, Sara Bandres-Ciga
International Journal of Molecular Sciences.2021; 22(15): 8100. CrossRef - MAPT R406W increases tau T217 phosphorylation in absence of amyloid pathology
Chihiro Sato, Nipun Mallipeddi, Nupur Ghoshal, Brenton A. Wright, Gregory S. Day, Albert A. Davis, Albert H. Kim, Gregory J. Zipfel, Randall J. Bateman, Audrey Gabelle, Nicolas R. Barthélemy
Annals of Clinical and Translational Neurology.2021; 8(9): 1817. CrossRef - “Parkinson’s disease” on the way to progressive supranuclear palsy: a review on PSP-parkinsonism
Ján Necpál, Miroslav Borsek, Bibiána Jeleňová
Neurological Sciences.2021; 42(12): 4927. CrossRef - Estimation and discussion of prognosis in neurologic practice. Communication issues with patient with neurological disease
E. V. Bril, A. V. Khasina, F. A. Abbasov, O. S. Zimnyakova, N. V. Fedorova
Medical alphabet.2021; (22): 55. CrossRef - The Progressive Supranuclear Palsy: Past and Present Aspects
Theodore P. Parthimos, Kleopatra H. Schulpis
Clinical Gerontologist.2020; 43(2): 155. CrossRef - Machine Learning Techniques to Identify Dementia
Nivedita Manohar Mathkunti, Shanta Rangaswamy
SN Computer Science.2020;[Epub] CrossRef - My dad and progressive supranuclear palsy (PSP)
Heather Angus-Leppan
Practical Neurology.2020; 20(3): 263. CrossRef - Tauopathy and Movement Disorders—Unveiling the Chameleons and Mimics
Jacky Ganguly, Mandar Jog
Frontiers in Neurology.2020;[Epub] CrossRef - A Home-Based, Music-Cued Movement Program Is Feasible and May Improve Gait in Progressive Supranuclear Palsy
Joanne E. Wittwer, Margaret Winbolt, Meg E. Morris
Frontiers in Neurology.2019;[Epub] CrossRef - Association of autonomic symptoms with disease progression and survival in progressive supranuclear palsy
Marcos C B Oliveira, Helen Ling, Andrew J Lees, Janice L Holton, Eduardo De Pablo-Fernandez, Thomas T Warner
Journal of Neurology, Neurosurgery & Psychiatry.2019; 90(5): 555. CrossRef - Revisiting the diagnostic value of Evans’ index: lessons from an unusual case of normal pressure hydrocephalus with Evans’ index less than 0.3
Jung E. Park, Hyunjin Ju, Kayeong Im, Kyum-Yil Kwon
Neurological Sciences.2019; 40(12): 2637. CrossRef - Progressive supranuclear palsy as differential diagnosis of Parkinson's disease in the elderly
Ricardo Fernández-Ferreira, Raúl Anwar García-Santos, Mayela Rodríguez-Violante, Coral López-Martínez, Ivonne Karina Becerra-Laparra, María Eugenia Torres-Pérez
Revista Española de Geriatría y Gerontología.2019; 54(5): 251. CrossRef - Neuroinflammation as a Common Feature of Neurodegenerative Disorders
Leonardo Guzman-Martinez, Ricardo B. Maccioni, Víctor Andrade, Leonardo Patricio Navarrete, María Gabriela Pastor, Nicolas Ramos-Escobar
Frontiers in Pharmacology.2019;[Epub] CrossRef - On the journey to uncover the causes of selective cellular and regional vulnerability in neurodegeneration
Zane Jaunmuktane, Sebastian Brandner
Acta Neuropathologica.2019; 138(5): 677. CrossRef - Clinical Milestones Preceding the Diagnosis of Multiple System Atrophy and Progressive Supranuclear Palsy: A Retrospective Cohort Study
Louise Wiblin, Rory Durcan, Brook Galna, Mark Lee, David Burn
Journal of Movement Disorders.2019; 12(3): 177. CrossRef - Prediction of the Clinical Severity of Progressive Supranuclear Palsy by Diffusion Tensor Imaging
Yao-Liang Chen, Xiang-An Zhao, Shu-Hang Ng, Chin-Song Lu, Yu-Chun Lin, Jur-Shan Cheng, Chih-Chien Tsai, Jiun-Jie Wang
Journal of Clinical Medicine.2019; 9(1): 40. CrossRef - Tauopathy with hippocampal 4‐repeat tau immunoreactive spherical inclusions: a report of three cases
Gabor G. Kovacs, Linda K. Kwong, Murray Grossman, David J. Irwin, Edward B. Lee, John L. Robinson, Eunran Suh, Vivianna M. Van Deerlin, Virginia M. Lee, John Q. Trojanowski
Brain Pathology.2018; 28(2): 274. CrossRef - A case of spinal anesthesia in a patient with progressive supranuclear palsy
Momoka Tonan, Moritoki Egi, Nana Furushima, Satoshi Mizobuchi
JA Clinical Reports.2018;[Epub] CrossRef - Is it Useful to Classify PSP and CBD as Different Disorders? Yes
Helen Ling, Antonella Macerollo
Movement Disorders Clinical Practice.2018; 5(2): 145. CrossRef - Difficulties in the diagnosis of four repeats (4R) tauopathic parkinsonian syndromes
Piotr Alster, Ewa Krzyżanowska, Dariusz Koziorowski, Stanisław Szlufik, Dorota Różański, Joanna Noskowska, Justyna Mianowicz, Adrian Michno, Leszek Królicki, Andrzej Friedman
Neurologia i Neurochirurgia Polska.2018; 52(4): 459. CrossRef - Neuro-ophthalmology of movement disorders
Olga Waln, Joseph Jankovic
Expert Review of Ophthalmology.2018; 13(5): 283. CrossRef - Role of Neuroimaging on Differentiation of Parkinson’s Disease and Its Related Diseases
Toshihide Ogawa, Shinya Fujii, Keita Kuya, Shin-ichiro Kitao, Yuki Shinohara, Mana Ishibashi, Yoshio Tanabe
Yonago Acta Medica.2018; 61(3): 145. CrossRef - Gait disorders in adults and the elderly
Walter Pirker, Regina Katzenschlager
Wiener klinische Wochenschrift.2017; 129(3-4): 81. CrossRef - Transcranial Magnetic Stimulation for the Assessment of Neurodegenerative Disease
Steve Vucic, Matthew C. Kiernan
Neurotherapeutics.2017; 14(1): 91. CrossRef - Advances in progressive supranuclear palsy: new diagnostic criteria, biomarkers, and therapeutic approaches
Adam L Boxer, Jin-Tai Yu, Lawrence I Golbe, Irene Litvan, Anthony E Lang, Günter U Höglinger
The Lancet Neurology.2017; 16(7): 552. CrossRef
- Existing statistical measures and techniques in detecting and evaluating progressive supranuclear palsy, its phenotypes by using MRI modalities: A Review
- Nonmotor Symptoms and Subthalamic Deep Brain Stimulation in Parkinson’s Disease
- Han-Joon Kim, Beom S. Jeon, Sun Ha Paek
- J Mov Disord. 2015;8(2):83-91. Published online May 31, 2015
- DOI: https://doi.org/10.14802/jmd.15010
- 24,122 View
- 244 Download
- 44 Citations
-
Abstract
PDF
- Subthalamic deep brain stimulation (STN DBS) is an established treatment for the motor symptoms in patients with advanced Parkinson’s disease (PD). In addition to improvements in motor symptoms, many studies have reported changes in various nonmotor symptoms (NMSs) after STN DBS in patients with PD. Psychiatric symptoms, including depression, apathy, anxiety, and impulsivity, can worsen or improve depending on the electrical stimulation parameters, the locations of the stimulating contacts within the STN, and changes in medications after surgery. Global cognitive function is not affected by STN DBS, and there is no increase in the incidence of dementia after STN DBS compared to that after medical treatment, although clinically insignificant declines in verbal fluency have been consistently reported. Pain, especially PD-related pain, improves with STN DBS. Evidence regarding the effects of STN DBS on autonomic symptoms and sleep-related problems is limited and remains conflicting. Many symptoms of nonmotor fluctuations, which are occasionally more troublesome than motor fluctuations, improve with STN DBS. Although it is clear that NMSs are not target symptoms for STN DBS, NMSs have a strong influence on the quality of life of patients with PD, and clinicians should thus be aware of these NMSs when deciding whether to perform surgery and should pay attention to changes in these symptoms after STN DBS to ensure the optimal care for patients.
-
Citations
Citations to this article as recorded by- A Wellness Prescription for Parkinson's: Mid to Late-stage Disease
Gregory M Pontone, Bradley McDaniels, Adrienne M Keener, Indu Subramanian
The American Journal of Geriatric Psychiatry.2023;[Epub] CrossRef - Impact of deep brain stimulation (DBS) on olfaction in Parkinson's disease: Clinical features and functional hypotheses
G. Brand, C. Bontempi, L. Jacquot
Revue Neurologique.2023; 179(9): 947. CrossRef - Time-locked acute alpha-frequency stimulation of subthalamic nuclei during the evaluation of emotional stimuli and its effect on power modulation
Naeem Muhammad, Saurabh Sonkusare, Qiong Ding, Linbin Wang, Alekhya Mandali, Yi Jie Zhao, Bomin Sun, Dianyou Li, Valerie Voon
Frontiers in Human Neuroscience.2023;[Epub] CrossRef - Nutraceuticals a Food for Thought in the Treatment of Parkinson’s
Disease
Keshav Bansal, Sakshi Singh, Vanshita Singh, Meenakshi Bajpai
Current Nutrition & Food Science.2023; 19(9): 961. CrossRef - Subthalamic Nucleus Stimulation in Parkinson's Disease: 5‐Year Extension Study of a Randomized Trial
Silje Bjerknes, Mathias Toft, Reidun Brandt, Trine Waage Rygvold, Ane Konglund, Espen Dietrichs, Stein Andersson, Inger Marie Skogseid
Movement Disorders Clinical Practice.2022; 9(1): 48. CrossRef - Effects of subthalamic deep brain stimulation on non‐motor symptoms of Parkinson's disease: A meta‐analysis
Zahra Eghlidos, Zahra Rahimian, Gholamreza Vadiee, Soodeh Jahangiri
Acta Neurologica Scandinavica.2022; 146(2): 115. CrossRef - Nomogram for Predicting Depression Improvement after Deep Brain Stimulation for Parkinson’s Disease
Bowen Chang, Chen Ni, Jiaming Mei, Chi Xiong, Peng Chen, Manli Jiang, Chaoshi Niu
Brain Sciences.2022; 12(7): 841. CrossRef - A nigra–subthalamic circuit is involved in acute and chronic pain states
Cui Yin, Tao Jia, Yiwen Luan, Xue Zhang, Cheng Xiao, Chunyi Zhou
Pain.2022; 163(10): 1952. CrossRef - A nigro–subthalamo–parabrachial pathway modulates pain-like behaviors
Tao Jia, Ying-Di Wang, Jing Chen, Xue Zhang, Jun-Li Cao, Cheng Xiao, Chunyi Zhou
Nature Communications.2022;[Epub] CrossRef - Basal impulses: findings from the last twenty years on impulsivity and reward pathways using deep brain stimulation
Pavan S. UPADHYAYULA, Robert C. RENNERT, Joel R. MARTIN, John K. YUE, Jason YANG, Eva M. GILLIS-BUCK, Nikki SIDHU, Christopher K. CHEUNG, Anthony T. LEE, Reid R. HOSHIDE, Joseph D. CIACCI
Journal of Neurosurgical Sciences.2021;[Epub] CrossRef - Pallidal versus subthalamic deep-brain stimulation for meige syndrome: a retrospective study
Jiayu Liu, Hu Ding, Ke Xu, Ruen Liu, Dongliang Wang, Jia Ouyang, Zhi Liu, Zeyu Miao
Scientific Reports.2021;[Epub] CrossRef - Eight‐year follow‐up outcome of subthalamic deep brain stimulation for Parkinson’s disease: Maintenance of therapeutic efficacy with a relatively low levodopa dosage and stimulation intensity
Lulu Jiang, Wanru Chen, Qiyu Guo, Chao Yang, Jing Gu, Wenbiao Xian, Yanmei Liu, Yifan Zheng, Jing Ye, Shaohua Xu, Yu Hu, Lei Wu, Jie Chen, Hao Qian, Xiaoli Fu, Jinlong Liu, Ling Chen
CNS Neuroscience & Therapeutics.2021; 27(11): 1366. CrossRef - Clinical Impact of Deep Brain Stimulation on the Autonomic System in Patients with Parkinson's Disease
Gabriele Bellini, Laura A. Best, Una Brechany, Russell Mills, Nicola Pavese
Movement Disorders Clinical Practice.2020; 7(4): 373. CrossRef - Reversal of hyperactive subthalamic circuits differentially mitigates pain hypersensitivity phenotypes in parkinsonian mice
Yiwen Luan, Dongliang Tang, Haichuan Wu, Weixin Gu, Yuqing Wu, Jun-Li Cao, Cheng Xiao, Chunyi Zhou
Proceedings of the National Academy of Sciences.2020; 117(18): 10045. CrossRef - Impulsivity and Compulsivity After Subthalamic Deep Brain Stimulation for Parkinson’s Disease
Sara Scherrer, Andrew H. Smith, Jaimie Gowatsky, Christina A. Palmese, Joohi Jimenez-Shahed, Brian H. Kopell, Helen S. Mayberg, Martijn Figee
Frontiers in Behavioral Neuroscience.2020;[Epub] CrossRef - Deep brain stimulation and recordings: Insights into the contributions of subthalamic nucleus in cognition
Neil M. Drummond, Robert Chen
NeuroImage.2020; 222: 117300. CrossRef - Bilateral Subthalamic Nucleus Deep Brain Stimulation under General Anesthesia: Literature Review and Single Center Experience
Hye Ran Park, Yong Hoon Lim, Eun Jin Song, Jae Meen Lee, Kawngwoo Park, Kwang Hyon Park, Woong-Woo Lee, Han-Joon Kim, Beomseok Jeon, Sun Ha Paek
Journal of Clinical Medicine.2020; 9(9): 3044. CrossRef - Subthalamic deep brain stimulation improves sleep and excessive sweating in Parkinson’s disease
Silje Bjerknes, Inger Marie Skogseid, Tuva Jin Hauge, Espen Dietrichs, Mathias Toft
npj Parkinson's Disease.2020;[Epub] CrossRef - Impacto de la estimulación subtalámica a largo plazo sobre la situación cognitiva de los pacientes con enfermedad de Parkinson avanzada
M. Acera, A. Molano, B. Tijero, G. Bilbao, I. Lambarri, R. Villoria, J. Somme, E. Ruiz de Gopegui, I. Gabilondo, J.C. Gomez-Esteban
Neurología.2019; 34(9): 573. CrossRef - The Subthalamic Nucleus: Unravelling New Roles and Mechanisms in the Control of Action
Tora Bonnevie, Kareem A. Zaghloul
The Neuroscientist.2019; 25(1): 48. CrossRef - Modulation of specific components of sleep disturbances by simultaneous subthalamic and nigral stimulation in Parkinson's disease
U. Hidding, A. Gulberti, C. Pflug, C. Choe, A. Horn, L. Prilop, H. Braaß, O. Fründt, C. Buhmann, D. Weiss, M. Westphal, A.K. Engel, C. Gerloff, J.A. Köppen, W. Hamel, C.K.E. Moll, M. Pötter-Nerger
Parkinsonism & Related Disorders.2019; 62: 141. CrossRef - Zona incerta GABAergic neurons integrate prey-related sensory signals and induce an appetitive drive to promote hunting
Zheng-dong Zhao, Zongming Chen, Xinkuan Xiang, Mengna Hu, Hengchang Xie, Xiaoning Jia, Fang Cai, Yuting Cui, Zijun Chen, Lechen Qian, Jiashu Liu, Congping Shang, Yiqing Yang, Xinyan Ni, Wenzhi Sun, Ji Hu, Peng Cao, Haohong Li, Wei L. Shen
Nature Neuroscience.2019; 22(6): 921. CrossRef - Long-term impact of subthalamic stimulation on cognitive function in patients with advanced Parkinson's disease
M. Acera, A. Molano, B. Tijero, G. Bilbao, I. Lambarri, R. Villoria, J. Somme, E. Ruiz de Gopegui, I. Gabilondo, J.C. Gomez-Esteban
Neurología (English Edition).2019; 34(9): 573. CrossRef - Influencia de la estimulación cerebral profunda en la carga de cuidadores de pacientes con enfermedad de Parkinson
J.A. Crespo-Burillo, D. Rivero-Celada, A. Saenz-de Cabezón, J. Casado-Pellejero, J. Alberdi-Viñas, R. Alarcia-Alejos
Neurología.2018; 33(3): 154. CrossRef - Alteration in the Local and Global Functional Connectivity of Resting State Networks in Parkinson’s Disease
Maryam Ghahremani, Jaejun Yoo, Sun Ju Chung, Kwangsun Yoo, Jong C. Ye, Yong Jeong
Journal of Movement Disorders.2018; 11(1): 13. CrossRef - Deep brain stimulation for patients with Parkinson's disease: Effect on caregiver burden
J.A. Crespo-Burillo, D. Rivero-Celada, A. Saenz-de Cabezón, J. Casado-Pellejero, J. Alberdi-Viñas, R. Alarcia-Alejos
Neurología (English Edition).2018; 33(3): 154. CrossRef - Clinical Markers of Anxiety Subtypes in Parkinson Disease
Martinus P. G. Broen, A. F. G. Leentjens, J. T. Hinkle, A. J. H. Moonen, M. L. Kuijf, N. M. Fischer, K. Perepezko, A. Bakker, G. M. Pontone
Journal of Geriatric Psychiatry and Neurology.2018; 31(2): 55. CrossRef - Apathy following Bilateral Deep Brain Stimulation of Subthalamic Nucleus in Parkinson’s Disease: A Meta-Analysis
Ying Wang, Yongsheng Li, Xiaona Zhang, Anmu Xie
Parkinson's Disease.2018; 2018: 1. CrossRef - Non-motor Characterization of the Basal Ganglia: Evidence From Human and Non-human Primate Electrophysiology
Robert S. Eisinger, Morgan E. Urdaneta, Kelly D. Foote, Michael S. Okun, Aysegul Gunduz
Frontiers in Neuroscience.2018;[Epub] CrossRef - Revealing a novel nociceptive network that links the subthalamic nucleus to pain processing
Arnaud Pautrat, Marta Rolland, Margaux Barthelemy, Christelle Baunez, Valérie Sinniger, Brigitte Piallat, Marc Savasta, Paul G Overton, Olivier David, Veronique Coizet
eLife.2018;[Epub] CrossRef - Cerebrospinal fluid protein markers in PD patients after DBS-STN surgery—A retrospective analysis of patients that underwent surgery between 1993 and 2001
Radu Constantinescu, Kaj Blennow, Lars Rosengren, Barbro Eriksson, Thordis Gudmundsdottir, Yvonne Jansson, Bo Johnels, Annika Renck, Filip Bergquist
Clinical Neurology and Neurosurgery.2018; 174: 174. CrossRef - Predictors to quality of life improvements after subthalamic stimulation in Parkinson’s disease
Feng‐Tao Liu, Li‐Qin Lang, Yu‐Jie Yang, Jue Zhao, Rui Feng, Jie Hu, Jian Wang, Jian‐Jun Wu
Acta Neurologica Scandinavica.2018;[Epub] CrossRef - Apathy associated with neurocognitive disorders: Recent progress and future directions
Krista L. Lanctôt, Luis Agüera‐Ortiz, Henry Brodaty, Paul T. Francis, Yonas E. Geda, Zahinoor Ismail, Gad A. Marshall, Moyra E. Mortby, Chiadi U. Onyike, Prasad R. Padala, Antonios M. Politis, Paul B. Rosenberg, Emma Siegel, David L. Sultzer, Eleenor H. A
Alzheimer's & Dementia.2017; 13(1): 84. CrossRef - Can deep brain stimulation be a therapeutic option for Parkinson's disease dementia?
Han‐Joon Kim, Beomseok Jeon, Jee‐Young Lee, Sun Ha Paek
Neurology and Clinical Neuroscience.2017; 5(1): 3. CrossRef - The effect of deep brain stimulation on the non-motor symptoms of Parkinson’s disease: a critical review of the current evidence
Mónica M Kurtis, Thadshani Rajah, Luisa F Delgado, Haidar S Dafsari
npj Parkinson's Disease.2017;[Epub] CrossRef - Delayed responses of subthalamic nucleus to deep brain stimulation in patients with Parkinson's disease
Lin Shi, Kai Zhang, Fan-Gang Meng, Guan-Yu Zhu, Ying-Chuan Chen, Jun-Jian Zhou, Zhong-Hai Zhou, Jian-Guo Zhang
Parkinsonism & Related Disorders.2017; 40: 76. CrossRef - Acute response of non-motor symptoms to subthalamic deep brain stimulation in Parkinson's disease
Margherita Fabbri, Miguel Coelho, Leonor Correia Guedes, Mario M. Rosa, Daisy Abreu, Nilza Gonçalves, Angelo Antonini, Joaquim J. Ferreira
Parkinsonism & Related Disorders.2017;[Epub] CrossRef - Deep Brain Stimulation of Hemiparkinsonian Rats with Unipolar and Bipolar Electrodes for up to 6 Weeks: Behavioral Testing of Freely Moving Animals
Kathrin Badstuebner, Ulrike Gimsa, Immo Weber, Armin Tuchscherer, Jan Gimsa
Parkinson's Disease.2017; 2017: 1. CrossRef - Current Topics in Deep Brain Stimulation for Parkinson Disease
Atsushi UMEMURA, Genko OYAMA, Yasushi SHIMO, Madoka NAKAJIMA, Asuka NAKAJIMA, Takayuki JO, Satoko SEKIMOTO, Masanobu ITO, Takumi MITSUHASHI, Nobutaka HATTORI, Hajime ARAI
Neurologia medico-chirurgica.2016; 56(10): 613. CrossRef - In Parkinson’s disease STN stimulation enhances responsiveness of movement initiation speed to high reward value
Maja Kojovic, Andrea Higgins, Marjan Jahanshahi
Neuropsychologia.2016; 89: 273. CrossRef - Restoring Spinal Noradrenergic Inhibitory Tone Attenuates Pain Hypersensitivity in a Rat Model of Parkinson’s Disease
Lei-Fang Cao, Xiao-Yan Peng, Ya Huang, Bing Wang, Feng-Ming Zhou, Ruo-Xiao Cheng, Li-Hua Chen, Wei-Feng Luo, Tong Liu
Neural Plasticity.2016; 2016: 1. CrossRef - The KMDS-NATION Study: Korean Movement Disorders Society Multicenter Assessment of Non-Motor Symptoms and Quality of Life in Parkinson's Disease NATION Study Group
Do-Young Kwon, Seong-Beom Koh, Jae Hyeok Lee, Hee Kyung Park, Han-Joon Kim, Hae-Won Shin, Jinyoung Youn, Kun Woo Park, Sun-Ah Choi, Sang Jin Kim, Seong-Min Choi, Ji-Yun Park, Beom S. Jeon, Ji Young Kim, Sun Ju Chung, Chong Sik Lee, Jeong-Ho Park, Tae-Beom
Journal of Clinical Neurology.2016; 12(4): 393. CrossRef - Antiparkinsonian Treatment for Depression in Parkinson's Disease: Are Selective Serotonin Reuptake Inhibitors Recommended?
Philippe De Deurwaerdère, Yuqiang Ding
Translational Neuroscience and Clinics.2016; 2(2): 138. CrossRef - The Subthalamic Nucleus, Limbic Function, and Impulse Control
P. Justin Rossi, Aysegul Gunduz, Michael S. Okun
Neuropsychology Review.2015; 25(4): 398. CrossRef
- A Wellness Prescription for Parkinson's: Mid to Late-stage Disease
- 123I-Metaiodobenzylguanidine Myocardial Scintigraphy in Lewy Body-Related Disorders: A Literature Review
- Eun Joo Chung, Sang Jin Kim
- J Mov Disord. 2015;8(2):55-66. Published online May 31, 2015
- DOI: https://doi.org/10.14802/jmd.15015
- 17,872 View
- 190 Download
- 43 Citations
-
Abstract
PDF
- Lewy body-related disorders are characterized by the presence of Lewy bodies and Lewy neurites, which have abnormal aggregations of α-synuclein in the nigral and extranigral areas, including in the heart. 123I-metaiodobenzylguanidine (MIBG) scintigraphy is a well-known tool to evaluate cardiac sympathetic denervation in the Lewy body-related disorders. MIBG scintigraphy showed low uptake of MIBG in the Lewy body-related disorders, including Parkinson’s disease, dementia with Lewy bodies, pure autonomic failure and rapid eye movement sleep behavior disorder. This review summarizes previous results on the diagnostic applications of MIBG scintigraphy in Lewy body-related disorders.
-
Citations
Citations to this article as recorded by- Sudden cardiac death in synucleinopathies
Keivan Javanshiri, Tove Drakenberg, Mattias Haglund, Elisabet Englund
Journal of Neuropathology & Experimental Neurology.2023; 82(3): 242. CrossRef - Optimal Protocol and Clinical Usefulness of 123I-MIBG Cardiac Scintigraphy for Differentiation of Parkinson’s Disease and Dementia with Lewy Body from Non-Parkinson’s Diseases
In Kook Chun
Nuclear Medicine and Molecular Imaging.2023; 57(3): 145. CrossRef - Cardiac 123I-Metaiodobenzylguanidine (MIBG) Scintigraphy in Parkinson’s Disease: A Comprehensive Review
Jamir Pitton Rissardo, Ana Letícia Fornari Caprara
Brain Sciences.2023; 13(10): 1471. CrossRef - Differentiating Dementia with Lewy Bodies from Alzheimer's Disease Using the Fall Risk Evaluation Questionnaire
Masashi Tsujimoto, Keisuke Suzuki, Akinori Takeda, Naoki Saji, Takashi Sakurai, Yukihiko Washimi
Internal Medicine.2022; 61(11): 1687. CrossRef - Association of plasma α-synuclein with cardiac 123I-MIBG scintigraphy in early Parkinson’s disease
Don Gueu Park, Juhee Kang, Young-Sil An, Jaerak Chang, Jung Han Yoon
Neuroscience Letters.2022; 770: 136399. CrossRef - Clinical and imaging evidence of brain-first and body-first Parkinson's disease
Jacob Horsager, Karoline Knudsen, Michael Sommerauer
Neurobiology of Disease.2022; 164: 105626. CrossRef - Cardiac Alpha-Synuclein Is Present in Alpha-Synucleinopathies
Keivan Javanshiri, Tove Drakenberg, Mattias Haglund, Elisabet Englund
Journal of Parkinson's Disease.2022; 12(4): 1125. CrossRef - Cardiac 123I-MIBG normal uptake values are population-specific: Results from a cohort of controls over 60 years of age
G. Roberts, J. J. Lloyd, J. P. M. Kane, R. Durcan, S. Lawley, K. Howe, G. S. Petrides, J. T. O’Brien, A. J. Thomas
Journal of Nuclear Cardiology.2021; 28(4): 1692. CrossRef - Uniformity of cardiac 123I-MIBG uptake on SPECT images in older adults with normal cognition and patients with dementia
Gemma Roberts, Jim J. Lloyd, Elizabeth Jefferson, Joseph P. M. Kane, Rory Durcan, Sarah Lawley, George S. Petrides, Kim Howe, Iftikhar Haq, John T. O’Brien, Alan J. Thomas
Journal of Nuclear Cardiology.2021; 28(5): 2151. CrossRef - Myocardial Sympathetic Innervation Imaging with MIBG in Dementia with Lewy Bodies
Gagandeep Choudhary, Pradeep Bhambhvani
Journal of Nuclear Cardiology.2021; 28(5): 2164. CrossRef - Identification of BAG2 and Cathepsin D as Plasma Biomarkers for Parkinson’s Disease
Juhee Kang, Jae Whan Kim, Hansol Heo, Jihyun Lee, Kwan Yong Park, Jung Han Yoon, Jaerak Chang
Clinical and Translational Science.2021; 14(2): 606. CrossRef - Gastrointestinal Dysfunction in Parkinson’s Disease
Casper Skjærbæk, Karoline Knudsen, Jacob Horsager, Per Borghammer
Journal of Clinical Medicine.2021; 10(3): 493. CrossRef - Management of Hypertension and Blood Pressure Dysregulation in Patients with Parkinson’s Disease—a Systematic Review
Vasiliki Katsi, Ilias Papakonstantinou, Eirini Solomou, Alexios S. Antonopoulos, Charalambos Vlachopoulos, Konstantinos Tsioufis
Current Hypertension Reports.2021;[Epub] CrossRef - Lewy Body Dementias: A Coin with Two Sides?
Ángela Milán-Tomás, Marta Fernández-Matarrubia, María Cruz Rodríguez-Oroz
Behavioral Sciences.2021; 11(7): 94. CrossRef - Cardiac Autonomic Dysfunction Is Associated with Severity of REM Sleep without Atonia in Isolated REM Sleep Behavior Disorder
Sooyeoun You, Kyoung Sook Won, Keun Tae Kim, Hyang Woon Lee, Yong Won Cho
Journal of Clinical Medicine.2021; 10(22): 5414. CrossRef - A diagnostic strategy for Lewy body disease using DAT-SPECT, MIBG and Combined index
Fumi Sakamoto, Shinya Shiraishi, Koji Ogasawara, Noriko Tsuda, Masataka Nakagawa, Seiji Tomiguchi, Yasuyuki Yamashita
Annals of Nuclear Medicine.2020; 34(6): 415. CrossRef - Difference in cardiovascular response during orthostatic stress in Parkinson’s disease and multiple system atrophy
Tomohiko Nakamura, Masashi Suzuki, Masamichi Ueda, Yumiko Harada, Masaaki Hirayama, Masahisa Katsuno
Journal of Neural Transmission.2020; 127(10): 1377. CrossRef - Striatal dopamine activity and myocardial 123I-metaiodobenzylguanidine uptake in early Parkinson's disease
Yoon-Sang Oh, Joong-Seok Kim, Sang-Won Yoo, Eo-Jin Hwang, Chul Hyoung Lyoo, Kwang-Soo Lee
Parkinsonism & Related Disorders.2019; 63: 156. CrossRef - Initial Versus Follow-up Sequential Myocardial 123I-MIBG Scintigraphy to Discriminate Parkinson Disease From Atypical Parkinsonian Syndromes
Dong-Woo Ryu, Joong-Seok Kim, Jee-Eun Lee, Yoon-Sang Oh, Sang-Won Yoo, Ie Ryung Yoo, Kwang-Soo Lee
Clinical Nuclear Medicine.2019; 44(4): 282. CrossRef - Cardiac 123I-MIBG planar heart to mediastinum ratios depend on patient size; phantom studies suggest SPECT-CT could improve quantification
Gemma Roberts, Jim J Lloyd, George S Petrides, John T O’Brien, Alan J Thomas
Biomedical Physics & Engineering Express.2019; 6(1): 015011. CrossRef - Does sympathetic dysfunction occur before denervation in pure autonomic failure?
Ling Guo, Murray D. Esler, Carolina Sari, Sarah Phillips, Elisabeth A. Lambert, Nora E. Straznicky, Gavin W. Lambert, Susan J. Corcoran
Clinical Science.2018; 132(1): 1. CrossRef - Validation of Iodine-131-meta-iodobenzylguanidine cardiac scintigraphy in Parkinsonism: A preliminary study
Dan Xu, Wenjia Zhu, Li Huo, Shikun Zhu, Fang Li, Han Wang
Parkinsonism & Related Disorders.2018;[Epub] CrossRef - Extensive Delayed Brain Atrophy after Resuscitation in a Patient with Multiple System Atrophy
Sazuku Nisitani, Hirofumi Miyoshi, Yoji Katsuoka
Frontiers in Neurology.2018;[Epub] CrossRef - Optimizing Parkinson’s disease diagnosis: the role of a dual nuclear imaging algorithm
J. William Langston, Jesse C. Wiley, Michele Tagliati
npj Parkinson's Disease.2018;[Epub] CrossRef - Diagnostic biomarkers for Parkinson’s disease at a glance: where are we?
Ilaria Cova, Alberto Priori
Journal of Neural Transmission.2018; 125(10): 1417. CrossRef - Imaging the Autonomic Nervous System in Parkinson’s Disease
Karoline Knudsen, Per Borghammer
Current Neurology and Neuroscience Reports.2018;[Epub] CrossRef - A Review of Dementia with Lewy Bodies' Impact, Diagnostic Criteria and Treatment
Samuel D. Capouch, Martin R. Farlow, Jared R. Brosch
Neurology and Therapy.2018; 7(2): 249. CrossRef - The Utility of the Combined Use of 123I-FP-CIT and 123I-MIBG Myocardial Scintigraphy in Differentiating Parkinson’s Disease from Other Parkinsonian Syndromes
Eiji Matsusue, Yoshio Fujihara, Kenichiro Tanaka, Yuki Aozasa, Manabu Shimoda, Hiroyuki Nakayasu, Kazuhiko Nakamura, Toshihide Ogawa
Yonago Acta Medica.2018; 61(2): 117. CrossRef - Correction of collimator-dependent differences in the heart-to-mediastinum ratio in 123I-metaiodobenzylguanidine cardiac sympathetic imaging: Determination of conversion equations using point-source imaging
Yusuke Inoue, Yutaka Abe, Kei Kikuchi, Keiji Matsunaga, Ray Masuda, Kazutoshi Nishiyama
Journal of Nuclear Cardiology.2017; 24(5): 1725. CrossRef - Normal ‘heart’ in Parkinson's disease: is this a distinct clinical phenotype?
J.‐S. Kim, H.‐E. Park, I.‐S. Park, Y.‐S. Oh, D.‐W. Ryu, I.‐U. Song, Y.‐A. Jung, I. R. Yoo, H.‐S. Choi, P. H. Lee, K.‐S. Lee
European Journal of Neurology.2017; 24(2): 349. CrossRef - Diagnosis of dementia with Lewy bodies: can123I-IMP and123I-MIBG scintigraphy yield new core features?
Fumi Sakamoto, Shinya Shiraishi, Noriko Tsuda, Mamoru Hashimoto, Seiji Tomiguchi, Manabu Ikeda, Yasuyuki Yamashita
The British Journal of Radiology.2017; 90(1070): 20160156. CrossRef - Imaging Parkinson’s disease below the neck
Per Borghammer, Karoline Knudsen, Tatyana D. Fedorova, David J. Brooks
npj Parkinson's Disease.2017;[Epub] CrossRef - The utility of the combination of a SPECT study with [123I]-FP-CIT of dopamine transporters and [123I]-MIBG myocardial scintigraphy in differentiating Parkinson disease from other degenerative parkinsonian syndromes
Naoto Uyama, Hideki Otsuka, Takayoshi Shinya, Yoichi Otomi, Masafumi Harada, Wataru Sako, Yuishin Izumi, Ryuji Kaji, Yuya Watanabe, Satoru Takashi, Yamato Kunikane
Nuclear Medicine Communications.2017; 38(6): 487. CrossRef - Cardiac sympathetic denervation and dementia in de novo Parkinson's disease: A 7-year follow-up study
Mun Hee Choi, Jung Han Yoon, Suk Woo Yong
Journal of the Neurological Sciences.2017; 381: 291. CrossRef - Cardiovascular autonomic dysfunctions in elderly patients with essential tremor: comparison with healthy controls
Joong-Seok Kim, Yoon-Sang Oh, Hyung-Eun Park, Si-Hoon Lee, Jeong-Wook Park, In-Uk Song, Jae-Young An, Hun-Jun Park, Byung-Chul Son, Kwang-Soo Lee
Neurological Sciences.2016; 37(5): 711. CrossRef - Orthostatic hypotension and cardiac sympathetic denervation in Parkinson disease patients with REM sleep behavioral disorder
Joong-Seok Kim, Hyung-Eun Park, Yoon-Sang Oh, Si-Hoon Lee, Jeong-Wook Park, Byung-chul Son, Kwang-Soo Lee
Journal of the Neurological Sciences.2016; 362: 59. CrossRef - [123]FP-CIT SPECT scans initially rated as normal became abnormal over time in patients with probable dementia with Lewy bodies
J. J. van der Zande, J. Booij, P. Scheltens, P. G. H. M. Raijmakers, A. W. Lemstra
European Journal of Nuclear Medicine and Molecular Imaging.2016; 43(6): 1060. CrossRef - Is dopamine transporter invariably impaired at the time of diagnosis in dementia with Lewy bodies?
Flavio Nobili, Dario Arnaldi, Silvia Morbelli
European Journal of Nuclear Medicine and Molecular Imaging.2016; 43(6): 1056. CrossRef - Imaging Systemic Dysfunction in Parkinson’s Disease
Per Borghammer, Karoline Knudsen, David J. Brooks
Current Neurology and Neuroscience Reports.2016;[Epub] CrossRef - 123I‐2β‐carbomethoxy‐3β‐(4‐iodophenyl)‐N‐(3‐fluoropropyl) nortropane single photon emission computed tomography and 123I‐metaiodobenzylguanidine myocardial scintigraphy in differentiating dementia with lewy bodies from other dementias: A comparative study
Pietro Tiraboschi, Angelo Corso, Ugo Paolo Guerra, Flavio Nobili, Arnoldo Piccardo, Maria Lucia Calcagni, Duccio Volterrani, Diego Cecchin, Mauro Tettamanti, Luigi Antelmi, Simone Vidale, Leonardo Sacco, Maria Merello, Stefano Stefanini, Anna Micheli, Pao
Annals of Neurology.2016; 80(3): 368. CrossRef - On the Utility of MIBG SPECT/CT in Evaluating Cardiac Sympathetic Dysfunction in Lewy Body Diseases
Hayato Odagiri, Toru Baba, Yoshiyuki Nishio, Osamu Iizuka, Minoru Matsuda, Kentaro Inoue, Akio Kikuchi, Takafumi Hasegawa, Masashi Aoki, Atsushi Takeda, Yasuyuki Taki, Etsuro Mori, John Duda
PLOS ONE.2016; 11(4): e0152746. CrossRef - 123I-MIBG myocardial scintigraphy and neurocirculatory abnormalities in patients with dementia with Lewy bodies and Alzheimer's disease
Joong-Seok Kim, Hyung-Eun Park, Yoon-Sang Oh, In-Uk Song, Dong-Won Yang, Jeong-Wook Park, Kwang-Soo Lee
Journal of the Neurological Sciences.2015; 357(1-2): 173. CrossRef - Orthostatic hypotension: managing a difficult problem
Pearl K Jones, Brett H Shaw, Satish R Raj
Expert Review of Cardiovascular Therapy.2015; 13(11): 1263. CrossRef
- Sudden cardiac death in synucleinopathies
First
Prev
