Skip Navigation
Skip to contents

JMD : Journal of Movement Disorders

OPEN ACCESS
SEARCH
Search

Previous issues

Page Path
HOME > Browse Articles > Previous issues
10 Previous issues
Filter
Filter
Article category
Keywords
Authors
Funded articles
Volume 9(1); January 2016
Prev issue Next issue
Editorial
Missions of Journal of Movement Disorders
Yun Joong Kim
J Mov Disord. 2016;9(1):1-2.   Published online January 25, 2016
DOI: https://doi.org/10.14802/jmd.15063
  • 12,904 View
  • 95 Download
PDF
Review Articles
Article image
Clinical Approach to Progressive Supranuclear Palsy
Helen Ling
J Mov Disord. 2016;9(1):3-13.   Published online January 25, 2016
DOI: https://doi.org/10.14802/jmd.15060
  • 36,259 View
  • 1,318 Download
  • 51 Web of Science
  • 48 Crossref
AbstractAbstract PDF
Sixty years ago, Steele, Richardson and Olszewski designated progressive supranuclear palsy (PSP) as a new clinicopathological entity in their seminal paper. Since then, in addition to the classic Richardson’s syndrome (RS), different clinical phenotypic presentations have been linked with this four-repeat tauopathy. The clinical heterogeneity is associated with variability of regional distribution and severity of abnormal tau accumulation and neuronal loss. In PSP subtypes, the presence of certain clinical pointers may be useful for antemortem prediction of the underlying PSP-tau pathology. Midbrain atrophy on conventional MRI correlates with the clinical phenotype of RS but is not predictive of PSP pathology. Cerebrospinal fluid biomarkers and tau ligand positron emission tomography are promising biomarkers of PSP. A multidisciplinary approach to meet the patients’ complex needs is the current core treatment strategy for this devastating disorder.

Citations

Citations to this article as recorded by  
  • PSP-Richardson syndrome mimics: An overview and pragmatic approach
    J. Necpál, M. Borsek, B. Jeleňová
    Revue Neurologique.2024; 180(1-2): 12.     CrossRef
  • Mechanisms linking cerebrovascular dysfunction and tauopathy: Adding a layer of epiregulatory complexity
    Yoon A. Kim, Marian Mellen, Caghan Kizil, Ismael Santa‐Maria
    British Journal of Pharmacology.2024; 181(6): 879.     CrossRef
  • Concomitant Medications for Progressive Supranuclear Palsy
    Jay M. Iyer, Douglas Gunzler, Anthony E. Lang, Lawrence I. Golbe, Alexander Pantelyat, Adam L. Boxer, Anne-Marie Wills
    JAMA Neurology.2024; 81(3): 295.     CrossRef
  • SEND-PD in Parkinsonian Syndromes: Results of a Monocentric Cross-Sectional Study
    Linda Veith Sanches, Stephan Greten, Johanna Doll-Lee, Sophia Rogozinski, Johanne Heine, Lea Krey, Sarana Ulaganathan, Ida Jensen, Matthias Höllerhage, Sam Sani, Günter Höglinger, Florian Wegner, Martin Klietz
    Neuropsychiatric Disease and Treatment.2024; Volume 20: 1849.     CrossRef
  • Existing statistical measures and techniques in detecting and evaluating progressive supranuclear palsy, its phenotypes by using MRI modalities: A Review
    Nirmal Adam Sait, J Kathirvelan
    Materials Today: Proceedings.2023; 80: 2000.     CrossRef
  • The role of magnetic resonance imaging in the diff erential diagnosis of Parkinson’s disease
    A. A. Tappakhov, T. E. Popova
    Russian neurological journal.2023; 28(1): 5.     CrossRef
  • Clinical features of progressive supranuclear palsy
    Yafei Wen, Qijie Yang, Bin Jiao, Weiwei Zhang, Jingyi Lin, Yuan Zhu, Qian Xu, Hui Zhou, Ling Weng, Xinxin Liao, Yafang Zhou, Junling Wang, Jifeng Guo, Xinxiang Yan, Hong Jiang, Beisha Tang, Lu Shen
    Frontiers in Aging Neuroscience.2023;[Epub]     CrossRef
  • Midbrain area and the hummingbird sign from brain MRI in progressive supranuclear palsy and idiopathic normal pressure hydrocephalus
    Johan Virhammar, Harald Blohmé, Dag Nyholm, Charalampos Georgiopoulos, David Fällmar
    Journal of Neuroimaging.2022; 32(1): 90.     CrossRef
  • Cognitive, Psychiatric, and Motor Symptoms–Based Algorithmic Approach to Differentiate Among Various Types of Dementia Syndromes
    Rehab Magdy, Mona Hussein
    Journal of Nervous & Mental Disease.2022; 210(2): 129.     CrossRef
  • Idiopathic normal pressure hydrocephalus-like MRI features in patients with progressive supranuclear palsy: a comparative case-control study
    Halil Onder, Bilge Kocer, Selcuk Comoglu
    Neurological Research.2022; 44(9): 807.     CrossRef
  • Targeting alpha-synuclein or tau for treating neurodegenerative movement disorders
    M. Lopez-Cuina, W.G. Meissner
    Revue Neurologique.2022; 178(5): 460.     CrossRef
  • Clinical Aspects of the Differential Diagnosis of Parkinson’s Disease and Parkinsonism
    Hae-Won Shin, Sang-Wook Hong, Young Chul Youn
    Journal of Clinical Neurology.2022; 18(3): 259.     CrossRef
  • Dopamine transporter imaging in progressive supranuclear palsy: Severe but nonspecific to subtypes
    Qi‐Si Chen, Xin‐Yi Li, Ling Li, Jia‐Ying Lu, Yi‐Min Sun, Feng‐Tao Liu, Chuan‐Tao Zuo, Jian Wang
    Acta Neurologica Scandinavica.2022; 146(3): 237.     CrossRef
  • CSF tau microtubule-binding region identifies pathological changes in primary tauopathies
    Kanta Horie, Nicolas R. Barthélemy, Salvatore Spina, Lawren VandeVrede, Yingxin He, Ross W. Paterson, Brenton A. Wright, Gregory S. Day, Albert A. Davis, Celeste M. Karch, William W. Seeley, Richard J. Perrin, Rama K. Koppisetti, Faris Shaikh, Argentina L
    Nature Medicine.2022; 28(12): 2547.     CrossRef
  • Role of Multivoxel MR Spectroscopy Progressive Supranuclear Palsy – A Preliminary Study
    Sandhya Mangalore, Manoj Kumar, Pramod Pal, Jitender Saini, Shaik Pasha, Ravi Yadav
    Neurology India.2022; 70(6): 2388.     CrossRef
  • Genetics of Progressive Supranuclear Palsy: A Review
    Yafei Wen, Yafang Zhou, Bin Jiao, Lu Shen
    Journal of Parkinson's Disease.2021; 11(1): 93.     CrossRef
  • Disease course and treatment patterns in progressive supranuclear palsy: A real-world study
    John C. Morgan, Xiaolan Ye, Jennifer A. Mellor, Keisha J. Golden, Jorge Zamudio, Louis A. Chiodo, Yanjun Bao, Tao Xie
    Journal of the Neurological Sciences.2021; 421: 117293.     CrossRef
  • Central nystagmus in progressive supranuclear palsy: A neglected clinical feature?
    Maja Klarendic, Manja Hribar, Nina Bozanic Urbancic, Nina Zupancic, Milica G. Kramberger, Maja Trost, Saba Battelino, Diego Kaski, Maja Kojovic
    Parkinsonism & Related Disorders.2021; 84: 15.     CrossRef
  • Safety and efficacy of tilavonemab in progressive supranuclear palsy: a phase 2, randomised, placebo-controlled trial
    Günter U Höglinger, Irene Litvan, Nuno Mendonca, Deli Wang, Hui Zheng, Beatrice Rendenbach-Mueller, Hoi-Kei Lon, Ziyi Jin, Nahome Fisseha, Kumar Budur, Michael Gold, Davis Ryman, Hana Florian, Anwar Ahmed, Ikuko Aiba, Alberto Albanese, Kelly Bertram, Yvet
    The Lancet Neurology.2021; 20(3): 182.     CrossRef
  • A Study on the Essential and Parkinson’s Arm Tremor Classification
    Vasileios Skaramagkas, George Andrikopoulos, Zinovia Kefalopoulou, Panagiotis Polychronopoulos
    Signals.2021; 2(2): 201.     CrossRef
  • Progressive Supranuclear Palsy: Improvement in Cognitive-Behavioral Disturbances and Motor-Function Disabilities Following Treatment With Antidepressants and Cholinesterase Inhibitors
    Michelle Oyeka, Terngu Ibilah, Jacob Israel, Jose Gavito-Higuera, Ricardo Salazar
    Cureus.2021;[Epub]     CrossRef
  • Progressive supranuclear palsy
    N.V. Fedorova, E.V. Bril, T.K. Kulua, A.D. Mikhaylova
    Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova.2021; 121(5): 111.     CrossRef
  • Best Practices in the Clinical Management of Progressive Supranuclear Palsy and Corticobasal Syndrome: A Consensus Statement of the CurePSP Centers of Care
    Brent Bluett, Alexander Y. Pantelyat, Irene Litvan, Farwa Ali, Diana Apetauerova, Danny Bega, Lisa Bloom, James Bower, Adam L. Boxer, Marian L. Dale, Rohit Dhall, Antoine Duquette, Hubert H. Fernandez, Jori E. Fleisher, Murray Grossman, Michael Howell, Di
    Frontiers in Neurology.2021;[Epub]     CrossRef
  • The Genetic Landscape of Parkinsonism-Related Dystonias and Atypical Parkinsonism-Related Syndromes
    Monica Diez-Fairen, Pilar Alvarez Jerez, Joos Berghausen, Sara Bandres-Ciga
    International Journal of Molecular Sciences.2021; 22(15): 8100.     CrossRef
  • MAPT R406W increases tau T217 phosphorylation in absence of amyloid pathology
    Chihiro Sato, Nipun Mallipeddi, Nupur Ghoshal, Brenton A. Wright, Gregory S. Day, Albert A. Davis, Albert H. Kim, Gregory J. Zipfel, Randall J. Bateman, Audrey Gabelle, Nicolas R. Barthélemy
    Annals of Clinical and Translational Neurology.2021; 8(9): 1817.     CrossRef
  • “Parkinson’s disease” on the way to progressive supranuclear palsy: a review on PSP-parkinsonism
    Ján Necpál, Miroslav Borsek, Bibiána Jeleňová
    Neurological Sciences.2021; 42(12): 4927.     CrossRef
  • Estimation and discussion of prognosis in neurologic practice. Communication issues with patient with neurological disease
    E. V. Bril, A. V. Khasina, F. A. Abbasov, O. S. Zimnyakova, N. V. Fedorova
    Medical alphabet.2021; (22): 55.     CrossRef
  • The Progressive Supranuclear Palsy: Past and Present Aspects
    Theodore P. Parthimos, Kleopatra H. Schulpis
    Clinical Gerontologist.2020; 43(2): 155.     CrossRef
  • Machine Learning Techniques to Identify Dementia
    Nivedita Manohar Mathkunti, Shanta Rangaswamy
    SN Computer Science.2020;[Epub]     CrossRef
  • My dad and progressive supranuclear palsy (PSP)
    Heather Angus-Leppan
    Practical Neurology.2020; 20(3): 263.     CrossRef
  • Tauopathy and Movement Disorders—Unveiling the Chameleons and Mimics
    Jacky Ganguly, Mandar Jog
    Frontiers in Neurology.2020;[Epub]     CrossRef
  • A Home-Based, Music-Cued Movement Program Is Feasible and May Improve Gait in Progressive Supranuclear Palsy
    Joanne E. Wittwer, Margaret Winbolt, Meg E. Morris
    Frontiers in Neurology.2019;[Epub]     CrossRef
  • Association of autonomic symptoms with disease progression and survival in progressive supranuclear palsy
    Marcos C B Oliveira, Helen Ling, Andrew J Lees, Janice L Holton, Eduardo De Pablo-Fernandez, Thomas T Warner
    Journal of Neurology, Neurosurgery & Psychiatry.2019; 90(5): 555.     CrossRef
  • Revisiting the diagnostic value of Evans’ index: lessons from an unusual case of normal pressure hydrocephalus with Evans’ index less than 0.3
    Jung E. Park, Hyunjin Ju, Kayeong Im, Kyum-Yil Kwon
    Neurological Sciences.2019; 40(12): 2637.     CrossRef
  • Progressive supranuclear palsy as differential diagnosis of Parkinson's disease in the elderly
    Ricardo Fernández-Ferreira, Raúl Anwar García-Santos, Mayela Rodríguez-Violante, Coral López-Martínez, Ivonne Karina Becerra-Laparra, María Eugenia Torres-Pérez
    Revista Española de Geriatría y Gerontología.2019; 54(5): 251.     CrossRef
  • Neuroinflammation as a Common Feature of Neurodegenerative Disorders
    Leonardo Guzman-Martinez, Ricardo B. Maccioni, Víctor Andrade, Leonardo Patricio Navarrete, María Gabriela Pastor, Nicolas Ramos-Escobar
    Frontiers in Pharmacology.2019;[Epub]     CrossRef
  • On the journey to uncover the causes of selective cellular and regional vulnerability in neurodegeneration
    Zane Jaunmuktane, Sebastian Brandner
    Acta Neuropathologica.2019; 138(5): 677.     CrossRef
  • Clinical Milestones Preceding the Diagnosis of Multiple System Atrophy and Progressive Supranuclear Palsy: A Retrospective Cohort Study
    Louise Wiblin, Rory Durcan, Brook Galna, Mark Lee, David Burn
    Journal of Movement Disorders.2019; 12(3): 177.     CrossRef
  • Prediction of the Clinical Severity of Progressive Supranuclear Palsy by Diffusion Tensor Imaging
    Yao-Liang Chen, Xiang-An Zhao, Shu-Hang Ng, Chin-Song Lu, Yu-Chun Lin, Jur-Shan Cheng, Chih-Chien Tsai, Jiun-Jie Wang
    Journal of Clinical Medicine.2019; 9(1): 40.     CrossRef
  • Tauopathy with hippocampal 4‐repeat tau immunoreactive spherical inclusions: a report of three cases
    Gabor G. Kovacs, Linda K. Kwong, Murray Grossman, David J. Irwin, Edward B. Lee, John L. Robinson, Eunran Suh, Vivianna M. Van Deerlin, Virginia M. Lee, John Q. Trojanowski
    Brain Pathology.2018; 28(2): 274.     CrossRef
  • A case of spinal anesthesia in a patient with progressive supranuclear palsy
    Momoka Tonan, Moritoki Egi, Nana Furushima, Satoshi Mizobuchi
    JA Clinical Reports.2018;[Epub]     CrossRef
  • Is it Useful to Classify PSP and CBD as Different Disorders? Yes
    Helen Ling, Antonella Macerollo
    Movement Disorders Clinical Practice.2018; 5(2): 145.     CrossRef
  • Difficulties in the diagnosis of four repeats (4R) tauopathic parkinsonian syndromes
    Piotr Alster, Ewa Krzyżanowska, Dariusz Koziorowski, Stanisław Szlufik, Dorota Różański, Joanna Noskowska, Justyna Mianowicz, Adrian Michno, Leszek Królicki, Andrzej Friedman
    Neurologia i Neurochirurgia Polska.2018; 52(4): 459.     CrossRef
  • Neuro-ophthalmology of movement disorders
    Olga Waln, Joseph Jankovic
    Expert Review of Ophthalmology.2018; 13(5): 283.     CrossRef
  • Role of Neuroimaging on Differentiation of Parkinson’s Disease and Its Related Diseases
    Toshihide Ogawa, Shinya Fujii, Keita Kuya, Shin-ichiro Kitao, Yuki Shinohara, Mana Ishibashi, Yoshio Tanabe
    Yonago Acta Medica.2018; 61(3): 145.     CrossRef
  • Gait disorders in adults and the elderly
    Walter Pirker, Regina Katzenschlager
    Wiener klinische Wochenschrift.2017; 129(3-4): 81.     CrossRef
  • Transcranial Magnetic Stimulation for the Assessment of Neurodegenerative Disease
    Steve Vucic, Matthew C. Kiernan
    Neurotherapeutics.2017; 14(1): 91.     CrossRef
  • Advances in progressive supranuclear palsy: new diagnostic criteria, biomarkers, and therapeutic approaches
    Adam L Boxer, Jin-Tai Yu, Lawrence I Golbe, Irene Litvan, Anthony E Lang, Günter U Höglinger
    The Lancet Neurology.2017; 16(7): 552.     CrossRef
Article image
Mechanism of Anti-α-Synuclein Immunotherapy
Jun Sung Lee, Seung-Jae Lee
J Mov Disord. 2016;9(1):14-19.   Published online January 25, 2016
DOI: https://doi.org/10.14802/jmd.15059
  • 26,282 View
  • 344 Download
  • 37 Web of Science
  • 37 Crossref
AbstractAbstract PDF
Immunization therapy targeting α-synuclein has emerged as a promising approach for Parkinson’s disease and perhaps for other synucleinopathies. Several antibodies have shown therapeutic effects in mouse models of synucleinopathies and have alleviated the pathological and behavioral phenotypes of these mice. The mechanisms through which the immunization therapy works were initially puzzling, especially given that α-synuclein is a typical cytosolic protein. Recent studies, however, suggested that extracellular α-synuclein is an important pathogenic entity, and hence, a target for immunotherapy. Here, we review the literature describing immunization therapy for synucleinopathies in mouse models and provide current thoughts on the potential mechanisms underlying the therapeutic effects of α-synuclein immunotherapy.

Citations

Citations to this article as recorded by  
  • Aggregation-Induced Emission Luminogens: A New Possibility for Efficient Visualization of RNA in Plants
    Zheng-Chao Yang, Li-Xiang Zhao, Yu-Qi Sang, Xin Huang, Xuan-Chen Lin, Zhi-Ming Yu
    Plants.2024; 13(5): 743.     CrossRef
  • Oxidative Stress and Dopaminergic Metabolism: A Major PD Pathogenic Mechanism and Basis of Potential Antioxidant Therapies
    Aamir Rasool, Robina Manzoor, Kaleem Ullah, Ramsha Afzal, Asad Ul-Haq, Hadia Imran, Imdad Kaleem, Tanveer Akhtar, Anum Farrukh, Sahir Hameed, Shahid Bashir
    CNS & Neurological Disorders - Drug Targets.2024; 23(7): 852.     CrossRef
  • Effectiveness of Flavonoid-Rich Diet in Alleviating Symptoms of Neurodegenerative Diseases
    Aneta Szulc, Karolina Wiśniewska, Magdalena Żabińska, Lidia Gaffke, Maria Szota, Zuzanna Olendzka, Grzegorz Węgrzyn, Karolina Pierzynowska
    Foods.2024; 13(12): 1931.     CrossRef
  • Immunisation with UB-312 in the Thy1SNCA mouse prevents motor performance deficits and oligomeric α-synuclein accumulation in the brain and gut
    Jacqui T. Nimmo, Harry Smith, Chang Yi Wang, Jessica L. Teeling, James A. R. Nicoll, Ajay Verma, Jean-Cosme Dodart, Zhi Liu, Feng Lin, Roxana O. Carare
    Acta Neuropathologica.2022; 143(1): 55.     CrossRef
  • Autophagy-Related Pathways in Vesicular Unconventional Protein Secretion
    Shin Hye Noh, Ye Jin Kim, Min Goo Lee
    Frontiers in Cell and Developmental Biology.2022;[Epub]     CrossRef
  • Targeting Macroautophagy as a Therapeutic Opportunity to Treat Parkinson’s Disease
    Irene Sanchez-Mirasierra, Saurav Ghimire, Sergio Hernandez-Diaz, Sandra-Fausia Soukup
    Frontiers in Cell and Developmental Biology.2022;[Epub]     CrossRef
  • A quantitative systems pharmacology model for simulating OFF-Time in augmentation trials for Parkinson’s disease: application to preladenant
    Rachel Rose, Emma Mitchell, Piet Van Der Graaf, Daisuke Takaichi, Jun Hosogi, Hugo Geerts
    Journal of Pharmacokinetics and Pharmacodynamics.2022; 49(6): 593.     CrossRef
  • Neuroimmune crosstalk and evolving pharmacotherapies in neurodegenerative diseases
    Falguni Baidya, Mariya Bohra, Aishika Datta, Deepaneeta Sarmah, Birva Shah, Priya Jagtap, Swapnil Raut, Ankan Sarkar, Upasna Singh, Kiran Kalia, Anupom Borah, Xin Wang, Kunjan R. Dave, Dileep R. Yavagal, Pallab Bhattacharya
    Immunology.2021; 162(2): 160.     CrossRef
  • Electrogastrography for diagnosis of early-stage Parkinson's disease
    Nobuyuki Araki, Yoshitaka Yamanaka, Anupama Poudel, Yoshikatsu Fujinuma, Akira Katagiri, Satoshi Kuwabara, Masato Asahina
    Parkinsonism & Related Disorders.2021; 86: 61.     CrossRef
  • Natural Alkaloid Compounds as Inhibitors for Alpha-Synuclein Seeded Fibril Formation and Toxicity
    Simona S. Ghanem, Hend S. Fayed, Qi Zhu, Jia-Hong Lu, Nishant N. Vaikath, Janarthanan Ponraj, Said Mansour, Omar M. A. El-Agnaf
    Molecules.2021; 26(12): 3736.     CrossRef
  • Tat-p27 Ameliorates Neuronal Damage Reducing α-Synuclein and Inflammatory Responses in Motor Neurons After Spinal Cord Ischemia
    Woosuk Kim, Hyun Jung Kwon, Hyo Young Jung, Kyu Ri Hahn, Seung Myung Moon, Yeo Sung Yoon, In Koo Hwang, Soo Young Choi, Dae Won Kim
    Neurochemical Research.2021; 46(12): 3123.     CrossRef
  • Immunotherapies for Parkinson’s Disease: Progression of Clinical Development
    Jet Shee Teng, Yin Yin Ooi, Soi Moi Chye, Anna Pick Kiong Ling, Rhun Yian Koh
    CNS & Neurological Disorders - Drug Targets.2021; 20(9): 802.     CrossRef
  • Parkinson Disease: Translating Insights from Molecular Mechanisms to Neuroprotection
    Sheila K. Pirooznia, Liana S. Rosenthal, Valina L. Dawson, Ted M. Dawson, Eric Barker
    Pharmacological Reviews.2021; 73(4): 1204.     CrossRef
  • Anti-inflammatory and Neuroprotective Agents in Clinical Trials for CNS Disease and Injury: Where Do We Go From Here?
    Khalil Mallah, Christine Couch, Davis M. Borucki, Amer Toutonji, Mohammed Alshareef, Stephen Tomlinson
    Frontiers in Immunology.2020;[Epub]     CrossRef
  • Targeting α-synuclein by PD03 AFFITOPE® and Anle138b rescues neurodegenerative pathology in a model of multiple system atrophy: clinical relevance
    Miguel Lemos, Serena Venezia, Violetta Refolo, Antonio Heras-Garvin, Sabine Schmidhuber, Armin Giese, Andrei Leonov, Sergey Ryazanov, Christian Griesinger, Gergana Galabova, Guenther Staffler, Gregor Karl Wenning, Nadia Stefanova
    Translational Neurodegeneration.2020;[Epub]     CrossRef
  • Insights Into Peptide Inhibition of Alpha-Synuclein Aggregation
    James H. Torpey, Richard M. Meade, Ravina Mistry, Jody M. Mason, Jillian Madine
    Frontiers in Neuroscience.2020;[Epub]     CrossRef
  • Novel antibodies detect additional α-synuclein pathology in synucleinopathies: potential development for immunotherapy
    Jacqui T. Nimmo, Ajay Verma, Jean-Cosme Dodart, Chang Yi Wang, Jimmy Savistchenko, Ronald Melki, Roxana O. Carare, James A. R. Nicoll
    Alzheimer's Research & Therapy.2020;[Epub]     CrossRef
  • Cellular and Molecular Aspects of Parkinson Treatment: Future Therapeutic Perspectives
    Khosro Jamebozorgi, Eskandar Taghizadeh, Daryoush Rostami, Hosein Pormasoumi, George E. Barreto, Seyed Mohammad Gheibi Hayat, Amirhossein Sahebkar
    Molecular Neurobiology.2019; 56(7): 4799.     CrossRef
  • The Associations between Immunological Reactivity to the Haptenation of Unconjugated Bisphenol A to Albumin and Protein Disulfide Isomerase with Alpha-Synuclein Antibodies
    Datis Kharrazian, Martha Herbert, Aristo Vojdani
    Toxics.2019; 7(2): 26.     CrossRef
  • Effects of single and combined immunotherapy approach targeting amyloid β protein and α‐synuclein in a dementia with Lewy bodies–like model
    Markus Mandler, Edward Rockenstein, Cassia Overk, Michael Mante, Jazmin Florio, Anthony Adame, Changyoun Kim, Radmila Santic, Achim Schneeberger, Frank Mattner, Sabine Schmidhuber, Gergana Galabova, Brian Spencer, Eliezer Masliah, Robert A. Rissman
    Alzheimer's & Dementia.2019; 15(9): 1133.     CrossRef
  • Translational therapies for multiple system atrophy: Bottlenecks and future directions
    Nadia Stefanova
    Autonomic Neuroscience.2018; 211: 7.     CrossRef
  • Integrin CD11b mediates α-synuclein-induced activation of NADPH oxidase through a Rho-dependent pathway
    Liyan Hou, Xiuqi Bao, Caixia Zang, Hanyu Yang, Fuqiang Sun, Yuning Che, Xuefei Wu, Shao Li, Dan Zhang, Qingshan Wang
    Redox Biology.2018; 14: 600.     CrossRef
  • Serum titers of autoantibodies against α-synuclein and tau in child- and adulthood
    Isabell Kuhn, Tobias Rogosch, Theresa I. Schindler, Björn Tackenberg, Michael Zemlin, Rolf F. Maier, Richard Dodel, Yannick Kronimus
    Journal of Neuroimmunology.2018; 315: 33.     CrossRef
  • Beneficial Effects of Flavonoids Against Parkinson's Disease
    Un Ju Jung, Sang Ryong Kim
    Journal of Medicinal Food.2018; 21(5): 421.     CrossRef
  • Unconventional protein secretion – new insights into the pathogenesis and therapeutic targets of human diseases
    Jiyoon Kim, Heon Yung Gee, Min Goo Lee
    Journal of Cell Science.2018;[Epub]     CrossRef
  • Region-Specific Effects of Immunotherapy With Antibodies Targeting α-synuclein in a Transgenic Model of Synucleinopathy
    Martin Kallab, Marcos Herrera-Vaquero, Malin Johannesson, Fredrik Eriksson, Jessica Sigvardson, Werner Poewe, Gregor K. Wenning, Eva Nordström, Nadia Stefanova
    Frontiers in Neuroscience.2018;[Epub]     CrossRef
  • Gene therapy for neurological disorders: progress and prospects
    Benjamin E. Deverman, Bernard M. Ravina, Krystof S. Bankiewicz, Steven M. Paul, Dinah W. Y. Sah
    Nature Reviews Drug Discovery.2018; 17(9): 641.     CrossRef
  • Combined Active Humoral and Cellular Immunization Approaches for the Treatment of Synucleinopathies
    Edward Rockenstein, Gary Ostroff, Fusun Dikengil, Florentina Rus, Michael Mante, Jazmin Florio, Anthony Adame, Ivy Trinh, Changyoun Kim, Cassia Overk, Eliezer Masliah, Robert A. Rissman
    The Journal of Neuroscience.2018; 38(4): 1000.     CrossRef
  • Holocranohistochemistry enables the visualization of α-synuclein expression in the murine olfactory system and discovery of its systemic anti-microbial effects
    Julianna J. Tomlinson, Bojan Shutinoski, Li Dong, Fanyi Meng, Dina Elleithy, Nathalie A. Lengacher, Angela P. Nguyen, Greg O. Cron, Qiubo Jiang, Erik D. Roberson, Robert L. Nussbaum, Nour K. Majbour, Omar M. El-Agnaf, Steffany A. Bennett, Diane C. Lagace,
    Journal of Neural Transmission.2017; 124(6): 721.     CrossRef
  • Structure, Distribution, and Genetic Profile of α-Synuclein and Their Potential Clinical Application in Parkinson’s Disease
    Xiaoli Si, Jiali Pu, Baorong Zhang
    Journal of Movement Disorders.2017; 10(2): 69.     CrossRef
  • Membrane Trafficking Illuminates a Path to Parkinson’s Disease
    Takafumi Hasegawa, Naoto Sugeno, Akio Kikuchi, Toru Baba, Masashi Aoki
    The Tohoku Journal of Experimental Medicine.2017; 242(1): 63.     CrossRef
  • Decelerated neurodegeneration after intravitreal injection of α-synuclein antibodies in a glaucoma animal model
    J. Teister, F. Anders, S. Beck, S. Funke, H. von Pein, V. Prokosch, N. Pfeiffer, F. Grus
    Scientific Reports.2017;[Epub]     CrossRef
  • Impact of aging immune system on neurodegeneration and potential immunotherapies
    Zhanfeng Liang, Yang Zhao, Linhui Ruan, Linnan Zhu, Kunlin Jin, Qichuan Zhuge, Dong-Ming Su, Yong Zhao
    Progress in Neurobiology.2017; 157: 2.     CrossRef
  • A novel panel of α-synuclein antibodies reveal distinctive staining profiles in synucleinopathies
    Jess-Karan S. Dhillon, Cara Riffe, Brenda D. Moore, Yong Ran, Paramita Chakrabarty, Todd E. Golde, Benoit I. Giasson, Stephan N. Witt
    PLOS ONE.2017; 12(9): e0184731.     CrossRef
  • Vaccination strategies in tauopathies and synucleinopathies
    Anne K. Braczynski, Jörg B. Schulz, Jan‐Philipp Bach
    Journal of Neurochemistry.2017; 143(5): 467.     CrossRef
  • Missions of <italic>Journal of Movement Disorders</italic>
    Yun Joong Kim
    Journal of Movement Disorders.2016; 9(1): 1.     CrossRef
  • How strong is the evidence that Parkinson's disease is a prion disorder?
    Patrik Brundin, Jiyan Ma, Jeffrey H. Kordower
    Current Opinion in Neurology.2016; 29(4): 459.     CrossRef
Original Articles
Article image
Clinical Heterogeneity of Atypical Pantothenate Kinase-Associated Neurodegeneration in Koreans
Jae-Hyeok Lee, Jongkyu Park, Ho-Sung Ryu, Hyeyoung Park, Young Eun Kim, Jin Yong Hong, Sang Ook Nam, Young-Hee Sung, Seung-Hwan Lee, Jee-Young Lee, Myung Jun Lee, Tae-Hyoung Kim, Chul Hyoung Lyoo, Sun Ju Chung, Seong Beom Koh, Phil Hyu Lee, Jin Whan Cho, Mee Young Park, Yun Joong Kim, Young H. Sohn, Beom Seok Jeon, Myung Sik Lee
J Mov Disord. 2016;9(1):20-27.   Published online January 25, 2016
DOI: https://doi.org/10.14802/jmd.15058
  • 21,855 View
  • 235 Download
  • 20 Web of Science
  • 16 Crossref
AbstractAbstract PDFSupplementary Material
Objective
Neurodegeneration with brain iron accumulation (NBIA) represents a group of inherited movement disorders characterized by iron accumulation in the basal ganglia. Recent advances have included the identification of new causative genes and highlighted the wide phenotypic variation between and within the specific NBIA subtypes. This study aimed to investigate the current status of NBIA in Korea.
Methods
We collected genetically confirmed NBIA patients from twelve nationwide referral hospitals and from a review of the literature. We conducted a study to describe the phenotypic and genotypic characteristics of Korean adults with atypical pantothenate kinase-associated neurodegeneration (PKAN).
Results
Four subtypes of NBIA including PKAN (n = 30), PLA2G6-related neurodegeneration (n = 2), beta-propeller protein-associated neurodegeneration (n = 1), and aceruloplasminemia (n = 1) have been identified in the Korean population. The clinical features of fifteen adults with atypical PKAN included early focal limb dystonia, parkinsonism-predominant feature, oromandibular dystonia, and isolated freezing of gait (FOG). Patients with a higher age of onset tended to present with parkinsonism and FOG. The p.R440P and p.D378G mutations are two major mutations that represent approximately 50% of the mutated alleles. Although there were no specific genotype-phenotype correlations, most patients carrying the p.D378G mutation had a late-onset, atypical form of PKAN.
Conclusions
We found considerable phenotypic heterogeneity in Korean adults with atypical PKAN. The age of onset may influence the presentation of extrapyramidal symptoms.

Citations

Citations to this article as recorded by  
  • Typical pantothenate kinase-associated neurodegeneration caused by compound heterozygous mutations in PANK2 gene in a Chinese patient: a case report and literature review
    Yilun Tao, Chen Zhao, Dong Han, Yiju Wei, Lihong Wang, Wenxia Song, Xiaoze Li
    Frontiers in Neurology.2023;[Epub]     CrossRef
  • The first Vietnamese patient who presented late onset of pantothenate kinase-associated neurodegeneration diagnosed by whole exome sequencing: A case report
    Van Khanh Tran, Chi Dung Vu, Hai Anh Tran, Nguyen Thi Kim Lien, Nguyen Van Tung, Nguyen Ngoc Lan, Huy Thinh Tran, Nguyen Huy Hoang
    Medicine.2023; 102(43): e34853.     CrossRef
  • Genetic mutation spectrum of pantothenate kinase-associated neurodegeneration expanded by breakpoint sequencing in pantothenate kinase 2 gene
    Dahae Yang, Sanghyun Cho, Sung Im Cho, Manjin Kim, Moon-Woo Seong, Sung Sup Park
    Orphanet Journal of Rare Diseases.2022;[Epub]     CrossRef
  • Long-Term Outcomes of Deep Brain Stimulation in Pantothenate Kinase-Associated Neurodegeneration-Related Dystonia
    Kyung Ah Woo, Han-Joon Kim, Seung-Ho Jeon, Hye Ran Park, Kye Won Park, Seung Hyun Lee, Sun Ju Chung, Jong-Hee Chae, Sun Ha Paek, Beomseok Jeon
    Journal of Movement Disorders.2022; 15(3): 241.     CrossRef
  • Psychiatric symptoms in an adolescent reveal a novel compound heterozygous mutation of the PANK2 gene in the atypical PKAN syndrome
    Luz María González Huerta, Sorina Gómez González, Jaime Toral López
    Psychiatric Genetics.2021; 31(3): 95.     CrossRef
  • Rational Design of Novel Therapies for Pantothenate Kinase–Associated Neurodegeneration
    Nivedita Thakur, Thomas Klopstock, Suzanne Jackowski, Enej Kuscer, Fernando Tricta, Aleksandar Videnovic, Hyder A. Jinnah
    Movement Disorders.2021; 36(9): 2005.     CrossRef
  • Atypical Pantothenate Kinase-Associated Neurodegeneration with variable phenotypes in an Egyptian family
    Ali S. Shalash, Thomas W. Rösler, Ibrahim Y. Abdelrahman, Hatem S. Abulmakarem, Stefanie H. Müller, Franziska Hopfner, Gregor Kuhlenbäumer, Günter U. Höglinger, Mohamed Salama
    Heliyon.2021; : e07469.     CrossRef
  • Treatment Responsiveness of Parkinsonism in Atypical Pantothenate Kinase‐Associated Neurodegeneration
    Jeanne Feuerstein, Caroline Olvera, Michelle Fullard
    Movement Disorders Clinical Practice.2020;[Epub]     CrossRef
  • Diagnostic and clinical experience of patients with pantothenate kinase-associated neurodegeneration
    Randall D. Marshall, Abigail Collins, Maria L. Escolar, H. A. Jinnah, Thomas Klopstock, Michael C. Kruer, Aleksandar Videnovic, Amy Robichaux-Viehoever, Colleen Burns, Laura L. Swett, Dennis A. Revicki, Randall H. Bender, William R. Lenderking
    Orphanet Journal of Rare Diseases.2019;[Epub]     CrossRef
  • Intrafamilial variability and clinical heterogeneity in a family with PLA2G6-associated neurodegeneration
    Jong Kyu Park, Jinyoung Youn, Jin Whan Cho
    Precision and Future Medicine.2019; 3(3): 135.     CrossRef
  • On the complexity of clinical and molecular bases of neurodegeneration with brain iron accumulation
    C. Tello, A. Darling, V. Lupo, B. Pérez‐Dueñas, C. Espinós
    Clinical Genetics.2018; 93(4): 731.     CrossRef
  • Looking Deep into the Eye-of-the-Tiger in Pantothenate Kinase–Associated Neurodegeneration
    J.-H. Lee, A. Gregory, P. Hogarth, C. Rogers, S.J. Hayflick
    American Journal of Neuroradiology.2018; 39(3): 583.     CrossRef
  • Parkinson’s Disease and Metal Storage Disorders: A Systematic Review
    Edward Botsford, Jayan George, Ellen Buckley
    Brain Sciences.2018; 8(11): 194.     CrossRef
  • Atypical pantothenate kinase-associated neurodegeneration: Clinical description of two brothers and a review of the literature
    S. Mahoui, A. Benhaddadi, W. Ameur El Khedoud, M. Abada Bendib, M. Chaouch
    Revue Neurologique.2017; 173(10): 658.     CrossRef
  • Clinical rating scale for pantothenate kinase‐associated neurodegeneration: A pilot study
    Alejandra Darling, Cristina Tello, María Josep Martí, Cristina Garrido, Sergio Aguilera‐Albesa, Miguel Tomás Vila, Itziar Gastón, Marcos Madruga, Luis González Gutiérrez, Julio Ramos Lizana, Montserrat Pujol, Tania Gavilán Iglesias, Kylee Tustin, Jean Pie
    Movement Disorders.2017; 32(11): 1620.     CrossRef
  • Missions of <italic>Journal of Movement Disorders</italic>
    Yun Joong Kim
    Journal of Movement Disorders.2016; 9(1): 1.     CrossRef
Article image
Movement Disorders in Non-Wilsonian Cirrhotic Patients: A Report of the Prevalence and Risk Factors from a Study Done in a Medical School in an Agricultural-Based Community
Kulthida Methawasin, Piyanant Chonmaitree, Chatchawan Wongjitrat, Suthee Rattanamongkolgul, Thanin Asawavichienjinda
J Mov Disord. 2016;9(1):28-34.   Published online December 3, 2015
DOI: https://doi.org/10.14802/jmd.15034
  • 20,219 View
  • 85 Download
  • 2 Crossref
AbstractAbstract PDF
Objective
Parkinsonism and other movement disorders have previously been reported in the acquired hepatocerebral degeneration associated with portosystemic shunting. However, there is no study to date about their prevalence as has been noted in general practice.
Methods
One hundred and forty-three patients with hepatic cirrhosis from the gastroenterology clinic and internal medicine wards were enrolled. Liver data included the diagnoses, etiologies, assessments of complications, and treatments for cirrhosis. Hepatic encephalopathy was classified with regard to the West Haven criteria for semi-quantitative grading for mental status. Neurological examination results and abnormal involuntary movements were recorded as primary outcomes. Neuro-radiology was used for the detection of severe brain lesions.
Results
Alcoholism was the most common cause of liver cirrhosis. Eighty-three patients (58%) presented with movement disorders. Asterixis was found in one of the cases. The most common movement disorder seen was an intentional tremor at 37.1%, which was followed by bradykinesia, Parkinsonism, and postural tremors at 29.4%, 10.5%, and 6.3%, respectively. The prevalence of movement disorders simultaneously increased with a high Child-Turcotte-Pugh score. The hepatic encephalopathy was grade 1 and 2. With the inclusion of age-range adjustments, we found that alcoholic cirrhosis and hepatic encephalopathy are statistically significant factors [p < 0.05, odds ratio (OR) = 6.41, 95% confidence interval (CI) 1.38–29.71 and p < 0.001, OR = 13.65, 95% CI 4.71–39.54] for the development of movement disorders in non-Wilsonian cirrhotic patients. Conclusions Intentional tremor is a common abnormal movement. Alcoholic cirrhosis and hepatic encephalopathy are significant risk factors in the development of movement disorders in non-Wilsonian cirrhotic patients.

Citations

Citations to this article as recorded by  
  • Investigating the Relationship between Chronic Liver Cirrhosis and Parkinsonism: A Comparative Analysis and a Suggested Diagnostic Scheme
    Tal Sigawi, Omer Hamtzany, Noa Hurvitz, Yuval Ishay, Roy Dayan, David Arkadir, Yaron Ilan
    Clinics and Practice.2024; 14(4): 1375.     CrossRef
  • A Prospective Study of the Prevalence of Parkinsonism in Patients With Liver Cirrhosis
    Diana Apetauerova, Peter Hildebrand, Stephanie Scala, Janet W. Zani, LeeAnne Lipert, Erin Clark, Tanya Fennell, Fredric D. Gordon
    Hepatology Communications.2021; 5(2): 323.     CrossRef
Article image
N30 Somatosensory Evoked Potential Is Negatively Correlated with Motor Function in Parkinson’s Disease
Suk Yun Kang, Hyeo-Il Ma
J Mov Disord. 2016;9(1):35-39.   Published online January 25, 2016
DOI: https://doi.org/10.14802/jmd.15038
  • 25,710 View
  • 88 Download
  • 6 Web of Science
  • 3 Crossref
AbstractAbstract PDF
Objective
aaThe aim of this study was to investigate frontal N30 status in Parkinson’s disease (PD) and to examine the correlation between the amplitude of frontal N30 and the severity of motor deficits.
Methods
aaThe frontal N30 was compared between 17 PD patients and 18 healthy volunteers. Correlations between the amplitude of frontal N30 and the Unified Parkinson’s Disease Rating Scale (UPDRS) motor score of the more severely affected side was examined.
Results
aaThe mean latency of the N30 was not significantly different between patients and healthy volunteers (p = 0.981), but the mean amplitude was lower in PD patients (p < 0.025). There was a significant negative correlation between the amplitude of N30 and the UPDRS motor score (r = -0.715, p = 0.013).
Conclusions
The frontal N30 status indicates the motor severity of PD. It can be a useful biomarker reflecting dopaminergic deficits and an objective measurement for monitoring the clinical severity of PD.

Citations

Citations to this article as recorded by  
  • A Comparison of Sensorimotor Integration and Motor Fitness Components between Collegiate Athletes with and without Long COVID: A Cross-Sectional Study with Pair-Matched Controls
    Ibrahim M. Moustafa, Amal Ahbouch, Raheesa P. Kader, Tamer Mohamed Shousha, Abdulla Alrahoomi
    Journal of Clinical Medicine.2024; 13(9): 2469.     CrossRef
  • Clinical factors affecting evoked magnetic fields in patients with Parkinson's disease
    Ryoji Naganuma, Ichiro Yabe, Megumi Takeuchi, Kirari Morishita, Shingo Nakane, Ryoken Takase, Ikuko Takahashi-Iwata, Masaaki Matsushima, Mika Otsuki, Hideaki Shiraishi, Hidenao Sasaki, Wing-ho Yung
    PLOS ONE.2020; 15(9): e0232808.     CrossRef
  • Short-Term Effects of Thoracic Spine Manipulation on the Biomechanical Organisation of Gait Initiation: A Randomized Pilot Study
    Sébastien Ditcharles, Eric Yiou, Arnaud Delafontaine, Alain Hamaoui
    Frontiers in Human Neuroscience.2017;[Epub]     CrossRef
Can Postural Instability Respond to Galvanic Vestibular Stimulation in Patients with Parkinson’s Disease?
Hiroshi Kataoka, Yohei Okada, Takao Kiriyama, Yorihiro Kita, Junji Nakamura, Shu Morioka, Koji Shomoto, Satoshi Ueno
J Mov Disord. 2016;9(1):40-43.   Published online December 3, 2015
DOI: https://doi.org/10.14802/jmd.15030
  • 23,311 View
  • 199 Download
  • 36 Crossref
AbstractAbstract PDFSupplementary Material
Objective
Galvanic vestibular stimulation (GVS) activates the vestibular afferents, and these changes in vestibular input exert a strong influence on the subject’s posture or standing balance. In patients with Parkinson’s disease (PD), vestibular dysfunction might contribute to postural instability and gait disorders.
Methods
Current intensity was increased to 0.7 mA, and the current was applied to the patients for 20 minutes. To perform a sham stimulation, the current intensity was increased as described and then decreased to 0 mA over the course of 10 seconds. The patient’s status was recorded continuously for 20 minutes with the patient in the supine position.
Results
Three out of 5 patients diagnosed with PD with postural instability and/or abnormal axial posture showed a reduction in postural instability after GVS. The score for item 12 of the revised Unified Parkinson’s Disease Rating Scale part 3 was decreased in these patients.
Conclusions
The mechanism of postural instability is complex and not completely understood. In 2 out of the 5 patients, postural instability was not changed in response to GVS. Nonetheless, the GVS-induced change in postural instability for 3 patients in our study suggests that GVS might be a therapeutic option for postural instability.

Citations

Citations to this article as recorded by  
  • Vestibular dysfunction in Parkinson’s disease: a neglected topic
    Meilin Gui, Lingling Lv, Lixia Qin, Chunyu Wang
    Frontiers in Neurology.2024;[Epub]     CrossRef
  • Vestibular Neurostimulation for Parkinson’s Disease: A Novel Device-Aided Non-Invasive Therapeutic Option
    K. Ray Chaudhuri, Karolina Poplawska-Domaszewicz, Naomi Limbachiya, Mubasher Qamar, Lucia Batzu, Aleksandra Podlewska, Kristen Ade
    Journal of Personalized Medicine.2024; 14(9): 933.     CrossRef
  • Beyond balance: The role of the Vestibular system in action recognition
    Roberto Gammeri, Maria-Chiara Villa, Tommaso Ciorli, Anna Berti, Raffaella Ricci
    Heliyon.2024; 10(18): e38019.     CrossRef
  • Impact of galvanic vestibular stimulation electrode current density on brain current flow patterns: Does electrode size matter?
    Dennis Q. Truong, Alexander Guillen, Mujda Nooristani, Maxime Maheu, Francois Champoux, Abhishek Datta, Mohammad Ali Salehinejad
    PLOS ONE.2023; 18(2): e0273883.     CrossRef
  • The Effectiveness of Electrical Vestibular Stimulation (VeNS) on Symptoms of Anxiety: Study Protocol of a Randomized, Double-Blinded, Sham-Controlled Trial
    Teris Cheung, Joyce Yuen Ting Lam, Kwan Hin Fong, Yuen Shan Ho, Alex Ho, Calvin Pak-Wing Cheng, Julie Sittlington, Yu-Tao Xiang, Tim Man Ho Li
    International Journal of Environmental Research and Public Health.2023; 20(5): 4218.     CrossRef
  • Acceptability and feasibility of a vestibular nerve stimulation headset protocol in children with cerebral palsy
    Karen McConnell, Daniel Topley, Jason McKeown, Claire Kerr
    BMC Pediatrics.2022;[Epub]     CrossRef
  • Effect of galvanic vestibular stimulation on axial symptoms in Parkinson’s disease
    Hiroshi Kataoka, Yohei Okada, Takao Kiriyama, Yorihiro Kita, Junji Nakamura, Koji Shomoto, Kazuma Sugie
    Journal of Central Nervous System Disease.2022; 14: 117957352210815.     CrossRef
  • Galvanic vestibular stimulation and its applications: a systematic review
    Anna Paula Batista de Ávila Pires, Tatiana Rocha Silva, Maíra Soares Torres, Maria Luiza Diniz, Maurício Campelo Tavares, Denise Utsch Gonçalves
    Brazilian Journal of Otorhinolaryngology.2022; 88: S202.     CrossRef
  • Detection and assessment of Parkinson's disease based on gait analysis: A survey
    Yao Guo, Jianxin Yang, Yuxuan Liu, Xun Chen, Guang-Zhong Yang
    Frontiers in Aging Neuroscience.2022;[Epub]     CrossRef
  • EFFECT OF VESTIBULAR STIMULATION ON BEHAVIORAL CHANGES IN PARKINSON DISEASE-INDUCED MICE
    Ram Mohan, Mohan Jayabal, Rashmi Ramanathan, Jeevithan Shanmugam, Archana R
    Asian Journal of Pharmaceutical and Clinical Research.2022; : 84.     CrossRef
  • IMPACT OF CALORIC VESTIBULAR STIMULATION ON CO-ORDINATION IN PARKINSON DISEASE INDUCED MICE
    RAM MOHAN, KAYALVIZHI, RASHMI RAMANATHAN, JEEVITHAN SHANMUGAM, ARCHANA R.
    International Journal of Pharmacy and Pharmaceutical Sciences.2022; : 46.     CrossRef
  • The effect of galvanic vestibular stimulation on postural balance in Parkinson's disease: A systematic review and meta-analysis
    Mohammad Mahmud, Zaeem Hadi, Mabel Prendergast, Matteo Ciocca, Abdel Rahman Saad, Yuscah Pondeca, Yen Tai, Gregory Scott, Barry M. Seemungal
    Journal of the Neurological Sciences.2022; 442: 120414.     CrossRef
  • A systematic review of vestibular stimulation in cerebral palsy
    Daniel Topley, Karen McConnell, Claire Kerr
    Disability and Rehabilitation.2021; 43(23): 3291.     CrossRef
  • The link between lateral trunk flexion in Parkinson’s disease and vestibular dysfunction: a clinical study
    Haiyan Tang, You Chen, Zhidong Cen, Zhiyuan Ouyang, Danning Lou, Ying Tan, Wei Luo
    International Journal of Neuroscience.2021; 131(6): 521.     CrossRef
  • Vestibular stimulation: a noninvasive brain stimulation in Parkinson’s disease & its implications
    Thanalakshmi Jagadeesan, Archana Rajagopal, Senthilkumar Sivanesan
    Journal of Complementary and Integrative Medicine.2021; 18(4): 657.     CrossRef
  • Current perspectives on galvanic vestibular stimulation in the treatment of Parkinson’s disease
    Soojin Lee, Aiping Liu, Martin J. McKeown
    Expert Review of Neurotherapeutics.2021; 21(4): 405.     CrossRef
  • Caloric and galvanic vestibular stimulation for the treatment of Parkinson’s disease: rationale and prospects
    David Wilkinson
    Expert Review of Medical Devices.2021; 18(7): 649.     CrossRef
  • Early balance impairment in Parkinson’s Disease: Evidence from Robot-assisted axial rotations
    Alessandro Zampogna, Ilaria Mileti, Francesca Martelli, Marco Paoloni, Zaccaria Del Prete, Eduardo Palermo, Antonio Suppa
    Clinical Neurophysiology.2021; 132(10): 2422.     CrossRef
  • Dizziness in Parkinson’s disease patients is associated with vestibular function
    Jeong-Ho Park, Suk Yun Kang
    Scientific Reports.2021;[Epub]     CrossRef
  • c-Fos Expression after Stochastic Vestibular Stimulation and Levodopa in 6-OHDA Hemilesioned Rats
    Ghazaleh Samoudi, Andrea Nilsson, Thomas Carlsson, Filip Bergquist
    Neuroscience.2020; 424: 146.     CrossRef
  • Sensory Neuromodulation
    Robert D. Black, Lesco L. Rogers
    Frontiers in Systems Neuroscience.2020;[Epub]     CrossRef
  • Efficacy of transmastoidal galvanic stimulation on recovery outcomes in patients with unilateral peripheral vestibular disorders: a randomized controlled trial
    Reham Ali Mohamed Ali Ahmed, Ebtesam Mohamed Fahmy, Amina Mohamed Awad, Mona Mohamed Hamdy, Hussein Ahmed Abd Rahman Shaker
    The Egyptian Journal of Neurology, Psychiatry and Neurosurgery.2020;[Epub]     CrossRef
  • Effect of caloric vestibular stimulation on brain neurochemicals in rotenone induced mouse model of Parkinson’s disease
    Sai Sailesh Kumar G, Srilatha Bashetti
    International Journal of Clinical Biochemistry and Research.2020; 7(1): 49.     CrossRef
  • The Effect of L-dopa on Postural Stability in Parkinson’s Disease Patients
    Jacek Wilczyński, Natalia Habik
    Applied Sciences.2019; 9(3): 409.     CrossRef
  • Receptor Ligands as Helping Hands to L-DOPA in the Treatment of Parkinson’s Disease
    Fabio Bello, Mario Giannella, Gianfabio Giorgioni, Alessandro Piergentili, Wilma Quaglia
    Biomolecules.2019; 9(4): 142.     CrossRef
  • Aplicações dos potenciais evocados miogênicos vestibulares: revisão sistemática de literatura
    Tatiana Rocha Silva, Marco Aurélio Rocha Santos, Luciana Macedo de Resende, Ludimila Labanca, Júlia Fonseca de Morais Caporali, Marjore Rhaissa de Sousa, Denise Utsch Gonçalves
    Audiology - Communication Research.2019;[Epub]     CrossRef
  • Caloric vestibular stimulation for the management of motor and non-motor symptoms in Parkinson's disease
    David Wilkinson, Aleksandra Podlewska, Sarah E. Banducci, Tracy Pellat-Higgins, Martin Slade, Mayur Bodani, Mohamed Sakel, Lanty Smith, Peter LeWitt, Kristen K. Ade
    Parkinsonism & Related Disorders.2019; 65: 261.     CrossRef
  • Deterioration of postural deformity in Parkinson’s disease patients with punding and hobbyism
    Ryoma Aoki, Makoto Shiraishi, Kyohei Mikami, Tsutomu Kamo
    Journal of Clinical Neuroscience.2019; 69: 179.     CrossRef
  • Recent advancements in lateral trunk flexion in Parkinson disease
    Hiroshi Kataoka, Kazuma Sugie
    Neurology Clinical Practice.2019; 9(1): 74.     CrossRef
  • Galvanic Vestibular Stimulation (GVS) Augments Deficient Pedunculopontine Nucleus (PPN) Connectivity in Mild Parkinson's Disease: fMRI Effects of Different Stimuli
    Jiayue Cai, Soojin Lee, Fang Ba, Saurabh Garg, Laura J. Kim, Aiping Liu, Diana Kim, Z. Jane Wang, Martin J. McKeown
    Frontiers in Neuroscience.2018;[Epub]     CrossRef
  • Effects of Galvanic Vestibular Stimulation on Upper and Lower Extremities Motor Symptoms in Parkinson’s Disease
    Mahta Khoshnam, Daniela M. C. Häner, Eunice Kuatsjah, Xin Zhang, Carlo Menon
    Frontiers in Neuroscience.2018;[Epub]     CrossRef
  • Vestibular Functions and Parkinson's Disease
    Paul F. Smith
    Frontiers in Neurology.2018;[Epub]     CrossRef
  • Body Posture, Postural Stability, and Metabolic Age in Patients with Parkinson’s Disease
    Jacek Wilczyński, Agnieszka Pedrycz, Dariusz Mucha, Tadeusz Ambroży, Dawid Mucha
    BioMed Research International.2017; 2017: 1.     CrossRef
  • Vestibular Deficits in Neurodegenerative Disorders: Balance, Dizziness, and Spatial Disorientation
    Thomas Cronin, Qadeer Arshad, Barry M. Seemungal
    Frontiers in Neurology.2017;[Epub]     CrossRef
  • Vestibular neuromodulation: stimulating the neural crossroads of psychiatric illness
    Steven M Miller
    Bipolar Disorders.2016; 18(6): 539.     CrossRef
  • Non-Invasive Neuromodulation Using Time-Varying Caloric Vestibular Stimulation
    Robert D. Black, Lesco L. Rogers, Kristen K. Ade, Heather A. Nicoletto, Heather D. Adkins, Daniel T. Laskowitz
    IEEE Journal of Translational Engineering in Health and Medicine.2016; 4: 1.     CrossRef
Article image
Reduced Neck Muscle Strength and Altered Muscle Mechanical Properties in Cervical Dystonia Following Botulinum Neurotoxin Injections: A Prospective Study
Sirpa Mustalampi, Jari Ylinen, Katariina Korniloff, Adam Weir, Arja H?kkinen
J Mov Disord. 2016;9(1):44-49.   Published online January 25, 2016
DOI: https://doi.org/10.14802/jmd.15035
  • 14,816 View
  • 124 Download
  • 3 Web of Science
  • 2 Crossref
AbstractAbstract PDF
Objective
To evaluate changes in the strength and mechanical properties of neck muscles and disability in patients with cervical dystonia (CD) during a 12-week period following botulinum neurotoxin (BoNT) injections.
Methods
Eight patients with CD volunteered for this prospective clinical cohort study. Patients had received BoNT injections regularly in neck muscles at three-month intervals for several years. Maximal isometric neck strength was measured by a dynamometer, and the mechanical properties of the splenius capitis were evaluated using two myotonometers. Clinical assessment was performed using the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) before and at 2, 4, 8, and 12 weeks after the BoNT injections.
Results
Mean maximal isometric neck strength at two weeks after the BoNT injections decreased by 28% in extension, 25% in rotation of the affected side and 17% in flexion. At four weeks, muscle stiffness of the affected side decreased by 17% and tension decreased by 6%. At eight weeks, the muscle elasticity on the affected side increased by 12%. At two weeks after the BoNT injections, the TWSTRS-severity and TWSTRS-total scores decreased by 4.3 and 6.4, respectively. The strength, muscle mechanical properties and TWSTRS scores returned to baseline values at 12 weeks.
Conclusions
Although maximal neck strength and muscle tone decreased after BoNT injections, the disability improved. The changes observed after BoNT injections were temporary and returned to pre-injection levels within twelve weeks. Despite having a possible negative effect on function and decreasing neck strength, the BoNT injections improved the patients reported disability.

Citations

Citations to this article as recorded by  
  • Paravertebral Muscle Mechanical Properties and Spinal Range of Motion in Patients with Acute Neck or Low Back Pain: A Case-Control Study
    Sandra Alcaraz-Clariana, Lourdes García-Luque, Juan Luis Garrido-Castro, César Fernández-de-las-Peñas, Cristina Carmona-Pérez, Daiana Priscila Rodrigues-de-Souza, Francisco Alburquerque-Sendín
    Diagnostics.2021; 11(2): 352.     CrossRef
  • Paravertebral Muscle Mechanical Properties in Patients with Axial Spondyloarthritis or Low Back Pain: A Case-Control Study
    Sandra Alcaraz-Clariana, Lourdes García-Luque, Juan Luis Garrido-Castro, I. Concepción Aranda-Valera, Lourdes Ladehesa-Pineda, María Ángeles Puche-Larrubia, Cristina Carmona-Pérez, Daiana Priscila Rodrigues-de-Souza, Francisco Alburquerque-Sendín
    Diagnostics.2021; 11(10): 1898.     CrossRef
Letters to the editor
Acute Chorea Onset after Hot Food Consumption in a Patient with Moyamoya Disease
Hye Young Jung, Jee Eun Lee, Ilung Kang, Yong Bang Kim, Hyung-Eun Park, Joong-Seok Kim
J Mov Disord. 2016;9(1):50-52.   Published online January 25, 2016
DOI: https://doi.org/10.14802/jmd.15048
  • 17,264 View
  • 78 Download
  • 6 Web of Science
  • 6 Crossref
PDFSupplementary Material

Citations

Citations to this article as recorded by  
  • Transient Hemichorea-hemiballism Induced by a Combination of Postprandial Hypotension and Severe Stenosis of the Innominate Artery Concomitant with Left Carotid Occlusion
    Sho Okune, Mikito Hayakawa, Tenyu Hino, Takato Hiramine, Taisuke Akimoto, Masayuki Sato, Yoshiro Ito, Aiki Marushima, Tomoya Takada, Eiichi Ishikawa, Akira Tamaoka, Yuji Matsumaru
    Internal Medicine.2024; 63(4): 577.     CrossRef
  • Spicy foods triggering clinical symptoms in Moyamoya angiopathy
    Souvik DUBEY, Ritwik GHOSH, Subhankar CHATTERJEE, Mahua J. DUBEY, Biman K. RAY, Shambaditya DAS, Apratim CHATTERJEE, Durjoy LAHIRI, Markus KRAEMER
    Journal of Neurosurgical Sciences.2021;[Epub]     CrossRef
  • Corticostriatal Hypermetabolism in Moyamoya Disease-Induced Hemichorea: Two Case Reports and a Literature Review
    Wen-biao Xian, Xiang-song Zhang, Xin-chong Shi, Gan-hua Luo, Chang Yi, Zhong Pei
    Frontiers in Neurology.2021;[Epub]     CrossRef
  • Transient Ischemic Attack after Eating Spicy Foods in Children: Think of Moya Moya Disease
    Thomas Mathew, DelonD Souza, SajiK John, GG Sharath Kumar
    Neurology India.2021; 69(4): 1032.     CrossRef
  • Asymmetric lenticulostriate arteries in patients with moyamoya disease presenting with movement disorder: three new cases
    Jiali Xu, Sijie Li, Gary B. Rajah, Wenbo Zhao, Changhong Ren, Yuchuan Ding, Qian Zhang, Xunming Ji
    Neurological Research.2020; 42(8): 665.     CrossRef
  • Movement Disorders Following Cerebrovascular Lesions: Etiology, Treatment Options and Prognosis
    Do-Young Kwon
    Journal of Movement Disorders.2016; 9(2): 63.     CrossRef
The Problem of Functional
Jung E Park
J Mov Disord. 2016;9(1):53-54.   Published online December 3, 2015
DOI: https://doi.org/10.14802/jmd.15044
  • 13,485 View
  • 98 Download
PDF

JMD : Journal of Movement Disorders Twitter
Close layer
TOP