Journal of Movement Disorders

Volume 13(3); September 2020

Review Articles

Emerging Concepts of Motor Reserve in Parkinson’s Disease: Seok Jong Chung, Jae Jung Lee, Phil Hyu Lee, Young H. Sohn; J Mov Disord. 2020;13(3):171-184. Published online August 31, 2020; DOI: https://doi.org/10.14802/jmd.20029

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The concept of cognitive reserve (CR) in Alzheimer’s disease (AD) explains the differences between individuals in their susceptibility to AD-related pathologies. An enhanced CR may lead to less cognitive deficits despite severe pathological lesions. Parkinson’s disease (PD) is also a common neurodegenerative disease and is mainly characterized by motor dysfunction related to striatal dopaminergic depletion. The degree of motor deficits in PD is closely correlated to the degree of dopamine depletion; however, significant individual variations still exist. Therefore, we hypothesized that the presence of motor reserve (MR) in PD explains the individual differences in motor deficits despite similar levels of striatal dopamine depletion. Since 2015, we have performed a series of studies investigating MR in de novo patients with PD using the data of initial clinical presentation and dopamine transporter PET scan. In this review, we summarized the results of these published studies. In particular, some premorbid experiences (i.e., physical activity and education) and modifiable factors (i.e., body mass index and white matter hyperintensity on brain image studies) could modulate an individual’s capacity to tolerate PD pathology, which can be maintained throughout disease progression.

Citations

Citations to this article as recorded by

Patterns of striatal dopamine depletion and motor deficits in de novo Parkinson’s disease
Seong Ho Jeong, Chan Wook Park, Hye Sun Lee, Yun Joong Kim, Mijin Yun, Phil Hyu Lee, Young H. Sohn, Seok Jong Chung
Journal of Neural Transmission.2023; 130(1): 19. CrossRef
Premorbid Educational Attainment and Long-Term Motor Prognosis in Parkinson’s Disease
Seong Ho Jeong, Seok Jong Chung, Han Soo Yoo, Jin Ho Jung, Kyoungwon Baik, Yang Hyun Lee, Phil Hyu Lee, Young H. Sohn
Journal of Parkinson's Disease.2022; 12(1): 129. CrossRef
Parkinsonism and cerebrovascular disease
Manisha Narasimhan, Raymond Schwartz, Glenda Halliday
Journal of the Neurological Sciences.2022; 433: 120011. CrossRef
Impact of α‐synuclein spreading on the nigrostriatal dopaminergic pathway depends on the onset of the pathology
Fanfan Sun, Armando G. Salinas, Severin Filser, Sonja Blumenstock, Jose Medina‐Luque, Jochen Herms, Carmelo Sgobio
Brain Pathology.2022;[Epub] CrossRef
Premorbid cancer and motor reserve in patients with Parkinson’s disease
Yoon-Sang Oh, Sang-Won Yoo, Chul Hyoung Lyoo, Kwang-Soo Lee, Joong-Seok Kim
Scientific Reports.2022;[Epub] CrossRef
Behavioral Reserve in Behavioral Variant Frontotemporal Dementia
Su Hong Kim, Yae Ji Kim, Byung Hwa Lee, Peter Lee, Ji Hyung Park, Sang Won Seo, Yong Jeong
Frontiers in Aging Neuroscience.2022;[Epub] CrossRef
Identifying the white matter structural network of motor reserve in early Parkinson's disease
Yae Ji Kim, Chan Wook Park, Hye Won Shin, Hye Sun Lee, Yun Joong Kim, Mijin Yun, Phil Hyu Lee, Young H. Sohn, Yong Jeong, Seok Jong Chung
Parkinsonism & Related Disorders.2022; 102: 108. CrossRef
Motor progression marker for newly diagnosed drug‐naïve patients with Parkinson's disease: A resting‐state functional MRI study
Yanbing Hou, Lingyu Zhang, Ruwei Ou, Qianqian Wei, Xiaojing Gu, Kuncheng Liu, Junyu Lin, Tianmi Yang, Yi Xiao, Qiyong Gong, Huifang Shang
Human Brain Mapping.2022;[Epub] CrossRef
Comparison of disease progression between brain-predominant Parkinson's disease versus Parkinson's disease with body-involvement phenotypes
Dong-Woo Ryu, Sang-Won Yoo, Yoon-Sang Oh, Kwang-Soo Lee, Seunggyun Ha, Joong-Seok Kim
Neurobiology of Disease.2022; 174: 105883. CrossRef
Genetically-informed prediction of short-term Parkinson’s disease progression
Hossein J. Sadaei, Aldo Cordova-Palomera, Jonghun Lee, Jaya Padmanabhan, Shang-Fu Chen, Nathan E. Wineinger, Raquel Dias, Daria Prilutsky, Sandor Szalma, Ali Torkamani
npj Parkinson's Disease.2022;[Epub] CrossRef
Potential Link Between Cognition and Motor Reserve in Patients With Parkinson’s Disease
Seok Jong Chung, Yae Ji Kim, Yun Joong Kim, Hye Sun Lee, Mijin Yun, Phil Hyu Lee, Yong Jeong, Young H. Sohn
Journal of Movement Disorders.2022; 15(3): 249. CrossRef
The Concept of Motor Reserve in Parkinson's Disease: New Wine in Old Bottles?
Merle C. Hoenig, Verena Dzialas, Alexander Drzezga, Thilo van Eimeren
Movement Disorders.2022;[Epub] CrossRef
Local striatal volume and motor reserve in drug-naïve Parkinson’s disease
Seong Ho Jeong, Eun-Chong Lee, Seok Jong Chung, Hye Sun Lee, Jin Ho Jung, Young H. Sohn, Joon-Kyung Seong, Phil Hyu Lee
npj Parkinson's Disease.2022;[Epub] CrossRef
Effectiveness and safety of electroacupuncture in treating Parkinson disease
Wei Xu, Sha OuYang, Zhenhai Chi, ZhiQin Wang, DaoCheng Zhu, RiXin Chen, GenPing Zhong, FengTing Zhang, GuiQin Zhou, SiWei Duan, Lin Jiao
Medicine.2021; 100(10): e25095. CrossRef
Differences in cause and 12-month follow-up outcome of parkinsonian symptoms in depressed older adults treated with antipsychotics: a case series
Anastasios Politis, Nikolaos Kokras, Michael Souvatzoglou, Kostas Siarkos, Panagiotis Toulas, Constantin Potagas, Theodoros Hatzipanagiotou, Georgios Limouris, Panagiotis Alexopoulos
BMC Psychiatry.2021;[Epub] CrossRef
Effectiveness and safety of moxibustion for Parkinson disease
Yonghui Hou, Baile Ning, Yamin Liu, Ying Liu, Wenbin Fu, Zehuai Wen
Medicine.2021; 100(23): e26256. CrossRef
Glucocerebrosidase Mutations and Motor Reserve in Parkinson’s Disease
Seok Jong Chung, Phil Hyu Lee, Young H. Sohn, Yun Joong Kim
Journal of Parkinson's Disease.2021; 11(4): 1715. CrossRef
Analysis of pupillometer results according to disease stage in patients with Parkinson’s disease
Sooyeoun You, Jeong-Ho Hong, Joonsang Yoo
Scientific Reports.2021;[Epub] CrossRef

Update on Current Technologies for Deep Brain Stimulation in Parkinson’s Disease: Michelle Paff, Aaron Loh, Can Sarica, Andres M. Lozano, Alfonso Fasano; J Mov Disord. 2020;13(3):185-198. Published online August 31, 2020; DOI: https://doi.org/10.14802/jmd.20052

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35 Citations

Abstract PDF

Deep brain stimulation (DBS) is becoming increasingly central in the treatment of patients with Parkinson’s disease and other movement disorders. Recent developments in DBS lead and implantable pulse generator design provide increased flexibility for programming, potentially improving the therapeutic benefit of stimulation. Directional DBS leads may increase the therapeutic window of stimulation by providing a means of avoiding current spread to structures that might give rise to stimulation-related side effects. Similarly, control of current to individual contacts on a DBS lead allows for shaping of the electric field produced between multiple active contacts. The following review aims to describe the recent developments in DBS system technology and the features of each commercially available DBS system. The advantages of each system are reviewed, and general considerations for choosing the most appropriate system are discussed.

Citations

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Long-term motor outcomes of deep brain stimulation of the globus pallidus interna in Parkinson's disease patients: Five-year follow-up
Yun Su Hwang, Sungyang Jo, Seung Hyun Lee, Nayoung Kim, Mi-Sun Kim, Sang Ryong Jeon, Sun Ju Chung
Journal of the Neurological Sciences.2023; 444: 120484. CrossRef
Brain stimulation treatments in epilepsy: Basic mechanisms and clinical advances
Thomas J. Foutz, Michael Wong
Biomedical Journal.2022; 45(1): 27. CrossRef
Neurodegenerative disorders management: state-of-art and prospects of nano-biotechnology
Raj Kumar, Keshaw Ram Aadil, Kunal Mondal, Yogendra Kumar Mishra, David Oupicky, Seeram Ramakrishna, Ajeet Kaushik
Critical Reviews in Biotechnology.2022; 42(8): 1180. CrossRef
Sleep and circadian rhythms in Parkinson’s disease and preclinical models
Jeremy Hunt, Elizabeth J. Coulson, Rajendram Rajnarayanan, Henrik Oster, Aleksandar Videnovic, Oliver Rawashdeh
Molecular Neurodegeneration.2022;[Epub] CrossRef
Jose Delgado: A controversial trailblazer in neuromodulation
Nicholas D. Lorusso, Uma R. Mohan, Joshua Jacobs
Artificial Organs.2022; 46(4): 531. CrossRef
Local and distant cortical responses to single pulse intracranial stimulation in the human brain are differentially modulated by specific stimulation parameters
Angelique C. Paulk, Rina Zelmann, Britni Crocker, Alik S. Widge, Darin D. Dougherty, Emad N. Eskandar, Daniel S. Weisholtz, R. Mark Richardson, G. Rees Cosgrove, Ziv M. Williams, Sydney S. Cash
Brain Stimulation.2022;[Epub] CrossRef
Proceedings of the Ninth Annual Deep Brain Stimulation Think Tank: Advances in Cutting Edge Technologies, Artificial Intelligence, Neuromodulation, Neuroethics, Pain, Interventional Psychiatry, Epilepsy, and Traumatic Brain Injury
Joshua K. Wong, Günther Deuschl, Robin Wolke, Hagai Bergman, Muthuraman Muthuraman, Sergiu Groppa, Sameer A. Sheth, Helen M. Bronte-Stewart, Kevin B. Wilkins, Matthew N. Petrucci, Emilia Lambert, Yasmine Kehnemouyi, Philip A. Starr, Simon Little, Juan Ans
Frontiers in Human Neuroscience.2022;[Epub] CrossRef
Past, Present, and Future of Deep Brain Stimulation: Hardware, Software, Imaging, Physiology and Novel Approaches
Jessica Frey, Jackson Cagle, Kara A. Johnson, Joshua K. Wong, Justin D. Hilliard, Christopher R. Butson, Michael S. Okun, Coralie de Hemptinne
Frontiers in Neurology.2022;[Epub] CrossRef
Parkinson’s Disease Management via Wearable Sensors: A Systematic Review
Huma Mughal, Abdul Rehman Javed, Muhammad Rizwan, Ahmad S. Almadhor, Natalia Kryvinska
IEEE Access.2022; 10: 35219. CrossRef
Conversion to Hybrid Deep Brain Stimulation System to Enable Multi‐Contact Fractionation Can be Therapeutic
Disep I. Ojukwu, Allan R. Wang, Traci S. Hornbeck, Erika A. Lim, Jennifer Sharrard, Rohit Dhall, Vivek P. Buch, Casey H. Halpern
Movement Disorders.2022; 37(6): 1321. CrossRef
Developments in Deep Brain Stimulators for Successful Aging Towards Smart Devices—An Overview
Angelito A. Silverio, Lean Angelo A. Silverio
Frontiers in Aging.2022;[Epub] CrossRef
Single-interface bioelectronic medicines—concept, clinical applications and preclinical data
Cristian Sevcencu
Journal of Neural Engineering.2022; 19(3): 031001. CrossRef
Current Steering Using Multiple Independent Current Control Deep Brain Stimulation Technology Results in Distinct Neurophysiological Responses in Parkinson’s Disease Patients
Jana Peeters, Alexandra Boogers, Tine Van Bogaert, Robin Gransier, Jan Wouters, Bart Nuttin, Myles Mc Laughlin
Frontiers in Human Neuroscience.2022;[Epub] CrossRef
Managing Intractable Symptoms of Parkinson's Disease: A Nonsurgical Approach Employing Infralow Frequency Neuromodulation
Stella B. Legarda, P. Andreas Michas-Martin, Dana McDermott
Frontiers in Human Neuroscience.2022;[Epub] CrossRef
Directional Deep Brain Stimulation in the Treatment of Parkinson's Disease
Akash Mishra, Ritesh A Ramdhani
Neurology.2022; 18(1): 64. CrossRef
Approach to the Treatment of Pediatric Dystonia
Carolina Gorodetsky, Alfonso Fasano
Dystonia.2022;[Epub] CrossRef
CRISPR and iPSCs: Recent Developments and Future Perspectives in Neurodegenerative Disease Modelling, Research, and Therapeutics
Tirthankar Sen, Rajkumar P. Thummer
Neurotoxicity Research.2022; 40(5): 1597. CrossRef
Encoding type, medication, and deep brain stimulation differentially affect memory-guided sequential reaching movements in Parkinson's disease
Fabian J. David, Yessenia M. Rivera, Tara K. Entezar, Rishabh Arora, Quentin H. Drane, Miranda J. Munoz, Joshua M. Rosenow, Sepehr B. Sani, Gian D. Pal, Leonard Verhagen-Metman, Daniel M. Corcos
Frontiers in Neurology.2022;[Epub] CrossRef
Remote programming for subthalamic deep brain stimulation in Parkinson's disease
Si Chen, Shu-jun Xu, Wei-guo Li, Teng Chen, Chao Li, Shuo Xu, Ning Yang, Yi-ming Liu
Frontiers in Neurology.2022;[Epub] CrossRef
Implementing automation in deep brain stimulation: has the time come?
Marco Bonizzato, Alfonso Fasano
The Lancet Digital Health.2022;[Epub] CrossRef
Longevity of Deep Brain Stimulation Batteries; a Global Survey of Neurosurgeons and Neurologists
Marwan Hariz, Gun‐Marie Hariz, Patric Blomstedt
Movement Disorders.2021; 36(5): 1273. CrossRef
Basic Tips: How Do I Start Programming Deep Brain Stimulation in Parkinson Disease Patients?
Carolina Gorodetsky, Alfonso Fasano
Movement Disorders Clinical Practice.2021; 8(4): 639. CrossRef
Deep brain stimulation: Challenges at the tissue‐electrode interface and current solutions
Emily Kolaya, Bonnie L. Firestein
Biotechnology Progress.2021;[Epub] CrossRef
An Update on Medical and Surgical Treatments of Parkinson’s Disease
Dipali Nemade, Thyagarajan Subramanian, Vikram Shivkumar
Aging and disease.2021; 12(4): 1021. CrossRef
Experimental Characterization of Ferroelectric Capacitor Circuits for the Realization of Simply Designed Electroceuticals
Yves Olsommer, Frank R. Ihmig
Electronic Materials.2021; 2(3): 299. CrossRef
Flexible vs. standard subthalamic stimulation in Parkinson disease: A double-blind proof-of-concept cross-over trial
Derrick Soh, Ricardo Maciel, Musleh Algarni, Karlo Lizarraga, Aaron Loh, Jürgen Germann, Gavin Elias, Alexandre Boutet, Renato P. Munhoz, Suneil K. Kalia, Mojgan Hodaie, Andres M. Lozano, Alfonso Fasano
Parkinsonism & Related Disorders.2021; 89: 93. CrossRef
Telemedicine and Deep brain stimulation - Current practices and recommendations
Vibhash D. Sharma, Delaram Safarpour, Shyamal H. Mehta, Nora Vanegas-Arroyave, Daniel Weiss, Jeffrey W. Cooney, Zoltan Mari, Alfonso Fasano
Parkinsonism & Related Disorders.2021; 89: 199. CrossRef
Subspace-based predictive control of Parkinson’s disease: A model-based study
Mahboubeh Ahmadipour, Mojtaba Barkhordari-Yazdi, Saeid R. Seydnejad
Neural Networks.2021; 142: 680. CrossRef
Advances in Triboelectric Nanogenerators for Self‐Powered Regenerative Medicine
Samira Parandeh, Niloofar Etemadi, Mahshid Kharaziha, Guorui Chen, Ardo Nashalian, Xiao Xiao, Jun Chen
Advanced Functional Materials.2021; 31(47): 2105169. CrossRef
Implantable Pulse Generators for Deep Brain Stimulation: Challenges, Complications, and Strategies for Practicality and Longevity
Can Sarica, Christian Iorio-Morin, David H. Aguirre-Padilla, Ahmed Najjar, Michelle Paff, Anton Fomenko, Kazuaki Yamamoto, Ajmal Zemmar, Nir Lipsman, George M. Ibrahim, Clement Hamani, Mojgan Hodaie, Andres M. Lozano, Renato P. Munhoz, Alfonso Fasano, Sun
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Microstimulation Is a Promising Approach in Achieving Better Lead Placement in Subthalamic Nucleus Deep Brain Stimulation Surgery
Lin Shi, Shiying Fan, Tianshuo Yuan, Huaying Fang, Jie Zheng, Zunyu Xiao, Yu Diao, Guanyu Zhu, Quan Zhang, Huanguang Liu, Hua Zhang, Fangang Meng, Jianguo Zhang, Anchao Yang
Frontiers in Neurology.2021;[Epub] CrossRef
Revisiting brain stimulation in Parkinson’s disease
Carola A. Haas
Science.2021; 374(6564): 153. CrossRef
A New Implantable Closed-Loop Clinical Neural Interface: First Application in Parkinson’s Disease
Mattia Arlotti, Matteo Colombo, Andrea Bonfanti, Tomasz Mandat, Michele Maria Lanotte, Elena Pirola, Linda Borellini, Paolo Rampini, Roberto Eleopra, Sara Rinaldo, Luigi Romito, Marcus L. F. Janssen, Alberto Priori, Sara Marceglia
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Update on Parkinson's Disease Therapy
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Deep Brain Stimulation for Parkinson's Disease: Currents Status and Emerging Concepts
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Original Articles

Parkinson Anxiety Scale: A Validation Study for the Brazilian Population: Renilson Moraes-Ferreira, Wilson Mateus Gomes da Costa Alves, Maysa Alves Rodrigues Brandao-Rangel, Odilon Abrahin, Clebson Pantoja Pimentel, Evitom Correa-Sousa, Rodolfo Paula Vieira, Erik Artur Cortinhas-Alves; J Mov Disord. 2020;13(3):199-204. Published online July 28, 2020; DOI: https://doi.org/10.14802/jmd.20031

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Abstract PDF

Objective
The Parkinson Anxiety Scale (PAS) was developed to measure the severity of anxiety symptoms in patients with Parkinson’s disease (PD), and it has not yet been adapted and validated in Portuguese. Thus, this study evaluated the reliability and validity of a translated and adapted version of the PAS for the Brazilian population of PD patients.
Methods
The Parkinson Anxiety Scale – Brazilian Version (PAS-BV) was completed by 55 patients with PD. The reliability (test-retest reliability, interrater reliability and internal consistency) and construct validity of the PAS-BV were assessed by comparing it with the Beck Anxiety Inventory (BAI), the Parkinson’s Disease Fatigue Scale (PFS) and the Unified Parkinson Disease Rating Scale (UPDRS) part III.
Results
Patients with PD had an average age of 64.51 ± 9.20 years and had PD for an average of 6.98 ± 5.02 years. The reliability of the PAS-BV was 0.83, and the intraclass correlation coefficient (ICC) (retest-test) was 0.88. The scale presented good convergent validity with the BAI (r_s = 0.82, p < 0.05). It also presented good divergent validity with the PFS (r_s = 0.24, p > 0.05) and the UPDRS part II (r_s = -0.10, p > 0.05), part III (r_s = -0.21, p > 0.05), and part IV (r_s = 0.03, p > 0.05), as indicated by the absence of significant correlations. However, there was a significant correlation between the PAS-BV and part I of the UPDRS (r_s = 0.67, p < 0.05).
Conclusion
The PAS-BV presents substantial reliability and validity for patients with PD without dementia.

Citations

Citations to this article as recorded by

Should patients with Parkinson’s disease only visit a neurologist’s office? - a narrative review of neuropsychiatric disorders among people with Parkinson’s disease
Julita Szarpak, Paulina Drożak, Michał Piwoński, Hubert Wróblewski, Justyna Morylowska-Topolska
Current Problems of Psychiatry.2022; 23(4): 220. CrossRef

Therapeutic Effect of Levodopa/Carbidopa/Entacapone on Sleep Disturbance in Patients with Parkinson’s Disease: Kye Won Park, Sungyang Jo, Seung Hyun Lee, Yun Su Hwang, Dagyo Lee, Ho-Sung Ryu, Sun Ju Chung; J Mov Disord. 2020;13(3):205-212. Published online September 9, 2020; DOI: https://doi.org/10.14802/jmd.20055

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Abstract PDF

Objective
To investigate the efficacy of levodopa/carbidopa/entacapone (LCE) at bedtime for treating sleep disturbance in patients with Parkinson’s disease (PD) with motor fluctuations.
Methods
Participants included 128 PD patients with motor fluctuations. All patients were assessed for motor, nonmotor, and sleep-specific symptoms using the United Parkinson’s Disease Rating Scale (UPDRS), the Korean version of the Nonmotor Symptom Scale, the Parkinson’s Disease Sleep Scale (PDSS), the Epworth Sleepiness Scale, and the Rapid Eye Movement Sleep Behavior Disorder Screening Questionnaire (RBDSQ). We compared the baseline characteristics of patients with sleep disturbance (PDSS score < 120) and those without sleep disturbance (PDSS score ≥ 120). Thirty-nine patients with sleep disturbance who agreed to take LCE at bedtime completed 3-month follow-ups. We analyzed changes in the scores of motor, nonmotor, and sleep symptom scales over the 3 months.
Results
PD patients with sleep disturbance were at more advanced disease stages and had more severe motor, nonmotor, and sleep symptoms than those without sleep disturbance. Patients who took LCE at night showed improvements in motor (UPDRS part III, p = 0.007) and sleep symptoms (total PDSS, p < 0.001). Sleep features that benefitted from LCE included not only nocturnal motor components but also insomnia (PDSS items 2 and 3, p = 0.005 and p < 0.001) and rapid eye movement behavior disorder (PDSS item 6, p = 0.002; and RBDSQ, p < 0.001).
Conclusion
The use of LCE at bedtime may be a useful treatment for sleep disturbance in advanced PD patients with motor fluctuations.

Citations

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The Home-Based Sleep Laboratory
Yael Hanein, Anat Mirelman, Anat Mirelman, E. Ray Dorsey, Patrik Brundin, Bastiaan R. Bloem
Journal of Parkinson's Disease.2021; 11(s1): S71. CrossRef
Shudi Pingchan Decoction combined with repetitive transcranial magnetic stimulation in the treatment of Parkinson’s disease with sleep disorders
Qing Ye, Xiqun Chen, Yuqing Hu, Jie Zhou, Chen Gao, Zhenguo Liu
Traditional Medicine and Modern Medicine.2020; 03(02): 85. CrossRef

Brief communications

Effectiveness of Exercise on the Sequence Effect in Parkinson’s Disease: Suk Yun Kang, Young Ho Sohn; J Mov Disord. 2020;13(3):213-217. Published online August 31, 2020; DOI: https://doi.org/10.14802/jmd.20045

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Abstract PDF Supplementary Material

Objective
To determine the benefits of motor training on the sequence effect (SE), an essential component of bradykinesia in Parkinson’s disease (PD).
Methods
Seven patients with de novo PD participated in this study. The patients performed regular pentagon drawing tests and exercises during four visits. The first two visits occurred before the start of medication, and the last two visits occurred at least six months after the start of medication. We assessed the severity of bradykinesia and SE at each visit and compared the results before and after exercise in both the de novo and treatment conditions.
Results
In the de novo condition, the severity of bradykinesia significantly improved after motor training (p = 0.018), but it did not resolve and only showed a trend of improvement after treatment (p = 0.068). The severity of the SE decreased significantly in the drug-naïve condition (p = 0.028) but not after medication (p = 0.273).
Conclusion
Our study suggests that regular motor training may be beneficial for the SE in PD.

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The Effects of Intensive Neurorehabilitation on Sequence Effect in Parkinson's Disease Patients With and Without Freezing of Gait
Alessia Putortì, Michele Corrado, Micol Avenali, Daniele Martinelli, Marta Allena, Silvano Cristina, Valentina Grillo, Luca Martinis, Stefano Tamburin, Mariano Serrao, Antonio Pisani, Cristina Tassorelli, Roberto De Icco
Frontiers in Neurology.2021;[Epub] CrossRef

Deep Brain Stimulation Battery Exhaustion during the COVID-19 Pandemic: Crisis within a Crisis: Vikram Venkappayya Holla, Koti Neeraja, Bharath Kumar Surisetti, Shweta Prasad, Nitish Kamble, Dwarakanath Srinivas, Ravi Yadav, Pramod Kumar Pal; J Mov Disord. 2020;13(3):218-222. Published online August 31, 2020; DOI: https://doi.org/10.14802/jmd.20073

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Abstract PDF

Objective
The novel coronavirus disease (COVID-19) pandemic and public health measures to control it have resulted in unique challenges in the management of patients with deep brain stimulation (DBS). We report our experience with the management of acute worsening of symptoms due to battery exhaustion in 3 patients with DBS.
Methods
Patients with DBS for movement disorders who visited the emergency room due to battery exhaustion during the nationwide lockdown from April to May 2020 were included.
Results
Two patients with subthalamic nucleus-DBS for Parkinson’s disease (PD) and one with globus pallidus interna-DBS for generalized dystonia presented with acute worsening of symptoms due to battery exhaustion. Urgent battery replacement was performed in both patients with PD. The patient with generalized dystonia was managed with medication adjustment as he chose to defer battery replacement.
Conclusion
DBS battery replacement can be an emergency. Decisions regarding DBS battery replacement should be individualized during this COVID-19 pandemic.

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Effects of COVID-19 on Synaptic and Neuronal Degeneration
Mohammed S. Alqahtani, Mohamed Abbas, Mohammad Y. Alshahrani, Khulud Alabdullh, Amjad Alqarni, Fawaz F. Alqahtani, Layal K. Jambi, Adnan Alkhayat
Brain Sciences.2023; 13(1): 131. CrossRef
Needs and Perceptions of Patients With Dystonia During the COVID-19 Pandemic: A Qualitative Framework Analysis of Survey Responses From Italy
Vittorio Rispoli, Matías Eduardo Díaz Crescitelli, Francesco Cavallieri, Francesca Antonelli, Stefano Meletti, Luca Ghirotto, Franco Valzania
Frontiers in Neurology.2022;[Epub] CrossRef
Parkinsonism hyperpyraexia syndrome in Parkinson's disease patients undergoing deep brain stimulation: An indirect consequence of COVID-19 lockdowns
Onanong Phokaewvarangkul, Sasivimol Virameteekul, Roongroj Bhidayasiri
Parkinsonism & Related Disorders.2021; 87: 39. CrossRef
An Investigation Into Miniaturised Closed-Loop DBS Devices
Dean M. Corva, Scott D. Adams, Kevin E. Bennet, Parastoo Hashemi, Michael Berk, Abbas Z. Kouzani
IEEE Transactions on Medical Robotics and Bionics.2021; 3(3): 671. CrossRef
Effects of COVID-19 Lockdown on Movement Disorders Patients With Deep Brain Stimulation: A Multicenter Survey
Carla Piano, Francesco Bove, Tommaso Tufo, Isabella Imbimbo, Danilo Genovese, Alessandro Stefani, Massimo Marano, Antonella Peppe, Livia Brusa, Rocco Cerroni, Francesco Motolese, Enrico Di Stasio, Marianna Mazza, Antonio Daniele, Alessandro Olivi, Paolo C
Frontiers in Neurology.2020;[Epub] CrossRef

Case Reports

Focal Unilateral Palatal Myoclonus Causing Objective Clicking Tinnitus without Uvula Elevation Diagnosed by Concurrent Auscultation: Chindhuri Selvadurai, Sara Maguire Schaefer; J Mov Disord. 2020;13(3):223-224. Published online July 14, 2020; DOI: https://doi.org/10.14802/jmd.20010

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Palatal myoclonus generally entails a visible elevation of the palate and uvula and may be accompanied by myoclonus of other oropharyngeal muscles. A 55-year-old man presented with left ear clicking and hyperacusis. Examination showed arrhythmic left lateral soft palate contraction in the tensor veli palatini region without elevation of the uvula, which correlated with an audible click by auscultation with a stethoscope over the left ear. This is a rare case of focal, unilateral palatal myoclonus without visual uvula elevation with concurrent auscultation, demonstrating the importance of careful examination to detect focal myoclonic contractions.

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Tinnitus
Navdeep Bhamra, Charlotte Juman, Edward Balai
InnovAiT: Education and inspiration for general practice.2021; 14(9): 546. CrossRef

Young-Onset Parkinson’s Disease with Impulse Control Disorder Due to Novel Variants of F-Box Only Protein 7: Dallah Yoo, Ji-Hyun Choi, Jin-Hee Im, Man Jin Kim, Han-Joon Kim, Sung Sup Park, Beomseok Jeon; J Mov Disord. 2020;13(3):225-228. Published online September 9, 2020; DOI: https://doi.org/10.14802/jmd.20026

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Abstract PDF

F-box only protein 7 (FBXO7) is a rare monogenic cause of hereditary Parkinson’s disease (PD) with an autosomal recessive mode of inheritance and a broad spectrum of clinical manifestations. Here, we report a de novo PD patient with onset at the age of 28 with novel compound heterozygous variants in the FBXO7 gene (c.1162C>T, p.Gln388X; c.80G>A, p.Arg27His). The clinical features of the patient were problematic impulse control disorder behaviors and pyromania, and pyramidal signs were negative. We describe the novel pathogenic variants of the FBXO7 gene with detailed clinical pictures to report the expanding genotypes and phenotypes of FBXO7-associated parkinsonism.

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Nearly Abolished Dopamine Transporter Uptake in a Patient With a Novel FBXO7 Mutation
Eun Young Kim, Seon Young Kim, Youngduk Seo, Chaewon Shin
Journal of Movement Disorders.2022; 15(3): 269. CrossRef

Letters to the editor

A New Allelic Variant in the PANK2 Gene in a Patient with Incomplete HARP Syndrome: Myriam Ley Martos, María Jesús Salado Reyes, Rosario Marín Iglesias, Carmen Gutiérrez Moro, Manuel Lubián Gutiérrez, Lorena Estepa Pedregosa; J Mov Disord. 2020;13(3):229-231. Published online July 14, 2020; DOI: https://doi.org/10.14802/jmd.19071

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