Journal of Movement Disorders

Volume 11(3); September 2018

Review Articles

The Relationship between Saccades and Locomotion: Anshul Srivastava, Omar F. Ahmad, Christopher Pham Pacia, Mark Hallett, Codrin Lungu; J Mov Disord. 2018;11(3):93-106. Published online August 9, 2018; DOI: https://doi.org/10.14802/jmd.18018

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Human locomotion involves a complex interplay among multiple brain regions and depends on constant feedback from the visual system. We summarize here the current understanding of the relationship among fixations, saccades, and gait as observed in studies sampling eye movements during locomotion, through a review of the literature and a synthesis of the relevant knowledge on the topic. A significant overlap in locomotor and saccadic neural circuitry exists that may support this relationship. Several animal studies have identified potential integration nodes between these overlapping circuitries. Behavioral studies that explored the relationship of saccadic and gait-related impairments in normal conditions and in various disease states are also discussed. Eye movements and locomotion share many underlying neural circuits, and further studies can leverage this interplay for diagnostic and therapeutic purposes.

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Decreased Saccadic Eye Movement Speed Correlates with Dynamic Balance in Older Adults
Youngsook Bae
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Effects of different virtual reality technology driven dual-tasking paradigms on posture and saccadic eye movements in healthy older adults
Yu Imaoka, Andri Flury, Laura Hauri, Eling D. de Bruin
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Coordination between Eye Movement and Whisking in Head-Fixed Mice Navigating a Plus Maze
Ronny Bergmann, Keisuke Sehara, Sina E. Dominiak, Jens Kremkow, Matthew E. Larkum, Robert N. S. Sachdev
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Deep brain stimulation and eye movements
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Antisaccade, a predictive marker for freezing of gait in Parkinson’s disease and gait/gaze network connectivity
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Response Inhibition Deficits in Women with the FMR1 Premutation are Associated with Age and Fall Risk
Carly Moser, Lyndsay Schmitt, Joseph Schmidt, Amanda Fairchild, Jessica Klusek
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Concomitant improvement in anti-saccade success rate and postural instability gait difficulty after rTMS treatment for Parkinson’s disease
Ken-ichi Okada, Mizuki Takahira, Tomoo Mano, Taichi Uga, Kuni Konaka, Koichi Hosomi, Youichi Saitoh
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Multitasking Compensatory Saccadic Training Program for Hemianopia Patients: A New Approach With 3-Dimensional Real-World Objects
Laura Mena-Garcia, Jose C. Pastor-Jimeno, Miguel J. Maldonado, Maria B. Coco-Martin, Itziar Fernandez, Juan F. Arenillas
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Jingbo Zhao, Robert S. Allison
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Saccade and Fixation Eye Movements During Walking in People With Mild Traumatic Brain Injury
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Clinical and Imaging Features of Multiple System Atrophy: Challenges for an Early and Clinically Definitive Diagnosis: Hirohisa Watanabe, Yuichi Riku, Kazuhiro Hara, Kazuya Kawabata, Tomohiko Nakamura, Mizuki Ito, Masaaki Hirayama, Mari Yoshida, Masahisa Katsuno, Gen Sobue; J Mov Disord. 2018;11(3):107-120. Published online August 9, 2018; DOI: https://doi.org/10.14802/jmd.18020

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Abstract PDF

Multiple system atrophy (MSA) is an adult-onset, progressive neurodegenerative disorder. Patients with MSA show various phenotypes during the course of their illness, including parkinsonism, cerebellar ataxia, autonomic failure, and pyramidal signs. Patients with MSA sometimes present with isolated autonomic failure or motor symptoms/ signs. The median duration from onset to the concomitant appearance of motor and autonomic symptoms is approximately 2 years but can range up to 14 years. As the presence of both motor and autonomic symptoms is essential for the current diagnostic criteria, early diagnosis is difficult when patients present with isolated autonomic failure or motor symptoms/signs. In contrast, patients with MSA may show severe autonomic failure and die before the presentation of motor symptoms/signs, which are currently required for the diagnosis of MSA. Recent studies have also revealed that patients with MSA may show nonsupporting features of MSA such as dementia, hallucinations, and vertical gaze palsy. To establish early diagnostic criteria and clinically definitive categorization for the successful development of disease-modifying therapy or symptomatic interventions for MSA, research should focus on the isolated phase and atypical symptoms to develop specific clinical, imaging, and fluid biomarkers that satisfy the requirements for objectivity, for semi- or quantitative measurements, and for uncomplicated, worldwide availability. Several novel techniques, such as automated compartmentalization of the brain into multiple parcels for the quantification of gray and white matter volumes on an individual basis and the visualization of α-synuclein and other candidate serum and cerebrospinal fluid biomarkers, may be promising for the early and clinically definitive diagnosis of MSA.

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Camila C. Lobo, Guilherme S.O. Wertheimer, Gabriel S. Schmitt, Paula C.A.A.P. Matos, Thiago J.R. Rezende, Joyce M. Silva, Fabrício C. Borba, Fabrício D. Lima, Alberto R.M. Martinez, Orlando G.P. Barsottini, José Luiz Pedroso, Wilson Marques, Marcondes C.
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Original Articles

Individual Therapeutic Singing Program for Vocal Quality and Depression in Parkinson’s Disease: Eun Young Han, Ji Young Yun, Hyun Ju Chong, Kyoung-Gyu Choi; J Mov Disord. 2018;11(3):121-128. Published online August 9, 2018; DOI: https://doi.org/10.14802/jmd.17078

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Abstract PDF Supplementary Material

Objective
Patients with Parkinson’s disease (PD) frequently experience depression associated with voice problems. Singing involves the use of similar muscles and the neural networks associated with vocal function and emotional response. The purpose of this study is to enhance vocal quality and depressive symptoms of patients with PD using individual singing program.
Methods
The Individual Therapeutic Singing Program for PD (ITSP-PD) was conducted by a certified music therapist. In total, nine PD patients with a subjective voice problem or depression participated in 6 sessions over 2 weeks. We measured the Maximum Phonation Time (MPT) via the Praat test, the Voice Handicap Index (VHI), the Voice-Related Quality of Life (V-RQOL) and the Geriatric Depression Scale (GDS).
Results
In total, 8 out of 9 patients completed all the sessions; 6 out of 8 patients participated in the follow-up test after 6 months. A statistically significant change in MPT (p = 0.011) was observed between the pre- and post-tests. The VHI (p = 0.035) and the GDS (p = 0.018) were significantly lower in the post-test. In the pre-, post-, and follow-up tests, the MPT (p = 0.030), V-RQOL (p = 0.008), and GDS (p = 0.009) were significantly changed.
Conclusion
The ITSP-PD based on neurological singing therapy for PD showed therapeutic possibility for vocal function and depression in patients with PD. Our findings suggest the need for a randomized study to examine the continuing positive effects of the ITSP-PD over a longer period of time.

Citations

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Functional data analysis of prosodic prominence in Parkinson’s disease: a pilot study
Lauri Tavi, Nelly Penttilä
Clinical Linguistics & Phonetics.2024; 38(1): 64. CrossRef
Awareness of Dysphagia-Related Complications and Risks and the Importance of Early Intervention in Patients with Parkinson’s Disease: A Qualitative Study
Kaifeng Yao, Lihua Wang, Lihua Zhang, Aderito Seixas
International Journal of Clinical Practice.2023; 2023: 1. CrossRef
Group singing improves both physical and psychological wellbeing in people with and without chronic health conditions: A narrative review
Quinn Campbell, Sally Bodkin-Allen, Nicola Swain
Journal of Health Psychology.2022; 27(8): 1897. CrossRef
Defining the Therapeutic Singing Voice: Further Examination of the Everyday Singing Practices of Music Therapists
Martina C Bingham, Elizabeth K Schwartz, Anthony Meadows
Music Therapy Perspectives.2022; 40(1): 3. CrossRef
Music affects functional brain connectivity and is effective in the treatment of neurological disorders
Luisa Speranza, Salvatore Pulcrano, Carla Perrone-Capano, Umberto di Porzio, Floriana Volpicelli
Reviews in the Neurosciences.2022; 33(7): 789. CrossRef
Acute effects of singing on cardiovascular biomarkers
Kamila Somayaji, Mogen Frenkel, Luai Tabaza, Alexis Visotcky, Tanya Kruse Ruck, Ernest Kwesi Ofori, Michael E. Widlansky, Jacquelyn Kulinski
Frontiers in Cardiovascular Medicine.2022;[Epub] CrossRef
Music Therapy and Parkinson’s Disease: A Systematic Review from 2015–2020
Manuel Joaquín Machado Sotomayor, Víctor Arufe-Giráldez, Gerardo Ruíz-Rico, Rubén Navarro-Patón
International Journal of Environmental Research and Public Health.2021; 18(21): 11618. CrossRef
The use of music as an arts-based method in migrant health research: a scoping review protocol
Fran Garry, Sylvia Murphy Tighe, Anne MacFarlane, Helen Phelan
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Walking the thin white line – managing voice in the older adult
Jacqui Allen, Anna Miles
Speech, Language and Hearing.2019; 22(1): 25. CrossRef
Music Therapy and Music-Based Interventions for Movement Disorders
Kerry Devlin, Jumana T. Alshaikh, Alexander Pantelyat
Current Neurology and Neuroscience Reports.2019;[Epub] CrossRef

Transfer Dysphagia Due to Focal Dystonia: Priyanka Samal, Vinay Goyal, Govind K Makharia, Chandan J Das, Sankar Prasad Gorthi, Vishnu V Y, Mamta Bhushan Singh, M V Padma Srivastava; J Mov Disord. 2018;11(3):129-132. Published online September 30, 2018; DOI: https://doi.org/10.14802/jmd.17081

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Abstract PDF Supplementary Material

Objective
The inability to propel a bolus of food successfully from the posterior part of the oral cavity to the oropharynx is defined as transfer dysphagia. The present case series describes the varied presentation of transfer dysphagia due to focal dystonia and highlights the importance of early detection by following up on strong suspicions.
Methods
We describe seven cases of transfer dysphagia due to focal dystonia. Transfer dysphagia as a form of focal dystonia may appear as the sole presenting complaint or may present with other forms of focal dystonia.
Results
Four out of seven patients had pure transfer dysphagia and had previously been treated for functional dysphagia. A high index of suspicion, barium swallow including videofluoroscopy, associated dystonia in other parts of the body and response to drug therapy with trihexyphenidyl/tetrabenazine helped to confirm the diagnosis.
Conclusion
Awareness of these clinical presentations among neurologists and non-neurologists can facilitate an early diagnosis and prevent unnecessary investigations.

Citations

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EXCESSIVE CRYING IN CHILDREN WITH CEREBRAL PALSY AND COMMUNICATION DEFICITS
Nagabhushana Rao Potharaju
GLOBAL JOURNAL FOR RESEARCH ANALYSIS.2022; : 25. CrossRef
Oro-Pharyngeal Dysphagia in Parkinson’s Disease and Related Movement Disorders
Miseon Kwon, Jae-Hong Lee
Journal of Movement Disorders.2019; 12(3): 152. CrossRef

Musculoskeletal Problems Affect the Quality of Life of Patients with Parkinson’s Disease: Young Eun Kim, Han-Joon Kim, Ji Young Yun, Woong-Woo Lee, Hui-Jun Yang, Jong-Min Kim, Beomseok Jeon; J Mov Disord. 2018;11(3):133-138. Published online September 30, 2018; DOI: https://doi.org/10.14802/jmd.18022

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Abstract PDF

Objective
Musculoskeletal problems are more common in patients with Parkinson’s disease (PD) than in normal elderly, but the impact of musculoskeletal problems on health-related quality of life (HRQoL) in patients with PD is unknown.
Methods
Four hundred consecutive patients with PD were enrolled for the evaluation of musculoskeletal problems and HRQoL. HRQoL was assessed by the 36-Item Short Form Health Survey, which comprised physical health and mental health.
Results
Of the total patients, 265 patients had musculoskeletal problems, and 135 patients did not have musculoskeletal problems. Patients with musculoskeletal problems reported lower levels of HRQoL in terms of physical health than did patients without musculoskeletal problems (p < 0.05). In women, all components of physical health were lower in patients with musculoskeletal problems than in patients without musculoskeletal problems (p < 0.05). Meanwhile, in men, only the bodily pain score of physical health was lower in patients with musculoskeletal problems than in patients without musculoskeletal problems. Mental health and physical health were negatively correlated with depression, Unified Parkinson’s Disease Rating Scale I & II scores, and pain severity from musculoskeletal problems, in that order (p < 0.01 for all).
Conclusion
These results suggest that musculoskeletal problems in patients with PD affect HRQoL significantly, mainly in terms of physical health rather than mental health and especially in women rather than men. Musculoskeletal problems should not be overlooked in the care of patients with PD.

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Assessments scales for the evaluation of health-related quality of life in Parkinson's disease, progressive supranuclear palsy, and multiple system atrophy: a systematic review
Maria Lucia Maiuolo, Roberto Giorgini, Maria Grazia Vaccaro, Alessio Facchin, Andrea Quattrone, Aldo Quattrone
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Guangchen Sun, Hui Yu, Jun Cui, Ming Li, Yuefang Ru
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Quality of life of older adults in two contrasting neighbourhoods in Accra, Ghana
Dominic A. Alaazi, Devidas Menon, Tania Stafinski, Stephen Hodgins, Gian Jhangri
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Bogumiła Pniak, Justyna Leszczak, Jadwiga Kurczab, Aleksandra Krzemińska, Joanna Pięta, Agnieszka Plis, Ewelina Czenczek-Lewandowska, Agnieszka Guzik
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Sex-specific effects of subthalamic nucleus stimulation on pain in Parkinson’s disease
Olga Khazen, Marisa DiMarzio, Kelsey Platanitis, Heather C. Grimaudo, Maria Hancu, Miriam M. Shao, Michael D. Staudt, Lucy Maguire, Vishad V. Sukul, Jennifer Durphy, Era K. Hanspal, Octavian Adam, Eric Molho, Julie G. Pilitsis
Journal of Neurosurgery.2021; 135(2): 629. CrossRef
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Yi-Cheng Tai, Chin-Hsien Lin
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Ji-Hyun Choi, Jong-Min Kim, Hee Kyung Yang, Hyo-Jung Lee, Cheol Min Shin, Seong Jin Jeong, Won-Seok Kim, Ji Won Han, In-Young Yoon, Yoo Sung Song, Yun Jung Bae
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Parkinson's Disease Is Associated with Increased Complications, Readmission Rates, and Costs of Care after Total Hip Arthroplasty: A Matched-Cohort Analysis
Simon Katz, Kevin B. Marchand, Rushabh M. Vakharia, Hiba Anis, Nipun Sodhi, Nicolas S. Piuzzi, Michael A. Mont, Martin W. Roche
The Journal of Hip Surgery.2020; 4(03): 149. CrossRef
Chronic Pain Treatment Strategies in Parkinson’s Disease
Amber Edinoff, Niro Sathivadivel, Timothy McBride, Allyson Parker, Chikezie Okeagu, Alan D. Kaye, Adam M. Kaye, Jessica S. Kaye, Rachel J. Kaye, Meeta M. Sheth, Omar Viswanath, Ivan Urits
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Cognition, Olfaction and Uric Acid in Early de novo Parkinson’s Disease: Hwa Reung Lee, Joong Hyun Park, Sang Won Han, Jong Sam Baik; J Mov Disord. 2018;11(3):139-144. Published online September 30, 2018; DOI: https://doi.org/10.14802/jmd.18037

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Abstract PDF

Objective
Cognitive impairment is one of the nonmotor symptoms in Parkinson’s disease (PD), and olfactory dysfunction is used as a marker to detect premotor stages of PD. Serum uric acid (sUA) levels have been found to be a risk factor for PD. Our objective in this study was to examine whether sUA levels are associated with cognitive changes and olfactory dysfunction in early de novo PD patients.
Methods
The study participants included 196 de novo PD patients. We assessed cognitive function by the Korean versions of the Mini-Mental State Examination and the Montreal Cognitive Assessment and assessed olfactory function by the Korean version of the Sniffin’ Sticks test.
Results
The mean sUA level was 4.7 mg/dL and was significantly lower in women than in men. Cognitive scores were lower in women, suggesting that sUA levels were related to cognitive function. The olfactory functions were not related to sUA level but were clearly associated with cognitive scores. Olfactory threshold, odor discrimination, and odor identification were all significantly related to cognitive scores.
Conclusion
We conclude that lower sUA levels were associated with cognitive impairment, not olfactory dysfunction, in de novo PD patients. This finding suggests that UA is neuroprotective as an antioxidant in the cognitive function of PD patients.

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Per Borghammer, Mie Kristine Just, Jacob Horsager, Casper Skjærbæk, Anna Raunio, Eloise H. Kok, Sara Savola, Shigeo Murayama, Yuko Saito, Liisa Myllykangas, Nathalie Van Den Berge
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What substance P might tell us about the prognosis and mechanism of Parkinson's disease?
Paola Tirassa, Tommaso Schirinzi, Marcello Raspa, Massimo Ralli, Antonio Greco, Antonella Polimeni, Roberta Possenti, Nicola Biagio Mercuri, Cinzia Severini
Neuroscience & Biobehavioral Reviews.2021; 131: 899. CrossRef
Brain-First versus Gut-First Parkinson’s Disease: A Hypothesis
Per Borghammer, Nathalie Van Den Berge, Teus van Laar
Journal of Parkinson's Disease.2019; 9(s2): S281. CrossRef

Case Report

A Patient with Myotonic Dystrophy Type 1 Presenting as Parkinsonism: Ji-Hyun Choi, Jee-Young Lee, Han-Joon Kim, Beomseok Jeon; J Mov Disord. 2018;11(3):145-148. Published online September 30, 2018; DOI: https://doi.org/10.14802/jmd.18028

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Abstract PDF: The current body of literature contains 5 reports of myotonic dystrophy (DM) with parkinsonism: 4 reports of DM type 2 and 1 report of clinically suspected DM type 1. To date, there have been no genetically proven cases of DM type 1 with parkinsonism. Here, we report the first case of genetically proven DM type 1 and parkinsonism that developed ahead of muscle symptoms with bilateral putaminal, presynaptic dopaminergic deficits on imaging. A 54-year-old female patient presented with bradykinesia, axial and bilateral limb rigidity, stooped posture, and hypomimia, which did not respond to levodopa. At age 56, she developed neck flexion weakness. Examination showed bilateral facial weakness, percussion and grip myotonia, and electromyography confirmed myotonic discharges. A genetic study of DM type 1 showed a DMPK mutation. At age 58, gait freezing, postural instability, and frequent falling developed and did not respond to increasing doses of levodopa. At age 59, the patient died from asphyxia.

Letter to the editor

Chorea in Sporadic Creutzfeldt-Jakob Disease: Ai Huey Tan, Tsun Haw Toh, Soon Chai Low, Si Lei Fong, Kah Kian Chong, Kee Wei Lee, Khean Jin Goh, Shen-Yang Lim; J Mov Disord. 2018;11(3):149-151. Published online August 9, 2018; DOI: https://doi.org/10.14802/jmd.18017

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Citations

Citations to this article as recorded by

Parkinsonism as an initial presentation of Creutzfeldt‐Jakob disease: A case report and review of literature
Sahar Nikkhah Bahrami, Asal Sadat Karimi, Sepehr Khosravi, Mostafa Almasi‐Dooghaee
Clinical Case Reports.2024;[Epub] CrossRef
Atypical and early symptoms of sporadic Creutzfeldt – Jakob disease: case series and review of the literature
Grammatiki Katsikaki, Ioannis E. Dagklis, Petros Angelopoulos, Dimitrios Ntantos, Angeliki Prevezianou, Sevasti Bostantjopoulou
International Journal of Neuroscience.2021; 131(9): 927. CrossRef
Review of Hereditary and Acquired Rare Choreas
Daniel Martinez-Ramirez, Ruth H. Walker, Mayela Rodríguez-Violante, Emilia M. Gatto
Tremor and Other Hyperkinetic Movements.2020;[Epub] CrossRef
A Case of Creutzfeldt-Jakob Disease Presented as Rapid Progressive Parkinsonism
Yoonah Park, Chan-Nyeong Lee
Dementia and Neurocognitive Disorders.2019; 18(4): 152. CrossRef

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