Journal of Movement Disorders

Young Hee Sung

2 Articles

Rapid Eye Movement Sleep Behavior Disorder in Parkinson’s Disease: A Preliminary Study: Chang Soo Kim, Young Hee Sung, Min Ju Kang, Kee Hyung Park; J Mov Disord. 2016;9(2):114-119. Published online March 2, 2016; DOI: https://doi.org/10.14802/jmd.15039

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Objective
Rapid eye movement sleep behavior disorder (RBD) is associated with α-synucleinopathies, such as Parkinson’s disease (PD). We aimed to assess the differences in the clinical characteristics of PD with and without RBD.
Methods
Forty-two patients previously diagnosed with PD were evaluated for clinical history, motor and cognitive functioning using the Unified Parkinson’s Disease Rating Scale (UPDRS) and Mini-Mental State Examination (MMSE), autonomic symptoms, sleep characteristics using the Pittsburg Sleep Quality Index (PSQI), and the presence of RBD using the Korean version of the RBD screening questionnaire (RBDSQ). The prevalence of RBD and the patients’ demographic features were evaluated. The patients were classified into two groups, PD with RBD and PD without RBD, based on the RBDSQ scores. The motor and cognitive functions, as well as other clinical features of the two groups were compared.
Results
A total of 42 PD patients were enrolled. Eighteen patients were classified as PD with RBD. Compared to PD without RBD, PD with RBD showed higher scores of rigidity in the UPDRS subscale. Regarding sleep problems, PD with RBD revealed higher sleep disturbance, lower sleep efficiency, and lower overall sleep quality in the PSQI. There was no difference in cognitive dysfunction between the two groups according to the Korean version of the MMSE.
Conclusions
PD with RBD was associated with poorer sleep and motor symptoms. Therefore, RBD symptoms in PD are possibly poor prognostic markers.

Citations

Citations to this article as recorded by

Cerebellar Microstructural Abnormalities in Parkinson’s Disease: a Systematic Review of Diffusion Tensor Imaging Studies
Maryam Haghshomar, Parnian Shobeiri, Seyed Arsalan Seyedi, Fatemeh Abbasi-Feijani, Amirhossein Poopak, Houman Sotoudeh, Arash Kamali, Mohammad Hadi Aarabi
The Cerebellum.2022; 21(4): 545. CrossRef
A data-driven system to identify REM sleep behavior disorder and to predict its progression from the prodromal stage in Parkinson's disease
Matteo Cesari, Julie A.E. Christensen, Maria-Lucia Muntean, Brit Mollenhauer, Friederike Sixel-Döring, Helge B.D. Sorensen, Claudia Trenkwalder, Poul Jennum
Sleep Medicine.2021; 77: 238. CrossRef
Impact of Obstructive Sleep Apnea on Cognitive and Motor Functions in Parkinson's Disease
Mohamed Elfil, Eshak I. Bahbah, Mahmoud M. Attia, Mohamed Eldokmak, Brian B. Koo
Movement Disorders.2021; 36(3): 570. CrossRef
Sleep Disorders and Cognitive Dysfunctions in Parkinson’s Disease: A Meta-Analytic Study
Gianpaolo Maggi, Luigi Trojano, Paolo Barone, Gabriella Santangelo
Neuropsychology Review.2021; 31(4): 643. CrossRef
Risk stratification for REM sleep behavior disorder in patients with Parkinson’s disease: A PRISMA-compliant meta-analysis and systematic review
Chengjuan Xie, Mingyu Zhu, Ying Hu
Clinical Neurology and Neurosurgery.2021; 202: 106484. CrossRef
REM sleep behavior disorder portends poor prognosis in Parkinson’s disease: A systematic review
Yoon Kim, Young Eun Kim, Eun Ok Park, Chae Won Shin, Han-Joon Kim, Beomseok Jeon
Journal of Clinical Neuroscience.2018; 47: 6. CrossRef
Prevalence of rapid eye movement sleep behavior disorder (RBD) in Parkinson’s disease: a meta and meta-regression analysis
Xiaona Zhang, Xiaoxuan Sun, Junhong Wang, Liou Tang, Anmu Xie
Neurological Sciences.2017; 38(1): 163. CrossRef
Clinical variations in Parkinson’s disease patients with or without REM sleep behaviour disorder: a meta-analysis
Ruo-lin Zhu, Cheng-juan Xie, Pan-pan Hu, Kai Wang
Scientific Reports.2017;[Epub] CrossRef

Correlation of Sleep Disturbance and Cognitive Impairment in Patients with Parkinson’s Disease: Eun Ja Kim, Joon Hyun Baek, Dong Jin Shin, Hyeon-Mi Park, Yeong-Bae Lee, Kee-Hyung Park, Dong Hoon Shin, Young Noh, Young Hee Sung; J Mov Disord. 2014;7(1):13-18. Published online April 30, 2014; DOI: https://doi.org/10.14802/jmd.14003

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107 Download
10 Citations

Abstract PDF

Objective: Cognitive impairment is a common nonmotor symptom of Parkinson’s disease (PD) and is associated with high mortality, caregiver distress, and nursing home placement. The risk factors for cognitive decline in PD patients include advanced age, longer disease duration, rapid eye movement sleep behavior disorder, hallucinations, excessive daytime sleepiness, and nontremor symptoms including bradykinesia, rigidity, postural instability, and gait disturbance. We conducted a cross-sectional study to determine which types of sleep disturbances are related to cognitive function in PD patients.
Methods: A total of 71 PD patients (29 males, mean age 66.46 ± 8.87 years) were recruited. All patients underwent the Mini- Mental State Examination (MMSE) and the Korean Version of the Montreal Cognitive Assessments (MoCA-K) to assess global cognitive function. Sleep disorders were evaluated with the Stanford Sleepiness Scale, Epworth Sleepiness Scale, Insomnia Severity Index (ISI), Pittsburg Sleep Quality Index, and Parkinson’s Disease Sleep Scale in Korea (PDSS).
Results: The ISI was correlated with the MMSE, and total PDSS scores were correlated with the MMSE and the MoCA-K. In each item of the PDSS, nocturnal restlessness, vivid dreams, hallucinations, and nocturnal motor symptoms were positively correlated with the MMSE, and nocturnal restlessness and vivid dreams were significantly related to the MoCA-K. Vivid dreams and nocturnal restlessness are considered the most powerful correlation factors with global cognitive function, because they commonly had significant correlation to cognition assessed with both the MMSE and the MoCA-K.

Conclusions: We found a correlation between global cognitive function and sleep disturbances, including vivid dreams and nocturnal restlessness, in PD patients.

Citations

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Frontiers in Neurology.2022;[Epub] CrossRef
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Movement Disorders Clinical Practice.2021; 8(7): 1041. CrossRef
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Neuroscience Letters.2019; 699: 71. CrossRef
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Bruno T. Junho, Arthur Kummer, Francisco E. Cardoso, Antonio L. Teixeira, Natalia P. Rocha
Acta Neurologica Belgica.2018; 118(1): 85. CrossRef
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Jade Q. Wu, Peng Li, Karina Stavitsky Gilbert, Kun Hu, Alice Cronin‐Golomb
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Sleep Disturbance May Alter White Matter and Resting State Functional Connectivities in Parkinson’s Disease
Seok Jong Chung, Yong-Ho Choi, Hunki Kwon, Yeong-Hun Park, Hyuk Jin Yun, Han Soo Yoo, Seock Hyeon Moon, Byoung Seok Ye, Young H. Sohn, Jong-Min Lee, Phil Hyu Lee
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