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Toshiaki Wasaka 1 Article
The Sequence Effect in De Novo Parkinson’s Disease
Suk Yun Kang, Toshiaki Wasaka, Ejaz A. Shamim, Sungyoung Auh, Yoshino Ueki, Nguyet Dang, Mark Hallett
J Mov Disord. 2011;4(1):38-40.
DOI: https://doi.org/10.14802/jmd.11006
  • 11,392 View
  • 52 Download
  • 10 Citations
AbstractAbstract PDF
Background and Purpose

The sequence effect (SE) in Parkinson’s disease (PD) denotes progressive slowness in speed or progressive decrease in amplitude of repetitive movements. It is a well-known feature of bradykinesia and is considered unique in PD. Until now, it was well-documented in advanced PD, but not in drug-naïve PD. The aim of this study is to know whether the SE can also be measured in drug-naïve PD.

Methods

We measured the SE with a computer-based, modified Purdue pegboard in 4 drug-naïve PD patients, which matched our previous study with advanced PD patients.

Results

We observed progressive slowness during movement, that is, SE. Statistical analysis showed a strong statistical trend toward the SE with the right hand, but no significance with the left hand. There was no statistical significance of SE with either the more or less affected hands.

Conclusions

These results indicate that the SE can be identified in drug-naïve PD, as well as in advanced PD, with objective measurements and support the idea that the SE is a feature in PD observed during the early stage of the disease without medication.

Citations

Citations to this article as recorded by  
  • Neurofeedback-guided kinesthetic motor imagery training in Parkinson’s disease: Randomized trial
    Sule Tinaz, Serageldin Kamel, Sai S. Aravala, Mohamed Elfil, Ahmed Bayoumi, Amar Patel, Dustin Scheinost, Rajita Sinha, Michelle Hampson
    NeuroImage: Clinical.2022; 34: 102980.     CrossRef
  • The Pathophysiological Correlates of Parkinson's Disease Clinical Subtypes
    Daniele Belvisi, Andrea Fabbrini, Maria Ilenia De Bartolo, Matteo Costanzo, Nicoletta Manzo, Giovanni Fabbrini, Giovanni Defazio, Antonella Conte, Alfredo Berardelli
    Movement Disorders.2021; 36(2): 370.     CrossRef
  • The Effects of Intensive Neurorehabilitation on Sequence Effect in Parkinson's Disease Patients With and Without Freezing of Gait
    Alessia Putortì, Michele Corrado, Micol Avenali, Daniele Martinelli, Marta Allena, Silvano Cristina, Valentina Grillo, Luca Martinis, Stefano Tamburin, Mariano Serrao, Antonio Pisani, Cristina Tassorelli, Roberto De Icco
    Frontiers in Neurology.2021;[Epub]     CrossRef
  • Evolving concepts on bradykinesia
    Matteo Bologna, Giulia Paparella, Alfonso Fasano, Mark Hallett, Alfredo Berardelli
    Brain.2020; 143(3): 727.     CrossRef
  • Effectiveness of Exercise on the Sequence Effect in Parkinson’s Disease
    Suk Yun Kang, Young Ho Sohn
    Journal of Movement Disorders.2020; 13(3): 213.     CrossRef
  • Neurophysiological correlates of bradykinesia in Parkinson’s disease
    Matteo Bologna, Andrea Guerra, Giulia Paparella, Laura Giordo, Danilo Alunni Fegatelli, Anna Rita Vestri, John C Rothwell, Alfredo Berardelli
    Brain.2018; 141(8): 2432.     CrossRef
  • Insula as the Interface Between Body Awareness and Movement: A Neurofeedback-Guided Kinesthetic Motor Imagery Study in Parkinson’s Disease
    Sule Tinaz, Kiran Para, Ana Vives-Rodriguez, Valeria Martinez-Kaigi, Keerthana Nalamada, Mine Sezgin, Dustin Scheinost, Michelle Hampson, Elan D. Louis, R. Todd Constable
    Frontiers in Human Neuroscience.2018;[Epub]     CrossRef
  • Sequence Effect in Parkinson’s Disease Is Related to Motor Energetic Cost
    Sule Tinaz, Ajay S. Pillai, Mark Hallett
    Frontiers in Neurology.2016;[Epub]     CrossRef
  • Bradykinesia in early and advanced Parkinson's disease
    Matteo Bologna, Giorgio Leodori, Paola Stirpe, Giulia Paparella, Donato Colella, Daniele Belvisi, Alfonso Fasano, Giovanni Fabbrini, Alfredo Berardelli
    Journal of the Neurological Sciences.2016; 369: 286.     CrossRef
  • Neural correlates of progressive reduction of bradykinesia in de novo Parkinson's disease
    Eeksung Lee, Ji Eun Lee, Kwangsun Yoo, Jin Yong Hong, Jungsu Oh, Mun Kyung Sunwoo, Jae Seung Kim, Yong Jeong, Phil Hyu Lee, Young Ho Sohn, Suk Yun Kang
    Parkinsonism & Related Disorders.2014;[Epub]     CrossRef

JMD : Journal of Movement Disorders