- Lateralized Effects of Unilateral Thalamotomy and Thalamic Stimulation in Patients with Essential Tremor
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Mi J. Kim, Sang R. Jeon, Sung R. Kim, Myoung C. Lee, Sun J. Chung
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J Mov Disord. 2011;4(2):64-67.
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DOI: https://doi.org/10.14802/jmd.11013
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 Abstract
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Background and Purpose
Stereotactic thalamotomy has been an effective surgical procedure in the treatment of medically refractory essential tremor (ET), however, little is known about the bilateral effects of unilateral ventralis intermedius (Vim) thalamotomy and Vim deep brain stimulation (DBS). We studied the lateralized effects of unilateral Vim thalamotomy and Vim DBS in ET patients.
Methods
Vim thalamotomy was performed in 6 patients and Vim DBS in 6. Patients were evaluated preoperatively and at 3 and 6 months postoperatively using the Clinical Rating Scale for Tremor (CRST).
Results
The contralateral Part A (tremor localization/severity rating) and Part B (specific motor tasks/function rating) subscores, and axial subscores of CRST significantly improved after unilateral Vim thalamotomy or Vim DBS. On the side ipsilateral to surgery, ET patients demonstrated no significant improvements in the Part A and Part B subscores of CRST. The Part C (functional disabilities resulting from tremor) subscores and total scores of CRST were significantly improved after surgery.
Conclusions
Vim thalamotomy and DBS may be equally effective for the management of contralateral and axial tremor in ET patients, but both interventions may not improve tremor on the side ipsilateral to surgery.
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Citations
Citations to this article as recorded by  - Outcomes of stereotactic thalamotomy in patients of essential tremor: A systematic review
Sagun Ghimire, Bibechan Thapa, Durga Neupane, Pashupati Pokharel
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Frontiers in Neurology.2023;[Epub] CrossRef - Commentary on: A Network Approach to Understanding the Effects of Focused Ultrasound for Essential Tremor: Insights into Pathophysiology, Treatment, and Imaging Biomarkers
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Neurotherapeutics.2022; 19(6): 1883. CrossRef - Deep Brain Stimulation for Tremor: Update on Long-Term Outcomes, Target Considerations and Future Directions
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Journal of Clinical Medicine.2021; 10(16): 3468. CrossRef - Clinical improvement associated with targeted interruption of the cerebellothalamic tract following MR-guided focused ultrasound for essential tremor
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Lauren K. Dunn, Marcel E. Durieux, W. Jeffrey Elias, Edward C. Nemergut, Bhiken I. Naik
Journal of Neurosurgical Anesthesiology.2018; 30(1): 18. CrossRef - Surgical treatments for essential tremor
Rodger J. Elble, Ludy Shih, Jeffrey W. Cozzens
Expert Review of Neurotherapeutics.2018; 18(4): 303. CrossRef - The Current Status of Deep Brain Stimulation for the Treatment of Parkinson Disease in the Republic of Korea
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Journal of Movement Disorders.2015; 8(3): 115. CrossRef
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