Journal of Movement Disorders

Seong-Beom Koh

18 Articles

Validity and Reliability of the Korean-Translated Version of the International Cooperative Ataxia Rating Scale in Cerebellar Ataxia: Jinse Park, Jin Whan Cho, Jinyoung Youn, Engseok Oh, Wooyoung Jang, Joong-Seok Kim, Yoon-Sang Oh, Hyungyoung Hwang, Chang-Hwan Ryu, Jin-Young Ahn, Jee-Young Lee, Seong-Beom Koh, Jae H. Park, Hee-Tae Kim; J Mov Disord. 2023;16(1):86-90. Published online December 20, 2022; DOI: https://doi.org/10.14802/jmd.22137

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Abstract PDF Supplementary Material: Objective
The International Cooperative Ataxia Rating Scale (ICARS) is a semiquantitative clinical scale for ataxia that is widely used in numerous countries. The purpose of this study was to investigate the validity and reliability of the Korean-translated version of the ICARS.
Methods
Eighty-eight patients who presented with cerebellar ataxia were enrolled. We investigated the construct validity using exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). We also investigated the internal consistency using Cronbach’s α and intrarater and interrater reliability using intraclass correlation coefficients.
Results
The Korean-translated ICARS showed satisfactory construct validity using EFA and CFA. It also revealed good interrater and intrarater reliability and showed acceptable internal consistency. However, subscale 4 for assessing oculomotor disorder showed moderate internal consistency.
Conclusion
This is the first report to investigate the validity and reliability of the Korean-translated ICARS. Our results showed excellent construct and convergent validity. The reliability is also acceptable.

Dance Intervention Using the Feldenkrais Method Improves Motor, and Non-Motor Symptoms and Gait in Parkinson’s Disease: A 12-Month Study: Sung Hoon Kang, Jinhee Kim, Ilsoo Kim, Young Ae Moon, Sojung Park, Seong-Beom Koh; J Mov Disord. 2022;15(1):53-57. Published online November 3, 2021; DOI: https://doi.org/10.14802/jmd.21086

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Objective
The aim of this study was to assess the effects of dancing (using the Feldenkrais method) on motor and non-motor symptoms, quality of life (QoL), and objective parameters of gait at the time of intervention and at the end of the 1-year study period.
Methods
This was a single-arm study in which 12 subjects with Parkinson’s disease (PD) received dance intervention during a 6-month period. Objective motor scales, gait analysis, and questionnaires on non-motor symptoms were evaluated at baseline and at 3, 6, and 12 months.
Results
Dance intervention decreased motor scale (Unified Parkinson’s Disease Rating Scale and Tinetti scale) scores and improved gait disturbance (gait velocity and step length) without increasing levodopa equivalent dose. Furthermore, dancing decreased non-motor scale (Non-Motor Symptoms Scale and Montgomery-Asberg Depression Rating Scale) scores and improved QoL.
Conclusion
Our findings suggest that dance intervention can be a complementary management method for PD patients.

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Mild cognitive impairment is associated with poor gait performance in patients with Parkinson’s disease
Sung Hoon Kang, Jinhee Kim, Jungyeun Lee, Seong-Beom Koh
Frontiers in Aging Neuroscience.2022;[Epub] CrossRef

Constipation is Associated With Mild Cognitive Impairment in Patients With de novo Parkinson’s Disease: Sung Hoon Kang, Jungyeun Lee, Seong-Beom Koh; J Mov Disord. 2022;15(1):38-42. Published online November 17, 2021; DOI: https://doi.org/10.14802/jmd.21074

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Objective
The association between gastrointestinal (GI) symptoms and cognitive profile in patients with Parkinson’s disease (PD) at diagnosis remains unclear, although GI symptoms and cognitive impairment are highly prevalent in patients with PD. We investigated the relationship between constipation and cognitive status. We also aimed to identify the correlation between constipation and each neuropsychological dysfunction.
Methods
A total of 427 patients with de novo Parkinson’s disease with normal cognition (PD-NC, n = 170) and Parkinson’s disease with mild cognitive impairment (PD-MCI, n = 257) at Korea University Guro Hospital in Seoul, Korea were included. All patients underwent comprehensive neuropsychological tests and completed the Non-Motor Symptoms Scale (NMSS). The frequency and severity of constipation were assessed using the NMSS GI symptoms scale, we used logistic regression analysis and partial correlation analysis to determine the associations between constipation score, MCI, and each neuropsychological dysfunction.
Results
Frequent and severe constipation was associated with MCI in patients with PD at diagnosis regardless of disease severity. Specifically, constipation was related to poor performance in frontal-executive and visuospatial functions after controlling for age and sex.
Conclusion
Our findings may provide an understanding of constipation as a marker associated with cognitive impairment in individuals with PD. Therefore, the evaluation of cognitive function is warranted in PD patients with constipation, while further studies are necessary to investigate the detailed mechanism of our results.

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Interactions between gut microbiota and Parkinson's disease: The role of microbiota-derived amino acid metabolism
Wang Wang, Shujun Jiang, Chengcheng Xu, Lili Tang, Yan Liang, Yang Zhao, Guoxue Zhu
Frontiers in Aging Neuroscience.2022;[Epub] CrossRef

The Four Square Step Test for Assessing Cognitively Demanding Dynamic Balance in Parkinson’s Disease Patients: Jinhee Kim, Ilsoo Kim, Ye Eun Kim, Seong-Beom Koh; J Mov Disord. 2021;14(3):208-213. Published online May 26, 2021; DOI: https://doi.org/10.14802/jmd.20146

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Objective
The Four Square Step Test (FSST) is a tool that assesses dynamic balance during obstacle step-over. To date, few studies have used the FSST to measure balance in patients with Parkinson’s disease (PD). This study aimed to verify that patients with PD, even at the de novo early stage, take more time to perform the FSST and identify which factors, cognitive status or cardinal motor symptoms, are related most to FSST scores.
Methods
Thirty-five newly diagnosed drug-naïve patients with PD and 17 controls completed the FSST. The Unified Parkinson’s Disease Rating Scale (UPDRS), Hoehn and Yahr (H&Y) stage, spatiotemporal gait parameters, and neuropsychological test battery were also assessed in the PD group.
Results
Mean FSST performance time was 8.20 ± 1.61 seconds in patients with PD, which was significantly more than the control group (7.13 ± 1.10 seconds, p = 0.018). UPDRS part III total score and H&Y stage were not significantly associated with FSST, but among the UPDRS subscores, only the postural instability/gait disturbance subscore showed a significant association. Regarding the association between FSST and cognition, the Trail Making Test-B and the Color Word Stroop Test showed strongly inverse correlations with FSST (rho = -0.598 and -0.590, respectively). With respect to gait parameters, double support time was significantly associated with FSST score (rho = 0.342, p = 0.044); however, other parameters, including velocity and step length, were not associated with the FSST.
Conclusion
The FSST can be used in the clinic to assess dynamic balance with cognitive demands even in the early stages of PD.

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Relationship between parental history of dementia, motor-cognitive and executive function performance in African American women
Allison A. Bay, Nicole Schindler, Whitney Wharton, Hayley Silverstein, Liang Ni, Todd A. Prusin, Madeleine E. Hackney
Journal of the Neurological Sciences.2022; 439: 120305. CrossRef

Clinical Characteristics of Involuntary Movement in Hospitalized Patients: Kyum-Yil Kwon, Hye Mi Lee, Seon-Min Lee, Seong-Beom Koh; J Mov Disord. 2019;12(1):31-36. Published online December 20, 2018; DOI: https://doi.org/10.14802/jmd.18040

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Objective
Neurological symptoms in hospitalized patients are not rare, and neurological consultation for movement disorders is especially important in evaluating or managing those with various movement disorders. Therefore, we investigated a clinical pattern of in-hospital consultations for various movement disorders in a tertiary care university hospital.
Methods
Over two years, a total of 202 patients (70.7 ± 11.8 years of age) presenting with movement disorders referred to movement disorder specialists were investigated.
Results
The main symptoms referred by nonneurologists were tremor (56.9%), parkinsonism (16.8%), and gait disturbance (8.9%). The most frequent diagnostic category was toxic/metabolic-caused movement disorder (T/MCMD) (35%) with regard to medications, followed by Parkinson’s disease (PD) (16%). Regarding the mode of onset, T/MCMD was the leading cause for acute (68%) and subacute onset (46%), while PD was the leading disorder (31%) for chronic onset.
Conclusion
The current study showed a characteristic pattern of inpatients presenting with movement disorders. Furthermore, our findings highlighted the clinical significance of drug use or metabolic problems for treating this patient population.

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Clinical Spectrum of Movement Disorders in Neurology Inpatients in a Tertiary Care Centre
Shabeer Ahmad Paul, Gouranga Prasad Mondal, Ramesh Bhattacharyya, Kartik Chandra Ghosh, Sarbajit Das, Suman Das, Hema Krishna, Chandrakanta Patra
Journal of Neurosciences in Rural Practice.2021; 12: 581. CrossRef

Validity and Reliability Study of the Korean Tinetti Mobility Test for Parkinson’s Disease: Jinse Park, Seong-Beom Koh, Hee Jin Kim, Eungseok Oh, Joong-Seok Kim, Ji Young Yun, Do-Young Kwon, Younsoo Kim, Ji Seon Kim, Kyum-Yil Kwon, Jeong-Ho Park, Jinyoung Youn, Wooyoung Jang; J Mov Disord. 2018;11(1):24-29. Published online January 23, 2018; DOI: https://doi.org/10.14802/jmd.17058

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Abstract PDF Supplementary Material

Objective
Postural instability and gait disturbance are the cardinal symptoms associated with falling among patients with Parkinson’s disease (PD). The Tinetti mobility test (TMT) is a well-established measurement tool used to predict falls among elderly people. However, the TMT has not been established or widely used among PD patients in Korea. The purpose of this study was to evaluate the reliability and validity of the Korean version of the TMT for PD patients.
Methods
Twenty-four patients diagnosed with PD were enrolled in this study. For the interrater reliability test, thirteen clinicians scored the TMT after watching a video clip. We also used the test-retest method to determine intrarater reliability. For concurrent validation, the unified Parkinson’s disease rating scale, Hoehn and Yahr staging, Berg Balance Scale, Timed-Up and Go test, 10-m walk test, and gait analysis by three-dimensional motion capture were also used. We analyzed receiver operating characteristic curve to predict falling.
Results
The interrater reliability and intrarater reliability of the Korean Tinetti balance scale were 0.97 and 0.98, respectively. The interrater reliability and intra-rater reliability of the Korean Tinetti gait scale were 0.94 and 0.96, respectively. The Korean TMT scores were significantly correlated with the other clinical scales and three-dimensional motion capture. The cutoff values for predicting falling were 14 points (balance subscale) and 10 points (gait subscale).
Conclusion
We found that the Korean version of the TMT showed excellent validity and reliability for gait and balance and had high sensitivity and specificity for predicting falls among patients with PD.

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Validity and Reliability of the Korean-Translated Version of the International Cooperative Ataxia Rating Scale in Cerebellar Ataxia
Jinse Park, Jin Whan Cho, Jinyoung Youn, Engseok Oh, Wooyoung Jang, Joong-Seok Kim, Yoon-Sang Oh, Hyungyoung Hwang, Chang-Hwan Rhu, Jin-Young Ahn, Jee-Young Lee, Seong-Beom Koh, Jae H. Park, Hee-Tae Kim
Journal of Movement Disorders.2023; 16(1): 86. CrossRef
Dance Intervention Using the Feldenkrais Method Improves Motor, and Non-Motor Symptoms and Gait in Parkinson’s Disease: A 12-Month Study
Sung Hoon Kang, Jinhee Kim, Ilsoo Kim, Young Ae Moon, Sojung Park, Seong-Beom Koh
Journal of Movement Disorders.2022; 15(1): 53. CrossRef
Evaluation of Anticipatory Postural Adjustment before Quantified Weight Shifting—System Development and Reliability Test
Jiunn-Woei Liaw, Rou-Shayn Chen, Vincent Chiun-Fan Chen, Yan-Ru Wang, Hsiao-Lung Chan, Ya-Ju Chang
Applied Sciences.2021; 11(2): 758. CrossRef
Use of Standardized and Non-Standardized Tools for Measuring the Risk of Falls and Independence in Clinical Practice
Jan Neugebauer, Valérie Tóthová, Jitka Doležalová
International Journal of Environmental Research and Public Health.2021; 18(6): 3226. CrossRef
Decreased foot height may be a subclinical shuffling gait in early stage of Parkinson’s disease: A study of three-dimensional motion analysis
Kyong Jin Shin, Jinse Park, Samyeol Ha, Kang Min Park, Sung Eun Kim, Byung In Lee, Dong Ah Lee, Hee-Tae Kim, Ji-Yeon Yoon
Gait & Posture.2020; 76: 64. CrossRef
Design of a Machine Learning-Assisted Wearable Accelerometer-Based Automated System for Studying the Effect of Dopaminergic Medicine on Gait Characteristics of Parkinson’s Patients
Satyabrata Aich, Pyari Mohan Pradhan, Sabyasachi Chakraborty, Hee-Cheol Kim, Hee-Tae Kim, Hae-Gu Lee, Il Hwan Kim, Moon-il Joo, Sim Jong Seong, Jinse Park
Journal of Healthcare Engineering.2020; 2020: 1. CrossRef
Psychometric properties and domains of postural control tests for individuals with knee osteoarthritis: a systematic review
Helen P. French, Charlotte K. Hager, Anne Venience, Ryan Fagan, Dara Meldrum
International Journal of Rehabilitation Research.2020; 43(2): 102. CrossRef
Measures of balance and falls risk prediction in people with Parkinson’s disease: a systematic review of psychometric properties
Stanley J Winser, Priya Kannan, Umar Muhhamad Bello, Susan L Whitney
Clinical Rehabilitation.2019; 33(12): 1949. CrossRef
Allelic variant in SLC6A3 rs393795 affects cerebral regional homogeneity and gait dysfunction in patients with Parkinson’s disease
Lina Wang, Yongsheng Yuan, Jianwei Wang, Yuting Shen, Yan Zhi, Junyi Li, Min Wang, Kezhong Zhang
PeerJ.2019; 7: e7957. CrossRef
Evaluation of Balance Disorders in Parkinson's Disease Using Simple Diagnostic Tests—Not So Simple to Choose
Karolina Krzysztoń, Jakub Stolarski, Jan Kochanowski
Frontiers in Neurology.2018;[Epub] CrossRef
Rasch Analysis of the Clinimetric Properties of the Korean Dizziness Handicap Inventory in Patients with Parkinson Disease
Da-Young Lee, Hui-Jun Yang, Dong-Seok Yang, Jin-Hyuk Choi, Byoung-Soo Park, Ji-Yun Park
Research in Vestibular Science.2018; 17(4): 152. CrossRef

Quantitative Gait Analysis in Patients with Huntington’s Disease: Seon Jong Pyo, Hanjun Kim, Il Soo Kim, Young-Min Park, Mi-Jung Kim, Hye Mi Lee, Seong-Beom Koh; J Mov Disord. 2017;10(3):140-144. Published online August 31, 2017; DOI: https://doi.org/10.14802/jmd.17041

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Abstract PDF

Objective
Gait disturbance is the main factor contributing to a negative impact on quality of life in patients with Huntington’s disease (HD). Understanding gait features in patients with HD is essential for planning a successful gait strategy. The aim of this study was to investigate temporospatial gait parameters in patients with HD compared with healthy controls.
Methods
We investigated 7 patients with HD. Diagnosis was confirmed by genetic analysis, and patients were evaluated with the Unified Huntington’s Disease Rating Scale (UHDRS). Gait features were assessed with a gait analyzer. We compared the results of patients with HD to those of 7 age- and sex-matched normal controls.
Results
Step length and stride length were decreased and base of support was increased in the HD group compared to the control group. In addition, coefficients of variability for step and stride length were increased in the HD group. The HD group showed slower walking velocity, an increased stance/swing phase in the gait cycle and a decreased proportion of single support time compared to the control group. Cadence did not differ significantly between groups. Among the UHDRS subscores, total motor score and total behavior score were positively correlated with step length, and total behavior score was positively correlated with walking velocity in patients with HD.
Conclusion
Increased variability in step and stride length, slower walking velocity, increased stance phase, and decreased swing phase and single support time with preserved cadence suggest that HD gait patterns are slow, ataxic and ineffective. This study suggests that quantitative gait analysis is needed to assess gait problems in HD.

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Human Gait Analysis in Neurodegenerative Diseases: A Review
Grazia Cicirelli, Donato Impedovo, Vincenzo Dentamaro, Roberto Marani, Giuseppe Pirlo, Tiziana R. D'Orazio
IEEE Journal of Biomedical and Health Informatics.2022; 26(1): 229. CrossRef
Development of Neuro-Degenerative Diseases’ Gait Classification Algorithm Using Convolutional Neural Network and Wavelet Coherence Spectrogram of Gait Synchronization
Febryan Setiawan, An-Bang Liu, Che-Wei Lin
IEEE Access.2022; 10: 38137. CrossRef
Artificial intelligence in neurodegenerative diseases: A review of available tools with a focus on machine learning techniques
Alexandra-Maria Tăuţan, Bogdan Ionescu, Emiliano Santarnecchi
Artificial Intelligence in Medicine.2021; 117: 102081. CrossRef
Identification of Neurodegenerative Diseases Based on Vertical Ground Reaction Force Classification Using Time–Frequency Spectrogram and Deep Learning Neural Network Features
Febryan Setiawan, Che-Wei Lin
Brain Sciences.2021; 11(7): 902. CrossRef
The effects of dual-task cognitive interference on gait and turning in Huntington’s disease
Nicollette L. Purcell, Jennifer G. Goldman, Bichun Ouyang, Yuanqing Liu, Bryan Bernard, Joan A. O’Keefe, Pedro Gonzalez-Alegre
PLOS ONE.2020; 15(1): e0226827. CrossRef
Gait variability as digital biomarker of disease severity in Huntington’s disease
Heiko Gaßner, Dennis Jensen, F. Marxreiter, Anja Kletsch, Stefan Bohlen, Robin Schubert, Lisa M. Muratori, Bjoern Eskofier, Jochen Klucken, Jürgen Winkler, Ralf Reilmann, Zacharias Kohl
Journal of Neurology.2020; 267(6): 1594. CrossRef
Evaluation of Vertical Ground Reaction Forces Pattern Visualization in Neurodegenerative Diseases Identification Using Deep Learning and Recurrence Plot Image Feature Extraction
Che-Wei Lin, Tzu-Chien Wen, Febryan Setiawan
Sensors.2020; 20(14): 3857. CrossRef
Cerebral dopamine neurotrophic factor (CDNF) protects against quinolinic acid-induced toxicity in in vitro and in vivo models of Huntington’s disease
P. Stepanova, V. Srinivasan, D. Lindholm, M. H. Voutilainen
Scientific Reports.2020;[Epub] CrossRef
Rapid and robust patterns of spontaneous locomotor deficits in mouse models of Huntington’s disease
Taneli Heikkinen, Timo Bragge, Niina Bhattarai, Teija Parkkari, Jukka Puoliväli, Outi Kontkanen, Patrick Sweeney, Larry C. Park, Ignacio Munoz-Sanjuan, Yuqing Li
PLOS ONE.2020; 15(12): e0243052. CrossRef
Rule based classification of neurodegenerative diseases using data driven gait features
Kartikay Gupta, Aayushi Khajuria, Niladri Chatterjee, Pradeep Joshi, Deepak Joshi
Health and Technology.2019; 9(4): 547. CrossRef
Discovery of Arginine Ethyl Ester as Polyglutamine Aggregation Inhibitor: Conformational Transitioning of Huntingtin N-Terminus Augments Aggregation Suppression
Virender Singh, Kinjal A. Patel, Raj Kumar Sharma, Pratik R. Patil, Abhayraj S. Joshi, Rashmi Parihar, Thamarailingam Athilingam, Neeraj Sinha, Subramaniam Ganesh, Pradip Sinha, Ipsita Roy, Ashwani Kumar Thakur
ACS Chemical Neuroscience.2019; 10(9): 3969. CrossRef
Gait Biomarkers Classification by Combining Assembled Algorithms and Deep Learning: Results of a Local Study
Eddy Sánchez-DelaCruz, Roberto Weber, R. R. Biswal, Jose Mejía, Gandhi Hernández-Chan, Heberto Gómez-Pozos
Computational and Mathematical Methods in Medicine.2019; 2019: 1. CrossRef

Patients and Their Caregivers’ Burdens for Parkinson’s Disease in Korea: Jong Sam Baik, Joong-Seok Kim, Seong-Beom Koh, Jin Whan Cho, Phil Hyu Lee, Hyeo-Il Ma, Yun Joong Kim, Tae-Beom Ahn, Sang Jin Kim, Yong Duk Kim, Seong-min Choi, Ho-Won Lee, Hee Tae Kim; J Mov Disord. 2017;10(3):109-115. Published online September 22, 2017; DOI: https://doi.org/10.14802/jmd.17053

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Abstract PDF

Objective
Many patients with Parkinson’s disease (PD) suffer from motor and non-motor symptoms. According to these variable symptoms of PD, patients or caregivers have a poorer quality of life than patients with other neurodegenerative diseases. Since the difficulties are varied for all patients, prioritizing their difficulties differs among all cases. The goal of this study was to investigate the burdens of PD among the caregivers as well as patients and to identify areas requiring aid from the government.
Methods
We surveyed the awareness and perceptions of PD in patients and caregivers of PD by a face-to-face questionnaire. The questionnaire was divided into three sections: symptoms of PD (part A), desire for policies (part B), and difficulties faced by their caregivers (part C). Part A comprised 8 questions, Part B had 2 questions, and Part C had 3 questions.
Results
In total, 853 subjects (702 patients and 151 caregivers) were enrolled in this study. The major difficulties experienced by PD patients were physical (67%), psychiatric (60%) and socio-economic (52%). Assessing the physical difficulties, more than half the patients experienced severe difficulties (29% very severe, 39% severe). Psychiatric difficulties were assessed as severe (35%) and very severe (21%) among the patients. Severe difficulties were also experienced socio-economically, at 52% in patients and 49% in caregivers, especially among patients in their fifties (58%) and those with their spouse (65%) as caregivers. The topmost need was the introduction of new technology for treatment of PD (62%), followed by relief of costs for treatment (38%) and a family support system (31%). The majority (91%) of the patients were diagnosed with PD within two years after onset of symptoms.
Conclusion
We know that the difficulties of PD and the needs for government assistance are different between patients and caregivers. These results emphasize that perceiving the difficulties and needs of patients and caregivers early can help to prevent and ameliorate the burden of disease.

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Challenges in Parkinson’s Disease Care—In Light of the COVID-19 Pandemic
Kyung Ah Woo, Han-Joon Kim, Beomseok Jeon
Journal of Movement Disorders.2023; 16(1): 52. CrossRef
Exploring Unmet Information Needs of People with Parkinson’s Disease and Their Families: Focusing on Information Sharing in an Online Patient Community
Hyeon Sik Chu, Hye Young Jang
International Journal of Environmental Research and Public Health.2022; 19(5): 2521. CrossRef
Participants' perspective on a COVID-19 online vocal group stimulation for people with Parkinson's disease
Marie-Christine Hallé, Charline Delorme, Édith Coulombe, Ouswa Rekik, Ingrid Verduyckt
Frontiers in Rehabilitation Sciences.2022;[Epub] CrossRef
Group singing improves quality of life for people with Parkinson’s: an international study
J. Yoon Irons, Grenville Hancox, Trish Vella-Burrows, Eun-Young Han, Hyun-Ju Chong, David Sheffield, Donald E. Stewart
Aging & Mental Health.2021; 25(4): 650. CrossRef
Exploring the perceptions and stigmatizing experiences of Israeli family caregivers of people with Parkinson's disease
Hanan AboJabel, Einat Argavan, Sharon Hassin-Baer, Rivka Inzelberg, Perla Werner
Journal of Aging Studies.2021; 56: 100910. CrossRef
Perceived online social support for Parkinson’s disease patients: The role of support type, uncertainty, contentment, and psychological quality of life
Surin Chung, Eunjin (Anna) Kim, J. Brian Houston
Communication Quarterly.2021; 69(3): 259. CrossRef
Delivering patient-centered care in Parkinson's disease: Challenges and consensus from an international panel
Roongroj Bhidayasiri, Pattamon Panyakaew, Claudia Trenkwalder, Beomseok Jeon, Nobutaka Hattori, Priya Jagota, Yih-Ru Wu, Elena Moro, Shen-Yang Lim, Huifang Shang, Raymond Rosales, Jee-Young Lee, Win Min Thit, Eng-King Tan, Thien Thien Lim, Ngoc Tai Tran,
Parkinsonism & Related Disorders.2020; 72: 82. CrossRef
Understanding patients’ and caregivers’ perspectives and educational needs in Parkinson’s disease: a multi-ethnic Asian study
Xing Yan Choo, Shen-Yang Lim, Karuthan Chinna, Yan Jing Tan, Voon Wei Yong, Jia Lun Lim, Kar Foo Lau, Jing Yi Chung, Jun Min Em, Hui Ting Tan, Jia Hwa Lim, Seng Beng Tan, Chong Tin Tan, Ai Huey Tan
Neurological Sciences.2020; 41(10): 2831. CrossRef
Nörolojik Hastalık ve Evlilik
Mehmet ÖNGER, Tuba AYDIN
Sakarya Medical Journal.2020;[Epub] CrossRef
The burden of care and the understanding of disease in Parkinson’s disease
Geum-Bong Lee, Hyunhee Woo, Su-Yoon Lee, Sang-Myung Cheon, Jae Woo Kim, Oscar Arias-Carrion
PLOS ONE.2019; 14(5): e0217581. CrossRef

Sleepiness and Depression in Parkinson’s Disease Patients Treated with Ropinirole and Levodopa: Suk Yun Kang, Ho-Sung Ryu, Mun-Kyung Sunwoo, Sang-Jin Kim, Jong-Sam Baik, Mee-Young Park, Hyung-Eun Park, Joong-Seok Kim, Kyum-Yil Kwon, Seong-Beom Koh, Young-Eun Kim, Mi-Kyong Lee, Jong-Min Kim, Sun Ju Chung, Young-Ho Sohn; J Mov Disord. 2017;10(3):123-129. Published online September 22, 2017; DOI: https://doi.org/10.14802/jmd.17048

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Abstract PDF

Objective
We aimed to investigate the effect of ropinirole on excessive daytime sleepiness (EDS) and depression in Parkinson’s disease (PD) with a large population.
Methods
We conducted a cross-sectional observational study at nine hospitals in Korea between April 24, 2013, and April 22, 2015. We analyzed the demographic and clinical features, other medical history, history of antiparkinsonian medication within 6 months, Hoehn and Yahr stage (HY stage), Unified Parkinson’s Disease Rating Scale (UPDRS) part II and III, Epworth Sleepiness Scale (ESS), and 30-item Geriatric Depression Scale (GDS-30).
Results
Four-hundred-thirteen patients with PD (mean age: 65.2 ± 9.0 years; men: 227 patients) were analyzed. Multivariate logistic regression analysis showed that age at examination, UPDRS II, and GDS-30 were independent risk factors for EDS and that sex, UPDRS II, and ESS were independent risk factors for depression.
Conclusion
Our large group study did not find any significant associations of ropinirole with EDS and depression in Korean PD patients.

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Excessive Daytime Sleepiness in Parkinson’s Disease
Hanshu Liu, Jingwen Li, Xinyi Wang, Jinsha Huang, Tao Wang, Zhicheng Lin, Nian Xiong
Nature and Science of Sleep.2022; Volume 14: 1589. CrossRef
Excessive daytime sleepiness in Parkinson's disease: A systematic review and meta-analysis
Fei Feng, YingYing Cai, YanBing Hou, Ruwei Ou, Zheng Jiang, HuiFang Shang
Parkinsonism & Related Disorders.2021; 85: 133. CrossRef
Sleep Disorders and Cognitive Dysfunctions in Parkinson’s Disease: A Meta-Analytic Study
Gianpaolo Maggi, Luigi Trojano, Paolo Barone, Gabriella Santangelo
Neuropsychology Review.2021; 31(4): 643. CrossRef
Longitudinal risk factors for developing depressive symptoms in Parkinson's disease
Tarek Antar, Huw R. Morris, Faraz Faghri, Hampton L. Leonard, Mike A. Nalls, Andrew B. Singleton, Hirotaka Iwaki
Journal of the Neurological Sciences.2021; 429: 117615. CrossRef
The effect and safety of ropinirole in the treatment of Parkinson disease
Jiali Zhu, Min Chen
Medicine.2021; 100(46): e27653. CrossRef
Pramipexole regulates depression-like behavior via dopamine D3 receptor in a mouse model of Parkinson’s disease
Shi-Zhuang Wei, Xiao-Yu Yao, Chen-Tao Wang, An-Qi Dong, Dan Li, Yu-Ting Zhang, Chao Ren, Jin-Bao Zhang, Cheng-Jie Mao, Fen Wang, Chun-Feng Liu
Brain Research Bulletin.2021; 177: 363. CrossRef
A selective D2 dopamine receptor agonist alleviates depression through up-regulation of tyrosine hydroxylase and increased neurogenesis in hippocampus of the prenatally stressed rats
Mahino Fatima, Mir Hilal Ahmad, Saurabh Srivastav, Moshahid Alam Rizvi, A.C. Mondal
Neurochemistry International.2020; 136: 104730. CrossRef
‘Dopamine agonist Phobia’ in Parkinson’s disease: when does it matter? Implications for non-motor symptoms and personalized medicine
Silvia Rota, Iro Boura, Lucia Batzu, Nataliya Titova, Peter Jenner, Cristian Falup-Pecurariu, K Ray Chaudhuri
Expert Review of Neurotherapeutics.2020; 20(9): 953. CrossRef
An Investigation on the Clinical Features and Neurochemical Changes in Parkinson's Disease With Depression
Teng-Hong Lian, Peng Guo, Li-Jun Zuo, Yang Hu, Shu-Yang Yu, Li Liu, Zhao Jin, Qiu-Jin Yu, Rui-Dan Wang, Li-Xia Li, Ying-Shan Piao, Wei Zhang
Frontiers in Psychiatry.2019;[Epub] CrossRef

Validation of the Korean Version of the Scale for Outcomes in Parkinson’s Disease-Autonomic: Ji-Young Kim, In-Uk Song, Seong-Beom Koh, Tae-Beom Ahn, Sang Jin Kim, Sang-Myung Cheon, Jin Whan Cho, Yun Joong Kim, Hyeo-Il Ma, Mee-Young Park, Jong Sam Baik, Phil Hyu Lee, Sun Ju Chung, Jong-Min Kim, Han-Joon Kim, Young-Hee Sung, Do Young Kwon, Jae-Hyeok Lee, Jee-Young Lee, Ji Sun Kim, Ji Young Yun, Hee Jin Kim, Jin Young Hong, Mi-Jung Kim, Jinyoung Youn, Ji Seon Kim, Eung Seok Oh, Hui-Jun Yang, Won Tae Yoon, Sooyeoun You, Kyum-Yil Kwon, Hyung-Eun Park, Su-Yun Lee, Younsoo Kim, Hee-Tae Kim, Joong-Seok Kim; J Mov Disord. 2017;10(1):29-34. Published online January 18, 2017; DOI: https://doi.org/10.14802/jmd.16057

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Abstract PDF Supplementary Material

Objective
Autonomic symptoms are commonly observed in patients with Parkinson’s disease (PD) and often limit the activities of daily living. The Scale for Outcomes in Parkinson’s disease-Autonomic (SCOPA-AUT) was developed to evaluate and quantify autonomic symptoms in PD. The goal of this study was to translate the original SCOPA-AUT, which was written in English, into Korean and to evaluate its reliability and validity for Korean PD patients.
Methods
For the translation, the following processes were performed: forward translation, backward translation, expert review, pretest of the pre-final version and development of the final Korean version of SCOPA-AUT (K-SCOPA-AUT). In total, 127 patients with PD from 31 movement disorder clinics of university-affiliated hospitals in Korea were enrolled in this study. All patients were assessed using the K-SCOPA-AUT and other motor, non-motor, and quality of life scores. Test-retest reliability for the K-SCOPA-AUT was assessed over a time interval of 10−14 days.
Results
The internal consistency and reliability of the K-SCOPA-AUT was 0.727 as measured by the mean Cronbach’s α-coefficient. The test-retest correlation reliability was 0.859 by the Guttman split-half coefficient. The total K-SCOPA-AUT score showed a positive correlation with other non-motor symptoms [the Korean version of non-motor symptom scale (K-NMSS)], activities of daily living (Unified Parkinson’s Disease Rating Scale part II) and quality of life [the Korean version of Parkinson’s Disease Quality of Life 39 (K-PDQ39)].
Conclusion
The K-SCOPA-AUT had good reliability and validity for the assessment of autonomic dysfunction in Korean PD patients. Autonomic symptom severities were associated with many other motor and non-motor impairments and influenced quality of life.

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Cognition and Visit-to-Visit Variability of Blood Pressure and Heart Rate in De Novo Patients with Parkinson’s Disease: Kyum-Yil Kwon, Seon Jong Pyo, Hye Mi Lee, Woo-Keun Seo, Seong-Beom Koh; J Mov Disord. 2016;9(3):144-151. Published online September 21, 2016; DOI: https://doi.org/10.14802/jmd.16012

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Abstract PDF Supplementary Material

Objective
We sought to identify whether the characteristics of long-term visit-to-visit blood pressure (BP) and heart rate (HR) are related to baseline cognitive profiles in, Parkinson’s disease (PD).
Methods
We selected drug-naïve PD patients who visited our hospital at least 10 times with a baseline assessment of the Seoul neuropsychological battery. BP and HR were measured at each visit, and the variability of the systolic BP/diastolic BP (DBP) and HR was derived from the parameters of serial 10 office visits. Mild cognitive impairment (MCI) in PD patients was determined according to the proposed criteria with a cut-off value of z-score ≤ -2.
Results
Forty-seven patients with PD (mean follow-up duration = 22.3 months) were enrolled in the study. Compared with non-MCI PD patients, MCI PD patients revealed a significant increase in HR and/or variability in DBP.
Conclusion
This exploratory study showed that baseline cognition in drug-naïve PD patients might be related to the visit-to-visit variability of DBP and/or HR.

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Many Faces of Parkinson’s Disease: Non-Motor Symptoms of Parkinson’s Disease: Hye Mi Lee, Seong-Beom Koh; J Mov Disord. 2015;8(2):92-97. Published online May 31, 2015; DOI: https://doi.org/10.14802/jmd.15003

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Abstract PDF

Parkinson’s disease (PD) is a multi-systemic disorder that is characterized by a combination of motor and non-motor symptoms (NMS). The dopaminergic neurodegeneration of PD is involved in the genesis of NMS, but other conditions and side effects of levodopa are also associated with NMS. NMS can develop at all stage of PD and rapid eyeball movement sleep behavior disorder (RBD), constipation, depression, and olfactory dysfunction are considered prodromal signs of PD. Many NMS related with motor deficits and cognitive dysfunction. Some NMS including olfactory dysfunction, RBD and abnormal stereopsis are associated with presence of other NMS of PD. In addition, several NMS can be helpful to differentiate between idiopathic PD and other parkinsonian disorders. Early recognition and management of NMS in PD patients is important for preserving quality of life.

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Clinical Features and Disability Milestones in Multiple System Atrophy and Progressive Supranuclear Palsy: Sang-Wook Lee, Seong-Beom Koh; J Mov Disord. 2012;5(2):42-47.; DOI: https://doi.org/10.14802/jmd.12010

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Abstract PDF

Multiple system atrophy (MSA) and progressive supranuclear palsy (PSP) are an adult-onset progressive neurodegenerative disorder that are known to display diverse clinical features and disease progression. We aim to characterize the clinical features and disease progression in patients with MSA and PSP by using a number of relevant disability milestones in Koreans. Forty-one patients with MSA and 14 patients with PSP had been enrolled. The mean age at onset of MSA-C, MSA-P and PSP was 56.7 ± 7.8, 62.5 ± 8.0, 68.9 ± 6.1 years respectively. The most commonly reported symptom at disease onset is disequilibrium/dizziness in MSA-C, tremor in MSA-P and frequent falling in PSP. The mean duration of reaching milestones after disease onset in MSA-C were as followings: 20.8 (urinary incontinence), 22.9 (frequent falling), 27.8 (wheelchair bound), 31.8 (dysarthria) and 35.8 months (diagnosis). The mean duration of reaching milestones after disease onset were 22.0 (urinary incontinence), 32.6 (frequent falling and diagnosis), 41.2 (dysarthria), 61.4 months (wheelchair bound) in MSA-P and 16.8 (dysarthria), 21.6 (diagnosis), 21.7 (frequent falling), 24.0 months (wheel chair bound) in PSP. In the case of MSA, dizziness may occur for the first time. Thus, when the patient complains of non-specific dizziness, a follow-up examination to distinguish it from MSA can be helpful. There was a trend for patients with MSA-C to reach more disability milestones than in MSA-P and PSP before diagnosis. It may explain why patients with MSA-C are required more detail history taking and neurologic examination at an earlier stage.

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Disease course and treatment patterns in progressive supranuclear palsy: A real-world study
John C. Morgan, Xiaolan Ye, Jennifer A. Mellor, Keisha J. Golden, Jorge Zamudio, Louis A. Chiodo, Yanjun Bao, Tao Xie
Journal of the Neurological Sciences.2021; 421: 117293. CrossRef
Progression of Oropharyngeal Dysphagia in Patients with Multiple System Atrophy
Hui Jae Do, Han Gil Seo, Hyun Haeng Lee, Byung-Mo Oh, Yoon Kim, Aryun Kim, Han-Joon Kim, Beomseok Jeon, Tai Ryoon Han
Dysphagia.2020; 35(1): 24. CrossRef
Is There a Difference in Autonomic Dysfunction Between Multiple System Atrophy Subtypes?
Divyani Garg, Achal Kumar Srivastava, Ashok Kumar Jaryal, Roopa Rajan, Akanksha Singh, Awadh Kishor Pandit, Deepti Vibha, Garima Shukla, Ajay Garg, Ravindra Mohan Pandey, Kameshwar Prasad
Movement Disorders Clinical Practice.2020; 7(4): 405. CrossRef
Models of multiple system atrophy
He-Jin Lee, Diadem Ricarte, Darlene Ortiz, Seung-Jae Lee
Experimental & Molecular Medicine.2019; 51(11): 1. CrossRef
Multiple System Atrophy: An Oligodendroglioneural Synucleinopathy1
Kurt A. Jellinger, George Perry, Jesus Avila, Massimo Tabaton, Xiongwei Zhu
Journal of Alzheimer's Disease.2018; 62(3): 1141. CrossRef
Present and future of disease-modifying therapies in multiple system atrophy
Miguel Lopez-Cuina, Alexandra Foubert-Samier, François Tison, Wassilios G. Meissner
Autonomic Neuroscience.2018; 211: 31. CrossRef
Different subregional metabolism patterns in patients with cerebellar ataxia by 18F-fluorodeoxyglucose positron emission tomography
Minyoung Oh, Jae Seung Kim, Jungsu S. Oh, Chong Sik Lee, Sun Ju Chung, Byeong-Cheol Ahn
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Thomas Cronin, Qadeer Arshad, Barry M. Seemungal
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Progressive supranuclear palsy: progression and survival
Julieta E. Arena, Stephen D. Weigand, Jennifer L. Whitwell, Anhar Hassan, Scott D. Eggers, Günter U. Höglinger, Irene Litvan, Keith A. Josephs
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Multiple system atrophy: pathogenic mechanisms and biomarkers
Kurt A. Jellinger, Gregor K. Wenning
Journal of Neural Transmission.2016; 123(6): 555. CrossRef
Urinary Dysfunction in Progressive Supranuclear Palsy Compared with Other Parkinsonian Disorders
Tatsuya Yamamoto, Fuyuki Tateno, Ryuji Sakakibara, Shogo Furukawa, Masato Asahina, Tomoyuki Uchiyama, Shigeki Hirano, Yoshitaka Yamanaka, Miki Fuse, Yasuko Koga, Mitsuru Yanagisawa, Satoshi Kuwabara, Jong-Ling Fuh
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Hemichorea-Hemiballism with a Diabetic Patient: Yoo Hwan Kim, Ju Yeon Kim, Hung Youl Seok, Seong-Beom Koh; J Mov Disord. 2010;3(1):20-21.; DOI: https://doi.org/10.14802/jmd.10006

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Abstract PDF

Chorea and ballism are movement disorders that result from a variety of conditions. They are an uncommon manifestation of diabetes mellitus. We report a 52-year-old diabetic man who presented with acute onset chorea-ballism with a putaminal high-signal-intensity lesion on T1-weighted magnetic resonance imaging (MRI).

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“Diabetic striatopathy”: clinical presentations, controversy, pathogenesis, treatments, and outcomes
Choon-Bing Chua, Cheuk-Kwan Sun, Chih-Wei Hsu, Yi-Cheng Tai, Chih-Yu Liang, I-Ting Tsai
Scientific Reports.2020;[Epub] CrossRef
NEUROLOGINĖ PATOLOGIJA SERGANT 2 TIPO CUKRINIU DIABETU
Liudmila Kimševaitė
Medicinos teorija ir praktika.2017; 22(4): 328. CrossRef

Generalized Chorea Induced by an Unilateral Anterior Cerebral Artery Territorial Infarction: Jae Hong Chang, Woo-Keun Seo, Moon-Ho Park, Jong-Mun Lee, Do-Young Kwon, Seong-Beom Koh; J Mov Disord. 2009;2(1):37-39.; DOI: https://doi.org/10.14802/jmd.09009

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Abstract PDF

Generalized chorea caused by unilateral cerebral infarction has rarely been reported. A 58-year-old woman presented involuntary movement in her all extremities after acute cerebral infarction on her right anterior cerebral artery territory. The involuntary movements were diagnosed as generalized chorea. We didn’t find any cause of generalized chorea except the acute cerebral infarction. Here, we described the case of generalized chorea after unilateral cerebral infarction discussing the possible mechanisms.

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Movement Disorders Associated With Cerebral Artery Stenosis: A Nationwide Study
Kye Won Park, Nari Choi, Eungseok Oh, Chul Hyoung Lyoo, Min Seok Baek, Han-Joon Kim, Dalla Yoo, Jee-Young Lee, Ji-Hyun Choi, Jae Hyeok Lee, Seong-Beom Koh, Young Hee Sung, Jin Whan Cho, Hui-Jun Yang, Jinse Park, Hae-Won Shin, Tae-Beom Ahn, Ho-Sung Ryu, So
Frontiers in Neurology.2022;[Epub] CrossRef
Acute Hemichorea as an Unusual Presentation of Internal Carotid Artery Stenosis
Dong Wook Kim, Youngchai Ko, Sang Hyun Jang, Soo Jin Yoon, Gun-Sei Oh, Soo Joo Lee, Dong Joo Yun
Journal of Movement Disorders.2013; 6(1): 17. CrossRef

Gait Analysis in Patients With Parkinson’s Disease: Relationship to Clinical Features and Freezing: Seong-Beom Koh, Kun-Woo Park, Dae-Hie Lee, Se Ju Kim, Joon-Shik Yoon; J Mov Disord. 2008;1(2):59-64.; DOI: https://doi.org/10.14802/jmd.08011

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Abstract PDF

Background:

The purpose of our study was to investigate gait dynamics and kinematics in patients with Parkinson’s disease (PD) and to correlate these features with the predominant clinical features and with the presence of the freezing of gait (FOG). We measured the temporospatial and kinematic parameters of gait in 30 patients with PD (M:F=12:18, age=68.43±7.54) using a computerized video motion analysis system.

Methods:

We divided the subjects into subgroups: (1) tremor-dominant (TD) group and postural instability and gait disturbance (PIGD) group and (2) FOG group and non-FOG group. We compared the gait parameters between the subgroups.

Results:

The walking velocity and stride length were reduced significantly in the PIGD group compared to the TD group. The PIGD group showed a significantly reduced range of motion in the pelvic and lower extremity joints by kinematics. Stride time variability was significantly increased and the pelvic oblique range was significantly reduced in the freezing gait disorder group.

Conclusion:

Our findings suggest that there are differences in the perturbation of the basal ganglia-cortical circuits based on major clinical features. The reduction of the pelvic oblique range of motion may be a compensatory mechanism for postural instability and contributes to stride time variability in patients with FOG.

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Proof of Concept in Artificial-Intelligence-Based Wearable Gait Monitoring for Parkinson’s Disease Management Optimization
Robert Radu Ileșan, Claudia-Georgiana Cordoș, Laura-Ioana Mihăilă, Radu Fleșar, Ana-Sorina Popescu, Lăcrămioara Perju-Dumbravă, Paul Faragó
Biosensors.2022; 12(4): 189. CrossRef
Towards Real-Time Prediction of Freezing of Gait in Patients With Parkinson’s Disease: A Novel Deep One-Class Classifier
Nader Naghavi, Eric Wade
IEEE Journal of Biomedical and Health Informatics.2022; 26(4): 1726. CrossRef
Development of Neuro-Degenerative Diseases’ Gait Classification Algorithm Using Convolutional Neural Network and Wavelet Coherence Spectrogram of Gait Synchronization
Febryan Setiawan, An-Bang Liu, Che-Wei Lin
IEEE Access.2022; 10: 38137. CrossRef
Functional gait assessment in early and advanced Parkinson’s disease
Hany Mohamed Eldeeb, Heba Samir Abdelraheem
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery.2021;[Epub] CrossRef
Statistical methods for analysis of Parkinson’s disease gait pattern and classification
Anup Nandy
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Prediction of Freezing of Gait in Parkinson’s Disease Using Statistical Inference and Lower–Limb Acceleration Data
Nader Naghavi, Eric Wade
IEEE Transactions on Neural Systems and Rehabilitation Engineering.2019; 27(5): 947. CrossRef
Towards Real-Time Prediction of Freezing of Gait in Patients With Parkinson’s Disease: Addressing the Class Imbalance Problem
Nader Naghavi, Aaron Miller, Eric Wade
Sensors.2019; 19(18): 3898. CrossRef
Computer-Vision Based Diagnosis of Parkinson’s Disease via Gait: A Survey
Navleen Kour, Sunanda, Sakshi Arora
IEEE Access.2019; 7: 156620. CrossRef
A comparison of soft computing models for Parkinson’s disease diagnosis using voice and gait features
Rekh Ram Janghel, Anupam Shukla, Chandra Prakash Rathore, Kshitiz Verma, Swati Rathore
Network Modeling Analysis in Health Informatics and Bioinformatics.2017;[Epub] CrossRef

Cruciform Pontine MRI Hyperintensities (“Hot Cross Bun” Sign) in Non-Multiple System Atrophy Patients: Seong-Beom Koh, Kun-Woo Park, Dae-Hie Lee; J Mov Disord. 2008;1(2):107-108.; DOI: https://doi.org/10.14802/jmd.08022

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The “Hot Cross Bun Sign” in Spinocerebellar Ataxia Types 2 and 7–Case Reports and Review of Literature
Ansuya Kasavelu Naidoo, Cait‐Lynn Deanne Wells, Yashvir Rugbeer, Neil Naidoo
Movement Disorders Clinical Practice.2022; 9(8): 1105. CrossRef

Microglial Imaging in Movement Disorders With PK11195 PET: Seong-Beom Koh; J Mov Disord. 2008;1(1):1-5.; DOI: https://doi.org/10.14802/jmd.08001

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Abstract PDF: Activated microglia play a major role in the pathogenesis in neurological disorders. The transition of microglia from the normal resting state to the activated state is associated with an increased expression of receptors known as peripheral benzodiazepine binding sites, which are abundant on cells of mononuclear phagocyte lineage. PK11195 is a ligand which binds selectively to peripheral benzodiazepine binding sites, a type of receptor selectively expressed by activated microglia in the central nervous system. The ¹¹C-(R)-PK11195 positron emission tomography (PET) is already applied to many kinds of neurological disorders, including neurodegenerative disorders, and can demonstrate the role of neuroinflammation in the pathogenesis of neurological disorders. And this imaging modality also provides a means to monitor potential clinical relevance of antiinflammatory treatment strategies in vivo. This article reviews some of the clinical applications of ¹¹C-(R)-PK11195 PET in the field of movement disorders.

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