- Exosome-Based Delivery of miR-124 in a Huntington’s Disease Model
-
Soon-Tae Lee, Wooseok Im, Jae-Jun Ban, Mijung Lee, Keun-Hwa Jung, Sang Kun Lee, Kon Chu, Manho Kim
-
J Mov Disord. 2017;10(1):45-52. Published online January 18, 2017
-
DOI: https://doi.org/10.14802/jmd.16054
-
-
17,675
View
-
378
Download
-
121
Web of Science
-
104
Crossref
-
Abstract
PDF
- Objective
Huntington’s disease (HD) is a genetic neurodegenerative disease that is caused by abnormal CAG expansion. Altered microRNA (miRNA) expression also causes abnormal gene regulation in this neurodegenerative disease. The delivery of abnormally downregulated miRNAs might restore normal gene regulation and have a therapeutic effect.
Methods
We developed an exosome-based delivery method to treat this neurodegenerative disease. miR-124, one of the key miRNAs that is repressed in HD, was stably overexpressed in a stable cell line. Exosomes were then harvested from these cells using an optimized protocol. The exosomes (Exo-124) exhibited a high level of miR-124 expression and were taken up by recipient cells.
Results
When Exo-124 was injected into the striatum of R6/2 transgenic HD mice, expression of the target gene, RE1-Silencing Transcription Factor, was reduced. However, Exo-124 treatment did not produce significant behavioral improvement.
Conclusion
This study serves as a proof of concept for exosome-based delivery of miRNA in neurodegenerative diseases.
-
Citations
Citations to this article as recorded by
- Progress of Exosomal MicroRNAs and Traditional Chinese Medicine Monomers in Neurodegenerative Diseases
Jinping Liang, Yuchen Zhu, Shasha Liu, Boyu Kuang, Zhifeng Tian, Ling Zhang, Songwei Yang, Meiyu Lin, Naihong Chen, Xuan Liu, Qidi Ai, Yantao Yang Phytotherapy Research.2024; 38(11): 5323. CrossRef - The role of exosomes in adult neurogenesis: implications for neurodegenerative diseases
Zhuoyang Yu, Yan Teng, Jing Yang, Lu Yang Neural Regeneration Research.2024; 19(2): 282. CrossRef - A vivid outline demonstrating the benefits of exosome-mediated drug delivery in CNS-associated disease environments
Rachayeeta Ray, Sougata Ghosh Chowdhury, Parimal Karmakar Archives of Biochemistry and Biophysics.2024; 753: 109906. CrossRef - Current progression in application of extracellular vesicles in central nervous system diseases
Xiang-Min Zhang, Jie Huang, Xiao-Ying Ni, Hui-Ru Zhu, Zhong-Xin Huang, Shuang Ding, Xin-Yi Yang, Yan-Di Tan, Jian-Fu Chen, Jin-Hua Cai European Journal of Medical Research.2024;[Epub] CrossRef - Therapeutic advances in neural regeneration for Huntington's disease
Francesco D'Egidio, Vanessa Castelli, Giorgia Lombardozzi, Fabrizio Ammannito, Annamaria Cimini, Michele d'Angelo Neural Regeneration Research.2024; 19(9): 1991. CrossRef - Extracellular vesicles in nanomedicine and regenerative medicine: A review over the last decade
Saeid Moghassemi, Arezoo Dadashzadeh, Maria João Sousa, Hanne Vlieghe, Jie Yang, Cecibel María León-Félix, Christiani A. Amorim Bioactive Materials.2024; 36: 126. CrossRef - Most recent advances and applications of extracellular vesicles in tackling neurological challenges
Mandeep Kaur, Salvatore Fusco, Bram Van den Broek, Jaya Aseervatham, Abdolmohamad Rostami, Lorraine Iacovitti, Claudio Grassi, Barbara Lukomska, Amit K. Srivastava Medicinal Research Reviews.2024; 44(4): 1923. CrossRef - Dual Role of Exosome in Neurodegenerative Diseases: A Review Study
Mohsen Sheykhhasan, Fatemeh Heidari, Mohsen Eslami Farsani, Maryam Azimzadeh, Naser Kalhor, Shima Ababzadeh, Reihaneh Seyedebrahimi Current Stem Cell Research & Therapy.2024; 19(6): 852. CrossRef -
Posttranscriptional regulation of
FAN1
by miR-124-3p at rs3512 underlies onset-delaying genetic modification in Huntington’s disease
Kyung-Hee Kim, Eun Pyo Hong, Yukyeong Lee, Zachariah L. McLean, Emanuela Elezi, Ramee Lee, Seung Kwak, Branduff McAllister, Thomas H. Massey, Sergey Lobanov, Peter Holmans, Michael Orth, Marc Ciosi, Darren G. Monckton, Jeffrey D. Long, Diane Lucente, Vane Proceedings of the National Academy of Sciences.2024;[Epub] CrossRef - Exosome-Based Macromolecular neurotherapeutic drug delivery approaches in overcoming the Blood-Brain barrier for treating brain disorders
Krishna Yadav, R. Vijayalakshmi, Kantrol Kumar Sahu, Pavani Sure, Kavita Chahal, Renu Yadav, Sucheta, Akhilesh Dubey, Megha Jha, Madhulika Pradhan European Journal of Pharmaceutics and Biopharmaceutics.2024; 199: 114298. CrossRef - MicroRNA biomarkers as next-generation diagnostic tools for neurodegenerative diseases: a comprehensive review
Hafiz Muhammad Husnain Azam, Rosa Ilse Rößling, Christiane Geithe, Muhammad Moman Khan, Franziska Dinter, Katja Hanack, Harald Prüß, Britta Husse, Dirk Roggenbuck, Peter Schierack, Stefan Rödiger Frontiers in Molecular Neuroscience.2024;[Epub] CrossRef - Extracellular Vesicles: The Next Generation of Biomarkers and Treatment for Central Nervous System Diseases
Gabriele Zanirati, Paula Gabrielli dos Santos, Allan Marinho Alcará, Fernanda Bruzzo, Isadora Machado Ghilardi, Vinicius Wietholter, Fernando Antônio Costa Xavier, João Ismael Budelon Gonçalves, Daniel Marinowic, Ashok K. Shetty, Jaderson Costa da Costa International Journal of Molecular Sciences.2024; 25(13): 7371. CrossRef - Exosome-derived microRNAs: emerging players in vitiligo
Wenquan li, Yaobin Pang, Qingying He, Zongzou Song, Xin Xie, Jinhao Zeng, Jing Guo Frontiers in Immunology.2024;[Epub] CrossRef - Mmu-let-7a-5p inhibits macrophage apoptosis by targeting CASP3 to increase bacterial load and facilities mycobacterium survival
Xuehua Zhan, Wenqi Yuan, Rong Ma, Yueyong Zhou, Guangxian Xu, Zhaohui Ge, Francesco Sessa PLOS ONE.2024; 19(9): e0308095. CrossRef - Extracellular vesicle and CRISPR gene therapy: Current applications in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and Huntington's disease
Enes Akyuz, Feyza Sule Aslan, Enise Gokce, Oguzkan Ilmaz, Feyzullah Topcu, Seda Kakac European Journal of Neuroscience.2024; 60(8): 6057. CrossRef - MicroRNAs regulation in Parkinson’s disease, and their potential role as diagnostic and therapeutic targets
Nour Shaheen, Ahmed Shaheen, Mahmoud Osama, Abdulqadir J. Nashwan, Vishal Bharmauria, Oliver Flouty npj Parkinson's Disease.2024;[Epub] CrossRef - Exosomes as nanocarrier for Neurotherapy: Journey from application to challenges
Yogita Ale, Nidhi Nainwal Journal of Drug Delivery Science and Technology.2024; 101: 106312. CrossRef - Exosome Cargo in Neurodegenerative Diseases: Leveraging Their Intercellular Communication Capabilities for Biomarker Discovery and Therapeutic Delivery
Shuai Zhang, Yu Yang, Xinchen Lv, Xue Zhou, Wangqian Zhao, Linfeng Meng, Shaohua Zhu, Zhixiang Zhang, Ying Wang Brain Sciences.2024; 14(11): 1049. CrossRef - Advances in gene and cellular therapeutic approaches for Huntington’s disease
Xuejiao Piao, Dan Li, Hui Liu, Qing Guo, Yang Yu Protein & Cell.2024;[Epub] CrossRef - Exosomal microRNAs as diagnostic biomarkers and therapeutic applications in neurodegenerative diseases
Xuehereti Sataer, Zhu Qifeng, Zhang Yingying, He Chunhua, Feng Bingzhenga, Xu Zhiran, Li Wanli, Yang Yuwei, Chen Shuangfeng, Wu Lingling, Huang Hongri, Chen Jibing, Ren Xiaoping, Gao Hongjun Neurological Research.2023; 45(3): 191. CrossRef - The role of microRNAs in neurodegenerative diseases: a review
Shijie Li, Zhixin Lei, Taolei Sun Cell Biology and Toxicology.2023; 39(1): 53. CrossRef - Exosomes based strategies for brain drug delivery
Fawad Ur Rehman, Yang Liu, Meng Zheng, Bingyang Shi Biomaterials.2023; 293: 121949. CrossRef - Contribution of Extracellular Vesicles and Molecular Chaperones in Age-Related Neurodegenerative Disorders of the CNS
Leila Noori, Kamila Filip, Zohreh Nazmara, Simin Mahakizadeh, Gholamreza Hassanzadeh, Celeste Caruso Bavisotto, Fabio Bucchieri, Antonella Marino Gammazza, Francesco Cappello, Maciej Wnuk, Federica Scalia International Journal of Molecular Sciences.2023; 24(2): 927. CrossRef - Nucleic acid drug vectors for diagnosis and treatment of brain diseases
Zhi-Guo Lu, Jie Shen, Jun Yang, Jing-Wen Wang, Rui-Chen Zhao, Tian-Lu Zhang, Jing Guo, Xin Zhang Signal Transduction and Targeted Therapy.2023;[Epub] CrossRef - Exosome-Based Carrier for RNA Delivery: Progress and Challenges
Yicheng Lu, Wei Huang, Meng Li, Aiping Zheng Pharmaceutics.2023; 15(2): 598. CrossRef - MicroRNA‑124: an emerging therapeutic target in central nervous system disorders
Wen-Hao Zhang, Lian Jiang, Mei Li, Jing Liu Experimental Brain Research.2023; 241(5): 1215. CrossRef - The role of exosomes in pathogenesis and the therapeutic efficacy of mesenchymal stem cell-derived exosomes against Parkinson’s disease
Maryam Abrishamdar, Maryam Sadat Jalali, Neda Yazdanfar Neurological Sciences.2023; 44(7): 2277. CrossRef - Small Extracellular Vesicles’ miRNAs: Biomarkers and Therapeutics for Neurodegenerative Diseases
Wei Qing Lim, Kie Hoon Michelle Luk, Kah Yee Lee, Nasuha Nurul, Sin Jade Loh, Zhen Xiong Yeow, Qi Xuan Wong, Qi Hao Daniel Looi, Pan Pan Chong, Chee Wun How, Sharina Hamzah, Jhi Biau Foo Pharmaceutics.2023; 15(4): 1216. CrossRef - Bioengineered Mesenchymal-Stromal-Cell-Derived Extracellular Vesicles as an Improved Drug Delivery System: Methods and Applications
Cristiana Ulpiano, Cláudia L. da Silva, Gabriel A. Monteiro Biomedicines.2023; 11(4): 1231. CrossRef - Mmu-miR-25-3p promotes macrophage autophagy by targeting DUSP10 to reduce mycobacteria survival
Wenqi Yuan, Xuehua Zhan, Wei Liu, Rong Ma, Yueyong Zhou, Guangxian Xu, Zhaohui Ge Frontiers in Cellular and Infection Microbiology.2023;[Epub] CrossRef - Exosomes in brain diseases: Pathogenesis and therapeutic targets
Qingying Si, Linlin Wu, Deshui Pang, Pei Jiang MedComm.2023;[Epub] CrossRef - Repressor Element-1 Binding Transcription Factor (REST) as a Possible Epigenetic Regulator of Neurodegeneration and MicroRNA-Based Therapeutic Strategies
Ajmal Nassar, Sairaj Satarker, Prasada Chowdari Gurram, Dinesh Upadhya, SM Fayaz, Madhavan Nampoothiri Molecular Neurobiology.2023; 60(10): 5557. CrossRef - Standardization Approaches for Extracellular Vesicle Loading with Oligonucleotides and Biologics
Josepha Roerig, Michaela Schulz‐Siegmund Small.2023;[Epub] CrossRef - Small extracellular vesicles: a novel drug delivery system for neurodegenerative disorders
Renjie Pan, Dongdong Chen, Lanlan Hou, Rong Hu, Zhigang Jiao Frontiers in Aging Neuroscience.2023;[Epub] CrossRef - Mesenchymal Stem Cell-Derived Extracellular Vesicles: An Emerging Diagnostic and Therapeutic Biomolecules for Neurodegenerative Disabilities
Mahmoud Kandeel, Mohamed A. Morsy, Khalid M. Alkhodair, Sameer Alhojaily Biomolecules.2023; 13(8): 1250. CrossRef - Research progress on the role of extracellular vesicles in neurodegenerative diseases
Zhengzhe Li, Xiaoling Wang, Xiaoxing Wang, Xiaomei Yi, Yin Kwan Wong, Jiyang Wu, Fangfang Xie, Die Hu, Qi Wang, Jigang Wang, Tianyu Zhong Translational Neurodegeneration.2023;[Epub] CrossRef - Exosomes as cell-derivative carriers in the diagnosis and treatment of central nervous system diseases
Gayatri Gopal Shetgaonkar, Shirleen Miriam Marques, Cleona E. M. DCruz, R. J. A. Vibhavari, Lalit Kumar, Rupesh Kalidas Shirodkar Drug Delivery and Translational Research.2022; 12(5): 1047. CrossRef - Emerging prospects of extracellular vesicles for brain disease theranostics
Ruoning Wang, Xiaohong Wang, Yuting Zhang, Huacong Zhao, Jiwei Cui, Junsong Li, Liuqing Di Journal of Controlled Release.2022; 341: 844. CrossRef - Stem Cell Transplantation Therapy and Neurological Disorders: Current Status and Future Perspectives
Md. Rahman, Md. Islam, Mohammad Islam, Md. Harun-Or-Rashid, Mahfuzul Islam, Sabirin Abdullah, Mohammad Uddin, Sumit Das, Md. Rahaman, Muniruddin Ahmed, Fahad Alhumaydhi, Talha Emran, Amany Mohamed, Mohammad Faruque, Mayeen Khandaker, Gomaa Mostafa-Hedeab Biology.2022; 11(1): 147. CrossRef - Non-viral vectors for RNA delivery
Yi Yan, Xiao-Yu Liu, An Lu, Xiang-Yu Wang, Lin-Xia Jiang, Jian-Cheng Wang Journal of Controlled Release.2022; 342: 241. CrossRef - MicroRNA-22: a Novel and Potent Biological Therapeutics in Neurological Disorders
Seyed Hamidreza Rastegar-moghaddam, Alireza Ebrahimzadeh-Bideskan, Sara Shahba, Amir Mohammad Malvandi, Abbas Mohammadipour Molecular Neurobiology.2022; 59(5): 2694. CrossRef - Functional Extracellular Vesicles for Regenerative Medicine
Han Young Kim, Seunglee Kwon, Wooram Um, Sol Shin, Chan Ho Kim, Jae Hyung Park, Byung‐Soo Kim Small.2022;[Epub] CrossRef - Emerging role of exosomes in the pathology of chronic obstructive pulmonary diseases; destructive and therapeutic properties
Hadi Rajabi, Nur Konyalilar, Sinem Erkan, Deniz Mortazavi, Seval Kubra Korkunc, Ozgecan Kayalar, Hasan Bayram, Reza Rahbarghazi Stem Cell Research & Therapy.2022;[Epub] CrossRef - MicroRNA Alteration, Application as Biomarkers, and Therapeutic Approaches in Neurodegenerative Diseases
T. P. Nhung Nguyen, Mandeep Kumar, Ernesto Fedele, Giambattista Bonanno, Tiziana Bonifacino International Journal of Molecular Sciences.2022; 23(9): 4718. CrossRef - Protective Signature of IFNγ-Stimulated Microglia Relies on miR-124-3p Regulation From the Secretome Released by Mutant APP Swedish Neuronal Cells
Gonçalo Garcia, Adelaide Fernandes, Frank Stein, Dora Brites Frontiers in Pharmacology.2022;[Epub] CrossRef - Therapeutic Potential of Exosomes Derived from Diabetic Adipose Stem Cells in Cutaneous Wound Healing of db/db Mice
Hsiang-Hao Hsu, Aline Yen Ling Wang, Charles Yuen Yung Loh, Ashwin Alke Pai, Huang-Kai Kao Pharmaceutics.2022; 14(6): 1206. CrossRef - Recent progresses in exosome-based systems for targeted drug delivery to the brain
Santosh Bashyal, Chhitij Thapa, Sangkil Lee Journal of Controlled Release.2022; 348: 723. CrossRef - MicroRNA-124 attenuates PTSD-like behaviors and reduces the level of inflammatory cytokines by downregulating the expression of TRAF6 in the hippocampus of rats following single-prolonged stress
Yao Chen, Qi An, Shu-Ting Yang, Yu-Lu Chen, Lei Tong, Li-Li Ji Experimental Neurology.2022; 356: 114154. CrossRef - Exosomes─Nature’s Lipid Nanoparticles, a Rising Star in Drug Delivery and Diagnostics
Rumiana Tenchov, Janet M. Sasso, Xinmei Wang, Wen-Shing Liaw, Chun-An Chen, Qiongqiong Angela Zhou ACS Nano.2022; 16(11): 17802. CrossRef - The emerging role of long non-coding RNAs, microRNAs, and an accelerated epigenetic age in Huntington’s disease
Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Mohammad Taheri, Kaveh Ebrahimzadeh, Rezvan Noroozi Frontiers in Aging Neuroscience.2022;[Epub] CrossRef - Intracellular and intercellular transport of RNA organelles in CXG repeat disorders: The strength of weak ties
Deepti Kailash Nabariya, Annika Heinz, Sabrina Derksen, Sybille Krauß Frontiers in Molecular Biosciences.2022;[Epub] CrossRef - Extracellular vesicles in neurodegenerative diseases: Insights and new perspectives
Qian Yuan, Xiao-dong Li, Si-miao Zhang, Hong-wei Wang, Yun-liang Wang Genes & Diseases.2021; 8(2): 124. CrossRef - Therapeutic antisense oligonucleotides for movement disorders
Epaminondas Doxakis Medicinal Research Reviews.2021; 41(5): 2656. CrossRef - An update on the role of miR-124 in the pathogenesis of human disorders
Soudeh Ghafouri-Fard, Hamed Shoorei, Zahra Bahroudi, Atefe Abak, Jamal Majidpoor, Mohammad Taheri Biomedicine & Pharmacotherapy.2021; 135: 111198. CrossRef - Ancient Evolutionary Origin and Properties of Universally Produced Natural Exosomes Contribute to Their Therapeutic Superiority Compared to Artificial Nanoparticles
Phillip W. Askenase International Journal of Molecular Sciences.2021; 22(3): 1429. CrossRef - Intriguing Biomedical Applications of Synthetic and Natural Cell-Derived Vesicles: A Comparative Overview
Brateen Datta, Debashish Paul, Uttam Pal, Tatini Rakshit ACS Applied Bio Materials.2021; 4(4): 2863. CrossRef - Nucleic acid delivery with extracellular vesicles
Michaela Schulz-Siegmund, Achim Aigner Advanced Drug Delivery Reviews.2021; 173: 89. CrossRef - Emerging Roles of Exosomes in Huntington’s Disease
Hanadi Ananbeh, Petr Vodicka, Helena Kupcova Skalnikova International Journal of Molecular Sciences.2021; 22(8): 4085. CrossRef - Stem Cell-Derived Exosomes: a New Strategy of Neurodegenerative Disease Treatment
Nashmin Fayazi, Mohsen Sheykhhasan, Sara Soleimani Asl, Rezvan Najafi Molecular Neurobiology.2021; 58(7): 3494. CrossRef - Altered microRNA expression in animal models of Huntington’s disease and potential therapeutic strategies
Bridget Martinez, PhilipV Peplow Neural Regeneration Research.2021; 16(11): 2159. CrossRef - Roles of glia-derived extracellular vesicles in central nervous system diseases: an update
Hao Sun, Xiaojuan Su, Shiping Li, Dezhi Mu, Yi Qu Reviews in the Neurosciences.2021; 32(8): 833. CrossRef - Oligonucleotides as therapeutic tools for brain disorders: Focus on major depressive disorder and Parkinson's disease
Analia Bortolozzi, Sharon Manashirov, Alon Chen, Francesc Artigas Pharmacology & Therapeutics.2021; 227: 107873. CrossRef - Perspective insights and application of exosomes as a novel tool against neurodegenerative disorders: An expository appraisal
Amey Kadbhane, Monica Patel, Saurabh Srivastava, Pankaj Kumar Singh, Jitender Madan, Shashi Bala Singh, Dharmendra Kumar Khatri Journal of Drug Delivery Science and Technology.2021; 63: 102526. CrossRef - Harnessing the therapeutic potential of extracellular vesicles for cancer treatment
Ying Zhang, Yu Xiao, Gaoge Sun, Xue Jin, Lerui Guo, Tian Li, Hang Yin Seminars in Cancer Biology.2021; 74: 92. CrossRef - Neural Stem Cell-Derived Exosomes Regulate Neural Stem Cell Differentiation Through miR-9-Hes1 Axis
Ping Yuan, Lu Ding, Huili Chen, Yi Wang, Chunhong Li, Shu Zhao, Xiaoyu Yang, Yizhao Ma, Jie Zhu, Xinrui Qi, Yanyan Zhang, Xiaohuan Xia, Jialin C. Zheng Frontiers in Cell and Developmental Biology.2021;[Epub] CrossRef - Diagnostic and Therapeutic Potential of Exosomal MicroRNAs for Neurodegenerative Diseases
Miao He, Hai-nan Zhang, Zhen-chu Tang, Shu-guang Gao, Laura Baroncelli Neural Plasticity.2021; 2021: 1. CrossRef - Profiling of Extracellular Small RNAs Highlights a Strong Bias towards Non-Vesicular Secretion
Helena Sork, Mariana Conceicao, Giulia Corso, Joel Nordin, Yi Xin Fiona Lee, Kaarel Krjutskov, Jakub Orzechowski Westholm, Pieter Vader, Marie Pauwels, Roosmarijn E. Vandenbroucke, Matthew JA Wood, Samir EL Andaloussi, Imre Mäger Cells.2021; 10(6): 1543. CrossRef - Neuroinflammation: The next target of exosomal microRNAs derived from mesenchymal stem cells in the context of neurological disorders
Mehrdad Hajinejad, Sajad Sahab‐Negah Journal of Cellular Physiology.2021; 236(12): 8070. CrossRef - Exosomal microRNAs from mesenchymal stem/stromal cells: Biology and applications in neuroprotection
Aida Nasirishargh, Priyadarsini Kumar, Lalithasri Ramasubramanian, Kaitlin Clark, Dake Hao, Sabrina V Lazar, Aijun Wang World Journal of Stem Cells.2021; 13(7): 776. CrossRef - Central Nervous System Cell‐Derived Exosomes in Neurodegenerative Diseases
Yang Tian, Chen Fu, Yifan Wu, Yao Lu, Xuemei Liu, Yunling Zhang, Yanfang Xian Oxidative Medicine and Cellular Longevity.2021;[Epub] CrossRef - The regulatory roles of microRNAs toward pathogenesis and treatments in Huntington's disease
Chih-Wei Tung, Pin-Yu Huang, Siew Chin Chan, Pei-Hsun Cheng, Shang-Hsun Yang Journal of Biomedical Science.2021;[Epub] CrossRef - Dosing extracellular vesicles
Dhanu Gupta, Antje Maria Zickler, Samir El Andaloussi Advanced Drug Delivery Reviews.2021; 178: 113961. CrossRef - Therapeutic Potential of Nucleic Acids when Combined with Extracellular Vesicles
Brian Jurgielewicz, Steven Stice, Yao Yao Aging and disease.2021; 12(6): 1476. CrossRef - Effects of exosomal miRNAs in the diagnosis and treatment of Alzheimer’s disease
Guo-hong Cui, Jing Zhu, Ya-chao Wang, Jing Wu, Jian-ren Liu, Hai-dong Guo Mechanisms of Ageing and Development.2021; 200: 111593. CrossRef - MicroRNA-124: A Key Player in Microglia-Mediated Inflammation in Neurological Diseases
Jiuhan Zhao, Zhenwei He, Jialu Wang Frontiers in Cellular Neuroscience.2021;[Epub] CrossRef - DNAJB6b-enriched small extracellular vesicles decrease polyglutamine aggregation in in vitro and in vivo models of Huntington disease
Bhagyashree S. Joshi, Sameh A. Youssef, Reinier Bron, Alain de Bruin, Harm H. Kampinga, Inge S. Zuhorn iScience.2021; 24(11): 103282. CrossRef - Diagnostic and Therapeutic Potential of Exosomes in Neurodegenerative Diseases
Panyue Gao, Xinrong Li, Xinzhe Du, Sha Liu, Yong Xu Frontiers in Aging Neuroscience.2021;[Epub] CrossRef - MiR-124 and the Underlying Therapeutic Promise of Neurodegenerative Disorders
Dong Han, Xiaoyu Dong, Dongming Zheng, Jianfei Nao Frontiers in Pharmacology.2020;[Epub] CrossRef - Circulating Exosomal miRNA as Diagnostic Biomarkers of Neurodegenerative Diseases
Lin Wang, Lijuan Zhang Frontiers in Molecular Neuroscience.2020;[Epub] CrossRef - Current Status of microRNA-Based Therapeutic Approaches in Neurodegenerative Disorders
Sujay Paul, Luis Alberto Bravo Vázquez, Samantha Pérez Uribe, Paula Roxana Reyes-Pérez, Ashutosh Sharma Cells.2020; 9(7): 1698. CrossRef - Progress in the molecular pathogenesis and nucleic acid therapeutics for Parkinson's disease in the precision medicine era
Dunhui Li, Frank L. Mastaglia, Sue Fletcher, Steve D. Wilton Medicinal Research Reviews.2020; 40(6): 2650. CrossRef - MicroRNAs Dysregulation and Mitochondrial Dysfunction in Neurodegenerative Diseases
Mariano Catanesi, Michele d’Angelo, Maria Grazia Tupone, Elisabetta Benedetti, Antonio Giordano, Vanessa Castelli, Annamaria Cimini International Journal of Molecular Sciences.2020; 21(17): 5986. CrossRef - Exosome engineering: Current progress in cargo loading and targeted delivery
Shengyang Fu, Yi Wang, Xiaohuan Xia, Jialin C. Zheng NanoImpact.2020; 20: 100261. CrossRef - Strategies and materials of "SMART" non-viral vectors: Overcoming the barriers for brain gene therapy
Yan Li, Linying Liu, Weihong Ji, Huang Peng, Ruichen Zhao, Xin Zhang Nano Today.2020; 35: 101006. CrossRef - Therapeutic miRNA-Enriched Extracellular Vesicles: Current Approaches and Future Prospects
Javaria Munir, Jeong Kyo Yoon, Seongho Ryu Cells.2020; 9(10): 2271. CrossRef - The Role of Exosomal microRNAs and Oxidative Stress in Neurodegenerative Diseases
Xiaoyu Wang, Yunxiang Zhou, Qiannan Gao, Dongnan Ping, Yali Wang, Wei Wu, Xu Lin, Yuanjian Fang, Jianmin Zhang, Anwen Shao, Yanfang Xian Oxidative Medicine and Cellular Longevity.2020; 2020: 1. CrossRef - Nanocarriers as a powerful vehicle to overcome blood-brain barrier in treating neurodegenerative diseases: Focus on recent advances
Xiaoqian Niu, Jiejian Chen, Jianqing Gao Asian Journal of Pharmaceutical Sciences.2019; 14(5): 480. CrossRef - Blood exosomes as a tool for monitoring treatment efficacy and progression of neurodegenerative diseases
Hanin Abdel-Haq Neural Regeneration Research.2019; 14(1): 72. CrossRef - MiR-124 Enriched Exosomes Promoted the M2 Polarization of Microglia and Enhanced Hippocampus Neurogenesis After Traumatic Brain Injury by Inhibiting TLR4 Pathway
Yongxiang Yang, Yuqin Ye, Chuiguang Kong, Xinhong Su, Xin Zhang, Wei Bai, Xiaosheng He Neurochemical Research.2019; 44(4): 811. CrossRef - Resveratrol (3, 5, 4′-Trihydroxy-trans-Stilbene) Attenuates a Mouse Model of Multiple Sclerosis by Altering the miR-124/Sphingosine Kinase 1 Axis in Encephalitogenic T Cells in the Brain
K. Alexa Orr Gandy, Jiajia Zhang, Prakash Nagarkatti, Mitzi Nagarkatti Journal of Neuroimmune Pharmacology.2019; 14(3): 462. CrossRef - Advances in therapeutic applications of extracellular vesicles
Oscar P. B. Wiklander, Meadhbh Á. Brennan, Jan Lötvall, Xandra O. Breakefield, Samir EL Andaloussi Science Translational Medicine.2019;[Epub] CrossRef - Exosome-mediated therapeutic delivery: A new horizon for human neurodegenerative disorders’ treatment (with a focus on siRNA delivery improvement)
Nayer Seyfizadeh, Narges Seyfizadeh, Sajad Borzouisileh, Farideh Elahimanesh, Vahid Hosseini, Mohammad Nouri Process Biochemistry.2019; 85: 164. CrossRef - Exosomes released from neural progenitor cells and induced neural progenitor cells regulate neurogenesis through miR-21a
Yizhao Ma, Chunhong Li, Yunlong Huang, Yi Wang, Xiaohuan Xia, Jialin C. Zheng Cell Communication and Signaling.2019;[Epub] CrossRef - Exosomal miRNAs in central nervous system diseases: biomarkers, pathological mediators, protective factors and therapeutic agents
Xiaohuan Xia, Yi Wang, Yunlong Huang, Han Zhang, Hongfang Lu, Jialin C. Zheng Progress in Neurobiology.2019; 183: 101694. CrossRef - Role of Exosomes in Central Nervous System Diseases
Wanying Liu, Xiaodan Bai, Ao Zhang, Juanjuan Huang, Shixin Xu, Junping Zhang Frontiers in Molecular Neuroscience.2019;[Epub] CrossRef - miR-124 and Parkinson’s disease: A biomarker with therapeutic potential
Efthalia Angelopoulou, Yam Nath Paudel, Christina Piperi Pharmacological Research.2019; 150: 104515. CrossRef - The Potential Role of MicroRNA-124 in Cerebral Ischemia Injury
Xiaolu Liu, Zhitao Feng, Lipeng Du, Yaguang Huang, Jinwen Ge, Yihui Deng, Zhigang Mei International Journal of Molecular Sciences.2019; 21(1): 120. CrossRef - Epigenetic regulation of astrocyte function in neuroinflammation and neurodegeneration
Matthew Neal, Jason R. Richardson Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2018; 1864(2): 432. CrossRef - Potential of Extracellular Vesicles in Neurodegenerative Diseases: Diagnostic and Therapeutic Indications
Mehrnaz Izadpanah, Arshia Seddigh, Somayeh Ebrahimi Barough, Seyed Abolhassan Shahzadeh Fazeli, Jafar Ai Journal of Molecular Neuroscience.2018; 66(2): 172. CrossRef - Regenerative Approaches in Huntington’s Disease: From Mechanistic Insights to Therapeutic Protocols
Jenny Sassone, Elsa Papadimitriou, Dimitra Thomaidou Frontiers in Neuroscience.2018;[Epub] CrossRef - Exosome-based small RNA delivery: progress and prospects
Mei Lu, Haonan Xing, Zhe Xun, Tianzhi Yang, Pingtian Ding, Cuifang Cai, Dongkai Wang, Xiaoyun Zhao Asian Journal of Pharmaceutical Sciences.2017;[Epub] CrossRef - Extracellular Vesicles in Brain Tumors and Neurodegenerative Diseases
Federica Ciregia, Andrea Urbani, Giuseppe Palmisano Frontiers in Molecular Neuroscience.2017;[Epub] CrossRef - The miR-124 family of microRNAs is crucial for regeneration of the brain and visual system in the planarian Schmidtea mediterranea
Vidyanand Sasidharan, Srujan Marepally, Sarah A. Elliott, Srishti Baid, Vairavan Lakshmanan, Nishtha Nayyar, Dhiru Bansal, Alejandro Sánchez Alvarado, Praveen Kumar Vemula, Dasaradhi Palakodeti Development.2017; 144(18): 3211. CrossRef - Mutant Huntingtin Inhibits αB-Crystallin Expression and Impairs Exosome Secretion from Astrocytes
Yan Hong, Ting Zhao, Xiao-Jiang Li, Shihua Li The Journal of Neuroscience.2017; 37(39): 9550. CrossRef
|