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Myung Chong Lee 1 Article
Spinal Myoclonus Responding to Continuous Intrathecal Morphine Pump
Jung-Eun Ahn, Dallah Yoo, Ki-Young Jung, Jong-Min Kim, Beomseok Jeon, Myung Chong Lee
J Mov Disord. 2017;10(3):158-160.   Published online September 12, 2017
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AbstractAbstract PDF
Spinal myoclonus is a sudden, brief, and involuntary movement of segmental or propriospinal muscle groups. Spinal myoclonus has occasionally been reported in patients undergoing opioid therapy, but the pathophysiology of opioid-induced myoclonus has not been elucidated yet. Here, we present two patients with spinal segmental myoclonus secondary to ischemic and radiation myelopathy. Conventional medications did not help treat persistent myoclonus in both legs. Continuous intrathecal morphine infusion was implanted for pain control in one patient, which relieved spinal myoclonus entirely. This experience led to the application of this method with a second patient, leading to the same gratifying result. Spinal myoclonus reemerged as soon as the morphine pumps were off, which confirmed the therapeutic role of opioids. In contrast to the opioid-induced myoclonus, these cases show a benefit of opioids on spinal myoclonus, which could be explained by synaptic reorganization after pathologic insults in the spinal cord.


Citations to this article as recorded by  
  • Spinal segmental myoclonus following spinal surgery
    Shrikant Pande, Kokcher Ang, May Win Myat, Shermyn Neo, Sivashankar Subramaniam
    British Journal of Neurosurgery.2023; 37(3): 393.     CrossRef
  • Movement Disorders Associated With Radiotherapy and Surgical Procedures
    Bharath Kumar Surisetti, Shweta Prasad, Vikram Venkappayya Holla, Nitish Kamble, Ravi Yadav, Pramod Kumar Pal
    Journal of Movement Disorders.2023; 16(1): 42.     CrossRef
  • Myoclonus: An Electrophysiological Diagnosis
    Shabbir Hussain I. Merchant, Felipe Vialā€Undurraga, Giorgio Leodori, Jay A. van Gerpen, Mark Hallett
    Movement Disorders Clinical Practice.2020; 7(5): 489.     CrossRef

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