- Association Between Gait and Dysautonomia in Patients With De Novo Parkinson’s Disease: Forward Gait Versus Backward Gait
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Seon-Min Lee, Mina Lee, Eun Ji Lee, Rae On Kim, Yongduk Kim, Kyum-Yil Kwon
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J Mov Disord. 2023;16(1):59-67. Published online September 7, 2022
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DOI: https://doi.org/10.14802/jmd.22045
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Abstract
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- Objective
Studies on gait and autonomic dysfunction have been insufficient so far, particularly de novo Parkinson’s disease (PD). The aim of this study was to identify the association between gait dynamics and autonomic dysfunction in patients with de novo PD.
Methods A total 38 patients with de novo PD were retrospectively included in this study. Details of patients’ dysautonomia were assessed using the Scales for Outcomes in Parkinson’s Disease-Autonomic Dysfunction (SCOPA-AUT). For assessment of gait, a computerized gait analysis was performed using the GAITRite system for forward gait and backward gait. High SCOPA-AUT score (PD-HSAS) group and low SCOPA-AUT score (PD-LSAS) group were identified according to their SCOPA-AUT scores.
Results Nineteen (50%) patients with high SCOPA-AUT scores above median value (12.5) were assigned into the PD-HSAS group and others were assigned to the PD-LSAS group. Compared with the PD-LSAS group, the PD-HSAS group exhibited slower gait, shorter stride, decreased cadence, increased double support phase, decreased swing phase, and increased variability in swing time. Total SCOPA-AUT score showed significantly positive correlations with gait variability and instability but a negative correlation with gait hypokinesia. In subdomain analysis, urinary dysautonomia was highly associated with impairment of gait dynamics. All significant results were found to be more remarkable in backward gait than in forward gait.
Conclusion Our findings suggest that alteration in gait dynamics, especially backward gait, is highly associated with autonomic dysfunction in patients with de novo PD.
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Citations
Citations to this article as recorded by
- Association between autonomic dysfunction with motor and non-motor symptoms in patients with Parkinson's disease
Yi Qin, De-Tao Meng, Zhao-Hui Jin, Wen-Jun Du, Bo-Yan Fang Journal of Neural Transmission.2024; 131(4): 323. CrossRef - Determinants of Dual-task Gait Speed in Older Adults with and without
Parkinson’s Disease
André Ivaniski-Mello, Vivian Torres Müller, Lucas de Liz Alves, Marcela Zimmermann Casal, Aline Nogueira Haas, Luca Correale, Ana Carolina Kanitz, Valéria Feijó Martins, Andréa Kruger Gonçalves, Flávia Gomes Martinez, Leonardo Alexandre Peyré-Tartaruga International Journal of Sports Medicine.2023; 44(10): 744. CrossRef
- Risk Factors for Falls in Patients with de novo Parkinson’s Disease: A Focus on Motor and Non-Motor Symptoms
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Kyum-Yil Kwon, Mina Lee, Hyunjin Ju, Kayeong Im
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J Mov Disord. 2020;13(2):142-145. Published online May 29, 2020
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DOI: https://doi.org/10.14802/jmd.20009
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6,197
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184
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9
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Abstract
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- Objective
We aimed to identify risk factors for falls in patients with de novo Parkinson’s disease (PD). Methods Forty-six patients with de novo PD were retrospectively included in the study. We assessed details on the patients’ motor symptoms as well as non-motor symptoms using several representative scales for global cognition, depression, fatigue, and dysautonomia. Fallers and non-fallers were identified according to their history of falls during the preceding year. Results Twenty-two patients (45.8%) with de novo PD had a history of falls. Compared with the non-faller group, the faller group exhibited higher scores for postural instability/gait difficulty (PIGD), anxiety, fatigue, total dysautonomia, gastrointestinal dysfunction, and thermoregulatory dysfunction. Moreover, logistic regression analysis showed that falling was positively correlated with anxiety and gastrointestinal symptoms but negatively associated with the tremor scores. Conclusion Our findings suggest that falling in patients with de novo PD is significantly associated with PIGD/non-tremor symptoms, anxiety, and gastrointestinal dysfunction.
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Citations
Citations to this article as recorded by
- Vestibular dysfunction in Parkinson’s disease: a neglected topic
Meilin Gui, Lingling Lv, Lixia Qin, Chunyu Wang Frontiers in Neurology.2024;[Epub] CrossRef - PROGNOSTIC VALUES OF CIRCADIAN RHYTHM AND SLEEP PARAMETERS IN ASSESSMENT OF STATE ANXIETY IN PARKINSON’S DISEASE WITH REGARD TO MOTOR SUBTYPE
Anastasiia Shkodina, Kateryna Tarianyk, Mykhailo Delva Eastern Ukrainian Medical Journal.2024; 12(3): 286. CrossRef - Association Between Gait and Dysautonomia in Patients With De Novo Parkinson’s Disease: Forward Gait Versus Backward Gait
Seon-Min Lee, Mina Lee, Eun Ji Lee, Rae On Kim, Yongduk Kim, Kyum-Yil Kwon Journal of Movement Disorders.2023; 16(1): 59. CrossRef - Fluctuations in Upper and Lower Body Movement during Walking in Normal Pressure Hydrocephalus and Parkinson’s Disease Assessed by Motion Capture with a Smartphone Application, TDPT-GT
Chifumi Iseki, Shou Suzuki, Tadanori Fukami, Shigeki Yamada, Tatsuya Hayasaka, Toshiyuki Kondo, Masayuki Hoshi, Shigeo Ueda, Yoshiyuki Kobayashi, Masatsune Ishikawa, Shigenori Kanno, Kyoko Suzuki, Yukihiko Aoyagi, Yasuyuki Ohta Sensors.2023; 23(22): 9263. CrossRef - Associations of cognitive dysfunction with motor and non-motor symptoms in patients with de novo Parkinson’s disease
Kyum-Yil Kwon, Suyeon Park, Rae On Kim, Eun Ji Lee, Mina Lee Scientific Reports.2022;[Epub] CrossRef - Initial Vestibular Function May Be Associated with Future Postural Instability in Parkinson’s Disease
Jeong Ho Park, Min Seung Kim, Suk Yun Kang Journal of Clinical Medicine.2022; 11(19): 5608. CrossRef - Association of fall risk factors and non-motor symptoms in patients with early Parkinson’s disease
Kyum-Yil Kwon, Suyeon Park, Eun Ji Lee, Mina Lee, Hyunjin Ju Scientific Reports.2021;[Epub] CrossRef - Understanding the Influence of Pain and Fatigue On Physical performance, Fear of Falling and Falls in People With Parkinson’s Disease: A Pilot Study
Hanan Khalil, Nesreen Alissa, Alham Al-Sharman, Islam E’leimat, Majdi Al Qawasmeh, Khalid El-Salem Neurodegenerative Disease Management.2021; 11(2): 113. CrossRef - Assessment of Risk Factors for Falls among Patients with Parkinson’s Disease
Jacek Wilczyński, Magdalena Ścipniak, Kacper Ścipniak, Kamil Margiel, Igor Wilczyński, Rafał Zieliński, Piotr Sobolewski, Stefano Brunelli BioMed Research International.2021; 2021: 1. CrossRef
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